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Nanomolar affinity cannabinoid receptor agonist (K
values are 62.3 and 3.3 nM at the human cloned CB
S-enantiomer also available.
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Feeding induced by cannabinoids is mediated independently of the melanocortin system.
Authors: Sinnayah Et al.
Cannabinoids reduce markers of inflammation and fibrosis in pancreatic stellate cells.
Authors: Michalski Et al.
Am J Physiol Gastrointest Liver Physiol ;3:e1701
The synthetic cannabinoid WIN-55,212-55,212 induced-apoptosis in cytotrophoblasts cells by a mechanism dependent on CB1 receptor.
Involvement of cannabinoid system in the nucleus accumbens on delay-based decision making in the rat.
Behav Brain Res. 2017;337:107
Characterization of structurally novel G protein biased CB1 agonists: implications for drug development.
Pharmacol Res 2017;125:161
Decreased CB receptor binding and cannabinoid signaling in three brain regions of a rat model of schizophrenia
Authors: Szücs Et al.
Neuroscience Letters 2016;633:87
WIN 55,212-2 inhibits the epithelial mesenchymal transition of gastric cancer cells via COX-2 signals
Authors: Xian Et al.
Cell Physiology and Biochemistry 2016;39:2149
Somatostatin receptor 5 is a prominent regulator of signaling pathways in cells with coexpression of Cannabinoid receptors 1
Authors: Zou Et al.
Correlations between the Memory-Related Behavior and the Level of Oxidative Stress Biomarkers in the Mice Brain, Provoked by an Acute Administration of CB Receptor Ligands.
Authors: Kruk-Slomka Et al.
Neural Plast 2016;2016:9815092
Cannabinoid WIN-55,212-2 mesylate inhibits ADAMTS-4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan-1.
Authors: Kong Et al.
Int J Neuropsychopharmacol 2016;13:4569
(4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)(cyclohexyl)methanone hydrochloride (LDK1229): a new cannabinoid CB1 receptor inverse agonist from the class of benzhydryl piperazine analogs.
Authors: Mahmoud Et al.
Mol Pharmacol 2015;87:197
TRPA1 mediates the hypothermic action of acetaminophen.
Authors: Gentry Et al.
Br J Pharmacol 2015;5:12771
Behavioral and neurochemical changes in mesostriatal dopaminergic regions of the rat after chronic administration of the cannabinoid receptor agonist WIN55,212-2.
Authors: Fanarioti Et al.
Int J Mol Sci 2015;18
Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
Authors: Lin Et al.
Sci Rep 2015;16:5555
The cannabinoid agonist HU-210: pseudo-irreversible discriminative stimulus effects in rhesus monkeys.
Authors: Hruba and McMahon
Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1.
Authors: Flores-Otero Et al.
Nat Commun 2014;5:4589
Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain.
Authors: Levin Et al.
Eur J Pharmacol 2014;5:10
Miswiring the brain: △9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway.
Authors: Tortoriello Et al.
Br J Pharmacol 2014;33:668
The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
Authors: Sánchez-Blázquez Et al.
Mol Med Rep 2014;17:1943
Inhibition of p38/Mk2 signaling pathway improves the anti-inflammatory effect of WIN55 on mouse experimental colitis.
Authors: Li Et al.
Lab Invest 2013;93:322
CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.
Authors: Baillie Et al.
Mol Pharmacol 2013;83:322
Fluoxetine impairs GABAergic signaling in hippocampal slices from neonatal rats.
Authors: Caiati and Cherubini
Front Cell Neurosci 2013;7:63
CB1 and CB2 receptors are novel molecular targets for Tamoxifen and 4OH-Tamoxifen.
Authors: Prather Et al.
Biochem Biophys Res Commun 2013;441:339
Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory.
Authors: Abush and Akirav
Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2.
Authors: Marcu Et al.
J Pharmacol Exp Ther 2013;345:189
The non-selective cannabinoid receptor agonist WIN 55,212-2 attenuates responses of C-fiber nociceptors in a murine model of cancer pain.
Authors: Uhelski Et al.
Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action.
Authors: Cawston Et al.
Br J Pharmacol 2013;170:893
Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors.
Authors: Marini Et al.
Br J Pharmacol 2013;169:887
The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells.
Authors: Sreevalsan and Safe
Mol Cancer Ther 2013;12:2483
Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity.
Authors: Brents Et al.
Biochem Pharmacol 2012;83:952
CB1 receptor autoradiographic characterization of the individual differences in approach and avoidance motivation.
Authors: Laricchiuta Et al.
PLoS One 2012;7:e42111
Short- and long-term cognitive effects of chronic cannabinoids administration in late-adolescence rats.
Authors: Abush and Akirav
PLoS One 2012;7:e31731
Stress hormones receptors in the amygdala mediate the effects of stress on the consolidation, but not the retrieval, of a non aversive spatial task.
Authors: Segev Et al.
PLoS One 2012;7:e29988
A Role for the Cannabinoid 1 Receptor in Neuronal Differentiation of Adult Spinal Cord Progenitors in vitro is Revealed through Pharmacological Inhibition and Genetic Deletion.
Authors: Sideris Et al.
Front Neurosci 2012;6:4
Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference.
Authors: Zhong Et al.
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Authors: Caiati Et al.
Sci Rep 2012;2:285
The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55.
Authors: Kargl Et al.
J Biol Chem 2012;287:44234
TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception.
Authors: Giordano Et al.
Cereb Cortex 2012;22:2495
Effect of cannabinoid receptor activation on spreading depression.
Authors: Kazemi Et al.
Iran J Basic Med Sci 2012;15:926
Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.
Authors: Liu Et al.
Mol Cancer Ther 2012;11:1421
Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity.
Authors: Brents Et al.
PLoS One 2011;6:e21917
High extracellular Ca2+ stimulates Ca2+-activated Cl- currents in frog parathyroid cells through the mediation of arachidonic acid cascade.
Authors: Okada Et al.
PLoS One 2011;6:e19158
Cannabinoids attenuate hippocampal γ oscillations by suppressing excitatory synaptic input onto CA3 pyramidal neurons and fast spiking basket cells.
Authors: Holderith Et al.
J Neurosci 2011;589:4921
Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis.
Authors: Preet Et al.
Cancer Prev Res (Phila) 2011;4:65
Effects of drugs of abuse on putative rostromedial tegmental neurons, inhibitory afferents to midbrain dopamine cells.
Authors: Lecca Et al.
Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of δ9-tetrahydrocannabinol on spatial memory.
Authors: Sousa Et al.
Cannabinoid transmission in the basolateral amygdala modulates fear memory formation via functional inputs to the prelimbic cortex.
Authors: Tan Et al.
J Neurosci 2011;31:5300
The distinct role of medium spiny neurons and cholinergic interneurons in the D2/A2A receptor interaction in the striatum: implications for Parkinson's disease.
Authors: Tozzi Et al.
J Neurosci 2011;31:1850
Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice.
Authors: Pan Et al.
J Cell Biol 2011;31:13420
The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment.
Authors: Schicho Et al.
Inflamm Bowel Dis 2011;17:1651
Endocannabinoids mediate synaptic plasticity at glutamatergic synapses on spiny neurons within a basal ganglia nucleus necessary for song learning.
Authors: Thompson and Perkel
J Neurophysiol 2011;105:1159
The cannabinoid WIN55,212-2 protects against oxidized LDL-induced inflammatory response in murine macrophages.
Authors: Hao Et al.
J Neurosci 2010;51:2181
Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo.
Authors: Jones Et al.
Br J Pharmacol 2010;332:569
Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy.
Authors: Wyeth Et al.
J Neurosci 2010;30:8993
Cannabinoids excite circadian clock neurons.
Authors: Acuna-Goycolea Et al.
PLoS One 2010;30:10061
Retrograde endocannabinoid signaling reduces GABAergic synaptic transmission to gonadotropin-releasing hormone neurons.
Authors: Farkas Et al.
J Biomol Screen 2010;151:5818
Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.
Authors: Kim and Alger
Nat Neurosci 2010;13:592
Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine.
Authors: Garzón Et al.
Mol Pain 2009;5:11
Cannabinoid regulation of nitric oxide synthase I (nNOS) in neuronal cells.
Authors: Carney Et al.
J Neuroimmune Pharmacol 2009;4:338
WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
Authors: Price Et al.
Eur J Neurosci 2009;29:2177
Effects of cannabinoids on caffeine contractures in slow and fast skeletal muscle fibers of the frog.
Authors: Huerta Et al.
J Membr Biol 2009;229:91
Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats.
Authors: Ho and Gardiner
Front Pharmacol 2009;156:94
Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter β-arrestin assay.
Authors: McGuinness Et al.
Int J Neuropsychopharmacol 2009;14:49
TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
Authors: Gibson Et al.
Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus.
Authors: Chiu and Castillo
Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others.
Authors: Karson Et al.
J Physiol 2008;54:117
Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction.
Authors: Kapur Et al.
J Pharmacol Exp Ther 2008;325:341
The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms.
Authors: Potenzieri Et al.
Brain Res 2008;1215:69
Potentiation of electrical and chemical synaptic transmission mediated by endocannabinoids.
Authors: Cachope Et al.
N-arachidonoyl-dopamine tunes synaptic transmission onto dopaminergic neurons by activating both cannabinoid and vanilloid receptors.
Authors: Marinelli Et al.
Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous γ-aminobutyric acid release onto cerebellum Purkinje neurons.
Authors: Kelm Et al.
J Neurosci 2007;323:356
Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum.
Authors: Narushima Et al.
J Neurosci 2007;27:496
Cannabinoids excite hypothalamic melanin-concentrating hormone but inhibit hypocretin/orexin neurons: implications for cannabinoid actions on food intake and cognitive arousal.
Authors: Huang Et al.
J Neurosci 2007;27:4870
The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo.
Authors: Pertwee Et al.
Br J Pharmacol 2007;150:586
Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation.
Authors: Hoffman Et al.
Learn Mem 2007;14:63
Species and strain differences in the expression of a novel glutamate-modulating cannabinoid receptor in the rodent hippocampus.
Authors: Hoffman Et al.
J Lipid Res 2005;22:2387
Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist.
Authors: Thomas Et al.
Br J Pharmacol 2005;146:917
Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves.
Authors: MacNaughton Et al.
Eur J Neurosci 2004;286:G863
Electrical coupling among irregular-spiking GABAergic interneurons expressing cannabinoid receptors.
Authors: Galarreta Et al.
J Pharmacol Exp Ther 2004;24:9770
Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons.
Authors: Melis Et al.
J Neurosci 2004;24:10707
Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain.
Authors: Costa Et al.
J Neurosci 2004;141:42586
The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response.
Authors: Williams Et al.
EMBO J 2003;160:481
Direct inhibition by cannabinoids of human 5-HT3A receptors: probable involvement of an allosteric modulatory site.
Authors: Barann Et al.
Br J Pharmacol 2002;137:589
Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease.
Authors: McKallip Et al.
A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.
Authors: Craib Et al.
PLoS One 2001;134:42581
The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain.
Authors: Bridges Et al.
Br J Pharmacol 2001;133:586
Modulation of peristalsis by cannabinoid CB(1) ligands in the isolated guinea-pig ileum.
Authors: Izzo Et al.
Br J Pharmacol 2000;129:984
Central and peripheral cannabinoid modulation of gastrointestinal transit in physiological states or during the diarrhoea induced by croton oil.
Authors: Izzo Et al.
Br J Pharmacol 2000;129:1627
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text:
Mons is a great city for kids of all ages. Here are some of the top kid-friendly things to do in Mons:
1. Visit the Belfry of Mons. This imposing 13th-century belfry is one of the most iconic landmarks in the city. Kids will love climbing the 366 steps to the top for amazing views of Mons and the surrounding region.
2. Explore the Grand-Place. This beautiful square is the perfect place to people watch and appreciate the stunning architecture of the surrounding buildings. Kids will also enjoy seeing the statue of Saint Waudru, the city’s patron saint.
3. Visit the BAMM! Music Museum. This fun museum is dedicated to music and musical instruments. Kids will love exploring the interactive exhibits and playing the instruments in the “play room”.
4. Take a walk in the Parc de la Boverie. This large park is perfect for a leisurely stroll or a picnic lunch. Kids will enjoy seeing the ducks and geese in the park’s pond and exploring the maze.
5. Ride the Mons Tram. This vintage tram runs through the city center and is a great way to see the sights. Kids will love riding in the old-fashioned tram cars.
10 Fun & Kid-Friendly Things To Do In Mons, Belgium
1. Climb the Belfry of Mons
The Belfry of Mons is a UNESCO World Heritage Site and one of the most iconic landmarks in the city. The Belfry dates back to the 13th century and isopen to the public for tours. Visitors can climb the 363 steps to the top of the tower for panoramic views of Mons and the surrounding area.
2. Visit the Grand-Hornu
The Grand-Hornu is a UNESCO World Heritage Site and one of the most important industrial archaeological sites in Europe. The site includes several former coal mines, a workers’ village, and a boiler house. Visitors can explore the site on a guided tour or on their own.
3. Tour the Mons Memorial Museum
The Mons Memorial Museum is dedicated to World War I and the Battle of Mons. The museum is located in the former town hall, which was damaged during the war. The museum features exhibits on the battle, the soldiers who fought in it, and the civilian population who suffered during the war.
4. See the Tournai Cathedral
The Tournai Cathedral is a UNESCO World Heritage Site and one of the most beautiful Gothic churches in Europe. The cathedral is open to the public for tours and visitors can climb to the top of the tower for views of the city.
5. Visit the Lamon House
The Lamon House is a historic house museum which was once the home of Jules Destrebecq, a famous Belgian painter. The house has been turned into a museum with exhibits on Destrebecq’s life and work.
6. Stroll through the Jardin du Mont Saint-Pierre
The Jardin du Mont Saint-Pierre is a public park located on the site of a former quarry. The park offers scenic views of the city and the valley below. Visitors can also see the ruins of a 12th century castle.
7. Take a ride on the Mons Cable Car
The Mons Cable Car is a fun way to see the city from above. The cable car takes visitors from the city center to the top of the hill near the Grand-Hornu.
8. Visit the BAMM Arts Center
The BAMM Arts Center is a museum and arts center dedicated to contemporary art. The center features a range of exhibits, workshops, and events.
9. See the Mosan Tapestry
The Mosan Tapestry is a UNESCO World Heritage Site and one of the largest tapestries in the world. The tapestry is located in the town of Grimbergen and measures 36 meters long by 14 meters wide.
10. Go for a walk in the Mons Woods
The Mons Woods are a protected area of forest located just outside the city. The woods are a great place for a walk or hike and offer views of the city and the countryside.

domain: travel


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text:
tiruchy l thursday l October 08, 2020 l `7.00 l PAGES 12 l late city edition chemistry Nobel prize goes to two women scientists Frenchwoman Emmanuelle Charpentier and Jennifer Doudna of the US jointly won the prize for their work on gene editing Jennifer Doudna Emmanuelle Charpentier Tool to change DNA with high precision Potential to cure genetic disorders Working on opposite sides of the Atlantic, the two developed a method known as CRISPR/Cas9 that can be used to change the DNA of animals, plants and micro organisms with extremely high precision. The US-French duo’s technology has been transformative for basic science research and it could also be used to treat, or even cure, inherited illnesses | P12 ■ ■ ■ The genome editing tool has contributed to many discoveries; in medicine, clinical trials of new cancer therapies are underway It is also being tested for its potential to treat sickle cell anaemia However, critics say that without regulation, Crispr could be used to create “designer babies”, opening up an ethical minefield FIRST This is the 1st Time chemistry nobel has gone to a women-only team CHENNAI ■ MADURAI ■ VIJAYAWADA ■ BENGALURU ■ KOCHI ■ HYDERABAD ■ VISAKHAPATNAM ■ COIMBATORE ■ KOZHIKODE ■ THIRUVANANTHAPURAM ■ BELAGAVI ■ BHUBANESWAR ■ SHIVAMOgGA ■ MANGALURU ■ TIRUPATI ■ TIRUCHY ■ TIRUNELVELI ■ SAMBALPUR ■ HUBBALLI ■ DHARMAPURI ■ KOTTAYAM ■ KANNUR ■ VILLUPURAM ■ KOLLAM ■ WARANGAL ■ TADEPALLIGUDEM ■ NAGAPATTINAM ■ THRISSUR ■ KALABURAGI Andhra govt firm on Amaravati land scam probe, appeal finally listed in SC E x p r e s s N e w s Se r v i c e @ New Delhi the Andhra Pradesh government is unlikely to budge an inch from its decision to probe alleged irregularities committed by the Chandrababu Naidu regime in the execution of the Amaravati greenfield capital city project despite legal hurdles in the high court, delays in the Supreme Court and stiff opposition from the TDP. It is learnt the government’s standing counsel in New Delhi has written to the SecretaryGeneral of the Supreme Court, drawing his attention to the delay in listing the special leave petition filed on September 22 against the high court stay on Government Orders pertaining to the constitution of a Cabinet Sub-Committee and a special investigation team to review decisions taken by the previous TDP regime and probe the alleged Amaravati land scam, respectively . In the missive, he explained all defects in the plea had been rectified but it was yet to be numbered despite repeated follow up. “The matter is of significant importance to the State as it relates to investigation into the conduct of highranking officials,” he said, requesting the Secretary General’s intervention. The SLP in question was filed consequent to the high court’s stay order issued on September 16 on a writ petition filed by TDP leader Varla Ramaiah. The high court order had dismayed the government for it had ruled that “If previous government’s decisions were to be reviewed, the present dispensation ought to have legislative approval. A government on its own cannot do so and no law has conferred such powers on the State government.” The state government filed another SLP in the apex court on September 21 against another high court order that gagged the media from reporting on an FIR filed by the AntiCorruption Bureau against Dammalapati Srinivas, former Advocate General, and 12 others including the family members of a Supreme Court judge, in the Amaravati land scam. The high court had also stayed further probe in the matter. Sasikala’s `2,000-crore worth assets attached Occupying public ways for protest illegal, rules SC on Shaheen Bagh E XPR E SS N E WS S E RVIC E The Supreme Court on Wednesday ruled that public places cannot be occupied indefinitely for protests, which must be carried out in designated areas alone. A bench headed by Justice S K Kaul said, “Democracy and dissent go hand in hand, but then the demonstrations expressing dissent have to be in designated places alone. The present case was not even one of protests taking place in an undesignated area, but was a blockage of a public way which caused grave inconvenience to commuters.” The order was passed on batch of petitions against the E x p r e s s N e w s Se r v i c e @ New Delhi @ Chennai THE Income Tax Department has attached assets worth `2,000 crore belonging to VK Sasikala, her sister-in-law Ilavarasi and nephew VN Sudhakaran in Kodanad, Nilgiris and Siruvathur near Chennai. The assets were attached by the Benami Prohibition Wing. All the three owners of these properties are currently serving a four-year sentence in a disproportionate assets case. Sasikala is alleged to have purchased these properties – including a plot near Veda Nilayam in Poes Garden, which was attached earlier – through shell companies. I-T sources said the attachment notice was served to Sasikala at the Parappana AgSasikala rahara Prison in Bengaluru. Notices were served to the benami firms and sub-registrar offices under whose jurisdictions these properties are located. Former CM Jayalalithaa’s niece Deepa and nephew Deepak have also been served notices. The provisional order of attachment has been issued under section 24(3) of the Prohibition of Benami Property Transactions Act, 1988. The tax department had conducted massive raids against Sasikala and a few others in 2017 and it is understood that the documents about these assets were recovered then. TN’S COVID BATTLE 5,447 fresh cases 67 6,35,855 Deaths tally Chennai reported 1,369 cases. Its neighbouring districts, Chengalpattu, Kancheepuram and Tiruvallur recorded 324, 138, and 252 cases respectively. Among other districts, Coimbatore reported 473 cases, Salem 322, Erode 149 and Tirupur 182 cases. Chief Minister Edappadi K Palaniswami presents Deputy CM O Panneerselvam with a shawl after being announced as AIADMK’s CM candidate for the upcoming Assembly polls, at the party headquarters in Chennai on Wednesday | P jawahar Palaniswami chosen CM candidate unanimously AIADMK steering committee becomes a reality three years after its announcement; powers of the panel yet to be worked out T MURUGA N A N D HAM @ Chennai ALLAYING speculation, the ruling AIADMK on Wednesday unanimously elected incumbent Chief Minister Edappadi K Palaniswami as its chief ministerial candidate for the upcoming Assembly elections. “It is with joy that I announce that Palaniswami has been unanimously elected as the victorious CM candidate of the party for 2021 elections,” announced O Panneerselvam amid cheers from the cadre. Thanking the party for announcing him as the CM candidate, Palaniswami tweeted that he would work tirelessly to make the AIADMK a victorious political movement. He also promised to lead the party, taking into consideration the views of the cadre. Meanwhile, the 11-member steering committee also became a reality, three years after it was announced. Palaniswami and Panneerselvam have their members in the ratio 6:5. The powers of the said committee have not been announced. Senior leaders said those details would be worked out during the general council meeting. The details so far were finalised after long parleys that began on Tuesd ay l a s t e d t i l l 3 a m o n Wednesday. Members of the steering committee are: ministers Dindigul C Sreenivasan, P Thangamani, SP My gratitude will not remain in just letters. With cooperation from the party cadre, I will ensure that this political revolution helps AIADMK retain power for a third time Edappadi K Palaniswami Happy development, says BJP Reacting to the matter, senior TN BJP leader, Pon Radhakrishnan, said, “It is a happy development. This has thwarted expectations of those (political adversaries) waiting to take advantage of the differences of opinion among AIADMK leaders. I congratulate Palaniswami on being elected as CM candidate and also greet Panneerselvam who took the decision.” Velumani, D Jayakumar, CVe Shanmugam, and R Kamaraj; organising secretaries JCD Prabhakar, PH Manoj Pandian and P Mohan; election committee joint secretary R Gopala Krishnan; and Sholavandan MLA K Manikam. While former Chief Minister J Jayalalithaa used to appoint women to all party fora, this committee has no women in it. After the announcements, Palaniswami and Panneerselvam accompanied by all ministers and functionaries paid respects at the memorials of former Chief Ministers MG Ramachandran and J Jayalalithaa. In the evening, Palaniswami called on Panneerselvam at the latter’s residence and thanked him for announcing his name as the party’s chief ministerial candidate. Most of the members of the steering committee, along with P Ravindranath, son of Panneerselvam, were also present during the meeting which lasted for around 45 minutes. Later, while thanking the party cadre, Palaniswami asked all of them to work unitedly to ensure a third-consecutive victory for the party in the upcoming Assembly elections. “My gratitude will not remain as just words. With the cooperation of the party, I will ensure that this political revolution helps AIADMK retain power for a third time,” Palaniswami said in a letter addressed to the cadre. EPS’ WAY UP: BRANCH SECY TO CM | P4 hc a s k s g o v t @ Chennai The Madras High Court on Wednesday wondered how college students could be declared “pass” without writing exams. The two-member bench comprising Justices M Sathyanarayana and R Hemalatha made the oral observations while hearing a plea filed by E Balagurusamy, former ViceChancellor of Anna University , who challenged the State government’s decision to cancel arrear exams for final year students. The court added that there would be consequences if students come filing pleas supporting the government’s decision in cancellation of arrears. In such a case, the bench said, the list of arrears in all semesters and marks scored in board exams will be sought from students. The All India Council for Technical Education (AICTE), in its submissions stated, an exemption from arrear exams as granted by the State is not as per the guidelines of the University Grants Commission (UGC). It said, “The council has not issued any exemption for students from appearing for the exams and pursuing their studies for the next year without being exemption not as per ugc guidelines: AICTE The All India Council for Technical Education (AICTE), in its submissions, stated that an exemption from appearing for arrear examinations as granted by the State government, is not as per the guidelines issued by the University Grants Commission (UGC) Former CBI director commits suicide Chandigarh: Retired CBI director and former governor of Nagaland Ashwani Kumar allegedly committed suicide by hanging on Wednesday. Police sources said he was under depression and took the extreme step at his residence at Brockhorst in Shimla. After 28 days in jail, Rhea granted bail Mumbai: The Bombay High Court on Wednesday granted bail to actor Rhea Chakraborty in a drugs case related to the death of her partner Sushant Singh Rajput, 28 days after she was in jail. The court, however, rejected the bail plea of her brother Showik Phase III trial plan for Sputnik V to be revised New Delhi: India’s drug regulator has rejected a proposal by Dr Reddy’s Labs for Phase III trial for Russian Covid-19 vaccine Sputnik V, in India saying the sample size for its early human trials were “small”. It has sought a fresh proposal for Phase II and III trials in India assessed. Degrees cannot be awarded to a student who has failed to clear a large number of arrears. This is not acceptable in the industry too.” The court also observed that it cannot take a different stand from that of an expert body like the AICTE. Prior to adjourning the plea, the bench added that it was saddening that several students who passed engineering courses were now working as food delivery agents. The court also ordered notice to the UGC to respond to the issue, and adjourned the case to November 20. Administration ticked off “In what manner the administration should act is their responsibility and they should not hide behind the court orders or seek support therefrom for carrying out their administrative functions,” the bench said @ New Delhi / Bengaluru With an eye on next month’s elections, US President Donald Trump on Wednesday announced tightening of non-immigrant visa rules to benefit American workers. The move is expected to impact thousands of IT professionals from India, which is one of the largest beneficiaries of H-1B visas. Already, a large number of Indians on H-1B visas have lost their jobs owing to the coronavirus pandemic that has severely hit the US economy . H-1B is a non-immigrant visa that allows US firms to employ foreign workers in speciality occupations that require clear that public ways and public spaces cannot be occupied in such a manner and that too indefinitely,” the bench ruled. “Administration ought to take action to keep the area clear of encroachments and obstructions,” the bench said, while calling their inability to resolve the protest as unfortunate. It noted the court was forced to intervene because there was no action by the administration. The bench also highlighted how social media can lead to a highly polarising environment, as in Shaheen Bagh. “We live in an age of technology and development and social media often sees parallel conversations with no constructive outcome,” it said. Call to ban or police fest sale by e-tailers E x p r e s s N e w s Se r v i c e @ New Delhi Deep discounting by ecommerce giants such as Amazon and Flipkart during ‘festival sales’ is “utter violation of India’s FDI policy”, the Confederation of All India Traders alleged in a letter to Finance Minister Nirmala Sitharaman. In its letter dated October 7, CAIT, which represents seven crore traders across the country, has sought a ban on the seasonal sales saying such predatory pricing also causes huge loss of GST revenue to the government. The letter, signed by CAIT national general secretary Praveen Khandelwal, said these companies are authorised to do only Business to Business (B2B) act iv i t i e s b u t t h e y a r e conducting Business to Fresh blow to Indians as Don tightens H-1B rules E x p r e s s N e w s Se r v i c e How can one ‘pass’ without clearing arrears? E XPR E SS N E WS S E RVIC E express read anti-Citizenship Amendment Act protests in Delhi’s Shaheen Bagh. “While appreciating the existence of the right to peaceful protest against a legislation (keeping in mind the words of Pulitzer Prize winner, Walter Lippmann, who said “In a democracy, the opposition is not only tolerated as constitutional, but must be maintained because it is indispensable”), we have to make it unequivocally expertise. The new rules narrow the definition of ‘specialty occupation’, making it difficult for companies and workers to avail the H1-B visa. Companies will also have to file additional documentation to prove that they genuinely need H-1B workers. The new rules will make it more expensive for US companies to bring in foreign workers under the H-1B visa programme as the minimum wage under H-1B is set to change. With confusion prevailing over whether the new rules will apply to only new visas or to existing visa holders as well, the US Department of Homeland Security will release detailed guidelines next week. Consumers (B2C) sales, which is a clear violation of the FDI policy . The letter noted that it is an open secret that deep discounting is funded by investors of these companies. “They (e-commerce firms) are not the losers, the ultimate loser is the Government,” it pointed out adding that the government must appoint a special task force to monitor the sales and recover the shortfall in GST and other taxes on the basis of the original value of the products sold on the sites. He also drew attention to the fact that these multi-national companies have been making losses after losses for the past many years but they still manage to continue their regular operations unhindered and even have the wherewithal to conduct seasonal sales. Kick-off Sport retunrs with football I-League Qualifier, beginning in Kolkata on Thursday, is the first national-level event to be held in India after the lockdown. Ten teams will take part in a bio-secure environment | P11 today’s IPL match hyderabad vs punjab KXIP have played good cricket, but have not been able to close matches and are bottom of the table. Can SRH, who are not clicking as a unit, get back to winning ways against Punjab? Odds : srh 9/10 | kxip 11/1o Live: Star Sports1/Hotstar @ 7.30PM
Express Network Private Limited publishes thirty three E-paper editions of The New Indian Express newspaper , thirty two E-paper editions of Dinamani, one E-paper edition of The Morning Standard, one E-paper edition of Malayalam Vaarika magazine and one E-paper edition of the Indulge - The Morning Standard, Kolkatta.

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Last week, a woman won a lawsuit against Louisville Slugger's parent company over the death of her son in 2003. Her son was pitching in a high school game and a ball came back to the mound and hit him in the head.
The Patch family sued the maker of the bat for not placing a warning label that balls coming off the bat are dangerous. This is ludicrous. The bat was made within the specifications of the league and governing safety body, and it was found not to be a non-defective bat. That group doesn't have to pay the penalty. The bat company does.
This infuriates me to no end. This is apparently the second lawsuit that they've been forced to pay damages. They have a third waiting in the wings. Somebody sue these rules making organizations. These bats aren't defective, they are built to the safety factors studied by the rules organizations and bat companies.
Rabble rabble rabble rabble
(Saw the Outside the Lines piece on it today, hence the delayed reaction to the news)

domain: law


Meet Clare De Guzman, Director of Client Services for Everise Philippines. Clare has been with Everise for over a year and transitioned to working at home when the community quarantines began in her area. In this episode of Live From Our Living Room, Clare shares how she balanced her time with work and family at home and talks about her empowering experiences as a woman working in Everise.
As a Director of Client Services, Clare is no stranger to maintaining schedules. Working from home was challenging at first, but Clare eventually managed to balance her time between work and family by following a schedule that lets her fulfill her work duties while carrying out her responsibilities as a mother.
“I’ve been with Everise for a year and four months now. Balancing work and my time in the family – it’s good that I’m at home, but it’s still tough. I think the best thing that I try to do each day is to keep a schedule. It’s just really a matter of being conscious of the time."
Working at home gave Clare more time to learn new hobbies and try out new activities with her family. She spent her additional time at home by brushing up on her cooking skills and bonding with her family by watching movies together.
“I have been cooking a lot. I’m not the best in that field, but I can say that I can do a decent one for my family. And then the other thing that I’m having fun doing now with my family, given the whole quarantine, I have more movie nights with my family and the boys.”
Clare also talked about her firsthand experience as a female leader in Everise and how she felt Everise’s celebration of diversity, especially during meetings and events. She even recalled her past experiences explaining how different the culture at Everise was and how it changed her for the better.
"Being a female leader in Everise is something that I truly appreciate. Cultural diversity & gender equality is something that is driven by other companies, but I can truly say that in Everise, it is something that truly exists because I have experienced it. There have been a few instances in the past wherein I’m the only Filipino or the only female in the meeting, usually, I would be quiet. I would just be there and when I would get asked, I would just answer.”
Clare ended the interview by sharing her appreciation for Everise’s culture and how it made her feel valued. For Clare, Everise's empowering diversity and inclusion helped her become a better leader and helped her realize her potential.
“I know that I am empowered, that people listen to me, and I am being appreciated because of my capabilities and the value that I bring into the business. It’s something that I truly appreciate in Everise.”
At Everise, we ensure that we put the spotlight on the people behind our success. That’s why we are featuring employees from different walks of life and shedding a little light on the people of Everise. Learn more about our award-winning culture and our people just like Clare today!


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Der Kunde wird DaoPay anrufen oder eine SMS schicken, um die Zahlung vorzunehmen. Details. ID. Erfassungsart der Zahlungsinformation. Eine dieser Optionen ist Daopay. Bei Daopay zahlt der Kunde mit seiner Telefonrechnung. Wie dies funktioniert und was der Kunde beachten muss, verrät der. The following data can be used for test payments: Please note: Email confirmations are only sent for SEPA/Direct Debit payments. SEPA/Direct Debit. <
Was ist Daopay – Bezahlen über die TelefonrechnungDer Kunde wird DaoPay anrufen oder eine SMS schicken, um die Zahlung vorzunehmen. Details. ID. Erfassungsart der Zahlungsinformation. Wie viele Sterne würden Sie DaoPay geben? Geben Sie wie schon 18 Kunden vor Ihnen eine Bewertung ab! Ihre Erfahrung zählt. The following data can be used for test payments: Please note: Email confirmations are only sent for SEPA/Direct Debit payments. SEPA/Direct Debit.
Daopay Experienced in Global Payments VideoDaoPay - Kaufe Credits mit Deinem Telefon! DaoPay | followers on LinkedIn. We provide over + tailored-made payment solutions to various online businesses worldwide. DaoPay - the way to pay. | DaoPay is an Austrian licensed payment. DaoPay GmbH. DaoPay operates as a fully licenced Payment Service Provider monitored by the Austrian FMA (Finanzmarktaufsicht). That gives the company permission to offer its services internationally – a licence very few market players have. DaoPay meets the highest standards issued by the Austrian government. What is DaoPay? Founded in by Peter Krapfl as DaoPay, later Daotec Payment GmbH and finally renamed to the DaoPay GmbH - is an European Company that provides pay-by-call transactions to their more than 2,, consumers (so-called DaoPayers) available in more than 60 countries around the world. With DaoPay, customers can charge the purchase of your product to their phone bill. All they need is a phone - mobile or landline. They just dial a service number or send a SMS and without ever giving away any personal or financial information. DaoPay is a service that enables fast and easy payments of digital content and online service on an international level. What differentiates DaoPay from other similar providers are the principles on which it stands. The founder of DaoPay, Peter Krapfl, was a disciple of a Daoist monk and used the wisdom acquired as a staple of his business.
DaoPay Phone Payments works with all phones. Give your user the choice to purchase via mobile or landline phone.
Landline billing is widely used when consumers access their favorite browser game or website from home and want to have the comfort of using their home phones to access your digital product or service.
Users can still choose between the established habit of making a call, the popular option to text or the quickest way of entering their mobile phone number on-screen.
Direct Carrier Billing Direct billing is the quickest way to pay online and is also known as web billing, wap billing or mobile payment.
It is the most recent payment option offered by more and more mobile operators in different countries. DaoPay implements direct carrier billing technology to offer various types of payment flows: asking the customer to enter the mobile number, texting a message or calling a toll-free or local number.
Voice payments are made by calling a premium rate number. With voice payments a wide range of price point is available. We are able to bill to the second of a call so you may charge any price you want for all countries we offer services in.
If you are a casual player that prefer to keep a low budget, then Daopay and similar methods will be just alright. Mobile payment methods are expanding with the advance of technology, also in online casinos.
What exactly is DaoPay? How to deposit using DaoPay? There are many alternative phone bill methods that are more popular throughout Europe: Boku — Pay by Mobile Pay by Phone Siru Mobile Paylevo Zimpler These methods work the same way: you authorize a payment to your casino, that will be charged later on your phone bill.
What are the gaming sites that accept DaoPay? Wargaming Wargaming is a website designed specifically for war-play gamers.
Nexon Nexon is a Korean gaming company with headquarters in Japan and offices across the world. Imvu Imvu is more of an avatar social community platform than a gaming website, however, it allows you to use Imvu credits for your in-game purchases of items created by other members.
What are the advantages of DaoPay? Daopay Casinos. Trustabiity 9. Speed 6. Support 8. Availability 0. Fees 8. Ease of Use Pros Fast deposits, paid on your phone bill.
Easy to use. No registration needed. No need to disclose your financial details. Extra benefits such as: Daopoints and other promotions.
Cons Not available at online casinos yet. No withdrawals available. Contact us. Toggle navigation. DaoPay helps ecommerce merchants to accept payments online.
Unique Selling Points. Supported Payment Methods. Card Payment Methods. VISA Visa is one of world's best known online payment methods and largest credit card brand.
Debito Bradesco Debito Bradesco is a "real time bank transfer" payment option available for Bradesco Bank users in Brazil. MasterCard MasterCard is one of world's best known online payment methods and dominant credit card brands.
Maestro Maestro is a multi-national debit card service owned by MasterCard that was founded in Alternative Payment Methods.
Carrier Billing Carrier billing lets wireless subscribers place the cost of a purchase for a digital good on their monthly phone bill.
IVR Billing IVR Billing is a payment solution where customers or end users call a local phone number and be billed on a per-minute or drop-call basis.
Bank Transfer A bank transfer is an offline or online initiated transfer of funds from the shopper's bank account to the merchant's bank account.
Klarna Klarna allows shoppers to buy now and pay later. Giropay giropay is one of the popular online payment methods in Germany.
Przelewy24 Przelewy24 is a secure and fast online bank transfer service linked to all the major banks in Poland. Digital Wallets. PayPal PayPal is the online payment method that enables people to send money and to shop online without sharing financial information.
Money e-Wallet Yandex. North America Oceania South America. Europe Middle East. If you follow us, we like it.
Stay Tuned. Stay Ahead. Subscribe Now. Salutation Select Mr. First and Last Name. Smart thinking. Please drop your contact details below.
We will contact you within 24 hours.With DaoPay, customers can charge the purchase of your product to their phone bill. MasterCard MasterCard is one Daopay world's best known online payment methods and dominant credit card brands. DaoPay implements direct carrier billing technology to offer various types of payment flows: asking the customer to enter the mobile number, texting Gamescom 2021 Programm message or calling a Forgeofempire or local number. In return, they receive a confirmation message stating the costs. Using DaoPay Phone Payments will give you an option to manage transactions by Daopay carrier billing. Start the registration. This website Cvc Maestro cookies to improve your experience. Merchants receive instant confirmation and are guaranteed of payment. He created an optimal payment tool, which has since become integrated into various platforms accessible to billions of users in more than 72 countries. Stay Tuned. Wargaming is a website designed specifically for war-play gamers.

domain: finance


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Molon Labe! the Movie: An Oath Keepers Nation-Wide Call To Action
by Elias Alias, Oath Keepers editor * February 25, 2013
We are going to talk about Molon Labe! the movie, but first, allow me to just say that I am chuckling up my sleeve in the wake of the Obama Administration’s all-out assault on the Constitution and its Second Amendment. Why? There are several reasons. For one thing, Obama has done more for gun sales than anyone in history.
The Oath Keepers recently held a convention in Las Vegas, NV, open only to police officers and sheriffs in which former sheriff (and current congressional candidate) Richard Mack discussed how the 168 attendees could reacquaint themselves with their oath to the Constitution and their own protection when they carry out their duty. One of those duties include issuing a warrant for the arrest of Barack Hussein Obama.
U.S. Military Being Indoctrinated To Kill Their Own _ For The Banking Cabal’s New World Order Scheme!
Oath Keepers is putting up a billboard right outside the main gate of Ft. Leavenworth Kansas to respond directly to the Small Wars Journal article by Leavenworth instructor Colonel Kevin Benson which paints the Tea Party movement as a future military opponent during domestic CONUS operations by the U.S. military. You can read more on that article here and here. Here is the billboard we are putting up:
All obstructions to the execution of the Laws, all combinations and associations, under whatever plausible character, with the real design to direct, control, counteract, or awe the regular deliberation and action of the constituted authorities, are destructive of this fundamental principle, and of fatal tendency.
The Democratic-controlled 2010 Congress voted to strip $11.9 billion in long-term food stamp financing in a Peter-to-Paul stunt to pay for emergency aid for state budgets. And the Senate has been aiming to cut another $2.2 billion in stamps to finance child nutrition reform. New York Times
U.S.S. Economic Titanic has already hit the economic ice-berg and is sinking. Arguing over who should be the next captain is not going to save us. Even if we replaced the entire leadership staff, by firing all of Congress, that also won’t save us. Those who have served in the infantry know the old saying “embrace the suck,” which means to accept reality and deal with it. Well, we need to dispense with false hope, accept that an economic collapse is coming, embrace the suck, and deal with it. As Patrick Henry said, it is better to know the worst, and provide for it, than to delude ourselves with false hope.


Online public input needed to prioritize parks and trail needs.
Parks and Recreation is asking citizens to share their opinions about city park and trail priorities on the City of Duluth Parks website. The City of Duluth completed a comprehensive Parks Master plan in December 2010 and is completing a Trails and Bikeways Master Plan later this year. The people of Duluth, as part of the Parks Master Plan process, stated the need for additional resources on the city's parks and trail/bikeways systems. The City would like to know what you love about the city's parks and trail/bikeways system and how do we build a parks and trails/bikewaus system that we can afford. In addition the City would like to find out from the public what you would like to see invested in and completed if there were extra resources/funding available.
To access the Parks and Recreation online survey form go to www.duluthmn.gov/parks click on "citizen input form". Citizens will be able to submit their opinions until July 23.
For further information contact Parks and Recreation at 218-730-4312.
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It was the year that is fifth for a downturn in Nevada’s web revenues for fiscal 2013, based on the Gaming Control Board
It absolutely was bad news and kind of good news for the Silver State’s gambling enterprises when Nevada’s Gaming Control Board circulated their annual Gaming Abstract Report late last week. The bad news was that Nevada’s 263 combined casinos experienced a fifth straight 12 months of economic internet losses; however the good news is that their actual intake revenues increased a tad contrasted to 2012.
However, a web loss is a net loss, and fiscal 2013 was a little bit worse than 2012, having a final tally of minus $1.348 billion,compared to $1.212 billion in 2012.
It is all the main baby step recovery process from Nevada’s massive turndown through the nation’s recession, which definitely hit this area that is casino-centric since 2009. In fact, fiscal 2008 had been the time that is last’s casinos overall showed a web revenue, and that was for $721.1 million. The following year, the state took its biggest hit, with a $6.8 billion internet loss for casinos statewide. Ouch.
The Las Vegas Strip naturally sets the rate when it comes to Nevada video gaming, and a small 1.7 percent revenue jump through the final fiscal year merely wasn’t enough to go out of a profit; overall, Strip casinos marked a $1.5 billion loss for the year. But once again, some silver lining here; that loss e Continue reading Year Nevada Casinos Can’t Win for Losing for Fifth Straight


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Meat and burger connoisseurs in Singapore are literally spoilt for choice because outstanding options are aplenty if you know just where to look. Whether it is beef, pulled pork, fried chicken or even portobello mushrooms you fancy, there is surely something to tickle your taste buds.
Here is our guide to the best burger joints in Singapore that all passionate meat lovers will appreciate. Think massive stacked burgers overflowing with meaty juices and oozing with melted cheese. Ignore the given utensils and get right in there with your bare hands—this is real-deal rustic dining at its best.
If you are not salivating right now, then you must be vegetarian.
Probably only known to those who stay in the west of Singapore, Pandan and Teban Gardens are two underrated neighbourhood districts in Jurong East. As secluded as these places may seem to the rest of Singapore, there are a couple of hidden gems in the area that are worth exploring.
Ranging from humble eateries and hawker stalls to restaurants and even a cosy ice cream parlour, Pandan Gardens and Teban Gardens offer a decent selection of food choices for residents of Jurong East and those who are working near the area.
Here are 9 Eateries And Restaurants To Check Out At Pandan & Teban Gardens. READ ON
For as long as adulthood and monthly bills started becoming a concern to us, nothing has helped alleviate that miserable feeling better than an ice-cold beer or a punchy cocktail at the end of a stress-filled workday. Yet, necessary as they are, alcoholic drinks do not come cheap in Singapore.
But did you know that besides the bar-laden enclave of Clarke Quay, Robertson Quay and Boat Quay, there lies a number of excellent bars in town with some unbelievable happy hour deals?
Forget idling around in your mundane office clicking on random icons on your computer to make yourself seem busy. Just get your work done and countdown to Happy Hour! Here are 10 Sensational Happy Hour Spots On Orchard Road That You Need To Know About.
Cheese is a comfort food for some, and an essential for many. Whether it is a pizza featuring a mixture of cheeses, a simple macaroni and cheese overflowing with luscious cheese or even roti prata with a slice of cheese in it, one fact still remains—we absolutely love it.
This gooey, salty and luxurious treat is one of the most versatile ingredients around that goes with pretty much anything, but for hardcore foodies and cheese lovers like us, we all know that the best way to truly appreciate cheese in its full glory is to have it as it is—paired with perhaps a robust wine or dried fruit.
Well, the good news is that there are many gourmet stores and cheesemongers in Singapore, allowing us better access to fine cheeses from around the world.
Serving up an impressive variety of imported artisanal cheeses from mild cheddar to the funkier taleggio, here are 10 speciality cheese stores in Singapore you can depend on for your next cheese and wine get-together.
Chicago is the third largest city in the United States of America and is interestingly home to the only river in the world that flows backwards. The Windy City is famous for inventing the very first Ferris Wheel, gorgeous skyline, Chicago-style deep-dish pizza and much more.
From historically rich Art Institute of Chicago to the visually striking masterpiece Cloud Gate, here are 6 Must-Visit Attractions in Chicago that you must include in your itinerary.
Sushi is a very big part of Japanese food culture and in Singapore, we are blessed with many great Japanese restaurants that are able to satisfy our sushi cravings. These Japanese restaurants range from affordable to mid-tier and right up to the fanciest restaurants that will cost you an arm and a leg when you dine there.
We have heard of sushi dishes that come with exorbitant price tags but not all of us are able to afford that kind of luxury on a daily basis. Then again, who says that good sushi has to be expensive?
If you are looking for good sushi bars in Singapore serving sushi at wallet-friendly prices, carry on reading this guide to find out more. READ ON
Beyond anything else, Penang is known to be a food paradise with some of the best street food in Southeast Asia (we may be biased). Even tourists would have heard of the famous Hokkien Mee, Penang Char Koay Teow and Curry Mee.
So much has been said and written about Penang’s amazing street food but what most people may not be aware of, are the different local desserts they can find in Penang as well. Aside from the well-known Cendol, there is still an array of sweet treats to try when you are there.
For all you sweet tooths out there who are visiting Penang soon, here are 9 Local Desserts In Penang You Must Try. READ ON
Whether you are planning for a first date or a special occasion with your significant other, many people struggle to settle for the perfect romantic spot where they can impress their date.
However, date nights do not have to be glitzy and glamorous. Sometimes, a perfect evening is simply enjoying each other’s company over a good dinner where you are surrounded by nature, a warm candlelight and slow jazz music playing in the background.
Treat your special someone to a wonderful meal they will never forget at these 15 Romantic Colonial Bungalows In Singapore To Dine In.

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Here you’ll find items of current interest — new programs, recent guidance, or timely reminders. Or jump to the latest news about IRS forms and publications.
IRS Strengthens Withholding Compliance Program
The IRS has stepped up its withholding compliance program by making more effective use of information reported on W-2 wage statements to ensure that employees have enough federal income tax withheld from their paychecks. At the same time, employers are no longer required to submit potentially questionable Forms W-4 to the IRS.
Health Savings Accounts
The Medicare Prescription Drug, Improvement, and Modernization Act of 2003 created a new, tax-advantaged way for certain people to save for health care expenses. You must be covered by a high-deductible health plan to open and contribute to a Health Savings Account (HSA). IRS and Treasury have provided guidance on how HSAs work.
Tax Benefits for Armed Forces Members
The Military Family Tax Relief Act of 2003 has various benefits related to military service. Several earlier tax law provisions gave breaks to those serving in combat areas. Tax Information for Members of the U.S. Armed Forces has links to these details and more.
Credit Counseling Organizations
The IRS is concerned that some organizations are using their tax-exempt status to skirt consumer protection laws. Get the details through this IRS consumer alert.
The IRS issued guidance on several tax issues related to medical care during 2003, some related to the deductibility of certain expenses, others related to Flexible Spending Arrangements (FSAs) and similar employer plans. There’s also a new Health Coverage Tax Credit program that helps pay medical insurance premiums for certain workers who lose their jobs due to the effects of international trade and for people age 55 or over who receive benefits from the Pension Benefit Guaranty Corporation. Knowing how these rules work may get you some tax benefits for your medical care dollars.
Tax Shelter Updates
Milestones in the IRS campaign against abusive tax avoidance transactions.
Why Pay Taxes? — The Truth about Frivolous Tax Arguments
The Truth About Frivolous Tax Arguments (PDF 405K) addresses some of the more common false “legal” arguments made by individuals and groups who oppose compliance with the federal tax laws. These arguments are grouped under six general categories, with variations within each category. Each contention is briefly explained, followed by a discussion of the legal authority that rejects the contention. The second section deals with frivolous arguments encountered in collection due process cases. The final section illustrates penalties imposed on those pursuing frivolous cases.
RRA 98 Joint Congressional Review
The IRS Restructuring and Reform Act of 1998 (RRA 98) required five annual reviews by the Joint Committee on Taxation of the agency’s progress in meeting its strategic and business plans, in improving taxpayer service and compliance, on technology modernization and on the latest tax filing season. Commissioner Everson testified at the final review on May 20, 2003.
See You in Court?
Why do some tax cases end up in court? How does the IRS determine which cases it will pursue? In an April 24, 2003, address to the Tax Court Judicial Conference, then-IRS Chief Counsel B. John Williams spoke on his approach to designating cases for litigation. His comments give insight into this aspect of tax administration.


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We finished up our summer dance camps last week! We had fun in Stars & Stripes Jazz Camp, Fun in the Sun Jazz, Princess Ballet, Teeny Bopper Tap, and Hip Hop. It was a good way for newcomers to try out dance styles and it was good for current students to get some dancing in over the summer break.
Here, are some photos. To learn more about us and to see more photos, like us on Facebook “Downtown Dance Lewisburg PA.”

domain: hobby


Eldin Jakupovic did not suffer a serious injury during Saturday's defeat to Sheffield Wednesday, Hull have confirmed.
The goalkeeper took a blow to the head from Reda Johnson moments after spilling Miguel Llera's corner into his own net to gift Wednesday their second goal in a 3-1 win.
Jakupovic was stretchered off in a neck brace and taken to hospital for tests.
Rob Price, Hull's head of medical services, told the club website: "Eldin received treatment for a facial injury on the pitch, and was taken to the stadium's medical room on a spinal board as a precaution.
"At no time did Eldin suffer any loss of consciousness, and he was completely responsive throughout.
"He was then taken to Hull Royal Infirmary for further examination, where all results thankfully came out as normal.
"Hull City AFC would like to thank all paramedics involved and medical staff at Hull Royal Infirmary for their work."


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Luxury village hotel nearby Eindhoven Airport
What makes us unique
The premise of the culinary package is enjoying the food and drinks at Hotel 46.
Hotel 46 offers both the business and recreational guest plenty of opportunities for a successful conference!
Delicious food and drinks at restaurant Craft
Enjoy regional products and an attractive atmosphere.
Visit the ''Brabantse Kempen"
Make the most of our Cyling & walking package and enjoy the beautiful area with countless cycling routes and walking routes.
Luxury spacious rooms
Enjoy our Luxury rooms with comfortable box springs.
We serve an extensive and varied breakfast buffet with fresh regional products in our restaurant.
Specials & news
Park, Sleep & Fly Eindhoven Airport
Do you fly via Eindhoven Airport? Take a look at the Park, Sleep & Fly package of Hotel 46 and get a comfortable night before or after your trip! Free parking on our parking place, only minutes away from the airport.Check out this package
Make time for each other and relax in our luxurious and comfortable rooms. Surprise your partner on arrival with romantic rose petals and a glass of bubbly wine in your room. End your stay with an extensive breakfast buffet and check out later, at noon!Read more
Delicious high tea
Would you like to enjoy a lot of tea and tasty dishes together? Check out our High Tea package! An excellent opportunity to catch up with family or friends!Check it out


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Please Note - Updated Logline for episode #201
You're the Worst
Season 2 - Episode Descriptions
Episode 1 / Production #201 - "The Sweater People" (Airs September 9, 10:30 pm e/p) -
A newly co-habitating Jimmy and Gretchen avoid a life of domesticity by partying non-stop. Edgar obsesses over Lindsay while an oblivious Lindsay makes a desperate attempt to reconcile with her husband. Written by Stephen Falk; directed by Alex Hardcastle.

domain: entertainment


When making modifications, aircraft operators and maintainers must take care to ensure electric systems are not overloaded, Australia's CASA notes in a recent airworthiness bulletin. According to the bulletin, up-to-date electric load analysis records must be maintained for individual aircraft. It outlines specific responsibilities for aircraft owners and registered operators, CAR 35 authorized people and licensed engineers.
You can read more from CASA's latest briefing here. It covers topics from night vision to runway incursions and pilot safety training.


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§ Mr. Hawksley
asked the Secretary of State for the Environment when he will take steps to permit the Parliamentary Commissioner for Administration to investigate complaints against new town corporations.
§ Mr. Tracey
As stated in the Government's White Paper, Cmnd. 9563, published in July of this year, legislation to amend the Parliamentary Commissioner Act 1967 will be introduced, in due course, to extend the jurisdiction of the Parliamentary Commissioner for Administration to about 50 non-departmental public bodies—including new town corporations.


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Dolly Parton is embarking on her first U.S. tour in more than 20 years, hitting 60 cities throughout the summer and beyond. On Thursday, Tanglewood confirmed that one of those appearances will be at their festival.
The country music icon will play Tanglewood’s Koussevitzky Music Shed on Friday, June 17 at 7 p.m. Parton is one of the great songwriters in country music history, with 25 hits that have reached number one on the Billboard country charts and seven Grammy awards. Parton’s work includes songs like “Jolene,” “Here You Come Again,” and “I Will Always Love You,” which was re-recorded in 1992 by Whitney Houston.
Tanglewood also announced a performance by Keith Lockhart and the Boston Pops Swing Orchestra on Saturday, September 3, complete with a dance floor, to close out the 2016 season.
Tickets for these performances will go on sale Monday, April 4 at 10 a.m. via Tanglewood’s website.

domain: celebrity


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Posters is immensely superior and makes a superior wall decoration, this product dimension isand the price is $0.00. If you're trying to see top recommendedPosters with inexpensive price, the poster is the nice deals for you.
The color is a bit different than shown on the ware print, a bit more than just monitor differences. This poster argues that carrying the product around in your head increases stress and diminishes productivity. This item is clean, it's deep and every page is a mini-escape to another energetic diversion. This is in faithful shape, the colors are thrilling and quality is grandiose.Posters was done primarily because each production displayed only one film on one screen. This one is a whole sized poster, printed on famous paper, with glossy color and twinkling finish. A unique feature of this produce is that all fractal posters and goods can be customized obtain you. This poster is a imposing good with popular service and definately reccomend this item.Posters itself is very elegant, you get what you see on the screen.

domain: design


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Gene expression differs substantially among individual cells of the same type. We speculate that genes that are expressed in all but a portion of cells of a given cell type would be likely essential and required for either the cell survival (housekeeping) or for the cell type's unique structure and function, enabling the organism to survive. Here, we performed RNA-seq of 20 mouse podocytes using the Fluidigm C1 system and identified 335 genes that were expressed in all of them. Among them, 239 genes were also expressed in mesangial and endothelial cells and were involved in energy metabolism, protein synthesis, etc., as housekeeping genes. In contrast, 92 genes were preferentially expressed in podocytes (over five-fold versus expression in mesangial and endothelial cells) and are, therefore, the essential candidate genes specific for podocytes. Assessments by bioinformatics, conserved expression in human podocytes, and association with injury/disease all support the essentiality of these genes for podocytes. Factually, 27 of the 92 genes are already known to be essential for podocyte structure and function. Thirty-seven novel genes were functionally analyzed by siRNA silencing, and we found that a deficiency of 30 genes led to either cytoskeletal injury (FGFR1, AOX1, AIF1L, HAUS8, RAB3B, LPIN2, GOLIM4, CERS6, ARHGEF18, ARPC1A, SRGAP1, ITGB5, ILDR2, MPP5, TSC22D1, DNAJC11, SEPT10, MOCS2, FNBP1L, and TMOD3) or significant downregulation of CD2AP and synaptopodin (IFT80, MYOM2, ANXA4, CYB5R4, GPC1, ZNF277, NSF, ITGAV, CRYAB, and MTSS1). Thus, the list of genes essential for podocyte cytoskeletons is expanded by single-cell RNA sequencing. It appears that podocyte-specific essential genes are mainly associated with podocyte cytoskeletons.
Keywords: cytoskeleton; gene expression; podocyte.
Copyright © 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

domain: medical


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Added May 14, 2011
Hamilton, New Ze...
Pattern 114, long sleeve blouse 04/2010
I got rid off the loop at the back of the shirt and added black pipped bias.
I was disappointed by the pattern that I bought on here, once printed the test square supposed to measure 10×10cm was 11.3×11.3cm, be warned the pattern you get through the website is not up to scale!
I used 100% cotton made in Japan with a paysley pattern, bought from Spotlight (NZ)
Burda Style Videos
Help us count down our TOP 10 most popular videos and get inspired!
Meg got an inside look into our new course, and see why she thinks you need to register too!
Leopard print, stripes, and mod coats for fall.
Sewing & Techniques
Check out this step-by-step tutorial on how to sew these overalls with a modern twist!
This course will guide you through the process of creating an 8-piece Lingerie Collection!
You must allow our "request for permission" request to login to Burdastyle with Facebook.


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Captain Claude Lambert has been a member since 2003, but this year he decided to join the Sustainer Circle because “I love Leelanau County, and it’s one place I can come back to and it’s still the same,” he says. The 30-year-old captain has done tours all over the world and stopped into our office in late June. He said he wanted to join the Sustainers Circle before deploying to Afghanistan in late July. He is with the 4th Brigade, 82nd Airborne Division out of Fort Bragg, NC. “Whenever we can, we come to Leelanau,” says Claude, father of two. Claude’s mother owns a house near Sugarloaf, and he and his family stay there when in the area. “I like how proactive the Conservancy has been in preserving land. I’ve also been on some docent-led hikes and appreciate that the Conservancy is educating people about nature and why we need to conserve land. I’m joining the Sustainers Circle so that the Conservancy can preserve more of it.”
Thanks, Claude, for working to make the world a better place, both locally and globally. Conservancy Sustainers do just what their name implies—they sustain our organization with their annual gifts. The dependable support from this deeply committed group has allowed us to take on big projects and to hire a professional staff needed to carry out our mission. Sustainers make a non-binding commitment to contribute to our operating fund annually. Giving levels start at $500. Benefits include special recognition in our publications, and special hikes/gatherings where Sustainers can meet our staff and others who share their commitment to our work.


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About Blueprint Home
Since its inception over twenty years ago, Blueprint Home has been offering fresh, elegant, modern and affordable style for your home. Offering a boutique effect specializing in personal care and guidance, this urban shop can change the way you live your life at home. Whether you live downtown, in the suburbs or by the lake, your home can be fashionably and stylishly transformed into your vision of perfection.
With our help, it will rival any featured home in the best design magazines with one difference; all the personal touches that make your home amazing, will belong to you. Our web site is a peek into our world but more importantly, a gate way into what can lie ahead for your world at home. We encourage you to visit our web site as often as you wish, but for the full impact, please visit us at our store at 1301 Wellington Street West in the heart of Ottawa's trendy Wellington Village.


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My family loves Christmas Eve about as much as we enjoy Christmas Day and the whole Christmas season. This year Christmas Eve dinner consists of spaghetti, garlic bread and for dessert lemon brownies.
I am not a huge spaghetti fan but my family is. My husband loves pasta so I searched for an easy spaghetti recipe and found a One Pot Spaghetti recipe.
One Pot Spaghetti
Next, the garlic bread. I found an easy and delicious cheesy garlic bread recipe at http://www.cookingclassy.com/cheesy-garlic-bread/ that is definetly worth the try.
Cheesy Garlic Bread
I love most lemon flavored desserts. I found a lemon brownie recipe at http://kim-thislittlelifeofmine.blogspot.com/2014/08/quick-and-easy-lemon-brownies-3.html?m=1
1 box lemon cake mix
1 box vanilla instant pudding (small box) *lemon would probably be even better!
1 1/2 cups milk
1 cup confectioners sugar (or more if you want more glaze)
zest of one lemon
lemon juice - enough to reach desired glaze consistency


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As an Amazon Associate I earn from qualifying purchases.
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- Australian Virgin Charcoal for odorless indoor cultivation. Ul, etl certificated. The results come from years of research and development that is always expanding to be able to help first time and beginner growers through the growers' journey. Powerful fan moves air speeds up to 2550 RPM.
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This regulation also helps prevent any potential nutrient burn to your plant! Premium quant-led grow light - led lights specialty manufactured by vivosun with samsung lm301 diodes for full spectrum light, ce, ideal for all stages of growth. The industry's most durable grow tent – heavy duty1680d oxford cloth exterior makes this tent extremely durable; stitching for strength and light protection works to keep in 99% of all light and reduces smell. Silent functions mean that no fans cause noise pollution in your home.
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domain: agronomy


Dedicated to disseminating news & information not found in mainstream media....
BEIRUT - The terrible situation in Gaza focuses today on whether or not the parties can agree on a humanitarian
The battles for Kurdish and Palestinian statehood, or the tensions among different regions of Syria, Iraq, Yemen, Libya and Sudan are more deeply anchored in movements for national rights, autonomy or self-determination that have long been suppressed by the modern Arab or Israeli security state, argues Rami G. Khouri.
cease-fire that would also trigger negotiations on deeper contested issues in order to try and resolve the underlying conflict between Israelis and Palestinians. This conflict has some common elements with the chaotic situations in Syria, Iraq, Yemen, Libya and other Arab lands.
Anyone trying to analyze these many conflicts in our region must separate the short-term reactions that drive some people from the more long-term and structural processes normally associated with state-building. So I would place the spread of the “Islamic state” and other hardline Salafist-takfiri movements in Syria-Iraq in the category of short-term, transient movements that were born from the chaos of recent years only; they will not endure, because they lack deeper anchorage in the societies of these countries.
The battles for Kurdish and Palestinian statehood, on the other hand, or the tensions among different regions of Syria, Iraq, Yemen, Libya and Sudan are more deeply anchored in movements for national rights, autonomy or self-determination that have long been suppressed by the modern Arab or Israeli security state. The process of sorting out such conflicting demands between the central state and the various identities of its citizens often takes many decades, some serious constitutional litigation where available, and a brief or prolonged civil war. The common denominator among all such situations is that wars end and stable statehood takes off only when all the citizens feel that their interests are taken into account in the management of statehood.
The Palestinian-Israeli conflict has experienced recurring and increasingly vicious bouts of violence because the rights and interests of the Palestinians have consistently been neglected in favor of the rights of Israelis to their own secure state. This lopsided situation that favors Zionist over Palestinian Arab interests has been consistently supported by the major Western powers, including this week in the American ceasefire proposal that reflects Israeli aims much more than it meets Palestinian demands.
As long as this situation persists, it will be impossible to secure a credible short-term ceasefire or to start addressing the deeper underlying issues that define the century-old conflict between Zionism and Arabism. Resolving this conflict requires first of all framing its core elements correctly, which repeated American mediators — whether cloaked Zionists or simply well-meaning amateurs — have never done.
Any serious attempt to end this round of fighting and seek to ensure that it is never repeated must start by grasping the three elements of the conflict that matter to both sides, with equal magnitude — not with the John Kerry approach that frames a ceasefire through the lens of Israeli wishes to remain in Gaza during a ceasefire to destroy the tunnels and other resistance elements that Hamas and allied Palestinians have used to fight back against Zionism’s denial of their rights.
The three fundamental elements that must be dealt with in this case include: 1) stopping the fighting and allowing both sides to go about their daily lives without the threat of being attacked or militarily occupied; 2) implementing the measures agreed in the last cease-fire agreement in 2012 that removed the physical and political siege that Israel, Egypt, the United States and others had imposed on Hamas and Gaza; 3) grappling seriously with a permanent Israeli-Palestinian peace negotiation that addresses ending the condition of Palestinian refugeehood as fiercely as it addresses the Israeli demand for Arab recognition and security. This means going back to the events of 1947-48, when the conflict took its present shape of Israeli statehood and Palestinian refugeehood.
This kind of approach that honestly acknowledges the critical issues for both sides is so tough that it has never been attempted seriously. It was the key to successful breakthroughs for peace in other instances of profound nationalist battles, such as in Northern Ireland and South Africa that mirror the identity and rights battles we witness all around the Middle East today.
The Palestinian resistance groups fighting from Gaza, and the thousands of Palestinians demonstrating in the West Bank, are the direct descendants of Palestinians who were made homeless and stateless due to the birth of Israel in 1947-48. Grasping and resolving these root issues is very hard to do for Zionists and Israelis, who refuse to acknowledge their major role in the refugeehood of the Palestinians, along with ignoring that no peace will come to anyone unless the 1947-48 root causes of conflict are resolved equitably.
If Israelis do not see this in the eyes, tunnels, rockets and charred bodies of dead Palestinian infants, and continue with the United States to insist on prioritizing Israeli security over a more balanced approach to ensuring the dual rights for both peoples, then these savage rounds of violence will persist for years. That would be adding stupidity to savagery.
Rami G. Khouri is Editor-at-large of The Daily Star, and Director of the Issam Fares Institute for Public Policy and International Affairs at the American University of Beirut, in Beirut, Lebanon. You can follow him @ramikhouri.
Copyright © 2014 Rami G. Khouri - distributed by Agence Global


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- Ragione Sociale
- SOCIETÀ COOPERATIVA SOCIALE AZALEA ONLUS
- Via Pepe, 5 - 20851, Lissone (MB)
- Telefono / Cellulare
- 039 480202, 039 463535, 340 0797888
- Andra Torgano, Casagrandi Luca
- Sito web
Who we are
A type B cooperative, founded in 1994, whose activities, apart from green house and nursery production are green areas maintenance in public and private areas, civic, industrial and hygienic cleanings, cut flowers sale.
Produces seasonal flowers and small vegetable garden plants in temperature-controlled greenhouses, cultivates perennial plants and potted outdoor plants and manages the preparation and sale of cut flowers for cemetery services in Lissone.
Azalea, apart from being committed to green maintenance, also plans and designs flowerbeds and lawns, irrigation systems, urban planting of trees, green terraces and tree pruning with both aerial structures and tree-climbing technique.
Also Azalea provides flower compositions for weddings and other special occasions.
In the past few years, the cleaning services were developed, both in private and industrial settings.