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Therefore, when you’re following a ketogenic diet plan for beginners, your body is burning fat for energy rather than carbohydrates, so in the process most people lose weight and excess body fat rapidly, even when consuming lots of fat and adequate calories through their daily food intake. Another major benefit of the keto diet is that there’s no need to count calories, feel hungry or attempt to burn loads of calories through hours of intense exercise.
Great list! These apps will be very helpful on monitoring and motivating us to stay on the course of fitness. With great sets of exercises and right food plus these apps, this year will really squeeze some fats out of us. On the side of right exercises to burn fats and lose some weight, I found this link very practical and helpful: https://www.drberg.com/blog/most-popular/the-best-fat-burning-exercise
• Your body is still growing — In one study, epileptic children experienced a reduction in symptoms and improved cognitive performance when a ketogenic diet was introduced.49 However, this may have a negative effect on the growth of their bodies in the long run, according to a study published in the journal Developmental Medicine & Child Neurology.50
Recently, many of my patients have been asking about a ketogenic diet. Is a ketogenic diet safe? Would you recommend it? Despite the recent hype, a ketogenic diet is not something new. In medicine, we have been using it for almost 100 years to treat drug-resistant epilepsy, especially in children. In the 1970s, Dr. Atkins popularized his very-low-carbohydrate diet for weight loss that began with a very strict two-week ketogenic phase. Over the years, other fad diets incorporated a similar approach for weight loss.
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This fat burner is pretty amazing if you put in the work. It decreases my appetite so I've found that I only eat about half portions at mealtimes. I eat kind of healthy but I do not stick to a strict or specific diet. I purchased this on dec 8th and started using it around the 13th and it gave me energy to workout and even just do household tasks. When I started I weighed in around 158-160. I had previously been prescribed phentermine but I was looking for something a little less expensive. I wanted to lose 10 more pounds and figured I could do so with a bottle of this. I weighed in this morning and I am 150.2 I don't workout everyday but this has really controlled my appetite which has always been my biggest issue. So my advice is Try it! It's at a great value to try out because it really helped me lose that last stubborn few pounds.
An addiction to diet pills is often caused by an eating disorder or other underlying mental health disorders. Becoming dependent on diet pills is not uncommon, as they can provide a false sense of control in a life that seems out of control. Because diet pills are readily available over the counter or by prescription, an addiction can develop quickly and quietly.
Many celebrities including Christina Milan, Hilary Duff and Vanessa Hudens drink and promote the best detox tea brands for a flat tummy and gorgeous skin and hair. Naturally, all this has created a buzz around various slimming tea brands but you are going to be in for a huge disappointment if you think that you will look like them just by drinking detox teas. Naturally, you must workout; stay hydrated and eat fewer carbs alongside drinking these healthy teas to actually see results.
Losing weight isn't about not eating certain foods, it's about eating better-for-you foods. Fooducate makes deciphering confusing nutrition labels easy — simply scan the bar code on the packaging and the app spits out a grade for the product, and tells you if there are not-so-nice ingredients like added sugars, MSG, additives and preservatives that you'll want to skip. After all, the more high-quality food you put into your body, the better you'll feel overall.
Amphetamines (marketed as Benzedrine) became popular for weight loss during the late 1930s. They worked primarily by suppressing appetite, and had other beneficial effects such as increased alertness. Use of amphetamines increased over the subsequent decades, including Obetrol and culminating in the "rainbow diet pill" regime. This was a combination of multiple pills, all thought to help with weight loss, taken throughout the day. Typical regimens included stimulants, such as amphetamines, as well as thyroid hormone, diuretics, digitalis, laxatives, and often a barbiturate to suppress the side effects of the stimulants. In 1967/1968 a number of deaths attributed to diet pills triggered a Senate investigation and the gradual implementation of greater restrictions on the market. While rainbow diet pills were banned in the US in the late 1960s, they reappeared in South America and Europe in the 1980s. Eventually rainbow diet pills were re-introduced into the US by the 2000s and led to additional adverse health effects.
Meridia (sibutramine) is an appetite suppressant product that was removed from the market in the United States in 2010. The FDA initially approved the product, but the manufacturer stopped producing it after clinical studies showed that users had an increased risk of heart attack and stroke. The National Institutes of Health (NIH) recommends that anyone still using Meridia contact their physician to discuss alternative treatments.
In the United States orlistat (Xenical) is currently approved by the FDA for long-term use. It reduces intestinal fat absorption by inhibiting pancreatic lipase. Rimonabant (Acomplia), a second drug, works via a specific blockade of the endocannabinoid system. It has been developed from the knowledge that cannabis smokers often experience hunger, which is often referred to as "the munchies". It had been approved in Europe for the treatment of obesity but has not received approval in the United States or Canada due to safety concerns. The European Medicines Agency in October 2008 recommended the suspension of the sale of rimonabant as the risks seem to be greater than the benefits. Sibutramine (Meridia), which acts in the brain to inhibit deactivation of the neurotransmitters, thereby decreasing appetite was withdrawn from the United States and Canadian markets in October 2010 due to cardiovascular concerns.
Use fat as a lever. We’ve been taught to fear fat, but don’t! Both keto and low carb are high fat diets. Fat is our source of energy as well as satiety. The key to understand, though, is that fat is a lever on a low carb or keto diet. Carbs and protein stay constant, and fat is the one you increase or decrease (push the lever up or down) to gain or lose weight, respectively. So if your goal is weight loss, eat enough fat to be satisfied, but there’s no need to “get your fats in” once you’re satisfied.
To get the most benefit from the Keto diet, you should stay physically active. You might need to take it easier during the early ketosis period, especially if you feel fatigued or lightheaded. Walking, running, doing aerobics, weightlifting, training with kettlebells or whatever workout you prefer will boost your energy further. You can find books and online resources on how to adapt Keto meals or snacks for athletic training.
Born from leaves and twigs of the yerba mate plant, this South American weight-loss tea is rife with stimulating chemicals like caffeine, theophylline, and theobromine. In a study in animals that ate a high-fat diet, those that consumed yerba mate had lower blood sugar levels and didn’t gain as much weight as those that didn’t consume the drink. Plus, obese people taking an yerba mate supplement for 12 weeks lost more fat compared to a placebo group, in a 2015 study in the journal BMC Complementary and Alternative Medicine. Yerba mate is considered a substitute for coffee—without the bitterness—so try it in place of your morning Joe tomorrow. (Consider these fat-releasing habits to help you slim down.)
The popular low-carb diets (such as Atkins or Paleo) modify a true keto diet. But they come with the same risks if you overdo it on fats and proteins and lay off the carbs. So why do people follow the diets? "They're everywhere, and people hear anecdotally that they work," McManus says. Theories about short-term low-carb diet success include lower appetite because fat burns slower than carbs. "But again, we don't know about the long term," she says. "And eating a restrictive diet, no matter what the plan, is difficult to sustain. Once you resume a normal diet, the weight will likely return."
Risks: The FDA in 2017 reported five deaths that may have been caused by the intragastric balloons (e.g., perforation of the stomach or esophagus, or intestinal obstruction).The agency also received multiple reports of spontaneous balloon overinflation, either with air or fluid, and acute pancreatitis caused by the balloon pressing on surrounding organs.
Long-term problems following weight loss surgery depend on which type you have. One of the most common issues, especially with gastric bypass, is "dumping syndrome," in which food moves too quickly through the small intestine. Symptoms include nausea, weakness, sweating, faintness, diarrhea after eating, and not being able to eat sweets without feeling very weak. It can occur in up to 50% of people who had weight loss surgery. But avoiding high-sugar foods and replacing them with high-fiber foods may help prevent it.
I have always been what most would consider a “big girl”. In January 2018, I weighed 180 lbs, which is quite overweight for a woman my height. I wasn’t always this weight though. In my teenage years, I weighed only 140 pounds and I felt much healthier and happier. I strived desperately over the years to get back to this weight. But with a stressful and busy work life, I struggled... continue here https://bit.ly/2QNXQm6
Bupropion/naltrexone is a combination drug used for weight loss in those that are either obese or overweight with some weight-related illnesses It combines low doses of bupropion and naltrexone. Both drugs have individually shown some evidence of effectiveness in weight loss, and the combination has been shown to have some synergistic effects on weight. In September 2014, a sustained release formulation of the drug was approved for marketing in the United States under the brand name Contrave. The combination was subsequently approved in the European Union in the spring of 2015, where it will be sold under the name Mysimba.
It is possible to combine the results of several small studies to produce evidence that is stronger than that available from each study alone—a statistical method known as meta-analysis. One of four such analyses, conducted in 2006, looked at 19 studies on a total of 1,084 patients. It concluded that a third achieved an excellent reduction in seizure frequency and half the patients achieved a good reduction.
Phentermine-topiramate is a combination of an anticonvulsant (topiramate) and a weight-loss drug (phentermine). Phentermine has the potential to be abused because of its amphetamine-like effects. Other possible side effects include an increase in heart rate and blood pressure, insomnia, constipation and nervousness. Topiramate increases the risk of birth defects.

domain: medical


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Preparing For A New Pet!
Welcoming a new pet to your family is a big and exciting event! Pets can change our lives in so many ways. Once they wrap their paws around our hearts, we are never the same. Their unconditional love and affection can create bonds that not only change our lives, but also save us in ways we never thought possible.
Before your new furry friend comes into your home, it is important to make the necessary preparations for this exciting and life-changing time. It will not only save you from pulling out your hair, but also from emptying your bank account on furniture replacement!
Do not underestimate the wiley nature of a curious puppy or kitty. They will never cease to both amaze and dismay you. Many pet owners put themselves in a reactionary mode, waiting until things are destroyed around the home, and then taking action to protect other items from being destroyed. For some, their homes end up looking like a disaster zone (why do I hear some men not complaining!).
The following tips will help provide you with a basic understanding of your pet's needs and will go a long way in creating peace and harmony (as opposed to a war zone!) in your home:
Tip #1: Use Playpens & Safety Gates
A child or pet safety gate or adjustable playpen can be a Holy Grail when your pup has you going nuts. They help create a safe space where you can easily keep an eye on them (and they cannot get into mischief). These are available at many stores such as Petco, PetSmart, Target, and Walmart for very reasonable prices. Most are adjustable and can be expanded to accommodate doorways of different widths.
Tip #2: Have Appropriate Toys For Your Pet to Play With & Chew On
This is especially important. Dogs are much more likely to be destructive if they do not have the right toys and they are not encouraged to play with and chew on those toys. Often, pets will chew on no-no's simply because they are bored and don't have enough of their own toys to chew on. From personal experience, I can unequivocally say that a bored Malamute is a destructive Malamute on a mission. Encourage them to chew on their own toys, and if you see them chewing on something they shouldn't, then immediately divert their attention to their own toys and offer lots of praise.
Pay close attention to which toys your pet gravitates too and enjoys the most so that you can stock up on more of them. Some toys may hold no interest to them and will not help keep them occupied. Spend some time helping them explore their toys, and getting them excited about chewing on them.
A great way to keep your pup busy is to purchase a kong, fill it with some peanut butter (human grade, which contains no other ingredient than peanuts, NEVER the spray stuff in a can!), and freeze it. It provides for a very tasty and exciting treat, and keeps them busy for hours.
The artificial peanut butter sold for pets is filled with chemicals that are anything but healthy for your pet. ALWAYS check the ingredient list before purchasing treats. You should see only whole foods listed (except for the addition of natural preservatives).
Let's compare the ingredient list for a healthy peanut butter vs. a spray one that contains unhealthy ingredients:
|Artificial Spray Peanut Butter
|Human-Grade Peanut Butter
Modified corn starch
Sorbic acid (as a preservative)
Caramel color (approx. 50 chemicals)
Annatto extract (color)
Many brands contain ingredients such as sugar, salt, and artificial colorings and flavorings. These are not healthy for you, and are definitely not healthy for your furry friend.
Tip #3: Provide Enough Attention & Playtime
Our new furry members of the family need quality time and attention. Love and affection and bonding are all important key words here. The less attention you give your pup, the more they will try to get your attention (using all sorts of frustrating tactics). Mixing playtime with training is a great way to develop a healthy, strong bond with your pet, and help begin setting boundaries and rules.
Tip #4: Provide Enough Exercise
It is very important to ensure you understand the exercise requirements of your pet. Some dog breeds (such as Labradors, Huskies, Alaskan Malamutes, and Border Collies) are much more active than others are and require a substantial amount of exercise. For these dogs, a 15-minute stroll around the block doesn't cut it.
If your pet does not receive the exercise they need, they are much more likely to become bored, destructive, unfit, and overweight.
Use this daily opportunity to not only provide exercise for your pup, but for yourself too!
Tip #5: Pet-Proof Your Home
Our pets are naturally inquisitive creatures, especially puppies and kitties, sticking their noses into all sorts of unexpected places. Learn which kitchen, bathroom, garage, and general household items pose potential hazards and make sure they are off-limits.
Tip #6: Provide Training
Well-behaved pets are not just "made" - they are trained. Taking the time to train your pet is a very important part of becoming a responsible pet owner. Blaming your dog or cat for its bad behavior when you have not trained them to do otherwise, is not the fault of your pet. That fault lies squarely on your shoulders. Training is not only important for behavior, but it also teaches your pet that you are the alpha and that they need to respect your authority.
Proper training can also save your pet's life in challenging and emergency situations. Paying attention to your commands can prevent a dog from running out in front of a car, harassing or biting a stranger, jumping up on others, or even unintentionally playing too rough with children.
Many companies such as pet stores offer local training classes at very reasonable prices. Private sessions are also available, and it only takes a few sessions to learn the basics. Then it is up to you to be consistent in your daily training. You will be amazed at how quickly your pup will learn if you devote a little time up front (10-15 minutes each day). Begin early, and put both you and your pet on a regular training schedule.
- Healthy & balanced pet diet
- Tips on choosing a healthy pet food
- Home-cooked diet
- Raw food diet for pets
- Doing raw right for pets
- Home-baked doggy treats
- Bones - nature's toothbrush
- Bone broth recipe
- Why pets are getting sicker
- Pet food recalls
- Fleas, ticks, & mosquitoes
- Natural dog grooming
- Pet dental care
- Pet dental kit
- Anesthesia-free teeth cleaning
- Pet vaccinations

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Let’s discuss the question: how are scid and aids similar. We summarize all relevant answers in section Q&A of website Linksofstrathaven.com in category: Blog Finance. See more related questions in the comments below.
What is another name for SCID?
Severe combined immunodeficiency (SCID) is a group of rare disorders caused by mutations in different genes involved in the development and function of infection-fighting immune cells.
What causes the AIDS virus?
HIV is caused by a virus. It can spread through sexual contact, illicit injection drug use or sharing needles, contact with infected blood, or from mother to child during pregnancy, childbirth or breastfeeding. HIV destroys CD4 T cells — white blood cells that play a large role in helping your body fight disease.
Medical Animation: HIV and AIDS
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Is there a cure for SCID?
The only cure currently and routinely available for SCID is bone marrow transplant, which provides a new immune system to the patient. Gene therapy treatment of SCID has also been successful in clinical trials, but not without complications.
What is CID disease?
Combined immunodeficiency — also called combined immune deficiency or CID — is a genetic condition of the immune system. It’s known as a “primary immunodeficiency.” Children inherit the gene for CID from their parents. CID occurs when gene mutations cause defects in the immune system.
How long do kids with SCID live?
What are the survival rates for SCID? Without treatment, infants with SCID usually die from infections within the first two years of life. With an early bone marrow transplant, frequent follow-up and prompt treatment for infections, survival rates are very good.
Why does a bone marrow transplant cure SCID?
The most common treatment for SCID is bone marrow transplant, to introduce normal infection-fighting cells into the child’s body.
HIV \u0026 AIDS – signs, symptoms, transmission, causes \u0026 pathology
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Why is SCID called bubble boy disease?
The name “bubble boy disease” comes from the highly publicized case of David Vetter, who was born in 1971 with SCID-X1, and spent most of his life in a plastic bubble while awaiting a bone-marrow transplant, according to CBS. He died at age 12, after receiving his transplant.
Can adults have SCID?
According to the World Health Organization, there are more than 200 of these sometimes life-altering or life-threatening inherited defects – some are relatively rare, some are quite common. Primary immune deficiency disease affect many thousands of children and adults in the U.S.
Do you inherit your parents immune system?
Scientists say they have found evidence that suggests genetics play a role in immune response, affecting our ability to fight off disease. This is according to a study published in the journal Cell.
What causes a child to have no immune system?
Also, infections such as the flu virus, mono (mononucleosis), and measles can weaken the immune system for a short time. Your immune system can also be weakened by smoking, alcohol, and poor nutrition.
Can kids with SCID go to school?
Both doctors agreed that masks are essential for a safe return to school. Therefore, schools not requiring masks would influence their decision to recommend that a child treated for SCID attend school in person.
SCID (Severe combined immunodeficiency) || symptoms and immunology || Immunodeficiency
Images related to the topicSCID (Severe combined immunodeficiency) || symptoms and immunology || Immunodeficiency
Is SCID life threatening?
Severe combined immunodeficiency (SCID) is very rare genetic disorder that causes life-threatening problems with the immune system. It is a type of primary immune deficiency.
Why are SCID mice used?
What are SCID mouse models typically used for? SCID models are typically used in biology studies of the immune system. SCID mouse models are also used for tumor growth studies and studies of normal and abnormal lymphocyte development and function.
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Over the last 20 years, GAVI and its partners have vaccinated more than 760 million children in 70 countries, thereby saving the lives of more than 13 million.
But in celebrating World Immunisation Week, the worry is that millions of children would be missing out on vaccines against measles, diphtheria and polio.
Even before the coronavirus pandemic, measles, polio and other vaccines were out of reach for 20 million children below the age of one every year.
Given the current disruptions, the UN Children's Fund (UNICEF) has warned that this could lead to disastrous outbreaks in 2020 and well beyond.
GAVI estimates that at least 21 low- and middle-income countries, are already reporting vaccine shortages as a result of border closures and disruptions to travel.
So far, 14 vaccination campaigns supported by GAVI against polio, measles, cholera, human papillomavirus, yellow fever and meningitis have been postponed, which would have immunised more than 13 million people.
The Director-General of the World Health Organisation (WHO), Dr Tedros Adhanom Ghebreyesus, said this week: “The tragic reality is that children will die as a result.”
GAVI has set an ambitious goal to immunise 300 million more children with 18 vaccines by 2025 and to attain this the organisation is looking to raise US$7.4 billion in its upcoming third replenishment that has been scheduled for June.
Dr Tedros said: “We call on the global community to ensure GAVI is fully funded for this life-saving work.
“This is not a cost, it's an investment that pays a rich dividend in lives saved.
“Just as immunisation has been disrupted in some countries, so have services for many other diseases that afflict the poorest and most vulnerable people – including malaria.
“Immunisation is one of the greatest success stories in the history of global health,” he said, adding: “More than 20 diseases can be prevented with vaccines.”
Dr Richard Sezibera, a former Minister of Health in Rwanda, and a long-serving member of the GAVI Board explained in an Op-Ed for the Africa Briefing website earlier this month: “Now more than ever, the need to bring together public and private sectors in strengthening our healthcare systems is being shown.
“With GAVI, this kind of collaboration has been going on for 20 years and is still going strong with the shared goal of creating equal access to new and underused vaccines for children and persons all around the world.”
Dr Sezibera, who is also Chair of GAVI's Programme and Policy Committee, said this year's replenishment was “seeking to build on the historic gains it has made with governments and other partners”.
He added: “We will need to step up with even more.
“Commitments are needed towards increased domestic financing and for recognition of the critical role of vaccines to primary healthcare in Africa, at least for the next period of 2021-2025.”
GAVI said that immunisation campaigns required “a coordinated approach that factors in the unique challenges of each country”.
It added: “For example, in areas with densely populated urban settlements, there may be challenges with communicating the importance of vaccines, so social mobilisation activities are required.
“Conversely, many GAVI-supported countries have very remote regions that demand a new approach to vaccine delivery, like using autonomous drones to efficiently deliver medical supplies.”
The alliance said it was making “health system strengthening grants more flexible to allow countries to reallocate funding towards their COVID-19 response, as well as working with our partners to continue immunisation campaigns where possible”.
“The immunisation infrastructure that GAVI has helped build over the past two decades is also being used to help fight the pandemic,” the organisation said.


The Dassault Rafale, a cornerstone of modern military aviation, has undergone significant advancements over the years. The current Rafale F3R variant marks a substantial milestone in its development, offering enhanced electronic and weapon systems. However, Dassault Aviation is not going to abandon further development of the Rafale, as it has already initiated the development of the Rafale F4 and F5 versions, promising to elevate the aircraft’s capabilities to new heights.
The Present with Rafale F3R
The Rafale F3R represents a significant leap in the evolution of the aircraft. Introduced as an advanced version of its predecessors, the F3R variant brought substantial improvements in electronic systems, weaponry, and overall performance. Key enhancements included the integration of the long-range Meteor air-to-air missile and the Thales RBE2 AESA radar, providing great air-to-air combat capabilities. Additionally, the F3R’s enhanced electronic warfare systems and the SPECTRA defensive suite ensured superior survivability in hostile environments.
Advancing to the Rafale F4
The Dassault Rafale F4 is a significant upgrade in the Rafale fighter series, marking a crucial step in the evolution of this multi-role aircraft. The F4 upgrade is divided into two phases: F4.1 and F4.2, each bringing distinct improvements. The F4.1 level, a pivotal upgrade, signifies a major advancement in capabilities. Certified in March 2023 by France’s DGA defense procurement agency, this upgrade includes advanced equipment and weaponry, enhancing operational effectiveness. Notable additions are the new infrared search and track system (IRST) for Front Sector Optronics and enhancements to the RBE2 AESA radar, improving all-weather, long-range detection and ground target tracking. These improvements are complemented by advancements in network-centric warfare capabilities.
The Rafale F4.2, scheduled for final qualification in 2025, represents further progress, building on the capabilities introduced in the F4.1 standard. It is expected to extend the Rafale’s munitions capabilities, including the ability to carry new and advanced weapons. The integration of new radio and satellite communications will further enhance the aircraft’s communication systems. These improvements, along with ongoing enhancements in electronic warfare, cyber protection, and training simulations, ensure that the Rafale remains a capable multi-role fighter.
Transitioning to 5th Generation with Rafale F5
The Rafale F5, expected to be operational around 2035, represents a transformative upgrade, pushing it towards the capabilities of 5th and, some argue, 6th generation aircraft. This upgrade is set to include the integration of advanced technologies such as the supersonic nuclear missile ASN4G, that is replacing thw ASMP/-A and new cruise and anti-ship missiles from the Franco-British FC/ASW program. A key aspect of the F5 upgrade is its focus on collaboration capabilities with unmanned aircraft, aligning closely with the emerging concept of 6th generation fighters that emphasize network-centric warfare, advanced stealth, and unmanned systems.
In summary, the evolution of the Dassault Rafale from the F3R to the forthcoming F5 model encapsulates a journey of technological mastery and strategic foresight. Each iteration of the Rafale not only cements its status as a potent fighter jet in modern aerial warfare but also showcases Dassault Aviation’s relentless pursuit of delivering reliable planes. As the Rafale transitions through these upgrades, it not only adapts to the ever-changing landscape of military needs but also sets new standards for what modern fighter jets can achieve.
The Rafale’s journey is more than just an upgrade of machinery; it’s a reflection of the evolving nature of aerial warfare, where versatility, advanced technology, and network-centric operations become crucial for air superiority. The Rafale, with its continuous development, is set to remain at the forefront of military aviation, demonstrating the remarkable capabilities of current and future generations of fighter aircraft.


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A panel of the nation’s leading scientists on Wednesday called for more research on climate change and more action to mitigate its effects, including setting a national “budget” to limit carbon emissions.
In a three-part report commissioned by Congress, the National Research Council — part of the National Academies of Sciences — surveyed the state of climate change science as well as what the country is doing to reduce and adapt to the environmental changes it will cause.
The researchers examined newer data than that included in the last major report by the Intergovernmental Panel on Climate Change, which was released in 2007.
They concluded that in order to avoid the most serious consequences, the U.S. needs to keep to a budget of releasing between about 170 billion and 200 billion tons of carbon pollution between 2012 and 2050. That means major cutbacks, because the country now releases about 7 billion tons each year.
Meeting that goal would require developing new technologies, said Robert Fri, a former EPA administrator and the chairman of the committee that wrote the part of the report on mitigating climate change.
“Particularly in the transportation sector, we can’t get there just by deploying what we know how to do,” he said in a briefing.
The report also suggests the U.S. set up a policy framework that would put a price on carbon dioxide pollution, such as a cap-and-trade system or a carbon tax — though it doesn’t recommend a specific method.
A bill that would have enacted a cap-and-trade system passed the House last year but died in the Senate. A similar bill was introduced last week by Sens. John Kerry, D-Mass., and Joe Lieberman, I-Conn.

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Following the electronic and manual searches of bibliographies, forty six clinical studies were identified for inclusion/exclusion assessment (Figure 1). A pre-requisite for the inclusion of clinical studies was identified laboratory evidence explaining the mechanism of effect in reproductive endocrinology. Fifteen met the inclusion criteria [54–68]. Eight were randomised controlled trials (RCTs) including 762 women [61–68] (Table 2). Thirty one studies were excluded for the following reasons; investigation of isolated herbal chemicals (n = 3); inclusion of male subjects (n = 4); no pre-clinical evidence (n = 11) and conditions different to those specified (n = 13).
Polycystic ovary syndrome represents 80% of anovulatory infertility cases. Treatment initially includes preconception guidelines, such as lifestyle changes (weight loss), folic acid therapy to prevent the risk of fetal neural tube defects and halting the consumption of tobacco and alcohol. The first-line pharmacological treatment for inducing ovulation consists of a clomiphene citrate treatment for timed intercourse. The second-line pharmacological treatment includes the administration of exogenous gonadotropins or laparoscopic ovarian surgery (ovarian drilling). Ovulation induction using clomiphene citrate or gonadotropins is effective with cumulative live birth rates of approximately 70%. Ovarian drilling should be performed when laparoscopy is indicated; this procedure is typically effective in approximately 50% of cases. Finally, a high-complexity reproduction treatment (in vitro fertilization or intracytoplasmic sperm injection) is the third-line treatment and is recommended when the previous interventions fail. This option is also the first choice in cases of bilateral tubal occlusion or semen alterations that impair the occurrence of natural pregnancy. Evidence for the routine use of metformin in infertility treatment of anovulatory women with polycystic ovary syndrome is not available. Aromatase inhibitors are promising and longer term studies are necessary to prove their safety.
Clinical equivalence for prolactin lowering effects of Vitex agnus-castus (Agnucaston® 40 mg per day) and the pharmaceutical Bromocriptine (Parlodel® 5 mg per day) was found in one study including 40 women with hyperprolactinaemia . Mean concentrations for prolactin following three months treatment with Vitex agnus-castus was significantly reduced from 946 mIU/l (±173) to 529 mIU/l (±297) (p < 0.001). Comparatively, mean prolactin concentration in the Bromocriptine group was significantly reduced from 885 mIU/l (±178) to 473 mIU/l (±266) (p < 0.001) demonstrating that both treatments were effective treatment for women with hyperprolactinaemia (normal reference range 25-628 mIU/l). The mean difference in prolactin reduction of the two groups was not significant (p = 0.96) (Table 2).
PCOS women with different phenotypes have been found similarly insulin resistant in response to a 3 h 75 g OGTT. Obese (compared to lean) PCOS women tend to have a higher degree of IR. Correlation between hyperandrogenism and IR is significant in many studies but not as significant as the link between insulin abnormalities and obesity. PCOS women demonstrate greater variation in insulin parameters compared to controls, independent of weight. Animal studies of prenatal testosterone exposure show downstream IR in early postnatal life. Some human data shows a high degree of correlation between hyperandrogenism and IR[35,36] and the relationship between hyperandrogenism and IR seem to differ between PCOS and non-PCOS women.
Bragging moment! For the first time in 13 YEARS I'm having a normal period! Bleeding normally, NOT having excruciating cramps, NOT breaking out terribly and my hair is NOT falling out! I am so happy I could cry! The Insulite sytem helped me stay sane and given me my sanity back. I am in control of my body for the first time in my entire life. Truly a blessing.
Other medications with anti-androgen effects include flutamide, and spironolactone, which can give some improvement in hirsutism. Metformin can reduce hirsutism, perhaps by reducing insulin resistance, and is often used if there are other features such as insulin resistance, diabetes, or obesity that should also benefit from metformin. Eflornithine (Vaniqa) is a medication that is applied to the skin in cream form, and acts directly on the hair follicles to inhibit hair growth. It is usually applied to the face. 5-alpha reductase inhibitors (such as finasteride and dutasteride) may also be used; they work by blocking the conversion of testosterone to dihydrotestosterone (the latter of which responsible for most hair growth alterations and androgenic acne).
It’s important to follow-up regularly with your health care provider and make sure you take all the medications prescribed to regulate your periods and lessen your chance of getting diabetes or other health problems. Because you have a slightly higher chance of developing diabetes, your health care provider may suggest that you have your blood sugar tested once a year, or have a glucose challenge test every few years. Quitting smoking (or never starting) will also improve your overall health. Because you have a higher chance of developing diabetes, your health care provider may suggest having a:
Doc ask ko lng po na kung mag diet ang may pcos may posible po bang mabuntis?un po kc sabi ng obgyne d2 sa Japan..wala daw po gamot sa pcos mag diet lng daw po..irreg po kc ang mens ko at matab po ako..tapos po may mga bahid ng blood pero d ko naman po mens un..nag pa check up na po ako..hormomal imbalanced po ang sabi..kaya binigyan ako ng planovar pills para umaayos ang mens ko..mag paalaga din po ako sa doctor para mag kaanak..gus2 ko po payuhan nio po ako kung anong dapat gawin..salamat po
I actually felt really sad for her on a tumblr post once and gave her a spare fiver. the old dude seems to be the light of her life but hes always oding and shes always alone shooting up in public parks. the lack of hygiene seems to be like an "i dont feel human enough to be clean" thing. She's just so saddening I can't bring myself to laugh at all.
A long-term study suggested that metformin continued to improve the metabolic profile of women with PCOS over a 36-month treatment course, particularly improving circulating high-density lipoprotein cholesterol (HDL-C), diastolic blood pressure, and body mass index (BMI).  However, data are insufficient as yet to recommend metformin to all women with PCOS.
Fish oil has been associated with a long list of health benefits, and some research indicates that omega-3 supplements can decrease androgen levels in women with PCOS. One study found that women with PCOS who were given three grams of omega-3s a day for eight weeks had lower testosterone concentrations and were more likely to resume regular menses than subjects who received a placebo.
Myo-Inositol es un compuesto que debe transformarse en el cuerpo en D-Chiro-Inositol. Sin embargo en las mujeres con el Síndrome de Ovario Poliquístico esta transformación no es completa y por eso surge el déficit en D-Chiro-Inositol. El aporte que hace PCOS® de D-Chiro-Inositol compensa ese déficit de los cuerpos que sufren Síndrome de Ovario Poliquístico.
A prospective, observational clinical trial examined the endocrine effects of Tribulus terrestris 750 mg per day, over five days in eight healthy women (aged 28–45). A significant increase in mean serum FSH concentration from 11 mIU/ml before treatment to 17.75 mIU/ml following treatment (P < 0.001) was demonstrated. Pre-treatment FSH levels returned following cessation of treatment (Table 1). Another clinical study evaluated the equivalence of Tribulus terrestris (Tribestan®) and pharmaceuticals for ovulation induction in women with oligo/anovular infertility (n = 148), . During the three month follow up, ovulation rates were highest with epimestrol (74%), followed by Tribulus terrestris (60%), clomiphene (47%) and cyclofenil (24%). However, the evidence for Tribulus terrestris should be interpreted with caution due to risks for bias in clinical studies. One study was uncontrolled with a small number of healthy participants , the second study did not report baseline characteristics, methods for allocation to treatment groups and data were not statistically analysed  (Table 1).
This website is written and published by the research team at Insulite Health, an authority on PCOS for over a decade.The information on the Insulite Health website has not been evaluated by the FDA. Products mentioned are not intended to treat, diagnose, cure or prevent any disease. Individual results may vary. The information and products are not intended as a substitute for the advice or medical care of a qualified health care professional. Insulite Health urges you to seek the advice of your health care professional before undertaking any dietary or lifestyle changes and to share with your provider any information pertaining to your well-being, including the advantages and risks of using of supplemental nutrition products.
Debido a los cambios hormonales, las mujeres con PCOS tienen un mayor riesgo de desarrollar ciertas afecciones de salud serias como la diabetes tipo 2, la hipertensión (presión arterial alta) y trastornos del corazón y los vasos sanguíneos. A menudo, las mujeres con PCOS tienen problemas de fertilidad. Es decir, la capacidad para quedar embarazadas.
Although metformin is not approved by the FDA for treatment of PCOS, many doctors prescribe it for PCOS patients. Metformin is a medicine that makes the body more sensitive to insulin. This can help lower elevated blood glucose levels, insulin levels, and androgen levels. People who use metformin may lose some weight as well. Metformin can improve menstrual patterns, but metformin doesn’t help as much for unwanted excess hair.
Polycystic ovary syndrome is the most common endocrinopathy among reproductive-aged women in the United States, affecting approximately 7% of female patients. Although the pathophysiology of the syndrome is complex and there is no single defect from which it is known to result, it is hypothesized that insulin resistance is a key factor. Metabolic syndrome is twice as common in patients with polycystic ovary syndrome compared with the general population, and patients with polycystic ovary syndrome are four times more likely than the general population to develop type 2 diabetes mellitus. Patient presentation is variable, ranging from asymptomatic to having multiple gynecologic, dermatologic, or metabolic manifestations. Guidelines from the Endocrine Society recommend using the Rotterdam criteria for diagnosis, which mandate the presence of two of the following three findings—hyperandrogenism, ovulatory dysfunction, and polycystic ovaries—plus the exclusion of other diagnoses that could result in hyperandrogenism or ovulatory dysfunction. It is reasonable to delay evaluation for polycystic ovary syndrome in adolescent patients until two years after menarche. For this age group, it is also recommended that all three Rotterdam criteria be met before the diagnosis is made. Patients who have marked virilization or rapid onset of symptoms require immediate evaluation for a potential androgen-secreting tumor. Treatment of polycystic ovary syndrome is individualized based on the patient's presentation and desire for pregnancy. For patients who are overweight, weight loss is recommended. Clomiphene and letrozole are first-line medications for infertility. Metformin is the first-line medication for metabolic manifestations, such as hyperglycemia. Hormonal contraceptives are first-line therapy for irregular menses and dermatologic manifestations.
Insulin-sensitizing agents, including metformin,31 acarbose (Precose),24 and rosiglitazone (Avandia),20 may be used to treat hirsutism in women with PCOS. Spironolactone22 and rosiglitazone32 have been shown to be more effective than metformin, based on Ferriman-Gallwey hirsutism scores. A Cochrane review suggested that metformin is as effective as oral contraceptives for treating hirsutism in women with PCOS,33 but in contrast, a recent systematic review suggested that metformin is not effective.1 Topical eflornithine cream is FDA-approved for management of unwanted facial hair, but there are no published data regarding its use specifically in women with PCOS. Sibutramine (Meridia), which is approved for obesity management, can also improve hirsutism.26
Acne: Birth-control pills, anti-androgen drugs and insulin-sensitizing drugs, all mentioned above, can bring the severe acne of PCOS under control by reducing the high levels of male hormones that trigger bad break-outs in PCOS. In addition, your family doctor or dermatologist may recommend additional acne medications to unclog pores, control skin bacteria and soothe inflammation. These may include retinoids, antibiotics, and products to help unclog pores. One warning: Retinoids can cause birth defects and cannot be used if you are already pregnant or are planning to become pregnant.
PCOS's principal signs and symptoms are related to menstrual disturbances and elevated levels of male hormones (androgens). Menstrual disturbances can include delay of normal menstruation (primary amenorrhea), the presence of fewer than normal menstrual periods (oligomenorrhea), or the absence of menstruation for more than three months (secondary amenorrhea ). Menstrual cycles may not be associated with ovulation (anovulatory cycles) and may result in heavy bleeding.
Hirsutism is treated with a combination of approaches, including oral contraceptives with or without an antiandrogen, such as spironolactone, to lower levels or block actions of androgen on hair follicles. Oral contraceptives are often combined with antiandrogens to improve their clinical effect and to prevent pregnancy, since accidental exposure of the male fetus to antiantrogens can harm fetal development. A topical cream (eflornithine hydrochloride) also can be applied to treat facial hirsutism.
This is a great place for any event: there is a restaurant area for lunches and dinners, small tables for romantic evenings, a lounge area equipped with comfortable sofas and low tables, as well as a huge bar and a dance floor. AQUA LUNA’s summer terrace offers a splendid view onto the yacht club, the spires and roofs of the medieval Old Town, Vanšu Bridge, and modern business buildings – it is the ideal place to enjoy sunshine during the day, sunsets in evenings, and moonlight. In colder weather, AQUA LUNA warms hearts with its cosy atmosphere during long dinners by the fireplace and cheerful weekend parties.
Two important things to note are that the long term safety effects of use are not known (but the drug has been in use for decades already) and spironolactone IS NOT SAFE in pregnancy, so it is commonly used in conjunction with birth control pills. This use of birth control pills also protects against abnormal growth of the lining of the uterus. Some women cannot take birth control pills, in which case it is important to use other means of birth control if you are sexually active while taking spironolactone.
She vain, but she's vain about her aesthetic, not her body. She mentions her imperfections all the time rather than hiding them; she knows she has cellulite, we know that she has cellulite, it isn't something she's trying to hide from the world. Her imperfections are part of her 'poor and free' aesthetic (see gutterpunks for an example of a subculture that glorifies this). The people who point out the problems with her body are adding nothing to the discussion. The comments about her body flaws do nothing but clutter the threads with self-serving, childish garbage, usually in horrible tumblr-speak. Like yeah, we get that Luna's breasts are saggy. We've seen them and heard it a billion times already. Just stop.
Medicamentos sensibilizantes de la insulina. Se usan para tratar la diabetes y es frecuente que también se usen para tratar el PCOS. Ayudan al cuerpo a responder a la insulina. A las mujeres que tienen el PCOS pueden ayudarles a reducir los niveles de andrógenos y mejorar la ovulación. Restablecer la ovulación ayuda a que los periodos menstruales sean más más regulares y predecibles.
Other excluded studies investigated the herbal medicines included in this review examining conditions other than PCOS, oligo/amenorrhoea and hyperandrogenism. These included investigations into effectiveness for Vitex agnus-castus for pre-menstrual syndrome [92–97] and mastalgia [98, 99], Cimicifuga racemosa for menopausal symptoms  and Glycyrrhiza spp with Paeonia lactiflora libido in males .
Something that really strikes me about Luna is that she's completely vacuous. There's nothing going on behind the eyes that isn't related to aesthetic. She barely even seems like a real human being. This was true even before she got hooked on drugs and probably a big factor in why she chose to use. It doesn't seem like she was a bad person prior to heroin (though iirc in http://witchycrankypoo.tumblr.com/ someone mentioned that she was super manipulative and self-focused even before the drugs), but she's certainly always been very, very, very, very shallow.
Janis King graduated cum laude from Florida State University in 2009 with a Bachelor of Science in Nursing and worked as a registered nurse in medical-surgical nursing and critical care. She earned her Doctor of Nursing Practice from Florida State University in 2013 and has since been working in Endocrinology following graduation. Janis is bilingual and fluent in the Spanish language as well.
Dr. Annie Morrissey is Board Certified in endocrinology. She earned her medical degree from Memorial University of Newfoundland. She completed her internal medicine residency at Mayo Clinic in Rochester, MN and her endocrinology fellowship at Washington University in St. Louis, MO. Prior to NCH she practiced in Columbia, TN. She is a member of the American Diabetes Association, Endocrine Society, and American Association of Clinical Endocrinologists
If a regular menstrual cycle is not desired, then therapy for an irregular cycle is not necessarily required. Most experts say that, if a menstrual bleed occurs at least every three months, then the endometrium (womb lining) is being shed sufficiently often to prevent an increased risk of endometrial abnormalities or cancer. If menstruation occurs less often or not at all, some form of progestogen replacement is recommended. An alternative is oral progestogen taken at intervals (e.g., every three months) to induce a predictable menstrual bleeding.[medical citation needed]
Stress exacerbates inflammation. (7) “Put yourself first and make sure your needs are met,” says Medling. You can do this by practicing self-care, which means carrying out small acts that make you feel less stressed and more balanced. This may be via mediation, exercise, or getting in tune with hobbies you love. “Anxiety is one of the key symptoms of PCOS. By reducing stress, you can reduce inflammation and better your hormonal balance,” she says. (8,9)
Though surgery is not commonly performed, the polycystic ovaries can be treated with a laparoscopic procedure called "ovarian drilling" (puncture of 4–10 small follicles with electrocautery, laser, or biopsy needles), which often results in either resumption of spontaneous ovulations or ovulations after adjuvant treatment with clomiphene or FSH. (Ovarian wedge resection is no longer used as much due to complications such as adhesions and the presence of frequently effective medications.) There are, however, concerns about the long-term effects of ovarian drilling on ovarian function.


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Israel eases restrictions on southern residents as ceasefire appears to hold
Though schools remained closed, security officials authorized the return to roads, trains and offices following a ceasefire between Israel and Palestinian Islamic Jihad.
Israeli authorities reopened roads and reinstated train service in southern Israel on Tuesday, as a ceasefire agreement between Israel and Gaza-based terrorist group Palestinian Islamic Jihad seemed to hold following two days of rocket attacks and Israeli reprisals.
Train service between Ashkelon and Sderot stations resumed on Tuesday morning, and the military allowed public travel on roads adjacent to Gaza. Schools remained closed in Ashkelon, Netivot, Sderot and the surrounding regional councils as a precaution, leaving 55,000 children at home.
However, the local councils lifted restrictions on residents requiring that they remain in close proximity to bomb shelters, announcing that they were allowed to fully return to work, including agricultural work starting three miles from the border, and many also lifted restrictions on residents participating in outdoor gatherings.
On Sunday and Monday, more than 100 rockets were fired at Israelis from Gaza by the terror organization, approximately 90 percent of which were aimed at populated areas. Israel’s Iron Dome air-defense system neutralized almost all of the rockets, but a few made it through, causing damage but no injuries.

domain: politics


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After 6 months, the baby can eat solid foods. However, many mothers have a headache with their baby’s weaning. How to train your baby to have the fastest and most delicious eating habits? Let’s explore the 3 hottest baby feeding methods with Phunudaily today.
Traditional weaning method
This is the method many mothers choose for their children. By this method, after 6 months of age, babies can eat solid foods, pureed foods for babies to eat, after one year of age they can eat porridge or cooked rice.
– By this method, mothers do not spend too much time on baby’s meals.
– The fact that the food is pureed, will not affect the baby’s digestive system much.
Quite a lot of mothers do not choose this method, because if they eat a lot of pureed food, the baby’s ability to eat raw will be reduced. Many children up to 2 years old still have to chew and grind food to be able to eat. At the same time, this way is quite unhygienic and makes it difficult for the baby to feel the taste, not eating well.
Japanese method of weaning
This is a method that is quite popular among mothers today. The main features of this method are:
– Separate each type of food: Use a food tray, divide into 3 food groups including starch, protein, and vitamins. Each dish will be set aside for the child to choose.
– Practice giving your baby a light meal, eating a lot of vegetables to meat and fish.
Children eat as much as they want, parents do not force them to eat.
– Do not turn on the TV when the baby eats, just let the baby sit on the chair to focus on eating.
– Feed your baby raw food at the right time: For example, vegetables and meat are processed separately with the right coarseness for babies to eat.
– Children will be able to eat rough faster and earlier.
– Do not cause fear and pressure when the baby is forced to eat.
– Children will eat by themselves, so they will eat more, focus on eating faster.
– Giving your baby the habit of eating bland foods will be good for the baby’s kidneys and digestive system.
– Food is kept separate, the baby will get used to the taste of each food, creating a sense of excitement when eating.
With this method, the mother will spend a lot of time each time feeding the baby. Processing and sorting food will also take longer. Besides, the preservation of food is also a big obstacle.
Self-directed weaning method
The feature of this method is that: Parents decide the food for the baby, but the baby is the one who decides how much to eat.
To form the habit of this method, mothers should gradually practice for their children to go through the following steps:
– Let the child eat with the family.
– Babies can eat the same foods as everyone else, but different in size and appearance.
– Baby chin, grasp food.
– Babies still drink milk in addition to main meals.
– By this method, mothers can let their babies experience their own food, helping them develop their own skills.
Baby can use both hands and eyes to put food into mouth.
– Children learn to bite small food, practice chewing.
– Children can experience interesting dishes with the coarseness and smoothness of different foods.
With this method, the baby’s table will be quite dirty. Mom will spend a lot of time cleaning the baby’s place to eat. In addition, at first, it will be difficult for babies to chew and swallow hard or chewy foods such as meat. Therefore, in the early stages, mothers should monitor their babies to avoid choking or choking.
Here are the 3 hottest baby feeding methods today. Based on the advantages and disadvantages, mothers can choose the method that is right for their baby. I wish you success in your children’s meals!
See also: How to know if your baby is allergic to formula milk?

domain: food


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With his scathing masterpiece Advise and Consent, Otto Preminger indicts the whole Washington political machine with a great sense of subtlety and purpose. It’s one of the only Preminger’s I’ve seen, with maybe the exception of Laura, that doesn’t get bogged down at least for a while in deadly monotonous melodrama, and the end result captivates on a number of different levels.
Advise and Consent begins as a mosaic of the D.C. ecosystem, following Senators of both parties (Charles Laughton, Walter Pidgeon) as they prepare to debate the President’s confirmation of a new Secretary of State (Henry Fonda). Surface-level public procedure swiftly turns into back door wheeling and dealing, illuminating a brutal underbelly of devastating character assassinations, blackmail, and moral ambiguity.
But Preminger never hammers these harsh realities into stone with oratory speeches or grand actions of principle. His brilliant use of the tracking shot allows the narrative to flow along seamlessly behind the characters, one step from realization, yet unable to grasp the ramifications until it’s too late. Even though there’s one heavy in the film, the greatest villain of Advise and Consent remains the compromise of personal identity.
Both Fonda’s left-leaning nominee and Don Murray’s tragic Senator Anderson become victims when the consequences of the past come back to destroy the present. The Capital building acts as a breeding ground for these situations, an elegant bubble blocked from the rest of the world in order to keep the machine running. But the process works, or at least Preminger has faith that it does, and so the gripping finale provides a comeuppance for everyone involved. As a timely precipice on the compromises of Democracy, Advise and Consent will only become more relevant over time.

domain: artistic


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VIVA LASS DIAZ
What Happens In Vegas (12A) Cameron Diaz and Ashton Kutcher spark like fireworks in this highly enjoyable screwball comedy from director Tom Vaughan and writer Dana Fox...
What Happens In Vegas (12A)
Cameron Diaz and Ashton Kutcher spark like fireworks in this highly enjoyable screwball comedy from director Tom Vaughan and writer Dana Fox.
Based on the maxim, "What happens in Vegas, stays in Vegas", a wild night out leads the hapless pair into a sudden crash course in matrimony after drunkenly doing a Britney - and when reality kicks in the morning after, they find themselves challenged to evaluate their lives amongs a decidedly messy fall-out.
City trader Joy McNally (Diaz) and cabinet maker Jack Fuller (Kutcher) end up getting acquainted when they're mistakenly booked into the same room.
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Joy has been dumped and humiliated by her "perfect" banker boyfriend, Mason (Jason Sudeikis), and Jack has been dumped from his job - by his own father.
Feeling like total losers, both have come to cheer themselves up with the obligatory useless and sarcastic best friends in tow, Hater (Rob Corddry) and Tipper (Lake Bell).
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- 4 Stoke Newington eatery voted favourite café by Gazette readers
- 5 Repair Shop's Jay Blades hosts bingo for older Londoners
- 6 Two of the best boozers in Hackney, voted for by readers
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Sticking two fingers up at the world, at first sight none of them can stand each other - until that first evil sip of champagne weaves its dangerous magic.
And suddenly getting married whilst off their faces seems like a brilliant way for Jack and Joy to polish off their evening of unbridled entertainment. After all, they have known each other for a good few hours by then.
Unfortunately it's a glittering event they can barely remember, evidenced only by Joy's tackily ringed finger. And things go from bad to worse when Jack wins $3 million on a fruit machine - with Joy's quarter. The battle of the sexes ensues full throttle as the pair will stop at nothing to defend their right to the money and their right to a divorce.
Laugh out loud funny in places, both leads are thoroughly engaging. It's a piece of dream casting.
Ably supported by Corddry and Bell, there's no amazingly original formula but the dialogue and performances are so fresh and funny that there's little to complain about. No prizes as to the moral of the story but it sure is a lot of fun getting there.
By Susan Hodgetts

domain: entertainment


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A pedestrian was killed during a snowstorm Sunday evening after a pickup truck with an attached plow hit her, according to a dispatch from Alaska State Troopers.
The troopers were notified of a collision between the vehicle and the pedestrian at around 8:30 p.m. The pickup was travelling down Kalifornsky Beach Road near Pirate Lane, when it hit 31-year-old Kenai resident Stephanie Anderson, according to troopers.
Anderson was reportedly walking in the roadway wearing dark clothing during white-out conditions as a result of the storm.
The truck driver, who was not identified in the dispatch, stopped and attempted to render aid, but Anderson was declared dead at the scene, the dispatch said.
Troopers, Kenai Police and Kenai Fire responded to the scene. According to the dispatch, 18 inches of snow were on the ground at that time, in addition to the low visibility.
An investigation into the incident is ongoing.


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Los Angeles-Based Band "The Similar" Releases Debut Single "Pain/Love" from “their” Highly Anticipated Album
(Los Angeles, CA) July 11th, 2023 - "The Similar," an alternative rock band hailing from Los Angeles, is thrilled to announce the release of their debut single, "Pain/Love." The song is the first of ten tracks featured on their upcoming album, set to captivate music enthusiasts worldwide.
"Pain/Love" is a poignant exploration of loss, acknowledging love's profound impact on our lives and the subsequent healing journey. The track delves into the emotions and complexities of navigating through various forms of loss and ultimately accepting the necessity of grieving. With introspective lyrics and a modern take on alternative rock, "The Similar" delivers a powerful and authentic musical experience.
Drawing inspiration from their personal life experiences, "The Similar" has crafted an album that merges their influences and musical backgrounds, resulting in a unique and compelling sound. The band creates an atmospheric backdrop for their introspective lyrics and infectious melodies by combining harmonious guitar arrangements, warm basslines, and rhythmic drums.
Motivated by their shared love for live music and the profound impact it can have on people's lives, "The Similar" embarked on their music career to make a lasting impression. They believe their music can provide solace, healing, and a sense of belonging to listeners of all ages. With their debut album, “The Things I’ve never said” the band aspires to foster a strong community and create a safe space where everyone feels accepted.
The creative process behind the album was a collaborative effort, with "The Similar" coming together to experiment and explore various musical ideas. From jamming sessions in their garage to recording vocals in a friend's living room, the band was determined to create a record they are genuinely proud of. The result is a collection of heartfelt songs that reflect their dedication and artistry.
"The Similar" has planned an exciting release schedule to build anticipation for the upcoming album. Each single will be launched every 30-45 days, accompanied by visually engaging content such as photos, lyric videos, and live performance recordings. This strategy aims to generate buzz and connect with their audience on a deeper level.
The journey begins with the release of "Pain/Love" on Friday, July 7, 2023. The single will be available on various platforms, including Spotify, Amazon Music, SoundCloud, (also put the link to our spotify page in there as well!) and other popular streaming services here at https://ffm.bio/thesimilar.
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Hyattsville Limousine is a trustworthy name in the whole rental world. We assure you a ride with class and style. If you plan for travelling to and from airport, nights on town or just a casual outing, then Hyattsville Limousine and car rental service is the ultimate service to look out for. The Professionally trained drivers will definitely go extra miles to facilitate the customers in the area with the extra luxurious and lavish solution for the customer’s comfort travel. Surely the ride with us is more than an ordinary casual ordinary ride to the city.
Hyattsville is the well recognized place of the prince’s George County, Maryland in the united state. On the way of your journey, we try to meet the all ground transportation needs of the customer. Our chauffeurs are the friendly persons. All the people love to ride in luxury style Hyattsville limousine give the ultimate solution of the accommodation needs.
Hyattsville Limousine is a most desirable and reliable ground based transportation provider in Washington Dc, Virginia and Baltimore as well. We are most preferable limousine service provider as compare to other limo services even from local cab services and trains.
We offer city to city car service and it provides the executive limo service and the representatives of the service are no doubt educated and well known off the streets and roads. When clients hire our limousine car is to be seated with relaxation mood instead of this to guide the drivers the ways they desire to go.
The drivers of the limo cars get rid all the anxieties of the passenger after a stressful travel, his attitude made them convenient and comfortable.
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We are playing very executive role in this field and true source of providing the comfort and stress relief to the clients. If you have to receive your clients from the airport and you need to entertain them with outclass and executive service then you must select us for Airport transportation service to have the best experience in a short time, their well trained chauffeurs will be there for you within no time to receive them. We will not only receive them quickly but take them safely to the desired location as well. More over for your corporate clients they provide you complete comfortable environment, and they have conference and stretch Limos to cater their needs. Our Limos are fully equipped with latest technologies as well.

domain: travel


Nuba is the latest single off African Reality; produced by award-winning music producer, Nase Avatar by AJO whose video has been released today. AJO with no doubt alongside the visual direction of Christopher Kobel (Clumsy Media) have done a tremendous job to push the Afro-centric-agenda.
It is only safe to say AJO is a rap-pan-Africanist who isn’t seeping until we realise we are as important as any race in the world. They say know you past (history) so that you can know where you are going – Nuba offers such information like the previous single, Transcend.
Visually speaking, 2018 has started off with fire videos. Nuba , tells, shows and elucidate visually the state Africa is in and what it should be, what can be celebrated.
Watch Visual Below and tell us what you think:


Millie, a playful standard poodle, picked her paw up off the floor and placed it in the hand of the little girl in front of her. The little girl laughed as Millie chewed on the treat she was given for the trick.
Millie was just one of a handful of dogs spending an hour in Tuten Park’s Education Building on Saturday. The room was also filled with more than two dozen children from the ages of 5 to 12 clamoring over the tail-wagging, face-licking animals.
Also, all of the children were dealing with significant grief from losing a loved one. The dogs they were petting and hugging were therapy dogs, and they were all part of the Shannon Cox Counseling Center’s Good Mourning Gang Winter Group Event.
In the back of the room, photos covered a large portion of one of the walls. Some of the pictures were of smiling adults; others were of babies and small children. The wall was called a “memory wall.” Most of the smiling faces in those photos belonged to deceased relatives of the children in the room. For these kids, Saturday was more than just a day in the park.
Sara McDonald is a counselor with the Shannon Cox Counseling Center. Since 2010, the center has provided counseling, consultation and education to individuals and families in Southwest Louisiana. Recently, the center started offering grief counseling services for children who lost a significant person in their lives.
“This provides support for the children, and it allows them a chance to interact with other kids with similar experiences. Yes, they may go to school or even church with kids their age, but this setting is different. All of the kids here have had some significant loss in their lives,” McDonald said. “Children are always seeking peers, and here we’re providing that in a positive, support-based environment.”
The daylong event is only the second of that type for the center. The previous one occurred over the summer and with its success, McDonald said, there is already a waiting list for the upcoming sessions.
After the children settled down, McDonald had them talk about the photos. Nadia, 14, walked in front of the memory wall and talked about her little sister, Emma. She talked about how Emma died as an infant.
“I would sing ‘You Are My Sunshine’ to her,” Nadia said before she walked back to her seat.
One after the other, kids stood up, walked to the wall of photos and talked about a loved one who was now gone. After each story, the speakers would tap someone else as they headed back to their seat.
Gabriel, 14, talked about his dad, who died in a car accident after leaving his little brother’s karate tournament in New Orleans. Brandon, 9, said his father committed suicide. He went on to talk about the fun things he remembers about him. Bell, 8, said he didn’t really know how his mom died, but he remembers how she used to really enjoy watching “Wheel of Fortune.”
“Everything we do here has a reason behind it. In some way it helps them process their emotions,” McDonald said. “The thing with kids is that they all process their grief differently. They aren’t sad like you and I. For some of them, it may come out in their behavior where they’re acting out or they’re being really withdrawn. Every child is different, and that’s how we treat this process. It’s constantly changing, constantly evolving to fit each individual situation.”
It was a full day for the kids at the park. They participated in a totem pole and mask crafts session. They planted aloe vera plants and they took part in yoga, karate and Zumba dance sessions. McDonald went on to say that determining what to do during the events is a fluid endeavor. The grief concepts are always changing to better suit the needs of the individual.
“All we’re trying to do is develop the best methods for this area. At the end of the day, this whole thing is client directed,” McDonald said.
Outside under the pavilion, balloons floated over one of the tables. The balloons were broken up by color for each of the three age groups at the event — 5-7, 8-9 and 10-12.
Throughout the day, the kids were encouraged to go to the balloons and write something to the loved one they were grieving over. One of the last activities for the kids was to go outside and release the balloon bearing their personal message. Again, McDonald said it was just another creative way to help the kids grieve.
For information about the Shannon Cox Counseling Center’s upcoming events, call 436-9533 or visit the Family & Youth Counseling Agency offices, at 220 Louie St.


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The North Carolina-born rapper also teased the drop of a new album on the cover art for the new EP. “See you soon, Album almost done,” Cordae wrote on Just Until…’s artwork.
Cordae dropped his debut album Lost Boy back on July 26, 2019. It went on to get nominated for Best Rap Album at the 2020 Grammys. The album’s track “Bad Idea” was also nominated for Best Rap Song. Lost Boy featured Chance the Rapper, Anderson .Paak,Ty Dolla Sign, Pusha-T, and Meek Mill.
“I was on the phone with him two days before,” Nahmir told DJ Vlad. “He really didn’t say it to the fullest, but I understood exactly what he was saying. I didn’t expect him to do it, but he did it. And I was like ‘that’s the right choice that you had to make.’ It’s for the right reasons. I can’t get mad at him.”
Stream Just Until…. via Spotify, check out the video for “More Life” above and the video for “Dream in Color” below, and stay tuned for Cordae’s next project.

domain: celebrity


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Tickets for the much-anticipated return of Belgian artist Stromae at the Belgian Werchter Boutique festival in June 2022 have officially gone on sale as of 10:00 AM on Wednesday morning.
The Belgian artist is set to headline the festival on 19 June following a six-year hiatus that saw him step back from the spotlight. He is currently the only artist announced for the one-day festival.
- Rumours circulate of new Stromae album in 2021
- Stromae to feature on Coldplay's new album, new song released
- Stromae makes comeback on Werchter Boutique next year
The Papaoutai singer will also play a second Belgian show at the Les Ardentes festival in Liège on 10 July.
Information on purchasing tickets can be found here.


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The film is an odd retelling of the story of Hercules battling the wizard Minos, who uses "science" in an attempt to take over the world. Hercules must stop him and rescue his princess love in the process. Part of the adventure finds Hercules battling giant robots brought to life by stop motion animation.
Fourteen hundred years ago, a tormented soul walked the earth that was neither man nor god. Hercules was the powerful son of the god king Zeus, for this he received nothing but suffering his entire life.
Based on Frank Miller's latest graphic novel Xerxes and told in the breathtaking visual style of the blockbuster "300," this new chapter of the epic saga takes the action to a fresh battlefield--on the sea--as Greek general Themistokles attempts to unite all of Greece by leading the charge that will change the course of the war.
A decade after his heroic defeat of the monstrous Kraken, Perseus-the demigod son of Zeus-is attempting to live a quieter life as a village fisherman and the sole parent to his 10-year old son, Helius.
In year 1250 B.C. during the late Bronze age, two emerging nations begin to clash. Paris, the Trojan prince, convinces Helen, Queen of Sparta, to leave her husband Menelaus, and sail with him back to Troy.
For years, Blade has fought against the vampires in the cover of the night. But now, after falling into the crosshairs of the FBI, he is forced out into the daylight, where he is driven to join forces with a clan of human vampire hunters he never knew existed - The Nightstalkers.
The Griswold family are on a quest. A quest to a Walley World theme park for a family vacation, but things aren't going to go exactly as planned, especially when Clark Griswold is losing all thought towards a mysterious blonde in a red Ferrari.
High school senior Bobby Chrystal fails his French class, which will block him from entering Yale. His rich, authoritarian father hires an attractive 29-year-old to tutor Bobby over the summer and help him pass a make-up exam.
Kevin Kline and Glenn Close star as Harold and Sarah Cooper, a couple whose marital troubles are put on hold while they host an unhappy reunion of former college pals gathered for the funeral of one of their own, a suicide victim named Alex.
Five friends are released from prison and do their best to stay out trouble. While trying to mind their own business (and run their 5-Star Cleaning Service), they are caught up in a war between rival Triad gangs fighting for control of the counterfeit currency market.
Have you watched Hercules yet? What did you think about it?


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- YEAR OF GRANT
- CATEGORYARTS & CULTURE
- ORGANIZATION LOCATIONLondon, United Kingdom
- GRANT LOCATIONUNITED KINGDOM
This grant supports the new Arts and Homelessness Global Hive and Hubs Network, a collection of regional arts and homelessness organizations across Latin America, Africa, and Asia that will encourage connection and exchange of ideas in the sector.

domain: geography


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Carbon Fiber Gun
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domain: hobby


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Aston Villa Legends
The perfect gift for the Aston Villa Football fan; Aston Villa Legends with heroes from the past and present.
How to Order
1. Pick the artwork size you would like.
2. Add a personal message to your Artwork (Optional).
3. Place your order.
Once the order is received, we will email you a sample for approval before posting your order out.
Aston Villa Football Club
Aston Villa Football Club (also known as Villa, The Villa, The Villans, The Lions) is a professional football club based in Witton, Birmingham, who play in the Premier League, the highest level of English football. Founded in 1874, they have played at their current home ground, Villa Park, since 1897. Aston Villa were the originators and founder members of the Football League in 1888. They were also founding members of the Premier League in 1992, and have remained there ever since.

domain: sports


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This paper presents an innovative approach to detect soft errors in Ternary Content Addressable Memories (TCAMs) based on the use of Bloom Filters. The proposed approach is described in detail and its performance results are presented. The advantages of the proposed method are that no modifications to the TCAM device are required, the checking is done on-line and the approach has low power and area overheads.
|Title of host publication||Proceedings -Design, Automation and Test in Europe, DATE|
|Number of pages||6|
|Publication status||Published - 21 Oct 2013|
|Event||16th Design, Automation and Test in Europe Conference and Exhibition, DATE 2013 - Grenoble, United Kingdom|
Duration: 18 Mar 2013 → 22 Mar 2013
|Conference||16th Design, Automation and Test in Europe Conference and Exhibition, DATE 2013|
|Period||18/03/13 → 22/03/13|

domain: design


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Morning at home, weather warm, quite idle, letter to Richardson,1 evening, a Drawing room, Mr. Randolph’s last speech.2
2. John Randolph made a speech lasting nearly six hours in opposition to a bill to establish a uniform system of bankruptcy throughout the United States (Register of Debates in Congress, 19 Cong., 1 sess., 2:671).
Cite web page as: Founding Families: Digital Editions of the Papers of the Winthrops and the Adamses, ed.C. James Taylor. Boston: Massachusetts Historical Society, 2007.

domain: library


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Alpha-2 Agonist in Combination with Butorphanol and Tiletamine - Zolazepam for the Immobilization of Non-Domestic Hoofstock
A combination of compatible and complementary drugs may constitute the safest and most effective method of immobilization for selected species. Such combinations or “cocktails” have long been used by wildlife veterinarians. These mixtures of drugs consist of a primary drug, usually an opioid or cyclohexamine, with a neuroleptic or α2-agonist added, that can potentiate the primary drug and alleviate its side effects. Additive effects of drugs with complementary modes of action can more selectively induce loss of consciousness, analgesia and muscle relaxation with lower doses of each drug, than if used alone.10
Alpha-2 adrenoceptor agonists (α2-agonist) and their equipotent sedative doses, as a primary drug added to tiletamine, zolazepam and butorphanol is discussed for the immobilization of wild ungulates in a zoo situation. This combination has already been used successfully in ferrets7, wild boars3 and ratites9. The combination of low doses of α2-agonist, butorphanol and zolazepam results in a synergistic CNS depressant response, while minimizing the undesirable side effects of these three types of drugs. Each drug has specific antagonists available for their reversal, thus allowing to reverse one or more of the agonists depending on the desired response. The inclusion of low doses of tiletamine in this protocol affecting different central nervous system receptor populations, seems to aid the synergistic responses of the other drugs with lessened side effects.
Mu-opioid receptors and α2 receptors produce similar effects when activated.12 The interest in the use of α2-agonist is related to their ability to produce sedation, analgesia, muscle relaxation and anxiolysis. All α2-agonists produce decreases in heart rate and cardiac output with an increased incidence of second-degree atrioventicular block, and transient hypertension followed by hypotension. These changes are dose-dependent.12 Xylazine became the first α2-agonist to be used in veterinary medicine; in recent years others like medetomidine, detomidine, romifidine, dexmedetomidine, azepexole, milvazerol and oxymetazoline, have been introduced.12 Binding studies carried out have suggested an α2/α1 selectivity ratio of 1620, 260 and 160 for medetomidine, detomidine and xylazine, respectively. The difference in affinity is suggested to give the difference in doses inducing equipotent sedation and cardiac depression.14
A mixture of 1.2 mg/kg of tiletamine-zolazepam (Zoletil 50®, Virbac or Zelazol®, Fort Dodge), with 0.1 mg/kg of butorphanol (Torbugesic®, Fort Dodge) and an equipotent sedative dose of the α2-agonist, xylazine (Sedazine®, Fort Dodge), medetomidine (Domitor®, Pfizer or 20 mg/ml Wildlife L.) or detomidine (Dormosedan®, Pfizer) was used in 18 different species of ungulates in routine procedures at Africam Safari Park, Puebla-Mexico (Table 1). The criteria for dose selection of the α2-agonist was a comparable sedation, judged subjectively.
Table 1. Equipotent sedative doses of the α2-agonist in combination with tiletamine-zolazepam-butorphanol
Immobilization was characterized by lack of spontaneous movements and lack of response to stimuli. Induction was faster with the xylazine-tiletamine-zolazepam-butorphanol (Xtzb) combination (4–10 min) and slower with the medetomidine-tiletamine-zolazepam-butorphanol (Mtzb) combination (8–18 min). The Xtzb combination appeared to have a shorter duration of effect, as some animals arose suddenly during handling (between 25 and 45 min) without any reversal agent. The detomidine-tiletamine-zolazepam-butorphanol (Dtzb) combination had the longest duration of action.
Reversal was achieved for Xtzb with tolazoline (Tolazine®, Lloyd) (4 mg/kg BW) or atipamezole (Antisedan®, Pfizer) (1 mg/8–10 mg of xylazine1,5) for Mtzb with atipamezole (5 mg/1 mg of medetomidine5), and for Dtzb with atipamezole (3 mg/1 mg of detomidine). Naltrexone (Trexonil®, Wildlife L.) was generally used in all the combinations at 10 mg/mg of butorphanol but in some instances the effect of the butorphanol was left to provide some analgesia. Recovery times were not significantly affected by not providing naltrexone but the animals were not as alert after the recovery. Rapid reversal with atipamezole was completed as expected in all combinations with no recurrent sedation following antagonism. Despite being administered half i.m. and half s.c., atipamezole reversed the effects of Xtzb more rapidly than tolazoline administered all i.v. (1–8 min for atipamezole and 2–15 min for tolazoline). The zolazepam was not reversed.
In cases of early reversal an emergence of the cyclohexamine side effects can be expected. The effects of zolazepam were not reversed and a smooth recovery from anesthesia with no delirium or aberrant behavior was obtained. The pharmacokinetics of tiletamine and zolazepam differ; the effects of zolazepam last longer than tiletamine in some species whereas the reverse is true in others.11 This differential clearance of the two drugs can affect quality of recovery according to species.
During the anesthesia, ketamine was given i.v. (as needed) in increments of 25 mg to produce the effect desired. This produced better depth of anesthesia without interfering with the recovery quality. Using tiletamine-zolazepam as a maintenance agent is not recommended because of the side effects associated with its repeated dosing and the poor quality of recovery.11
In our experience medetomidine, detomidine and xylazine at doses that produce a similar degree of sedation produce approximately the same degree of hypoxemia, as has been previously reported.2 Animals receiving any of the combinations should receive supplemental inspired oxygen when possible. The mean heart rates observed during immobilization were slightly lower than the mean heart rate of immobilizations using potent opioids. The effects of detomidine effects included a significantly lower respiration rate, with more pronounced cardiovascular effects. Xylazine has been reported to produce milder vasoconstriction than medetomidine and detomidine.14
The addition of 0.5 mg of atropine sulfate in the same dart with a xylazine, tiletamine, zolazepam combination has been reported,6 but controversy still exists over the necessity of administering anticholinergics prior to administering α2-agonist,12 especially in wild herbivores. In this study, no premedications were administered in any of the anesthetic procedures.
The Mtzb protocol allowed a remarkably easier endotracheal intubation, presumably attributable to the antitussive property of butorphanol,8 which together with the sedative effect of medetomidine, allowed a clear endotracheal tube placement and acceptance. Other advantages of the addition of butorphanol were the enhancement of sedative and analgesic properties of the α2-agonist, the prolonged duration of the anesthesia, superior muscle relaxation, and the significant decrease in the dose of xylazine, medetomidine and detomidine used, compared to other protocols that use α2-agonist with tiletamine-zolazepam or ketamine.5,6,13
When administered isoflurane (Forane® Abbott), some individuals developed respiratory depression. The butorphanol and the zolazepam decrease the minimum alveolar concentration of inhalation anesthetic4 and therefore, the percent required for the maintenance of anesthesia. When α2-agonists are used with CNS depressants (tranquilizers, opioids, injectable general anesthetics, inhalant anesthetics) significant respiratory depression may occur.12
Species that have been successfully immobilized with these cocktails include the Addax (Addax nasomaculatus), American bison (Bison bison), eland (Taurotragus oryx), scimitar-horned oryx (Oryx dammah), impala (Aepyceros melampus), wildebeest (Connochaetes taurinus), Axis deer (Axis axis), collared peccary (Pecari tajacu), nilgai (Boselaphus tragocamelus), llama (Lama glama), wapiti (Cervus elaphus canadensis), fallow deer (Dama dama), sika deer (Cervus nippon), white-tailed deer (Odocoileus virginianus), and blackbuck antelope (Antilope cervicapra). It is important to mention that the animals used in this work were in general adults with a low excitement level. In the animals where an alarm reaction has begun, higher doses may be required. We observed that the doses recommended in this protocol were not effective in species weighing less than 30 kg, like the brocket deer (Mazama americana), and mouflon sheep (Ovis aries musimom) probably due to their elevated metabolic activity.
When equipotent sedative doses of α2-agonists are administered, they appear to act in a similar manner, with the greatest difference being related to the induction time and the duration of action. There is no anesthetic combination that applies to all situations however and this makes practice challenging, because we are in the continuous process of searching for the ‘ideal’ anesthetic combination.
1. Ancrenaz M. 1994. Use of atipamezole to reverse xylazine tranquilization in captive Arabian oryx (Oryx leucoryx). J. Wild. Dis. 30: 592–595.
2. Celly C, McDonnell W, Young S, Black W. 1997. The comparative hypoxemic effect of four alpha 2 adrenoceptor agonist (xylazine, romifidine, detomidine and medetomidine) in sheep. J. Vet. Pharmacol. Ther. 20; 464–471.
3. Enqvist K, Arnemo J, Lemel J, Truve J. 2000. Medetomidine/tiletamine-zolazepam and medetomidine/butorphanol/tiletamine-zolazepam: a comparison of two anesthetic regiments for surgical implantation of intraperitoneal radio transmitters in free-ranging juvenile European wild boras (Sus scrofa scrofa). Proceeding Am. Ass. Zoo Vet. Pp:261–263.
4. Gross M, Smith J, Tranquilli W. 1993. Cardiorespiratory effects of combined midazolam and butorphanol in isoflurane-anesthetized cats. Vet. Surg. 22;159–162.
5. Jalanka H, Roeken B. 1990. The use of medetomidine, medetomidine-ketamine combinations, and atipamezole in nondomestic mammals: a review. J. Zoo Wild. Med. 21:259–282.
6. Janovky M, Tataruch F, Amvuehl M, Giacometti M. 2000. A Zoletil-Rompun mixture as an alternative to the use of opioids for immobilization of feral red deer. J. Wild. Dis. 36;663–669.
7. Ko J, Nicklin C, Montgomery T, Kuo W. 1998. Comparison of anesthetic and cardio respiratory effects of tiletamine-zolazepam-xylazine and tiletamine-zolazepam-xylazine-butorphanol in ferrets. J. Am. Anim. Hosp. Assoc. 34;164–174.
8. Ko J, Bailey J, Pablo P, Heaton-Jones T. 1996. Comparison of sedative and cardio respiratory effects of medetomidine and medetomidine-butorphanol combination in dogs. Am. J. Vet. Res. 57: 535–540.
9. Lin H, Todhunter P, Powe T, Ruffin D. 1997 Use of xylazine, butorphanol, tiletamine-zolazepam, and isoflurane for induction and maintenance of anesthesia in ratities. J. Am Vet. Med. Assoc. 210: 244–248.
10. Nielsen L. 1996. Chemical immobilization of free-ranging terrestrial mammals. In: Lumb & Jones’. Thurmon J, Tranquilli W, Benson G, eds. Veterinary Anesthesia. Third edition. Williams & Wilkins. Pp.736–764.
11. Pablo L, Bailey. 1999 Etomidate and Telazol. Vet. Clin. North Am. Small Anim. Pract. 29; 785–792.
12. Paddleford R, Harvey R. 1999. Alpha 2 agonist and antagonists. Vet. Clin. North Am Small Anim. Pract. 29; 737–745.
13. Tsuruga H, Suzuki M, Takahashi H, Jinma K, Kaji K., 1999. Immobilization of sika deer with medetomidine and ketamine, and antagonism by atipamezole. J. Wild. Dis. 35;774–778.
14. Yamashita K, Tsubakishita S, Futaoka S, Ueda I, Hamaguchi H, Seno T, Katoh S, Izumisawa Y, Kotani T, Muir W. 2000. Cardiovascular effects of medetomidine, detomidine, and xylazine in horses J. Vet. Med. Sci. 62:1025–1032.


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The new custom map, inspired by the Odyssey line of monitors, debuts this March 23, along with Twitch live streams and scavenger hunt event rewards.
Samsung Electronics announced the launch of Odyssey Universe, a new custom map created for players to experience in Fortnite., based on Samsung’s premium Odyssey series of monitors.
Odyssey Universe is a new in-game experience that expresses how the industry-leading Samsung Odyssey line of monitors helps gamers deliver on the promise of next-generation gaming.
“We are pleased to present the experience gaming Odyssey customization along with fun in one of the most popular games in the world. We will continue to introduce the Odyssey line and increase the awareness of our monitors gaming by providing new and exciting experiences and events,” said Hoon Chung, Executive Vice President of Visual Display Business at Samsung Electronics.
The Odyssey Universe presents each space inspired by the name of the main product of the Odyssey line. The new permanent map is divided into 5 spaces, each one inspired by and representing an entry in the Odyssey line of monitors. It ranges from the Level Ark – which is derived from the “Odyssey Ark” that provides a new frontier of immersion with the 55” large screen – to the Level G9∙G8∙G7∙G6 in line with products like the Odyssey Neo G9 and G8. Each space will have its own mission for players to complete, with a variety of objectives and rewards throughout the game.
Tune in to the debut of the Odyssey Universe on Twitch
Upon launch of Odyssey Universe, players can tune into some of their streamers favorites to see the maps in action on the Samsung Odyssey official Twitch channel:
SypherPK (634.6 million followers)
NickEh30 (435.5 million followers)
Date: March 23 at 1:00 pm local time
The streamers they will showcase the exciting gameplay of the map, inform viewers about how they can explore it, and how to get exclusive offers on Odyssey monitors.
Join the Odyssey Universe Scavenger Hunt
The fun doesn’t end even after the broadcast ends. Through March 29, players have an additional reason to jump into the Odyssey Universe beyond the exciting gameplay of the map. They can participate in the ‘Scavenger Hunt’ event and explore the Odyssey Universe map to find answers hidden in each of the spaces. Once players discover the answers, they can submit them to the Odyssey Universe event website to participate in a raffle. Winners will receive monitors gaming Odyssey and will be announced on the Samsung Odyssey Twitch channel on March 30 at 6:00 p.m.
Players can prepare for the launch of Odyssey Universe by visiting the website to get the latest information, find details about “Scavenger Hunt” and gain access to a special promotion.