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domain: hobby


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The Basset Bleu De Gascogne: A Comprehensive Guide to the Breed’s Characteristics, Temperament, and Care
The Basset Bleu De Gascogne is an attractive scent hound of medium size that has an even temperament and is a pleasure to have as a companion. These dogs are loyal and attentive, yet playful, and have a good appetite for life. They have a long, silky coat that comes in a variety of colors and is easy to care for. Read on to learn more about this breed!
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The Basset Bleu De Gascogne is an intelligent, loving, and devoted breed. They are good-natured and tolerant, making them excellent family companions. They do very well with children and are also gentle and affectionate with other pets. They are friendly and can be quite playful. With training, they can be taught to obey commands, although they may be stubborn at times.
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The Basset Bleu De Gascogne is an affectionate and loyal companion that makes a great family pet. They are smart, patient, and good-natured, and with the proper training, they can be a delightful addition to any home.

domain: pet


text:
Percutaneous tracheostomy: Comparison of three different methods with respect to tracheal cartilage injury in cadavers—Randomized controlled study
- 1Department of Otorhinolaryngology and Head and Neck Surgery, Semmelweis University, Budapest, Hungary
- 2Department of Anaesthesiology and Intensive Therapy, Semmelweis University, Budapest, Hungary
- 3Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, Budapest, Hungary
Background: Performing tracheostomy improves patient comfort and success rate of weaning from prolonged invasive mechanical ventilation. Data suggest that patients have more benefit of percutaneous technique than the surgical procedure, however, there is no consensus on the percutaneous method of choice regarding severe complications such as late tracheal stenosis. Aim of this study was comparing incidences of cartilage injury caused by different percutaneous dilatation techniques (PDT), including Single Dilator, Griggs’ and modified (bidirectional) Griggs’ method.
Materials and methods: Randomized observational study was conducted on 150 cadavers underwent post-mortem percutaneous tracheostomy. Data of cadavers including age, gender and time elapsed from death until the intervention (more or less than 72 h) were collected and recorded. Primary and secondary outcomes were: rate of cartilage injury and cannula malposition respectively.
Results: Statistical analysis revealed that method of intervention was significantly associated with occurrence of cartilage injury, as comparing either standard Griggs’ with Single Dilator (p = 0.002; OR: 4.903; 95% CI: 1.834–13.105) or modified Griggs’ with Single Dilator (p < 0.001; OR: 6.559; 95% CI: 2.472–17.404), however, no statistical difference was observed between standard and modified Griggs’ techniques (p = 0.583; OR: 0.748; 95% CI: 0.347–1.610). We found no statistical difference in the occurrence of cartilage injury between the early- and late post-mortem group (p = 0.630). Neither gender (p = 0.913), nor age (p = 0.529) influenced the rate of cartilage fracture. There was no statistical difference between the applied PDT techniques regarding the cannula misplacement/malposition.
Conclusion: In this cadaver study both standard and modified Griggs’ forceps dilatational methods were safer than Single dilator in respect of cartilage injury.
Prolonged invasive mechanical ventilation of a patient via orotracheal tube may cause several early and late intubation-associated complications including pneumonia, pressure ulcers of the surrounding tissues, tracheal stenosis, etc. It is also highly responsible for patient discomfort due to swallowing incompetence, impaired communication ability and poor mouth hygiene. To avoid these complications and enhance patient comfort currently it is widely accepted to perform either surgical or percutaneous tracheostomy for patients who need prolonged mechanical ventilation (1–4).
The first widely accepted percutaneous tracheostomy technique was described by Pat Ciaglia, which involved a series of sequential dilatations using a set of seven dilators of progressively larger size (5). A variant of this technique, using a single tapered dilator is called the Ciaglia Blue RhinoTM (Cook Medical, Bloomington IN, United States) method which is now most commonly used, especially in the United States and United Kingdom (6). There is a very similar method to this when a balloon is introduced over a guidewire to dilate the stoma (7). In PercuTwistTM (Teleflex, Athlone, Ireland) technique, a specially designed screw-type dilator is introduced over a guidewire and its rotation dilates the stoma (8). Another widely used technique was developed by William Griggs who suggested to use specifically modified forceps enabling the performance of the main dilation in a single step (9). The other great advance of this technique is that all the aforementioned methods require pressure over the anterior wall during dilation risking a possible posterior tracheal wall injury (6). An interesting alternative was described by Fantoni, where the dilator and the tracheostomy tube are pulled through the larynx in a retrograde fashion (10).
The spread of percutaneous techniques raised the number of successful bedside tracheostomy operations, and percutaneous dilatational tracheostomy (PDT) gained popularity to become the technique of choice for long-term airway management in mechanically ventilated patients. However, these interventions have their own hazards: the major early complication is hemorrhage and one of the most dangerous and relatively common late complication is tracheal stenosis. Severe tracheal stenosis occurs in 3%–12% of patients undergoing PDT (11, 12) which is considered an excruciating late complication of tracheostomy with significant impact on quality of life. Mechanisms of postintubational and posttracheostomy tracheal stenosis are not clearly identified. After a long term intratracheal intubation the cause could be ischaemia of the mucous membrane, pressure ulceration or granulation tissue, while in case of trauma tracheal stenosis is rather caused by cartilage injury as it was described in trauma patients and in canine model (13–19). A. Marchion et al published a molecular, histolgical study in 2022. They found that the reason could be aberrant wound-healing, fibrotic scarring and iatrogenic aetiology as trauma of the tracheal mucosa, and of the tracheal cartilage; (20). As there is a possible causative relationship between the fracture of the cartilage during the PDT procedure and the aforementioned tracheal stenosis, in this study we wanted to investigate how common cartilage fracture is when performing PDT on cadavers with the two most common methods, namely Griggs’ and single dilator (Rhino), and we also reevaluated and compared our previously described modified Griggs’ method (in which we make a wider incision, blunt preparation, and bidirectional forceps dilation of the tracheal wall, e.g. standard horizontal and novel vertical) with them (21). The further late complications such as tracheomalacia, tracheoinominate artery fistula and tracheoesophageal fistula occur each in <1%. Tracheaomalacia usually caused by the high cuff pressure of the tracheal tube. This and the intraoperational perforation of the posterior tracheal wall could also be the cause of the tracheoesophageal fistula. If the tracheostomy tube is positioned under the 4th tracheal cartilage the risk of the development of the tracheoinominate artery fistula is higher. These late complications cannot be investigated on cadavers (12–27).
Materials and methods
Our cadaver study was performed at the 1st Department of Pathology and Experimental Cancer Research of Semmelweis University with permission of Semmelweis University Regional and Institutional Committee of Science and Research Ethics (117-1/2006 SE-RKEB; 2014.03.17). Data were collected anonymized. Data analysis and statistical plan was written and filed with a private entity before data were accessed.
The simple-blinded observational method was carried out by two experts in the field of surgical and percutaneous tracheostomies—by an intensive care specialist and an ENT surgeon with additional specialization of intensive care medicine—both for more than 5 years at a University hospital. The first expert had performed the procedures and the second one had checked the results, respectively.
Cadavers (who were not intubated before death) were collected; autopsies as well as preparation of the airway complexes from the cadavers following tracheostomy were carried out by mortuary technician. Site of tracheal cannula insertion, estimation of tracheal cartilage damage were scored by the non-operator expert without the knowledge of the insertion technique.
Insertion site was scored as 1: cricoid-1st tracheal ring space; 2: 1st-2nd tracheal ring space; 3: 2nd-3rd tracheal ring space. Estimation of ring injuries was classified as: 1: none; 2: one ring fractured; 3: two or more rings fractured.
Data about the cadavers [e.g., date and time of death (72 h or more before intervention), age, gender] as well as the lack of exclusion criteria (e.g., previous laryngo-tracheal disease, injury, previous tracheostomy, visible or palpable damage on the neck) were collected and recorded on individual sheets with registration numbers.
Randomization was carried out by a 6-sided dice: Nr 1-2, 3-4 and 5-6 were linked with traditional Griggs (n = 51), modified Griggs (n = 55) and Single Dilator methods (n = 44), respectively.
Cadavers were positioned in standard hyperextended position for tracheostomy, and the exact method was performed according to the randomization. Details of the procedures are briefly presented below  and were discussed previously elsewhere.  Percutaneous tracheostomy kits available from the market were used. For traditional and modified Griggs’ technique Portex® GRIGGS© Percutaneous Dilation Tracheostomy Kit with Blue Line Ultra® tubes in different sizes were used according to the needs. For Ciaglia method Portex® ULTRAperc© Single Stage Dilator Technique Kit with Blue Line Ultra® tubes were applied in the same manner.
Skin incisions were performed at the midpoint of cricoid cartilage and jugulum. Traditional Griggs’ technique:, no surgical preparation, direct tracheal puncture and unidirectional (transverse) tracheal dilation were performed followed by the insertion of tracheostomy cannula (9).
Modified Griggs’ technique: a maximum 50 mm-wide skin incision, surgical pretracheal tissue preparation, and careful, visualized bidirectional (transverse and longitudinal) intercartilaginous forceps dilation of tracheal wall were performed (21). The wider horizontal skin incision provided enough space for secure pretracheal preparation until the tracheal wall could be visualized as well as palpated in our modified technique. Preparations were performed using blunt technique, and Griggs-modified dilating forceps were used in order to ascertain tissue resistance followed by the tracheal puncture according to Watters recommendations (28). Visualized tracheal wall puncture next to the palpating finger and continuous aspiration of air secured correct intratracheal needle position according to Paran’s recommendation (29). Insertion of the guidewire followed by the introducer was the following step. Griggs-modified dilating forceps were introduced using the guidewire, according to the standard method, as deep as approximately 15 mm from the axis of rotation, and bimanual horizontal dilation was performed. Forceps were rotated 90° in longitudinal direction afterwards, and another bimanual forceps dilation was carried out in the vertical direction. After removing the forceps tracheostomy tube was inserted into the trachea using the guidewire.
The Ciaglia Blue Rhino single dilator method was performed as reviewed by SP Ambesh (30). After a transverse 20 mm skin incision we identified the anterior tracheal wall by palpation to assess the puncture site. The tracheal dilation was performed by a curved, gradually tapered dilator in a single step, than we inserted the tracheostomy tube via using a guidewire.
Upper airway complex was anatomized by a mortuary technician with maximal care for non-traumatic extraction. Site of insertion and posterior tracheal wall were inspected and recorded by the non-operator expert, then dissection of the posterior wall was carried out. Exact cannula position was checked and ring fracture inspected and palpated to avoid any “hidden” fracture covered by mucosa. The process was completed by photo documentation.
Pearson chi-square tests were applied using SigmaStat 3.5 program (Systat Software Inc., San Jose, CA, United states) for statistical evaluation. To calculate the sample size of the study, the frequency of tracheal cartilage injury was the variable of interest. We assumed that a minimum of 20% difference was considered clinically important, and that in combination with our previous results of 9% from earlier experiments were used for the calculations.  A type one error of 0.05 and a required (statistical) power of 0.80 were set. A minimum of 150 cadavers were required based on the conditions detailed above.
We carried out PDTs in 150 cadavers (69 female and 81 male) with different types of dilatational techniques in the period of 2015 March 01–2017 February 24. All data is available in Supplementary Material. Standard Griggs technique was applied in 51 cases, modified Griggs technique in 55 cases and Single Dilator technique in 44 cases according to randomization. During autopsy, we found that in four cases the tracheostomy tube was misplaced - not in the trachea but in the surrounding tissues (all done by Single Dilator method). We excluded these results; thus statistical analysis consists of 146 cases.
According to the time elapsed since death we divided the patients into two groups, an early post-mortem (less than 72 h passed since death), and a late post-mortem group (81 vs. 65 subjects). Our preliminary assumption was that cartilage rigidity varies with the time elapsed after death thus there would be an increase in cartilage injury in the group of cadavers in whom PDT was carried out more than 72 h after death (late post-mortem group). Table 1 shows that the frequency of cartilage injury was 53.09% (43/81 cases) and 58.46% (38/65 cases), respectively, hence there was no statistical difference between these two groups (p = 0.630). Figure 1 presents characteristic images of tracheal injuries found during autopsies. Thus for further analysis we summarized all subjects irrespective of the time elapsed from death until PDT was carried out. We also recorded the age of subjects at death and according to this we compared cartilage injury occurrence in subjects younger (34/71) and older than 70 years (31/75). No statistical difference was found between these two groups (p = 0.529), thus cartilage fracture does not depend on the age of the deceased. There was also no statistical difference (p = 0.913) in the cartilage injury occurrence between women (29/67) and men (36/79).
FIGURE 1. Characteristic of tracheal injuries during autopsies (A): Tracheostomy aperture [blue arrow] without fracture (posterior tracheal wall dissected, internal view). (B) “One-ring” fracture [yellow arrow] (posterior tracheal wall dissected, internal view). (C) “Multiple-ring” fracture [black arrow] (anterior view for demonstrational purposes).
As the next step we compared the three techniques applied according to two aspects, whether the occurrence of cartilage injury depends on the dilatational techniques and whether there is any difference in the position of tracheostomy. For the latter we accepted the tracheostomy at “proper position” if the tube was inserted between the 1st and 2nd or between the 2nd and 3rd cartilages according to the standards. Raw data are shown in Table 2. When performing tracheostomy with standard Griggs’ technique, there was no cartilage injury observed in 26 cases, and injured cartilages were detected in 25 cases (injury occurrence: 49.02%), meanwhile 31 tubes were inserted in good position and 20 were malpositioned (malposition occurrence: 39.22%). In case of modified Griggs’ method these results are 32 vs. 23 (41.82%) for injury and 36 vs. 19 (34.55%) for malposition, and 7 vs. 33 (82.50%) and 22 vs. 18 (45.00%), respectively, when using Single Dilator.
TABLE 2. Relationship between cartilage injury or tracheostomy tube position and the method of intervention.
Statistical analysis revealed that the method of intervention was significantly associated with cartilage injury, when comparing either standard Griggs’ with Single Dilator (p = 0.002; OR: 4.903; 95% CI: 1.834–13.105) or modified Griggs’ with Single Dilator (p < 0.001; OR: 6.559; 95% CI: 2.472–17.404) technique. In each case we found that there is an increased risk of cartilage injury when using the Single Dilator technique. However, we could not detect any statistical difference between standard and modified Griggs’ techniques with respect to cartilage injury (p = 0.583; OR: 0.748; 95% CI: 0.347–1.610). We also analyzed the malposition occurrence, but there was no statistically significant difference between the three PDT techniques applied (Griggs vs. modified Griggs: p = 0.767; OR: 0.818; 95% CI: 0.371–1.803; Griggs vs. Single Dilator: p = 0.733; OR: 1.268; 95% CI: 0.548–2.935; and modified Griggs vs. Single Dilator: p = 0.413; OR: 1.550; 95% CI: 0.673–3.572). Statistical data are shown in Table 3.
TABLE 3. Statistical analysis of the methods of intervention according to cartilage injury and tracheostomy tube position.
Tracheostomy was traditionally performed by surgeons in the operating room, but thanks to the development of percutaneous dilatational techniques nowadays is a routine procedure done by intensivists in most of the Intensive Care Units. PDT helps shorten overall time of tracheostomy procedures by decreasing the waiting time for operating room and general anesthesia (31–33). Another great review also suggests that PDT is the procedure of choice for tracheostomy because of its reduced procedure time and medical cost (34) There are several good quality prospective randomized studies which confirm the PDT’s superiority against surgical techniques in critically ill patients (35–38). PDT is associated with significantly fewer wound infections and unfavourable scarring, and it may also reduce the risk of bleeding and mortality compared with surgical tracheostomy in critically ill patients according to systematic reviews (39, 40). Bedside percutaneous tracheostomy was experienced as a safe method in a retrospective review of more than 3000 procedures (41). However, in a recent study, there was no statistically significant difference in the one-year mortality of patients undergoing prolonged mechanical ventilation whether receiving tracheostomy or not (42), furthermore there were no significant differences in the intraoperative and postoperative bleeding and in mortality in recent meta-analysis (43).
Although there are several studies, meta-analyses and excellent reviews which compare the different PDT techniques (6,30,44–47), there is still no consensus between physicians on which technique has the lowest major complication rate. Our aim in this study was to compare the two most widely used PDT techniques—namely the Griggs’ and the Single Dilator—and also our previously suggested modification of Griggs’ version (21) in cadavers, in respect of cartilage injury, which is believed to take important part in the development of tracheal stenosis (48, 49).
According to our data, using a single tapered dilator significantly increases the risk of cartilage injury in cadavers compared to both standard and modified Griggs’ methods, in accordance with some previous experts’ observations (30). The single dilator is a round shaped device with permanently increasing diameter which is used with a continous force against the tracheal wall therefore the trachea cartilage could be broken easier in this case. A mild single unidirectional (transverse) tracheal dilation is performed in Griggs method, while performing modified Griggs technique a visualized bidirectional (transverse and longitudinal) intercartilaginous dilation is made which both can reduce the risk of cartilage injuries (50).
We have suggested a modification to the classical Griggs’ method in order to decrease the complications of PDT in our previous study (21). We have found that this modification caused a remarkable decrease in the number of injured tracheal cartilages. One of the main drawbacks of that study was that the procedures were not blinded, i.e., the same investigator performed and evaluated identical procedures. Thus, now we redesigned and reevaluated our previous study using a randomized, blinded approach. Our new data still showed a decreased risk of cartilage injury with this modification; however, this reduction was not statistically significant. Further elevation of the sample size may emphasize the difference. Cartilage fracture was independent of aging, gender and the time elapsed since death. According to statistical analysis the level of intervention was not different between the three groups, however, it is worth mentioning that cannula malposition occurred less commonly in the modified Griggs’ group.
We suggest making a quite wide (50-mm) horizontal skin incision for the procedure. One might say that this increases the risk of major bleeding and makes the procedure longer but at the same time it provides enough space for secure pretracheal surgical blunt preparation until the tracheal wall can be visualized and palpated making critical intervention (i.e. tracheal puncture with partially lost airway) shorter and probably safer. Another important aspect is, that with good visibility bronchoscopy is nearly unnecessary, thus it is easier to avoid the significant rise of PaCO2 and consequent respiratory acidosis which occurs during bronchoscopy even when applying increased tidal volume and large diameter endotracheal tube (51).
The obvious limitation of our study is that PDTs were made in cadavers, which could influence cartilage flexibility, so cadaver’s tracheal cartilages could be more rigid than in case of living tissue. Performing PDT cartilage injury/fracture could be rare in living tissues but the correlation of the number of the cartilage injuries using different methods could be demonstrated on cadavers.Tracheal injuries were more common in our study (81/146 subjects, 55.48%) than what we would expect according to our clinical experience, although it was still less than mentioned in another PDT cadaver study (83%) (52). Even if there was no significant difference in cartilage injury between the two groups defined by the post-mortem time elapsed, there was a higher incidence in the late post-mortem group, which corroborates the presumption that it could influence our data. It is also important to mention that cartilage injury could not only occur during the insertion of the cannula but also during autopsy when it was removed for evaluation, thus it could further increase its incidence.
In conclusion, in cadavers we found that forceps dilatational methods are safer than Single dilator with respect to cartilage injury. Although we did not detect statistical significance, we still suggest the use of bidirectional dilatation with forceps, as cartilage injury and cannula malposition incidence was the lowest in the group where this modification was applied. Prospective study and long-term follow-up of patients undergoing PDTs would be necessary to further confirm its superiority over other methods.
Data availability statement
The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.
The studies involving human participants were reviewed and approved by Semmelweis University Regional and Institutional Committee of Science and Research Ethics (117-1/2006 SE-RKEB; 2014.03.17). Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements.
GÉ designed and wrote the research study; FB and GO performed the research; FB and GO and LÉ collected the data; JT analyzed the data; FB and JT wrote the paper. JG and GÉ, and MSZ revised the manuscript. All authors approved the final manuscript.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Authors are grateful to Professor András Matolcsy Gergely Rácz M.D. PhD, János Zalavári and all other contributing members of the 1st Department of Pathology and Experimental Cancer Research of Semmelweis University for supplying cadavers and providing special help during dissections. The critical reading of the manuscript by Professor László Tamás, Associate professor Balázs Hauser and Judit Laki management consultant (Semmelweis University) are acknowledged with many thanks.
The Supplementary Material for this article can be found online at: https://www.por-journal.com/articles/10.3389/pore.2023.1610934/full#supplementary-material
SUPPLEMENTARY DATA SHEET S1 | The generated datasets.
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23. Khanafer, A, Hellstern, V, Meißner, H, Harmening, C, Schneider, K, and Henkes, H. Tracheoinnominate fistula: Acute bleeding and hypovolemic shock due to a trachea-innominate artery fistula after long-term tracheostomy, treated with a stent-graft. CVIR Endovasc (2021) 4(1):30. doi:10.1186/s42155-021-00216-8
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30. Ambesh, SP, Pandey, CK, Srivastava, S, Agarwal, A, and Singh, DK. Percutaneous tracheostomy with single dilatation technique: A prospective, randomized comparison of Ciaglia blue rhino versus Griggs' guidewire dilating forceps. Anesth Analg (2002) 95(6):1739–45. t. doi:10.1097/00000539-200212000-00050
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37. Melloni, G, Muttini, S, Gallioli, G, Carretta, A, Cozzi, S, Gemma, M, et al. Surgical tracheostomy versus percutaneous dilatational tracheostomy. A prospective-randomized study with long-term follow-up. J Cardiovasc Surg (Torino) (2002) 43(1):113–21.
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Keywords: percutaneous tracheostomy, tracheal cartilage injury, Tracheal stenosis, Griggs, Ciaglia Blue Rhino
Citation: Bódis F, Orosz G, Tóth JT, Szabó M, Élő LG, Gál J and Élő G (2023) Percutaneous tracheostomy: Comparison of three different methods with respect to tracheal cartilage injury in cadavers—Randomized controlled study. Pathol. Oncol. Res. 29:1610934. doi: 10.3389/pore.2023.1610934
Received: 08 November 2022; Accepted: 09 January 2023;
Published: 19 January 2023.
Edited by:Andrea Ladányi, National Institute of Oncology (NIO), Hungary
Copyright © 2023 Bódis, Orosz, Tóth, Szabó, Élő, Gál and Élő. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Fruzsina Bódis, email@example.com

domain: literature


text:
Festive Smoking and Curing Masterclass
In the run up to the festive season there are many curing and smoking recipes that could bring a whole host of wonderful, traditional dishes to your table. If you want to go the extra mile with your seasonal meals, this practical Festive Smoking and Curing Masterclass will give you the confidence and know-how to create flavoursome festive ingredients such as glazed ham, brined / BBQ turkey and beautiful smoked salmon.
Hot and Cold Smoked Fish
Pigs in Blankets
Curing & Smoking is not just for Christmas but this class will allow you to learn the skills to make great produce in time for the coming festive period either for your own table and enjoyment or even given as a handmade artisan gift!
Bod Griffiths runs Vale House Kitchen with his wife Annie, and after six years of working with a whole range of fantastic tutors is excited to start leading his own courses. He grew up helping his Grandmother in the kitchen, and it’s from her that he got his love for traditional skills like baking bread and making preserves, as well as a profound appreciation for cooking in tune with the seasons. As an adult, he lived and worked in London,…
Steven lamb is a curing & smoking expert, teacher, presenter, culinary consultant and award-winning author. After a background in media, Steven’s food career began nearly 20 years ago when he joined Hugh Fearnley-Whittingstall’s River Cottage team, regularly appearing in the tv series and being instrumental in establishing the internationally acclaimed cookery school on the devon / dorset border. Beyond River Cottage, Steven’s extensive food knowledge and talent for live hosting has put him at the centre of many of the…

domain: food


Montpellier MS135W Low Frost Fridge Freezer in White
If you’re looking for a fridge freezer with space and style then the MS135W is the perfect solution.
Ideal for the medium sized home, the fridge has two adjustable glass shelves, a salad crisper and door storage and there are two roomy drawers in the freezer.
Reversible doors mean you can locate it in any space in your kitchen.
Low Frost means that there will be a reduced amount of frost and ice build-up; consequently you will need to defrost the appliance less frequently. With glass shelves between the freezer compartments, it’s also easier to defrost and clean your freezer.
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text:
GOP, Democrats miss certification deadline
JACKSON — A spokeswoman for Republican Secretary of State Delbert Hosemann says Mississippi primary runoffs will take place Aug. 23 as scheduled.
Hosemann’s office issued a news release late yesterday afternoon saying the state Democratic Party had failed to certify its results from the Aug. 2 primaries. A short time later, the Democratic Party filed the certified numbers.
The secretary of state’s news release says parties had a Aug. 12 deadline to file certified primary results, and the Republicans filed their results Aug. 15.
Pamela Weaver, spokeswoman for the secretary of state’s office, says Hosemann staffers worked after hours to prepare a ballot to send to circuit clerks.
Ballot preparation is a formality, because clerks had already been allowing people to vote absentee since Aug. 13, and Weaver says those votes will count.
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- Voters to decide whether hunting, fishing is constitutional right
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domain: news


text:
Classic Thai adopts the slow, honest food philosophy by being dedicated and having integrity to the staggering and complex flavours of Classic Royal Thai Cuisine in every rendition of the cuisine.
Sadly too often Thai food is compromised and watered down, producing a dim reflection of its amazing flavour combinations. This is often due to lack of Thai culinary knowledge, laziness, cost cutting and incorrect palate assumptions. Along with a number of other Thai restaurants we strive to safeguard Thai Culinary Heritage.
We do not just meet your needs, we anticipate them. Your wishes meet our skills. Inspired by the elegant yet vibrant food of Royal Thai Cuisine we promise to tantalize the senses with our ever evolving menu..
Classic Thai always remains new and exciting. When it comes to flavour whilst we do have a theme of heat, we don’t agree with super spicy but rather we opt for complexity and rounded richness of flavour.


text:
Laura Prepon stunned last night at the 2014 Critics' Choice TV awards.
But if the Orange Is the New Black star wasn't careful, she could have had a major wardrobe malfunction with her cleavage-baring Alice + Olivia gown.
"The girls are out a little bit tonight," Prepon said on the red carpet.
But get this, she didn't use any topstick tape to keep everything in place and covered up.
Wasn't she nervous? "A little bit," Prepon said, laughing. "A little bit."

domain: entertainment


What neighborhood you live in can often be point of contention among city-dwellers. In some cases, the geography of city neighborhoods can leave little doubt about neighborhood boundaries, as when bold features like major avenues, highways, railroads, and waterways make for obvious boundaries. Other cities have neighborhoods that are explicitly defined by city governments, often for political representation purposes. In a similar case, Chicago’s 77 “community areas”, which often include multiple neighborhoods within them, provide concrete boundaries at a hyper-local level, primarily for urban planning purposes.
But for many other cities, neighborhood boundaries, and even names, are vague, ambiguous, and inconsistent. Where I am in D.C., I’m all too familiar with this phenomenon. From blogs covering the “in-between” neighborhood areas to the repeated attempts at redefining parts of the city “already assigned” to certain names, the practice of place-making through neighborhood naming and boundary negotiation is fairly common. I’m more of a traditionalist, and I want current notions of neighborhood that have a historic significance and track record to stay put. Besides, just because a neighborhood undergoing gentrification is changing rapidly, and that change is not uniform across the neighborhood, it doesn’t mean a splintering of area identities is needed. But stepping back from my persuasion, I would also argue that this attempt to hyper-define the urban landscape is a perfectly natural practice. Whether we reside in dense cities or rural countryside, most people want to connect with their “place” and be able to define part of themselves in relation to their named surroundings. When some people deem geographic naming conventions for their place to be weak or outdated, the inclination is to redefine and recharacterize the place, which is just what these D.C. neighborhood re-namers are going for.
I remember attending a Trivia Night in Columbia Heights where one question was “Name the 4 neighborhoods surrounding Columbia Heights.” “Only four?” I thought. “Oh boy”. The quizmasters later revealed the answers: “U Street Corridor (Shaw), Adams Morgan, Mount Pleasant, and Petworth”. And with that, trivia anarchy erupted. “What about Pleasant Plains!” “What about Park View!” “Ummm Sixteenth Street Heights?!” The quizmasters stood in humble silence, realizing their question wasn’t as cut and dry as they had predicted. For those familiar with D.C. geography, my guess was that the quizmasters took Columbia Heights as extending east all the way to the US Soldiers and Airmens Home and Washington Hospital Center, thereby eliminating Pleasant Plains and Park View, while considering everything north of Spring Road and Rock Creek Church Road to be Petworth, thereby eliminating Sixteenth Street Heights. While certain neighborhoods certainly have more cultural and social supremacy than others, it’s not a surprise that people who live in the less popularly named areas will want to stick up for their hood. It becomes a part of identity, after all.
What D.C. could use is a project like the one conducted by Bostonography, a fantastic site that creates beautiful maps and infographics all about Boston. The site conducted an online survey asking users to outline city neighborhoods on a map as they saw them, then mapping the certainty of results. While the problem of neighborhood name supremacy and “sub-neighborhoods” still lingers, the overarching design of the experiment yielded interesting results that work towards a more uniform understanding of popular notions of neighborhood borders. This is really a must read for Bostonians, with its hood-by-hood analysis, and the maps themselves are very well done.
While I’ve been caught up in the geographic shapes and boundaries of neighborhoods in this post, Bostonography’s Andy Woodruff reminds us about what’s truly important:
Although we talk a lot about boundaries, this post included, the maps here should also remind us that neighborhoods are not defined by their edges—essentially, what is outside the neighborhood—but rather by their contents. And it’s not just a collection of roads and things you see on a map; it’s about some shared history, activities, architecture, and culture. So while the neighborhood summaries above rely on edges to describe the maps, let’s also think about the areas represented by the shapes and what’s inside them. What are the characteristics of these areas? Why are they the shapes that they are? Why is consensus easy or difficult in different areas? What is the significance of the differences in opinion between residents of a neighborhood and people outside the neighborhood?


Vaccination rollout in adults alone is unlikely to completely stop Covid 19 cases spreading in the UK and early sudden release of restrictions is likely to lead to a large wave of infection, according to a new modelling study.
The research published in The Lancet Infectious Diseases journal found that gradual release of control measures, high vaccine uptake, and a vaccine with high protection against infection is essential to minimise future waves of infection.
This analysis was done before early real-world data from vaccination rollout studies. Preliminary findings suggest that the vaccine does offer a level of protection against infection, but the exact level is still unclear – for this reason the authors examine a range of levels of protection against infection.
The authors note that their model does not account for the emergence of new variants, to which the vaccine might offer less protection, nor for the effects of waning immunity, which might necessitate additional vaccination. They also note that they are unable to look at the effects of relaxing individual control measures.
UK ranks third globally for vaccine doses administered
Professor Matt Keeling, from University of Warwick, UK, said: “We also found that early sudden release of restrictions is likely to lead to a large wave of infection, whereas gradually easing measures over a period of many months could reduce the peak of future waves.
"The huge success of the UK’s vaccine programme so far coupled with the government’s gradual roadmap for easing restrictions are a cause for optimism. However, some measures, such as test, trace, and isolate, good hand hygiene, mask-wearing in high-risk settings, and tracing from super-spreader events, may also be necessary for some time.”
Vaccination may offer a potential exit strategy for the pandemic and the UK currently ranks third globally for the total number of vaccine doses administered. This study modelled the combined interaction of the UK vaccination rollout with different scenarios of relaxing control measures, to predict the R number and deaths and hospital admissions due to Covid-19 from January 2021 to January 2024.
The findings suggest that although vaccination can substantially reduce R, it may not be enough to drive R below 1 without other control measures. Under the most optimistic scenario for protection against infection (85%), the R number is estimated to be 1.58 without other controls.
Gradual relaxation, as opposed to immediate release of control measures, may reduce future waves of infection. For example, partial release of control measures in February, 2021, was predicted to lead to a wave of infection that peaks at 1,670 deaths per day, but gradual release of measures over the course of 5 months or 10 months leads to waves that peak at 430 and 46 deaths per day, respectively.
Although vaccination substantially decreases overall deaths, because no vaccine’s protection against symptomatic disease is 100%, the authors note that some people who have been vaccinated will still die of Covid-19. If the vaccine offers 60% protection against infection, the authors predict that 48% and 16% of deaths may be in individuals who have received one or two doses of the vaccine, respectively.
Dr Sam Moore, from University of Warwick, UK, added: “We’re rapidly learning more about vaccine efficacy as vaccination programmes are rolled out across the world. Since we conducted this study, new evidence suggests there may be a higher level of protection against severe disease offered by both the Pfizer-BioNTech and Oxford-AstraZeneca vaccines than the level we assumed.
"This may reduce the size of future hospital admissions and deaths we estimated, making future waves more manageable for the health service. As for protection against infection, some preliminary findings have suggested that the vaccine does offer a level of protection against infection, but the exact level of protection offered by vaccines is still unclear. We will continue to update our predictions as new data on vaccine efficacy becomes available.”
The authors caution that vaccine uptake is likely to be uneven (clustering among certain households and socioeconomic groups), potentially giving rise to pockets of infection, as control measures are relaxed. They stress the importance of intensive test, trace, and isolate capabilities to target these pockets of infection.


text:
Irritable Bowel Syndrome, otherwise known as IBS, has an unknown cause. Although stress, poor diet, and abnormal muscle spasms in the colon aggravate the condition all that is known is that the muscles in the intestines and colon spasm irregularly and cause abdominal cramp, bloating, nausea, and indigestion.
Women are more likely to suffer from IBS than men. Scientific studies show female hormonal changes may play a role in this factor. There may be strong evidence to this since women with IBS tend to report exacerbations during their menstrual cycles, and also feel a stronger need to seek out IBS relief. Even men, though, can experience exacerbations in their IBS symptoms along with women when sick with intestinal illnesses and other sicknesses that bring the immune system down.
Your doctor may suspect that you have IBS due to your symptoms. There are specific symptoms that a doctor will look for which is called the “Rome Criteria”. Your doctor may order other medical tests to be sure that you don’t have another health problem that causes the same symptoms. To diagnose IBS you may be asked to take some blood tests and a physical exam. Some other tests that may be included are a Lower Gastrointestinal (GI) Series, which x-rays your abdomen to see any problems in the Large Intestine. Another test is a Colonoscopy, which is when the doctor inserts a tiny camera into your colon to take pictures to see if there are any problems there.
IBS is a disease that can easily be misdiagnosed because there currently is no laboratory test or imaging test that doctors can use to help diagnose it. IBS symptoms are the main driver for diagnosis and this makes a doctor’s task more difficult since the disease shares so many characteristics with other illnesses. IBS is often mistaken for a number of other diseases including infectious diseases, parasites, food allergies, or lactose intolerance. IBS symptoms also closely mimic the symptoms of a patient with celiac disease.
The reason why Bavolex is unique is because it has been proven to be more effective than other products and it is scientifically formulated. Bavolex contains plant extracts and enzymes that are specifically targeted towards certain angles in relieving IBS. Some of these ingredients consist of:
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domain: biology


text:
(Photo credit: inquirer.net)
Despite the 0-2 record under new coach Chito Victolero, this isn't the same as least season's debacle under Jason Webb. This isn't an ominous sign of things to come, at least that's what we would like to believe anyway. No, this team, save for a few Grand Slam leftovers, is a team that is trying to build on and off court chemistry as well as an overall identity.
So who are the Hotshots, exactly?
Well, they were the PBA's token glamour boys. Pretty boys who could back it up on the court. They weren't known for their offense or defense, they were simply known as a solid bunch and a classy organization over all. Like San Miguel's own yellow (then blue) version of Alaska.
When Tim Cone took over, he built a new culture. When he left, everything fell apart. Some guys wanted to change the blueprint, others were not sold on the idea. In comes Victolero, who is no Webb but is definitely no Cone either, plus a new star in Paul Lee. Of course there is going to be a rough period.

domain: sports


text:
The only surprising factor about Saturday's Australian Cup protest is the time taken by Racing Victorian stewards to announce the decision.
Yet in what is described as "the capital of upheld protests" the verdict has been criticised.
Awesome Rock, with Steve Baster riding hell-for-leather, between the 300 metres and 200 metres shifted out when not sufficiently clear of Preferment, handled by Hugh Bowman, no slouch in the finish or as the prosecuting counsel, ably assisted by Chris Waller.
Preferment, to say the least, was inconvenienced, and the finishing margin was only a short half head. Had the decision gone against him serious consideration would have to be given to dropping protests from the rules of racing and making races an open slather.
Victorian stewards, under Terry Bailey, have had to adjudicate on three protests in recent weeks. Apart from the Australian Cup, the talented but somewhat erratic Palentinto has been involved in two – the C.S.Hayes at Flemington lost to Tivaci and the following week, the Australian Cup, successfully defended against Tarzino.
Palentino shifted out suddenly at the 900 metres in the C.S. Hayes taking the running of Tivaci, handled by Craig Williams, and forcing him wide from that point before being beaten a half head.
The evidence given by Williams put him in a "courtroom gem" category by many.
Stewards have to deduce whether they are satisfied, had the incident not occurred, what the result would have been.
"It's subjective," Ray Murrihy, the Racing NSW chief steward, maintained. "Certainly the closer to the finish of a race the easier it is to come to a conclusion".
But Murrihy didn't rule out that early interference was positive grounds for objection.
No doubt protests are becoming more regular. Wise guys in Melbourne maintain it is due to Bailey's reception to them.
However, stewards are using advanced technology and jockeys can now view videos of possible interference before taking action.
My first major protest was the infamous leg pull by Mel Schumacher, riding Blue Era, on Tommy Hill (Summer Fair) in the 1961 AJC Derby at Randwick.
A flickering black and white head on film, reminiscent of the Charley Chaplin era, proved that Schumacher had a death grip, in a remarkable feat of horsemanship, on Hill's knee which played a vital role in the result. Protest upheld.
Unlike Victoria, steward's inquiries were open to the press. Down south it was only introduced around a decade ago and wasn't in practice for the 1969 Caulfield Cup featuring the honey tongue of Roy Higgins on Big Philou against Nausori, with Des Lake up. Lake was a better rider than a talker.
Nasauri had won by a neck but stewards found in favour of Big Philou. Higgins was an idol. Lake an ex-pat on a Sydney stayer. Racegoers howled.
Mainly I wonder why involved parties are even asked to give evidence. Lodge the protest and let the stewards come to a finding. But insiders maintain Higgins was a key influence with Big Philou.
Throughout my protests I always had the impression if a horse was racing erratically the jockey was duty bound to stop riding and straighten his mount, particularly if he has a rivals on his outside.
Murrihy confirmed this is still a rule.
"These days jockey move out seeking better ground but that doesn't entitle them to take others out with them," Murrihy added.


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From Hip-Hop to R&B and Pop, find the latest music news, interviews, features, videos & more.
Pharrell’s new commercial for his Louis Vuitton line of jewels, Blason, is funky, creepy, and sexy all at once.
Snoop Dogg is writing a new theme song for ABCs daytime soap opera ‘One Life To Live.’
Hope their group name is better than Danity Kane. New tracks from the guy crew: ‘Got Me Going’ and ‘Together.’
Jay-Z’s latest video premieres at Rocafella.com.
‘American Idol’ alum Clay Aiken says he’s no Justin Timberlake, and that’s OK being ‘vanilla.’ So, if Clay is vanilla, what does that make Justin?
Apparently, the only way to beat Beyonce’s hype machine is to perform half-naked on stage. Wait, Beyonce already does that.
Not even a whole week after getting grazed in the head by a bullet, the rapper makes a song about it. Although he says he’s not trying to be Pac or 50, he makes reference to getting shot at least 11 times if you count it.
Erykah Badu’s new video for the new single, ‘Honey.’
Read a review, track-by-track of Janet Jackson’s upcoming album ‘Discipline,’ due out Feb. 26.
Why there’s ‘beef’ between these two is beyond comprehension. It just seems like Shyheim was just looking for an opportunity to get at somebody through controversy. It’s still funny though.
Producer Jermaine Dupri takes you behind the scenes of this showcase to spotlight up and coming artist signed to Island Def Jam.
Wu-Tang Clan member Masta Killa, a long time vegetarian, has been voted ‘most friendly hip hop artist’ 2008 by PETA.
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domain: artistic


An 87-year-old East Aurora woman has died after a crash Sunday afternoon in West Seneca, police said Monday.
Mary L. Young's car was struck just as she turned off Leydecker Road onto Southwestern Boulevard at about 4:15 p.m. Sunday, according to West Seneca Police.
Young was rushed to the Erie County Medical Center where she had been listed in critical condition. Several occupants of the other vehicle involved also were taken to ECMC to be treated for what police described as minor injuries. Southwestern Boulevard was closed until about 6 p.m. while West Seneca's Accident Investigation Unit examined the scene.
Police have not released any other details and have not said what may have caused the crash. No charges were reported as filed against either motorist as of Sunday evening.


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Awe Interactive's acclaimed rhythm roguelike first person shooter can now be played on PlayStation and Xbox consoles.
The operatic rock shooter was originally slated to release this Summer for consoles. It will also be playable on PS5 and Xbox Series X/S.
Awe Interactive's rhythmic first person shooter, which sees Valkyries battling Hel's forces to rock opera tunes, is coming to consoles.
Three developers have already signed on with Playtonic Friends for their next games.
A new chapter and boss, and two new difficulty modes also added.


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to entice you to visit
How pretty. I love the ones with the pink mixed in.
Lovely flowers. Yellow and pink look so pretty together.
Bettyl, what a feast for the eyes! It's mid-winter here in Moldova, -14C this morning and everything outside is gray and ugly with the snow not white but filthy and frozen. I long for spring!I could look at your photos all day ;)
Beautiful flowers and such intense colors - especially in the second photo.
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The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews.
BACKGROUND Carriers of germ-line mutations in BRCA1 and BRCA2 from families at high risk for cancer have been estimated to have an 85 percent risk of breast cancer. Since the combined frequency of… Expand
Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001.
Because the causes of most lymphoid neoplasms remain unknown, comparison of incidence patterns by disease subtype may provide critical clues for future etiologic investigations. We therefore… Expand
Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial.
CONTEXT Screening for ovarian cancer with cancer antigen 125 (CA-125) and transvaginal ultrasound has an unknown effect on mortality. OBJECTIVE To evaluate the effect of screening for ovarian… Expand
Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship.
IMPORTANCE The 2008 Physical Activity Guidelines for Americans recommended a minimum of 75 vigorous-intensity or 150 moderate-intensity minutes per week (7.5 metabolic-equivalent hours per week) of… Expand
Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults.
IMPORTANCE Leisure-time physical activity has been associated with lower risk of heart-disease and all-cause mortality, but its association with risk of cancer is not well understood. OBJECTIVE To… Expand
Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium.
BACKGROUND Common genetic variants in immune and inflammatory response genes can affect the risk of developing non-Hodgkin lymphoma. We aimed to test this hypothesis using previously unpublished data… Expand
50-year trends in smoking-related mortality in the United States.
- M. Thun, Brian D. Carter, +5 authors S. Gapstur
- The New England journal of medicine
- 23 January 2013
BACKGROUND The disease risks from cigarette smoking increased in the United States over most of the 20th century, first among male smokers and later among female smokers. Whether these risks have… Expand
Leisure Time Physical Activity of Moderate to Vigorous Intensity and Mortality: A Large Pooled Cohort Analysis
Analyzing data from over 650,000 individuals, Dr. Steven Moore and colleagues report that greater amounts of leisure-time physical activity were associated with higher life expectancy across a wide… Expand
Factors influencing the age at natural menopause.
To examine sociodemographic, menstrual, reproductive, and other factors which may influence the age at natural menopause, the authors analyzed data from a large series of women participating in a… Expand
ABO blood group and the risk of pancreatic cancer.
- B. Wolpin, A. Chan, +5 authors C. Fuchs
- Journal of the National Cancer Institute
- 18 March 2009
BACKGROUND Other than several rare, highly penetrant familial syndromes, genetic risk factors for sporadic pancreatic cancer are largely unknown. ABO blood type is an inherited characteristic that in… Expand

domain: health


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The State Bank of Pakistan (SBP) has announced that the Federal Investigation Agency (FIA) should examine unlawful cryptocurrency transactions.
In response to ProPakistani’s concerns, an SBP representative said the FIA would be the proper body to examine any illicit cryptocurrency transactions. He made it clear that the central bank does not have the right to investigate anyone for engaging in criminal behaviour.
The spokeswoman said the central bank has issued a clear direction to the banking industry regarding the illegality of dealing in cryptocurrencies, citing the recent FIA seizure of over 1,000 bank accounts.
In response to a question, the spokeswoman said SBP was studying cryptocurrencies for its future monetary policies in the country. “The matter for cryptocurrencies in Pakistan is still sub judice,” he remarked, prohibiting public discussion.
Despite promises of a regulatory shift toward recognising digital assets as legal currency, the situation is presently exceedingly unsettled. Circular No. 3 of the Banking Policy and Regulation Department (BPRD) issued 6 April 2018 prohibits the sale and purchase of virtual assets.
These individuals had made 2,923 transactions worth Rs. 51 million using online exchanges including as Binance, Coinbase, and Coinmama. Individuals who used Binance P2P to acquire or sell cryptocurrency had their bank accounts suspended.
As of July 2021, Pakistan ranks 15th globally in digital currency use. Pakistanis presently own cryptocurrencies worth $20 billion, according to FPCCI President.

domain: law


NexusMC is a fast-growing leading Minecraft Network. Developed for the LGBTQ+, we offer a range of servers from Survival, Skyblock and Creative, with more servers being actively developed. Come say hi!
You can join the NexusMC Minecraft server by copying the IP address below.
Then, navigate to your Minecraft Launcher, and from the title screen click Multiplayer > Direct Connect. Paste in the server IP and hit "Join Server"!
No, the NexusMC Minecraft Server does not support Votifier. However, you can still show your support by voting for them. It will help show their server to more people!
The NexusMC Minecraft Server is located in United States (US)


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Ghana Latest Football News, Live Scores, Results - GHANAsoccernet
Ruthless Cherries thrash Tykes to go top
Napoli Confirm Stadium Rename in Honour of Diego Maradona
FIFA approves maternity leave for players
TMW - Benfica turned down by Santos on VERISSIMO
Liverpool 'eyeing up Brighton's Yves Bissouma as a potential replacement for Georginio Wijnaldum'
Eric Dier reveals how and why he was ready to quit Tottenham
Real Madrid without Sergio Ramos for trip to Sevilla
Real Madrid squad for Sevilla: Sergio Ramos left behind
Pep Guardiola jokes about when he will stop coaching: Do you believe him?
The keys to New England's playoff run? Arena, Gil, Bou and spending
Transfer News & Rumours
Last day of voting for PFA fans player of the month
Dele Alli key for Tottenham
Van Gaal hails United win
Forster keeps out The Gunners
Chelsea - Inter Milan targeting John Terry
Manchester City love Manuel Pellegrini
Argentina/ Independiente, today German Denis will sign
Juventus after Fulham\'s Moussa Dembelè
Tony Pulis insists Berahino will stay at West Brom
FIFA Confederations Cup emblem gives life to Russian dream
Tottenham and Chelsea to share Wembley Stadium in 2017
Arsenal, Wenger and Koeman in tunnel bust-up
Leicester, Vardy fairy tale: \"Volley good show\"
Arsenals poor finishing costing them the title
SPAIN/ REAL MADRID, could offer Yaya Toure a return to Spanish
Benfica, Jovic: \"I arrived in the best club of Portugal\"
Klopp impressed by Vardy
Manchester City - Toure also linked with China
Atletico Madrid - Jackson Martinez sold to Chinese club
EXCLUSIVE TMW / PREMIER LEAGUE: Jackson is gone for Diego Costa will return in June
Southampton boss Ronald Koeman praises Arsenals Sanchez
Markovic blames Rogers for Anfield exit
Quique Sanchez Flores thinks Guardiola replicate success in Premier League
Aston Villa manager Garde may resign
Falcao to China after Atlético deal fails?
Vardy to sign with Leicester until 2019
Klopp warns Guardiola of Premiership\'s \"real competition\"
Pep Guardiola will target key signings at City
Terry to stay?
Markovic slams Rodgers
Yaya Toure to leave Manchester City?
Guardiola to change the mindset of English football?


In this tutorial, we'll show you how to create an Alibaba Cloud Container Service application environment running on Docker containers managed by a Swarm cluster built up on Alibaba Cloud Elastic Compute Service (ECS) instances that we have already set up in a previous tutorial.
In the past, developers had to install, run, and monitor their development and production system environments on racks of physical machines in gigantic server rooms. Nowadays, new containerization technology with virtual management tools, such as Docker Swarm and Kubernetes, allows developers to manage and monitor their production and development environments running collections of Docker application containers directly through Alibaba Cloud's Container Service, using its console web-based user interface.
Alibaba Cloud's Container Service is a scalable, high-performance, container management product that allows you to orchestrate and manage containerized application lifecycles with either Docker Swarm or Kubernetes. Container Service comes with an automatic built in Server Load Balancer that is installed Pay-As-You-Go.
Alibaba Cloud's Container Service offers multiple application release methods, including continuous integration, and also supports a microservices architecture. By offering a simplified user interface console setup for a container cluster, which integrates with Alibaba Cloud's virtualization, storage, network, and security services, Alibaba Cloud's Container Service is the perfect cloud environment for running, managing, and monitoring containerized application environments.
Docker is an open source, virtualization management tool that allows you to develop, deploy, manage, and monitor applications and collections of applications that run within containers. This process is known as containerization. Docker Swarm is a clustering, scheduling, and orchestration tool for such systems and environments that are running on multiple and scalable Docker containers.
A Docker container is launched by running a Docker image which is an executable package that includes everything needed for running an entire application: code, runtime, libraries, environment variables, and configuration files. A container is a runtime instance of a Docker image.
You can run multiple containers at the same time on the same instance, or on a Docker Swarm cluster of instances. The running containers are managed by Docker instead of an operating system's hypervisor; and Docker, unlike a hypervisor, provides redundancy and failover if one or more of the cluster nodes experience any problems.
Docker is lightweight and efficient and can manage complex systems built up of multiple application images. You can build Docker containers locally, or deploy them to the cloud, and you can run them anywhere; scaling up and down wherever necessary.
Docker is easy to set up, install, and run on a single Alibaba Cloud ECS instance. A large-scale containerized environment running industry level applications and systems needs a reliable and scalable orchestration and monitoring system. Alibaba Cloud's Container Service provides system administrators and DevOps teams with the vast clustered architectures they need to manage extensive containerized environments.
Before we can install a suite of running Docker containers with Alibaba Cloud's Container Service Docker Swarm option, we need to have an Alibaba Cloud Container Service Docker Swarm cluster ready and available for implementing our containerized systems.
In a previous tutorial, we showed you how easy it is to set up a Docker Swarm cluster for running a containerized environment with Alibaba Cloud's Container Service. We will use the same running cluster in this tutorial to build out an application environment. We will build an environment with a web server built from an image, and a web application built from an orchestration template, both coming as part of the Alibaba Cloud's Container Service product offerings.
You will need an Alibaba Cloud account. If you don't already have one, head over to the Free Trial page to access $300 worth of Alibaba Cloud products in the Alibaba Cloud New User Free Trial.
Let's get started.
Let's first make sure our Docker Swarm cluster is running. Head over to the Container Service console page in your Alibaba Cloud account.
You will arrive at the Container Service console page.
Make sure the Container Service – Swarm option is selected before clicking the Cluster option on the left side menu.
If all's well, you should see a Running cluster in a Healthy state.
Go to the Applications menu option and click Create Application.
In the Basic Options, add a name for the application, a version number (default is 1.0), select the cluster you wish to use for the application (we only have one running cluster, so this is defaulted), and select your release strategy:
Standard release deletes any earlier versions of your application before deploying the new version. This is sufficient for our tutorial. Blue-green release is an active-standby option for applications which need to continue to run without interruption when updating.
Add a description of your application and select the Pull Docker Image option.
Now click Create with Image.
You will move forward to the Configuration options. In General Settings, click Select Image.
Select the nginx option and click OK.
The latest Docker image version is pulled from remote Docker repositories by default.
You can now click Create on the right-hand side.
You will see a confirmation that the application is being created.
Now you will see your nginx application in both the Applications and Services menus.
In the Applications menu, click the nginx running application.
Now, we can configure the networking.
Add the Port Mapping details for HTTP/HTTPS 80 and 443, and the Container Port.
Now click Update.
You will see the application creating and then eventually settle into a Running state.
Click the Applications menu option.
Click through to the application details.
In this view, you will see a number of tabs. The Services tab shows the state of the application.
Click the Containers tab. In this view, you will see all the VPC network port settings, the container IP, and the node IP. You also have the option to monitor the container.
Click the name link.
You will see a number of graphs, including the container's CPU, memory, IO, and process utilizations over time.
Now click the Logs tab.
Here you will see the logs for the container. Now click Events.
This option will show you a list of events on the container. Now click the Routes tab.
Here you will see the container's endpoint. Go ahead and click the link.
You should see confirmation that you have set up the nginx container correctly and it is running.
Now let's integrate WordPress with nginx on the same cluster.
This time, we will use an orchestration template. Go back to the Container Service console and click Applications. Check you're on the correct cluster (we still have just the one) and click Create Application.
The procedures are exactly the same as before but instead of clicking Create with Image, we will click Create with Orchestration Template. We can leave the Docker Image option unselected in this case.
For those familiar with the Docker ecosphere, you can run your Docker compose files here. We will click Use Existing Orchestration Template.
Let's select WordPress.
As you can see, the console populates with the relevant Docker compose commands and configuration.
We need to edit one of the configurations now.
This configuration change should mean that any requests to aliyun port 80 from the test domain URL should route to WordPress.
Now click Create and Destroy.
You will see your application running. Click the Applications menu and you will see WordPress creating.
Once the application is created, you will see it in the running state. Click through to the application.
As before, you will see a number of tabs. WordPress has two tabs as it needs a database and a web application in order to run. Click the Containers tab.
The Containers tab shows details of all the different running Docker containers the application requires.
Logs and Events tabs show details as we saw before. If you click Routes, you get the WordPress endpoint URL which you will need to set up your application.
Go ahead and click the endpoint.
You can now set up your WordPress site running on the nginx webserver we set up previously.
First, we explained how we had already built an Alibaba Cloud Container Service Docker Swarm cluster in preparation for building out a containerized environment and we checked it was running correctly.
Next, we explained about the Alibaba Cloud Container Service product and how you can use it with both Swarm and Kubernetes containerized environments. We also explained how these products need clusters to run on and how Alibaba Cloud will auto set up clusters built from Elastic Compute Services (ECS) and even include a Server Load Balancer as part of the auto set up.
We then showed you how to build an Alibaba Cloud Docker Swarm Containerize Service of applications starting by pulling a nginx webserver Docker image down remotely from Docker. We then used an Orchestration Template to pull down a WordPress image which allows for much more developer flexibility.
Thanks for reading and don't forget to check out the other products and services Alibaba Cloud offers.
Alibaba Clouder - January 24, 2019
Alibaba Clouder - June 11, 2020
Alibaba Clouder - November 20, 2017
Alibaba Clouder - July 24, 2020
Alibaba Clouder - February 27, 2019
Alibaba Clouder - April 20, 2018
More Posts by Alibaba Clouder


Let me come clean: I’m pro-choice. I’m also pro-health, pro-women’s rights, and pro-education.
I used to enjoy buying the little pink things with ribbons on them, like notebooks and pens, knowing that some of my money was going to the Susan G. Komen foundation. I think that a foundation that raises awareness about breast cancer and donates money to prevention, screening, and health care is a good thing.
However, I think that the re-evaluation of their funding is hurtful. I think that denying support of Planned Parenthood is shameful.
I’m sure that I don’t have all the facts. I really hope that I don’t. I don’t like to think that the Komen foundation pulled support of Planned Parenthood for something frivolous (for example, I have seen the assumption that Komen is anti-choice). “The Komen Foundation’s leadership did not respond to Planned Parenthood requests to meet with the Komen Board of Directors about the decision.” (from Planned Parenthood’s site). I think that Komen should have met with Planned Parenthood.
Here are a few links:
Baltimore Sun OpEd
Monterey Herald OpEd
NY Times : which is awesome since it explains that Bloomburg is donating money to Planned Parenthood since ““Politics have no place in health care,” he said in a statement. “Breast cancer screening saves lives and hundreds of thousands of women rely on Planned Parenthood for access to care. We should be helping women access that care, not placing barriers in their way.””
And from the Facebook page “It’s OK to be Takei“:
A supporter sent this to Planned Parenthood …
….. “This is for all the anti-choice, anti-women people out there.
Listen up. You can spend every minute of every day trying to force the rest of us to live by your ideology. You can go after federal funds for health care and pressure private organizations like the Susan G. Komen for the Cure Foundation to stop funding breast cancer screenings for poor women. You can try to make it impossible to get birth control. But you know what you can’t do? You can’t win. You can’t break us. Planned Parenthood isn’t just a family of organizations. It’s a movement. It’s women and men of all ages who believe that health care — including reproductive health care — is a basic human right. We are millions strong. We are everywhere. We act, we give, and we do whatever it takes to make sure that Planned Parenthood is there for the women, men, and teens who rely on them. Know this: When you go after Planned Parenthood and the people they serve, you go after ME. I stand with Planned Parenthood. I stand with them against anyone who wants to stop women from receiving the health care they need. I stand with them today, tomorrow, and for as long as I need to.”


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VIP Launch Party & Legacy of Pride Awards
June 1, 2022 @ 7:00 PM - 10:00 PM EDT| FREE
Established in 2012, The Legacy of Pride awards celebrate and honor the efforts of SGL/LGBT community members, allies and organizations who make extraordinary contributions to Harlem’s SGL/LGBT community. Legacy of Pride recipient selections are based on a demonstration of excellence in arts and entertainment, business, community, humanitarian efforts, medicine, politics, and sports.
Join us this year as we honor some our community’s champions and enjoy live entertainment, food and fun!
FREE Admission with a $50 or $25 Suggested Donation.

domain: sociology


Boris Egorov, the guide of the 7 Summits Club, reports from Papua New Guinea:
A cultural program has begun on the island of Papua. Today we visited three tribes, watched theatrical performances arranged especially for us. We looked into the homes of the aborigines and received detailed answers to our numerous questions about life in this country, before and after the arrival of the white man. We were well fed, and in the evening there was time for leisure. We played chess and played preference until nightfall. The rest continues. Tomorrow we will continue to explore the customs of the indigenous population, and we hope to finish our game of cards.


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Advertising is everywhere. Learn the tricks of the marketing trade, from billboards to commercials.
Who spiked the punch? Vodka or rum, mixed drinks or shots, get recipe ideas for your next party.
Relax, meditate or just chill out to the electronic beats and instrumentals of ambient music.
Flex your creativity by exploring performing arts, literature, music, visual arts and more.
Think ordinary is boring? Explore the weird, the strange, the obscure, and the downright freaky.
Do you love the 12-bar blues? Explore the best blues festivals, songs and more, from Chicago to Memphis.
Find out more about buzzfeed-com.
Explore the Caribbean islands here. It's cheaper than going on a cruise, and you won't run into any pirates.
Miss Saturday morning cartoons? Get your dose of cartoons - funny, political and more - here.
Discover funny pictures and more about cats, from cute kittens to fat cats. We promise you'll smile.
Fascinated by the lives of the rich and famous? Don't miss the latest celebrity news and gossip.
With order comes disorder. Learn about chaos theory, controlled chaos and the butterfly effect.
Whether you like romantic comedies or black comedies, have a laugh by Stumbling through funny films.
Where would movies or video games be without computer graphics? Learn about animation, modeling and more.
Explore dancing, from ballroom to salsa, and soon you'll be wow-ing everyone with your moves.
Explore the art of design, from graphic design on the Web to interior design in the home.
No more stick figures! Uncover your inner artist and the world of sketching, charcoals and pastels.
Do you dream of traveling through Italy or France? Learn more about Europe (and plan your next vacation).
Are the hamsters at the pet store too tame for you? Learn about sugar gliders, bobcats, parrots and more.
Are you a foodie? Expand your culinary horizons with new recipes, cooking ideas and nutrition tips.


The error you should not make is ignoring the value of a CNC machine when discussing crucial things you need in a business that specializes on accuracy cutting. You can be sure that you will get more revenues when you invest in a CNC machine since it leads to increased productivity and enhances quality. Even if you feel that you should acquire a new CNC machine, you should remember that you will employ a lot of resources on it. If you have limited resources, you may consider buying a used CNC lathe machine from dealers in your area. Nevertheless, you must observe due diligence when determining the most appropriate CNC machine for sale if you want to get value for your cash. Content of this item covers what you should not ignore when selecting a pre-owned CNC lathe for sale.
The maintenance of the machine can determine how it will function. It implies that you should check if the previous owner of the used lathe machine handled it with care when buying it. Ask the dealer to give you evidence that the machine has been maintained and repaired correctly by the previous owner. Buying a well-maintained machine can guarantee you that you will get quality results from it.
You should understand that the spindle of the lathe machine can decide its functionality. Hence, you should be sure to consider the condition of the spindle of the lathe you intend to purchase. You should not hesitate to run the machine on sale to learn whether the spindle bearings are functions properly. It should dawn on you that spindle bearings that produce an unwanted noise will imply that the CNC machine is damaged. Besides, you should learn that the hotness of the spindle bearings should not change even when the machine has operated for long.
Never make the mistake of buying a used CNC lathe without taking into account its cost. The charges on the used CNC lathe will rely on its hours of utilization, brand, and condition among other things. If you do not want to experience cash hiccups; you should ascertain that you will buy an affordable CNC lathe machine. Compare the costs of multiple used CNC machines for sale in your region to decide the most affordable. However, the cost of the lathe machine should not cause you to sideline its quality.
You will require to maintain and renovate the CNC machine from time to time after acquiring it. The availability of spare parts for the used CNC lathe is, therefore, something you must consider when buying it. If you do not wish to go through a difficult time when repairing the CNC lathe machine, you must ascertain that you can find its spare parts in the shops.