text:
Presidents Hugo Chávez of Venezuela and Rafael Correa of Ecuador warned of possible “contagion” in their countries by the autonomy movement in the eastern Bolivian province of Santa Cruz. “The central plan by the CIA and its lackeys in Venezuela is to take control of regional governments to carry out illegal referendums like the one held (Sunday in favor of autonomy) in Santa Cruz, Bolivia. But we will defeat that plan!” said Chávez.
He was referring to regional and local elections to be held in November in 23 states and 335 towns in Venezuela, which according to pollsters could bring advances for the opposition, which only holds two regional governments and a handful of municipalities.
On a map of Venezuela, Chávez pointed to half a dozen states in the west and southwest, along the border with Colombia, which he called Venezuela’s “half-moon”—an allusion to Bolivia’s eastern “half-moon” region, made up of the provinces of Beni, Pando, Santa Cruz and Tarija, where pro-autonomy right-wing political and business sectors opposed to the government of indigenous President Evo Morales hold power.
“Don’t let yourselves be fooled,” Correa said for his part, on his weekly radio program. “What is happening in Bolivia is not an isolated development. It has the support of foreign countries that want to destabilize the region, and of the separatist elites from Guayaquil and Guayas (in Ecuador), and from Zulia in Venezuela.”
Correa pointed out that an International Confederation for Regional Freedom and Autonomy (CONFILAR) was created in 2006 at a conference in the southwestern Ecuadorean city of Guayaquil, which was attended by pro-autonomy leaders from the province of Guayas (of which Guayaquil is the capital), the Venezuelan state of Zulia and the Bolivian province of Santa Cruz, as well as advocates of free enterprise from Guatemala and Peru.
Bolivian Ambassador to Ecuador Javier Zárate said opposition groups are coordinating autonomy referendums in several countries in the region. “We cannot believe or understand how there can be sectors or regions that want dismemberment, separation or disintegration at a time when Latin America and the world are seeking integration,” he said.
But Carlos Romero, a professor of graduate studies in international affairs at Venezuela’s Central University, told IPS that “it is unfair to compare processes like the one Bolivia is experiencing to the situation in Venezuela or Ecuador.”
Bolivia “has faced regional unity problems since it was founded by the independence hero (Simón Bolívar, 1783-1830), while in Venezuela democracy and unity are strong and the opposition respects the rule of law,” said Romero.
The oil and cattle-rich state of Zulia, on Venezuela’s northwestern border with Colombia, was the country’s richest state in the 20th century, and stands out from the rest of the country because of its many distinct cultural expressions.
“We do not want a half-moon; we want a full moon, Venezuela as a whole, in order to take it down the route of progress and development,” stated Zulia’s conservative Governor Manuel Rosales, who lost the 2006 presidential elections to Chávez by 61 to 38 percent.
In Ecuador, Carlos Baquerizo, president of the Civic Council that represents economic and political sectors in Guayas, said with respect to a possible referendum that he does not believe that a new one will be held, “because a decision here was already reached, and it must be respected.”
He was talking about a vote on the matter held in 2000 in Guayaquil, considered a stronghold of the right-wing opposition to the left-leaning Correa.
Last January, thousands of people took to the streets of Guayaquil, Ecuador’s economic capital, to demand that the 2000 referendum be included in the new constitution being drafted by the constituent assembly, in which pro-Correa delegates hold a majority.
“A decision was already reached in favor of regional autonomy in the framework of development accompanied by national unity. What Guayaquil wants has nothing to do with independence” from the rest of the country, said Baquerizo.
In Peru, journalist César Hildebrandt, a columnist with the La Primera newspaper, criticized conservative sectors that support the “break-up” of Bolivia while criticizing talk of federalism in the southern Peruvian province of Puno, on the Bolivian border.
Hildebrandt warned that “the lesson of this dismemberment” is for Chávez to be careful in the case of “his rich Zulia,” for Brazilian President Luiz Inácio Lula da Silva to watch out, in the case of the state of Rio Grande do Sul, whose economic importance is growing and where the population is mainly of European descent, and for Correa to be on the alert with regard to the “rebellious and proudly coastal” Guayas.
Like other presidents in the region, Correa criticized Sunday’s autonomy referendum in Santa Cruz, Bolivia’s richest province, where voters expressed themselves overwhelmingly in favor of greater regional independence.
He referred to the vote as a “separatist attempt” by regional authorities who “represent the interests of economic elites, of whites who have never felt themselves to be part of the Bolivian people.”
He also referred to “international meddling” and foreign financing “of these groups, to create problems for progressive governments, and to bring about the balkanisation of Latin America.”
Chávez, meanwhile, said “there is a strong attempt by the U.S. empire and the Bolivian oligarchy to undermine the state of law and territorial integrity in that country. It is an attempt at Kosovisation (a reference to Kosovo’s declaration of independence) and a blow to all of the peoples of South America.”
The governments of Argentina, Brazil and Colombia, which have acted as a group of “friends” of Bolivia to try to mediate in the crisis since the Santa Cruz referendum, issued a communiqué calling for “a broad, frank dialogue” among the main political actors in Bolivia, “with a view to the preservation of Bolivia’s democratic institutions and territorial integrity” and based on “an open, substantive agenda, without preconditions, and the establishment of a climate of peace, serenity and tolerance.”
At a meeting Monday in Caracas preparatory to the May 23 summit of the Union of South American Nations (UNASUR)—formerly the South American Community of Nations—to take place in the Brazilian capital, the representatives of Bolivia and Venezuela said the new regional integration scheme “will be a cure against divisive and segregationist attempts” in the area.
In Venezuela, the state-run media, as well as the regional public TV network Telesur, provided heavy news coverage of the Santa Cruz referendum, which was portrayed as illegal, unconstitutional and destabilizing.
Chávez’s right-hand man in the United Socialist Party of Venezuela (PSUV), political scientist Alberto Muller, who is a retired general, also said that “in Venezuela there is a plan similar to Bolivia’s.”
Muller said the plan to push for autonomy for several regions, “with U.S. support…is promoted by the Venezuelan opposition, and would be carried out if the opposition won a few regional governments.”
Humberto Márquez for IPS via Upside Down World, May 6


text: It’s been so long it’s like it didn’t exist. I have been motherless for 19 years this December. I am no one’s little girl. I have no one harshly judging me and pushing all the buttons they installed. No one recalls embarrassing things at family gatherings. I miss knowing someone has the secret knowledge of my potty training, first words, school concerts, my failures and accomplishments. I wonder without any hint at what she might say now. Nice people say she would think nice things. I think she would say nice things about me to others but save the judgy harsh bits for weekend phone conversations. Without any parents am I free to be what I want and evolve organically of my own determination liberated from the innate need to please and be pleasing or am I fooling myself that their absence changes anything? Parenthood is powerful and as my teenagers grow I am more concerned I wield my power carelessly finally realizing I will never be an expert . Parenting is a profession of amateurs.

domain: literature


text:
Stablecoin issuer Tether has reportedly changed its terms of service (ToS) in Singapore. An email shared earlier today by the CEO of decentralized finance protocol Cake DeFi shows changes to the company’s Terms of Service that will ban some users from using Tether (USDT).
Cake co-founder and CEO Julian Hosp shared the email he received from Tether. You cannot convert USDT to USD due to changes in your Terms of Service.
Okay, so I can’t tell you if it’s actually possible to convert $USDT to $USD because I’m located in #Singapore and recently @Tether_to’s Terms of Service changed all the time. Interesting.
Okay I know, I can’t tell you if you use the money $USDT into $USD It is actually possible because #SingaporeThis was a recent change. @Tether_to Terms of Service from one day to the next. Interesting. pic.twitter.com/1YzNqkbjMO
—Dr. Julian Hosp (@julianhosp) September 25, 2023
In a post
Major changes to Tether’s Terms of Service include tightening participation standards and “Companies controlled by another entity, directors and shareholders domiciled in Singapore can no longer be considered Tether users.”
The term “controlled by another entity” has confused many in the crypto community, including Cake DeFi, where this is reportedly the case. “it is controlled by another Singapore company. As a result, you will not be allowed to issue or redeem securities on the platform.”
Related: Bank of Singapore imposes 9-year ban on Three Arrows founders
User There was a major cryptocurrency laundering scandal in SingaporeIn cases where seized assets exceed 2 billion dollars.
A month after the massive money laundering bust in Singapore, Tether has restricted users in the city.
Recently crypto companies have moved to Singapore due to more favorable regulations. This could mean a serious blow
Under the pressure of HKG, the gates of Asia are closing in on the cryptocurrency cartel.
1 month after major money laundering bust in Singapore, Tether restricts customers in Singapore
Crypto firms have recently flocked to SG for friendlier registrations. This could be a huge blow
Asia’s doors are closing to the crypto cartel under HKG pressure https://t.co/yVu79bJHgb
— Rho Rider (@RhoRider) September 25, 2023
Another user speculated that changes to USDT payment terms could pose a particular problem for Cake DeFi, stating that the protocol has been marked as EDD (enhanced due diligence) and therefore It may be a matter of partnership between two companies.
This may be an issue specific to @cakedefi. EDD – marked as enhanced DD. I’m not suggesting there’s something wrong with the cake, I just think it could be specific issues with the relationship between the string and the cake.
this could be one @cakedefi particular problem. EDD – marked as enhanced DD. I’m not saying there’s anything wrong with Cake, I’m just saying it might be a specific bond/cake relationship issue.
— Hayden (@hayden_9776) September 25, 2023
Cointelegraph reached out to Tether for comment regarding the email shared by Cake’s CEO and the changes to its terms and conditions of use, but had not received any comments at the time of publication.
Translation by Walter Rizzo

domain: law


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AC's Australian Catalytic Converters
ISSN: 0148-7191, e-ISSN: 2688-3627
Published November 08, 1987 by SAE International in United States
Annotation ability available
The concept: of using catalyst technology to reduce the emissions from automobile exhausts has been around for many years, but it wasn't until 1974 that catalytic converters were first used on production vehicles. Since that first introduction, converters have become a common component on motor vehicles in the United States, Japan and Canada.
On October 27, 1983 engineers representing the five Australian vehicle manufacturers met in Melbourne with AC representatives to review the various catalytic converter designs being considered by manufacturers for use in Australia.
The consensus that day was that all could benefit from a converter with common tooling. Each manufacturer would have unique catalyst coatings tailored to meet individual vehicle requirements but all would use the basic catalytic converter. On that day, October 27, 1983, the design criterion for the basic 1.4 litre Australian Catalytic Converter was determined by Australian and AC Engineers and is currently being used by all five Australian Manufacturers.
Since commencing production just 2 years ago in November 1985, over 450,000 converters have been supplied in two sizes, 1.4 litre and 1.7 litre to the five major Australian Vehicle Manufacturers. Australian catalytic converter exports to Japan and Korea have already exceeded 160,000 units and 300,000 catalytic converter components have been sent to the U.S.A..
CitationSiede, L., "AC's Australian Catalytic Converters," SAE Technical Paper 871266, 1987, https://doi.org/10.4271/871266.
- SIEDE, L.G., Vehicle Technology - Cat. Convs. & Emission Control. October 1981.
- “NEWS” Catalytic Converter Program - June 1983.
- KOMARMY, J.M., (AC Spark Plug Division) KLIMISCB, R.L., (Physical Chemical Dept.) GMR Laboratories, Oct. 21. 1974. Pelleted Catalysts for Automotive Emission.
- TAYLOR, K.C., Automobile Catalytic Converters (GMR-4190, PCP-192). GMR Laboratories, Oct. 8, 1982.
- HOWITT, John S., Monolithic Catalyst Supports Corning Glass Works. Presented at University of NSW Feb. 16-18, 1982.


Bio-mimicry & the ‘Smart’ Indian City
So, India is in ‘development’ mode. With India rooting for ‘Smart’ Cities, (100 Smart Cities Mission) it is critical to analyse the impact of rampant modernization on the future. Instead of looking at short-term benefits, one must understand it holistically and with long-term vision. Across the world, architects and designers and urban planners are using concepts of bio-mimicry – from micro to macro levels, in designing furniture, buildings or entire cities! Whether Vincent Callebaut’s vision for Paris 2050; or Levent Ozler's Langfang Eco-Smart City Master Plan which is said to be a response to the Chicago smart-grid city; or the Nigerian proposal for Abuja City totally based on bio-mimicry – the effort towards green, sustainable and eco-sensitive design is surely picking pace!
This essay by Prashant Dhawan – an architect committed to bio-mimicry in architecture and urban design – highlights the fact that a Smart City risks being disconnected from local ecology and identity if the development is not rooted in the resources and realities of the bioregion. It proposes that a new urban rejuvenation program needs the ‘genius of the place’ to be the central anchor, holding it together and ensuring its balance, integrity and identity.
Read on! We welcome you to post your Comments below the Article!
The ‘100 Smart Cities Mission’ has been launched in India. On one hand India has the benefit of hindsight (from others experience), and on the other hand the problems of environmental degradation, chaotic growth, inequity and poverty confront most Indian cities. It is imperative to ensure that a smart city, truly enhances liveability and is not just another city with a few technological ‘bells and whistles’ thrown in. Like an orchestra without a competent ‘conductor’ a smart city could end up as a cacophony of individually brilliant parts, that might not add up to a coherent whole, with each part trying to be the ‘best’ in reference to external global reference points.
What is Smart? ‘Smart’ is an adjective traditionally used for living things; it’s an attribute found in forms of life and never in the non-living things! It is when our cities or products mimic attributes of life, that we call them ‘smart’. A ‘smart city’ is our aspiration to endow a city with attributes of ‘life’. So to understand how to be ‘smart’, clearly we need to look towards and learn from life/nature.
Cities are complex adaptive systems comprising of diverse, interdependent and interconnected life forms and functions, very similar to a forest eco-system. However, while cities are a relatively recent phenomenon, forests have successfully survived and been around for millions of years having faced the same environmental challenges that a city in the same bioregion would face. The forest eco-system comprises of a huge diversity of life forms wonderfully integrated through interconnected and interdependent networks yet highly decentralised and autonomous with each life form having its own processes and adaptation. These networks are in a state of constant change (with continuous exchange of nutrients and/or information - in ‘flow’ rather than static) and the changes of one part affects and informs change in other part (co-evolves). Forest eco-systems are place-based and run on local resources (intrinsic to the region) that cannot be easily taken away and hence are truly self-sustaining. Networks, flows and co-evolutionary interdependence, are some of the key features of the resilient and sustainable forest eco-system.
The word ‘smart’ translates to ‘Buddhiman’/’Buddhiyukt’ in Hindi. Hence an essential precondition of being smart (or buddhiyukt) is to possess ‘buddhi’. ‘Buddhi’ is the faculty that makes wisdom possible through a holistic understanding of the "creative principle which lies realized in the whole world*”. In context of a city, ‘buddhi’ would mean the integrated understanding of how the local ecosystem functions, the various systems put in place by nature, our ancestors and the successful adaptation strategies of life in this bioregion. Biomimicry defines this knowledge of life support systems and strategies put in place by nature, in the bioregion as ‘genius of place’.
Ancient Indian philosophy also states ‘Vasudhaiva Kutumbakam’, meaning that ‘the world is one family’. It implies that all life is connected and the biosphere is a seamless, interdependent and interconnected system, which has no fixed boundaries or silos. Hence what is a city? A city merely occupies an area defined by administrative control, of an otherwise continuous and undivided biosphere. This implies that the city boundaries need to be viewed more from the purpose of ‘joining’ with the larger network, rather than just separation. Hence to possess ‘buddhi’ (i.e. to be ‘smart’, in context of a city) requires the centrality of the knowledge of the ‘genius of place’ and our thinking requires a ‘shift’ from mechanistic and reductionist to integrated thinking (ecologically inspired - system wide, system thinking).
Clearly, new frameworks which make visible the centrality of ‘genius of place’ and the system of networks, flows and co-evolutionary interdependence among the various functions and parts of the city are required. I propose an alternate ‘visualisation framework’, inspired by the ancient Indian ‘mandala’ form as a step towards shifting of our visualisation of city functions from a mechanistic to a living systems view:
In this smart framework the centrality is of the ‘genius of place’. The framework helps remind us that all elements are anchored to the ‘genius of place’ and connected through networks, flows and co-evolutionary interdependence. This integrated thinking framework, I believe, should help in assisting visualisation that will better ensure the balance and integrity of the system. The 3 key shifts from ‘mechanistic thinking’ to nature inspired ‘ecological thinking’ can be summarised at the three proposed ‘smart mantras'
Network ‘ism’ - all functions and constituents are interconnected and form part of network/s
Flows ‘ism’ - there is constant flow and exchange across all functions and constituents in the system. Nothing is static.
Co-evolution ‘ism’ - all functions and constituents are interdependent, and change at one part/place affects and informs adaptation and evolution in other parts/place.
In this smart framework the centrality is of the ‘genius of the place’. To arrive at smart solutions we need to get out of the mechanistic and reductionist imagination trap, metaphor trap, and process trap of the industrial city. We need to shift from seeing cities as ‘economic arrangements’ to cities as 'part of a continuous, interconnected, complex adaptive ecosystem’. It’s important to begin by understanding the ‘genius of place’ i.e. true and complete working of the place and decrease to the minimum, the degree of incompleteness of our knowledge. That is smart.
Since most decision makers including most planners, architects and engineers are cut off from ecological history, they often get caught up in what is available today and within the site. Hence it is absolutely critical and non-negotiable to have the ‘genius loci’ report available at the pre design stage to serve as the foundation for all decisions. This report should be prepared by the Government (with the help of or through appropriate experts) and should be an essential part of the RfP document or given to the design consultants at the time of award of work.
It is absolutely critical to understand the ‘genius of place’ – the deep knowledge of the eco-system, the terrain on which smart cities will be developed and ensure that our systems are designed in alignment with the intrinsic systems already in place. Any system which is not aligned and is imposed will not be sustainable or will break down or regularly require external investment or constantly require the modification/reshaping of place or user behaviour. The recent floods in Chennai and Mumbai, the pollution of most of our lakes and rivers (including the holy Ganga) are amongst the numerous problems which are consequences and symptoms of development that is misaligned with the ‘genius of place’ of the bioregion. That is not smart!
In this context, we may pay heed to Mahatma Gandhi’s words of caution: “Speed is irrelevant if you are going in the wrong direction.” When we look at the popular media, most of the current ideas/views on smart cities appear to be about 'smart technology’ or ‘smart economy'. Technology and economy are mere tools used to achieve the purpose of creating a smart city. Thus, a 'Smart City planning should ensure that city development is in alignment with the ecology of the bioregion, such that all life thrives! Hence it is very important to ensure and establish that technology and economy are tools or servants to the purpose and not the other way round!
A nature-inspired purpose statement for Smart City development may thus read like this: “A Smart city is one that provides a healthy, nourishing, harmonious, self-maintaining (adaptive and evolving) environment where all life thrives and citizens enjoy sustainable happiness, while enabling each to pursue a way of life and work of choice.”
Smart City Planning with Bio-mimicry: 1. Vision of Paris 2050; 2. Langfang Eco-Smart City; 3. Abuja City, Nigeria + Examples of Bio-mimicry in Architecture featured on TFOD: 4. Jurgen Mayer H's award-winning design of Metropol Parasol in Spain; 5. Javier Senosiain's Nautilus Home; 6. The Blue Panet - Aquarium by 3xn in Copenhagen


text:
US 4696921 A
Mixtures of active substances and pharmaceutical compositions useful in malaria therapy comprising a quinolinemethanol derivative of the formula ##STR1## wherein R1 is hydrogen, fluorine, chlorine, bromine, methyl or trifluoromethyl, R2 is hydrogen, fluorine, chlorine, bromine, methyl or methoxy (at least one of R1 and R2 is other than hydrogen), and R3 is C1-6 -alkylamino-C1-3 -alkyl, di-C1-6 -alkylamino-C1-3 -alkyl, 2-piperidyl or 3-piperidyl, or a pharmaceutically acceptable acid addition salt thereof; a compound which acts as a p-aminobenzoic acid antagonist; and a compound which acts as a dihydrofolic acid reductase inhibitor, are described.
1. An active substance mixture for the treatment or prophylaxis of malaria comprising erythro-α-2-piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol or a pharmaceutically acceptable salt thereof, sulfadoxine and pyrimethamine, in a weight ratio in the range of 10-30:2-20:1.
2. An active substance mixture for the treatment or prophylaxis of malaria comprising erythro-α-2-piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol, sulfadoxine and pyrimethamine in a respective weight ratio of about 10:20:1.
3. An active substance mixture for the treatment or prophylaxis of malaria comprising hydrochloride addition salt of erythro-α-2-piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol, sulfadoxine and pyrimethamine in a respective weight ratio of about 30:2:1.
4. A pharmaceutical composition for treatment or prophylaxis of malaria comprising an effective amount of erythro-α-2-piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol, sulfadoxine and pyrimethamine in a respective weight ratio of about 10:20:1 and a pharmaceutically acceptable carrier material.
5. A pharmaceutical composition for the treatment or prophylaxis of malaria comprising an effective amount of hydrochloride addition salt of erythro-α-2-piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol, sulfadoxine and pyrimethamine in a respective weight ratio of about 30:2:1 and a pharmaceutically acceptable carrier material.
This is a continuation-in-part of Ser. No. 331,360, filed Dec. 16, 1981, now abandoned, which is in turn a continuation of Ser. No. 122,645,filed Feb. 19, 1980, now abandoned, which is a continuation of Ser. No. 904,958, filed May 11, 1978, now abandoned.
The invention relates to mixtures of active substances including pharmaceutical compositions for the treatment of malaria comprising a quinolinemethanol of the formula ##STR2## wherein R1 is hydrogen, fluorine, chlorine, bromine, methyl or trifluoromethyl, R2 is hydrogen, fluorine, chlorine, bromine, methyl or methoxy, provided that at least one of R1 and R2 is other than hydrogen, and R3 is C1-6 -alkylamino-C1-3 -alkyl, di-C1-6 -alkylamino-C1-3 -alkyl, 2-piperidyl or 3-piperidyl, or a pharmaceutically acceptable acid addition salt thereof; a compound which is a p-aminobenzoic acid antagonist; and a compound which is a dihydrofolic acid reductase inhibitor. The pharmaceutical compositions comprise, in addition to a quinolinemethanol derivative, a p-aminobenzoic acid anatagonist, and a dihyrofolic acid reductase inhibitor, a pharmaceutical carrier therefor.
The simultaneous use of several active substances or ingredients having an antibacterial spectrum of activity in the treatment of bacterial infections has been known for a long time and has led to favorable results, for example, in the fight against tuberculosis. Further, it is possible in many cases to prevent or to severely inhibit the development of strains of causative organisms which are resistant to specific active substances. Investigations are turning to an increasing extent to the development of combination preparations. The combination of sulfonamides with dihydrofolic acid reductase inhibitors to give fixed combinations such as, for example, sulfamethoxazole with trimethoprim to give cotrimoxazole, permits the effective control of the causative organisms of bacterial infections, which organisms are already largely resistant not only to sulfonamides but also to antibiotics alone. With the combination sulfadoxine/pyrimethamine there has been developed an antimalarial agent, whose action depends on the mutual potentiation of the two components, and which is also effective against strains of causative organisms which are resistant to antimalarial agents such as chloroquine [7-chloro-4-(4-diethylamino-1-methylbutylamino)-quinoline] and other derivatives of 4-aminoquinolines or to pyrimethamine. The risk of the formation of resistance has now been reduced, by the present invention as hereinafter discussed, to an extent which has not hitherto been achieved with the aforementioned sulfadoxine/pyrimethamine combination.
Recently, mefloquine [erythro-α-2-piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol], a compound from the quinolinemethanol series, has been shown to be very suitable for the treatment of malaria, especially of tropical malaria. Furthermore, this compound exhibits good activity against chloroquine-resistant strains of Plasmodium falciparum. It is, however, to be feared that with the wide use of this compound, as well as of structurally analogous compounds from the quinolinemethanol series, there will also result relatively rapidly a resistance to these compounds, which would have a very negative effect on the future control of malaria in the world.
Since 1974 the situation worldwide in the field of malaria control has deteriorated, notwithstanding the intensive efforts of the WHO (World Health Organization). Malaria has increasingly spread in the majority of the countries, particularly in South East Asia and Latin America, so that, the number of chloroquine-resistant strains of the causative organism of tropical malaria, that is, Plasmodium falciparum, has increased to alarming proportions. The situation is made worse by the resistance of the transmitting mosquitoes to insecticides, for example, to DDT, which is already evident to some extent. Thus, the chloroquine-resistant Plasmodium falciparum strains further increase. Accordingly, there is an urgent objective in the fight against malaria to reduce the number of chloroquine-resistant causative organisms and to prevent their furtheer spread, namely, by means of medicaments which do not give rise to the development of resistance or contribute to a minimal development of resistance. By the development of combinations, which contain an quinolinemethanol derivative of formula I hereinafter which is active against malaria and a compound which acts as a p-aminobenzoic acid antagonist as well as a compound which acts as a dihydrofolic acid reductase inhibitor, the objective is approached to a considerable extent.
By way of background, it is noted that a preferred active substance mixture of the present invention, namely, mefloquine (base), sulfadoxine, and pyrimethamine (10:20:1 by weight) was published in the Bulletin of the World Health Organization 61(2) 169-178 (1983).
Also by way of background, it is noted that oral disclosure of a preferred active substance mixture of the present invention, namely, mefloquine (base), sulfadoxine, and pyrimethamine (10:20:1 by weight) was made at the Fifth International Congress of Parasitology in Toronto (Canada) Aug. 7-14, 1982.
The present invention provides active substance mixtures which consist of a quinolinemethanol derivative of the formula ##STR3## wherein R1 is hydrogen, fluorine, chlorine, bromine, methyl or trifluoromethyl and R2 is hydrogen, fluorine, chlorine, bromine, methyl or methoxy, provided that at least one of R1 and R2 is other than hydrogen, and R3 is C1-6 -alkylamino-C1-3 -alkyl, di-C1-6 -alkylamino-C1-3 -alkyl, 2-piperidyl or 3-piperidyl, or a pharmaceutically acceptable acid addition salt of such a quinolinemethanol derivative; and a compound which acts as a p-aminobenzoic acid antagonist; as well as a compound which acts as a dihydrofolic acid reductase inhibitor. The invention also comprises pharmaceutical compositions based on said active substance mixtures and pharmaceutical carriers therefor.
The aforementioned p-aminobenzoic acid antagonist is preferably a sulfonamide or a sulfone, preferably sulfadoxine (4-sulfanilamido-5,6-dimethoxypyrimidine), sulfadimethoxine (6-sulfanilamido-2,4-dimethoxypyrimidine), 6-methoxy-4-sulfanilamidopyrimidine, sulfadiazine (2-sulfanilamidopyrimidine), sulfalene (2-sulfanilamido-3-methoxy-pyrazine), dapsone [bis(4aminophenyl)-sulfone], acedapsone [bis(4-acetamidophenyl)-sulfone] or bis(4-formamidophenyl)-sulfone; sulfadoxine is especially preferred.
The aforementioned dihydrofolic acid reductase inhibitor is preferably proguanil, also known as N1 -(p-chlorophenyl)-N5 -isopropyldiguanide or, especially, pyrimethamine, also known as 6-ethyl-2,4-diamino-5-(p-chlorophenyl)-pyrimidine.
Chlorine is preferred among the halogen atoms referred to earlier in connection with the definition of R1 and R2 in formula I. R1 and R2 in formula I are preferably situated in the 6-, 7- and/or 8-position. Preferred C1-6 -alkylamino-C1-3 -alkyl groups are 2-(C2-4 -alkylamino)-ethyl, especially 2-(tert. butylamino)-ethyl; and preferred di-C1-6 -alkylamino-C1-3 -alkyl groups are 2-(di-C2-4 -alkylamino)-ethyl, especially, 2-(dibutylamino)-ethyl. The 2-piperidyl group is the preferred piperidyl group.
The quinolinemethanol derivatives of formula I are known. To prepare the acid addition salts of the quinolinemethanol derivatives of formula I, especially of salts which can be used in pharmaceutical preparations, that is, physiologically compatible salts, there come into consideration inorganic and organic acids which are customarily used for this purpose, for example, hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, oxalic acid, tartaric acid, maleic acid, benzoic acid, succinic acid, fumaric acid, levulinic acid, salicyclic acid, citric acid, isocitric acid, adipic acid, lactic acid, α-ketoglutaric acid, malic acid, malonic acid, glyceric acid, mevalonic acid, glucuronic acid, neuraminic acid, glutaric acid, aspartic acid, gluconic acid, mandelic acid, ascorbic acid, lactobionic acid, glucoheptonic acid, glutamic acid, nicotinic acid, pantothenic acid, folic acid, adenylic acid, geranylic acid, cytidylic acid and inosic acid.
Mefloquine and its acid addition salts, especially the hydrochloride, is especially preferred as the quinolinemethanol component. A combination of mefloquine, optionally in the form of an acid addition salt, preferably as the hydrochloride/sulfadoxine/pyrimethamine is the preferred active substance mixture provided by the present invention.
On the basis of the aforementioned active substance mixture, that is mefloquine hydrochloride/sulfadoxine/pyrimethamine, there is demonstrated hereinafter the improvement which can be achieved in malaria therapy with the active substance mixtures provided by the present invention and which results in the reduced development of resistance.
It will be appreciated from the discussion which follows that two preferred active substance mixtures of the present invention are mefloquine/sulfadoxine/pyrimethamine (10:20:1 by weight) and mefloquine hydrochloride/sulfadoxine/pyrimethamine (30:2:1 by weight).
A. The active substance mixture mefloquine hydrochloride/sulfadoxine/pyrimethamine (30:2:1by weight) was subjected to a test for the experimental development of resistant malaria strains in mice.
Albino mice (weighing 20 g.) were infected intravenously on day +0 with the N-strain of Plasmodium berghei (Keyberg 173) (injection dosage approximately 107 parasitized erythrocytes) and treated on five successive days with the aforementioned active substance mixture. The first treatment was carried out 2-3 hours after the infection. On day +7 the infection was transmitted to new mice, which were treated in the same manner. The substance amount was thereby increased. This technique was used for all runs which follow. The donor mouse for the succeeding run must achieve on day +7 at least an erythrocyte infection rate (EIR) of approximately 10%. The mice were kept at an environmental temperature of 20±2° C. and received a standard mice diet and drinking water ad libitum. The active substance solution was freshly prepared each week, in most cases dissolved in an 0.5% aqueous carboxymethyl-cellulose solution or occasionally in distilled water, with addition of one drop of a polyoxyethylene-sorbitan fatty acid ester, and each mouse was given per os 0.2 ml. per treatment. The parasite infection was established on day +7 with the aid of Giemsa-colored blood smears.
The active substance mixture was tested for 36 weeks according to the method described earlier.
Table: Dosages of active substance mixture in mg/kg. (5×p.o.) tolerated by the N-strain of Plasmodium berghei, increase in the resistance after 24 or 36 runs.
______________________________________ At theActive substance beginning of After Aftermixture the experiment 24 runs 36 runs______________________________________Mefloquine hydro- 2 + 0.13 + 0.07 5 + 0.37 + 5.7 + 0.5 +chloride/ 0.18 0.25sulfadoxine/pyrimethamine(30:2:1)______________________________________
As is evident from the foregoing Table, the resistance to the active substance mixture investigated can increase. This increase is, however, comparatively small. After about 17 runs, an almost constant value was achieved and this hardly rose thereafter. The rapid achievement of a plateau, which was not foreseeable, establishes the great therapeutic advance obtainable with the active substance mixture mefloquine hydrochloride/sulfadoxine/pyrimethamine (30:2:1) provided by the present invention.
The active substance mixture of mefloquine, sulfadoxine and pyrimethamine (10:20:1 by weight) was subjected to tests for the experimental development of resistant malaria strains in mice.
The ability of the active substance mixture of the invention mefloquine, sulfadoxine, pyrimethamine (10:20:1 by weight) to inhibit the development of drug resistance by the rodent malaria parasite P. yoellii nigeriensis was compared to that of:
4-Sulfanilamido-5,6-dimethoxypyrimidine (Sulfadoxine); and
A 20:1 mixture (by weight) of Sulfadoxine and 6-ethyl-2,4-diamino-5-(p-chlorophenyl)-pyrimidine (Pyrimethamine).
The methodology employed and results obtained when the active substances were tested for their ability to inhibit the development of drug resistance are as follows:
Albino mice, strain Fullinsdorf SPF were fed on a diet of NAFAG 850 (containing a relatively high and variable PABA-content, 45-100 mg/kg) and tap water ad libitum. These mice were injected (i.p.) on D+O (=day of infection) with approximately 107 parasitized erythrocytes containing Plasmodium yoelii nigeriensis strain. The animals were administered either Active substance of the prior art or Active substance of the invention beginning on D+2 for 3 consecutive days. Blood films were made on D+7. On the same day blood was taken from a donor mouse of one of the treated groups showing a reasonable parasitemia, (i.e., 2-10% erythrocyte infection rate [EIR]. The dosage which yielded this EIR at each passage is plotted in the following figure as maximum tolerated dose [mtD]. The donor mouse blood was injected into a new group of mice. Drug dosage was gradually increased during successive passages.
It can be seen from the figure that drug resistance of the parasite, as reflected by the mtD, developed much more slowly when the subjects were administered the active substance of the invention, i.e. a combination of Mefloquine, sulfadoxine and pyrimethamine, than it did when the subjects were administered any of the active substances alone, i.e. Mefloquine, sulfadoxine or the potentiating combination of sulfadoxine and pyrimethamine.
The active substance mixtures provided by the present invention can be used as pharmaceutical preparations having direct or delayed liberation of the active ingredients in association with a compatible pharmaceutical carrier. Such carrier can be an organic or inorganic inert carrier material suitable for oral administration such as, for example, water, gelatin, gum arabic, lactose, starch, magnesium stearate, talc, vegetable oils, polyalkyleneglycols, or the like. The pharmaceutical preparations can be made up in a solid or liquid form, for example, as tablets, dragees, capsules, solutions or syrups. The pharmaceutical preparations may be sterilized and/or may contain further adjuvants such as preserving, stabilizing, wetting or emulsifying agents, flavor-improving agents, salts for varying the osmotic pressure or buffer substances. The pharmaceutical preparations can be prepared in a known manner.
The weight ratio of the individual components to one another in the active substance mixtures or the pharmaceutical compositions provided by this invention can vary within wide limits. It can be in the range of from 50:1 to 1:1, preferably between 20:1 and 2:1, for p-aminobenzoic acid antagonist to dihydrofolic acid reductase inhibitor, while the ratio of quinolinemethanol derivative of formula I to p-aminobenzoic acid antagonist plus dihydrofolic acid reductase inhibitor can be in the range of from 10:1 to 1:10, preferably between 10:1 and 1:3.A preferred weight ratio in the case of sulfadoxine to pyrimethamine is 20:1, the dosage unit for this case is 0.1-25 mg/kg., preferably 1-7 mg/kg. A preferred dosage unit for mefloquine hydrochloride in the mixture is in the range of from 1 to 15 mg/kg.
The active substance mixtures provided by the present invention as well as the pharmaceutical preparations based thereon are suitable not only for the curative treatment of all forms of malaria with an individual dosage in the form of, for example, one or more tablets, depending on the body weight of the warm-blood mammal and directions of the practitioner, but also for the prophylaxis and suppressive therapy in the sense of the WHO terminology at intervals of 1-4 weeks.
The following Examples illustrate pharmaceutical preparations containing the active substance mixtures provided by the present invention.
______________________________________Example 1Tablets containing:______________________________________Sulfadoxine 500 mg.Pyrimethamine 25 mg.Mefloquine (base) 250 mg.Maize starch 100 mg.Lactose 100 mg.Cellulose 200 mg.Polyvinylpyrrolidine 130 mg.Colloidal silicon dioxide 6 mg.Talc 24 mg.Magnesium stearate 12 mg. 1347 mg.______________________________________
______________________________________Example 2Tablets containing:______________________________________Sulfadoxine 300.0 mg.Pyrimethamine 15.0 mg.Mefloquine hydrochloride 109.65 mg.Maize starch 50.0 mg.Lactose 50.0 mg.Cellulose 99.35 mg.Polyvinylpyrrolidone 65.0 mg.Colloidal silicon dioxide 3.0 mg.Talc 12.0 mg.Magnesium stearate 6.0 mg. 710.00 mg.______________________________________
______________________________________Example 3Tablets containing:______________________________________Sulfadoxine 100.0 mg.Pyrimethamine 5.0 mg.Mefloquine hydrochloride 36.5 mg.Maize starch 16.5 mg.Lactose 16.5 mg.Cellulose 33.0 mg.Polyvinylpyrrolidone 21.5 mg.Colloidal silicon dioxide 1.0 mg.Talc 4.0 mg.Magnesium stearate 2.0 mg. 236.0 mg.______________________________________

domain: biology


text:
The Flash star Tom Cavanagh opened up about being asked to direct the season finale of Superman and Lois on The CW.
As Superman and Lois continues to explore the Man of Steel in ways we haven’t really seen in live-action before, The Flash star Tom Cavanagh has confirmed that he’ll direct the season finale of the latest series in the Arrowverse. It was recently confirmed that Cavanagh will soon leave the Scarlet Speedster’s show along with Carlos Valdes’ Cisco Ramon, but the Harrison Wells/Nash Wells actor isn’t done with the TV universe just yet.
Tom Cavanagh has directed episodes of The Flash in the past, including the show’s 100th episode, so clearly he’s excited about the shift in his career. When discussing the news with Entertainment Weekly, Cavanagh explained that he was incredibly grateful to be invited onboard to direct Superman and Lois. Take a look below.
“They asked me to direct their finale. As you know, I directed the 100th episode of Flash and I embraced the pomp and circumstance of these types of episodes, and I’m really grateful to be jumping on board Superman & Lois. And let’s talk about that for a second. It’s a funny thing to say, like, ‘Wait… Superman!’ I love the fact that’s a Warner Bros. property that’s getting yet another go-around. I love the fact that they’re getting to the emotional and familial heart of it. I’m just really looking forward to directing their finale. That doesn’t start for a couple weeks when we [head into] prep. I’m just so grateful for the invitation.”
Are you excited to see what The Flash star Tom Cavanagh brings to the Superman and Lois finale? How do you think the story will pan out? Sound-off in the comments below!
Here is the synopsis for the last episode, “The Best of Smallville”:
As Smallville celebrates its first Harvest Festival since Martha’s passing, Clark is reminded what his mother meant to him and learns a lesson that will help him move past her death. Meanwhile, Lois makes a breakthrough in the investigation of Morgan Edge. Lastly, Kyle tries to reconnect with Lana, but it seems like he might be falling back into his old ways.
In addition to Tyler Hoechlin as Clark Kent and Elizabeth Tulloch as Lois Lane, the series stars Jordan Elsass and Alexander Garfin as the sons of the titular characters, Dylan Walsh as General Sam Lane, Emmanuelle Chriqui as Lana Lang, and Erik Valdez as Kyle Cushing. Written by The Flash‘s Todd Helbing, the series will be executive produced by Helbing, Greg Berlanti, Sarah Schechter, and Geoff Johns.
Superman and Lois returns Tuesday, May 18 on The CW. Stay tuned for all the latest news on The Flash, Tom Cavanagh and the rest of the Arrowverse, and be sure to subscribe to Heroic Hollywood’s YouTube channel for more original video content in the future!

domain: entertainment


If you still use Nox player 6.2.X.X, then you can try the Nox player 184.108.40.206 update. This is something more advanced than version 6.2.X.X. As we know with the frequent update of the Nox player, users get the opportunity to freely upgrade the version. So it is time to download Nox player 220.127.116.11 using the app download link that we attached here.
Downloading Nox player is just a simple process. It is entirely free and you can enjoy many more benefits here. Because of this wonderful emulator, PC users get the opportunity to download mobile apps, games to the PC. Then you can play games on PC using the keyboard, mouse, and speakers with a better view.
Nox player 18.104.22.168 for Windows | MAC
Yes, this wonderful download Nox player 22.214.171.124 emulator supports both windows and mac operating system versions. For Windows users, it supports Windows XP SP3, Windows Vista, Windows 7, Windows 8, and Windows 10 devices. For Mac users, you can use it with Mac Sierra 10.12 and Mac Sierra 10.11.
The Nox player 126.96.36.199 supports a Dual-Core Processor, GL 2.0 or above, RAM of 2GB, or support nearly 2 GB storage.
If you have completed those related facilities, then hurry up and download Nox player 188.8.131.52 to your PC, and enjoy plenty of these options without any messing.


Digital Transformation Can't Happen Without Organizational Change
Service providers need to rethink organizational structures and internal processes before starting their digital transformation.
Digital transformation is a hot topic for most businesses today, but what does it really mean for network operators? It’s a worthwhile question, especially as some analysts try to make the term sound old-fashioned.
Is digital transformation a matter of offering digital services, cultivating digital sales channels, automating customer care processes and virtualizing their networks? Yes, but there is more to it than that. We think it means reworking a company from within in order to create more valuable services and make internal processes more efficient.
That’s the distinction. It’s not about how much or how little virtualization is involved and it’s not necessarily about how many copper landlines are still connected. Digital transformation starts with looking closely at organizational and operational processes. It doesn’t take long to see that traditional telecom business structures are not fit for the digital world. In the past, service providers had separate departments for network operations, IT and customer care. But evolving technologies are blurring the lines between business functions, which means structural divisions must be removed.
Service providers can break down these barriers by organizing teams of people that cut across marketing, sales, customer care, networks and IT. Focused teams with skillsets from across the organization can react quickly to the market by offering newer and more relevant services and understanding the customer better. This will give service providers greater visibility into customer interactions at every point—from when customers subscribe to a new service to when they pay their bills each month.
Management must be able to use data from across the entire organization to understand what their customers want and the quality of their experiences. With insights from across the company, service providers can offer more personalized services and support.
But this holistic view is not possible when business processes are siloed; structures and processes must also change if companies want to create new services. Rather than having separate development and operations processes, for example, service providers should adopt a DevOps approach, enabling services to be launched more quickly—potentially in days instead of months.
Of course, the prospect of virtualizing network and IT infrastructures is one of the biggest drivers for revamping internal processes and rethinking how services are developed. Although there has always been a clear distinction between IT and network operations, the continued shift to move everything to software in virtualized environments has caused the lines between IT and networks to fade.
From an operational perspective, network virtualization has a huge impact. Service providers need to change how they deploy, manage and assure services on new, virtualized networks. This is going to be a major challenge for providers because they’ll have to completely change their traditional assumptions about how they run their companies.
Gradually, a new kind of digital service provider will replace the traditional telecommunications provider. But without a change in the service provider’s business, the technologies and network improvements that can enable this transformation won’t make a difference.


text:
GROBLERSDAL – Residents in the Groblersdal Police Station’s neighbourhood fear for their safety after rubble composing building material, including corrugated iron sheets and poles, remain unresolved within the station’s yard.
The residents complained that the unresolved rubble lay at the station for months and had potential to attract dangerous reptiles for refuge.
The unsorted material lay at the station for more than three months after the red-ants delivered them there when they evicted more than 700 families from a privately owned property of Sekhukhune TVET College outside Groblersdal.
Neighbours who are directly affected by the unattended rubble are elderly people who are housed at the Herfsakker Old Age Home which is separated from the station by fence.
The elderly at Herfsakker told the paper they have since the rubble’s existence, experienced problems of snakes and mice which they haven’t had before.
“They must do something about the rubble. Our lives are now being exposed to danger because of it. It must be removed from here. The other problem is that if it can catch fire it will burn our home,” said one of the elderly.
A client who also did not want her name published in the paper said: “The concerns of the residents are valid. Accumulation of rubble could be dangerous in whichever way imaginable. The matter should be urgently addressed. This is one of the places at which we should feel safe from any kind of danger.”
Captain Manong Tshehla, Groblersdal Cluster Police Spokesperson, referred all queries to the sheriff of the court.
Tshehla said the belongings were merely at the station for safe keeping after their owners were evicted from Aquaville.
“We have no control on the matter in terms of when and how they will be removed from the station as they are only here for safety reasons. That lies solely with the sheriff of the court,” said Tshehla.

domain: sociology


text:
After the past few years of generating buzz, Villano Antillano released her debut album La Sustancia X on Friday (December 2). The rising Puerto Rican star teamed up with iLe and La Dame Blanche on the LP where she celebrates women and the LGBTQ+ community.
Antillano has emerged as a powerful voice for women and the queer community as a trans woman in reggaeton and Latin trap. She scored one of the biggest hits of the year “BZRP Music Sessions #51” alongside Argentine producer Bizarrap. Their knockout collaboration has over 155 million views on YouTube. Back in July, Bad Bunny gave the rapper a co-sign when she appeared as a special guest at his concerts in Puerto Rico. In La Sustancia X, she becomes harnesses the power of her being and cuts loose with her fierce flow.
“‘La Sustancia X’ is the sonic story of a woman who held back her power for a long time and finally, shows her flame to the world,” Villano said in a press release. “It is a deep journey into the innermost spaces of being, where we find the good, the bad and the powerful. Villana is sharp, calibrated, feminine and dominant.”
Villano embodies that empowering message throughout the 11-track album. In the sassy reggaeton banger “Cáscara de Coco,” she pays homage to queer pioneer La Delfi while giving her props to women with with tough skin. Villano blends hip-hop beats with influences of house music in the hot-and-heavy “Hedonismo” where she sings about living her best life.
Puerto Rican singer iLe joins Villano in the Latin trap anthem “Mujer.” Backed by an alternative rock influence, both artists trade verses about being women in charge and not backing down. Villano joins forces with Cuban singer La Dame Blanche in the electrifying “Puesta” where they assert their femme dominance. With the dreamy “Poli,” Villano shows versatility to her artistry with a beautiful Afrobeats influence.
La Sustancia X is out now via Sony Music Entertainment. Listen to it here.

domain: celebrity


text:
Mech Cadet Yu returns this week with its first issue since being promoted to an ongoing series.
As the world deals with the aftermath of the invasion, Yu and his team face punishment and…his mom?
Writer Greg Pek obviously had a mission in mind when he was writing this issue. He wanted to show how there was more story to tell with these characters now with the series now ongoing. The usual methods are put into place: more world building, consequences to the first arc, and additional characters are introduced to help showcase there is more to explore in the world of Mech Cadet Yu.
An interesting aspect which is introduced is the clean up crew. More media involving giant monsters needs to focus on the aftermath from the initial attacks. In this moment it’s made painfully obvious these are the Cadets and robots which were not meant for combat duty. The animosity towards Yu and his team who are there as part of disciplinary action make it clear they don’t take too kindly for their presence. All of which is handled in a very subtle way.
The artwork by Takeshi Miyazawi helps to capture the new expansion to the series. The rough and obviously not ready for the field look of the clean up robots helps to illuminate their lower quality construction. Also, the Chief’s mech shows there are far more design possibilities for the robots in this series than originally thought.
The color work Triona Farrell is up to the usual quality but doesn’t have as much a chance to shine as in previous issues. This is due to the lack of explosions or effects which make her draw attention. No deterioration in quality though.
The lettering by Simon Bowland offers some great emphasis on the dialogue. The sound effects also help to add the extra bit of charm to the book.
Mech Cadet Yu is still a lot of fun and this new issue feels like there is going to be a lot of excitement coming in the future. Don’t let this now ongoing comic pass you by.


text:
At Popisms.com, we show you how pop culture (TV, movies, books, ads) is connected to other pop culture. For example, what song is in that Super Bowl commercial
or TV episode? What book is that character reading? What music is another song sampling? We answer these questions and many more
I've Got Your Number by Jack Jones
I've Got Your Number (Song)
TV/Films that reference I've Got Your Number
This song is played in:
December 25, 2013
This song plays while Sydney and Irving work together, scamming people.


text:
I am a PhD Candidate at Centre for Fertility and Health, a Centre of Excellence (SFF) founded by The Norwegian Research Council. I work in the project "Lost in Transition? Uncovering social and health consequences of sub-optimal transitions in the education system" examining the long-term health consequences of sub-optimal transitions in education.
Kathryn Beck has a background in nursing and a Master's degree in public health from the Norwegian University of Science and Technology (NTNU), with a specialization in Global Health. She has also worked as a research assistant focusing on educational inequalities in health and interventions targeting child health inequalities.
Projects and publications
- Kathryn Christine Beck, Mirza Balaj, Lorena Donadello, Talal Mohammad, Hanne Dahl Vonen, Claire Degail, Kristoffer Eikemo, Anna Giouleka, Indrit Gradeci, Cèline Lossius Westby, Kam Sripada, Magnus Rom Jensen, Solvor Solhaug, Emmanuela Gakidou, Terje Andreas Eikemo, (2022). Educational inequalities in adult mortality: a systematic review and meta-analysis of the Asia Pacific region. BMJ Open doi: 10.1136/bmjopen-2021-059042
- Kathryn Christine Beck, (2022). A Propensity Score Analysis of High Stakes Exam Failure and Mental Health.
- Kathryn Christine Beck, (2022). The Effect of High-Stakes Exam Failure on Mental Health.
Mobile: +47 950 52 151
Myrens verksted 2, 0473 Oslo

domain: medical


text:
Video: These fans react to Bruno Fernandes’ ‘shameless’ ‘dive’ for Man United vs Sevilla
Some football fans were furious after Bruno Fernandes appeared to dive in a bid to win a penalty during Manchester United’s Europa...
August 16, 2020 22:53
Manchester United FC
Chelsea battle Tottenham in transfer scrap for £22m-rated Brazilian ace to bolster midfield
Chelsea and Tottenham have reportedly both joined the race to sign Spartak Moscow midfielder Fernando who is seemingly a man in demand...
May 1, 2018 12:06
Watch: Liverpool concede fantastic 27-yard free kick as Reds go behind early on in Champions League tie
Liverpool conceded a fantastic 27-yard free kick from Spartak Moscow’s Fernando as the Reds went behind in their Champions League clash against...
September 26, 2017 20:19
Private: Manchester City eye-up 29-year-old Barcelona star to bolster squad, club interested in activating £152M release clause
Barcelona stalwart Sergio Busquets is reportedly a target for Premier League side Manchester City this summer, with City boss Pep Guardiola having...
August 9, 2017 9:56
Champions League: Real Madrid ELIMINATE Man City, will face Atletico Madrid in Champions League Final
Real Madrid are advancing to the UEFA Champions League Final after knocking off Manchester City in the Champions League Semi-Finals. The Citizens...
May 4, 2016 21:38
Man City international attempts to explain horror gaffe against PSG in Champions League draw
Manchester City goalkeeper Joe Hart has refused to be too downhearted by the glaring defensive error that led to Paris Saint-Germain‘s opener....
April 7, 2016 11:51
Video: Terrible goal kick between Hart and Fernando lets PSG equalize against Man City
Give Zlatan an inch and he’ll take a mile – that’s a lesson Fernando failed to remember in what should have been...
April 6, 2016 21:34
Fernando goal video: Manchester City midfielder trolled by own club after sweet volley v Bournemouth
Things were so good for Manchester City during the opening 20 minutes against Bournemouth this afternoon that even Fernando managed to get...
April 2, 2016 15:58
Liverpool v Man City predicted lineups: Three changes apiece as Reds seek Capital One Cup revenge
Liverpool and Manchester City lock horns again at Anfield tonight, just three days after Manuel Pellegrini’s men pipped the Reds to the...
March 2, 2016 12:08
Capital One Cup final predicted XIs: Man City’s goalkeeping gamble, Liverpool make one crucial change
Liverpool and Manchester City will battle it out for the first major trophy of the season when they meet in the Capital...
February 28, 2016 7:01
Chelsea 5-1 Man City report & video highlights: Men vs. boys as Hazard & Fabregas run riot against kids
Chelsea comfortably dispatched of Manchester City’s kids to reach the quarter-finals of the FA Cup courtesy of a 5-1 victory at Stamford...
February 21, 2016 19:10
Manchester City player ratings vs West Ham United: Aguero heroic as defenders struggle early
Although Manchester City were able to avoid losing their second straight match to West Ham United, the one point they gained from...
January 23, 2016 20:49
West Ham FC
Football News 24/7
Empire of the Kop
The Boy Hotspur
The Celtic Star
Juve FC News
Latest Featured News
(Video) Chaos at Etihad as Dallas fires Leeds United ahead minutes before Cooper sees red for shocking tackle
Leeds United have taken a shock lead against soon-to-be title winners Manchester City in Saturday’s early Premier League kick-off. READ MORE: Newcastle United...
April 10, 2021 13:27
Leeds United FC
Harry Kane set to request move away from Tottenham Hotspur
April 10, 2021 9:04
Despite public reservations, digital Covid passports will be quickest route to fans back inside stadiums in large numbers
April 9, 2021 11:22
“It would be silly to turn it down” – Solskjaer urged to make exception to Man United transfer policy for this one player
April 7, 2021 14:54
Erling Haaland or Kylian Mbappe? Liverpool, Chelsea and PSG bloggers give us their perspective
April 6, 2021 14:04
Arsenal legend names the five signings Gunners need and calls for Arteta to return star to his best position
April 6, 2021 8:25

domain: news


text:
Back in the U.S.
More in Television
A daily updated summary of the week in TV.
A documentary chronicling Paul McCartney on stage and behind the scenes as he travels across the United States while on tour. The film features performances ranging from the Beatles and Wings through his vast solo career and peaks into previously unseen parts of McCartney's life on the road.
What's On Tonight
MOST POPULAR - ARTS
- Critic’s Notebook: ‘Serial’ Podcast Finale: A Desire for ‘Eureka’ as the Digging Ends
- Stephen Colbert by the Numbers
- Darlene Love’s Last ‘Letterman’ Christmas
- ArtsBeat: Cuba: A Reading List
- Art Review: Killing and Nurturing, All Surprising
- Virna Lisi, Actress Who Rose in ’60s, Dies at 78
- Irene Dalis, Opera Singer and Company Founder, Dies at 89
- Classical Critics Pick the Top Music Recordings of 2014
- Critic’s Notebook: Oldest Testaments: A Close-Up View
- The TV Watch: ‘Stephen Colbert’ Says Goodbye as Stephen Colbert Heads to CBS

domain: artistic


text:
Hardstyle, Rawstyle and Frenchcore to start the year in the best possible way.
After several editions of "Freaqshow" and "Wow Wow", Q-dance will premiere this year the indoor festival epiq. This new event will be held on December 31 from 20:00 to 07:00 within the great Ziggo Dome, Amsterdam (NL) and you will be able to listen to different styles such as Hardstyle, Rawstyle y french core.
El anthem of this new festival has been created by Devin Wild, Rebelion and LXCPR, giving a melodic rawstyle hymn to this new Q-dance project. And it is that the line-up of this festival is integrated in its vast majority by artists from Hardstyle y Rawstyle.
LINE-UP EPIQ 2020 - Hardstyle: D-block & S-te-Fan, Demi Kanon, Devin Wild, Primeshock, Psyko Punkz, Sound Rush and Frequencerz, - Raw style: Act of Rage, Rebelion and D-Sturb. - Frenchcore: Sefa.
On the other hand, during the night you can enjoy several versus in which there will be a mix of Hardstyle y Rawstyle or Rawstyle and frenchore like: D-Block & S-te-Fan vs. D-Sturb, Act of Rage vs. Sefa, Psyko Punkz vs. Frequencerz, Sound Rush vs. Demi Kanon,
If you still do not have the tickets on December 19, Q-dance gives the opportunity to buy special tickets that include access to a pre-party, drinks and a meet & greet with the different artists. On the other hand, the dresscode of the party will be the neon, so if you plan to go, go preparing your most striking and phosphorite clothes, apart from different paintings for your faces.
You can find tickets and more information on how to get there you can find it through the official page.


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The Transfusion Medicine Department of NITOR has the following tasks:
- Asst. Prof. Dr. Khairul Islam
- Abdul Hamid
- Md. Hasem
- Syed Md. Khalid
Tasks: We do the Blood Grouping (ABO & Rh Type) of the patients coming to NITOR. Then we do the grouping, selection of the Donor and collection of the blood from the donor. Ultimately we supply the blood to the donor after the screening process of the donor’s blood is done.
Cross matching is done between patients blood. Screening of the blood includes:
- HBs Ag


text:
Why do I need Retreatment?
With the appropriate care, your teeth that have had endodontic treatment will last as long as other natural teeth. Yet, a tooth that has received treatment may fail to heal or pain may continue to exist. Sometimes, the pain may occur months or years after treatment. If so, Endodontic Retreatment may be needed.
Improper healing may be caused by:
- Curved or narrow canals that were not treated during the initial treatment.
- Complicated canals that went undetected during the initial treatment.
- The crown or restoration was not placed within the appropriate amount of time following the procedure.
- The crown or restoration that did not prevent saliva from contaminating the inside of the tooth.
What will happen during retreatment?
First, the endodontist will discuss your treatment options. If you and your endodontist choose retreatment, the endodontist will reopen your tooth to gain access to the root canal filling material. In many cases, complex restorative materials crown, post and core materials must be disassembled and removed to permit access to the root canals.
After removing the canal filling, the endodontist can clean the canals and carefully examine the inside of your tooth using magnification and illumination, searching for any additional canals or unusual anatomy that requires treatment. After cleaning the canals, the endodontist will fill and seal the canals and place a temporary filling in the tooth. If the canals are unusually narrow or blocked, your endodontist may recommend endodontic surgery.
After your endodontist completes retreatment, you will need to return to your dentist as soon as possible to have a new crown or other restoration placed on the tooth to protect and restore it to its full function. Is retreatment the best choice for me?
Is retreatment the best choice for me?
Whenever possible, it is best to save your natural tooth. Retreated teeth can function well for years, even for a lifetime. Advances in technology are constantly changing the way root canal treatment is performed, so your endodontist may use new techniques that were not available when you had your first procedure. Your endodontist may be able to resolve your problem with retreatment. As with any dental or medical procedure, there are no guarantees. Your endodontist will discuss your options and the chances of success before beginning retreatment.
What are the alternatives to retreatment?
If nonsurgical retreatment is not an option, then endodontic surgery should be considered. This surgery involves making an incision to allow access to the tip of the root. Endodontic surgery may also be recommended in conjunction with retreatment or as an alternative. Your endodontist will discuss your options and recommend appropriate treatment.


By Mark Perriman
Western Magpie forward Jordan Bain’s dominant effort in front of goal against Sandgate has earned him the Round 11 Syd Guildford Trophy nomination.
Bain’s deadeye 11-goal performance caps off a recent purple patch for the Redland-listed player.
Whilst Magpies coach Glen Humphries acknowledges a solid team performance and good service was key in the team’s 99-point win, he points to Bain as the dominant forward on the field.
“The fact is he took the game by the scruff of the neck,” Humphries said.
“And he had an Aspley centre-half playing on him for part of the game as well.”
Hard work seems to be paying dividends, whose earlier difficulties in front of goal look to be a thing of the past.
Humphries notes that the former state U18 representative looks to have improved his goal kicking, a sentiment shared by his player.
“I’ve really been working on my kicking in front of goal, practicing my set shots,” Bain said
“Trying to be consistent, and do what the team needs me to do. It seems to have paid off.”
Intent on pushing a return to the seniors, eleven goals seems to have registered with Redland, promptly recalling him for this weekend’s away game.
“I just got called up last night, so I’m playing in Darwin on the weekend,” said Bain.
With his coach confident in his chances of taking out the award, a return to the NEAFL this weekend would likely also come as no surprise to his coach.
“He is a very dynamic forward,” noted Humphries.
“On his day, he is as dominant as any going around.”


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Council will also hear from Koulla Yiasouma, the Commissioner for Children and Young People, on the need for proper age appropriate, inclusive relationship and sexual education.
Recent research has shown the North is the most dangerous place in Europe for women, with more domestic violence killings here per capita than anywhere else.
Speaking about the meeting Cllr O’Neill said: ‘We’ve gone from a pandemic into a cost of living crisis.
“Both these crises have deepened the structural inequalities women experience on an everyday basis.
“In addressing gender based violence we must look at the structural violence of the state impacting women such as Universal Credit, the two-child benefit cap, the costs of childcare and the denial of reproductive rights.
“Research has shown when we have a recession, when poverty deepens, we see an increase in domestic violence.
“This is not to excuse men but to highlight that we must properly address poverty and deprivation in dealing with gender based violence.
“Services and shelters that support women and children experiencing domestic violence must also be invested in.
“And we must educate individuals on consent, sexual harassment and victim blaming to dismantle the belief that women and girls are responsible for their own safety.
“Education is key to challenging the roots of violence against women but we also need deep-rooted structural change.
“The impact of the cost of living crisis will disproportionately impact women, including potentially leading to increased domestic violence.
“This isn’t acceptable. We need action on the cost of living crisis and on all fronts to protect women and girls in our communities.’
The Council meeting will take place at 4pm today and can be accessed online.Tags:

domain: politics


Floral Print Skinny Pants
Must-have alert! We are in love with these incredibly cute skinny pants. They have a chic abstract floral print on a stretchy woven body, faux front pockets, an outline zip fly closure for a super sleek fit, and back patch pockets. Pants have a pull-on construction and an elasticized waistband.
Model is 5’9" and wears a size S/M.
- 29" Inseam
- 10” Leg Opening
- 70% Cotton / 25% Nylon / 5% Spandex
- Machine Wash


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Lifetime Dental Specializes in Tooth Extractions in Lake Forest
Sometimes a patient is recommended a tooth be extracted due to various reasons. While a tooth extraction may sound complicated, it is actually a very routine procedure that, according to the Mayo Clinic, carries a very low risk of long-term complications. We understand that any dental procedure can be scary, but at Lifetime Dental, we assure the procedure itself is painless and will be performed by an experienced dentist or oral surgeon, with a simple recovery process.
Why Would I Need a Tooth Extraction?
There are several reasons a patient would need a tooth extraction, such as if a tooth has been broken or damaged by decay. A tooth would also need to be extracted if it is very loose and cannot be saved. Other reasons a tooth would need to be extracted include:
- If the tooth has become a source of infection.
- If wisdom teeth are decayed, cause pain or have an infection, a wisdom tooth extraction will be needed. These teeth are normally extracted because they can’t come in properly, causing irritation to the gum, pain, and swelling.
- If braces are needed, but there isn’t enough room for the teeth to be moved into place.
- If there are extra teeth that block the others from coming in.
The Tooth Extraction Procedure
Generally, tooth extractions are uneventful procedures that only take a few minutes to perform. The dentist will first take an X-ray of the area to plan the best way to remove the tooth. If a patient needs to get their wisdom teeth removed, a panoramic X-ray may be taken to see all of the teeth at once in order for the dentist to plan the procedure.
The tooth, gum, and bone will then be anesthetized using a local numbing agent for a patient who will be awake for extraction. Nitrous oxide, or laughing gas, may also be administered to help with any anxiety during the procedure. During the extraction procedure, patients should feel only pressure – not pain. In most cases, the dentist can remove the tooth simply by loosening the tooth with a tool called an elevator, and then uses an instrument called a forceps to remove the tooth, rather than removing it surgically.
If a tooth has been broken off at the gum line, a surgical extraction may need to be performed. In the case of a surgical extraction, the dentist or oral surgeon makes a small incision into the gum in order to extract the tooth.
Recovering After a Tooth Extraction Procedure
Following your dental extraction, the dentist or oral surgeon will provide you with a specific set of instructions for caring for the extraction site for the next few days. Usually, this involves leaving gauze on the extraction site to minimize bleeding for the first few hours.
The dentist or oral surgeon may prescribe you with medication to help relieve pain for the first few days following the procedure, depending on the type of tooth extraction performed. As long as the extraction site is kept clean and patients follow the instructions given to them by the dentist, the gums should heal in a matter of weeks without complications. Once the extraction site heals, a bridge, denture or permanent dental implant can be used to replace missing teeth if necessary.
Starting the Tooth Extraction Procedure
While the tooth extraction procedure is simple, it is still a surgery and we understand you may have questions or concerns. At Lifetime Dental in Lake Forest, CA, we want to provide our patients with services that are customized just for them. We have a multi-specialty dental practice that offers a full range of dental services including tooth extraction, cosmetic, general and preventive dentistry. Our experienced staff is here to help our patients achieve the results they’re looking for.
If you have wisdom teeth that are bothering you, or a different tooth that may need to be removed, please get in touch with us. Our skilled dentists are here to help you choose the best option for you and go over any questions you may have regarding the procedure. Call us today at 949-581-8109 to schedule your appointment.


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Item no. 461010474548
Make an all-new addition to your Pop! collection with this Jannah vinyl figure! Created by Funko, Jannah wears her classic costume from Star Wars: The Rise of Skywalker.
Magic in the details...
- Inspired by Star Wars: The Rise of Skywalker
- Moulded details
- Head mounted on spring gives 'bobble' movement
- Created by Funko
The bare necessities
- Figure: H9cm approx.
- Packaging: H16 x W11.5 x D9cm approx.
- Made from vinyl
- Warning: not suitable under 36 months due to small parts

domain: hobby


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Amy Steinberg with special guest Ash Ruiz: A Night of Music and Mayhem
Amy Steinberg is an uplifting, soulful performer that raises the roof with her joyful noise. Nationally touring for over 20 years, Amy has created several powerful collections of music and played her own brand of comedic pop all over. There's a spiritual energy about her work, but she believes in marrying the sacred and the profane to express the powerful divinity of this marvelous life through her work.”
Come enjoy an evening of live music, food and drinks at the Isis Music Hall. Reservations are highly recommended.
Main Hall Concert Seated - Limited Tables Available with a Dinner Reservation :: Please Call Venue for Dinner Reservations and Tickets 828-575-2737


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SUPREME COURT OF NEW YORK, APPELLATE DIVISION, SECOND DEPARTMENT
July 15, 1968
LEO A. WEISS, APPELLANT,
EDWARD NATHAN, RESPONDENT
Appeal from order of the Supreme Court, Nassau County, dated October 3, 1967, which, on defendant's motion, dismissed the complaint, dismissed, without costs. The order was superseded by the later order on reargument ( Alpert v. Alpert, 20 A.D.2d 560). Order of the same court dated November 30, 1967, which, on reargument, adhered to the original decision, affirmed insofar as appealed from, without costs.
Christ, Acting P. J., Brennan, Hopkins and Munder, JJ., concur; Martuscello, J., concurs.
In our opinion, the only reasonable inference that may be drawn from all the facts is that respondent was authorized to speak on behalf of the corporation Avien, Inc., and the Chairman of its Board of Directors, Pierre Alsina, personally. Indeed, appellant's attorney virtually admitted as much when he stated in his affirmation on the motion for reargument, "It is true that when the Court originally considered this motion evidence was wanting to refute defendant's contention, contained in his reply affidavit, that he had been authorized to make 'these specific statements' by Pierre Alsina." To supply the lack, appellant relied upon an affidavit by Alsina to the effect that no express authority had been given to respondent to go beyond the discussion of pure legal questions. In our opinion, however, this bare claim is so palpably untrue as to raise no triable issue. Nowhere is it stated that Alsina or any of the directors of the corporation objected to or withdrew any of the allegedly unauthorized statements, even though the speech in question was made in their presence, at a stockholders' meeting, and they had ample opportunity to do so. Furthermore, it is undisputed that in a petition that he verified on May 9, 1966, a few days after the meeting, Alsina repeatedly stated, with respect to the charges of misconduct leveled against appellant by respondent, that he (Alsina) had caused the charges to be announced to the stockholders. In the circumstances, appellant has made no evidentiary showing in opposition to respondent's motion that is sufficient to raise a triable issue (see Schillinger v. North Hills Realty Corp., 15 A.D.2d 539
, affd. 11 N.Y.2d 1044).
Martuscello, J., concurs in the dismissal of the appeal from the order dated October 3, 1967, but otherwise dissents and votes to reverse the order dated November 30, 1967 insofar as appealed from and to deny defendant's motion to dismiss the complaint, with the following memorandum:
At a stockholders' meeting of Avien, Inc., on May 6, 1966, defendant expressed an opinion which is the subject of this action. Later what he said was put in written form by Pierre Alsina, Chairman of the Board of Directors of Avien, Inc., and given to defendant, who was outside counsel for the corporation at the time, for publication in the form of a "news release." On September 16, 1966, in an attempt to settle the various differences which had arisen among them, plaintiff gave Alsina and Avien, Inc., a general release. On February 16, 1967, plaintiff brought a prior action against defendant, for libel, alleging that the news release, written by Alsina, which defendant had delivered to the newspapers, was defamatory. On June 13, 1967, that action was dismissed on motion, on the ground that the general release by plaintiff of one joint tort-feasor, Alsina, released defendant, absent an express reservation to the contrary. The court found that the alleged libel was the joint product of Alsina, as author, and defendant as distributor or publisher. On June 14, 1967, the day after the dismissal, appellant commenced this suit for slander, predicated on the alleged defamatory remarks spoken by defendant to those present at the stockholders' meeting on May 6, 1966. On June 30, 1967, respondent moved under CPLR 3211 (subd. [a]) for dismissal of the complaint, and under CPLR 3211 (subd. [c]) for judgment on the merits, claiming (1) the action was barred under the doctrine of res judicata and the rule of collateral estoppel, (2) the releases executed by appellant to Avien and Alsina constituted a bar to the action, (3) the statements complained of were privileged and (4) the complaint fails to state a cause of action because the alleged statements are not defamatory per se and there is no allegation of special damages. In opposition, appellant submitted an affidavit by Alsina to the effect that he had not authorized respondent to make the statements in question, either on behalf of Alsina or of Avien, wherefore neither Alsina nor Avien was a joint tort-feasor with respondent in the alleged slander and the releases in favor of Avien and Alsina did not operate to release respondent. The motion was granted, the court holding that the dismissal of the libel action, on the basis of the prior release to Alsina and Avien, was res judicata as to this slander action. On reargument the court adhered to its original decision. It seems to me that the determination of the libel action is not necessarily res judicata as to the slander action. In the libel action, Alsina prepared the libelous writing and defendant distributed it. They were therefore jointly and severally liable. Release of Alsina would release defendant for the libel. In the instant case, however, the complaint alleges that defendant was the author of the slander. Furthermore, Alsina deposed that he had not authorized defendant to make the statements, on behalf of either himself or the corporation. Although defendant was counsel to the corporation at the time of the statements, there is no proof as to whether in making such statements he acted as an agent of the corporation or as an independent contractor. Therefore, as to whether Alsina or Avien would be chargeable with uttering the slanderous statement presents a question of fact. If neither Alsina nor Avien can be chargeable with the slander, then the release to them had no effect on the action predicated thereon and consequently the libel determination would not be conclusive at bar. For these reasons a trial is necessary to ascertain whether Avien and Alsina were joint tort-feasors with respect to the slander. If no such situation exists, then defendant cannot utilize the release and the defense of res judicata.
© 1998 VersusLaw Inc.


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domain: finance


text:
"Achieving peace in the region has never been so close," said Zacharie Gross, Ambassador of France to Azerbaijan, APA reports.
"The French and the Germans have fought for many years. In the last 150 years, there have been 3 wars between two countries, and millions of people have lost their lives from both sides. Newspapers, magazines from both countries have carried out propaganda for long years and introduced the opposite side as an enemy. Propaganda has been carried out in our schools, hateful nationalism has been promoted. But today both countries are friends, are close to their history, proud of their history and culture. After that, the war between our countries is unbelievable, our countries have made peace, we have cleared our territories of mines, and our cooperation in various fields has developed. We have deep daily relations in the border areas. Most importantly, we have jointly created the European Union.
I consider that this experience is also interesting for Azerbaijan and the South Caucasus.
I wish you to be from a generation that established peace in your region and achieved peace between Azerbaijan and Armenia. It is true the peace is not fully ensured, this road is complicated, there are traps on this road, but achieving peace in the region has never been so close," said Zacharie Gross.


text:
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Jordan Jackson of Stockdale High School signs his letter of intent April 16 to attend school and play tennis for the University of Mary Hardin-Baylor in Belton. He is joined by (from left) his father and coach, Lester; his mother, Ginger; and Stockdale Athletic Director Josh West.
STOCKDALE -- After years of dedication and hard work, another goal was reached for Stockdale senior Jordan Jackson, as he signed on to attend school and play tennis for the University of Mary Hardin-Baylor in Belton. . . .
The full article is available to Wilson County News subscribers only (if you receive the paper in the mail or if you have purchased an E-subscription). Subscribe today or purchase this issue (May 1, 2013) for $3.00. (If you are already a subscriber, simply login using the boxes to the left.)


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The CBI has registered a case in the alleged irregularities during the construction of a high-end mall in Indore, including the role of the then Madhya Pradesh chief minister, Digvijaya Singh.
The FIR was registered on the orders of Indore Bench of the Madhya Pradesh High Court which had directed it to probe the “roles of senior officials, the then CM, chief secretary, and environment minister”, among others.
According to the CBI, the case pertains to allegations that the mall was illegally built on a residential plot of one lakh sq ft, with undue concessions from the then state government under Singh. In its order on October 19, Division Bench of Justices P K Jaisawal and Moolchand Garg directed the CBI to probe into the matter and report in six months.
The Bench gave the direction on a plea by social activist Mahesh Garg who had filed a complaint with the state Economic Offences Wing (EOW) in 2009 which had given a clean-chit to Singh.
Soon after the court order, Singh had welcomed the probe and posted on Twitter that “permission was given for it (mall) during my tenure as chief minister. The BJP government’s Economic Offences Wing has already investigated the matter and found nothing against me”.
The EOW had filed FIR against Entertainment World Developers Pvt Ltd, which constructed ‘Treasure Island’ mall in a joint venture with Madhya Pradesh Housing Board in 2002, and probed the role of 12 accused officials and ministers, including Singh. It filed a closure report giving a clean chit to Singh, saying that there was a case against six others, including the developer. After the closure report, Garg filed a PIL in the HC which has now given the case to the CBI.


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Zortrax Inkspire is a resin desktop 3D printer working in UV LCD technology. It’s designed around a high-resolution LCD screen* with UV LED backlighting that ensures every part of a layer is exposed to the same amount of UV light to uniformly cure the resin. A single pixel measures just 50×50 microns while minimal layer hight is only 25 microns. That’s why the smallest details Zortrax Inkspire can 3D print are invisible to the naked eye. This means it offers quality of prints surpassing leading SLA 3D printers while working up to 8x faster. Zortrax Inkspire is perfect for engineering, short and medium series manufacturing as well as precision modeling in dental prosthetics or jewelry design. The printer works with dedicated Zortrax Resins. Third-party resins are also supported, provided they can be cured by light with 405 nm wavelength.
More on: Zortrax
“It’s not the size of the printer, it’s what you can put through it. High throughput: you’ve either got it or you don’t.” Dentaform’s got it in spades. It prints more dental models per hour than any other printer in its category—we’re talking up to 10 every 30 minutes. That’s enough to handle an entire aligner treatment plan over lunch.
|Platform Size||200 x 150 x 100 mm||7.8 x 5.9 x 3.9 in|
|Footprint||480 x 470 x 480 mm||1.6 x 1.5 x 2.7 ft|
|Weight||80 kg||176 lbs|
|Printing Accuracy||50 microns|
|Z-direction Layer Thickness||50 microns|

domain: design


‘Downs Don’t Need Lorch, Chiefs Do’
After Thembinkosi Lorch has been linked with a transfer to Mamelodi Sundowns, it has been claimed Masandawana don’t need him but Kaizer Chiefs do.
The DStv Premiership winners are looking to strengthen their team for next season, with Slovakian striker Pavol Safranko already confirmed as new signing.
‘Nyoso’ is one of the players rumoured to interest Sundowns but former midfielder Charles Motlohi believes that the 2019 Premier League Footballer of the Season is not the right fight for Masandawana.
“No, I don’t think they need him. Thembinkosi Lorch and Oupa Manyisa play the same style of football,” Motlohi told KickOff.
“And I also count the age – if he was 16 or 17-years-old, I would recommend he be signed, but the problem is when you bring someone in who is only coming for pension.
“Lorch is good but not for Sundowns. I think a move to (Kaizer) Chiefs might suit him better because, honestly speaking, Chiefs don’t have players at the moment.
“Just imagine how many players are playing in his position at Sundowns in the current squad – the likes of (Hlompho) Kekana can’t even get game time.
“I trusted (Kermit) Erasmus to do well at Sundowns but he is forever injured. But as for Lorch, no, I don’t rate him that much to play for us.”
Lorch has missed large parts of 2020/21 due to a tear in the abductor muscle and has scored just one goal for Pirates in the Premiership so far.
The 27-year-old, though, will be keen to help his side defend third spot on the log when they face TTM on Saturday.
- / 2 hours ago
Kaizer Chiefs coach Stuart Baxter has given an update on which Amakhosi players will...
- / 2 hours ago
AmaZulu coach Benni McCarthy has revealed how Mamelodi Sundowns have helped his side to...


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Create and enjoy less time in the kitchen and more time with your family and friends with CURLY’S BBQ that was cooked for hours, but is ready in minutes for you!
1 Package Curly's BBQ Pulled Pork
5 Provolone cheese, sliced
2 cups Cabbage, shredded
1 Apple, julienned
1/4 Carrot, shredded
1. Turn on your Panini press to a medium/high heat.
2. In a mixing bowl mix shredded cabbage, apple, mayonnaise, lemon juice and salt and pepper, and set to side.
3. Heat the Curly’s BBQ Pulled Pork in a microwave for 2 minutes.
4. Build sandwich: on your first piece of bread, add the Curly's BBQ Pulled Pork, top it with the cabbage mixture and a slice of cheese followed by the second piece of bread.
5. Place your sandwich in the Panini press for approximately 1-2 minutes.
6. Serve and enjoy!

domain: food


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Coveti embraces individuality. For this, exclusivity is key. Expect one-off designs, limited edition, bespoke, and made to order pieces. Explore a world of exciting emerging designers, handpicked just for you.
The Kaftan Edit
Ultra-feminine silhouettes for modest-friendly dress code
If you're still wondering, this blazer is the red line you should cross between formal wear and casual wear. There's always an exception for every rule, yours is the lightweight drift blazer limited edition piece.


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Pesembur Rojak Mamak
Pasembur is a dish familiar to the Northern Peninsular of Malaysia. Mainly in Penang where you can enjoy a bowl of Pasembur along Gurney Drive. It’s also known as Rojak Mamak.
|500g Sweet Potatoes (boiled til cooked)|
|5 Cups Water|
|2 Shallots (ground)|
|1 1/2 Tbsp Chilli Paste|
|3-4 Tbsp Oil|
|2-3 Tbsp Roasted Peanuts (pounded)|
|1 Tbsp Thick Soy Sauce|
|Tamarind Juice: (Combine, squeeze and strain juice)|
|1/2 Tbsp Tamarind|
|3 Tbsp Water|
|1/2 Tsp Salt or to taste|
|3 1/2 Tbsp Sugar|
|1/4 Tsp Lime Juice|
|Vegetables for the Rojak:|
|5 Pcs Yellow Soybean Cakes (Taukwa), fried and thinly sliced|
|200g Yam Bean (Turnip/Sengkuang), shredded|
|1 Cucumber (shredded)|
|2 Hard-boiled eggs, halved|
|3 Potatoes boiled in jackets, skinned then cut|
|200g Beansprouts, scalded|
- Peel and boil the sweet potatoes until cooked. Then place in a blender with half the portion of water into a runny paste.
- Pan-fry the peanuts, peel, and pound.
- In a pot, heat up cooking oil then add the shallots and chilli paste and cook until fragrant. Add in the sweet potato paste and the remaining water. Bring to a low boil for 5 minutes.
- Add the tamarind juice, sugar, lime juice. Stir well and simmer for 2-3 minutes.
- Add the soya sauce and ground peanuts. Set aside for use later.
- Place a little of each vegetable, eggs and pour a ladle of gravy over and serve immediately.