text:
My aim in life is to become a successful medical professional. I have an immense passion for the medical field, and I strongly believe that with hard work, dedication, and the right guidance, I can achieve success.
My primary aim is to become a well-qualified doctor who would be able to help people in times of need. I am aware that I must acquire a broad range of skills, and I am already studying diligently to increase my knowledge base.
I am currently enrolled in a medical school to gain the necessary expertise and become aware of the exact methods of providing medical aid.
I also have certain values that I never plan to abandon on behalf of my ambition.
I believe in empathy and sympathy towards the ill patients, and I consider it my duty to make them feel at ease by investing my time and efforts to assess their condition.
Moreover, I have holistic and humane approach towards patient care and try to provide a satisfactory experience to everyone.
I strive to practice more efficient and modern techniques, and I always keep myself updated with the latest advancements in the medical field.
Furthermore, I strongly believe in the values of teamwork and collaboration and do not plan to practice individually. I understand that team effort is more fruitful and effective for the purpose of providing better medical services.
I always take others’ opinions seriously and respect the opinions of the peers and seniors.
I am well aware of the responsibilities that come with this profession, and I am ready to accept them.
I am hopeful that, with the help of my dedication and hard work, I would become successful in achieving my ambition of becoming a quality doctor with a leading hospital.
I am confident that one day I will become a successful medical professional and it will eventually fulfill the purpose behind choosing this profession.


Companies that develop VR or any form of STEM simulations usually employ Engines that were developed to create video games. This results in long development times and high development costs. At PNX Labs we created Nexus, our own proprietary IDE environment to speed the development of STEM simulations specifically. Our platform allows us to develop STEM simulations in times as little as 2 days and up to 70% lower development costs.
Our simulations platform has over 10,000 functions and pre build algorithms to ensure we can deliver a fast development experience to our customers. Once the information is submitted and the project is approved we will start to work on the simulations. The customer can see in real time how the project is progressing, test the simulations before completed and more.
Our Virtual Labs come packed with academic content and real world applications which allow students to experience a true learning experience in a hazard free environment. We have partner with leading technology companies in the world to provide a complete package of learning tools which were impossible before without recurring to high cost solutions.
At PNX Labs we work extensively with the industry to provide the best solutions for STEM education and Industrial Virtualizations. By using our proprietary platform we are able to create complex science and engineering simulations to allow companies to improve current engineering processes, train personnel and increase productivity.
At PNX Labs we have partner with leading companies around the world to provide high quality academic content for institutions of higher education. But our potential goes beyond that. Our technology can also be applied for the corporate sector.
By Providing full integrated Virtual Labs companies can train personnel more efficiently, gain a better understanding of large scale projects and better engineered products. Our Virtual Labs come equipped for:
- Real manufacturing simulations
- Statistical Data for Quality Management
- Added custom functions and applications for inspection, engineering and planning
- Fully customized for any industry
- Astonishing graphics for a real experience
Depending on each use case which is defined with the customer we can develop applications for one or more platforms at a very competitive cost.Our Technology allows us to develop for multiple platforms at a fraction of the cost thanks to our Science and Engineering algorithms and pre-build STEM functions. We can develop for Android, IOS, Web, Windows, Mac, Linux and Virtual Reality. For Virtual Reality we support the Oculus Rift, Oculus Quest, Oculus Go, HTC Vive and More.


text:
Teething is one of the toughest stages for parents, even though for babies as well. Parents frequently think that their little ones are teething, while they start putting their fingers in their mouth and drooling when they become four or six months old. The teething process will continue until the baby gets three years old. During the time of the teething process, there are some signs that indicate parents to be careful and give them a feeling of comfort.
Here we have a list some of the most common symptoms of baby teething can include:
- Facial rash
- Ear rubbing
- Gum rubbing
- Biting and gnawing
- Disrupted sleep
- Low-grade fever
- Loss of appetite
- Swollen and inflamed gums
Every infant experience differently when teeth start to erupt. Some babies have virtually no symptoms; on the other hand, some babies suffer through the fussiness pain of teething for several months. However, if parents will become aware of the symptoms of teething, so they are able to alleviate pain easily at the time of teething through various home remedies.
The Best Teething Remedies
The parent can help alleviate their babies teething discomfort with theses home-made and mom-tested remedies:
Cold Bottle of Water
A bottle of chilled water can provide instant relief to itchy as well as achy gums for infants over six months. If your baby does not take a bottle then you can give them water in a cup without ice. It will also help to soothe the pain of teething.
In the process of teething infants love to chew, because it provides the pressure on gums, which soothe the aching of teething. Rubber teething rattles, rings, other soft toys can also work well in order to soothe the pain. You can also give your baby frozen fruits to chew the cold sensation will numb the pain of gums.
If rubbing, sucking, and chewing cold foods doesn’t work. Take your baby to the pediatrician dentist. The dentist will examine and provide appropriate treatment in order to relieve your baby from discomfort.
Don’t Use Teething Necklace
There is no medical proof to suggest that amber teething necklace works; the majority of the pediatric dentist is advised not to use or avoid it. Because this necklace has a risk choke. There are many home-made remedies through them; you can help your baby in the process of teething. At the time your baby’s initial tooth erupts, you need to consult to the pediatric dentist in order to get further guidance.

domain: medical


text:
Pauline Hanson is not backing down on her call for a royal commission into Islam and a ban on new mosques, however it will not be her first priority once in Canberra.
Ms Hanson has resurrected her political career and is expected to secure a Senate spot for Queensland, and believes her One Nation party could pick up others in NSW and Western Australia.
Near her party headquarters in Brisbane, Ms Hanson said her first priority was a royal commission into the banking sector and "cleaning up" the family law court.
She said she was "not sold" on climate change, would prefer a "referendum rather than a plebiscite" on gay marriage, and was "very, very" against the sale of Kidman station, and foreign ownership generally.
Ms Hanson also wants zero-net immigration, so the number of people coming to Australia equals the number leaving, and a royal commission into Islam.
"You have our values, culture and way of life, you don't have a full burka," she said.
"You don't keep putting up mosques. You cannot deny the fact that in these mosques they have been known to preach hate towards us.
"Do you want to see terrorism on the streets here?
"I'm not preaching hate, I'm trying to have a debate and a royal inquiry into it.
"You're having a go at me, because I stand up for my culture, my country, and way of life."
It has been two decades since she served as an independent in the Lower House, and her agenda appears just as controversial, so much so that she is concerned for her safety.
"Yes, I am always, of course, but sometimes you have to stand up for what you believe," she said.
"That's why I think maybe some of the other members of parliament have not taken a stance against this."
Islamic Council of Queensland spokesman Ali Kadri said he viewed Ms Hanson's rhetoric as hateful.
"Pauline is a danger to our country, with her rhetoric and her divisive views ... and it's not just about Muslims. I mean, 20 years ago it was Asians who were going to swamp us and now it's about Muslims and it will be about everybody else who doesn't look like Pauline," Mr Kadri said.
He offered to sit down with Ms Hanson to talk through any specific problems she has with Muslims.
'Swamped by Asians'
After making headlines during her 1996 maiden speech to parliament, Ms Hanson again raised fears over immigration levels.
"You go and ask a lot of people in Sydney, at Hurstville, or some of the other suburbs, they feel they have been swamped by Asians," she said.
"A lot of Australians feel that Asians are buying up prime agricultural land, housing, you ask the people in Melbourne how they feel about it as well.
"As far as work, increased immigration is not the answer to creating jobs in Australia.
"The 457 visa-holders, we need to address that, the numbers that are coming into Australia."
No call from Turnbull, Shorten, but 'happy to work together'
Whichever party forms government will have to embark on Senate negotiations with Ms Hanson.
Ms Hanson said Attorney-General George Brandis had reached out to her on behalf of the Liberal National Party (LNP), but she was yet to get a call from Malcolm Turnbull or Bill Shorten for support in what could be a hung parliament.
"To tell you the truth, I don't particularly like either of them," she said.
"If either of them are going to be prime minister I am quite happy to work with them.
"The people are fed up with seeing a dysfunctional parliament and the antics that go on are not what the people want or need.
"I think this time around, because I'm not politically naive, I'm older and I think I'm wiser with this and I haven't got the people around me who are out for their own self-interest or gains."
Amid the electorate success federally, Ms Hanson is setting sights on the next Queensland election.
"I will be targeting the next Queensland state election and I'm hoping to be able to stand a candidate in every seat in the next state election," she said.
In Queensland, One Nation got 9.16 per cent of the vote for the Senate on first preferences.
That is compared to 33.68 per cent for the LNP, 27.22 per cent for Labor, 7.57 per cent for the Greens and 2.58 per cent for the Liberal Democrats.

domain: sociology


text:
XB-ART-59753Genomics 2023 May 01;1153:110630. doi: 10.1016/j.ygeno.2023.110630.
Show Gene links Show Anatomy links
Identification of rare loss-of-function variants in FAM3B associated with non-syndromic orofacial clefts.
Orofacial clefts (OFCs) are the most common congenital craniofacial disorders and cause serious problems with the appearance, orofacial function and mental health of the patients. The fibroblast growth factor (FGF) signaling pathway is critical for several aspects of craniofacial development and loss-of-function mutations of coding genes for multiple FGFs and FGFRs can lead to OFCs. We recently characterized FAM3B as a novel ligand of FGF signaling, which, through binding to FGFRs and activating downstream ERK, regulates craniofacial development in Xenopus. In this study, we identify two rare variants in FAM3B (p.Q61R and p.D128G) via target region sequencing of FAM3B on 144 unrelated sporadic patients with non-syndromic OFCs (NSOFCs). Bioinformatic analysis predict that these two variants are likely to be damaging and biochemical experiments show that these two variants weaken the FGF ligand activity of FAM3B by decreasing its expression and thus secretion. In summary, our results indicate that FAM3B is a novel candidate gene for NSOFCs in humans.
PubMed ID: 37105387
Article link: Genomics
Species referenced: Xenopus
Genes referenced: fam3b tbl1x
GO keywords: Wnt signaling pathway
Article Images: [+] show captions
|Fig. 1. Identification of rare loss-of-function variants (p.Q61R and p.D128G) in FAM3B associated with non-syndromic orofacial clefts. (A-B) Identification of p.Q61R and p.D128G variant in FAM3B gene in two unrelated patients with NSOFCs. Sanger sequencing chromatograms of mutated loci are labeled with arrow. (C) Location of FAM3B variants in the transcript (top) and protein (below). UTR: untranslated region; SP: signal peptide.|
|Fig. 2. In silico prediction of the pathogenicity of p.Q61R and p.D128G variants of FAM3B. (A) Frequencies of p.Q61R and p.D128G of FAM3B gene in databases of general populations. (B) Predicted pathogenicity of p.Q61R and p.D128G variant of FAM3B by various bioinformatic softwares. (C) Alignment of FAM3B protein sequences among vertebrates showing the conservation of amino acids affected by patient missense alterations (arrow). (D) Human FAM3B protein structure predicted by AlphaFold (https://alphafold.ebi.ac.uk/) showing the hydrogen bonds (H-bond) formed by Q61 with K59 and D64 (left) and D128 with R107, Y130, E131 and N134 (right). The Q61 and D128 substitutions are likely to disrupt the hydrogen bonds and thus the protein structure. Dashed boxes indicate that Q61 and D128 locate at α-helix and flexible structure, respectively. (E) ACMG classification of p.Q61R and p.D128G variants.|
|Fig. 3. p.Q61R and p.D128G variants of FAM3B show impaired capacity to activate ERK. (A) Hela cells transfected with His-tagged wild-type or mutant FAM3B were serum starved for 24 h and harvested for immunoblotting with the indicated antibodies. TUBULIN served as a loading control, which was detected in cell lysate, but not medium. Note that p.Q61R and p.D128G variants of FAM3B display reduced expression and secretion. (B) A flow chart summarizing our research rationale.|


text:
I am a part of a Bloggers Group on Facebook called BLM – Bloggers Like Me . This group is filled with some of the most talented and positive women I have ever encountered. In the three weeks that I have been with the group, i have gained so much more insight on the craft of blogging. That being said, I have decided to join in on a challenge from blogger Christa Myers @ http://www.inspiredbybeatriceclay.com/blog/. Follow me on Instagram at jayry2 to keep up.
31 Days Challenge

domain: artistic


text:
Hudson County wishes for 2013
Tuesday, January 01, 2013 10:57 AM
Inappropriate photo? Alert us.
"In the coming year, it is my hope that Congress comes together in a more bipartisan manner to tackle the issues facing our nation. Strict partisanship and a lack of compromise have not worked in the 112th Congress. Too many times Congress has waited to come to a 'deal' on policies affecting our economy, leaving the markets and American people at unease. In 2013, we must come together to ensure continued economic growth and job creation. An easy way to boost our economy and create immediate jobs is to invest in our infrastructure. Rebuilding smarter and stronger will not only create jobs now, but will potentially save money in the future by preventing further destruction as a result of natural disasters, like what we saw with Hurricane Sandy. I would also like to see immigration reform on the Congressional agenda this year. It is long overdue that we overhaul our immigration system and make it work for the people who want to properly come to our shores. Furthermore, after the horrific tragedy of Newtown, Conn., Congress must have the courage to stand up to the big-gun lobby and adopt sensible gun control reform.'' -- U.S. Rep. Albio Sires, D-West New York

domain: news


text: It’s been some time now since we first heard about the new biopic on legendary rapper Tupac Shakur, titled All Eyez On Me, with the initial trailer having been released back last summer, and then a second offering just last September. While there’s no confirmed date yet on the film’s official release, we do know what it’s expected to hit screens in a matter of months. To help maintain anticipation (which won’t be hard for any 2Pac/hip hop fan), the film has released its third trailer that showcases new clips, most notably one that highlights Tupac–played by Demetrius Shipp, Jr.–meeting The Notorious B.I.G. for the first time. Enjoy the new trailer in the jump above, and keep an eye out for news on when we’ll all be able to watch the artist, poet and revolutionary in cinemas.

domain: entertainment


text:
Statement By Rev. Jesse L. Jackson, Sr.
Founder & President of the Rainbow/PUSH Coalition
The Reverend Jesse L. Jackson, Sr. today issued the following statement regarding the verdict in the alleged “loud thug music” killing of 17-year-old Jordan Davis in 2012.
Jackson said, “Even as our thoughts and prayers go out to the family of Jordan Davis in the loss of their son, we must continue to demand that justice be done for that family on behalf of their son. How a jury could reach the verdict of ‘guilty’ for three counts of attempted murder and then be unable to reach a verdict for actual murder when considering the same facts is puzzling and defies logic.
“Michael Dunn, the 47-year-old white perpetrator, will probably spend the rest of his life in prison because he was convicted on 4 of 5 counts, but justice was denied Jordan Davis and so a new trial is called for. The new trial should possibly try him for manslaughter instead of first-degree premeditated murder. There is also a question about the competence of State Attorney Angela Corey who has refused to address one of the central issues in both the Jordan Davis and the Trayvon Martin trials – the issue of race.
“This is the third recent case in Florida where the ‘stand your ground’ law has apparently complicated rather simple cases of murdering young black teenagers – Trayvon Martin being the other young African American murdered. By contrast, Marissa Alexander, an African American female whose husband had a history of domestic violence, fired a warning shot into the ceiling after her husband threatened her life and she could not use the ‘stand your ground’ law, was convicted and sentenced to 20 years in prison. Thankfully, because of public pressure, she will get a new trial. Race was central to all three trials yet Ms. Corey has been reluctant and has refused to bring the relevant issue of race into the two trials of Davis and Martin. It may be necessary to seek help from the U.S. Justice Department and the U.S. Civil Rights Commission should investigate the ‘stand your ground’ law and the surrounding circumstances all three of these trials.
“These instances of different standards of justice must not be allowed to stand. We seek equal protection under the law for all Americans. It is difficult to understand why Michael Dunn’s words and actions were not used in the trail. He had regularly used the “N” word at a neighbor’s house and had written racially incendiary letters from the jail. The States Attorney seems to be incompetent and should not be allowed to conduct the retrial,” Jackson concluded.


text: For the lovers and dreamers our 'Modern Romantic' dress is altogether playfully casual and elegantly chic. Featuring a wide scoop neckline, ? length sleeve, and unique graduated V hemline. The gathered elasticated waist accentuates the silhouette and ensures the perfect fit. The graduated hemline is cut higher at the sides into a V shape at the front and back, and is fully lined in nude stretch lining with a lace edge detail at the hem.

domain: design


text:
This week’s Free Stuff Fridays is sponsored by Christian Focus Publications and they are offering an excellent prize package. There will be five winners and each will win a stack of books. Those books fall into three categories:
Discipline in the Church
First up we have a book that has created a bit of stir, God Redeeming His Bride: A Handbook of Church Discipline by Robert Cheong. Many of us find church discipline very difficult, our culture detests it, but our culture is also very quick to spot when the church seems to turn a blind idea to Christians who don’t lead lives consistent with what they profess. This book comes from the authors’ years of experience and also interviews with over 30 pastors from a wide range of geographical and ecclesiastical backgrounds. It results in a book that is very practical – including sample letters to members who fall but also a strong Biblical basis that will make it an indispensable guide to church leaders and members alike.
Fellowship in the Church
Fellowship in church is more than just being friends or a good neighbour to fellow members. It needs to be Christ centred and from the Gospel in order for us to grow together spiritually. This is the message from The Life of God in the Soul of the Church: The Root and Fruit of Spiritual Fellowship by Thabiti Anyabwile, and it is as relevant today, in this world that yearns for real community but doesn’t know where to find it, as it has ever been.
Doctrine in the Church
We also have four new titles from the popular Christians Pocket Guide series. Baptism by Robert Letham, Christology by Mark Jones, Justification by Guy Waters and Sanctification by J. V. Fesko are the topics covered. These fantastic little books give you the basics on deep and critical subjects within the Church. They do so in a brief, easy to read format but remain remarkably profound, with the intention of igniting a desire to dig deeper on a subject that catches your interest. Getting these doctrines right will transform individuals and strengthen our churches and these books will be a perfect starting point in that effort.
Giveaway Rules: As soon as the winners have been chosen, all names and addresses will be immediately and permanently erased. Winners will be notified by email. The giveaway closes Saturday at noon.

domain: literature


FILE - Minister Kamel Al-Wazir
CAIRO - 22 January 2020: “Egypt is planning to implement a multi-purpose plant in Safaga Port (containers - general merchandise) at an estimated cost of $500 million,” Minister of Transport Kamel al-Wazir said Wednesday.
Wazir added in a statement that the plant is 6 km south of Safaga Port, with an area of 750,000 square meters, indicating that a 1,000-meter berth will be constructed to receive general cargo ships and containers.
This came during the participation of the Egyptian minister of transport in the UK-African Investment Forum, which is held in the British capital, London.
He added that the importance of the plant is based on the fact that the sea port of Safaga is considered the most important port for the African continent on the western coast of the Red Sea. This is in addition to its connection to a local road network that reaches Sudan through Hadraba land port, making this station, if implemented, of great economic importance for the region.
"Safaga port and the economic area of the Golden Triangle are located on the sea route of Road and Belt Initiative that extends through the South China Sea, the Indian Ocean and the Bab Al-Mandab strait to the Suez Canal. The initiative contributes to the export and import of factories’ products in Upper Egypt instead of transporting their containers through the ports of Lower Egypt and Ain Sokhna, which means that the port of Safaga is considered the main port serving the governorates of Upper Egypt,” he explained.
He stressed that the establishment of this plant will contribute to servicing exports and imports of raw materials and manufactured materials in the region, including devices, equipment and factory components to complete the giant development axis (Golden Triangle) in Upper Egypt and benefit from development projects in the North and Central, and South regions of Upper Egypt, link them to the port and attract investments in the fields of industry, logistics and storage.
"Safaga port is considered a main station on the international shipping line linking the Mediterranean and the Indian Ocean through the Red Sea,” he stated.


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Enjoy!!What's new in this version:Available In All CountrysBetter GameplayMusic Added to Game How big a score can you get? Challenge your mates to beat it. Features:-7 fun background tracks-an endless level that gets more challanging the longer you play-fun, gross sound effects-Facebook posting so you can share your score on your timelineThis game is not made or endorsed by .
- And you must avoid the obstacles! How to play : - Just tap tap tap and make the sleepy birds fly.
ALWAYS RIGHT, related to it's direction!Avoid walls, don't go beyond the screen and watch out for the traps! Just an endless journey through different rooms. +++++ Enjoy the game where the tide has been turned around in favour of the dragons. Tap to flap Flappy Swines wings to guide him through obstacles in the hospital as far as your luck and concentration allows.
Be careful don't hit the obstacles. The ladders open and close! A really fun guessing game with pictures to guess.
It is definitely the hardest flappy game you've played so far.
We hope you will enjoy playing this game and the addicting game play while you help the dragons gain and maintain the upper hand.
Owl caught a mouse and carries it home. What's new in this version:- Fixed issue with bomb animation that on devices running iOS 7.# Great action game going retro style, lots of fun and addictiveness! Take one of your super cool Ninjas and collect as many coins as you possible can to unlock new cool characters and new levels to play. Sea Monster to join the battle today!Features: Simple touch control that will be enjoyed by both the young and young at heart Numerous levels that will keep you engaged for hours A High Score board where you and your friends can track your awesome scores and check out who really is the Earths strongest hero Otherwise both cards will flip back over and you will get another try.
Are you still squeezing through the hurdles with birds? No! This time, lets catch the birds all!Familiar operation, revolutionary playing way: touch screen to control the trees and get all the birds into your pocket!What are you still waiting for! Lets go!Touch screen to control the trees and trap birds into fling through.


text:
|Latitude & Longitude (WGS84):||53° 23' 12'' North , 4° 20' 39'' West|
|Latitude & Longitude (decimal):||53.38694,-4.34444|
|UK National Grid Reference:||SH441904|
|Owned/operated by:||Anglesey Mining|
|Locality type:||Group of Mines|
|Köppen climate type:||Cfb : Temperate oceanic climate|
|Other/historical names associated with this locality:||Gwynedd;|
The type locality for anglesite, specimens were found ca. 1790-1800 when the mine worked the gossan. Specimens are generally rare and examples can now most commonly be seen in old museum collections. Large crystals of barite have also been recorded during this period, but do not appear to have been saved. Many of the other specimens listed are generally microscopic in nature, unprepossessing, or are disseminated within the ore.
Whilst there is some evidence that parts of Parys mountain had been subjected to Bronze age fire setting techniques and that the Romans had mined areas here for lead and copper, the mines were first recorded worked in Elizabethan times (ca. 1580). A map in the Public records office (PRO SP45/36 MPF11) shows the havens of Amlwch and Dulas and gives distances to the copper works locating them on the eastern side of Parys mountain.
The main phase of working began in 1761, with Parys Mountain rapidly becoming Europe's premier copper mine. The Great Lode, which contained an average of 3.5% copper, was discovered in 1768. Together with underground workings and its newly-started opencast, Mona mine also utilised the precipitation process. In 1772/3, large amounts of scrap iron were being transported from London to be used in Mona Mine's precipitation pits.
By 1770 the vein had been extended onto Parys farm land causing increasing bitter boundary disputes. As a consequence, the deposit was then worked jointly by two mines, Mona Mine in the east and Parys Mine in the west. However, arguments over boundaries continued for many years and in 1835 a court ruling gave 2000 square yards of Mona mine's land to Parys mine.
Whilst masses of copper to 30lbs were noted by Lentin in 1800, the subsequent exhaustion of easily won supplies led to a dramatic drop in production in both mines in the first decade of the 19th century. Although there was a resurgence in the 1820s when new lodes were discovered, by around 1830, many of the Mona mine's precipitation pits were abandoned.
In 1832/4 the Parys mine's North Discovery lode was found, which lasted until around 1840, after which most mining had finished, with many mine workers moving to the Drws y Coed mine in Snowdonia.
There was a further resurgence of mining ca. 1860, the Parys Mines Company making an estimated £400,000 profit between 1858-70, after which mining continued in decline until ca. 1890 when most mining had ceased.
In 1877 part of the lease at the western end of the deposit was sold to the Morfu Du mining company, who then worked the Morfa Du Mine (small, shallow, ill-defined workings - SH 432900) from 1881-1904 and raised 5783 tons of ore.
In 1899 the Mona and Parys mines were merged to form Mona and Parys mines Ltd. Activity was concentrated at the precipitation and ochre works.
It is estimated that between 1768-1904, a total of 3.5 million tons of ore were raised, producing 130,000 tons of copper and around 20km of underground workings were driven. Although large opencasts remain on the hill, there is remarkably little to be seen in the way of minerals.
Modern exploration commenced in 1955, initially by Anglesey Mining Exploration Ltd and then by the Anglesey Copper Mines (UK) Ltd, who, until 1962, drilled 11 boreholes. From 1966-70 the Canadian Industrial Gas and Oil Company Ltd ( CIGOL) drilled a further 52 bore holes without finding promising reserves.
In 1973, a high-grade polymetallic ore deposit was discovered by Cominco Ltd. Estimated reserves were 4.8 million tonnes of ore containing 1.5% copper, 3% lead, 6% Zinc, and small amounts of gold and silver.
In 1988, a new shaft (Morris shaft) was sunk by The Anglesey Mining Company. Reserves are now stated to be 7.8 million tonnes. In 2008, AMC began negotiations with Western Metals of Australia to purchase and develop the site, but the subsequent fall in world metal prices has left the future of mining here unresolved.
Of historical interest, Parys Mountain provided the copper sheathing for the hulls of warships of the British Navy, its fleet being completely coppered between 1778-82. The technique, developed in Britain, improved performance (and protected the hull from the ravages of the Teredo worm) and gave the British Navy important advantages over the French and Spanish fleets during the wars of the time.
The site has also featured as a location for a number of films including the cult UK Sci-Fi series, "Dr. Who".
NB: contemporaneous mining tokens (pictures shown within site photos) name the mining company as the Paris Mine.
Commodity ListThis is a list of exploitable or exploited mineral commodities recorded at this locality.
51 valid minerals. 1 (TL) - type locality of valid minerals.
Rock Types Recorded
Select Rock List TypeAlphabetical List Tree Diagram
Entries shown in red are rocks recorded for this region.
This geological map and associated information on rock units at or nearby to the coordinates given for this locality is based on relatively small scale geological maps provided by various national Geological Surveys. This does not necessarily represent the complete geology at this locality but it gives a background for the region in which it is found.
Click on geological units on the map for more information. Click here to view full-screen map on Macrostrat.org
419.2 - 443.8 Ma
|Unnamed Extrusive Rocks, Silurian|
443.8 - 485.4 Ma
|Paleozoic crystalline metamorphic rocks|
Age: Ordovician (443.8 - 485.4 Ma)
Reference: Chorlton, L.B. Generalized geology of the world: bedrock domains and major faults in GIS format: a small-scale world geology map with an extended geological attribute database. doi: 10.4095/223767. Geological Survey of Canada, Open File 5529.
541 - 4000 Ma

domain: history


Dryanovo, Bulgaria: One of the most beloved Bulgarian groups – B. T. R., will delight all residents and guests of Dryanovo with a concert on October 21, 2023 (Saturday).
Then will be the culmination of the program for the city holiday, which will begin with a grand opening on Petkovden – October 14. The rock stars’ concert will start at 6:30 pm in the square “The Largoto”. Local talents will appear on stage before them.
This year, the band celebrates 30 years on stage, and each of their participation is even more special. For those three decades B. T. R. they have released 13 albums, performed hundreds of concerts in the country and abroad, and many of their songs have become an integral part of the treasury of Bulgarian music and have been sung for generations.
Current lineup: Atanas Penev – vocals, Slavcho Nikolov – guitars and vocals, Ivan Kalfov – bass guitar and vocals, and Iliyan Dikov – drums, B. T. R. has established itself as one of the most essential rock groups in Bulgaria and has earned the respect of colleagues and the love of loyal fans, which continue to grow.
B. T. R. has performed on stage with legendary musicians and bands such as Deep Purple, Whitesnake, Scorpions, Ronnie James Dio – Heaven and Hell, Nazareth, Motorhead, Europe, Accept, Gamma Ray, Michael Schenker Group, Iron Maiden, etc.
The week from October 14 to 21 in Dryanovo will be full of events, including concerts, exhibitions, literary readings, hiking trips, “In the Kingdom of Wild Cycles” games and creative workshops for children.
Guests of Dryanovo will have more reasons to stay in the area besides viewing the architectural heritage of Master Kolyu Ficheto, the Dryanovo Monastery “St. Archangel Michael”, Bacho Kiro Cave and other sights.


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Katie, a 17-year-old, has been sheltered since childhood and confined to her house during the day by a rare disease that makes even the smallest amount of sunlight deadly. Fate intervenes when she meets Charlie and they embark on a summer romance.
Terry is a small-time car dealer trying to leave his shady past behind and start a family. Martine is a beautiful model from Terry's old neighbourhood who knows that Terry is no angel. When Martine proposes a foolproof plan to rob a bank, Terry recognises the danger but realises this may be the opportunity of a lifetime. As the resourceful band of thieves burrows its way into a safe-deposit vault at a Lloyds Bank, they quickly realise that, besides millions in riches, the boxes also contain secrets that implicate everyone from London's most notorious underworld gangsters to powerful government figures, and even the Royal Family. Although the heist makes headlines throughout Britain for several days, a government gag order eventually brings all reporting of the case to an immediate halt.
Orphaned and alone except for an uncle, Hugo Cabret lives in the walls of a train station in 1930s Paris. Hugo's job is to oil and maintain the station's clocks, but to him, his more important task is to protect a broken automaton and notebook left to him by his late father. Accompanied by the goddaughter of an embittered toy merchant, Hugo embarks on a quest to solve the mystery of the automaton and find a place he can call home.
Unhappy after his new baby sister displaces him, four-year-old Kun begins meeting people and pets from his family's history in their unique house in order to help him become the big brother he was meant to be.
Capturing John Lennon, Paul McCartney, George Harrison and Ringo Starr in their electrifying element, 'A Hard Day's Night' is a wildly irreverent journey through this pastiche of a day in the life of The Beatles during 1964. The band have to use all their guile and wit to avoid the pursuing fans and press to reach their scheduled television performance, in spite of Paul's troublemaking grandfather and Ringo's arrest.
In 1900, a clan attempts to strike a deal with a Chicago industrialist to get him to build cotton mills in their Deep South town.
Rome, 1957. A woman, Cabiria, is robbed and left to drown by her boyfriend, Giorgio. Rescued, she resumes her life and tries her best to find happiness in a cynical world. Even when she thinks her struggles are over and she has found happiness and contentment, things may not be what they seem.
After the enforced absence of their father, the three Waterbury children move with their mother to Yorkshire, where they find themselves involved in several unexpected dramas along the railway by their new home.
The true story of the frightening, lonely world of silence and darkness of 7-year-old Helen Keller who, since infancy, has never seen the sky, heard her mother's voice or expressed her innermost feelings. Then Annie Sullivan, a 20-year-old teacher from Boston, arrives. Having just recently regained her own sight, the no-nonsense Annie reaches out to Helen through the power of touch, the only tool they have in common, and leads her bold pupil on a miraculous journey from fear and isolation to happiness and light.
Qinawi, a physically challenged peddler who makes his living selling newspapers in the central Cairo train station, is obsessed with Hanuma, an attractive young woman who sells drinks. While she jokes with him about a possible relationship, she is actually in love with Abu Siri, a strong and respected porter at the station who is struggling to unionize his fellow workers to combat their boss' exploitative and abusive treatment.
A young married couple's relationship becomes strained when he is assigned overseas as a foreign correspondent and she becomes a major stage star.
Mickey is heading out on vacation from Burbank to Pomona, taking the train. The conductor, Pete, won't let him on with Pluto, so he hides Pluto in his suitcase, and tries to hide him all throughout the trip without much luck. But Pete wins when Pluto is hooked by a mail hook. Or does he?
Haruna Tsunematsu (Yuri Tsunematsu) is studying folklore at university and she decides the subject of her graduation thesis will be the "Kisaragi Station" urban legend which has been a hot topic on the Internet since 2004.
A detailed look at the gradual decline of Shenyang’s industrial Tiexi district, an area that was once a vibrant example of China’s socialist economy. But industry is changing, and the factories of Tiexi are closing. Director Wang Bing introduces us to some of the workers affected by the closures, and to their families.
An Irish artist, widowed by an IRA bombing, gradually learns that the American man she has become involved with is not who he seems.
Since the fall of the Iron Curtain an estimated four million children have found themselves living on the streets in the former countries of the Soviet Union. In the streets of Moscow alone there are over 30,000 surviving in this manner at the present time. The makers of the documentary film concentrated on a community of homeless children living hand to mouth in the Moscow train station Leningradsky. Eight-year-old Sasha, eleven-year-old Kristina, thirteen-year-old Misha and ten-year-old Andrej all dream of living in a communal home. They spend winter nights trying to stay warm by huddling together on hot water pipes and most of their days are spent begging. Andrej has found himself here because of disagreements with his family. Kristina was driven into this way of life by the hatred of her stepmother and twelve-year-old Roma by the regular beatings he received from his constantly drunk father. "When it is worst, we try to make money for food by prostitution," admits ...
Donald is the baggagemaster at a remote railway station. Part of the latest cargo shipment is Hortense the Ostrich, who is a bit too friendly with Donald, and who eats everything in sight, whether it's food or not (mostly not): a concertina, an alarm clock, some balloons, all of which start reacting when Hortense gets the hiccups.
Four passengers are stranded on a rainy night at a remote railway station. A serial killer is on the prowl in the waiting room creating panic. Will they nab the killer before it's too late?
A UK based NRI visit india, while returning goes to a remote station run by psychopath station master.


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Howdy peoples, this image is about Before Getting Into Too Many Details, Take A Look At This Quilt Sizes Chart! Quilt_Sizes_Infographic (amazing Crib Size Quilt #1). This attachment is a image/jpeg and the resolution of this picture is 768 x 1881. This photo's file size is only 85 KB. If You decided to download It to Your computer, you could Click here. You might also see more photos by clicking the image below or read more at this post: Crib Size Quilt.
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Interpretation of Before Getting Into Too Many Details, Take A Look At This Quilt Sizes Chart! Quilt_Sizes_Infographic
Intoin•to (in′to̅o̅; unstressed in′tŏŏ, -tə),USA pronunciation prep.
- to the inside of;
in toward: He walked into the room. The train chugged into the station.
- toward or in the direction of: going into town.
- to a point of contact with;
against: backed into a parked car.
- (used to indicate insertion or immersion in): plugged into the socket.
- (used to indicate entry, inclusion, or introduction in a place or condition): received into the church.
- to the state, condition, or form assumed or brought about: went into shock; lapsed into disrepair; translated into another language.
- to the occupation, action, possession, circumstance, or acceptance of: went into banking; coerced into complying.
- (used to indicate a continuing extent in time or space): lasted into the night; far into the distance.
- (used to indicate the number to be divided by another number): 2 into 20 equals 10.
- interested or absorbed in, esp. obsessively: She's into yoga and gardening.
- in debt to: I'm into him for ten dollars.
- pertaining to a function or map from one set to another set, the range of which is a proper subset of the second set, as the function f, from the set of all integers into the set of all perfect squares where f(x) = x2 for every integer.
Tootoo (to̅o̅),USA pronunciation adv.
- in addition;
moreover: young, clever, and rich too.
- to an excessive extent or degree;
beyond what is desirable, fitting, or right: too sick to travel.
- more, as specified, than should be: too near the fire.
- (used as an affirmative to contradict a negative statement): I am too!
very: She wasn't too pleased with his behavior.
- only too. See only (def. 5).
Atat1 (at; unstressed ət, it),USA pronunciation prep.
- (used to indicate a point or place occupied in space);
in, on, or near: to stand at the door; at the bottom of the barrel.
- (used to indicate a location or position, as in time, on a scale, or in order): at zero; at age 65; at the end; at the lowest point.
- (used to indicate presence or location): at home; at hand.
- (used to indicate amount, degree, or rate): at great speed; at high altitudes.
- (used to indicate a direction, goal, or objective);
toward: Aim at the mark. Look at that.
- (used to indicate occupation or involvement): at work; at play.
- (used to indicate a state or condition): at ease; at peace.
- (used to indicate a cause or source): She was annoyed at his stupidity.
- (used to indicate a method or manner): He spoke at length.
- (used to indicate relative quality or value): at one's best; at cost.
- be at (someone), to be sexually aggressive toward (a person): She's pregnant again because he's at her morning, noon, and night.
- where it's at, [Informal.]the place where the most interesting or exciting things happen: Emma says that Rome is definitely where it's at now.
Thisthis (ᵺis),USA pronunciation pron. and adj., pl.these (ᵺēz);USA pronunciation adv.
- (used to indicate a person, thing, idea, state, event, time, remark, etc., as present, near, just mentioned or pointed out, supposed to be understood, or by way of emphasis): This is my coat.
- (used to indicate one of two or more persons, things, etc., referring to the one nearer in place, time, or thought;
opposed to that): This is Liza and that is Amy.
- (used to indicate one of two or more persons, things, etc., implying a contrast or contradistinction;
opposed to that): I'd take that instead of this.
- what is about to follow: Now hear this! Watch this!
- with this, following this;
hereupon: With this, he threw down his glass and left the table.
- (used to indicate a person, place, thing, or degree as present, near, just indicated or mentioned, or as well-known or characteristic): These people are my friends. This problem has worried me for a long time.
- (used to indicate the nearer in time, place, or thought of two persons, things, etc.;
opposed to that).
- (used to imply mere contradistinction;
opposed to that).
- (used in place of an indefinite article for emphasis): I was walking down the street when I heard this explosion.
- (used with adjectives and adverbs of quantity or extent) to the extent or degree indicated: this far; this softly.
Quiltquilt (kwilt),USA pronunciation n.
- a coverlet for a bed, made of two layers of fabric with some soft substance, as wool or down, between them and stitched in patterns or tufted through all thicknesses in order to prevent the filling from shifting.
- anything quilted or resembling a quilt.
- a bedspread or counterpane, esp. a thick one.
- [Obs.]a mattress.
- to stitch together (two pieces of cloth and a soft interlining), usually in an ornamental pattern.
- to sew up between pieces of material.
- to pad or line with material.
- to make quilts or quilted work.
Sizessize1 (sīz),USA pronunciation n., v., sized, siz•ing.
- the spatial dimensions, proportions, magnitude, or bulk of anything: the size of a farm; the size of the fish you caught.
- considerable or great magnitude: to seek size rather than quality.
- one of a series of graduated measures for articles of manufacture or trade: children's sizes of shoes.
range: a fortune of great size.
- actual condition, circumstance, or state of affairs: That's about the size of it.
- a number of population or contents: What size is Springfield, Illinois? The size of that last shipment was only a dozen.
- [Obs.]a fixed standard of quality or quantity, as for food or drink.
- of a size, of the same or similar size: The two poodles are of a size.
- try on for size:
- to put on briefly in order to test the fit of, as a garment or shoes.
- to consider, evaluate, do, or use before taking further action: We'll try the plan on for size to see whether it's practical.
About the other-hand, recently we appreciate the classic household. Well, while you have heritage home parents that are historic, whynot decorate it to appear more elegant. Identity that was Before Getting Into Too Many Details, Take A Look At This Quilt Sizes Chart! Quilt_Sizes_Infographic (amazing Crib Size Quilt #1) already owned. How exactly to change it out to make it more modern and lucky that is clean that you simply possess a glass in the home, if granted the glass may be worth very costly. To become the main concentration lovely, select a natural shade paint for that surfaces around it.
- to separate or sort according to size.
- to make of a certain size.
- to press (a sintered compact) to close tolerances.
- [Obs.]to regulate or control according to a fixed standard.
- size up, [Informal.]
- to form an estimate of (a situation, person, etc.);
judge: They sized him up with a look.
- to meet a certain standard: He doesn't size up to my expectations.
Select wallpaper using a sample like the minimalist geometric forms.Usually there is a indentation across the screen within the old house should you prefer to utilize picture. So that you can remain revealed, placed drapes around the frame of the window sills. But Before Getting Into Too Many Details, Take A Look At This Quilt Sizes Chart! Quilt_Sizes_Infographic (amazing Crib Size Quilt #1) may decrease luxury and the visual in a tiny screen. Employ only curtains often, but created open. Another circumstance if you feel incredibly terrible shape window, then the drapes must be inserted outside the framework and address.
It may additionally incorporate with numerous previous dining table seats. Materials for example platforms garden / terrace, big potted plants also can complement the beauty of the inner of the house.The house that is old is not like a home nowadays. Space's split occasionally looks weird. As the bedroom is quite slim, eg so huge family area.
Use some things contained in even a vase of colorful bottles, the choice of elegant couch pillows, wallhangings model pop-art, or older residences, as an example, along with exchanging the display. Select which have variations of bolder colors, clear collections and structure. Blend both of these types in a single place. Eg change of furniture that is antique with furniture that's newer.
So will be the home that will be lengthy. Properly, you can work this around by switching characteristics or adding a Before Getting Into Too Many Details, Take A Look At This Quilt Sizes Chart! Quilt_Sizes_Infographic (amazing Crib Size Quilt #1) in a room that is too wide. Like a garage as well as bedroom, while half the living room used like all the home.
Drapery long before the underside also will produce an appearance more lavish inside. One of many items that might seem unpleasant is just about the shelves of old had started porous and aging. Exchange with open racks of lumber, may be solid wood or contaminants. Exhibit also vintage accessories you have. Available shelves will even supply a modern minimalist hint that old house doesn't seem like a gallery.
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What do you mean? Do you mean "Can I buy a home for $99 down in Colorado?" If so, I don't think so, and I don't agree with being able to do that, anyway. You need to have some "skin in the game" in order to purchase a home. If you cannot save enough money to have at least some down payment, then how can you expect to purchase a home, where at any given month, you don't have enough savings to cover an extra month's mortgage in case of emergency?
Sorry if that sounds harsh, but we need responsible folks purchasing homes so that we don't get in the same foreclosure mess again. I'd hate it if one of my clients purchased a home, had a hospital event, and therefore couldn't make payments, and then loses their home. We need to plan if we're purchasing a home!

domain: finance


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Hello Fellow Blues Lover,
I am writing to invite you to a special Night Of The Blues happening @ Evocal in Costa Mesa on Jan 31st.
My name is Robin Davey and I am a musician from the UK, I have had the fortunate opportunity to perform with many great names in the music world including Mick Jagger, Buddy Guy, Katy Perry, Indigenous and Dave Stewart of Eurythmics. However it is my time spent touring the world getting my blues education, appearing on stages alongside legendary figures like BB King, Jimmie Vaughan, Johnny Winter and Buddy Guy, that has always been my passion.
I am now currently residing in Southern California and although the various projects I currently work on sometimes take me away from my blues roots, I can't shake the bug and have to get out and play again. As a result I have put together an eclectic array of my closest musician friends to join me in providing a night of Blues entertainment which I hope will be the first of many.
I understand that in this time of financial hardships everyone suffers, so as an incentive to get people involved and out supporting live entertainment I wish to offer a special deal to all members of the meet-up group. If you email me your name before Jan 25th I will reserve your place and it will only cost you $3 to get in. Standard ticket price is only $5 for anyone else you want to bring with you.
The reason I am doing this is I want to be able to make the night of blues a regular occurrence and in order to do that I need to show the venues around the area that this is something local people want. In return I will always endeavor to put together a bill of varied and talented artists from all over the world for an evening of good time fun and keep the entry fee at a reasonable price.
To add your name to the $3 list please email your name to [address removed] we will also add you to our mailing list to receive info about future shows.
Also I would like to offer you the chance to download 4 Robin Davey Blues Mob tracks for free from my press kit site, again this is only available for a limited time to Meet Up members.
The other artists I have performing with me are:
Tony Brucco - Tony is an exceptional singer songwrtier and multi talented musician, his new album Dream Box is due out in the spring and is a Steamy mix of Blues, Americana and Bluegrass recalling the swampy overtones of Tom Waits and southern stomp of Dr John. Tony is going to both perform a set of his new material and also perform with The Blues Mob
Nadirah X - Nadirah is a Jamaican Hip Hop artist who won the Best New Female Artist in Jamaica 2002. She has recorded with Artists like Annie Lennox, Joss Stone, Jimmy Cliff and Mick Jagger said of her "She's The Real Deal".
Greta Valenti is the singer of Orange County favorites Fuji Minx. FM won the Best Alternative Pop Song award at the IAC music awards and album of the year from Bullz-Eye Magazine. They have been number 1 on the Indie Radio Charts for over a year.
The Address for the show is
Evocal 814 W 19th St, Costa Mesa Ca 92627
Thank you for taking the time to read this


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These five ingredient recipes make it easy to get dinner on the table fast. But just because these 5 ingredient recipes don't have a long list of ingredients doesn't mean they aren't tasty. They are! So make one of these five ingredient recipes tonight, and let me know what you think of it.
01 of 10
Oven Baked BBQ Chicken Recipe
This sweet and tangy barbecue chicken recipe is a cinch to prepare. Serve this five ingredient recipe with red potato salad and Ramen noodle cole slaw.
02 of 10
03 of 10
04 of 10
Sour Cream Chicken Enchiladas Recipe
These flavorful enchiladas are made with rotisserie chicken breast and store-bought salsa, for a fast and easy dish that tastes like it came from a restaurant. Use the best-quality salsa you can find for this easy five-ingredient recipe.Continue to 5 of 10 below.
05 of 10
This is one of those five-ingredient recipes that looks a lot harder to prepare than it is. In fact, it couldn't be simpler. Even kids can make this recipe. And with the sweetness of the honey, plus the richness of the butter combined with the crunch of the topping, this salmon recipe is a guaranteed winner.
06 of 10
07 of 10
Even though salt and pepper are integral ingredients for this 5 ingredient recipe, I don't count them (gotta have some rules, right?). You can make this baked chicken recipe with breasts, but I think it's juicier with chicken thighs.
08 of 10
Tater Tot Casserole Recipe
This is one of those five ingredient recipes that's guaranteed to be a hit with the kids. You can up the nutritional value of this dish by stirring in some frozen peas and carrots.Continue to 9 of 10 below.
09 of 10
10 of 10
Fish is topped with a crunchy cornflake crust in this kid-pleasing five ingredient recipe.

domain: food


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Discover our titanium diamond pendant for men, a modern and masculine design wich combines titanium with diamond. Lightness, resistance and power…The Move Titanium pendant can’t be unnoticed. Brushed steel, ultra-light chain in titanium, a second skin jewel… The modern and masculine version of the Move jewel to wear day to day the signature of a style. Let be seduced by our titanium diamond pendant for men and explore online Messika’s unique jewelry collection for men!
Reference: Move Titanium white diamond pendant 6717
Diamond weight: 0,08 carat, quality G/VS
Length of chain : 68cm (3 retaining rings)
Length of the pattern: 41mm
Width of the pattern: 1mm
The Move Titanium white diamond pendant is also available in Total Black and Graphite versions.


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Growing frustration over processors not passing back supposed market returns is symptomatic of the lack of trust which exists between farmers and those further up the chain.
With spot prices in the dairy market continuing to increase, many milk producers feel they should be seeing more of a return at farmgate level as they look to rebuild bank balances battered by months of downturn.
Some farmers even told me a few months ago of their belief the milk price would be 30ppl by Christmas as demand fell short. There might be more chance of seeing a real life Santa Claus drop down the chimney than that happening.
As prices continue to stutter, talk in Northern Ireland has turned to withholding supply as Farmers For Action looks to make its members kingmakers in the festive supply and demand equation.
Fundamentally, if farmers trusted processors to do the right thing by them in the first place there would be no need for the industry and unions to be ramping up the tension and threats of what could happen.
But is it any wonder the whole industry suffers from a lack of trust when, to use the red meat sector as an example, one of 2 Sisters’ top men is on record as saying the only thing farmers respond to are penalties in relation to carcase specifications.
Such comments show the toxic disregard at the heart of the farmer/processor relationship and indicates why the closed fist of penalties or pence per litre cuts are often used as a major communication tool by processors.
If we had a system which, instead of punishing farmers from the outset, sought to add bonuses on top of the base price the better the product they provided, surely the whole scenario would be more beneficial.
Fostering a us and them mentality within the industry itself is only going to be negative in the long run and, therefore, the issue of distrust will continue to linger.
Some politicians have said the separation from the EU could take as long as 10 years. Let us just hope our lobbying organisations have effective political teams in place whatever the timeframe.

domain: politics


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ergoPouch - 0.2 tog Cocoon Pouch Tales Quill Swaddle & Sleeping Bag
The ergoCocoon 'no origami' baby swaddle sleep bags are designed to be both easy to use and difficult to escape from.
The simple zip up design will keep baby snug and securely swaddled without the need for complicated wrapping.
The 0.2 TOG ergoCocoon swaddle sleep bag is designed for Summer temperatures, and made from a thin layer of stretchy cotton fabric.
FABRIC: 95% Organic Cotton/ 5% Elastane
- 0-3 Months - fits up to 7kgs - Length of swaddle - 58cm
- 3-12 Months - fits 7-12kgs - Length of swaddle -78cm


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Familial aggregation and excess maternal transmission of type 2 diabetes in Tunisia
- Imen Arfa1,
- Abdelmajid Abid2,
- Dhafer Malouche3,
- Nissaf Ben Alaya4,
- Théophile Roland Azegue1,*,
- Imen Mannai1,*,
- Mohamed Majdi Zorgati1,
- Mohamed Chiheb Ben Rayana2,
- Slim Ben Ammar1,
- Samira Blousa-Chabchoub2,
- Habiba Ben Romdhane5,
- Béchir Zouari6,
- Mohamed Koussay Dellagi7,
- Sonia Abdelhak1
- 1Molecular Investigation of Genetic Orphan Diseases Research Unit, Institut Pasteur de Tunis. Tunis, Tunisia
- 2National Institute of Nutrition, Tunis, Tunisia
- 3Engineering School of Statistics and Information Analysis (LEGI-EPT-ESSAIT), University of 7th November at Carthage Tunis, Tunisia
- 4Laboratory of Epidemiology. Institut Pasteur de Tunis, Tunis, Tunisia
- 5Cardiovascular Diseases Research Laboratory, School University of Medicine, University Tunis El Manar III, Tunis, Tunisia
- 6Department of Epidemiology and Statistics, School University of Medicine, University Tunis El Manar III, Tunis, Tunisia
- 7Laboratory of Immunopathology, Vaccinology and Molecular Genetics (LIVGM), Institut Pasteur, Tunis, Tunisia
- Correspondence to: Professor Sonia Abdelhak Institut Pasteur de Tunis, BP 74, 13 Place Pasteur 1002 Tunis Belvédère, Tunisie;
- Received 22 September 2006
- Accepted 23 January 2007
Aim: To evaluate the degree of familial aggregation of type 2 diabetes mellitus in Tunisia and to investigate transmission patterns of the disease and their relationships with patients’ clinical profiles.
Methods: Family history of diabetes and clinical data were collected for 132 unrelated type 2 diabetic Tunisian patients. Diabetes status was recorded for first degree relatives (parents, siblings) and second degree relatives (aunts and uncles from both maternal and paternal sides). Information about family history of diabetes was gathered for a total of 1767 individuals.
Results: Familial aggregation of type 2 diabetes was prominent and more important among first degree relatives than among second degree relatives (p = 0.01). Among studied subjects, 70% reported at least one relative with diabetes and 34% had at least one parent with diabetes. Diabetes was more frequent among mothers than fathers of probands (p = 0.03). This maternal effect extends to second degree relatives as diabetes was more common among maternal than paternal aunts and uncles (p = 0.01). There is no significant difference in clinical and metabolic profiles between patients according to transmission patterns of the disease.
Conclusion: These results suggest familial aggregation and excess maternal transmission of type 2 diabetes in the Tunisian studied population.
↵* Also Engineering School of Statistics and Information Analysis (LEGI-EPT-ESSAIT), University of 7th November at Carthage Tunis, Tunisia
Funding: This work was supported by the Tunisian Ministry for Scientific and Technological Research and Development of Competencies.
Competing interests: none

domain: biology


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The United States is in the midst of a growing public health problem — rates of several common sexually transmitted diseases have risen for four consecutive years. According to the federal Centers for Disease Control and Prevention, the U.S. as a whole has seen rates of chlamydia, gonorrhea, and primary and secondary syphilis rise four years in a row.
But what’s the STD situation here in Washington, D.C.? Which sexually transmitted diseases are the most common here, how have their rates changed over time, how does the District stack up against the states? To answer all those questions, we’ll dig into STD data from the CDC as well as the District of Columbia Department of Health HIV/AIDS, Hepatitis, STD, and TB Administration.
It’s important to note that in most STD publications, the CDC does not compare the District to states, and that’s because D.C. has by far the highest population density when compared to any other state, even ones that are very heavily populated.
Chlamydia Rates in D.C.
Among the 50 states, Alaska has the highest rate of chlamydia infections after adjusting for population differences. But if the District were included, it would have a rate that’s nearly double that of Alaska. D.C.’s rate is nearly three times the overall U.S. rate, which does include cases reported in the District.
Chlamydia infections per 100,000 people
|District of Columbia||1,463.6|
Chlamydia has become more common in the District over the past half-decade, with the infection rate in D.C. rising by more than one-third between 2013 and 2017.
District of Columbia chlamydia rate by year (cases per 100,000 people)
Six of the 10 states with the highest chlamydia rates are in the South, but the South also is home to the state with the lowest rate, West Virginia.
Chlamydia infection rate, Southern states (cases per 100,000 people)
|District of Columbia||1,463|
Gonorrhea Rates in D.C.
Mississippi leads the states in the prevalence of gonorrhea with a rate of 310 per 100,000 people, nearly 10 times higher than that of Vermont, with the lowest rate among the states. Including D.C. in the ranking pushes Mississippi down to No. 2, as the District’s rate is more than double Mississippi’s.
Gonorrhea infections per 100,000 people
|District of Columbia||730|
In three of the past five years, D.C. has recorded an increase in the gonorrhea rate, and between 2013 and 2017, the rate climbed by more than 70%.
District of Columbia gonorrhea rate by year (cases per 100,000 people)
Eight of the 10 states with the highest gonorrhea rates are in the South, and D.C.’s gonorrhea rate is more than 10 times higher than that of West Virginia, which has the region’s lowest rate.
Gonorrhea infection rate, Southern states (cases per 100,000 people)
|District of Columbia||730|
Syphilis Rates in D.C.
The overall infection rate in the U.S. for primary and secondary syphilis cases is 9.5 per 100,000, which is about half that of Nevada, which has the highest rate among the states. The District’s rate is nearly 5 times higher than the overall national rate and is just over double that of Nevada.
Primary and secondary syphilis infections per 100,000 people
|District of Columbia||45|
After a few years of decline, the syphilis rate has grown rapidly in D.C. over the past couple of years and it now stands at nearly 60% higher than it was in 2013.
District of Columbia primary and secondary syphilis rate by year (cases per 100,000 people)
Six in 10 of the states with the highest rates of syphilis are in the South, and D.C.’s rate is about 13 times higher than that of West Virginia, which has the region’s lowest rate.
Primary and secondary syphilis infection rates, Southern states (cases per 100,000 people)
|District of Columbia||45|
HIV & Other STD Rates in D.C.
More than 300 people were newly diagnosed with HIV in D.C. in 2017, and the District’s population adjusted HIV rate of 46.3 per 100,000 is considerably higher than Georgia, which has the highest rate among the states at 24.9 per 100,000. Still, D.C. did record a nearly 8% decline in the rate of new HIV infections. See How to Test for HIV
Hepatitis B & C
Acute infections of viral hepatitis, both hep B and hep C, have not been reported for the District for several years, but both infections occur nationally at a rate of about 1 per 100,000. See How to Test for Hepatitis
Human papillomavirus (HPV), in addition to being the single most common STD in the world, is also the chief cause of several types of cancer, including cervical, anal and penile cancers. So common is this infection that pinpointing exact numbers and rates for it is virtually impossible. That’s why examining the rate of HPV-related cancers can help provide a window into how commonly HPV goes untreated. In the District of Columbia, these cancers occur at a rate of about 13.9 per 100,000, higher than the national median of 11.7 per 100,000, but not the highest rate in the U.S. The highest rate is in Kentucky, where these cancers are diagnosed at a rate of 15.7 per 100,000. See How to Test for HPV
There’s no doubt that sexually transmitted diseases are a great and growing problem here in Washington, D.C, as in the rest of the country. But remember that while rates of chlamydia, gonorrhea and syphilis all have risen here, D.C. saw the rate of new HIV cases fall, which should signal to everyone that progress is possible. A key to helping bring down STD rates is for sexually active people to get tested so that they can be treated for any infections they may have but also so that they can break the cycle of STDs.
- District of Columbia Department of Health, HIV/AIDS, Hepatitis, STD, and TB Administration (HAHSTA), Annual Epidemiology & Surveillance Report. (2018). Retrieved from https://dchealth.dc.gov/sites/default/files/dc/sites/doh/publication/attachments/AR%20report%202018_v072518_FINAL.pdf
- Centers for Disease Control and Prevention, NCHHSTP AtlasPlus. (Undated). Retrieved from https://www.cdc.gov/nchhstp/atlas/index.htm
- Centers for Disease Control and Prevention, Sexually Transmitted Disease Surveillance 2017. (2018). Retrieved from https://www.cdc.gov/std/stats17/SRtables.pdf
- Centers for Disease Control and Prevention, HPV-Associated Cancer Rates by State, 2011-2015. (2018). Retrieved from https://www.cdc.gov/cancer/hpv/statistics/state/index.htm
- Centers for Disease Control and Prevention, HIV Surveillance Report, Diagnoses of HIV Infection in the United States and Dependent Areas, 2017. (2018). Retrieved from https://www.cdc.gov/hiv/pdf/library/reports/surveillance/cdc-hiv-surveillance-report-2017-vol-29.pdf
Note: Some states have published more recent data for chlamydia, gonorrhea, and primary and secondary syphilis. For states in which that’s the case, we have substituted the individual state data for 2018 and used that in our rankings, while other states’ rankings are based on 2017 numbers. In some cases, we assume that when the full national dataset is published by the CDC, states’ positions relative to other states will change some, though those changes are unlikely to be dramatic, since the CDC data comes from the states.


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In the physio clinic we are frequently asked about how to manage the first few days of a soft tissue injury, such as an ankle sprain or strain. Most commonly people are asking should they use ice or heat and whether to rest or move? Keep reading if you'd like to understand why ice is no longer recommended.
Here is a clear guide, taken from evidence based guidelines produced by the British Journal of Sports Medicine, so you can be sure you're looking after yourself or correctly advising others how best to recover after an acute soft tissue injury.
What is a soft tissue injury?
Soft tissues include ligaments, muscles and tendons. These soft areas of the body can become injured after a trauma like a strain, sprain or overload.
After an injury your body works hard to repair, recover and renew the affected area. The process starts with inflammation which often causes:
pain in and around the area
There are a few things you can do to help this process and get back to your usual activities.
Protect and Elevate
Generally, the first few days are the worst with regards to pain and limitation of movement. You should listen to your body and adapt your lifestyle to suit. Prop your arm up to help a sore shoulder or elevate a sprained ankle higher than the heart, as often as possible.
Avoid anti-inflammatory medication
Evidence suggests medications like Ibuprofen have limited benefits and may in some cases slow down tissue healing if taken too early in your recovery. Stick to paracetamol if you need pain relief or speak to your doctor or pharmacist for further advice.
Using a tubigrip style bandage or sports compression sleeve can be a helpful way to manage significant swelling. Make sure the fit is right, enough compression to support but not too tight. You can combine compression with elevation of the injured limb.
Recent studies have now identified that the use of ice for acute soft tissue injuries is NO LONGER RECOMMENDED. It is safe to use for pain management but it can delay the start of the healing process.
The problem with using ice is that it is a vasoconstrictor, thus it limits blood supply and therefore swelling, but in turn that also limits the arrival of immune cells and thus interferes with that start of the healing process.
Do not use heat in the first few days of a soft tissue injury. If you do choose to use ice, never place it directly on your skin and use a barrier, like a damp tea towel, to protect your skin from a burn. Use the ice for around 15 minutes and apply every few hours.
*If you are diabetic or have diabetic neuropathy, or other issues with circulation or sensation you should not use ice.
Remember too much rest can slow down your recovery, as soon as you can start moving and using the affected area. You could use a walking aid to help you get around, if you've strained your calf muscle or ankle. Continue to stay within acceptable pain limits but remember you don’t need to be pain free. Aim to do a little bit more each day or every few days.
If the site of your injury becomes very painful, swelling worsens or the area becomes very red and hot, seek advice from a healthcare professional.
Repair, Restore and Renew
As your symptoms settle, the pain eases and your confidence to use the affected area grows, start to re-introduce normal activties, movement, strength exercises and functional activities.
All these actitvies and movements help reduce stiffness, pain and swelling. They also, most importantly, provide your body with the vital information and stimulation it needs to repair, restore and renew itself.
Most people can recover from a soft tissue injury by following the guidelines above. However if you sustained a nasty ankle sprain or perhaps your shoulder pain, after too much gardening, isn't settling and repairing, then do book in to see one of our physiotherapists. You might just need a bit of extra help to get back to normal, and we can provide that! Book in online here or call the clinic on 01932 645320 to book an appointment.


When it comes to air conditioner suggestions, there are numerous to choose from. We’ve already talked about the consolation aspect of having an air conditioner, but there are another recommendations for many who may be somewhat uncomfortable with their conditioner but want it in the heat of summer season.
Do not use myair ducted air conditioner brisbane https://www.smarterair.com.au/ducted-air-conditioning-installation/ for adjusting the room temperature. While it is good to have the ability to lower or increase the temperature along with your fingers, the settings are too delicate for this, so keep in mind that a fidgety teen won’t have the ability to dial in the proper temperature simply.
Earlier than attempting to adjust the temperature, unplug the air conditioner to take the stress off the thermostat. Once the air conditioner is plugged in, set the thermostat to the identical temperature because the room. You will want to search out the energy ranking of the unit after which multiply it by 100.
One way to change the temperature shortly is to use your hair dryer fan to move air by means of the air conditioner. more information helps the cool air filter to move faster through the system, which helps to maintain the temperature at a normal level for the room.
Eliminate unsightly items on the window sill or next to the air conditioner. This may be clutter from years of put on and tear, nevertheless it can cause the air conditioner to get too scorching, so eliminate it! And whereas Air Conditioner Tips To Keep Up Your System are at it, try to maintain your windows open for maximum air circulate by way of the unit.
Air Conditioner Suggestions That Might Help You Retain Your Room Cool is at all times better than cure, and it is simply as true for air conditioning as it is for the rest in your house. Be certain to frequently clear out the filters to keep them from clogging. You additionally need to make sure to alter the oil, and never just the filter.
Keep the home windows cleaned out, too. If you do not have home windows in your home, you could must cowl them to allow satisfactory air movement. Both approach, windows are not only needed in the summer time, but throughout the year.
One of the best air conditioner suggestions is to do your homework on the air conditioning units that you are interested by buying. Take http://realitysandwich.com/?s=air+conditioning+tips to go to totally different areas and ask questions, and you could also be surprised to search out that there are some options that you simply did not know you needed.
Some people desire them during household vacations away from dwelling. Others could choose them for maintaining the toes cool while staying indoors when it’s cool outdoors.
Reference employed: http://realitysandwich.com/?s=air+conditioning+tips
For people who’re a bit extra cell, a superb suggestion is to have one of the items mounted on the back of a automotive. The massive fan blows air into the room, and keeps the room cool with out the need for followers or air conditioning models in different rooms.
Air Conditioner Ideas For Summertime include retaining the unit clean and freed from dust, debris, and pet hair. This stuff may cause injury to the unit and keep it from working as effectively as it should.
Finally, with regards to holding your unit clear, it is as simple as protecting the realm clean around it. myair ducted air conditioner brisbane don’t have to vacuum it every single day, but if you discover an area that doesn’t seem to have an issue with mud, remove it and clean it with a vacuum cleaner.


Botrytis blight on bigleaf hydrangea (Hydrangea macrophylla) blooms
Botrytis blight on Chinese dogwood (Cornus kousa)
These leaf spots on New Guinea impatiens (Impatiens hawkeri 'Sunpatiens') may look colorful, but they are probably caused by Botrytis blight, a fungal disease
Botrytis blight on rose (Rosa) blossom
Fungal spores of botrytis blight on New Guinea impatiens flower (Impatiens hawkeri group)
Botrytis blight, also know as gray mold, is a fungal disease caused by several species in the genus Botrytis. It affects the buds, flowers, leaves, and bulbs of many plants including African violet, begonia, chrysanthemum, cyclamen, dahlia, geranium, lily, peony, rose, and tulip. The extent and severity depend on weather conditions and cultural practices. This disease is the primary cause of decay in cut flowers.
Symptoms and Diagnosis
Botrytis blight causes buds and flowers to develop abnormally and turn brown. Flowers may have irregular flecks and brown spots; older flowers tend to rot quickly. Soft, brown spots appear on leaves, stems, and flowers following a cool damp period. Affected parts may be covered with a gray mold following damp, cool weather.
Botrytis fungi overwinter as sclerotia on dead plant debris in the garden. In the spring, spores form and spread by wind or splashing water to infect dying, wounded, or extremely soft plant tissues. Fungal mycelial strands (web blight) from previously infected plant parts can grow onto healthy plant parts and infect them. The fungus is capable of invading tissue during all periods of the growing season and multiplies rapidly in declining foliage, hence, the need for good sanitation.
Integrated Pest Management Strategies
1. Practice good sanitation. Remove and destroy all infected plant parts as soon as they are observed.
2. Avoid overcrowding. Give adequate space between plants to allow for good air circulation. The fungus thrives in areas that are cool and moist and where plants are overcrowded.
3. Do not overfeed. Avoid fertilizing with excessive amounts of nitrogen. This can cause tender growth that is very susceptible to the fungus. Get a soil test to guide fertilizer practices.
4. Avoid overhead watering. Water on foliage and flowers from overhead irrigation, especially on cool, cloudy days, promotes the disease. Try to keep buds and flowers dry. Water early in the day so the plants have enough time to dry off completely.
5. Use fungicides. Depending upon the susceptibility of the plant to this disease, spray every 10 days with a fungicide. Pesticides registered for use include copper, captan, chlorothalonil (Daconil), mancozeb, maneb, sulfur, and thiophanate methyl (Cleary 3336). Fungicides must be applied in advance of the disease as a protectant.
Strategies 1, 2, 3, and 4 (if organic fertilizers are used) are organic approaches. Of the fungicides listed in Strategy 5, consult the Organic Materials Review Institute (OMRI™) for appropriate organic copper or sulfur products.


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A law institutionalizing gay marriage would merely reinforce a healthy social trend just married same sex marriage wedding since there's no reason gays should not be allowed to adopt or be foster parents, it could also. Free essay: on june 26, 2015, the us supreme court ruled that the us constitution guarantees the right for same-sex couples to marry should gay marriages. Same-sex couples now have the equal right to marry, the rights and responsibilities attached to the status' of opposite-sex marriage and same-sex marriage must be this would set out the framework for adultery, but would allow a natural.

domain: law


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text:
I cannot be happy like this,
I literally cannot live like this,
Why? And for what?
My days are full of numbers,
Labels and counting,
It’s a day of measuring, timing,
Frustration, doubt, and anxiety.
Its a day of covering up my collarbones
That are sticking out too much,
Or my legs and arms,
That have stretch so thin.
Its a day of conflicting thoughts,
Of whether I should have less or more,
Wondering if my family would notice,
Something missing on my plate.
Its a day of always moving,
Playing with my hands, bouncing my leg,
Stretching my weakening and sore muscles.
Its a day of avoiding people,
Wondering if they see of miserable I have become,
How tired I now feel,
Do they see a ghost of the girl I was?
Why? And for what? I ask myself.
The answer is not nothing,
The answer is Miss. Ana,
Because I may be a ghost,
But I still can be haunted.


text:
Grays Harbor Tourism grant applications are now being accepted from qualifying entities organizing tourism based activities, tourism promotion, and hospitality projects that are aimed at increasing and/or supporting the tourism industry within Grays Harbor County.
Grant funding is provided to increase and support tourism activity within the county.
The grant categories and their deadlines are as follows:
- Festival and Event Grants (deadline Oct. 27, 2023)
- Tourism Hospitality and Special Projects Grants (deadline Oct. 27, 2023)
- Major Tourism Projects (deadline Oct. 27, 2023)
- Destination Marketing Partnership Grants (deadline Oct. 27, 2023)
Under State law (RCW 67.28) Grays Harbor County receives funds from lodging taxes imposed on commercial overnight stays. These funds can be retained and utilized by the County for tourism marketing, the operation and development of tourism generating facilities, qualifying tourism hospitality projects, or expended for events & activities deemed to generate visitors from a distance of fifty miles, or greater.
Full details regarding qualifying entities and expenses are available on the appropriate grant application.
Additional, helpful information is available on the County Tourism Department website at https://visitgraysharbor.com/programs/.
Applicants with additional questions can also contact the Grays Harbor Tourism Office, which allocates over $400,000 in grant funds, annually.
“We are very fortunate that our County Commissioners have continued to support the funding of this grant program. They understand that tourism is vital to Grays Harbor’s economic success and they’ve supported investing in the long term sustainability of our tourism industry,” said Mike Bruner, Grays Harbor County Tourism Director.
Applications for grant funding are available from the Grays Harbor Tourism office or can be downloaded from the Grays Harbor Tourism website at visitgraysharbor.com.
For more information, contact Emma Raub, Grays Harbor Tourism Office Manager and Public Relations Coordinator, at 360-482-2651, ext. 1876, or by email at [email protected].

domain: economics