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Age-related differences in toxicokinetic processes of deoxynivalenol (DON) and deoxynivalenol-3-glucoside (DON3G) were studied. DON3G [55.7 µg/kg bodyweight (BW)] and an equimolar dose of DON (36 µg/kg BW) were administered to weaned piglets (4 weeks old) by single intravenous and oral administration in a double two-way cross-over design. Systemic and portal blood was sampled at different time points pre- and post-administration and plasma concentrations of DON, DON3G and their metabolites were quantified using validated liquid chromatography-tandem mass spectrometry (LC–MS/MS) and liquid chromatography–high-resolution mass spectrometry (LC–HRMS) methods. Data were processed using tailor-made compartmental toxicokinetic (TK) models to accurately estimate TK parameters. Results were statistically compared to data obtained in a previous study on 11-week-old pigs using identical experimental conditions. Significant age-related differences in intestinal and systemic exposure to both DON and DON3G were noted. Most remarkably, a significant difference was found for the absorbed fraction of DON3G, after presystemic hydrolysis to DON, in weaned piglets compared to 11-week-old piglets (83% vs 16%, respectively), assumed to be mainly attributed to the higher intestinal permeability of weaned piglets. Other differences in TK parameters could be assigned to a higher water/fat body ratio and longer gastrointestinal transit time of weaned piglets. Results may further refine current risk assessment concerning DON and DON3G in animals. Additionally, since piglets possibly serve as a human paediatric surrogate model, results may be extrapolated to human infants.
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The authors are grateful towards Prof. Adams (Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna) for the synthesis of the DON3G standard, used for animal and analytical experiments. The financial support from the European Union’s Horizon 2020 research and innovation programme under grant agreement H2020-MYCOKEY-GA 678781 is gratefully acknowledged.
This work was supported by Horizon 2020 (H2020-MYCOKEY-GA 678781).
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The authors declare that they have no conflict of interest.
All applicable international, national and institutional guidelines for the care and use of animals were followed (EU 2010; KB 2013).
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Catteuw, A., Devreese, M., De Baere, S. et al. Investigation of age-related differences in toxicokinetic processes of deoxynivalenol and deoxynivalenol-3-glucoside in weaned piglets. Arch Toxicol 94, 417–425 (2020). https://doi.org/10.1007/s00204-019-02644-x
- Plasma protein binding

domain: chemistry


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Perfect for the holidays, my pomegranate dark chocolate bark recipe is made with slivered almonds and sea salt. The perfect simple dessert!
I love a quick and easy dessert recipe for the holidays. While I have big baking days I also love having a quick go-to, easy, crowd-pleasing treat I can make in a pinch. This holiday bark does all of that!
Honestly, I can eat chocolate bark just by itself but sprinkle with almonds, sweet pomegranate arils and just a pinch of finishing salt– you have something that's beautiful, delicious and easy to make.
You can make this bark in the morning and have it set and ready to go by the afternoon or evening. No fuss kind of dessert! It does have fresh fruit (pomegranate arils) so you want to eat within a few days. If you want something that lasts longer you can omit the pomegranate (although it is such an amazing flavor with the chocolate) and use chopped dried cranberries.
To add even more holiday colors you can swap the almonds with pistachios which will taste just as good, possibly better depending on how much you love pistachios. 😉
Pomegranate Chocolate Bark
- 1/2 cup pomegranate arils
- 16 oz dark chocolate chips or discs
- parchment paper
- 1/4 cup sliced almonds
- 1/4 tsp sea salt
- Remove arils from pomegranate if necessary.
- In a double boiler melt chocolate, stirring frequently, until smooth (be careful not to burn the chocolate). Option to melt chocolate in microwave stirring every 30 seconds until melted.
- Line a sheet pan w/ parchment paper. Pour chocolate onto sheet pan.
- Sprinkle evenly w/ pomegranate arils, sliced almonds and sea salt.
- Place sheet pan in refrigerator until bark is solid (~1 hour).
- Once solid, loosely break into ~2x2” pieces.
- Store in refrigerator in small container or resealable bag.

domain: food


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By Glamsham Editorial
As per latest reports, Suraj Pancholi, the boyfriend of Jiah Khan, was on Tuesday remanded in police custody till June 13 by a Mumbai court. This came after prosecution said his interrogation was necessary following allegations of threat, assault and rape against him by Jiah Khan in her alleged suicide note.
The son of Aditya Pancholi and Zarina Wahab, was yesterday arrested after being booked under IPC Section 306 for allegedly abetting Jiah's suicide. The actress ended her life a week after she ended her life at her Juhu home.
It is believed that the police told the court that they have recovered five love letters exchanged between Suraj and Jiah and they wanted to verify the contents.
According to reports, the CCTV footage of the hotel and the house where the two went the day Jiah ended her life, has also been recovered.

domain: news


ShareFile's native iPad app took two months to pass Apple's approval process. The CEO shares his insights into surviving the in-app purchasing test.
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Slideshow: Apple iPad 2 3G Teardown
ShareFile on Wednesday released a native iPad application for its file-sharing and backup platform, and it was a long time coming--it had sat ready and waiting since May. The holdup? The app took an arduous, two-month trek through the Apple approval gauntlet.
CEO Jesse Lipson said ShareFile got swept up by Apple's increasing--yet sometimes inconsistent--enforcement of its in-app purchase (IAP) rules. Lipson had been concerned about his company's iPhone app prior to its launch earlier this year because of growing buzz around approval obstacles, but the worry was unnecessary--the iPhone app was approved in less than a week.
ShareFile's new iPad app is functionally very similar to its older iPhone sibling, aside from the obvious difference in screen size. So Lipson said he was "blindsided" when he had to fight a much tougher battle, undergoing two rejections and making a series of changes necessary to appease the final review board. The first red flag was that the iPad app sat in the review queue for about three weeks with no word from Apple. The reviewer assigned to it eventually rejected it because it didn't incorporate the IAP system.
"It was a very big surprise to us. We were totally shocked," Lipson said. "We were also disappointed that they took so long to get back to us."
Apple's terms essentially dictate that other companies must use its IAP system and fork over 30% of revenue generated by the app. ShareFile challenged the reviewer's rejection on the basis that the IAP didn't apply to its Software-as-a-Service (SaaS) model. Lipson said he has no issue paying Apple a finder's fee for new customers acquired via an iOS app, but that the IAP system simply doesn't mesh with ShareFile's platform. He added that IAP is best suited for one-size-fits-all consumer offerings, rather than full-fledged SaaS applications for businesses.
"We have fairly complex business plans," Lipson said. "IAP is just not sophisticated enough to capture that." For example, ShareFile needs to offer business users the flexibility to adjust for changing bandwidth, storage, or license needs. "Their system doesn't capture the situations that a true SaaS app like ours has to deal with," Lipson said. The argument didn't sway the reviewer, however, and the app was rejected a second time. That led to a follow-up phone call with the reviewer.
"She basically swore up-and-down there was no way our app was going to get approved without IAP," Lipson said, adding that the reviewer commented that was especially true for a file-sharing app. ShareFile decided to appeal to Apple's final review board. The decision wasn't without some risk: If the review board sided with the initial reviewer, then ShareFile's hands would be tied: Either implement IAP, or forge a mobile strategy without an iPad app.
It's not like ShareFile had much choice. The bootstrapped, 70-person firm fights for its share of the crowded file-sharing and backup market, and it knew several of its competitors had already rolled out iPad apps--some without implementing IAP--or were in the process of doing so. ShareFile focuses on business customers, for whom mobility is becoming a must. Lipson said around 10% of users have begun using one of ShareFile's smartphone apps since they launched at the end of March.
ShareFile has also rolled out a native app for Android tablets as it rounds out its mobility support, but Lipson said uptake has been slow so far. That's a function of Apple's dominance to date in the tablet market--and the influence it wields over iOS applications as a result.
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2017 State of IT ReportIn today's technology-driven world, "innovation" has become a basic expectation. IT leaders are tasked with making technical magic, improving customer experience, and boosting the bottom line -- yet often without any increase to the IT budget. How are organizations striking the balance between new initiatives and cost control? Download our report to learn about the biggest challenges and how savvy IT executives are overcoming them.


Posting its 13th consecutive year of increased earnings, Comprehensive Care Corp. of Newport Beach announced that the board of directors approved a 4-for-3 stock split, payable July 16 to shareholders of record June 28.
The directors also authorized a first-quarter cash dividend of 8 cents a share, payable Aug. 15 to shareholders of record July 31. The company had earlier paid a 10-cent dividend on the smaller number of shares outstanding prior to the split.
"What we are doing is simultaneously giving a 33.3% increase in stock to our present shareholders and paying a higher (total) dividend," said B. Lee Karns, CompCare's chairman and chief executive officer. The company is best known for its drug and alcohol treatment centers.
Karns said that after the stock split is paid, the number of outstanding shares will rise to 15,122,000 from 11,370,000. The new dividend would give current shareholders a 32-cent annual dividend on the four new shares, compared with a 30-cent dividend a year ago on three shares.
Karns said the board's action was due to the company's higher fiscal year-end performance. CompCare estimated its net earnings for the fiscal year ended May 31, 1985, at $17.1 million, compared to the $14.1 million it posted for fiscal 1984. And for the final quarter of the year, CompCare estimated earnings of $5 million, compared with the $4.2 million it reported for the same three-month period the year before.
Karns said final figures would be released next month.
In addition to hospital-based chemical-dependency treatment programs, CompCare also develops and manages programs in general psychiatry, eating disorders, other specialty areas of behavioral medicine, and in physical medicine and rehabilitation.


In the mid 1990s bald eagles began showing up on lakes along the Yadkin River chain. At the time, Alcoa Power Generating Inc, set out to encourage the population by preserving habitat. Large areas of open water, dense undeveloped forests made the Yadkin Lakes the ideal spot for the majestic birds. Despite being our national symbol, bald eagles were once a rare site in North Carolina as well as most parts of the country. Up until 2007 they were on the endangered species list. Most people grew up never having seen one in the wild. Now thanks to conservation efforts, bald eagles are a common sight on all of the area lakes. High Rock Lake is known to have several active nests and a few non-active.
This page is dedicated to bald eagles around High Rock Lake. We will continue to build this information, pics and videos for the benefit of all eagle lovers. Scroll down for more. Please check back often for updates.
Bald Eagle Picture Galleries
Bald Eagle Watching
Carolyn Phillips Canzonieri and her husband Mike live on High Rock Lake. Several times a week they venture out on their pontoon boat in search of bald eagles and other birds. The couple admits that they weren't really into "Birdwatching" until they moved to the lake.
Like so many people, the Canzonieris were not aware that there are lots of bald eagles on and around High Rock Lake. One day they started noticing the large birds and curiosity led them on a journey to seek out and photograph these majestic creatures. In the video below they take us along on one of their eagle watching tours.


American Idol Rejects-Fashion Singers
Sharon E. Clarke accompanied Deron Shields to American Idol casting in 2012. American Idol rejected Deron. Sharon refused to let it go, so she made a song. After the song was created, Sharon began to search the web for a recording studio. She found Jahmane Bright, the owner of Triangle Studio, we all came together and made the song and the rest was history.
TRIANGULAR RECORDING STUDIO.
SHAARON E. CLARKE


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If you can’t grow it, fake it! There’s no shame in embracing faux florals this season, because no one will know the difference!
Floral Designer Leslie Nelson from the Emporium at Thanksgiving Point shares her silk flower secrets.
To get your faux floral arrangement started, make sure you have the right tools. You’ll need floral tape, dry oasis, moss, wire, hot glue gun, wire cutters and scissors and a knife.
GET CREATIVE WITH CONTAINERS – Containers are important for the style and design of the piece. Think outside the box and find unusual containers, or embellish an old wreath to create a new look. Use and old basket or make one out of chicken wire and fill with silks and hang on your front door and change for each season. Be creative and have fun with it.
INVEST IN GOOD SILK FLOWERS – For creating a realistic and beautiful long lasting silk arrangement, do not use cheap flowers. Spend a little more and get good quality flowers. The more realistic the flowers are, the nicer the arrangement will be and the longer it will last. The price range for quality, long-lasting silk flowers range from $5-$18. We don’t recommend using flowers from the dollar store. The best places to find good quality silks are at a wholesale house, but you need to have an account so the best place is at your favorite retail flower shop or craft store. Good silks can be a little spendy but worth it in the end. The Emporium at Thanksgiving Point has a great selection of silk flowers.
USE REAL FLOWER COLORS – Try to avoid silk flowers that are not true to flowers colors that actually grow. (e.g blue roses: Have you ever seen a real blue rose? Probably not, so avoid those flowers.)
ELONGATE STEMES FOR CONTRAST – You can create longer stems by adding a stick or stem to a shorter flower with florist tape and wire.
USE BLOOMING BRANCHES FOR HEIGHT –Sometimes you can even add some real branches from your yard.
DUST AND CHANGES FLOWERS OFTEN – Flowers can be a dust collector. You can use a flowers spray cleaner or just lightly dust every month. Also, changing out your flowers for seasons is a nice way to switch it up and keep it fresh and new and clean.
Learn more at the Creative Gathering Classes at the Emporium:
“Fresh Flowers 101”
Tuesday, April 16, 6-8 pm
Erin, a floral designer at Thanksgiving Point, will teach the basics of arranging flowers, and help you create a beautiful bouquet for your home.
9th Annual Tulip Festival at Thanksgiving Point
April 12-27 (closed Sundays)
The 9th annual Tulip Festival features more than 250,000 tulips in bloom with thousands of spring flowers. Enjoy daily events such as free gardening demonstrations and garden tours. Also, listen for the traditional melodies of bagpipers and other musical entertainment in the gardens. Other events include Dutch Day, Tulip Princess Pageant and the Half Marathon. There’s no better place than Thanksgiving Point Gardens to celebrate the return of spring and the renowned tulip.

domain: design


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Gary Trosclair, DMA, LCSW, is a Jungian analyst in private practice in New York City and Westchester County, NY. He is president of the New York Association for Analytical Psychology and serves on the faculty of the Jung Institute of New York. He is the author of I’m Working On It in Therapy: How to Get the Most Out of Psychotherapy; and of the blog The Healthy Compulsive Project. His new book, The Healthy Compulsive Project: Taking the Wheel of the Driven Personality, will be published this year.
Seminars and study tours in extraordinary places and online, too.

domain: psychology


Boyer’s new Rhapsody in Red, White & Blue will be performed in all 50 of the United States; Naxos will release the recording with pianist Jeffrey Biegel and the London Symphony Orchestra conducted by Boyer.
Boyer’s new Rhapsody in Red, White & Blue will be performed in at least 47 states; Boyer and pianist Jeffrey Biegel will record the work with the London Symphony Orchestra for Naxos.
The National Symphony Orchestra performed Boyer’s Celebration Overture as part of its annual Labor Day Weekend Concert at the U.S. Capitol.
Boyer has been commissioned by ORA Singers to compose a new work celebrating the Coronation of King Charles III, to premiere in London on May 3rd.
Boyer’s new Rhapsody in Red, White & Blue, celebrating the centennial of Gershwin’s Rhapsody in Blue, will be premiered by pianist Jeffrey Biegel and the Utah Symphony on June 30th.
The Cleveland Orchestra will give six performances of Boyer’s Ellis Island: The Dream of America at Severance Music Center.
The Boston Symphony Orchestra and conductor Thomas Wilkins gave six performances of Boyer’s Silver Fanfare at historic Symphony Hall.
Peter Boyer conducted the world-renowned London Symphony Orchestra in recording sessions for a new album of his music for Naxos Records.
Boyer will conduct the world-renowned London Symphony Orchestra in recording sessions for the fourth album of his orchestral music, to be released on Naxos Records.


The Environment Agency has begun Somerset Levels dredging on the river as it looks to minimise the risk of a repeat of the heavy flooding that hit the area this winter.
Engineers will work to remove layers of silt that have built up on riverbeds, something that should reduce instances of rivers bursting their banks and flooding surrounding areas.
The Environment Agency said dredging prior to this winter’s floods would not have prevented the damage that occurred, but it is carrying out the work as part of a large-scale plan to safeguard the area.
A five-mile stretch of the rivers Parrett and Tone are first to be dredged, with Craig Woolhouse of the Environment Agency estimated 400,000 tonnes of silt will be removed from rivers in the next six to seven months.
“We’re going to have more machines working in more locations in the coming months to get that work done before next winter and give people more confidence that the sort of flooding they had this year – if we have the same rainfall again – wouldn’t have the same degree of flooding,” he was quoted by the BBC as saying.
Mr Woolhouse added that while it will help reduce the flood risk, dredging is only “part of the answer”, as the Somerset Levels are also influenced by tidal levels, something that are likely to rise as a result of climate change.
This, he explained, is why there are plans to introduce a tidal barrier at Bridgwater and build extra pumping sites, as part of the 20-year Flood Action Plan that would cost £100 million to implement.
The dredging move has been welcomed by Bryony Sadler of the Flooding on the Levels Action Group, who stated it should help significantly reduce the duration of floods. However, she called for further work to also be carried out, such as the construction of the Bridgwater barrier and work on the upper catchment area to slow the flow of water.
Homeowners in vulnerable areas who are worried about the risk of flooding may want to consider taking out insurance for flood risk areas from GSI Insurance Services (Southern) Limited to give them peace of mind.


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Warner Bros. and Turner are pushing their smallscreen content into India in a big way.
Studio will launch WB, a 24-hour Warner-branded channel that will bring its TV and film library to the country beginning March 15. Programming will be licensed from Warner Bros.’ Intl. TV Distribution unit.
The new web is similar to the Latin American Warner Channel, which is linear with no on-demand component. Warner Bros. already has on-demand efforts in Germany, the U.K., Italy and several other territories.
Earlier this week, Turner launched Real, a Hindi general entertainment net.

domain: entertainment


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Green solutions for New York City's overflowing sewers
Techniques such as more trees and porous pavement can reduce runoff that fouls the city's waterways.
(Page 2 of 2)
What does this say about the DEP’s efforts to fulfill their responsibilities?Skip to next paragraph
In Pictures World Water Day 2011
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“Both the testing and the notification that is based on that testing is insufficient. It doesn’t meet their required duties,” Ms. Zidar said.
Zidar is critical of the DEP’s plans for stormwater management as well.
“The DEP is kind of creating their own definition of green infrastructure, which is confusing for people who have been in this field longer than they have,” she said. “They are using the term ‘green infrastructure’ to refer to what’s really stormwater detention.”
Detention refers to a process by which stormwater is held and then later released, decreasing the volume of water in the system. But retention, by contrast, is when water is retained and utilized. Retention, not detention, is what green infrastructure is based on, according to Zidar and others in the S.W.I.M. network.
“There are major flaws in the [city's] plan,” Zidar said. “We’re trying to make this better.”
In addition to the S.W.I.M. coalition, individual sustainability activists are taking matters into their own hands. One technology designer, Leif Percifeld, has invented a way for the NYC sewer system to “talk back” to New Yorkers, alerting them to storm events and system overflows.
Using Open Source coding and software, Mr. Percifeld made a sensor that can detect rising water levels and send text messages warning recipients not to use water at home. His next step is getting into the city’s sewers to install the sensors – no easy task, given that he’s doing it illegally and undercover. With the help of a canoe, a flashlight, and some mapping software, however, he is determined to make it happen. Anyone can sign up for the alerts through the Don’t Flush Me website.
Percifeld is acting to solve this problem as a citizen scientist, tackling a citywide infrastructural problem through grass-roots means: crowdfunding on a website to pay for materials, developing the technology on his own, and entering sewers without authorization.
Another citizen scientist team, Seeing Green, is embarking on a year-long research project to evaluate the potential of urban farms to become part of a city’s green infrastructure. Like Percifeld, Tyler Caruso and Erik Facteau are working at the grass-roots level, collaborating with people in their social network and employing their own know-how and resources to tackle the problem of burdened water systems. Caruso and Facteau would like for their research to nudge city officials into providing further support for urban agriculture.
Cleaning up the city’s waterways is a dirty job. But solutions are evolving from all levels – official citywide plans and grass-roots, collaborative efforts amongst concerned citizens. Moving forward, it will be vital that the lines of communication between all these actors are kept open so that affordable, sustainable solutions can go into effect as quickly as possible.


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A laptop is a personal computer designed for mobile use, as opposed to a desktop computer, which is heavier and usually has a larger screen. Laptops are often smaller than desktops, and typically have a battery that allows them to be used without an external power supply.
A Shortlist Of The Best Laptop For Drawing And Video Editing
Here is a quick recap of our top 10 picks that lets you compare each product with another and allow you to choose the best one.
10 Best Laptop For Drawing And Video Editing People Love In 2022: In Depth Features
- ERGONOMICS: With only 11 buttons and 3 rotary ones, the TourBox comes with over a hundred input methods. At the same time, its compact size and button layout allow full control using one hand. All buttons and knobs are different in shape, and are super easy to be recognized and memorized, so that users don’t have to look down searching for buttons
- PRO AND BEGINNER, obtaining the ideal edit rapidly remains second nature with Loupedeck+'s intuitive buttons, dials and sliders.
- COMPATIBILITY: TourBox works with all Mac and Windows programs that rely on keyboard shortcuts, such as Photoshop CC, Adobe Lightroom Classic, Lightroom, Premiere-edit and Premiere-color, Illustrator, Premiere Pro, DaVinci Resolve, Final Cut Pro X, Clip Studio Paint, Camera Raw, Capture One Pro 21 for MacOS, After Effects, Audition,Capture One Pro, Paint Tool SAI and etc.,
- SETUP: Quick and Easy. We have created some factory fault functions for each supported software, so you can begin editing immediately.Assign your desired shortcuts individually or in combination with any button, wheel or dial according to your workflow and tag them with a unique name at your will. Experience precision video or graphics editing with a simple turn of the knob, or a single or more clicks of the button.
- ONE-YEAR WARRANTY: TOURBOX provides a one-year warranty and lifetime technical support for all our Graphics Tablet Console. Register your TourBox on TourBox official website to apply for service.
- [Battery -free Stylus]---The pen adopts the most advanced passive technology at present, no need to charge or replace the battery, so it's always ready whenever you want to create art,avoiding trouble of battery leakage and low power.
- [8192 Levels Pen Pressure]---The pen features 8192 levels of pressure sensitivity, helps you to draw thicker or thinner lines depending on how hard you push on the pen. It makes lines smoother and more natural, allowing you to capture ideas faster and easier.
- [High Performance]--Working Area:10 x 6.25 inches (255*159mm);Pressure Sensitivity: 8192 levels; Pen Touch Resolution:5080 LPI; Report Rate:233PPS; Sensing Height:10mm
- [1 Touch Ring+1 Round Key+10 Hot-keys]---The touch ring could be programmed for canvas zooming, brush adjusting and page scrolling ( zoom in/out and roll ). The round key designed to shift function among zooming canvas, adjusting brush, and scrolling page. 10 customizable shortcut keys allow more quick access to most commonly used functions.
- [Compatibility]---Windows 7/8/10, Mac 10.12 or later version. And it’s compatible with most drawing program,such as: Photoshop, Krita, Illustrator, SAI2, SketchBookPro, FireAlpaca, OpenCanvas, Manga Studio and so on.
- Create impressive movies and slideshows with this powerful, fun, and feature-packed video editing suite
- Go beyond basic video editing with Ultimate-exclusive video masking, color grading, split screen editing, video stabilization tools, and more
- Explore the powerful collection of tools including MultiCam Capture Lite, screen recording, 360° video editing, audio, stop motion animation, motion tracking, speed effects, and more
- Add style with more than 2000 creative effects and trendy AR Stickers, plus premium effects from NewBlueFX and proDAD
- Export your videos to popular formats to share online, upload directly to YouTube, or burn to disc
- Powerful Productivity: 11th Generation Intel Core i3-1115G4 processor delivers unmatched speed and intelligence, enabling impressive creating, productivity, and gaming experiences. With Turbo Boost Technology, get up to 4.1GHz for your high-demand applications
- Visibly Stunning: Experience sharp details and crisp colors on the 15.6" Full HD display with 82.58% screen-to-body, 16:9 aspect ratio and narrow bezels
- Ergonomic Typing: Ergonomically-designed hinge lifts the keyboard for comfortable typing, improved cooling, and a better sound experience
- Internal Specifications: 4GB DDR4 on-board memory (1 slot available); 128GB NVMe solid-state drive storage (1 hard drive bay available) to store your files and media
- Acer's Purified.Voice technology, features enhanced digital signal processing to cancel out background noise, improve speech accuracy and far-field pickup, which not only makes calls clearer, but makes talking to Alexa easier than before.
- 【Large Active Drawing Space】: UGEE M708 V2 graphic drawing tablet, features 10 x 6 inch large active drawing space with papery texture surface, provides enormous and smooth drawing for your digital artwork creation, offers no-lag sketch, painting experience;
- 【8192 Passive Stylus Technology】: A more affordable passive stylus technology offers 8192 levels of pressure sensitivity allows you to draw accurate lines of any weight and opacity according to the pressure you apply to the pen, sharper line with light pressure and thick line with hard pressure, perfect for artistry design or unique brush effect for photo retouching;
- 【Compatible with Multiple System&Softwares】: Powerful compatibility, tablet for drawing computer, perform well with Windows 10 / 8 / 7 and Mac OS X 10.10 or above; Driver program works with creative software such as Photoshop, Illustrator, Macromedia Flash, Comic Studio, SAI, Infinite Stratos, 3D MAX, Autodesk MAYA, Pixologic ZBrush and more;
- 【Ergonomically Designed Shortcuts】: 8 customizable express keys on the side for short cuts like eraser, zoom in and out, scrolling and undo, provide a lot more for convenience and helps to improve the productivity and efficiency when creating with the drawing tablet;
- ❤Easy to Set Up& Best Customer Service❤: Suits for both right and left hand user with the pen holder and extra pen tips, ideal for professional artist, newbie designer and amateur hobbyist of all kind, provides 12-month hussle free warranty service and clock customer service;
- 50+ brushes and tools (including smudge tool)
- Color adjustment (HSV, brightness & saturation and more)
- Infinite undo and redo (limited by available device storage)
- 7-16 layers with 10 different blending modes and global opacity
- Separate flow and opacity control for brushes
- No assembly required with set-up in less than a minute; Collapses into a thin, portable, and durable portfolio case.
- Measures 25'' x 30'' x 25'' to fit a variety of product sizes; Includes power supply, user manual, and pre-installed removable bright-white backdrop.
- High output built-in LED lights for handheld photography with a camera or smartphone. Lights are positioned for optimum contrast, and provide 5600k daylight balanced LEDs with high Color Rendering Index (CRI) for consistent color. An extra light provides directional light modelling like in a photo studio, giving better highlights, contrast, and shape to product images.
- A front 3-door system maximizes image angles while reducing outside reflections, and a top hole enables imaging from above.
- Compatible with Amazon Seller app; Shoot, edit, and directly upload catalog images to Amazon.
- This everyday laptop is powered by an Intel Celeron N4020 processor, 4GB DDR4 RAM, and 64 GB M.2 PCIe SSD storage
- Enjoy videos or browse online on a 14" HD display panel, framed by narrow bezels
- Dolby Audio delivers crystal-clear sound through the built-in dual stereo speakers
- Light and slim, this Windows 10 laptop computer (S mode) weighs just over 3 lbs and is less than 1 inch thick
- WiFi 802.11 ac and Bluetooth 4.1 connectivity; ports include 2 x USB 3.1 Gen 12 (Type-A), microSD Card Reader; HDMI; Microphone / Earphone Combo
- Create original sketches using your mouse or draw naturally with a pen tablet.
- Powerful coloring tools make CLIP STUDIO PAINT your all-in-one illustration, painting, manga and comic creation solution.
- Use an assortment of powerful art tools for illustrations, comic and manga creation that will help maximize your workflow.
- Download over 10,000 free assets to help get your project started quickly!
- Get $5 credit towards CLIP STUDIO Assets
- 【 Wired Mouse RGB】Wired LED mouse adops interesting rainbow lighting design,which can two buttons to adjust 4 RGB color effects, stylish and beautiful, creating a relaxed atmosphere, perfect for daily work and leisure entertainment at home or on the
- 【Ergonomic Design】The USB Computer Mouse make you enjoy smooth clicking moment. Comfortable Ergonomic claw grip design, no fatigue after long-term work, study and game.
- 【Easy to Use】The USB corded mouse, just plug into the usb iterface,you can get a backlit mouse, very easy to use, no need to use a battery.Side buttons can backward or forward the website
- 【Durability】Adjustable DPI movement enables responsive cursor control for precise tracking, works on most surfaces. Tested over 5 million times keystroke life, the wired mouse ensures responsive click and longer lifespan for daily use.
- 【Wide Compatibility】Our wired computer mice has a wide range of compatibility, Compatible with computer, laptop, desktop, PC, laptop, Windows XP/Vista/7/8/10.We offers you Free Replacement Refund and lifetime customer service,any problems pls contact us via email.
How To Choose The Best Laptop For Drawing And Video Editing
Before choosing a laptop for drawing and video editing, you should take the following considerations into account.
If you’re looking for a powerful and affordable laptop for drawing and video editing, you’ll want to consider the following: 1. Dell Inspason 18x This laptop has a powerful processor and 8GB ofRAM. It’s Heading to the widescreen mode so you can see all the colors together. The graphics are also quite impressive. You can find this model for around $1,000. 2. HP Omen Festera This laptop has a very powerful processor and 16GB of RAM. It’s perfect for artists or those who wants to do a lot of drawing and video editing. The graphics are also quite impressive. It’s around $1,200. 3. Interscope E removable hard drive This is one of the most important thing for any person who wants to have high-resolution pictures and videos on their computer. A hard drive like this one can act as a storage for your pictures and videos or give you some space for other activities like music or books. We don’t know, but if you’re looking for a laptop with a Rondo player, this is it! The Inkscape user manual shows how to add an external hard
Related Frequently Asked Questions
What Is The Best Laptop For Editing Videos And Pictures?
There is no one perfect laptop for editing videos and pictures. However, some laptops you may choose to use for this task include the brand-new Dell Inspirion announce it beats the competition by a lot in terms of battery life and features. discussLaptop has a large screen that is extremely easy to use, including features like adjustable angle View, 3D graphics, and a Core i5-6200U that offers good performance.
Which Laptop Is Best For Digital Art?
dunno. Some people might prefer laptops with a larger screen for more digitalarting opportunities, while others might prefer computers with lower specs for basic work. Ultimately, either of these devices can be great for digital art work-updates and storage for various projects.
What Laptops Do Video Editors Use?
Some video editors use laptops for work and for video editing. Other videos editors use laptops for school or personal use.
What Laptop Do Artists Use?
An artist’s laptop is the one they use to work on their work.
The best laptop for drawing and video editing can be summarised as being designed primarily for that purpose. This means that the laptop will have a number of features which are also found on other high-end models, such as a powerful processor, good graphics card, and good memory. These factors will help make your work looked by comparison.

domain: artistic


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What do you really know about the Zika virus? Well, if you’re like the folks that Harvard School of Public Health recently asked…not much.
The Harvard researchers polled over 1,000 American adults — including 105 people living in households where someone is pregnant or considering pregnancy — and found some gaping awareness about the spreading virus.
So to freshen up your Zika knowledge, we clarify some of the biggest misconceptions.
Is There a Link Between Zika Virus and Birth Defect?
Approximately one in four people that Harvard polled is not aware of the association between Zika virus and the birth defect microcephaly.
Microcephaly is, in fact, one of the biggest concerns. Evidence is mounting that Zika infection in any stage of pregnancy may be causing microcephaly, a condition that results in abnormally small heads and underdeveloped brain in babies. Zika infection in pregnant women has also now been associated with other birth defects such as eye problems, hearing loss and impaired growth.
Is There a Vaccine for Zika?
Twenty percent surveyed in the Harvard poll mistakenly believe there is a vaccine to protect against the virus.
There is currently no vaccine to protect against Zika. According to the National Institute of Allergy and Infectious Diseases, there probably won’t be a Zika vaccine that is widely available, safe and effective for the next few years.
The good news, though, is that public health officials expect the first human trials of a Zika vaccine to begin this year.
How is Zika Transmitted?
According to the Harvard poll:
- 42 percent do not realize Zika virus can be sexually transmitted
- 31 percent mistakenly believe Zika virus is transmitted by coughing and sneezing
- 29 percent are unaware it can be transmitted through blood transfusions
Zika virus is mainly spread by mosquitoes, primarily the Aedes aegypti mosquito. But Zika can also be sexually transmitted. In fact, the virus can be detected in semen longer than it is found in blood.
The CDC recently advised couples who have been exposed to Zika to delay pregnancy. The most striking guideline was for men who have been exposed to the virus: they should use a condom or abstain from sex for at least 6 months.
According to the CDC, Zika virus may also be transmitted through blood transfusions. That’s why the American Association of Blood Banks recently issued guidance to travelers returning from areas with Zika: Don’t donate blood for 28 days.
Zika is not known to be spread by coughing and sneezing.
If I have Zika, I'll Have Symptoms
At least 25 percent of adults in the Harvard research think infected individuals are "very likely" to show symptoms.
In fact, doctors largely ignored Zika at first in South America because the virus usually causes mild to no symptoms. One study suggests about 80 percent of people who are infected don't even know they have the disease, while the other 20 percent mostly suffer just a rash, mild fever and headache.
Link to Nerve Disease
Nearly three-quarters of the people polled are unaware of a link between Zika virus and Guillain-Barré syndrome (GBS), which can cause paralysis.
The CDC is quite concerned about GBS and is actively investigating the link between Zika and this neurological disorder. The World Health Organization considers this association between the virus and the paralysis affecting seemingly healthy adults "alarming".
GBS symptoms include arm and leg weakness, facial paralysis and problems with swallowing. These symptoms can last anywhere from a few weeks to several months, or longer.
The nationally representative poll was conducted by telephone, March 2-8.

domain: medical


text:
The startup plans to use the funds to expand its team. There are also plans to integrate more deal analytics and artificial intelligence into its platform. Further creation of a credible international network of B2B sellers and buyers is in the pipeline.
Co-founder and Chief Executive of Aligned Gal Aga said, “These modern times present a game-changing opportunity to do what companies like Slack and Zoom did to the way we connect, which in the case of Aligned, is to make buying and selling more impactful for both sides, even enjoyable. We’re passionate about leading this change to make the B2B buying and selling experience frictionless, collaborative, and streamlined.”
In order to promote easier collaboration, facilitate business relationships, and speed up the deal pipeline process. Aligned is building a network for B2B buying and selling. It facilitates deal-making by providing online “rooms” where sellers and buyers can collaborate on shared resources, schedule follow-up meetings and deadlines, and communicate, create and sign proposals. Aligned also generates insights to aid sellers in making wise decisions by examining interaction data and stakeholder intent signals.
According to the startup, 77 per cent of buyers complain that B2B purchase is too difficult. However, buying is getting more complex due to the availability of large amounts of information to choose from. Customers who experience a high degree of ease of purchase are three times more likely to buy a bigger deal.
The offering is helping businesses reduce the back and forth in the buying and selling process. Its mission is to elevate how sales teams and their customers work together which makes business smooth, more enjoyable, and productive.


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Our company bears social responsibility. Aiming at reducing the potential environmental burden and impacts caused by our products, we make a life cycle assessment part of the development of sustainable new products.


PARIS — Satellite communications is among the most-favored categories in the U.S. Defense Department budget proposal as the U.S. repositions its military spending away from asymmetric threats, Kratos Defense and Security Solutions Chief Executive Eric M. DeMarco said.
The uplift in military satcom spending, combined with Kratos’ position in tactical and target drones, is one of the reasons DeMarco is telling investors that the company is in for sharp growth in revenue and profit.
Recent years’ focus on internal research and development spending to accumulate intellectual property . . .
To view the entire article, become a subscriber!


Coast Hwy 101
Oceanside’s main drag, North Coast Hwy 101, seems to go on forever, stretching from Vista Way to Harbor Drive.
Traveling along Oceanside’s downtown Hwy 101 is surely an adventure, as if going in a timewarp back to the fifties and sixties. Much seems to be as it was back then, with an ecclectic mix of mom and pop shops, restaurants and old cafes, thrift shops, army and navy stores, beauty salons, office buildings, surf and watersports shops, florists shops, liquor stores, and more.
Downtown Oceanside has seen seedy days, when it was a place you wanted to avoid. Now, it’s cleaner than it use to be, with many restored exteriors and newly painted murals and faces.
The main street is lined with palm trees and sidewalks. You could walk from one end of town to the other, along long blocks, punctuated by cross streets that go the ocean, a few blocks away.
Notable Downtown Attractions
The heart of downtown Oceanside, around Hwy 101 and Pier View Way, has some notable attractions, including the California Surf Museum, The Oceanside Museum of Art, the 16 screen Regal Theaters, and the recently built Civic Center and Library. Downtown Oceanside is about four blocks from the beach and Oceanside Pier.
Many of Oceanside’s outdoor events, including holiday parades, street faire, and farmers’ markets take place in this part of town.


Gangnam NightlifeFri Oct 14th 2016 at 22:00
Club Octagon , B1/B2 New Hilltop Hotel, 152 Nonhyeon-dong, Gangnam-gu, Seoul , Nonhyeon-dong http://www.mydestinationseoul.com/events/diego-miranda
The most influential and talented DJ in Portugal, Diego Mirada!
He has been awarded with many rewards including the MTV Europe Music for Best Portugese Act.
His music is only available in Octagon!
Enjoy his show for the first time in Korea!


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And has been reported in SFWA, Kelly Freas has passed away. For those who don't know, Kelly Freas was the artist who illustrated so many of the SF magazine covers (Analog, Astounding, Azimov's, and so on) for decades, as well as doing the covers to the Writers of the Future first-time-writer anthologies. Right up until he passed away, he was still taking commissions, and still filling those roles. He was perhaps the most prolific SF and Fantasy cover artist out there, and it's always been considered a real honor to get your story illustrated by him.
A new year brings new beginnings, but I suppose some new endings as well.

domain: literature


text:
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Chris is still on pre-move vacation so we used Monday to get one of my last National Park Passport stamps in the southeast region: Fort Matanzas! This is that one south of St. Augustine we tried to go to right after non-hurricane Fay when it was closed. Before we even get to the monument we see a big, fat spider.
Yikes! The ferry to the fort wasn’t running, but who cares, they’re all starting to look alike to me anyway. I mean, “this is the French fort for fighting the Spanish,” “This is the Spanish fort for fighting the British,” “This is the British fort for fighting the Spanish,” and “No surprise no one was building forts against the French, because this is the fort where they were all killed because of the lack of fresh, gourmet food available during the winter.” And that’s the one here:
Well, let’s go on the half-mile nature walk! I suggested. Chris was non-plussed. It was a nice, short walk through Floridian underbrush, and oh, were there spiders….The spiders were not alone; I’ve seen these rainbow salamanders all across Florida but can’t figure out what they’re called. And a duo of stick bugs. We were out of time to go to the beach, so we got Floridian Christmas ornaments in St. Augustine instead and had coffee and cupcakes at Luli’s Cupcakes. Of course I had the pumpkin one—Monday was its first day as flavor of the month! Poor Chris; I looked across the tiny pink table and he’s sitting in this tiny blue chair in a pink room under a lamp made of paper cupcake holders. He’d already devoured his cupcake and was sweetly suffering through the pinkness while I finished my coffee. I am married to the most gracious man in the world. 🙂

domain: geography


text:
I had a conversation today in which I confessed my love-hate relationship with the BBC. On the one hand their professionalism is sans pareil. They make lots of good programmes. But there are increasingly few (do I mean decreasingly many?) which illuminate the many desperate problems which face us. And I think they do this on purpose.
For the umpteenth time this evening I sat slack-jawed in front of Newsnight. I am not as bright as a citizen should be – as we need all citizens to be. But I spend hours every week reading and listening to economists.
I would suppose that makes me more acquainted with economics than most of my fellow voters. If I challenged you to name four Nobel Prize winners in Economics, or the most influential academic economist of the late twentieth century, or the dominant economic school in the western world, how would you do? I sorta know who the players are. I sorta know what the broad brush differences are. I know that Samuelson was an idiot. He predicted that the Soviet Union would bury the West. He wondered whether the gulag was worth the shortage of toilet paper (or was it vice versa?)
I am a crappy economist. I sorta struggle with Sey’s Law – probably spelt his name wrong. I get von Mises critique of socialist price theory – there is no such thing. But I know more Economics than anybody in my street, perhaps than anybody in Stretford.
When it comes to the Maths of Economics I am pretty well totally at sea.
So, at 20:35 we have Jeremy Paxman interviewing a Rothschild and a few others. Did I expect to be illuminated? I did not. Was I? I was not.
There exists a phenomenon which I have mentioned in earlier posts. It is called fractional reserve banking. This is rather difficult to understand – not just because it is complicated (it is), but that it turns out to be legal.
They way banking is supposed to work and the way it did work initially was as follows:
Mr A decided not to spend his substance on “goodies” but to save money instead. He chose to invest the cash in a bank. The bank promised to invest his money in a promising business which would pay interest on the investment. They further agreed to share the interest with Mr A.
Nothing could be fairer.
The bank, though, offered his money not to “a promising business” but to 33 “promising” (all of it, not just one thirty-third) businesses, nearly all the money to all of them, all of which would pay interest on what you and I think of Mr A’s money. Bankers make money umpteen times over on Mt A’s decision not to buy “goodies”.
Is this something that Newsnight shares with you when explaining problems with the banking system? It is not!
I share with you not my economic sophistication but my rage with those who would ignore common sense. You can’t make money (or increase wealth) by doing arithmetic. The only way you can increase wealth is by increasing production. There are those who think that increasing demand is the answer. This is stupid. Demand is already and always will be infinite.
Was fractional reserve banking mentioned? Not before I switched Newsnight off. Ask anybody you know what fractional reserve banking is.
It is pure legal theft. It's theft, in the same way that deliberate government cash creation is theft.

domain: finance


text:
PROTOTYPE CARTOONS | CARTOONIST PROTOTYPES
Prototypical cartooning is something I did not aspire to be. Although I found myself following that path.
As a young kid, I loved drawing and creating goofy looking cartoons.
I found lots of cool magazines in the school library that ran cartoons like Boys’ Life magazine, National Review and of course The New Yorker.
I was awestruck by a lot of the cartoons published throughout the New Yorker alone, at that time.
So many in there were more like masterpieces. Like the work of Charles Addams. His drawing style did lend itself well for architectural design and the indoors scenes in his cartoons were nothing less than elegant.
Developing prototypes of favorite cartoonist’s works
I leafed through stacks of old magazines and his cartoons appeared throughout many previous issues on a regular basis as did many other cartoonists whose work I enjoyed.
I would sketch with pencils in a freehand cartooning style, after studying these master’s line work.
I would grab a dip pen and get the nib full of Higgin’s waterproof India Ink and also sketch in another type of freehand style.
I didn’t realize what I was doing at the time was emulating cartoons I appreciated, in a prototypical cartooning type of drawing style. Am I complaining? No.
Cartoon drawing styles take time to develop
I think creating cartoons in this manner helped me to refine a drawing style I was getting used to, and at the same time, familiarizing myself with the various cartooning tools at hand.
In a certain sense, no matter what path you choose in order to become a cartoonist, sketching existing cartoons and styles of cartoonists whose work appeals to you can help you refine and develop your cartoons over a period of years.
Although creating prototypes is good, don’t necessarily copy or duplicate an existing style.
Use various nuances and incorporate those into the ways you develop your cartoon style.
You’ll soon realize how much fun cartooning can be and how rewarding it is.


text:
Modeling HCV disease in animals: Virology, immunology and pathogenesis of HCV and GBV-B infections
Hepatitis C virus (HCV) infection has become a global public health burden costing billions of dollars in health care annually. Even with rapidly advancing scientific technologies this disease still poses a significant threat due to a lack of vaccines and affordable treatment options. The immune correlates of protection and predisposing factors toward chronicity remain major obstacles to development of HCV vaccines and immunotherapeutics due, at least in part, to lack of a tangible infection animal model. This review discusses the currently available animal models for HCV disease with a primary focus on GB virus B (GBV-B) infection of New World primates that recapitulates the dual Hepacivirus phenotypes of acute viral clearance and chronic pathologic disease. HCV and GBV-B are also closely phylogenetically related and advances in characterization of the immune systems of New World primates have already led to the use of this model for drug testing and vaccine trials. Herein, we discuss the benefits and caveats of the GBV-B infection model and discuss potential avenues for future development of novel vaccines and immunotherapies. Hepatitis C virus (HCV) is a major chronic disease that has infected greater than 150 million people worldwide. Given the breadth and duration of infection HCV disease could result in an economic crisis reaching into the 100s of billions within the next decade. Although acute infection is usually asymptomatic with self-resolution, 55-85% of infected persons develop chronic disease that can lead to progressive hepatic fibrosis, cirrhosis, and hepatocellular carcinoma (HCC; Hoofnagle, 2002) which is often fatal without treatment. There is also a strong association of HCV infection with extra-hepatic diseases such as cryoglobulinemia vasculitis (Luppi et al., 1998), diabetes (Mehta et al., 2000), thyroid disease (Pateron et al., 1992), lichen planus (Jubert et al., 1994), and neuropsychiatric conditions such as depression (Thomas, 2013). This is complicated by the fact that approximately only half of individuals are aware of their HCV status (Denniston et al., 2012), due, at least in part, to the rarity of symptoms in acute HCV infection. In 2007, mortality due to HCV infection surpassed that of HIV in the United States (Ly et al., 2012).
Manickam, C; Keith Reeves, R
Volume / Issue
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)


text:
In-home services prioritize family preservation and include community-based and family-focused interventions that aim to keep children safely in their homes. This month's CBX highlights a new book centered on the Homebuilder's model, an in-home intervention that provides families with counseling, life skills education, and other tools geared toward family preservation; an article that describes an evaluation of the Boys Town In-Home Family Services model; an article that discusses whether a referral to family group conferencing was associated with improved outcomes for families involved with child welfare; and a study that focuses on the differences in child well-being among children investigated for maltreatment who remained at home with a substance-using caregiver compared with children investigated for maltreatment without a substance-using caregiver in the home.
- Intensive Family Preservation in Human Services
- Well-Being Outcomes and Co-Occurring Parental Substance Use Following a Maltreatment Investigation
- Evaluation of Boys Town In-Home Family Services With Families Referred by Child Welfare
- Evaluation of Family Group Conferencing and Its Effects on Rereferrals and Out-of-Home Placements
Spotlight on National Adoption Month
Spotlight on Youth Homelessness
News From the Children's Bureau
We highlight the 2016 Adoption Savings report, which compiles data from state and tribal title IV-E agencies' reported adoption savings as well as background information on adoption savings requirements; a new six-part video series covering the National Youth in Transition Database (NYTD) and the NYTD Review; the newly released Child Maltreatment 2016 report; and a list of the latest updates to the Children's Bureau website.
Read a report that aims to evaluate and understand integrated approaches for simultaneously improving family self-sufficiency and child well-being by examining existing programs and research needs, a survey of state independent living coordinators that offers a detailed look at the services and supports provided to young people transitioning from foster care, and a report that focuses on the Educating Fathers for Empowering Children Tomorrow program and its effort to improve children's well-being through helping fathers become more involved and educated and increasing protective factors by investing in fatherhood programs across the state.
This section of CBX offers publications, articles, reports, toolkits, and other resources that provide either evidence-based strategies or other concrete help to child welfare and related professionals.
This section of CBX provides a quick list of interesting resources, such as websites, videos, journals, funding or scholarship opportunities, or other materials that can be used in the field or with families.

domain: sociology


text:
Near (NEAR), a new Ethereum rival, is surging in value following the completion of a new funding round.
From a low of $13.38 on Monday, the altcoin surged to a high of $19.92 on Thursday on news that the Near Foundation had raised an additional $150 million in investments.
Su Zhu, CEO of Three Arrows Capital, tweets about the financing round to his 456,400 followers, disclosing that the cryptocurrency hedge fund spearheaded the private token sale.
Mechanism Capital, Dragonfly Capital, Andreessen Horowitz, Jump, Alameda, Zee Prime, and Amber Group are among those who have invested in cryptocurrency funds.
The Near protocol is a decentralized application platform and proof-of-stake blockchain that employs sharding technology. The Ethereum competitor is a relative newcomer to the crypto industry, but investors and experts alike are optimistic about the digital asset.
According to Su, macro investors are clinging on to bitcoin while exiting other holdings when the market corrects. Meanwhile, Cantering Clark, a pseudonymous crypto expert, predicts that the cryptocurrency will increase past $20 and perhaps reach $50.
NEAR is now trading at $19.32 at the time of writing.


text: Some years back I remember hearing a song on the radio, it was catchy and retro just up my alley like the radio station in my town liked to play it was called "Tell me your secrets" by Radio Chaos, I thought it was cool so I wrote it down in a list of songs to add my collection that I did at that time, just yesterday I came across the old list and realized that song was not crossed off, curious as to what it was I looked into it.. and HOLY CRAP. no wonder I couldn't find it to add to my collection, this band is pretty much non existent. upon searching what I found was a page that listed 29 second tracks of all the songs (including that one) on a compilation album called 'Rocktoria 3 (1991)' it was listed on a site called 'royal city music project'. curious as to what Rocktoria 3 was, I dug a bit deeper, apparently its an annual battle of bands like contest that a local radio station by the name of 'Q 100.3' in Victoria, bc, Canada puts onto a compilation disc, doing some more research they were still doing these well into the 2000s coming up with titles like 'Rocktoria 9' and 10. I even found a website listing them all and all their tracks aside from rocktoria 3.. the trail pretty much ends here, theres a bit more info on rocktoria the first one, and one of the artists 'Playground Hero' had a few songs of theirs uploaded to yt, but as for Radio chaos, and the other artists off the 'Rocktoria 3' wich include names like 'Purple City', 'Jho Nek Jhone', and 'Monica Schraefel' these artists are NO where to be found anywhere, its like they don't exist. no wiki, no artist webpage, no audio files on any free mp3 downloads place, nothing on youtube, nothing. this could be, the RAREST music I ever stumbled across!

domain: hobby


text:
Transference – Chapter 7 – The Confrontation – by lostandwhatever
- Age Progression
- Age Switch
- Stories filter
- User Story - Age Progression
- User Story - AR & AP
- User Story – Other
Continued from Chapter 6.
Mark drove home and struggled to keep his eyes on the road. He kept checking the clock on the dashboard. It read 10:54 p.m. A minute ago it had read 10:53. Soon he would check again and again until it read 10:55. He tapped a finger on the steering wheel with no regular rhythm. He was working out energy that felt like it would burst out of him.
What was happening at home? he thought again and again.
The last two texts he had sent home had gone unanswered. That could mean several things. It might be that they had started the program and entered the machine, and so they might be finishing up their transference right now. Or, it might be that it all had gone wrong somehow. Maybe he had miscalculated. Maybe the program was faulty or the repairs had failed, and they would return home to find the two of them locked in their chambers in some state of unconsciousness, minds confused, mentally lost to the world. That would be the end of the game. There would be no hiding it from Melissa then. He would have to take drastic measures. He might be able to use the unconsciousness beam weapon on her to keep her incapacitated while he sorted things out. That would be hard to explain, though. He would have to fiddle with Melissa’s memories in that case, which might only make things worse, and things were bad enough already.
He should have been there, he decided. He should have found a way to be there in person for the transference. It would have been safer. Now, he had to face the truth: he was a coward. He could admit it to himself: a coward. He was too scared to do it himself. Now, there was this uncertainty. Possibly there was a disaster waiting for him at home. He should have found the guts to actually do it himself.
“I really liked that movie. Didn’t you?” his wife asked.
If you had tortured him, he could not have told you the name of the movie they had seen or even what the movie was about. He could not focus on the film at all. His mind kept retreating back to his home and what might be happening there. “Yes,” he said. “It was good.”
“Are you feeling alright?” Melissa asked him.
“What?” he said. “What do you mean?”
“Oh,” he said and wiped his brow dry on his sleeve. “I don’t know. Maybe I’m coming down sick or something.”
“Well, we’ll be home soon. You can get some rest then,” Melissa said. “Just take it easy until get there. You’re speeding a bit.”
He let the car slow down and tried to calm himself. “Right,” he said. “I’m fine. Everything’s fine. Don’t worry.”
“I’m not w-”
“We’re all good. Nothing to worry about. No problems.” He tapped his whole hand on the steering wheel now.
He could feel her giving him a suspicious look, so he tried to act natural and held the wheel with both hands firmly.
They rounded a corner, and there was their home. Nothing appeared to be wrong from the street. Although if something had gone wrong, then there would be no sign of it outside, unless, of course, things had gone catastrophically wrong.
Mark opened the garage door and parked the car. They got out, shut the garage door, and entered the house. Mark tried to prepare himself for the worst.
The babysitter was sitting alone at the kitchen table, reading something on her cell phone.
Mark saw her and was relieved for a moment until he realized he did not know who he was looking at right now. Was it his partner, Julie, or his daughter, Katie?
“Hello, Julie,” his wife said. “I take it that Katie is sleeping.”
The babysitter looked up from her phone and smiled at Mark and his wife. “Hi there!” she said in a chipper voice. “Welcome back! Yeah, Katie is sleeping in her crib. She’s all tuckered out.”
“Did you have any problems?” his wife asked.
“None at all,” the babysitter said. “Everything went exactly to plan.” She looked at Mark and gave him a slight wink.
He breathed a sigh of relief. This had to be Julie. He had been worrying over nothing. Everything had gone perfectly. Why had he doubted himself? Of course it had all worked out.
“Good to hear,” his wife said and took off her jacket. “Mark, could hang this up for me, please? I’m going to pay Julie her money.”
“Um, sure,” he said. He took her jacket and headed for the closet with a faint smile on his lips. The nightmare was finally over.
The women followed him into the front room of the house. Then, Melissa dug out some twenties from her purse and handed them to the babysitter. “That should be enough. Right?”
“Oh, that’s plenty,” she said as Mark finished hanging up their jackets. “Thank you,” she said. “It’s been a quite an evening, but I guess I should be going, now.”
“Goodnight,” Mark said. “And, thank you. I’ll see you later.”
“Yes,” his wife said. “Thank you.”
“Yeah,” the babysitter said and then she paused when her fingers touched the doorknob. “Actually, I did have a couple of things I needed to tell you, Mrs. Smith.”
Mark frowned. “What?” he said.
The babysitter walked past Mark close enough to brush her fingers gently against his chest. Then, she headed over to their couch and sat down in the middle of it by herself. She crossed her legs and spread her arms wide on the top of the couch behind her.
“First,” she said to his wife. “I have a bit of a confession… or a revelation… about you husband.”
Mark cursed under his breath. What was she doing?
“What about my husband?” his wife asked.
“He’s been doing some things behind your back that you’re not aware of.”
“What do you mean?”
Mark felt himself start to sweat again. What the hell was she doing? Was this really Katie? What was she about to tell his wife? He glanced towards the box in which he hid his unconscious beam weapon. He needed to act fast before she said anything. “Julie,” he said as he backed away towards the box. “Hold on a second.”
She ignored him and kept talking, “Mrs. Smith, your husband has been having an affair… with me. Well, not really me, just this body. I’m not really me. I’m actually Katie… or I was. It’s a bit confusing, you see.”
Mark’s fingers touched the box. Without looking at it, he opened it up.
“That’s the second thing. You’re husband has been downstairs playing around with his machine, swapping his daughter and mistress’ minds.”
His wife said, “What are you talking about? What is this? Mark?” She turned to her husband.
Mark’s hand was inside the box fishing around for the unconsciousness beam weapon, but he could not find it in there. The weapon was missing.
“Looking for this?” Katie said. Mark and his wife turned to see her pull the weapon out from behind a pillow on the couch. She aimed it at them and rested a finger on the trigger. “Hands up where I can see them, please.”
Mark held his hands up.
“What the hell is going on?” his wife asked. She raised her hands as well when she saw Mark had his hands up. “What is that thing?”
“It’s a stun gun,” Katie said. “Though, Mark called it an ‘unconsciousness beam’ in his notes.” She pointed it at him. “Seriously? That’s what you came up with for a name?”
“How did you find that?” he asked.
“Well, it was in your favorite little box where you like to hide all of your secret toys. I guess Julie knew about the box, so now I know about it as well.” She smiled. “I know about so much now.”
Mark’s mind raced as he tried to think of a way to stop her. He realized he was mostly out of options now.
“Sit down,” Katie said as she waved the gun at the two other chairs in the room.
His confused and frightened wife followed the command and kept her hands raised as she sat on a chair.
But, Mark did not move. “Why?” he asked. “Why do we need to sit?”
“I don’t want you to hit your head when you pass out,” Katie said.
Mark made a desperate lunge for the weapon that caught Katie off guard, but she was too far away for him to reach her before she pulled the trigger.
There was a momentary hum. Then, Mark felt his body go limp, and he dropped to the floor, landing painfully on his face. He heard his wife cry, “Mark!” as his mind was dimming away. Then, the weapon hummed again, and his wife was silent. Then, everything went silent and dark.


Adjustable Wheel Storage Rack by Auto Dolly®. The product is designed for easy and safe off-floor storage of tires and wheels of any size. Thanks to its chain link selection, the item can be adjusted to the size you need and simply folded back against a wall of your garage or shop when not in use.
- Created to store wheels and tires of any size
- Frees up floor space
- 48" width between mounting holes
- 24" height
- Made of strong steel
- Red painted finish
- Chain links and 'S' hooks adjust the depth
- Maximum depth is 24"
- Supports up to 400 lbs.
- 46" storage bar width
- Mounting holes fit on 16-inch center studs
- Folds flat against a wall when not in use
- Covered by a limited lifetime warranty
- Made in the USA
A clean and well-organized garage makes everyone feel happy. When it comes to perfect order there, wheels and tires stored on the floor will upset the apple cart. This product is what the doctor ordered to get wheels and tires up off the floor. The equipment allows for safe and easy off-floor storage of wheels and tires of any size thanks to its adjustable chain link selection and 'S' hooks. The maximum depth of the item is 24'' that is adequate for supporting 12-18'' mounted tires. Made of extra strong steel, this rack can support up to 400 lbs. Moreover, the product can be folded flat against a wall when not in use, thus saving space in your showroom, garage, restoration shop, and so on. Proudly made in the USA, this tried and tested item is backed by a limited lifetime warranty to withstand the test of time.
The company was originally founded by Jim Merrick in 1961. It was established to manufacture a new line of highly automated and specialized machinery for home builders. The company having proved extremely successful, began a diversification program into the plastic business in 1972. As the company grew and developed it was incorporated into various divisions.


text:
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A myc tag is a polypeptide protein tag derived from the c-myc gene product that can be added to a protein using recombinant DNA technology. It can be used for affinity chromatography, then used to separate recombinant, overexpressed protein from wild type protein expressed by the host organism. It can also be used in the isolation of protein complexes with multiple subunits.
A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.
The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.
|Human LAMP2 ORF mammalian expression plasmid, C-GFPSpark tag||HG13555-ACG|
|Human LAMP2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG13555-ACR|
|Human LAMP2 ORF mammalian expression plasmid, C-Flag tag||HG13555-CF|
|Human LAMP2 ORF mammalian expression plasmid, C-His tag||HG13555-CH|
|Human LAMP2 ORF mammalian expression plasmid, C-Myc tag||HG13555-CM|
|Human LAMP2 ORF mammalian expression plasmid, C-HA tag||HG13555-CY|
|Human LAMP2 Gene cDNA clone plasmid||HG13555-G|
|Human LAMP2 ORF mammalian expression plasmid, N-Flag tag||HG13555-NF|
|Human LAMP2 ORF mammalian expression plasmid, N-His tag||HG13555-NH|
|Human LAMP2 ORF mammalian expression plasmid, N-Myc tag||HG13555-NM|
|Human LAMP2 ORF mammalian expression plasmid, N-HA tag||HG13555-NY|
|Human LAMP2 natural ORF mammalian expression plasmid||HG13555-UT|
|Узнайте больше о векторов экспрессии,|
LAMP2 (Lysosomal-associated membrane protein 2), also known as CD107b (Cluster of Differentiation 107b), is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. In human, LAMP2, the causative gene of Danon disease, located on chromosome Xq24, encodes the lysosome-associated membrane protein-2 (LAMP-2). LAMP-2 deficiency, or Danon disease, is a rare X-linked lysosomal disease characterized by cardiomyopathy, vacuolar myopathy, and mental retardation. LAMP2 cardiomyopathy is an X-linked and highly progressive myocardial storage disorder associated with diminished survival, which clinically resembles sarcomeric hypertrophic cardiomyopathy.


text:
Paramedic - ER*
The Paramedic in theEmergency Department at Northwest Medical Center Provides advanced life supportcare to patients who are ill and/or injured. Transports and transfers patientsand assesses the extent of an illness or injury to establish and prioritizemedical procedures to follow. Applies artificial respiration or administersoxygen in cases of suffocation and asphyxiation, dispenses antiseptic solutionto prevent infection, starts and administers intravenous fluids, and performsother emergency medical procedures during the ambulance ride.
Carries outtherapeutic measures for patients in the Emergency Department while workingwith the emergency team as directed by the Administrative Medical Director oronline qualified physician (per R9-25-204, 205), and ED NursingLeadership.
Shifts are scheduledfor 12 hours and additional hours and shifts are possible per the needs of thedepartment.
High Schooldiploma/GED preferred or equivalent experience required.
Post High SchoolVocational/SpecializedTraining.
One year experiencein a pre-hospital setting, 2-4 years of related experiencepreferred
Perform Medicaltreatments, procedures, Familiar with standard concepts, practices, andprocedures within a particularfield.
AZ state CEPcertification
BLS, PALS and ACLScertification - Must beAmerican Heart Association


text:
Reviews of Chabrol Apartment
Calle Primavera, nº 3, Madrid
Lawrence Luke Mastin, 53
Facilities provided were generally fine, but a few smaller things (that travellers may not have) might have been nice, e.g tea towel, soap, etc
Marlies Sneller, 52
we had a wonderful time, the apartment was very nice and located in a beautiful neighbourhood. At night the garbidgemen made a lot of noice, but only for a short time. It was a pity we could not store our luggage in the apartment while our plane left in the evening.

domain: travel


text:
With the history of casting animals in prominent roles in the films, Bollywood has tweaked the saying “Dogs are men’s bestfriends” just a little bit. More often than not, we have seen tigers as a very important part of a movie. So, as the world celebrates it’s 11th International Tiger day, here are some movies that have the wild cats in a prominent role!
This film is a action thriller that tells us the story of a forest service officer trying to capture a distressed tigress. It highlights topics like conflict between humans and wildlife and wildlife conservation.
The film is about a the spirit of a local tour guide who was thrown to feed tigers by a mob of villagers tries to protect the jungle in his own twisted way. By offering, astray tourists the same fate he was offered.
The film narrates the story of Ravi who comed back to his homeland to find his family in a deplorable state. But aside from that the scene that attracted most audience was the one where Ravi fights tiger to save his villagers.
A little different than mainstream cinema, this film is about the protagonist turning into a tiger every full moon. The cycle starts when he is attacked by a cursed tiger one night.
Khoon Pasina (1977)
This is a story two rivals having a massive face off. But the scene that gained the more traction was one where Amitabh Bachchan’s character fights a real tiger on screen to save Rekha’s character from being attacked.
Mr. Natwarlal (1979)
This is a story about how a bandit uses a tiger to scare the people of a village in order to capture it. That’s when Natwarlal who is played by Bachchan puts up a brave fight to save the villagers.
Roar: Tigers of the Sundarbans (2014)
In this film the saying hunter becomes the hunted comes literal when a group of commandos try to capture a white tigress after she kills a man. When the tigress naturally overpowers them and things go sideways.
(Contributed by Prachi Mogal)


text:
You might be one of the lucky ones; your dog might maintain gorgeous white teeth without any effort on your part whatsoever. Just wait, though. Sooner or later, all dogs can benefit from having their teeth brushed. Plaque and tartar accumulate on canine teeth just like ours. Plaque is made of proteins from saliva, which interact with bacteria. If left to accumulate on teeth, bacteria quickly multiply and can invade the gums around the teeth, causing inflammation known as gingivitis. If plaque is not removed, inflammation of the gums can spread to the bone around the teeth, leading in turn to bone loss or periodontal disease.
At some time or another, every dog lover has endured a blast of bad breath from an ardent canine companion. Foul-smelling breath is so prevalent among pooches that the very phrase has come to be an insult, as in, Get lost
12Page 2 of 2

domain: pet


text:
Decided against following a sketch, just wanted to have a little play.
The stamped image I cheated, I printed off one from google then coloured it in with my sons pencil crayons (yes I know I should be using pens but I didn't want the expense of something I may not be able to get on with!)
The papers were kindly given to me by a lady called Melissa (only just started to use them! Thankyou!) the flowers arrived safely this morning and the brad I already had. First time I have ever used scallop cards, brads and stamped images, so a completely new card from me today :)


text:
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6409 Park Ave, West New York, NJ 07093 • Delivery Info
Online ordering is not available for today!
Minced Pork and Shrimp Paste in Spice Szechuan Bean Sauce Over a Bed of Lo Mein Noodle
Jumbo Shrimp, Chicken, Beef, Broccoli, Snow Peas, Baby Corn & Bamboo Shoots in Garlic Sauce
Jumbo Shrimp, Chicken, Broccoli & w. Mixed Vegetables
A Combination of Shrimp, Beef, Chicken, Roast Pork Sauteed w. Vegs. in Brown Sauce
Jumbo Shrimp, General Tso's Chicken Sauteed with Chinese Vegetable in Chef's Special Sauce
Crispy duck with Mixed Vegetables in a Chef's Special Sauce
Beef & Jumbo Shrimp with Chili Pepper in a Rich Hot Spicy Sauce
Chicken, Beef, Shrimp w. Hunan Sauce
Sauteed Sliced Chicken and Vegetable in a Spicy Thai Sauce
Sauteed Sliced Beef and Vegetable in a Spicy Thai sauce
A Great Variety of Green Veg., Broccoli, String Bean & Snow Peas
A Combination of White Meat Chicken & Jumbo Shrimp, Broccoli, Mushroom & Baby Corn
A Combination of Roast Pork, Shrimp, Chicken & Beef w. String Bean, Celery, Broccoli, Carrot & Chinese Vegetable
A Galaxy of Fresh Sea Scallop, Crab Meat, Lobster & Prawn w. Variety of Green Vegetable
Jumbo Shrimp, Scallops, Chicken & Beef Slices w. Snow Peas, Broccoli & Baby Corn
Lobster Meat, Crab Meat, Jumbo Shrimp, Scallops, Beef, Chicken, Roast Pork Sauteed w. Mixed Vegetable
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