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Bringing Silicon Valley financing to Greater Washington
- Bryant Ruiz Switzky
- Senior Staff Reporter- Washington Business Journal
When it comes to lending to tech startups, Silicon Valley Bank has an impressive grip on the market. The Santa Clara, Calif.-based institution has been in the D.C. area 15 years and claims half of the region's venture-backed companies as its clients. The bank, which has $21.5 billion in assets, has grown its Tysons Corner team by 25 percent in the past year to 10 people. I caught up with Megan Scheffel, who manages the bank's Mid-Atlantic and Southeastern U.S. regions.
Edited for space and clarity.
How is banking venture-backed companies different from banking other businesses?
In the innovation economy, companies tend to be nontraditional. Sometimes they don't have revenue for a year or two. And if they're in the life sciences sector, it could be eight years before they have revenue. Traditional banks would ask to see cash flows, but these companies don't have any yet. We understand that and are accustomed to seeing losses at the beginning.
What are the biggest challenges for tech companies when it comes to getting credit?
Having a path to revenues and a path to profitability, and showing “here's what I see.” It's not that they have to be there within X number of days, it's just showing they have a vision and a path to get there.
How do you control for risk, given the failure rate of tech startups?
We don't feel it's as big a risk as people tend to think. We also manage the risk, versus just avoiding it. When we're looking at these companies, and they have a sponsor like a venture capital or private equity firm, we develop relationships with the sponsors. We lean on their due diligence and they lean on ours. That helps a lot.
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We love awesome apparel brands here at Coolector HQ and, as luck would have it, we run into them all the time with our daily trawling of the internet in search of top notch brands. The latest to have caught our attention goes by the name of Grits Co Clothing and you won’t be surprised to hear, given our proclivity for both, that illustration and typography feature heavily in all of their designs.
Grits Co Clothing is a Southern inspired purveyor of awesome looking menswear that heralds from Houston, Texas. An area which is synonymous with its detailed representation of the Southern experience in an unapologetic way. The slogan of Grits Co Clothing is a straightforward one and one that sums up their ethos pretty well – “No Grits No Glory” – and it serves as a reminder to to persevere with trying to reach your goals in life.
The superb aesthetics and lifestyle of Deep South of the United States permeates all the way through the excellent selection of apparel to be found at Grits Co Clothing and if you like your tees and sweaters stylish and typographic centric then you really need look no further.
Grits Co Clothing words strive to use the narratives of their Houston lifestyle that inspire their way of life and it shines through in their T-shirt designs. The vintage looking wares that they produce and the fabrics used in their construction serve as the ideal canvas to showcase their way of living.
We’re big fans of brands that make their apparel in the right way and strive to offer only quality wares by placing quality over quantity and this is certainly praise that can be levied in the direction of Grits Co Clothing who produce small batch runs of excellent looking T-shirts and sweaters that are snapped up by loyal fans of the brand.
Work Hard, Play Hard
There is a real sense of the American dream at play with the apparel from Grits Co Clothing and we’re mighty impressed with their first class line up of apparel that will be perfect for those looking to ramp up their wardrobe options this winter. Whether its the cornerstone “No Grits, No Glory” apparel or some of their more illustrative wares that catch your eye, you’re sure to find something that matches your personal preferences on their excellent online store.
An awful lot of our favourite apparel brands here at Coolector HQ happen to originate from the USA but this is certainly one of the first from the Deep South to have caught our eye and, given the quality of the wares at Grit Co Clothing, we’re sure it won’t be the last. Definitely one to keep an eye on for 2017.
See More: Grits Co Clothing

domain: design


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A good piece of news for those who didn’t have a chance to get into the world’s most popular school af magic: now you have opportunity to visit the Wizarding World’s main drag, Diagon Alley, from the comfort of your desk asÂ Google added the set of Diagon AlleyÂ to Google Street View.
Now muggles can skip the trip to England and make a virtual visit to the cobblestone streets from the comfort of their own desk, reports The Huffington Post.
Harry Potter fans will notice the features, thoroughly described in the same-namedÂ films.Â It took the filmsâ€™ team six months to create the 20,000 objects and packages that now can be spotted inside the windows of the virtual shops.
By the way, this is not the first timeÂ the Internet searching giant has decided to map out an outlandish location.
It’s also known for its Amazon Rainforest from Street View. Besides, the Google crew has recently added Battleship Island to their mapsâ€”the location that inspired Javier Bardemâ€™s hideout in the James Bond movieÂ Skyfall.
But Diagon Alley is the first fictional location Google has ever mapped.
The news comes a day after reports surfaced of a Chinese Harry Potter who has conjured up a personal fortune after creating an online “spell” emporium, earning aboutÂ Â£109,000 each month.
Luo Shun launched his “business” last year and has since become extremely popular among those who seek paranormal solutions to their distinctly terrestrial problems.
“Writing spells is a sacred thing,” Mr Luo, 31, told reporters. “[You must] calm your heart, shower and change clothes [and] be guided by the Holy Spirit.”
“I witnessed many quite mysterious scenes and I wanted to find the answers,” Mr Luo added, revealing that he had studied feng shui with “experts”.
And now Mr Luo has earned respect from clients who hoped to find love, atone for sins or improve relations with their relatives and friends.
The 31-year-old had initially seemed to become linked to a career in accounting. However, after two years at the Changsha University of Science and Technology he left the course, believing that his future lay in the ancientÂ ChineseÂ art of feng shui.
“The internet spreads information fastest … so I chose Taobao to sell my spells,” explained the man, whose site now offers more than 160 different spells or products.
Last month the online shop sold 2,825 spells, and the extra popular item has become a Â£33 love charm.
The list of the offered spells includes such names as: “The [build] good relationship between daughter-in-law and mother-in-law spell, improves relations between the two” or “The abortion atonement spell: a spell for driving away the evil spirits [caused by abortion] and soothing the baby’s spirit.”
The now-rich Chinese refused to reveal how much money he was now making but vowed to channel his wealth into philanthropy.
“If I really become rich in the future I will build a football field in my hometown where there is no football field yet [and] open it free of charge for the kids to play on. Or [I will] build a primary school where the kids can develop according to their own interests â€“ or perhaps build a Taoist temple.”

domain: news


Rebecca Lutzy is a Ph.D. student in The Woodrow Wilson School’s Science, Technology, and Environmental Policy (STEP) program. Her doctoral research focuses on the impact of Congressional politics, including political polarization, on United States federal climate and clean energy policies. Her research approach draws from political science methods for analyzing legislator preferences and from climate and energy analysis methods for incorporating energy use, production, and greenhouse gas emissions data and goals.
Among other topics, she seeks to distinguish geographic and natural resource determinants of legislator preferences from other stakeholder and interest group impacts on policymaking.
Rebecca spent May through September of 2010 as an energy and environment Policy Fellow for Senator Robert Menendez of New Jersey, focused on legislation considered by the Senate Energy and Natural Resources Committee and the Senate Environment and Public Works Committee. She was born and raised in New Jersey.


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Author: Jane L. Thompson
Release Date: 2013-10-22
Genre: Social Science
Sociology: Made Simple covers issues being discussed in contemporary sociology. The book tackles Sociology with regard to its definition, social sciences, theories, and different approaches (i.e., positivism, functionalism, symbolic interactionism, and Marxist sociology). The text also discusses social class in Britain; family life in contemporary Britain; the main aspects of the sociology of education; and studies in youth culture. The effects of mass media, industrialization, work, poverty, welfare, state, politics, and distribution of power in the process of social control are also considered. Each chapter of the book is provided with lists of further reading. Students engaged in sociology course and general readers will find the book invaluable.
Author: Henry L. Tischler
Publisher: Cengage Learning
Release Date: 2010-01-01
Genre: Social Science
This revised edition of Tischler's INTRODUCTION TO SOCIOLOGY continues a tradition of providing a proven and comprehensive textbook to students and professors at a lower, very reasonable price. With its built in study guide, practice tests, and available access to SociologyNow, no other textbook on the market provides students with a complete suite of study aids at an affordable price as INTRODUCTION TO SOCIOLOGY. Tischler is known for providing full coverage of sociological concepts in a student-friendly manner, and threading two basic ideas throughout the text- 1) sociology is a rigorous, scientific discipline and 2) a basic knowledge of sociology is essential for understanding social interaction in many work and social settings. Each chapter progresses from a specific to a general analysis of society - each part introducing increasingly comprehensive factors necessary for a broad-based understanding of social organization. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.
5,600 Exam Prep questions and answers. Ebooks, Textbooks, Courses, Books Simplified as questions and answers by Rico Publications. Very effective study tools especially when you only have a limited amount of time. They work with your textbook or without a textbook and can help you to review and learn essential terms, people, places, events, and key concepts.
Author: Abraham P. Sperling
Release Date: 2013-10-22
Psychology: Made Simple covers the development of psychology over the years and the basic psychological knowledge. The book describes the scientific approach to the study of the human nature, the physiological aspects of psychology, perception, and the processes of learning. The text also discusses John Dewey’s analysis of reasoning; creativity, logic, critical thinking, and divergent and convergent thinking; the nature of thinking; and the relationship between thinking and language. The process of remembering; intelligence and aptitudes and tests used to measure both; the basis of individual differences; and the psychology of infancy, childhood, and adolescence are also considered. The book tackles the theories of emotions and personality development, the role of motivation in personality development; personality adjustment and maladjustment; and the neurotic and abnormal personalities. Issues in social psychology are considered as well. Students taking psychology, social sciences and education will find the book invaluable.
Author: Peter Morrall
Release Date: 2009-03-04
This lively, introductory text provides students and health practitioners with the foundations of a sociological understanding of health issues. Written for anyone who is interested in health and disease in contemporary global society, this book engages the reader to act upon their occupational and moral responsibilities. It explains the key sociological theories and debates with humour and imagination in a way that will encourage an inquisitive and reflective approach on the part of any student who engages with the text. With individual chapters covering sociology, health, science, power, medicalisation, madness happiness, sex, violence and death, Sociology and Health is organized so that the student moves through sociological approaches and themes which constantly recur in the experience of healthcare. Students will find this a readable and controversial text which covers the ground they need to know in a thought-provoking way. Lecturers will find it a helpful text for generating discussion in tutorials and seminars. There are summaries at the end of each chapter, suggestions for further reading and ideas for the reader.
Author: A. Stroll
Release Date: 2012-09-10
Genre: Business & Economics
Philosophy Made Simple will be of particular interest to students beginning degree courses in philosophy and to those who are studying it as an ancillary subject within courses such as sociology, education, linguistics, theology and psychology. It will, in addition, be useful for a variety of liberal arts courses in adult education. The book also provides a valuable basis for an introductory self-study course. Avrum Stroll is Professor of Philosophy at the University of California, San Diego, USA. Richard H. Popkin is presently Professor Emeritus, Washington University, St Louis and Adjunct Professor, History and Philosophy at UCLA, USA.
Complex Numbers lie at the heart of most technical and scientific subjects. This book can be used to teach complex numbers as a course text,a revision or remedial guide, or as a self-teaching work. The author has designed the book to be a flexible learning tool, suitable for A-Level students as well as other students in higher and further education whose courses include a substantial maths component (e.g. BTEC or GNVQ science and engineering courses). Verity Carr has accumulated nearly thirty years of experience teaching mathematics at all levels and has a rare gift for making mathematics simple and enjoyable. At Brooklands College, she has taken a leading role in the development of a highly successful Mathematics Workshop. This series of Made Simple Maths books widens her audience but continues to provide the kind of straightforward and logical approach she has developed over her years of teaching.
Transport and Distribution: Made Simple introduces the whole field of transport and physical distribution practiced in the 1970s. This book discusses the transport in the framework of production, components of a transport system, characteristics of different ways, and effect of traffic characteristics on terminals. The principles in the design of units of carriage, motive power at sea, and outline of the distribution process are also elaborated. This compilation likewise covers the documents for road haulage operations, development of the common transport policy, and control of rail transport. This text provides a wide range of examination syllabuses at an intermediate and higher level, covering the introductory syllabuses of the Chartered Institute of Transport and the Institute of Traffic Administration. This publication is ideal for H.N.C., H.N.D., and CNAA degree students majoring in transport option, as well as sociology students considering the impact of transport on the environment.
This Book Covers The Syllabi Prescribed By Indian Universities At Undergraduate And Postgraduate Level In Sociology In The Paper Concerned With Sociological Methods And Techniques, Social Survey And Research. After Analysing The Nature Of Sociology And Social Phenomena; Fact, Theory And Concept, The Book Describes, Discusses And Evaluates Sociological Data; Social Research; Historical Method And Techniques Of Sociological Research Including Observation; Experiment; Case Study; Social Survey; Mailed Questionnaire; The Schedule; Rating Scales And Sociometry And Calling Interview. In Social Research Separate Chapters Have Been Devoted To Identification Of Problem Of Research; Review Of Related Literature; Formulation Of Hypothesis; Research Design And Investigation; Sampling And Census Investigation. In The End, There Are Chapters On Content Analysis; Formulation Of Generalisations; Objectivity In Social Research; The Research Report; Inter-Disciplinary Approach; Social Research, Survey And Book-Keeping In India And Statistics In Sociology. While Each Chapter Has Been Written In An Analytical Style, Matter Has Been Drawn From Standard Books. Questions Actually Asked In University Examinations Have Been Given At The End Of Each Chapter For Exercise For Examinations. An Attempt Has Been Made To Use Simple Language Avoiding Technical Jargon As Much As Possible. Tables And Figures Have Been Used To Facilitate Understanding. Thus, The Author Has Left No Stone Unturned To Make This Book An Ideal Textbook For The Students And Reference Work For The Teachers.
Is it true that religion is weakening in modern times, or are we facing religious resurgence? What is fundamentalism? How does it emerge and grow? What role does religion play in ethnic and national conflicts? Is religion a fundamental driving force or do political leaders use religion for their own purposes? Do all religions oppress women? These are some of the questions addressed in this book. An Introduction to the Sociology of Religion provides an overview of sociological theories of contemporary religious life. Some chapters are organized according to topic. Others offer brief presentations of classical and contemporary sociologists from Karl Marx to Zygmunt Bauman and their perspectives on social life, including religion. Throughout the book, illustrations and examples are taken from several religious traditions.
Author: Joan Ferrante
Publisher: Cengage Learning
Release Date: 2015-01-01
Genre: Social Science
Offering instructors complete flexibility, SEEING SOCIOLOGY: AN INTRODUCTION, 3rd Edition combines up-to-the-minute coverage with an easy-to-manage approach featuring brief, self-contained modules in each chapter that instructors can assign based on the needs of their class. The Third Edition includes such contemporary topics as globalization’s connection to technology and gay rights, the anti-aging industry, and The Affordable Care Act, and many others, reflecting the latest developments in the field. Extremely student-friendly and engaging, the text continues to make photos an integral part of the learning process-resulting in a stronger, more memorable learning experience for students. The new “What Do Sociologists See?” feature includes a sociologist's insights on everyday images, showing students how sociological concepts can be applied to daily life. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.
Author: Andrew Papanikitas
Publisher: Elsevier Health Sciences
Release Date: 2013-05-14
Medical ethics, sociology and epidemiology rarely arouse one's passion and can, as minor subjects within a busy curriculum, find themselves ignored by vast swathes of students. However, recent times have seen not only a greater general understanding of these subjects but also a greater appreciation of their role within modern medical practice. In addition, these subjects are increasingly appearing in exams and, more importantly, they will crop up in every field and at every level of future working lives. In writing this book, the authors hope to provide a springboard from which students can develop a reasoned ethical approach to dilemmas as and when they present, both within their practice of medicine and in the exam situation. The sociology and public health sections aim to provide key information on the theories and studies that have helped to shape the practice of these disciplines - topics that are all too often unacknowledged by medical students and doctors alike. In doing so, the authors hope to provide the essential facts on these subjects without leaving readers to wade through irrelevant material. It is hoped that all students might begin to enjoy evidence (as well as experience)-based medicine and appreciate its importance regardless of the medical or surgical careers that they pursue. More than 80 line artworks, tables and boxes present clinical, diagnostic and practical information in an easy-to-follow manner Friendly and accessible approach to the subject makes learning especially easy Written by junior doctors for students - authors who understand exam pressures Contains ‘Hints and Tips’ boxes, and other useful aide-mémoires Succinct coverage of the subject enables ‘sharp focus’ and efficient use of time during exam preparation Contains a fully updated self-assessment section - ideal for honing exam skills and self-testing Self-assessment section fully updated to reflect current exam requirements Contains ‘common exam pitfalls’ as advised by faculty Crash Courses also available electronically! Online self-assessment bank also available - content edited by Dan Horton-Szar!
Author: John J. Macionis
Release Date: 2002
Genre: Social Science
This brief paperback gives readers the concepts and background of sociology, while guiding them through an abundance of interactive features that explore timely issues and opinions, draw cross-cultural comparisons, and provide numerous learning opportunities. A five-part organization covers specific topics under the major headings of: The Foundations of Sociology, The Foundations of Society, Social Inequality, Social Institutions, and Social Change. For individuals interested in an introduction to sociology.

domain: library


Fi Shock FW-00001T 17 Gauge Aluminum Fence Wire 1320 Foot
by Fi Shock
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|Manufacturer Part Number||FW-00001T|
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Hemophilia Federation of America is a national nonprofit organization that assists, educates and advocates for the bleeding disorders community.
“One Man’s Story” By John Jarratt, M. Ed., L.P.C. Download John’s Story It is my hope that the new millennium will bring about a better understanding of hemophilia and bleeding disorders, along with an improved relationship and collaboration with consumers, chapters, foundations, hemophilia treatment centers, clinics, private practitioners, emergency room personnel, national organizations, and industry. […]
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So good to see you again. It looks like you have a list of places or activities you were interested in checking out. Want to have a look?View temporary itinerary
Just south of Battle Mountain, the trail offers a variety of steep climbs and fast, technical descents through historic mining areas, sagebrush covered canyons and rocky ridges. A Copper Basin Mountain Bike Trail brochure is available at the Bureau of Land Management, Battle Mountain Field Office located at 50 Bastian Road. The brochure contains a detailed map with complete descriptions of each of the three trails including length, skill level, elevation gain, technical level and trail type distances.
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domain: travel


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Murrumba Volunteer Awards Back for 2016
Chris Whiting MP has opened nominations for his second annual Murrumba Volunteer Awards.
‘There are so many people who give so much to our community through volunteer work,’
‘Many volunteers in our community work so hard and it is important that we all recognise their efforts,’ Mr Whiting said
Nominations are open now, and will close at 5pm on Thursday 1 December 2016.
‘Last year we recognised volunteers from across our community, who help out in a variety of fields from their local progress association to putting on local carols at Christmas,’
‘Anyone who gives their valuable free time to help better our community can be nominated for one of these awards,’
‘I encourage anyone who knows someone who volunteers to consider nominating them for an award,’ Mr Whiting said.
Nominations can be submitted to the Murrumba Electorate Office at Rothwell Central, 743 Deception Bay Rd, Rothwell – next to the Commonwealth Bank, or via email: firstname.lastname@example.org or phone: 3448-2100.


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arr. Gary E. Parks - BriLee Music Publishing
"A seafarer's life is a hearty life for certain, yes, for sure..." In keeping with the fine tradition of sea chanteys for young men's voices, this rollicking arrangement of an anonymous tune will be a lot of fun for your guys!
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domain: artistic


Manchester City Council has selected regeneration and construction group Galliford Try Partnerships to deliver 75 new affordable council homes in the north of the city.
Galliford Try Partnerships will work with modular construction specialist ilke Homes to build contemporary three and four bedroom houses on a cleared site in Newton Heath.
Three canal-side blocks of apartments, will also be built using modern methods of construction on the Silk Street site which is owned by the City Council.
Cllr Suzanne Richards, the Executive member for Housing and Regeneration, said: “The pioneering Silk Street project will create up to 75 much needed high quality new Council Homes for Manchester residents.
“We have been clear from the outset that we want to demonstrate the benefits that modular and modern methods of construction can bring to both the quality and speed of delivery of these affordable new homes. Selecting Galliford Try Partnerships and ilke Homes as our delivery partner is another important step forward.”
Stephen Teagle, Chief Executive of Galliford Try Partnerships, said: “This builds on our existing joint working with Manchester City Council in increasing the supply of much needed homes in the city. We are looking forward to working with the partners to deliver high quality homes at pace which will be an enduring benefit for the wider community.”
Dave Sheridan, Chief Executive of ilke Homes, said: “We are delighted to have been selected to be part of the partnership delivering much needed homes through this fantastic project.”
The delivery of the Silk Street project is being followed by architect George Clarke for a new Channel 4 series celebrating 100 years of Council Housing
George attended an initial community event on May 28th to learn more about residents’ aspirations for new housing and further consultations will be held once initial designs are developed and before planning is submitted later in the summer.
Start of construction of the first houses is scheduled for autumn 2019 with the first homes expected to be complete and occupied in 2020.
Manchester based Sixtwo Architects have designed the masterplan for the scheme.


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Kerry Applauds End of Discriminatory Travel Ban
WASHINGTON, D.C. - Senator John Kerry (D-Mass.), the Chairman of the Foreign Relations Committee, today applauded the long overdue enactment of his legislation by the Obama Administration to finally end a travel ban that prevented those with HIV from entering the United States.
Since 1987, the Immigration and Nationality Act (INA) contained a provision to bar HIV positive individuals from travelling or immigrating to the US, including HIV positive doctors and experts, as well as refugees seeking asylum. No scientific evidence supported the ban as effective for disease control or to curb costs to the public health care system.
"Today a discriminatory travel and immigration ban has gone the way of the dinosaur and we're glad it's finally extinct. It sure took too long to get here," said Sen. Kerry. "We've now removed one more hurdle in our fight against AIDS, and it's long overdue for people living with HIV who battle against stigma and bigotry day in and day out."
"At long last, our nation's unjust policy of excluding HIV-positive visitors and immigrants has ended," said Joe Solmonese, President of the Human Rights Campaign. "We applaud the leadership of our allies in Congress, especially Senator Kerry, and of President Obama and Secretary Sebelius in bringing this discriminatory chapter of our history to a close."
"People living with HIV will no longer be pointlessly barred from this country," said Rachel B. Tiven, executive director of Immigration Equality. "We are proud to have been part of a tremendous coalition, including Senator Kerry, former Senator Gordon Smith, and Congresswoman Barbara Lee, who have worked tirelessly to repeal this ban. Every day, Immigration Equality hears from individuals and families who have been separated because of the ban, with no benefit to the public health. Now, those families can be reunited, and the United States can put its mouth where its money is: ending the stigma that perpetuates HIV transmission, supporting science, and welcoming those who seek to build a life in this country."
In 2008, the Senate overwhelmingly passed legislation Kerry co-authored with former Senator Gordon Smith (R-Ore.) to lift the statutory travel and immigration ban as part of the President's Emergency Plan For AIDS Relief (PEPFAR) reauthorization.
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domain: sociology


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A turnaround plan at HW Coates has borne fruit with both turnover and profit up at the chemicals logistics specialist. The profit rise, which was boosted in part by the introduction of new accounting standards under FRS102, was revealed in the company’s latest annual results posted in Companies House. Leicester-based HW Coates saw its turnover climb 12% to £36.4m (2014: £32.6m) with pre-tax profit almost doubling to £12.07m (2014: £6.3m). Its parent company HW Coates (Holdings), which includes a contribution […]
Maritime Transport posted its 13th consecutive year of turnover growth, before it incorporated contributions from Roadways Container Logistics (RCL) into its business.
International Swiss-based freight and logistics business Kuehne + Nagel reaped the benefits of its long term growth strategy with record results in the 12 months to 31 December 2011. Globally, K+N saw net profit rise to CHF606m (£421m) on turnover of CHF19.6bn (£13.6bn), increases of 12.2% and 9% respectively after the effect of the strong appreciation of the Swiss franc against K+N’s major trading currencies was stripped out, according to Tim Scharwath, vice-president for global air logistics. In K+N’s four […]


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Universal Flat Aerosol Paint 12 Ounces - Black
RUST-OLEUM-Interior/Exterior Universal Aerosol Paint: Flat. This universal paint is a premium all-surface paint that provides the ultimate long-lasting protection and durability. This breakthrough rust preventive formula adheres to plastic; wood; metal; concrete; wicker; aluminum and masonry surfaces. Featuring a comfort-grip trigger that eliminates finger fatigue caused by continuous spraying. Any angle spray allows you to spray even upside down. Warning: Some children's products are manufactured in a way that may hinder maximum paint adhesion: test in a hidden area. Each container holds 12 ounces. Conforms to ASTM D4236. Contains no CFCs. Made in USA.
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Regular Price:$10.99 per EA

domain: chemistry


ZONA - Spirit of the West plays today's mix of classic rock, cowboy anthems, and acoustic ballads. Playlist refreshed on 11/27/15 by Bumper Morgan. Thanks for listening!
Your favorite songs! Any genre. Any era.
Timeless Broadway, movie, TV and cabaret showtunes & standards featuring top vocalists of today & yesterday.
Children's songs from popular kids shows and movies, including Disney and Nick Jr, specializing in songs for younger children.
Longtime, long-ago WPRO DJ Holland Cooke, netcasting 24/7/365 from Block Island
Cruisin’ Songs & Full Throttle Hits! Music is an essential part of the Car Kulture and Custom Motorcyclers life! After all its the beat that sets the pace! This station is for those who love music with a Hot Rod attitude. Host Oldies DJ Rudy The ”K
Instrumental arrangements of Christmas Favorites.
Joseph maas's Broadcast
The Big Soul Classics from the 60s,70s,& 80s along with a select few from the 50s. All in 96kbps MP3 PRO CD Quality,
Chase Bell plays from his latest albums Skywords and I Know U U Know Me.
AK's personal picks of his favourite electronic music, encompassing everything from ambient to trance and basically anything he likes.


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All year long, Rêves d'automne, Festival of Painting will keep you posted about new events as well as its different activities. Stay up to the minute on the latest news!
The next Rêves d'automne will take place from September 21st
till September 30th, 2012.
© All rights reserved, Rêves d'automne, Festival of painting, 2011
Credits Photos: Marc Archambault, J-F Bergeron / EnviroFoto, Antoine Girard, Charlotte Harvey,
Humberto Pinochet, François Rivard, Ginette Vandal, Journal Le Soleil, Jean-Marie-Villeneuve


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In April 2008, five U of O students traveled to NASA's Johnson Space Center in Houston to conduct a self-designed experiment in reduced gravity. They called the trip the thrill of a lifetime.
Tyler Wilson said roller coasters and amusement parks will never be the same for him again. Kathy Erickson called it an experience of a lifetime. Jessica Reed described it as the most amazing thing she has ever done.
The three U of O students were discussing their experience in NASA’s Reduced Gravity Student Flight Program at the Johnson Space Center. Chemistry Professor Dr. Brian McFarland and students Wilson, Erickson, Reed, Brett Spahn and Jessie Gibson were part of a U of O "microgravity team" that spent 10 days in late April at NASA headquarters in Houston.
The U of O team spent the time in Houston preparing and conducting a self-designed and self-constructed experiment in a reduced gravity environment. The students underwent a series of evaluations, training and equipment modifications that culminated in flights aboard a specifically modified C-9 cargo transport jet that can produce periods of weightlessness lasting 18 to 25 seconds at a time. The plane, dubbed NASA’s "Weightless Wonder," flew about 30 parabolas --- a steep climb followed by a free fall --- over the Gulf of Mexico.
U of O students (front row, from left) Jessica Reed, Kathy Erickson, (second row) Tyler Wilson, Jessie Gibson and Brett Spahn had to go through physiological training before experiencing microgravity.
In order to apply for the program, the Ozarks team had to come up with a viable experiment, develop it, and make a proposal to NASA. Ozarks’ experiment was to determine if microgravity has an effect on water absorption by polyelectrolytes. The highly absorbent polyelectrolytes are valued for their ability to retain water, a quality that makes it useful in diapers and potting soil. The precise influence of gravity on the polyelectrolyte effect had never been tested before.
McFarland and Reed came up with the experiment idea last summer while Reed was working in a summer internship program in a chemistry lab at the University of Southern Mississippi. All five students helped compile the 21-page proposal to NASA.
"We really put a lot of work into it, and we had no idea what to expect," said Reed, a junior biology and chemistry major from Emory, Texas. "It was probably better we didn’t know what we were getting ourselves into. I had no idea how competitive a program it was until after we got selected."
The Ozarks team’s reduced gravity experiments went off without a hitch. Though only four students per team are typically allowed to fly, Ozarks’ team alternate, Gibson, was allowed to fly with another team that was short a member.
The students said their experience in reduced gravity was a thrill of a lifetime.
"It was truly one of the ‘wow’ moments of my life," said Reed. "There’s really nothing that compares with weightlessness. I can’t even find the words to explain it."
Wilson, a junior pre-med major from Claremore, Okla., said, "after experiencing that, a roller coaster will seem pretty tame."
Though the U of O team was still analyzing the results of the experiment several weeks after the test flights, early indications were that microgravity did affect the polyelectrolytes’ absorption speed and ability. The team will issue a final report to NASA three months after the flight, analyzing the experiment’s effectiveness, scientific findings and the conclusions that were drawn from the results.
Jessica Reed and Tyler Wilson get their first taste of reduced gravity aboard the "Weightless Wonder."
"This kind of testing can have a lot of implications for future space travel," McFarland said. "NASA doesn’t accept these proposals unless they can be beneficial. I think it was a very rewarding experience for our students to come up with an experiment and follow it all the way through the process."
Erickson, a senior psychology major from Waldron, Ark., said the lengthy processes of developing and refining the experiment and submitting stacks of paperwork was well worth the effort.
"There was a lot of stress involved in meeting deadlines and getting things finished, but it was so very much worth it," she said.
Before they could fly, the students had to undergo physiological training, including adjusting to hypoxic conditions, or deficiency of oxygen.
"When hypoxic, people often experience a sensation of lightheadedness and giddiness, which from what I hear produced some pretty funny moments during training," McFarland said.
McFarland first learned of the program while in graduate school at the University of Southern Mississippi. Though he wasn’t eligible to apply for the program because he was a graduate student, McFarland knew many of the USM students who took part in the program. He invited one of the former USM students to Ozarks last fall to talk about the NASA program and spark interest.
Part of the proposal the U of O team submitted to NASA included an education outreach component that will have the Ozarks students talking about the NASA program to other college students and students in high school and junior high.
"Hearing from someone who had been through the program was what really got me interested in going for it," said Reed. "Now that I’ve been through it, I can’t wait to talk about the program and the opportunities that are out there."
Ozarks was one of 40 teams of college students from throughout the country that participated in the annual program that was started by NASA in the mid 1990s. Only about 40 percent of all colleges that apply are chosen for the program. Ozarks is only the third university from Arkansas to participate in the program.
"The students are already talking about applying next year with a follow-up experiment," said McFarland. "Even before we got back home they were talking about their next experiment proposal."
(This story by Larry Isch, Director of Public Relations, first appeared in the Spring/Summer 2008 issue of Today magazine.)


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Personal Letters From Robert N. Sorensen to the Sorensen Family, dated 1951-1954. The letters mostly detail his career with the Air Force, including his stateside training and service as well as his combat missions in Japan.
Sorensen, Robert N.--Correspondence; Sorensen, Alma Nicholas 1879-1958--Correspondence; Sorensen, Mary Carlisle, 1894-1962--Correspondence;
The Butterflies of North America (Second series), with List of Species of the Diurnal Lepidoptera of America North of Mexico by William H. Edwards. Boston : Houghton, Mifflin, 1884. The original contains green half calf binding over dark maroon...
Program of the last meeting of the Last Squad Club in Helper, Utah, March 1, 1986. Please see item titled "Photograph of the Last Squadron Club final meeting, March 1, 1986" in this collection for a photograph of the event.
Lee, J. Bracken (Joseph Bracken), 1899-1996; Clubs; Meetings; World War, 1914-1918--Veterans;
Photograph of the final meeting of the Last Squad Club, March 1, 1986. J. Bracken Lee is on the right. The Last Squad Club was organized by World War I veterans, February 24, 1941 in Helper, Utah. The final meeting was held with the eight...
Lee, J. Bracken (Joseph Bracken), 1899-1996; Clubs; Meetings; World War, 1914-1918--Veterans; Photographs;


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Atlanta Hawks star point guard Trae Young raised eyebrows after his surprising absence from Friday's game against the Denver Nuggets, but he was in no mood to discuss the situation on Monday.
After Shams Charania and Sam Amick of The Athletic reported that an exchange between Young and head coach Nate McMillan led to him being away from the team during a 117-109 victory, the two-time All-Star is not happy how that information got out. While speaking to reporters on Monday, he declined to explain his side of the story and instead lamented on his annoyance at the matter being made public.
"We're all grown men here, and sometimes we don't always agree," Young said. "It's unfortunate that private situations and private conversations get out to the public, but I guess that's the world we live in now. But I'm just focused on basketball and focused on helping my team win, and that's what I've got to get to refocusing on."
When questioned further about his absence from the game, Young sternly said, "A private matter needs to stay private."
Bleacher Report @BleacherReport
"You don't know the full story. ...A private matter needs to stay private"

Trae Young got into it with this reporter 😳

(via @ZachkleinWSB)pic.twitter.com/jVA6jlhjPd
Charania and Amick reported Sunday that McMillan presented Young with an ultimatum to either come off the bench or not show up to the arena at all after he wanted to miss the pregame shootaround to focus on treatment for his injured right shoulder.
Young, who was planning to make a decision later in the day after treatment, chose not to play and was listed as out with shoulder soreness.
The 24-year-old didn't face any disciplinary action from the team and returned to practice on Sunday. McMillan described the situation as "just a miscommunication." However, the report from Charania and Amick indicated a deeper issue within the franchise, stating there were "multiple team meetings early this season to resolve various conflicts."
Atlanta sits in fourth place in the Eastern Conference at 13-10, but it has struggled to maintain consistency through the early part of the season.
With Young returning to the lineup on Monday, the Hawks will be going for their third straight win when they host the Oklahoma City Thunder (10-13).


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I know that there is something like a 'structured eating' as I have done this program some times ago. And yes, it truly worked for me that time. I am also so much grateful for making these programs publicly accessible. They are a blessing.
These days I have lost some weight with another, completely new approach. And it is not very much like 'structured'.
I don't know how long this approach will last, but for the moment it still works for me.
This new approach is, that I only eat when I am really hungry. And then only healthy stuff.
And I don't eat what I don't like, but only eat what I right now 'feel for'.
I guess, the difference is that I am thinking now thinking: life is short, and I am old enough to determine, what I want to eat. And only pick that one specifically, not more, if I don't really want any other things. Maybe you could call it an extremely choosy approach.
However, one important thing I learned from this program too, and that I also keep today: I don't wait until the point when I am so hungry that I would overeat. That is truly critical.
Another thing I have changed for success: I really enjoyed cooking healthy recipes for my family and myself. But I recently recognised how the daily cooking makes me also eating then when I am not specifically hungry. I usually argued (bargained), "this is so healthy, so I HAVE to eat it". Well, no. Just because it is healthy, I don't need to make my body working all the time and give them work to process all the healthy ingredients. Or at least, not now, and not for a while.
I am still eating healthy, but I only follow my truly own inner desire for food.
Not sure if this is any helpful that I am writing. I just wanted to reply to you - actually much earlier. I found the energy only today to write this down.
No matter what you choose to eat studies are quite clear that to lose weight one has to cut calories from their diet or burn calories with exercise; ideally both! How do you manage your calories? How do you burn calories? Any tips or thoughts on calories in and calories out?
Hope to read some of your ideas!

domain: health


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- Open Access
Association of IFITM3 rs12252 polymorphisms, BMI, diabetes, and hypercholesterolemia with mild flu in an Iranian population
Virology Journal volume 14, Article number: 218 (2017)
IFITM3 has been suggested to be associated with infection in some ethnic groups. Diabetes and hypercholesterolemia are also important clinical conditions that can predispose individuals to infection. The aim of this study was to investigate the association of rs12252 C polymorphism, BMI, diabetes, and hypercholesterolemia with mild flu in an Iranian population.
We conducted a case-control study, including 79 mild flu and 125 flu-negative individuals attending primary care centers of three provinces of Iran (i.e, Markazi, Semnan, and Zanjan). Pharyngeal swab specimens were collected from all participants, and were subjected to RNA and DNA extractions for Real-time PCR and PCR tests. All PCR products were then sequenced to find T/C polymorphisms in the rs12252 region. Data on demographic, anthropometric, and clinical variables were collected from participants’ medical records available in the primary care centers. The data was analyzed using DNASIS (v. 2.5) and Stata (v.11) software.
All participants were of Fars ethnic background. The allele frequency for rs12252-C was found to be 9.49% among cases and 2.40% among controls. Carriers of the rs12252 C allele (CT + CC genotypes) showed 5.92 folds increase in the risk of mild flu comparing to the T allele homozygotes (P value: 0.007). We also found a significant positive association between rs12252 C allele heterozygote and mild flu (OR: 7.62, P value: 0.008), but not in C allele homozygote group (OR: 2.71, P value: 0.406). Similarly, we did not find a significant association between mild flu and BMI (OR: 1.06, P value: 0.087), diabetes (OR: 0.61, P value: 0.392), and hypercholesterolemia (OR: 0.50, P value: 0.393) in multivariable logistic regression.
This is the first study evaluating the association between rs12252 polymorphisms, diabetes, hypercholesterolemia, and BMI and susceptibility to mild flu in an Iranian population. Our results suggest a significant positive association between mild flu and rs12252 C allele heterozygous and carriage. Future replication of the strong association observed here between rs12252 C allele carriage and mild flu might candidate this polymorphism as a genetic marker for early screening of susceptibility to mild flu. Lack of significant association between C allele homozygous and mild flu, observed in this study, might be the result of small sample size in this group.
Influenza is the result of both host and viral genetic components combination. The viral genetic determinants and host immunity have been widely considered, while the host genetic determinants remain elusive . The study of the host genetic factors involved in susceptibility to influenza is a promising strategy that may identify potential therapeutic targets . As a result, systematic investigation of the association between host genetic factors and the occurrence of influenza is of pivotal importance. In 2009, the World Health Organization (WHO) identified as priority the studies which considered the role of host genetic factors on susceptibility to severe flu .
During viral infection, viral proteins and viral nucleic acids are detected by pathogen recognition receptors (PRRs). These recognition patterns activate signaling transduction pathways that trigger production of type I interferon and other related cytokines [3, 25]. Type I interferon then elevates the expression of hundreds of genes, named interferon stimulated genes (ISGs), that weaken virus replication by a variety of mechanisms [3, 25].
It has been suggested that the expression of interferon-inducible transmembrane (IFITM) genes restrict the replication of several highly pathogenic human viruses, especially those that enter the cell via acidic endosome [3, 10, 26]. These viruses include severe acute respiratory syndrome (SARS), coronavirus, Marburg and Ebola viruses, influenza A viruses (IAVs), dengue virus, and HIV-1 [2, 3, 5, 14, 20].
In humans, it has been predicted that rare SNP rs12252-C allele of IFITM3 produces an alternatively spliced transcript that encodes a truncated protein (Δ21 IFITM3) leading to reduced control of virus replication in vitro. However, expression at mRNA or protein level of the Δ21 IFITM3 variant has not been detected to date [7, 9].
The value of IFITM3 in influenza virus infection was determined by Everitt et al. who showed that severity of influenza virus infection was greatly increased in IFITM3 knockout mice compared to the wild-type animals . Everitt et al. and Zhang et al. demonstrated increased morbidity and mortality in rs12252-C homozygotes during the H1N1 influenza pandemic. Due to the high frequency of the rs12252-C allele in Asians, the effect of the homozygosity for this allele was proposed to translate to a population-attributable risk of 54.3% for severe flu in the Chinese population compared with 5.4% in Northern Europeans. Both studies were performed with small sample sizes of H1N1-infected patients, calling for further studies on large sample sizes. Two studies reported a strong association between IFITM3 SNP rs12252-C and worse clinical outcomes in patients infected with 2009 IAV pandemic. The studies, however, doubt the presence of such association, at least among Europeans, as several rs-12,252-C homozygous patients only developed a mild flu [9, 31].
It appears that IFITM3 inhibits an early event after endocytosis of virion particles, by blocking virus release into the cytosol [1, 10, 28]. IFITM3 protein is considered to be the most active against IAV and resides in the late endosomes and lysosomes using several orthologous genetic approaches [3, 14]. Wang and colleagues showed that inflammatory immune responses linked to the C/C IFITM3 genotype during H7N9 infection play an important role in the pathogenesis of influenza. They found that patients with rs12252-C/C IFN-IFITM3 genotype had more rapid disease progression, and were less likely to survive .
Although previous studies concluded that the rs12252-C variant leads to reduced control of virus replication in vitro, posterior studies did not find such effects. For example, Mills et al. found an association between rs12252 rare allele C/C homozygotes and susceptibility to mild flu but they could not confirm previous reports for the association between this polymorphism and susceptibility to severe H1N1 infection . The data obtained by López-Rodríguez et al. did not either suggest any role of rs12252-C in the development of severe IAV in their studied population. They suggested these groups might be at risk of severe influenza, hence individualized measures in the case of IAV is required .
Giao et al. also showed that except H1N1 influenza (pdm09), the risk of hospitalization due to other respiratory infections was higher among rs12252 C allele carriers comparing to patients with TT genotype .
It has been reported that local accumulation of cholesterol to the plasma membrane is important for clustering of viral structural proteins in lipid rafts to help assemble the virus particles . Thus, the imbalance in cholesterol level may play a role in the susceptibility to influenza. The IFITM3 gene mutation may lead to an increase in impaired cholesterol levels . As an instance, mutation rate of IFITM3 gene is shown to be high among Han Chinese population. Coronary artery disease and ischemic stroke are highly associated with BMI and serum cholesterol levels, and are the leading causes of morbidity and mortality in Han Chinese population [8, 12, 23]. Therefore, we performed this study to identify the association between mild flu and IFITM3 rs12252-C polymorphism, BMI, diabetes and hypercholesterolemia.
Written informed consent was obtained from all participants. All procedures performed in this study involving human participants were according to the principles Helsinki declaration. The research protocol was approved by the Ethics Committee of Pasteur Institute of Iran (Ethics code: IR.PII.REC.1395.3).
We performed a case–control study on the samples collected from March 2015 to December 2015 in three provinces of northern-central Iran, including Markazi, Semnan, and Zanjan. Cases would be included in this study if they had apparent symptoms of respiratory tract infection, and were confirmed as mild flu with PCR test. Controls were flu-negative individuals based on the PCR results, and would be included in the study if they had no history of influenza. Both cases and controls should be based and currently residing in Markazi, Semnan, or Zanjan provinces. Having respiratory comorbidities, consumption of immune suppressive drugs, and previous vaccination against influenza virus were our exclusion criteria.
Demographic and anthropometric characteristics measured for each participant included participants’ age (in years), province (Markazi, Semnan, and Zanjan provinces), Body Mass Index (BMI, kg/m2), diabetes (Yes/No), hypercholesterolemia (Yes/No), and genotype in the IFITM3 rs12252 locus. The BMI of each participant was calculated using the formula: BMI = [weight (kg)] / [height (m)]2. The diabetes and hypercholesterolemia positive and negative cases were confirmed based on the patients’ history reports. To test for influenza, pharyngeal specimen from each individual was obtained with a Dacron swab. Specimens were collected on dry ice in transport media containing Pen/Strep and Amphotericin B, and then were transferred to Pasteur Institute of Iran for determination of IAV. All samples were stored at 4 °C for 24 h. Following vortex, swabs were discarded and the supernatants were aliquoted in sterile labeled micro-tubes and stored at −80 °C for further testing.
Detecting IAV in swab samples
Viral RNA extraction
For each sample, viral RNA was extracted from 200 μl fluid specimen using High Pure Viral RNA Kit, according to the manufacturer’s instructions (Roche, Switzerland). The extracted RNA was isolated and re-suspended in 50 μl Elution Buffer and stored at −80 °C for Real-time PCR assay.
Primers and probes design
In quantitative real-time PCR (qRT-PCR), primers and probes were designed and synthesized by SinaClon Co. (Iran) based on the latest WHO guideline. Table 1 describes the primers used for amplification of viral genes and RNaseP as housekeeping control.
One-step quantitative real-time PCR
Real-time PCR reactions were performed in total volume of 20 μl, using Rotor-Gene Q (QIAGEN). The reaction mixture consisted of 2X Master Mix, SuperScriptIII RT/Platinum Taq Mix, specific primers and fluorescent probes. The thermal cycling program was followed based on WHO guideline. Briefly, reverse transcription was carried out at 50 °C for 30 min, followed by 95° for 2 min Taq inhibitor activation, and amplification at 95 °C for 15 s followed by 55 °C for 30 s.
Genotyping of human IFITM3 rs12252
Human DNA extraction
For each sample, genomic DNA was extracted from 100 μl fluid specimen using DNP™ High yield DNA Purification Kit, according to the manufacturer’s instructions (Cinnagen, Iran). Briefly, 400 μl of Lysis Solution was added to each sample. Following vortex and addition of precipitation solution, a second round vortex was performed. The samples were then centrifuged. Wash buffer was used for two times to wash the precipitation. Finally, solvent buffer was added and the tubes were warmed at 65 °C for 5 min. The supernatant, which was the purified DNA, was stored at −20 °C for PCR assay.
Primers for PCR were designed and synthesized by SinaClon Co. (Iran) based on previous published articles . The primers used for the amplification of human IFITM3 rs12252 were as follow: IFITM3-F 5′-GGAAACTGTTGAGAAACCGAA-3′ and IFITM3-R 5′-CATACGCACCTTCACGGAGT-3′ to produce 351 bp PCR product. The18 S rRNA was amplified as internal housekeeping using theses primers sequences: 18 S-F 5′-GGCCCTGTAATTGGAATGAGTC-3′ and 18 S-R5′- CCAAGATCCAACTACGAGCTT-3′ to produce 145 bp PCR product.
PCR reaction was performed in total volume of 25 μl, using Thermocycler (Germany). The reaction mixture consisted of Taq DNA Polymerase 2× Master Mix RED with 1.5 mM MgCl2 (Amplicon, Denmark), specific primers and DNase-free water. Amplification was carried out at 95 °C for 30 s in order to pre-denature the template DNA, followed by 40 cycles of denaturation at 95 °C for 30 s, annealing at 60 °C for 1 min and extension at 72 °C for 1 min. The final extension was completed at 72 °C for 5 min. The PCR products were purified using PCR purification kit (Millipore), and subjected to sequencing (First Base Co, Malaysia) using the BigDye® Terminator v3.1 cycle sequencing kit chemistry. Then they were loaded into DNA Analyzer (GATC Biotech). Both sense and antisense strands of PCR products were directly sequenced using the same primers as the PCR amplification. SNPs were detected by direct sequence analysis using DNAsis MAX.3 software. The reference sequence for the IFITM3 gene was based on the sequence of human chromosome 11, clone GRCh38.p2.
Genetic and statistical analysis
Hardy-Weinberg equilibrium (HWE) was tested in cases and controls using the web tool developed by Rodriguez, and colleagues . Using this tool, allele frequency and genotype distribution were calculated for cases and controls, as well. Statistical analyses were performed using Stata software (version 11). Continuous and categorical data were described in the usual fashion; means ± SDs were used to describe continuous variables, and numbers (percentages) were used to describe categorical variables. Association between categorical variables, including study group (mild flu vs. flu-negatives), rs12252 genotype (CC, CT, TT, and C carriers), rs12252 allele (C and T), province (Markazi, Semnan, and Zanjan), diabetes (positive vs. negative), and hypercholesterolemia (positive vs. negative), was assessed using Pearson’s chi-squared test. For each cell with zero counts in contingency tables, Yates’s correction was used. Also, where more than 20% of cells had counts less than 5, the alternative Fisher’s exact test was used instead of Pearson’s chi-squared test. Univariable logistic regression was used to test the association of each independent variable with mild flu. Variables with a P value smaller than 0.2 in the univariable model were included into the multivariable logistic regression. Also, a backward method using likelihood ratio tests (LRT) was used to make the model as simple as possible. As we sampled cases and controls from three distinct provinces of Iran, we retained the variable “province” in the final model. This was to ensure that residual population admixture, due to differences in participants’ area of residence, does not confound the association between rs12252 genotypes and mild flu. All statistical tests were two-tailed with a type I error of 0.05. Observed powers of the estimated crude and adjusted odds ratios (OR) were also calculated to assess the robustness of our results (Additional file 1).
A total of 79 mild flu cases and 125 controls were included in this study. Participants’ mean age in the case and control groups was 46.46 (SD: 22.90) and 50.62 (SD: 25.30) years, respectively (P value t-test: 0.275). All participants were of Fars ethnicity, which is the dominant ethnicity in Iran. The distribution pattern of flu-positive and flu-negative individuals was similar across three provinces, with Semnan having the highest number of both cases (45.57%) and controls (72.80%), and Zanjan having the lowest number of cases (12.66%) and controls (7.20%). The difference in the number of cases and controls was significant between Semnan and Zanjan (ORSeman vs. Zanjan: 0.36, P value: 0.039), but not between Semanan and Markazi or between Zanjan and Markazi provinces. Details of participants’ characteristics are shown in Table 2.
Anthropometric and clinical characteristics of study participants
The mean BMI value was slightly higher among mild flu patients rather than in controls (P value: 0.034). Prevalence of hypercholesterolemia and diabetes was also significantly higher in controls rather than in mild flu patients (P values: 0.042 and 0.005, respectively; Table 2).
Genotyping and genetic analysis
The TT genotype was the most prevalent genotype both among cases (84.81%) and controls (96.00%). Similarly, the CC genotype was the least prevalent genotype in both groups (cases: 3.80%, controls: 0.80%, Table 2). In both groups, the alleles were in HWE (P value > 0.05, Table 3). The distribution of TT, TC, CC genotypes as well as C carriers was not significantly different across three provinces, either in total, or separately among cases and controls (Table 3).
Association of rs12252 polymorphisms, BMI, diabetes, and hypercholesterolemia with mild flu
Results of the univariable logistic regression showed that having TC genotype rather than TT, significantly increased the risk of mild flu (OR: 4.03, P value: 0.025). The same effect, but with greater magnitude, was also observed for the CC genotype rather than the TT genotype, however, this effect was not statistically significant (OR: 5.37, P value: 0.149; Table 2). In the final model, the effect of both TC and CC genotypes on the risk of mild flu showed an increase, but again this effect was only significant in the TC group. Furthermore, carriers of the rs12252 C allele (CT + CC genotypes) showed 5.92 folds increase in the risk of mild flu comparing to the T allele homozygotes (P value: 0.007). In the final model, the effect of BMI, diabetes, and hypercholesterolemia were no longer statistically significant (Table 4). Details of multivariable regression process are presented in Additional file 2.
Advances in the genomic area have enlightened the role of genetic factors in susceptibility to various infectious diseases. In this regard, IFITM3 protein encoded by IFITM gene, have shown to be associated with susceptibility to several viral infections, such as West Nile virus, dengue virus, rhinovirus, corona virus, HIV, respiratory syncytial virus, and influenza A virus [3, 15, 20, 28]. In case of influenza infection, however, it is not clear whether the reported association relates to the infection severity.
In this study, we investigated the association between mild flu and IFITM3 rs12252 variant, BMI, diabetes, and hypercholesterolemia in an Iranian population. Our results suggest a significant positive association between mild flu and rs12252 C allele heterozygous (CT) and carriage (CT + CC), but not between mild flu and C allele homozygous (CC), BMI, diabetes, and hypercholesterolemia.
IFITM/ IFITM3 proteins are membrane-associated proteins, and directly interfere with the virus entry into the host’s cells . Since virus entry often proceeds through endocytosis, it is possible that IFITM proteins are involved in endocytosis, by detecting and eliminating viral invaders before establishment of infection [3, 21]. Therefore, mutation in the gene coding for these proteins can lead to susceptibility to various infections. Yount, et al. (2010) introduced IFITM3 in mouse dendritic cells. They mentioned S-palmitoylation of IFITM3 on proximal cysteines controls its clustering in membrane compartments and its antiviral activity against influenza virus. . Bailey and colleagues also found that IAV lung titers were higher in Ifitm3 knockout mice versus wild-type animals .
The association of IFITM gene polymorphisms with mild and sever influenza has been investigated in different ethnicities. For example, Zhang, et al. pointed to the significant role of IFITM3 genetic variants on the epidemiology of influenza among Chinese individuals . Yang, et al. found a significant association between IFITM3-SNP rs12252 and susceptibility to severe, but not mild flu, among Asian and Caucasian ethnicities . Conversely, Mills, et al. found evidence of an association between rs12252 C allele homozygotes and susceptibility to mild flu in patients with Caucasian ancestry, attending primary care, but could not confirm the association between this SNP and susceptibility to severe flu . Studies conducted by López-Rodríguez and Giao, et al. did not find evidence for the association between rs12252 C allele homozygotes and susceptibility to sever flu [11, 19, 22].
Based on the conclusion from the review paper of Ciancanelli et al. which mentioned IFITM3 SNP could not be a major causal factor, but perhaps a modifier, of the outcome of influenza infection , we also concluded there is only convincing experimental evidence for the role of wild-type IFITM3 but further work is required to define the role of IFITM3 SNPs as modifiers for severe influenza. The inconsistent results reported by studies investigated the association between IFITM3 SNP rs12252 and influenza, made Yang, et al. to conduct a systematic review. Their meta-analysis included 445 patients with influenza and 4180 controls from four studies, including different ethnic and severity subgroups. Their results showed that patients with the rs12252-C/C genotype were more likely to increase the susceptibility to severe but not in mild flu, in both UK Caucasians and Han Chinese .
Our results also showed that rs12252-C carriers have an increased risk of mild flu rather than patients with TT genotype. This may be explained as due to the differences in participants’ ethnic background, since we studied Iranian ethnicities while Yang, et al. focused on UK Caucasians and Han Chinese ethnicities. Although, the rs12252-C allele in the Iranian population was rare, the overall effect of this allele on the risk of influenza was found to be considerably high. As our sample size was small, the power for some of our estimates was not desirable. In case such findings being replicated by future studies, the knowledge can be used in effective management of the epidemics. For example, understanding the biological pathways leading to mild and severe flu may lead to improvement of therapeutic options, and can alter existing vaccination practices. Findings of large-scale studies on genetic susceptibility to influenza would also guide population-based prevention efforts. For example, by considering the genetic susceptibility of different sub-populations to influenza virus in a country, human and medical resources would be allocated to high risk areas in case epidemics/pandemics occur.
The IFITM3 allele frequency varies significantly among different ethnicities. For example, the frequency of rs12252 C allele homozygotes in Han Chinese, Japanese, Northern Europeans, and Englanders has been shown to vary greatly, from 0% among Japanese to 44% among Chinese populations (25, 44, 0 and 2%, respectively) . Little is known about the frequency of this genotype in Iran. In our study, the C allele frequency observed among flu-negative individuals was 2.40%, resembling the allele frequency among Englanders. Studies with larger sample sizes would provide a better understanding about the frequency of susceptibility alleles in Iran.
In this study, we recruited our samples from three provinces of Northern-Central Iran, including Markazi, Semnan, and Zanjan provinces. Although all participants were of Iranian ethnicity, participants of each province might be different regarding their genetic and social history, leading to residual confounding due to population stratification. Population stratification is related to situations when cases and controls are of different ethnic backgrounds with different genetic compositions, and has been noted as the most important type of the bias in genetic association studies. To control for the effect of residual population admixture on our results, we adjusted genetic association between IFITM3-SNP rs12252 and susceptibility to mild flu for participants’ residence area. Growing empirical and theoretical evidence suggests that statistical adjustment for confounding effect of ethnicity provides estimates of genetic associations which are robust to bias from population stratification .
In our study, we did not observe a significant association between rs12252 C allele homozygote, BMI, diabetes, and hypercholesterolemia and mild flu. This might be due to relatively small sample size in our study, which led to moderate power of some parameter estimates. To verify these findings, further studies on the Iranian ethnicity with larger sample sizes are recommended.
To the best of our knowledge, this is the first study evaluating the association between IFITM3 rs12252 polymorphism, diabetes, hypercholesterolemia and BMI with susceptibility to mild flu in an Iranian sample. Our results suggest a significant positive association between mild flu and rs12252 C allele heterozygous and carriage. However, we did not observe an association between mild flu and rs12252 C allele homozygous, BMI, diabetes, and hypercholesterolemia. Further studies are recommended to verify these findings in a larger sample of Iranian individuals. Future replication of the strong association observed here between rs12252 C allele carriage and mild flu would be beneficial in candidating this polymorphism as a genetic marker for early screening of susceptibility to mild flu.
Influenza A virus
Interferon stimulated genes
Pathogen recognition receptors
Quantitative real-time PCR
Severe acute respiratory syndrome
World Health Organization
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Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan B, Weyer JL, van der Weyden L, Fikrig E, et al. IFITM proteins mediate the innate immune response to influenza a H1N1 virus, West Nile virus and dengue virus. Cell. 2009;139:1243–54.
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Chutiwitoonchai N, Hiyoshi M, Hiyoshi-Yoshidomi Y, Hashimoto M, Tokunaga K, Suzu S. Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins. Microbes Infect. 2013;15:280–90.
Ciancanelli MJ, Abel L, Zhang SY, Casanova JL. Host genetics of severe influenza: from mouse Mx1 to human IRF7. Curr Opin Immunol. 2016;38:109–20.
Compton AA, Roy N, Porrot F, Billet A, Casartelli N, Yount JS, Liang C, Schwartz O. Natural mutations in IFITM3 modulate post-translational regulation and toggle antiviral specificity. EMBO Rep. 2016;17:1657–71.
Cui Q, Ju X, Yang T, Zhang M, Tang W, Chen Q, Hu Y, Haas JV, Troutt JS, Pickard RT, et al. Serum PCSK9 is associated with multiple metabolic factors in a large Han Chinese population. Atherosclerosis. 2010;213:632–6.
Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, et al. IFITM3 restricts the morbidity and mortality associated with influenza. Nature. 2012;484:519–23.
Feeley EM, Sims JS, John SP, Chin CR, Pertel T. Chen L-i, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, et al. IFITM3 inhibits influenza a virus infection by preventing cytosolic entry. PLoS Pathog. 2011;7:e1002337.
Gaio V, Nunes B, Pechirra P, Conde P, Guiomar R, Dias CM, Barreto M. Hospitalization risk due to respiratory illness associated with genetic variation at IFITM3 in patients with influenza a(H1N1)pdm09 infection: a case-control study. PLoS One. 2016;11:e0158181.
He J, Gu D, Wu X, Reynolds K, Duan X, Yao C, Wang J, Chen CS, Chen J, Wildman RP, et al. Major causes of death among men and women in China. New Engl J Med. 2005;353:1124–34.
Horby P, Nguyen NY, Dunstan SJ, Baillie JK. The role of host genetics in susceptibility to influenza: a systematic review. PLoS One. 2012;7:e33180.
Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, et al. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza a virus. PLoS Pathog. 2011;7:e1001258.
Jiang D, Weidner JM, Qing M, Pan XB, Guo H, Xu C, Zhang X, Birk A, Chang J, Shi PY, et al. Identification of five interferon-induced cellular proteins that inhibit West Nile virus and dengue virus infections. J Virol. 2010;84:8332–41.
Kiselev OI, Komissarov AB, Konshina OS, Dmitrieva MN, Deyeva EG, Sologub TV, Pokrovskiy VI. Mutations in human genes that increase the risk for severe influenza infection microb independent. Res J. 2015;2:10–8.
Konig R, Stertz S, Zhou Y, Inoue A, Hoffmann HH, Bhattacharyya S, Alamares JG, Tscherne DM, Ortigoza MB, Liang Y, et al. Human host factors required for influenza virus replication. Nature. 2010;463:813–7.
Lander ES. Initial impact of the sequencing of the human genome. Nature. 2011;470:187–97.
López-Rodríguez M, Herrera-Ramos E, Solé-Violán J, Ruíz-Hernández JJ, Borderías L, Horcajada JP, Lerma-Chippirraz E, Rajas O, Briones M, Pérez-González MC, et al. IFITM3 and severe influenza virus infection. No evidence of genetic association. Eur J Clin Microbiol Infect Dis. 2016;35:1811–7.
Lu J, Pan Q, Rong L, He W, Liu SL, Liang C. The IFITM proteins inhibit HIV-1 infection. J Virol. 2011;85:2126–37.
Mercer J, Schelhaas M, Helenius A. Virus entry by endocytosis. Annu Rev Biochem. 2010;79:803–33.
Mills T, Rautanen A, Elliott KS, Parks T, Naranbhai V, Ieven MM, Butler CC, Little P, Verheij T, Garrard CS, et al. IFITM3 and susceptibility to respiratory viral infections in the community. J Infect Dis. 2014;209:1028–31.
Niu N, Zhu X, Liu Y, Du T, Wang X, Chen D, Sun B, Gu HF, Liu Y. Single nucleotide polymorphisms in the proximal promoter region of apolipoprotein M gene (apoM) confer the susceptibility to development of type 2 diabetes in Han Chinese. Diabetes Metab Res Rev. 2007;23:21–5.
Rodriguez S, Gaunt TR, Day INM. Hardy-weinberg equilibrium testing of biological ascertainment for mendelian randomization studies. Am J Epidemiol. 2009;169:505–14.
Sadler AJ, Williams BRG. Interferon-inducible antiviral effectors. Nature Rev Immunol. 2008;8:559–68.
Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P, Rice CM. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature. 2011;472:481–5.
Wang Z, Zhang A, Wan Y, Liu X, Qiu C, Xi X, Ren Y, Wang J, Dong Y, Bao M, et al. Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection. P Natl Acad Sci USA. 2014;111:769–74.
Weidner JM, Jiang D, Pan XB, Chang J, Block TM, Guo JT. Interferon-induced cell membrane proteins, IFITM3 and Tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. J Virol. 2010;84:12646–57.
Yang X, Tan B, Zhou X, Xue J, Zhang X, Wang P, Shao C, Li Y, Li C, Xia H, et al. Interferon-inducible Transmembrane protein 3 genetic variant rs12252 and influenza susceptibility and severity: a meta-analysis. PLoS One. 2015;10:e0124985.
Yount JS, Moltedo B, Yang Y-Y, Charron G, Moran TM, López CB, Hang HC. Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3. Nat Chem Biol. 2010;6:610–4.
Zhang YH, Zhao Y, Li N, Peng YC, Giannoulatou E, Jin RH, Yan HP, Wu H, Liu JH, Liu N, et al. Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nat Commun. 2013;4:1418.
The authors would like to thank Dr. Amin Doosti Irani for his valuable consultation in statistical analysis.
This study was funded by National Elites Foundation, Iran (grant number 831).
Availability of data and materials
All data in case of need are available.
Clinical investigation was conducted according to the principles expressed in the Declaration of Pasteur Institute of IRAN. This research was reviewed and approved by the Ethics Committee of Pasteur Institute of IRAN (Protocol Number IR.PII.REC.1395.3).
Consent for publication
Written informed consent was obtained from the patients or the guardians of the patients participated in this research.
Authors (Parvaneh Mehrbod, Sana Eybpoosh, Fatemeh Fotouhi, Hadis Shokouhi, Vahideh Mazaheri, Behrokh Farahmand) declare that they have no conflicts of interest.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Multivariable logistic regression of the association between IFITM3 rs12252 polymorphisms and mild flu in an Iranian sample with Fars ethnic background: Intermediate results. (DOCX 16 kb)
Univariable and multivariable logistic regression of the association between mild flu and IFITM3 rs12252 polymorphisms, BMI, diabetes, and hypercholesterolemia in an Iranian sample with Fars ethnic background: observed powers. (DOCX 20 kb)
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Cite this article
Mehrbod, P., Eybpoosh, S., Fotouhi, F. et al. Association of IFITM3 rs12252 polymorphisms, BMI, diabetes, and hypercholesterolemia with mild flu in an Iranian population. Virol J 14, 218 (2017). https://doi.org/10.1186/s12985-017-0884-4
- Human influenza
- IFITM3 protein
- Body mass index

domain: literature


King Charles III coronation details revealed by Palace
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King Charles will “take the moral high ground” when deciding whether the Duke and Duchess of Sussex and Prince Andrew should be part of the historic balcony appearance scheduled for moments after his coronation, a royal commentator has claimed. The possibility of Prince Harry and Meghan’s attendance at the coronation has become a hotly debated topic after the royal’s recent memoir revealed striking personal details about the family and criticised the Firm.
Prince Andrew has also stepped back from royal duties after allegations of sexual abuse which the Queen’s son has strongly denied. Daily Express’ royal correspondent Richard Palmer predicted Andrew and the Sussexes would be invited to the coronation – but, crucially, not onto the balcony.
During Express.co.uk’s Royal Round Up, he told Pandora Forsyth: “My guess is the King will take the moral high ground, whatever the state of his relationships with the Sussexes and his brother Andrew at that point, and invite them all to the coronation.”
However, the new monarch was likely to follow in his mother’s footsteps when it came to establishing who would appear with the senior members of the family in Buckingham Palace after the big event, Mr Palmer predicted.
The Queen specifically designated the spots for royals who were actively working – which precludes the appearance of both Andrew and the Sussexes, with the former having to take a backseat following the scandal in his personal life and the latter choosing to revoke their roles in the family.
He explained: “We saw at the Platinum jubilee the Queen break with the order of precedence in the seating arrangements at St Paul’s Cathedral, where the working royals were given precedence.
“They were given front row seats, and the Sussexes and those who don’t have official duties were relegated to seats behind. That would be my guess for how things will work this time round. I don’t believe that there will be a place for the Sussexes or the Duke of York on the balcony.”
The King has maintained silence in response to the claims made by Prince Harry and Meghan across their various media appearances – with the strategy being no different regarding what Mr Palmer described as the “thorny question” of the balcony appearance.
Kensington and Buckingham Palace have refused to comment on anything contained in Harry’s book, which is in keeping with their maxim of “never complain, never explain” and not sharing their opinions, leaving official communications to speak out on matters.
Historian David Starkey has described King Charles III’s silence towards his son as a “clever long game”.
He told The Mirror: “What I think Charles is doing is actually playing a rather clever long game. He’s just letting events take their course, which I think is a very wise thing to do.”
In a poll that ran from 11am on Tuesday, January 3rd to 1.30pm on Friday, January 6, Express.co.uk asked readers: “Is it time for Royal Family to speak out ahead of next ‘explosive’ Harry interview?” – to which the overwhelming majority (78 percent, or 4,706 people) responded “No.”
Meghan’s biographer Omid Scobie attacked the family for their silence, however, writing for Yahoo!: “While it may be true that Buckingham Palace and Kensington Palace have chosen not to answer requests for comment from journalists (including myself) about the revelations in Spare, in my experience of royal reporting the reality of the institution’s silence might not be quite what it seems. Despite the tired ‘never complain, never explain’ facade, an assortment of Royal Family sources and friends have all been busy speaking to media outlets since the contents of the book first leaked to British newspapers ahead of its 10 January debut.
DON’T MISS: Meghan did not ‘cast a spell’ on Harry, says royal biographer [REVEAL]
Prince Andrew ousted from swanky Buckingham Palace apartment by King [INSIGHT]
Charlotte could get unique royal title due to King’s ‘change of heart’ [ANALYSIS]
“Whilst these sources may be speaking out entirely independently, given how tight knit the Royal Family inner circle is, I doubt they would speak to the media without at least some form of tacit approval from the royals.”
But Mr Scobie admitted the “silence” from the Royal Family over the claims from Harry “seems to be working”. In an interview with CBS’ Anderson Cooper, Prince Harry said: “at some point silence becomes betrayal.”
He was not clear about whether he would want to attend the coronation if he was invited, however, saying: “There’s a lot that can happen between now and then. But you know, the door is always open. The ball is in their court.
“There is a lot to be discussed and I really hope that they are willing to sit down and talk about it.”
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FFBC GENERAL MEETING MINUTES
- New race team board for 2017. September/October race team results.
- Ride calendar moves to Google calendar.
- Bicycle Education Committee Chair, Wynn Kageyama will educate the local community on bicycle safety and provide simple bicycle repairs.
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domain: hobby


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“My contention is that creativity now is as important in education as literacy, and we should treat it with the same status”
Sir Ken Robinson
Our Arts Curriculum nurtures, encourages and builds on creativity, ensuring that our children have the opportunity to be taught the skills of creative subjects which have so often been squeezed out of the Primary Curriculum. Music, Art, Drama, Dance, Musical Theatre and Design Technology will be taught as specific subjects by qualified specialists during the afternoons, as well as being integrated into the Primary Curriculum.
We are a Music Mark school which means our commitment to providing a high-quality music education has been recognised by the UK Association for Music Education.
Music is a valued subject at RAPS as it helps children express themselves, connect to other cultures and understand the world around them. Every child in the school will take part in a music programme where children will be taught specific musical skills including singing, playing instruments, theory, history and performance. There will be formal music lessons each week based on the National Curriculum programmes of study and as they pass through Key Stage 2, every child will be offered the opportunity to learn to play an instrument. We offer pupils the opportunity to take up extracurricular lessons in piano, violin, guitar, drums, vocal and ukulele. We also offer rock band lessons (through Rocksteady Music).
Drama is an art form, a practical activity and an intellectual discipline. At Ramsgate Arts Primary School, drama begins naturally with learning through dramatic play in our Early Years and Key Stage 1 where they may begin to explore their learning in other areas of the curriculum through drama. In Key Stage Two, drama is taught by subject specialists as part of the arts curriculum where children may explore their core texts in English through drama and work on specific skills and dramatic techniques which are progressively taught and assessed, whilst building upon previous learning. Three interrelated activities characterise the subject of drama at all levels: devising, performing and responding.
In dance, children learn and develop many skills; learning the value of discipline, commitment and work ethic, as well as creative thinking skills. Self-confidence develops as children overcome challenges to master new goals, learning to apply themselves and accomplish any task put before them. Dance teaches children about music, rhythm and beat. Children will have a better understanding of spatial relationships and learn to think with both sides of their brain. All these skills enhance a child’s academic performance, as well as their physical well-being. Dance is taught from Reception to Year Six by industry professionals in order for children to get the best dance education.
Art and Design
Through our partnership with the Turner Contemporary, children at Ramsgate Arts Primary School will have many opportunities to experience Art and Design to understand what it is that artists, designers and craftworkers do, and to develop their own confidence in using media and techniques. Where possible, art is linked with their learning in topic to create a fully cohesive curriculum. Children will also work with a range of media and be exposed to a variety of artists, past and present, from around the world.
Art and Design activities will encourage our RAPS artists to:
- respond to the world around them;
- respond to their individual feelings and emotions;
- develop and use their imagination;
- express their ideas, thoughts and feelings;
- solve problems;
- become more aesthetically aware.


I’ve been making the assumption that the normal and intrinsic curves for AlNiCo magnets are (virtually) the same. I have never seen a second quadrant B/H curve for AlNiCo that has both (unless they are indeed one in the same). Properties for Hc and Hci are the same as listed in the data sheets. Is my assumption correct? And if so, why? When designing a motor in FEA with AlNiCo I’ve described the non-linear curve in the properties rather than just an Hc and relative permeability. Does this sound right? Not much call for AlNiCo in motors these days, coreless low inertia DC motors were always AlNiCo (very thick due to easy Demag).
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Keep It Real.
On The Clock.
belizeans took a massive L with this yuth ya
"Kidd Kidd was released from jail today after spending nearly a week on Rikers Island. Kidd was arrested outside of the Best Buy Theater last week for allegedly attacking his girlfriend
RapRadar some fools for this one. Lolololo WTF does that say Tony Yayo? Him and Kidd Kidd dating now?
NOW THAT'S WHAT YOU CALL JOURNALISM!!!! NOT SOME HIRED BASIC FUCKBOY BLOGGER ON A RAP SITE THAT WRITES ABOUT THE OBVIOUS!!!! Kidd Kidd was released from jail today.....WELL NO FUCKIN' DUH!!!! LMAO!!!!
DON'T HATE ON MY OPINION!!!!
Kidd Kidd has been released from prison after posting a total of $105,000 in bail today (July 6). The 2015 XXL Freshman posted $5,000 bond for his New York case in criminal court. He also posted $100,000 bond after appearing in Supreme Court in front of the Judge Larry Stephen. Stephen instructed Kidd Kidd that he has to turn himself in to New Orleans police by Thursday end of day. He was released right from the courtroom following the hearing and arrangements are being made for him to turn himself into NOLA authorities.
"my most loyalist thang gave ya boy the clap" lmaooo


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If you fancy sprucing yours up for autumn/winter, the stylish folk at Delcor are here to help. Take note of their top tips and get snug!
Add texture, colour and layers with knitted blankets and throws. Oversized chunky knits will keep you toasty and they can be easily changed to suit the season and your decor. Layering is good, too, so invest in several, all differing in materials and colours so they complement each other. If your sofa is patterned, then go for single colours.
Forget grey and white this winter; it’s all about the colour. Add a touch of opulence and create a bold palette with rich, deep tones for the new season. Blues, forest green and brick red work well, either on their own or grouped together. Top prints for AW19 include orals, tropical and lavish thematic scenes. Opt for wallpaper, or be brave and invest in a statement sofa, chair or footstool.
Set the mood with dimmable lights and lamps – both of which create soft, cosy lighting. Brass, bronze and glass lamps, tables and mirrors cleverly bounce the light around a room, making it twinkle on a winter’s night and creating the feeling of warmth. Make your mirror a focal point in your living room and go as large as the room can take, being creative with placing. Large, floor-standing mirrors are set to be popular in living rooms come the new season.
Aside from the bedroom, the living room should be the most comfortable room in your home – especially during the chillier months. Soft velvets and warm merino wool provide a luxurious touch to upholstered pieces and soft furnishings. Delicately-soft nubuck leather is one of our go-to textures. Warm things up with fluffy cushions and patterned throws to create an inviting, seasonal look.


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That light at the end of the winter tunnel? It’s Spring Break. While Spring Break is undoubtedly a great getaway after the holidays, it can also become a logistics nightmare. Whether you like it or not, pretty much everyone else has the same idea during the 2019 calendar season. Spring breakers are either traveling home […]
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The holidays make for one of the busiest travel seasons in the U.S. as Americans trek to destinations all over the country to be home for the holidays. But traveling during the holidays doesn’t have to turn you into a Grinch. With a little planning and the right attitude, you can survive any crowded airport […]
If you ever need a place to relax during your layover, airport lounges provide all the comfort and convenience a traveler desires. The serene atmosphere and cozy ambiance inside the lounges will make you forget all about the noisy, bustling, crowded airport terminals and bring you into a state of tranquility that’s hard to match. […]
The best part of vacation is the destination. You’ve spent hours online researching the beach, the mountains, the lake, or the canyon. You have the perfect hotel. You have just the right rental car and the perfect travel companions. The worst part of vacation? Getting there. An airport lounge can change that experience. What’s provided […]


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Born and raised in the Tampa Bay area, Capt. Rick grew up fishing the flats, beaches, creeks, & rivers that make up this amazing estuary. He fell in love with fishing the West Coast of Florida and to this day, he loves going fishing — whether it’s with his clients or his family.
If you are looking for an experienced captain who has a passion for fishing, you’ve come to the right place. Capt. Rick is a pleasure to fish with and he can show you the trip of a lifetime.


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Changing the main page in Joomla can be done in a few simple steps. First, open up the main page in Joomla and locate the “Main Page” tab. On this tab, you will see a list of main page options. Next, select the option you would like to change.
This might be the “Title”, “Description”, or “Description 2”. After you have made your selection, click on the “Change” button to bring up the changes page. Here, you will have the opportunity to enter a new title, description, or both. Finally, click on the “Save Changes” button to save your changes.


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- Is PUBG Mobile Lite is offline?
- Is Shadow Fight 2 an offline game?
- Is PUBG online game or offline?
- Is Badlanders an offline game?
- Is online games good or bad?
- Are free online games safe?
- What is online games addiction?
- Is free fire an offline game?
- Is PUBG banned in India?
- Is Badlanders a battle royale game?
- Can life after be played offline?
- How do I play games on the Internet?
- How many GB is life after?
Is PUBG Mobile Lite is offline?
PUBG Mobile Lite is a famous battle royale game that is a lighter, more compact version of PUBG Mobile.
It has low system requirements and is compatible with both high and low-end devices.
Interestingly, there are many offline BR games that you can play in your Android device..
Is Shadow Fight 2 an offline game?
If you haven’t already, try Shadow Fight 2. It can be played offline (except duels and raids).
Is PUBG online game or offline?
7. PUBG Mobile is an online free game, and an internet connection is mandatory to load data, so without the Internet, you won’t be able to launch the app to play in other modes.
Is Badlanders an offline game?
Appdroid.ws – Badlanders (Online/Offline) Android Size 527… | Facebook.
Is online games good or bad?
It’s true that some studies have shown certain video games can improve hand–eye coordination, problem-solving skills, and the mind’s ability to process information. But too much video game playing may cause problems. … A good game will be the right one for how old you are.
Are free online games safe?
Playing free online games will not get you any malware if you are playing them on a reputable site. If you are searching around for another game website, there is no telling what you will find.
What is online games addiction?
Video game addiction, also known as gaming disorder or internet gaming disorder, is generally defined as the problematic, compulsive use of video games that results in significant impairment to an individual’s ability to function in various life domains over a prolonged period of time.
Is free fire an offline game?
Garena Free Fire game Needs an internet connection as it is not an offline game. It is online multiplayer survival battleground mobile video games .
Is PUBG banned in India?
India banned PUBG this year under Section 69A of the Information Technology Act. The Government of India said the PUBG Mobile Application was engaged in activities that are prejudicial to sovereignty and integrity, defence and security of the country.
Is Badlanders a battle royale game?
#1 Badlanders: One of the best games in the battle royale genre for players who love action-packed gameplay is the Badlanders. Players can learn the game’s shooting mechanics quickly and take on their rivals on the battlefield.
Can life after be played offline?
Since the launch of LifeAfter, players have grown together by chasing hope and light at this in-game postapocalyptic world. Thanks to the ever optimizing “Doomsday” experience and the extremely engaged player community, LifeAfter is able to jump across the barrier that separates online from offline.
How do I play games on the Internet?
How do I get into a game?Boot up your game and sign into your account.Locate the multiplayer option on the start screen.Choose your preferred settings (i.e., 5v5 or 10v10 player match), and you’re on your way.
How many GB is life after?
Storage: 5 GB available space.

domain: entertainment