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BOSTON -- The science of cancer prevention has advanced to the point where researchers now say they can detect "cancer genes" in the breath of smokers, and can test the presence of two proteins in men they say will predict development of prostate cancer a decade in advance. All of these novel findings need much more examination, of course, but scientists at the American Association for Cancer Research's Frontiers in Cancer Prevention Research meeting, say these examples illustrate how it is becoming increasingly possible to use genes and their protein products to help predict and diagnose cancer, as well as choose therapy that offers the most potential for a good result. These researchers will also discuss a test that can pick out patients who have pancreatic cancer - an advance that offers hope the disease can be treated at earlier stages than it is now - and how several unique genes can predict which prostate cancer or lung cancer patients will develop aggressive tumors that need additional treatment. Cancer is a disease of genes, they say, so genes can be employed as a crystal ball to thwart the disease.
Lung carcinogenesis tracked by DNA methylation mapping in exhaled breath
For the first time, researchers have demonstrated that it is possible to detect DNA methylation in the breath of smokers and lung cancer patients, suggesting that, in theory, it may be possible to use this technique to identify people who have undiagnosed lung cancer or are at high risk of developing the disease.
Investigators at the Wadsworth Center, the public health laboratory of the New York State Department of Health, have been able to develop an assay that simultaneously detects the presence of methylation in six tumor suppressor genes - a process by which a gene is chemically silenced. The assay examines the promoter region of a gene, where certain cytosine nucleotide bases may be methylated, preventing the gene from being expressed.
The seven participants tested so far breathe for ten minutes into a commercially available handheld device, which cools the air, forming a condensed vapor, to which the methylation assay is applied. Investigators found it could detect the presence of the methylated form in all six tumor suppressor genes. For RASSF1A, the test was negative in non-smokers, and positive in both current and ex-smokers. For DAPK, methylation was more variable, given smoking status. The four other tested genes (p16, MGMT, PAX5B,CDH1) known to be methylated in various stages of lung cancer development, were minimally or not methylated, in this pilot study of predominantly cancer-free smokers.
"Dr. Weiguo Han and I have shown that this approach is technically feasible, and if further research demonstrates the assay can measure DNA in such a way that it diagnoses or predicts lung cancer, this could be important for non-invasive lung cancer testing," said the study's lead author, Simon D. Spivack, M.D., M.P.H., a research physician at the Wadsworth Center, and a specialist in lung diseases. "But we are a long way from that point." Han, a post-doctoral fellow in Spivacks' laboratory and the study's first author, will be presenting the findings.
Spivack said his study was only the third to date that proved DNA could be tested in condensed breath - German researchers reported the first such result in 2003, followed by an Italian group in 2005 - and the first to find methylation-silenced tumor suppressor genes in the breath of patients at risk or harboring lung cancer.
"The concept of testing exhaled breath is not new - that's what breathalyzers do when they measure small volatile molecules such as alcohol, as well as inflammation molecules that are currently being assayed to test the activity of asthma and other lung diseases," said Spivack. "But what is rather remarkable here is that DNA can be tested in the air that comes from the lungs and airways, and that it might be possible to use this in diagnosis of lung cancer in particular, and gene-dysregulation disorders of the lung, in general."
The DNA is believed to be released when cells turn over, or are damaged, in the lungs and airways, he said. "Although it is not possible to say at this point the precise anatomic origin of the airway-derived DNA being tested, it may be that different patterns of gene methylation will themselves actually map the origin of this DNA to particular regions of the airway," Spivack said.
"Our goal is early detection of lung cancer and risk stratification," he said. "If all we can do is confirm that a smoker is smoking, or that a lung cancer patient has cancer, then this test will be meaningless. But we now know it is technically feasible to measure DNA methylation in breath."
Multiplexed serum markers screening for detection of pancreatic cancer
A panel of 10 blood biomarkers performed almost perfectly in picking out people who had pancreatic cancer from those who didn't, according to researchers at the University of Pittsburgh. The advance raises hopes that a test can be developed to screen for the aggressive cancer in time to treat it, they say.
"Early detection of pancreatic cancer is crucial to survival, but there has been no way to diagnose it early before symptoms occur," said the lead investigator, Anna E. Lokshin, Ph.D., an associate professor of medicine and pathology at the University of Pittsburgh School of Medicine. "This assay represents a new way to screen for disease that appears to be applicable to pancreatic cancer, and potentially, to other cancer types."
The assay contains the largest panel of blood-based biomarkers to be examined simultaneously in pancreatic cancer. It consists of proteins known to be secreted by pancreatic tumors as well as proteins that represent the body's response to that tumor growth, Lokshin said.
"Tumors are located in the context of certain tissues, and those tissues react in their own individual ways to the cancer," she said. "For example, tissue-specific proteins try to fight the cancer, and each tumor type grows blood vessels in tissue uniquely, so we believe the body responds differently to each kind of cancer."
The researchers initially evaluated a panel of 44 protein biomarkers, including cytokines, chemokines, adhesion molecules and hormones, and used blood from 100 pancreatic cancer patients and a control group of 400 healthy people to find those associated with the cancer. They used a microbead array, which can sample up to 100 different proteins simultaneously, and found 10 biomarkers that offered the highest diagnostic power, Lokshin said. Two of those biomarkers are CA125, which can detect a number of cancers but which is not very specific, and CA19-9, which has been known to correlate weakly with pancreatic cancer.
They found that this panel of markers correctly identified pancreatic cancers 97 percent of the time, with a sensitivity of 95 percent (meaning it could correctly identify cancerous lesions) and with a 98 percent specificity (the ability to detect truly negative cases).
The researchers are continuing to study, validate, and perfect the assay, and test its ability to identify pancreatic cancer at early, treatable stages. Although pancreatic cancer is relatively rare, survival is poor compared to most other forms of cancer - it is the fourth leading cause of cancer-related deaths in males and the fifth-leading cause of cancer-related deaths in females.
A diagnostic screen for pancreatic cancer would likely first be used in smokers, because use of tobacco is a known risk factor for developing pancreatic cancer, Lokshin said.
The researchers also are developing similar assays for ovarian, breast, lung, endometrial, head and neck, and esophageal cancers. "So far, every panel is different for each cancer to the point where we can say with greater than 97 percent certainty which cancer it is," she said.
"Surprisingly, although in theory body response could be similar for several cancers, in practice it is very different."
TMPRSS2-ERG fusion prostate cancer: an early molecular event associated with invasion
The presence of a gene fusion in prostate tumors is significantly associated with aggressive cancer, metastatic spread, and an increased probability of death, a team of researchers is reporting.
They say that the new gene, formed by the fusion of TMPRSS2 and ERG, may serve as a biomarker to separate patients who might benefit from radical prostate cancer therapy from those who potentially need little, if any, treatment.
"We believe this gene has the potential to be used as a diagnostic and prognostic test, which could offer thousands of patients peace of mind and spare them from unnecessary surgery and therapy," said the study's lead author, Sven Perner, M.D.,, a postdoctoral fellow in the Department of Pathology at Harvard University's Brigham and Women's Hospital in Boston. He worked with researchers from the Universities of California and Michigan, Johns Hopkins University and McGill University in Montreal.
Perner and his colleagues reported the discovery of the fused gene last year and they now say that TMPRSS2-ERG occurs in about 50 percent of prostate cancers - making it the most common genetic aberration in human cancer, and the first one found in a common solid cancer. Fused genes and chromosomal rearrangements have been found in several blood cancers, such as chronic myelogenous leukemia (CML) and in soft tissue tumors, such as Ewing's sarcoma, but these diseases are rare compared to prostate cancer, which is one of the leading cancers among American men.
In this study, the researchers sought to learn whether TMPRSS2-ERG is associated with a particular prostate cancer stage, and how it might be contributing to development of the cancer. They gathered 406 prostate tissue samples, representing a range of benign, precursor, and malignant prostate lesions, and used a FISH analysis to look for TMPRSS2-ERG. They didn't find any evidence of the fused gene in non-cancerous samples, but found it was present in 48.5 percent of localized prostate cancer tumors, 30 percent of hormone-naïve metastases, and in 33 percent of hormone refractory metastasis, as well as in about 20 percent of prostatic intraepithelial neoplasias, a lesion believed to be precursor of invasive prostate cancer.
The investigators also discovered that the gene fusion could occur in two different ways. The genes, TMPRSS2, which is regulated by the male sex-hormone androgen, and ERG, which is a potential oncogene, are located close to one another on chromosome 21. When fused, TMPRSS2 drives over-expression of the ERG gene. According to Perner, fusion can occur when the piece of DNA separating the genes breaks off and the genes merge (a process described as "fusion through deletion"), or if parts of each gene break off and switch positions ("translocation").
They found that TMPRSS2-ERG fusion through deletion was more common in the tumor samples as compared to TMPRSS2-ERG fusion through translocation. More recent work has found a significant association between TMPRSS2-ERG fusion and death from prostate cancer, although the researchers have not yet been able to determine which fusion form predicted the highest risk of death.
Perner says investigators are hoping to find a small molecule to inhibit the TMPRSS2-ERG fusion protein in the same way that the drug Gleevec has revolutionized care of CML.
Prediagnostic interleukin-6, C-reactive protein and prostate cancer incidence and mortality
Increased levels of two markers of inflammation, interleukin-6 (IL-6) and C-reactive protein (CRP), are significantly associated with prostate cancer incidence and mortality almost a decade prior to diagnosis, say researchers at the Harvard School of Public Health.
They also found that elevated CRP in these men was associated with a two-fold increased risk of developing fatal prostate cancer, compared to men with the lowest levels of the protein.
"The results of this study provide further evidence that inflammation is involved in development and progression of prostate cancer," said the study's lead author, Jennifer Rider Stark, a graduate student in epidemiology.
Stark said that IL-6 and CRP were more strongly associated with prostate cancer risk and death from prostate cancer in normal weight men. Because IL-6 is secreted from adipose (fat) tissue, levels of the cytokine are naturally higher in overweight or obese men. "It is possible that high levels of IL-6 and CRP in men with a healthy body weight may be more indicative of a pro-inflammatory environment in the prostate," she said.
Some studies have already shown that high levels of IL-6 and CRP can be associated with a poor prognosis in prostate cancer patients, but this is one of only a few studies to examine whether these markers can predict risk before symptoms develop and cancer is diagnosed.
The findings come from a prospective study nested within the Physician's Health Study, and included 516 men who later developed prostate cancer and 516 matched controls who did not. The researchers examined blood taken from each participant early in the study - a median of 9.4 years before prostate cancer was diagnosed in the cases. Levels of IL-6 and CRP were compared among men who did and did not go on to develop cancer. Long-term follow-up of the cases also allowed the researchers to assess the effect of these markers on prostate cancer mortality.
They found that high levels of CRP in the blood was associated with a higher incidence of prostate cancer development among all patients and associated with a two-fold increased risk of developing lethal prostate cancer. IL-6 levels were not associated with prostate cancer risk overall. But when they separated out men by body mass index, those who had a healthy weight and high IL-6 in their blood had a 40 percent higher risk of developing prostate cancer.
Researchers suspect that abnormal amounts of IL-6 and CRP are markers of biological processes involved in development of a number of diseases, including cancer. IL-6 is secreted by immune cells in response to infection or trauma, and it, in turn, stimulates synthesis of CRP in the liver, which is believed to play a role in response to infections and cellular damage control. CRP has been found to be a marker of cardiovascular disease, diabetes and colon cancer, but its use as a cardiology screening test has been controversial.
Stark noted that the predictive power of these two markers for determining prostate cancer risk and mortality needs to be confirmed in other prospective studies. She added, "Understanding the role of inflammation in prostate cancer is important because inflammatory pathways could potentially be targeted for prevention and treatment."
Characteristics of long-term lung cancer survivors
In preliminary findings from an ongoing study, researchers at Mayo Clinic have identified four different factors they say predicts long-term survival in patients diagnosed with lung cancer, and one of the strongest is inheritance of a gene variant, GSTM1 positive, which is more efficient than another allele type of the GSTM1 gene at detoxifying carcinogens.
They found that patients with a null type at this gene were four times more likely to die within two years as were matched patients who had the positive variant.
The researchers also found that patients who had surgery, who were active, and whose cancer did not come back or progress were much more likely to survive five years or longer.
"Outcome varies among lung cancer patients, even within groups that have the same stage at the time of diagnosis, and so it is difficult to know how aggressively to treat and provide follow-up care for individual patients," said the study's lead investigator, Ping Yang, M.D., Ph.D., a clinical and genetic epidemiologist at Mayo Clinic.
"In order to enhance both survival and quality of life, we are trying to establish a model that will identify patients who would benefit from additional clinical intervention, and the data we have accumulated to date could be enormously helpful," she said.
To derive these predictive factors, the researchers aim to compare 400 lung-cancer patients treated at Mayo Clinic and who have survived five or more years, with 400 patients who lived less than two years after treatment. The researchers match the groups by age at diagnosis, gender, tumor cell type, cancer stage and the number of primary lung cancers, and they examine blood samples and follow the progress of the patients' disease as well as their quality of life.
In an interim analysis of data on 150 patients in each group, the researchers specifically found that patients who experienced any progression or recurrence of their cancer were almost three times more likely to die within two years, compared to patients of the same cancer stage whose disease did not progress or return.
They also concluded that lung cancer patients who had surgery were three times as likely to have longer survival as matched patients who did not have surgery. "This can be very useful information for patients who are undecided about whether they should risk having surgery," she said.
Patients who reported being "unable to do work or could only do light work" were at a 2.7-5.8 fold higher probability of dying within two years than were patients who were active, the researchers also discovered. "The clinical care of these patients is a long- term process," Yang said. "If, through follow-up and monitoring, we find a patient is physically inactive, we may recommend exercise and rehabilitation as appropriate to keep them stronger."
Knowing the contribution of inheriting a GSTM1 gene form to outcome is also important, she said. "If our model tells us that a patient's cancer has a higher chance of recurring or progressing because of innate genetics in metabolism, we can watch them more closely, and consider treating them aggressively and promoting preventive measures," Yang said.
The GSTM1 gene is just one of many candidate genes the investigators are studying in these patients.
The mission of the American Association for Cancer Research is to prevent and cure cancer. Founded in 1907, AACR is the world's oldest and largest professional organization dedicated to advancing cancer research. The membership includes more than 24,000 basic, translational, and clinical researchers; health care professionals; and cancer survivors and advocates in the United States and more than 70 other countries. AACR marshals the full spectrum of expertise from the cancer community to accelerate progress in the prevention, diagnosis and treatment of cancer through high-quality scientific and educational programs. It funds innovative, meritorious research grants. The AACR Annual Meeting attracts over 17,000 participants who share the latest discoveries and developments in the field. Special Conferences throughout the year present novel data across a wide variety of topics in cancer research, diagnosis and treatment. AACR publishes five major peer-reviewed journals: Cancer Research; Clinical Cancer Research; Molecular Cancer Therapeutics; Molecular Cancer Research; and Cancer Epidemiology, Biomarkers & Prevention. Its most recent publication, CR, is a magazine for cancer survivors, patient advocates, their families, physicians, and scientists. It provides a forum for sharing essential, evidence-based information and perspectives on progress in cancer research, survivorship and advocacy.


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Popova L.A., Golovina L.N., Gintov V.V., Shamanin A.A.
The article presents the results of a comprehensive assessment of potato samples of the breeding of Russian Potato Research Center in the northern territories of the Arkhangelsk region. The aim of the research was to assess the adaptability of new potato samples in the nurseries of the environmental test to create a new highly productive, nematode resistant variety adapted to the conditions of the northern regions of Russia. Comprehensive assessment of hybrids was carried out on the following indicators: duration of phenological phases, yield, disease damage, starch and dry matter content in tubers, adaptability factor. The Holmogorskiy variety from the group early and Elizaveta from the middle-early group have been adopted for the standard. The adaptive potential of samples capable of providing high productivity in the annual changes in weather conditions of the Arkhangelsk region is calculated. According to the results of a visual assessment on resistance to risoctoniosis and viral diseases, all the samples tested showed high and very high resistance. During two years of research in the main harvest, high yields from the early group formed potato samples of 211/9 – 41.1 t per hectare (19.0 t/ha to St), from the group medium-early – a 4568/10 variety sample with a yield of 40.8 tons per hectare (11 t/ha to St). In the course of research, samples with high plasticity and productivity have been identified. The most adaptive to the growing conditions were: from the group early variety sample 211/9 with an adaptability factor of 1.51; of the average group -4568/10 with an adaptability ratio of 1.51 and 3 samples with an adaptability ratio of more than 1 (1509/1, 4602/9 and 4568/6). Field testing of potato samples has led to the selection of species with high biological and economic potential to create a new, highly productive, nematode resistant potato variety. As a result of preliminary testing for resistance of hybrid 4568/10 to cancer pathogen (Dalem pathotype) and golden potato nematode (pathotype RO1) in laboratory conditions (2019) and in field conditions (2020) at the All-Russian potato testing point for resistance to cancer and nematode (RPRC), the presented sample was characterized as resistant. Variety sample 4568/10 is planned to be submitted to the State Variety Testing in 2021.
Key words: potato, varieties, integrated assessment, adaptability, coefficient of adaptability, productivity, maturity groups, yield, resistance to diseases and pests
Popova L.A., Cand. Sci. (Econ.), senior research fellow. E-mail: firstname.lastname@example.org
Golovina L.N., senior research fellow
Gintov V.V., Cand. Sci. (Econ.), leading research fellow
Shamanin A.A., research fellow of the crop production laboratories. E-mail: email@example.com
Primorsky branch of the FSBI of Science of the Federal Research Centre for Integrated Arctic Research named after the academician N.P. Laverov of the Russian Academy of Sciences – Archangel Research Institute of Agriculture (Primorsky branch of FCIARctic – ARIA)
- Simakov E.A., Sklyarova N.P., Yashina I.M. Methodological guidelines for the technology of potato selection process. Moscow. 2006. 71 p. (In Russ.).
- GOST 29267-91. Seed potatoes. Improved the source material. Acceptance and analysis methods [Web resource] URL: http://docs.cntd.ru/document/1200024936. Date of access: 18.01.20 (In Russ.).
- Dospekhov B.A. Method of field experience (with the basics of statistical processing of research results). Moscow. Agropromizdat. 1985. 351 p. (In Russ.).
- Zhivotkov L.A., Morozova Z.A., Sekutaeva L.I. Methods for identifying potential productivity and adaptability of varieties and breeding forms of winter wheat according to the indicator «yield». Selection and seed production. 1994. No2. Pp. 3–6 (In Russ.).
- Torikov V.E., Bogomaz O.A. Adaptive and productive potential of new generation potato varieties. Bulletin of the Bryansk State Agricultural Academy. 2008. No4. Pp. 53–59 (In Russ.).
For citing: Assessment of the adaptability of potato samples in the northern territories of the Arkhangelsk region. L.A. Popova, L.N. Golovina, V.V. Gintov, A.A. Shamanin. Potato and vegetables. 2021. No1. Pp. 34-37. https://doi.org/10.25630/PAV.2021.36.25.004 (In Russ.).

domain: agronomy


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"What You Dont See," a Whale Ocean Moon Print by Deborah Gregg
"What You Don't See" a PRINT by Deborah Gregg
"The best part is that it doesn't matter whether you believe it or not, it's still true. Right now, and always, in places you cannot see and with perfect precision, big things are silently and slowly setting up with a timing all their own, moving closer and closer. Towards you in that rut of yours. Change is in the works. Out of view. Inevitable." ♡ ~Brigitte Dale from the book "Still"
This is an archival photographic PRINT with a luster surface (has a slight sheen but is not high gloss) on Kodak Endura Photographic Professional photo paper. This print measures approx 8"× 8". Copyright is on digital image only, not actual print. Have a great day!

domain: artistic


MOSCOW | Two Olympic gold medalists from Russia denied doping Friday, a day after they were named in a newspaper report detailing state-sponsored cheating at the 2014 Sochi Games.
Bobsled champion Alexander Zubkov and cross-country skier Alexander Legkov were among the athletes accused in a New York Times article of doping by the former head of the Russian national drug-testing laboratory.
“What’s written now in this article is baseless libel,” Zubkov told Russian state TV, adding that he regularly gave doping samples in his career.
“I’m a person who has worked for many years in sport, competed at the Olympics, and I know how much responsibility each athlete bears when they compete at such a high level.”
The article also brought a strong response from the Kremlin. Russian President Vladimir Putin’s spokesman denounced the allegations as “a turncoat’s libel.”
Grigory Rodchenkov, the former head of the Russian lab now living in Los Angeles, told the Times that he was given a spreadsheet of doping athletes by the Sports Ministry ahead of the games. It allegedly bore the names of 15 athletes who later won medals, including Zubkov and Legkov.
The spreadsheet was not published and The Associated Press could not verify it.
Rodchenkov said he then switched out tainted urine samples for clean ones at the doping lab used for the games in Sochi, with help from people he believed to be officers of the Russian security services.
Legkov defended his “honest medals” and said Rodchenkov, who resigned as lab director last year following separate allegations that he covered up doping in track and field, was not a credible source.
“I don’t understand why a person like this should be believed, trusted or anything else,” Legkov said in televised comments.
Zubkov and Legkov are two of Russia’s most prominent winter sports athletes.
Zubkov carried the Russian flag at the opening ceremony for the Sochi Olympics and won gold in the two-man and four-man bobsled events at the age of 39, becoming one of the oldest pilots to win an Olympic event.
Legkov won gold in the men’s 50-kilometer cross-country mass start on the last day of the games and was given his gold medal at the closing ceremony.
Putin spokesman Dmitry Peskov said the Kremlin rejects the accusations that the Russian government oversaw a state-sponsored doping program and subsequent cover-up.
“It just seems like, you know, some kind of a turncoat’s libel,” Peskov said, without mentioning Rodchenkov by name. “I wouldn’t put trust in such unfounded claims.”
The government continues to back Sports Minister Vitaly Mutko, Peskov added.
The World Anti-Doping Agency is set to investigate Rodchenkov’s allegations, and Rodchenkov himself has volunteered to identify which samples he tampered with.
The International Olympic Committee on Thursday said that the “allegations are very detailed and very worrying and we ask the World Anti-Doping Agency to investigate immediately.”
The IOC said, based on the result of the WADA inquiry, that it “will not hesitate to act with its usual policy of zero tolerance for doping and defending the clean athletes.”


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This class incorporates a lot of strength training so that students can continue to build the muscles that will help them master more advanced tricks and tumbling. Each student will receive one on one spotting and instruction as they go across the mat so that they can build confidence in their body’s ability. The Dance Spot’s acrobatic classes fuse dance technique with acrobatic motion, and the tricks taught in this class will be incorporated into studio performances.
Ballet is a beautiful, athletic art form that has been amazing audiences for centuries. It is a disciplined form of dance that strives for perfection while exuding elegance, grace and control. Ballet class is the study of body positions, awareness and alignment. It is a poised style of dance that incorporates the foundational techniques for many other dance forms and is highly suggested as a base to be taken before and during further dance training. This genre of dance is very hard to master and requires much practice but is endlessly beneficial. Dancers will work to improve posture and flexibility. They will concentrate on pointing their feet, strengthening ankles, understanding and increasing turn out, using their plie’, learning to stretch fully through their extensions while keeping their joints supported, etc.
This class gives a student’s dance education concrete meaning by providing specific goals to work towards and milestones to attain with a focus on developing a higher level of understanding of the mechanics and technique of dance. Ballroom class is designed to learn various styles of Ballroom and Latin dances like Chacha, Samba, Jive, Waltz, Tango, etc. Kids will learn techniques and combination of steps that will allow them to dance as individuals, formations or as couples. This class helps develop multiple dance skills, physical skills so as social skills.
Contemporary is a fusion where dancers use every kind of movement, with strong lyrical components but, you will see flares of jazz, ballet, hip hop, salsa, theatrics, mime, modern, pedestrian movement, and more. The fun is in the blending. This class will have a short warm up and then spend the majority of class learning and dancing to new combinations every week. Whether inspired by a song, a feeling, a vision, or just a wild hair, each combination will be unique and allow for much individual artistic freedom.
Hip hop is a very energetic form of dancing. It is unique in that it allows its dancers to perform with freedom of movement, adding in their own personalities. Hip hop dancing is an ideal way to express one’s creativeness. It features self-impressions, and the dances come from the soul. The dancing represents body movements that go with the beat and rhythm of hip hop music. This class focuses on breaking, popping, locking, and free styling in hip hop dances. Dancers will practice various techniques, steps and moves focusing on rhythm, clear and elaborate execution and musical interpretation.
This style of dance is fun and energetic and tends to be a favorite. It is used highly in commercial industries for its entertainment value. Jazz dance has roots in ballet, modern, acrobatics, African rhythm, Caribbean, etc. and is constantly influenced by all genres and, in turn, jazz also influences them. Jazz is normally more up beat, and tends to be more grounded, with strong various movement and dynamic. Our classes will begin with a warm-up exercising muscles and joints to increase strength and mobility. Dancers will work to find The Dance Spot by using their central core and practice coordination techniques and isolations. This will be followed by stretches to increase flexibility and understand turn out. Next will be progressions across the floor, learning transitions, footwork, turns, extensions, jumps, leaps, floor work, etc.
Classic forms of modern dance, such as the Lester Horton Technique, or the teachings of Martha Graham, are a foundational cornerstone of dance in the United States and around the world. Like ballet, these codified systems of instruction and execution have tried and true historical roots and have become staples in the dance vocabulary of today’s professional companies and repertoires. Knowledge and practice in classic modern technique serves not only to strengthen the technique of aspiring professional dancers, but to provide strong foundations that allow artistic freedom when executing unfamiliar, difficult, or particularly nuanced choreography. This class is centered upon developing the various forms of modern techniques and enhancing the range and versatility of our dancers here at TDS.
Muscle memory and repetition are essential to light, ethereal pointe work. This is a class that stresses precision and strength while emphasizing the beauty of a traditional art form. Dancing on pointe should be considered a privilege, the reward for hard work in ballet technique, and participation will be determined by the instructor, with safety and injury prevention top of mind. Throughout the year, students will work on strengthening ankle and feet muscles, increasing their awareness throughout their bodies, and establishing correct alignment for pointe work. Note that dancers in this class are required to be enrolled in 3 ballet classes per week and a ballet class immediately preceding any Pointe class.
Tap classes are designed to develop rhythm, style, and sound. Students will learn a variety of tap styles from Broadway to Rhythm tap. Exercises focus on building flexibility of the knee and ankles, coordination, and speed of movement. The class emphasis is on developing proper tap technique, producing clear tap sounds, and having fun. As students progress through each level curriculum will become increasingly more complex and intricate.
This fun and challenging class focuses on learning “dance tricks”: jumps, turns, floor work and combinations of each. Students will gain strength and placement through conditioning exercises to warm up. These training routines focus on the dancers’ core as well as feet and ankles and will be done in consistent repetition to encourage improved jumping and balancing techniques. Students will then be guided in the proper way to approach their tricks safely, and with correct technique using guided progression tactics. They will practice proper execution, blending tricks with choreography, as well as implementation of acro skills. Dancers can perfect their traditional jumps and turns, be challenged to obtain some new exciting tricks and maybe even create some of their own!
Body Conditioning/Skill Building
Body Conditioning/Skill Building offers a focused approach to strength and conditioning, and is formulated to advance dancers strength in muscle group areas specifically called upon for ballet technique. The students will see a lot of exercises that they may see in ballet, but these exercises are usually done in a more repetitive/intense way to build strength and stamina. There are also exercises and stretches integrated into the class that stems from pilates and yoga practices. This class is considered a ballet credit because of the intentional conditioning to improve turnout, height of develope and jumps, depth of plie, balance, flexibility, etc. The class follows themes that are also presented in ballet classes simultaneously so as to further reinforce technical ideas and practice.

domain: hobby


US 4743032 A
A mechanism is disclosed for presenting a multiplicity of targets to a shooter in a firing range. The mechanism has a plurality of generally planar targets, each attached to a crank arm which, in turn, is attached to an actuating device. The device has an extendable and retractable ram which causes the crank arm to pivot during extension or retraction such that the target is moved between a lowered position, in which it is not visible to the shooter, to a raised position in which the target is visible to the shooter. The mechanism includes a remote control device to actuate one or more of the targets to minimize the presence of any personnel in a downrange position.
1. A modular, multiple target mechanism for presenting a multiplicity of targets to a shooter for firearm target practice comprising:
(a) a plurality of modules, each module comprising:
(i) a support;
(ii) an actuating device having a stationary portion, and an extensible and retractable ram;
(iii) first attaching means for attaching the stationary portion to the support;
(iv) a crank arm;
(v) second attaching means attaching the crank arm to the support such that it pivots about an axis;
(vi) third attaching means attaching the ram to the crank arm such that extension and retraction of the ram causes the crank arm to pivot about its axis; and,
(vii) a generally planar target attached to the crank arm such that the plane of the target extends substantially perpendicular to the pivot axis of the crank arm; and,
(b) means to fasten a plurality of modules together such that the pivot axes of the crank arms are coincident.
2. The modular, multiple target mechanism according to claim 1 further comprising remote control means connected to each activating device.
3. The modular, multiple target mechanism according to claim 1 wherein the actuating device comprises a generally cylindrical stationary portion and an electrically operated ram extendable and retractable with respect to the generally cylindrical stationary portion.
4. The modular, multiple target mechanism according to claim 1 further comprising a projectile location sensor assembly attached to at least one of the plurality of modules.
5. The modular multiple-target mechanism according to claim 1 further comprising a target board located downrange of the plurality of modules, the height and width of the target board being substantially greater than the height and width of each target.
6. The modular, multiple target mechanism according to claim 1 wherein the target of each module has a different aiming mark thereon.
7. The modular, multiple target mechanism according to claim 6 wherein the actuating device comprises a generally cylindrical stationary portion and an electrical motor driven ram extendable and retractable with respect to the generally cylindrical stationary portion.
8. The modular, multiple target mechanism according to claim 7 further comprising remote control means connected to each actuating device.
9. The modular, multiple target mechanism according to claim 8 further comprising a projectile location sensor assembly attached to at least one of the plurality of modules.
10. The modular multiple target device according to claim 9 further comprising a target board located downrange of the plurality of modules, the height and width of the target board being substantially greater than the height and width of each target.
In order to learn or maintain marksmanship capabilities, a shooter must, of course, practice as much as possible. Typically, such practice occurs at a firing range wherein the shooter may fire at a target. The target may be stationary or may be mounted so as to move along a predetermined path.
It is often necessary for the shooter to fire at different sized or shaped targets. This requirement often necessitates a reduction in the shooter's practice firing time, since it is necessary for all shooting to cease while the targets are manually changed. This also requires a relatively large number of personnel located in a downrange position which exposes them to the obvious dangers.
The present invention relates to a multiple target mechanism for presenting a plurality of targets to a shooter. The targets are each attached to a crank arm which is mounted so as to pivot about an axis extending generally perpendicular to the plane of the target. An actuating device comprising a stationary cylinder having an extendable and retractable ram, is interconnected between each crank arm and a support such that expansion or contraction of the ram causes the crank arm to pivot about the pivot axis.
The support may be attached to a stationary housing located behind a mantelet or earthen embankment to protect the mechanism from stray bullets. The targets are deployed in a first or lowered position such that they are below an upper level of the mantelet or embankment and are not visible to the shooter. Remote control means may be activated so as to extend one or more of the rams, causing the crank arm to pivot approximately 90 position above the mantelet or embankment in which it is visible to the shooter. Each of the multiplicity of targets may have different shaped or different sized target silhouettes or aiming marks outlined thereon. Also, two or more targets may have only a portion of the shooting target thereon such that, when both are simultaneously made visible to the shooter, a somewhat larger shooting target is presented.
The multiple target mechanism may be utilized in conjunction with a target board or a witness screen located immediately downrange of the targets so as to provide a target background and an accurate indication of the precise location of the bullet passing through the target. Furthermore, a known projectile locating system may be mounted to the mechanism to indicate the precise path of the bullet.
FIG. 1 is a partial perspective view of a shooting range incorporating a multiple target mechanism according to the invention.
FIG. 2 is a partial, top plan view of the multiple target mechanism according to the invention.
FIG. 3 is a front elevational view of the multiple target mechanism according to the invention showing the targets in their retracted positions.
FIG. 4 is a partial top view, partially broken away, of the multiple target mechanism according to the invention showing the actuating devices.
FIG. 5 is a partial, sectional view taken along line 5--5 in FIG. 4.
FIG. 6 is a partial, sectional view taken along line 6--6 in FIG. 4.
FIG. 7 is a schematic diagram of the control circuit for the multiple target mechanism according to the invention.
The multiple target mechanism according to the invention is indicated at 10 and is shown in FIG. 1 disposed on a mounting structure 12, which may be concrete block or brick, located behind a reinforced concrete retaining wall 14. An embankment 16 of earth or other material is disposed on the uprange side of concrete wall 14 and may have a skid plate 18 located on its upper surface. In FIG. 1, it is to be understood that a shooter (not shown) is located to the left of embankment 16 and the path of the bullet travels in a downrange direction, as indicated by arrow 20. The height of concrete wall 14 and embankment 16 is such that the multiple target mechanism 10 is not visible to the shooter.
A target board or witness screen 22 may be located immediately downrange of the multiple target mechanism 10 so as to provide a background for the target at which the shooter is aiming. The witness screen or target board 22 may also provide a positive indication of the path of the bullet after passing through the target. Witness screen or target board 22 is mounted so as to be visible above the top of the concrete wall 14 and the embankment 16 and is substantially greater in area than targets 24, 26, 28 or 30.
Multiple target mechanism 10 has targets 24, 26, 28 and 30 located thereon and has means for moving each of the targets between a lowered position, shown by targets 26, 28 and 30 in FIG. 1, and a raised position, shown by target 24 in FIG. 1. In the lowered positions, the targets are located below the upper surface of concrete wall 14 and embankment 16 so as to be out of sight of the shooter. When raised to the exposed position, the targets are visible to the shooter as indicated by target 24 in FIG. 1. Although the mechanism is illustrated as having four targets, it is to be understood that the mechanism may incorporate any number of targets without exceeding the scope of this invention.
The mechanism for raising and lowering each of the targets is shown in FIGS. 4, 5 and 6, and comprises crank arms 32 pivotally attached to axle 34 such that they each may pivot about a common axis 36. Axle 34 and pivot axis 36 are common to all of the crank arms 32. Each of the crank arms 32 has a target attached thereto, such as by way of brackets 38. Each of the targets may be formed of plywood either with or without a rubber coating thereon to minimize reflection of shock waves generated by the bullet. Quite obviously, the precise material from which the targets are constructed, per se, forms no part of the invention, and the targets 24, 26, 28 and 30 may be fabricated of any material. Furthermore, the targets may have different sized or shaped silhouettes or aiming marks thereon to provide a variety for the shooter. As illustrated in FIGS. 1 and 3, the target silhouettes are standardized silhouettes used by the U.S. Marine Corps.
Axle 34 extends between end walls 40 and 42 to support all of the crank arms thereon. Intermediate walls 44, 46 and 48 extend generally parallel to end walls 40 and 42 and serve to further support axle 34.
Each of the crank arms 32 is connected to an actuating device 50. Each actuating device 50 comprises a stationary portion 52, which may be generally cylindrical in shape, and an extendable and retractable ram 54. The end of each ram 54 is connected to a crank arm 32 via pivoting connection 56. The actuating device 50 may be electrically actuated and have an electric motor 58 driving a worm gear (not shown) which, in turn, drivingly engages a gear threaded onto ram 54 so as to drive the ram in the direction of arrow 60 in FIG. 6. As the ram 54 extends from the stationary portion 52, it causes crank arm 32 to pivot about axle 34 in a clockwise direction into the position indicated in dashed lines in FIG. 6. This serves to raise the target associated with the crank arm from its lowered position to a raised, visible position. Quite obviously, retraction of ram 54 into stationary portion 52 causes the crank arm to pivot in a counterclockwise direction, as seen in FIG. 6, and return the target to the retracted positions. The stationary portions 52 of the actuating devices 50 are each attached to axle 62 extending along a second common axis 65 and passing through the walls 40, 42, 44, 46 and 48.
Although an electrically actuated ram is described, it is to be understood that pneumatic or hydraulic cylinders having extendable and retractable rams could also be used without exceeding the scope of this invention.
Additional support for the targets in their lowered position may be achieved by cross-brace 64, while a precise location of the targets in their raised positions may be achieved by cross-brace 66 attached to uprights 68. Sidewall 70 is attached to walls 40, 42, 44, 46 and 48. The cross-braces also serve to define the limits of travel of crank arm 32. A housing cover 72 may be placed over the structure to protect the mechanism from exposure to the elements.
A schematic diagram for a typical control circuit for the target mechanism is shown in FIG. 7. Each of the actuating device motors 58 are connected to control box 74 via electrical connections 76 and relays 78. The apparatus is also connected to power supply 80, which may be a 12 V DC power supply as shown. Thus, by actuating one or more of the switches 81 on control box 74, a target may be moved between its lowered and visible positions. The control box 74 is ideally located in a remote location such that it may be actuated by personnel either off to one side or uprange of the firing position so as to minimize the exposure of such personnel to the obvious dangers of being located near the targets themselves. By minimizing the need for any downrange personnel, the device markedly reduces the dangers inherent in shooting range operation.
The multiple target mechanism according to the invention may be mounted either on top of mounting structure 12, as shown in FIG. 1, or may be mounted directly on a concrete base as shown in FIG. 3.
A projectile locating system sensor assembly 82, shown in FIGS. 1, 2 and 3 may be mounted on the mechanism housing 72 as shown. This sensor assembly is utilized in conjunction with a projectile locating system such as that shown and described in U.S. Pat. No. 4,357,531 to Knight. The operation of such a projectile locating system, per se, does not form any part of the present invention.
The target mechanism according to the invention may be formed of a modular construction wherein each module comprises at least a side wall, a crank arm pivotally attached to the side wall and an actuating device. A plurality of such modules may be fastened side by side, such as shown in FIG. 4, to fabricate a target mechanism having any number of targets.
While each target has been described as having a different sized or shaped silhouette, it is possible for each individual target to have a portion of a larger target silhouette. By raising more than one of the targets to the visible position, a somewhat larger target silhouette may be presented to the shooter. It is also possible to incorporate the multiple target mechanism according to this invention on a moveable trolley which moves along a path so as to provide multiple moving targets to the shooter.
The foregoing description has been provided for illustrative purposes only and should not be construed as in any way limiting this invention, the scope of which is defined solely by the appended claims.


text:
Unleashing Dominance in the Digital Battlefield
In the dynamic realm of online gaming สมัครจีคลับ, “Pixel Prowess” emerges as the undisputed champion, dominating the virtual battleground and setting a new standard for gaming excellence.
Elevate Your Gameplay with Pixel Precision
Embark on a gaming journey where precision meets pixel perfection. Pixel Prowess introduces a gaming experience that transcends expectations, with cutting-edge technology ensuring every move is executed with unparalleled accuracy.
The Artistry of Digital Realms
Immerse yourself in the artistry of digital landscapes meticulously crafted by Pixel Prowess. The game’s graphics redefine realism, creating an awe-inspiring visual feast that adds a layer of depth to your online gaming adventures.
Tactical Brilliance in Every Pixel
Pixel Prowess is not just a game; it’s a strategic masterpiece. Engage in tactical brilliance where every decision matters. The intricate details in each pixel create a battlefield where skill and strategy pave the way to victory.
Building Alliances in the Pixel Kingdom
Connect with fellow gamers and build alliances that transcend the virtual realm. Pixel Prowess fosters a community where camaraderie and competition coalesce, adding a social dimension to your conquests in the online gaming arena.
Seize the Pixelated Throne
Emerge victorious in battles, conquer challenges, and ascend the pixelated throne of glory. Pixel Prowess offers a platform where your gaming skills are the key to unlocking unprecedented achievements in the vast digital landscape.
Support the Pixel Revolution
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In conclusion, Pixel Prowess invites you to dominate the online gaming arena with pixelated perfection. From strategic brilliance to breathtaking visuals, this game transcends boundaries, offering an experience where pixels converge, and victories resonate. Join the revolution – Pixel Prowess awaits your mastery!

domain: entertainment


text:
Good to know
|Distance to city centre||1.5 km|
Time of year
Show reviews that mention
The Hepingli Hotel is an ideal choice for travelers who want to take in the sights and sounds of Beijing. Boasting a convenient location, the hotel is just 7km from Beijing Railway Station and 22km from Nanyuan Airport. In addition, Hepinglibeijie Metro Station is just a short walk away. In their spare time, guests can explore the hotel's surroundings. Our guests consider this hotel to have excellent service. This hotel is the usual choice for a large number of business travelers.
based on 2,430 reviews
Things to know
- Friendly atmosphere
- Close to public transport
Policies vary by room type and provider.
FAQs when booking at Beijing Hepingli Hotel
Where is Beijing Hepingli Hotel located?
Beijing Hepingli Hotel is located at No.4 Building, Huagong Yard, Hepingli Xinghua Road, Dongcheng District in Dongcheng, 1.5 km from the centre of Beijing. National Museum of China is the closest landmark to Beijing Hepingli Hotel.
Does Beijing Hepingli Hotel offer free Wi-Fi?
Yes, Beijing Hepingli Hotel offers free Wi-Fi.
Does Beijing Hepingli Hotel offer free parking?
No, Beijing Hepingli Hotel does not offer free parking.
Does Beijing Hepingli Hotel offer free airport shuttle service?
No, Beijing Hepingli Hotel does not offer free airport shuttle service.
How far is Beijing Hepingli Hotel from the airport?
Beijing Hepingli Hotel is 13.5 km from Beijing Nanyuan.
Does Beijing Hepingli Hotel have a pool?
No, Beijing Hepingli Hotel does not have a pool on-site.
Most popular landmarks
- National Museum of China 1.1 km
- Mausoleum of Mao Zedong 1.4 km
- Working People's Cultural Palace 1.6 km
- Tiananmen 1.6 km
- Great Hall of the People 1.7 km
- Beijing Ancient Observatory 1.9 km
|Beijing Nanyuan||13.5 km|
|Beijing Capital||24.5 km|
|Luanping Erdaogoumen||125.7 km|

domain: travel


text:
Sports betting as the title itself implies is exactly about betting on a specific sports activity, no matter if it’s football, basketball, tennis, ice hockey, rugby or perhaps perhaps the fantastic super bowl. With the birth of the web it’s currently easy for one to bet on the favorite sport of theirs without needing to leave the convenience of the home of theirs.
You will find a great deal of 토토사이트 on the net ready as well as prepared to put the bets of yours. Before you decide to make up your mind on any specific bookmaker to place the bets of yours you must do some investigation to see which ones are actually regarded as the finest & most dependable, particularly in terms through payouts.
Today lets check out just how sport betting truly works. To begin with the bookmakers would do a detailed research of the different sporting events and after thoroughly thinking about the odds as well as time play would put a summary of odds for every gaming actually on the sites of theirs for their potential customers to discuss. The potential bettors would then examine this list & consider all of the possible odds of each game prior to placing the bets of theirs.
Generally they will go with the bookmaker that appears to be providing the very best odds. The chances of any sport betting occasion is able to change at any time throughout the game, thanks to different factors including time play remaining, scoring and absence of a star player.
To put a bet with an internet bookmaker, you’ll initially need to develop an account with the internet sports organization of the choice of yours. Many techniques of Payments & Deposits are often carried out via Online transaction or credit Cards facilities for instance PayPal, Click2Pay, e Check, e Wallet, simply to name just a few.

domain: sports


BUCKHORN, N.C. — Volunteers joined with the North Carolina Wildlife Resources Commission (NCWRC) this past summer to continue a long-term habitat enhancement program on Shearon Harris Reservoir, commonly recognized as the state’s premier bass fishery. With financial assistance from the federal Sport Fishing Restoration Program, workers planted native aquatic vegetation as well as installed artificial structures.
“We had good volunteer turnout and two good weeks of work,” said biologist Clint Morgeson, who noted that Bill Frazier, North Carolina’s B.A.S.S. Nation Conservation Director, was an important part of the effort.
“Not only has he been involved in the Harris Lake Stakeholder Group, Bill helped build exclosures and plant vegetation,” Morgeson added.
When the habitat work began in 2018, Frazier said, “One of the main goals was to get input from fishermen. We did. Most of the best features we scouted already had some fishermen’s ‘enhancements’ on them. NCWRC got a lot out of the learning experience.”
The North Carolina biologist echoed that appraisal and said that it continued in 2019. “Where we put habitat came from anglers,” he said. “We believe that those decisions should be made by people using it (Harris Lake) rather than managing it.”
The agency began habitat enhancement just before the Division of Water Resources started a hydrilla control program, which included 4,000 grass carp, as well as herbicides. Because of so many boats going in and out of Harris and its proximity to other fisheries, resource managers feared the invasive plant might be spread “where the long-term environmental and economic impacts can be devastating,” according to NCWRC.
At Harris, meanwhile, the fast-growing plant favored by both bass and bass anglers was on the decline naturally before control efforts began.
“In the 90s, it was like a bathtub topped out with hydrilla,” Morgeson said, adding that it had diminished to 942 acres for the 4,100-acre impoundment by 2015 and, by 2018, it was down to 230 acres.
And that’s not necessarily a bad thing, according to Frazier.
“Harris has long been known as a trophy bass fishery, but gets characterized for the role of vegetation inaccurately,” he said. “The guides don’t advertise it, but spend most of their time offshore.
“That is where the bigger fish are caught and the NCWRC project very strongly favored putting artificial habitat in these areas.”
In keeping with that, Morgeson suggested anglers might want to “adjust their tactics.”
This past summer, staff and volunteers, who included workers from Harris Lake County Park and North Carolina State Bass Pack, placed 150 polytrees, 100 spiderblocks and 20 Shelbyville cubes, variations of the original Georgia cube.
“We used the Fishing Trail of North Carolina concept to set them at the best possible locations on features at or above the thermocline,” said Frazier, adding that locations are available on the NCWRC website.
They also planted vegetation, as well as built and placed exclosures to keep grass carp and turtles from eating it. Morgeson estimated that 900 plants of “nine to10” species were utilized, including Illinois pondweed, spatterdock, and bulrush within the exclosures and water willow and pickerel weed outside.
In 2018, the agency reported, “Staff initially planted native vegetation at 14 sites and installed 50 artificial fish attractors in the lake. Biologists hope to establish approximately 30 acres of artificial and natural structures and approximately 1 acre of founder colonies of native vegetation plants once the project has been completed.”
Meanwhile, news already is positive, according to Morgeson, who said he’s receiving reports that fish are showing up on attractors. He added that he’d like for more anglers to use social media to let the agency know about their experiences. He also welcomes suggestions for habitat placements.
Biologist Clint Morgeson can be contacted at (919) 707-0339 or email@example.com. Here’s a link to NCWRC fish attractor map.


Since 1989, an inventor named Danny Hillis has been working on a truly mind-boggling project – a 500-foot-tall (152-meter-tall) solar-powered clock inside a mountain in West Texas that is designed to keep time for 10,000 years, with minimal maintenance or interruption. In an article published in American Astronomical Society in 2012, Hillis and colleagues described the plan for the device, which will maintain its long-term accuracy by synchronizing to the sun through heating of a sealed chamber of air by a beam of sunlight that shines into it at solar noon.
Bezos recently created a stir on Twitter when he posted a time-lapse video to announce that the clock is now in the installation phase.
In an undated blog post on the 10,000 Year Clock website, Bezos explains that he's been helping with the project for years because "As I see it, humans are now technologically advanced enough that we can create not only extraordinary wonders, but also civilization-scale problems. We're likely to need more long-term thinking."
No word yet on when the clock actually will be completed and operational.


text:
How To Use OR-benchmark
The following examples will show you how easy OR Benchmark can be used:
OR-Performance - Finding l
Compared with Hospital B, Hospital A(left) has a lot more OR procedures in the evening i.e. outside the core working time (brown segment). This leads to overtime and unhappy staff.
OR-Utilization - Finding II
As you can see from the pie chart, work at Hospital A starts later than at B (dark red segment). This causes waiting times which cost money and leads to frustration among staff.
Idle Time – Diagnosis
Bad capacity planning is typically characterized by work starting late in the morning (left). And we often see a pattern in which idle time alternates with overtime, usually in the evening (right).
Reducing idle time and overtime lead to improved economic outcome.
Therapy: Reorganization of patient logistics to and from the OR. After six months success was clearly measurable.

domain: medical


text:
Track calories carbs fat sodium sugar 10 other nutrients. Dairy queen nutrition facts.
dairy queen nutrition facts pdf is a free HD wallpaper sourced from all website in the world. Download this image for free in HD resolution the choice "download button" below. If you do not find the exact resolution you are looking for, then go for a native or higher resolution.
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Get nutrition information for dairy queen items and over 175000 other foods including over 3000 brands.
Dairy queen nutrition facts pdf. Since 1940 our fans have come to expect the best from their neighborhood dairy queen store. Well the chart below will help you find nutritional information about dairy queen menu items. Dairy queen nutrition facts calorie information a nutrition guide to the dairy queen menu for healthy eating.
Nutrition dairy queen dairy queen blizzard nutrition chart pumpkin dairy queen nutrition information and calories full menu dairy queen nutrition information and calories full menu. About the author jen yilma. Nutrition information is based on analysis by r tech and commercial testing laboratory inc and representative values from manufacturers genesis rd sql and health canada.
Select any item to view the complete nutritional information including calories carbs sodium and weight watchers points. Seasonal and manufacturer. Find out all the nutritional information using our allergy guide and nutrition calculator.
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Its still that way today from our classic treats to the new favorites youve. Whats people lookup in this blog. The dietary guidelines for americans recommend limiting saturated fat to 20 grams and sodium to 2300 mg for a typical adult eating 2000 daily.
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domain: food


Lightning Up: A Guide to Using Bitcoin’s Lightning Network
The Lightning Network is a scaling solution for Bitcoin that enables fast and cheap bitcoin transactions. It's a revolutionary technology with the potential of increasing Bitcoin's adoption.
But how does it work?
And how can you take advantage of its incredible speed and efficiency?
In this blog post, we'll explore the Bitcoin Lightning Network in detail. We’ll cover
- How to set up and fund your lightning network wallet
- Using lightning network channels
- How to send and receive payment on the lightning network
- And how to stay safe on the lightning network
What is the Bitcoin Lightning Network
The Bitcoin Lightning Network is a layer 2 technology built on top of the Bitcoin blockchain, allowing for faster and cheaper transactions. It is an off-chain scaling solution that enables users to create a secure and private channel between two or more parties to send and receive Bitcoin with near-instantaneous speed and minimal fees.
Unlike traditional Bitcoin transactions, which are limited by the block size and transaction throughput, the Lightning Network allows you to send and receive bitcoin without waiting for confirmation on the blockchain. This means that it can handle a much larger volume of transactions than the Bitcoin blockchain.
How does the Lightning Network work?
When two users wish to send or receive bitcoin via lightning, they create a payment channel, and each deposit an amount of bitcoin into the channel via a multi-signature wallet. This wallet is controlled by both parties and can only be unlocked by a mutual agreement.
Once the wallet is created, they can send and receive bitcoin between each other as long as the total amount of bitcoin in the wallet never exceeds the amount of bitcoin initially deposited.
Setting up a Lightning Network Wallet
There are several types of wallets available for the Lightning Network. Some of the most popular are BitMask wallet, Blixt wallet, Phoenix wallet, Breez wallet, Wallet of Satoshi.
BitMask is a bitcoin wallet (also available as a browser extension) for accessing decentralized web applications on the Bitcoin blockchain. It is created by DIBA and gives you the option of a taproot-enabled Bitcoin and Lightning Network wallet. You can also use BitMask to collect and trade Unique Digital Assets (UDAs) on the DIBA marketplace.
How to Set Up a Lightning Network Wallet
Setting up a Lightning Network wallet is a straightforward process.
- Choose a bitcoin lightning wallet that suits your needs
- Download and install the wallet application to your device
- Add Bitcoin to open a new channel and have outbound liquidity if the wallet is self-custodial.
- Depending on which wallet you are using you should follow the instructions to backup your wallet correctly.
Funding Your Bitcoin Lightning Network Wallet
The most common way to fund your Lightning Network wallet is by sending bitcoin from an existing wallet. You can also buy bitcoin with a credit or debit card and send it to your Lightning wallet. Some services also allow you to buy bitcoin directly with your Lightning wallet.
When funding your Lightning Network wallet, it’s crucial to use a secure means. For extra security, always use a hardware wallet or software wallet that you control.
It’s important to make sure you’re buying bitcoin from a reliable source. Also, double-check the address you’re sending bitcoin to for correctness as inputting the wrong address could result in a permanent loss of funds.
Using Lightning Network Channels
Lightning Network channels are a type of payment channel that facilitates transactions off the blockchain. All transactions within a channel are kept private to the channel. Only the opening and closing transactions of a channel are broadcasted to the blockchain.
**How to Open and Close a Channel **
To open a channel, the two users must agree to set up a payment channel between them, and each fund the channel with the amount of bitcoin they want to use for transactions.
To close a channel, one of the users must broadcast a closing transaction to the blockchain and this will settle the final balance in the channel.
Making and Receiving Payments on the Lightning Network
It’s relatively easy to make and receive payments on the Lightning Network.
To make payments, you need to open a payment channel with the recipient by depositing some bitcoin in a two-party, multi-signature wallet. Once the channel is open, you and the recipient can transact an unlimited number of times off the blockchain.
To receive payment on a Lightning Network wallet, first, you’ll need to generate a unique invoice from your wallet. Once the invoice is created, the sender can scan the QR code or copy the invoice and send the payment.
Different Payment Methods Available on the Lightning Network
The Lightning Network supports a variety of payment methods. You can choose between traditional bitcoin payments or you can use a third-party payment processor.
Third-party payment processors such as OpenNode make it easy to send payments with other currencies, such as USD, EUR, and GBP. These payment processors also make it easier to receive payments from customers who don’t have a bitcoin wallet.
Staying Safe on the Lightning Network
Lightning Network relies on Bitcoin’s principle of peer-to-peer transactions which means there’s no central authority to enforce trust on the network. Also, funds sent to the wrong invoice or a malicious actor can not be recovered.
You can take the following measures to stay safe on the Lightning Network
- Only transact with trusted parties and research any person or organization to verify their status
- Always double-check payment invoices before sending funds
- Use a watchtower service to monitor your channels for fraudulent activity
- Add two-factor authentication (2FA) to complement your passwords
- Always use the latest version of your wallet as an outdated version can make you vulnerable to hacks
The Lightning Network is a robust technology for making fast and cheap bitcoin transactions. With just a few steps, you can create your wallet, fund it, and start sending funds over Lightning Network channels. It is important to understand how to use it properly, as there are different wallets available for the Lightning Network, each having its advantages.
To get started, get the BitMask wallet extension to enjoy the efficiency of this exciting layer 2 technology!


24 Oct 2017 14:50pm
WINDHOEK, 24 OCT (NAMPA) Deputy Prime Minister, Netumbo Nandi-Ndaitwah has assured the public that Namibia has ceased all relations with North Korea, in conformity with the United Nations (UN) sanctions on the Asian nation.
Nandi-Ndaitwah, who is also the minister of International Relations and Cooperation, made the remarks in a media statement on Tuesday in reaction to a widely circulated Cable News Network (CNN) news clip on the matter.
The video clip highlights Namibias alleged connection with North Korea, especially in the construction industry where the country benefited from North Korean constructors for most of its top priority projects.
Projects highlighted by the report, in which North Korean giant Mansudae Overseas Projects was involved, include State House in Auasblick; work on the Independence Museum in the town centre and the Heroes Acre outside Windhoek.
Following the circulation of the video clip, in which the deputy prime minister was also interviewed, speculations have been rife that Namibia could face sanctions from the UN for its links with the country.
Nandi-Ndaitwah said in the media statement that Namibia has drastically cut its links with North Korea, as witnessed by the halting of projects and work in which the Koreans were involved in, and their eventual departure from the country.
She said this will be the status quo for as long as the UN sanctions against North Korea are in place.
Nandi-Ndaitwah said Namibia has been submitting regular reports to the UN Security Council Sanctions Committee on North Korea as required, with the last report being on 08 April 2017.
The deputy prime minister said the assertion in the CNN news clip that such reports have been outstanding for more than a year, was therefore false.
The Government of the Republic of Namibia is committed to comply with all relevant UN resolutions on the Democratic People's Republic of Korea (DPRK) and has, therefore, invited the panel of experts to visit Namibia to assess its compliance with the UN Security Council sanctions, resolutions on the DPRK, she said.
Nandi-Ndaitwah said the committee acknowledged Namibias invitation, but could not make the trip as their calendar could not allow them to visit Namibia. The invitation still stands, she said.
The United Nations Security Council unanimously adopted a US-drafted resolution to impose new sanctions on North Korea at the beginning of September this year, merely a week after the Asian nation carried out its sixth and largest nuclear test.
The resolution, according to media reports, is designed to accomplish six major goals: cap North Korea's oil imports, ban textile exports, end additional overseas labourer contracts, suppress smuggling efforts, stop joint ventures with other nations, and sanction designated North Korean government entities.


On July 15, 2010 City Council held a public hearing and discussed moving forward with initiating the Mirror Lake historic district application. Leading up to the hearing, Council received more than 400 emails in support of starting the district designation process. At the multi-hour public hearing, individuals spoke both for and against district designation. City Council ultimately voted unanimously to continue their discussion to October 14. A thumbs up to Council members Driscoll, Rice and Figgs-Sanders who spoke at length in support of starting the district process.


Work place: Information Science and Engineering, Canara Engineering College, Mangalore
Research Interests: Analysis of Algorithms, Mathematics of Computing, Theory of Computation, Models of Computation
Navaneeth Mallya is currently pursuing his B.E. degree in Department of Information and Science, Canara Engineering College, Karnataka, India. His area of interest is Internet of Things.
DOI: https://doi.org/10.5815/ijem.2021.04.04, Pub. Date: 8 Aug. 2021
This project is focused on developing a Fully Automatic Hydroponics system which helps in monitoring and controlling temperature, Humidity, pH and EC in Hydroponics. Hydroponics is a method of growing crops without soil. Plants are grown in rows or on trellises, just like in a traditional garden, but they have their roots in water rather than in dirt. Although, there are different ways in which hydroponics can be implemented, there is no individual system which can measure and control pH and EC level of nutrient solution along with its surrounding temperature and humidity automatically. We use PIC16F877A microcontroller and four pumps, three of which are used to pump water, nutrient solution, pH solution and the fourth pump is used to control the humidity. A fan is used to control the temperature which increases its speed as the temperature increases. The pumps are turned on depending on the EC and pH values obtained from the electrodes. A passive LCD display is used to display variations in the values. Different Analysis like water usage, plant growth in comparison with regular farming method and hydroponics is successfully completed which results in hydroponics system is significant method in comparison with soiled cultivation method in terms of yield and water usage. This project is expected to produce high yield crops by taking minimal space, makes work easier for farmers in growing of plants, and also consumes less amount of water when compared to traditional method resulting in conservation of water.[...] Read more.
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The parents of a baby girl who underwent lifesaving surgery when she was just a few hours old have raised £3,775 for The Sick Children’s Trust as thanks for supporting them with free ‘Home from Home’ accommodation.
Daisy Baldwin, 25, and Will Wakefield, 26, from Leigh-on-Sea, organised a fundraiser at Barru Bar and Kitchen on Saturday 10 February to thank the charity for keeping them by their daughter’s hospital bedside when she required major surgery at The Royal London Children’s Hospital – miles away from home.
When Daisy and Will went for their 12 week scan they were devastated to find out that there was something wrong with their baby, Nelly. Doctors at Southend University Hospital told the worried parents that Nelly had developed a condition known as gastroschisis, a developmental defect where the abdominal wall does not develop completely so the intestines develop outside of the body. Mum, Daisy, who works for global consulting firm North Highland, says:
“It was devastating to find out that there was something wrong with Nelly and so worrying to know that she would need an operation as soon as she was born. But the doctors reassured Will and me that there were no other complications and that Nelly would be delivered at King’s College Hospital so she could receive the necessary care. However, Nelly arrived early at 34 weeks and there wasn’t a cot at King’s College Hospital so we were transferred to The Royal London Hospital instead.
“Within 12 hours of being born Nelly’s intestines were put back inside her body and she was placed on the neonatal intensive care unit (NICU). The hospital was so far from our home and the thought of being separated from Nelly during a huge time of uncertainty was very scary, but the nurses on NICU put us in touch with The Sick Children’s Trust. The charity runs a place called Stevenson House which was located just minutes from Nelly’s bedside and we were told we could have a room there. It was a real lifeline for us.”
The Sick Children’s Trust runs ten ‘Homes from Home’ across the country, supporting families like Nelly’s with free accommodation whilst their child is being treated in hospital. Daisy and Will stayed at Stevenson House for six weeks. Now, six months on Nelly is thriving and to celebrate her speedy recovery and thank The Sick Children’s Trust, her parents held the fundraiser.
The couple had already raised over £2,000 before the event, but on the night raised a further £1,775 having sold around 100 tickets at £7 each. Daisy adds:
“It was such a great evening and everyone was so generous all night long. I would like to thank local DJ Dan Barnes, double glazing installer, Windowfix, who provided the food and all those who donated amazing prizes to the raffle.
“While having an amazing night, everyone who came along learnt a little bit more about The Sick Children’s Trust and the vital work the charity does around the country which is what we hoped for.”
The Sick Children’s Trust relies entirely on voluntary donations and it costs the charity £30 to support a family for one night. Vicki Roots, Community Fundraising Officer at The Sick Children’s Trust, says:
“Thanks to Daisy and her kind family and friends, they have covered the cost of 125 nights of accommodation across our ten ‘Homes from Home’ which we are so grateful for. As a charity, it costs £30 to support a family for one night in a ‘Home from Home’ so their efforts will help us to support many other families who have a seriously ill child in hospital.
“We are delighted that Nelly is now doing so well and that her family are on a mission to fundraise for us!”
To support Nelly’s family on their fundraising mission, please visit the Just Giving page: https://www.justgiving.com/fundraising/daisy-baldwin1
For further information about The Sick Children’s Trust, please visit: http://www.sickchildrenstrust.org
Press release distributed by Pressat on behalf of The Sick Children's Trust, on Monday 12 March, 2018. For more information subscribe and follow https://pressat.co.uk/


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The whole concept of Lizzie Borden’s home turned into a bed-and-breakfast museum seems like something Supernatural might conjure up.
Except, it’s real. Really. Look it up. If you’re like Sam, you can totally geek out and actually spend a night at the infamous accused axe murderer’s abode in Fall River, Massachusetts.
Me? I’ll pass and stick to watching the Winchesters check the area out from the comfort of my own place.
Granted, with Supernatural Season 11 Episode 5 playing up the ghostly vibe and tension as Sam and Dean tackled the case of the week, I definitely felt like I got a real taste of the residence.
And I was actually looking forward to seeing the brothers take on a haunting, as it’s felt like a while since their last ghost hunt. The outset of their search was definitely creepy from the music to the darkness of the place as they slowly walked around. I even expected a jump scare, but one never came.
Instead, the brothers were able to debunk the mystery, discovering sound systems and lights set to flicker on a timer or even a machine that would make an EMF meter go off.
It was a solid twist, but it didn’t quite answer the reason for the murders.
Then as the murders around town started stacking up, I began to wonder if Sam and Dean were actually going to be just trying to stop some crazy human serial killer.
Remember Supernatural Season 4 Episode 11, “Family Remains”? What the brothers thought to be a ghost turned out to be a crazed human.
So it was a clever and solid turn when the seemingly case of the week turned out to be connected to the Darkness. This wasn’t just some throw away episode that was scary and solved by the end. And it was good to see that the hour didn’t devolve into some cheesy or campy mess.
It really zeroed in on the Darkness growing, its affect on others, and how losing a soul can be very different for everyone.
I was trying to figure out who the actual killer would be through Scooby Doo process of elimination, but I didn’t guess the babysitter until pretty much the reveal.
But it was odd to see her embrace the Darkness with such gratitude and worship. It’s kind of scary to think that the Darkness could do that to all of humanity.
Though, if there are others out there like Len, people who’ve lost their soul but can still find a way to do good, then there might be hope. Maybe?
It really makes me interested in what the Darkness is planning as she greedily gobbles up souls. She certainly seems eager to see Dean soon enough.
At least the brothers seem to be working together well enough that they can take on the Darkness as a team. And maybe Castiel will be able to help?
I’m still not sure what the writers plan on doing with Castiel, but with Sam’s explanation that he was binge watching The Wire, I’m willing to let my concerns slide for now because, well, it’s The Wire.
Let’s just hope Castiel doesn’t spend all season doing Netflix and chill though.
That said, putting Sam and Dean at the core focus of the hour felt like some old school Supernatural. And I love that they are trying to keep on their new rules path, too.
This was an entertaining episode that found a solid way to put the brothers on the trail of their monster of the week while incorporating the bigger story. It's good to see Supernatural Season 11 off to such a positive start.
What do you think is the Darkness' plan? Did you think it was a ghost at the Borden house? Sound off below, and don't miss any Sam and Dean cases when you watch Supernatural online now.
Note: Supernatural Season 11 Episode 6, "Our Little World," airs Nov. 11 at 9 p.m.
Sean McKenna was a TV Fanatic Staff Writer. He retired in May of 2017. Follow him on Twitter.


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The Egyptian Center for Public Opinion Research (Baseera) conducted a telephone survey aimed at estimating the prevalence of coronavirus infection among Egyptians over 18 years old. The results showed that an estimated 616,000 individuals have been infected.
Baseera explained that the rate of infection determined by the survey may be even lower than the actual rate, due to the fact that some patients don’t report having been infected, either because they feel that the infection may constitute a stigma for them, or because the symptoms were mild and they, therefore, didn’t recognize their illness as COVID-19.
The center added that on the other hand, the figure reported may be greater than the true rate, because coronavirus symptoms are similar to those of other diseases, including influenza. Some people may, therefore, think they had coronavirus, but in fact, they fell ill with something else.
The results of the survey also depended on the respondents’ self-diagnosis, and not a more accurate clinical diagnosis, the center added.
The survey included, however, simple, moderate, and severe cases, whereas official records usually only include the most severe cases, Baseera reported.
According to the survey, an estimated 616,000 Egyptian respondents above 18 years of age have contracted the virus, 12 percent (74,000) of whom were admitted to quarantine hospitals — a number that is close to the official figure announced by the Health Ministry.
According to the survey, 66 percent of respondents resorted to home quarantine, 39 percent followed up on their cases with doctors at home, and 61 percent took medication.
Baseera attributed the low percentage of people who went to hospital to the fact that a large number of patients showed minor symptoms.
According to the survey, three percent of cases showed one symptom, 18 percent showed two symptoms, while the rest of the cases showed three symptoms or more.
Among those infected, 67 percent reported fever, 37 percent reported a severe cough, 39 percent reported vomiting and diarrhea, 31 percent reported congestion or pain in their throat, 13 percent reported the loss of smell or taste, and 13 percent reported stomach pain.
Baseera added that the prevalence rate reached 14 per thousand in the country’s urban population, compared to eight per thousand in the rural population.
Those who admitted to or were aware of having been infected reached 16 per thousand among those with university degrees, compared to eight per thousand among those with lower education degrees.
Respondents were also asked to recall the methods by which they were diagnosed.
The survey indicated that 15 percent of infections were diagnosed using swab tests, 29 percent via a blood test, 38 percent via chest x-rays, and 23 percent via a doctor’s examination. Sixteen percent of people, meanwhile, stated that they relied on self-diagnosis.
The center pointed out that when respondents were asked if any other members of their household had caught the disease as well, 21 percent said that at least one other member of their family had been infected, while 56 percent said that the rest of their family members had not been infected, and 23 percent answered that they did not know.
The survey was conducted from June 8 to 18, 2020 using landline phones and mobile phones and a sample of 3,017 citizens aged 18 years or older in governorates around the country.
The response rate was about 55 percent, and the margin of error in the results was less than three percent. The survey was conducted with self-financing from Baseera center.
Edited translation from Al-Masry Al-Youm


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“Do The Right Thing!” Each day, Merriman’s Restaurants strive to “Do The Right Thing!” for the earth, for each other and for our guests.
Mission Statement: “Do The Right Thing!” Each day, Merriman’s Restaurants strive to “Do The Right Thing!” for the earth, for each other and for our guests.
Our Commitment: Merriman’s Restaurants are driven by our long-standing commitment to Hawaii Regional Cuisine. We support local farmers, ranchers and the local economy while offering fresh, authentic regional cuisine at its peak flavor.
At Merriman's our pledge is: Continue to support local farmers who choose sustainable agriculture methods that nourish the earth so it is rich and fertile for future generations.
"We hope you too are inspired to support local farmers and a healthy Hawaii through Hawaii Regional Cuisine." - Peter Merriman
Donations / Fundraisers: At Merriman’s we believe in sharing our success. For over 25 years, we have been dedicated to giving back to our local communities. Every year each Merriman’s Restaurant donates to multiple non-profit organizations within their communities through charity dinners, gift certificate donations, fundraisers and participation in local charity events. Each restaurant location also hosts annual anniversary fundraisers, celebrating the number of years the restaurant has been in business and supporting the local community at the same time.
"Hawaii has been good to us, and we want to be good to Hawaii" – Peter Merriman


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Thousands march for gun control in Washington
WASHINGTON - Thousands of people have gathered in front of the Capitol for a march on Washington for gun control.
Marchers were led by Mayor Vincent Gray and other officials Saturday morning, and the crowd stretched for about two blocks along Constitution Avenue. Police blocked off half the road.
Participants held signs reading "Ban Assault Weapons Now" and "Gun Control Now." Other signs carried names of victims of gun violence.
About 100 residents of Newtown, Conn., were expected at the march. It was organized in response to the December shooting there that killed 20 first-graders and six teachers.
Kara Baekey of Norwalk, Conn., she immediately thought of her two young children when she heard about the shooting. She said she decided she must take action, and that's why she joined Saturday's march.
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GREAT Reads is Moray libraries’ summer reading challenge for 2019, aimed at encouraging primary school children to enjoy reading books throughout the holidays.
Those wanting to take part need to be a member of the library service – it’s simple and free to join – sign up for the challenge, borrow six books and tell us about them as they go.
On completion they’ll receive a ‘golden ticket’ invitation to meet a children’s author at a prize-giving ceremony later in the year.
Kids can sign up from the last day of term (28 June) and have until 31 August to complete the challenge. There are many books for children at Moray’s libraries. Register today to start enjoying some Great Reads!
Famous for its colony of dolphins, fabulous beaches and more malt whisky distilleries than any where else in Scotland, Moray is a thriving area and a great place to live. Nestling between Aberdeenshire and the Highlands, Moray stretches from Tomintoul in the south to the shores of the Moray Firth, from Keith in the east to Brodie Castle in the west.

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