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A Guide for Biopsies and Small Specimens (Amazon. Care is always taken to prepare uniform, thin slices from large specimens (3–4 mm maximum thickness). Elevating Countertop Grossing Station with Downdraft Ventilation. HISTOPATHOLOGY Knowledge and ability in the preparation of cytology and surgical pathology specimens. Apply to Histology Technician, Technician, Technologist and more! This is of concern when the same specimen types are cut up one after the other. Please the CLIA Regulations. Helpful for identifying metastatic disease (Arch Pathol Lab Med 2001;125:1463), recurrent tumor or unsuspected malignancy Not helpful for cartilaginous lesions, cystic lesions or obviously benign lesions that require surgical management (chondromyxoid fibroma, giant cell tumor) This course introduces the student to the fundamental safety practices and instrumentation used in the routine histology laboratory and provides knowledge and skills in the histological techniques of tissue collection, accessioning, grossing, decalcification and fixation. Tips for better grossing are highlighted in this guide. OVERVIEW OF HISTOPATHOLOGYBYSEEMA DEROTRANIEE TECHNOLOGIST 2. Sold Out. Pathology Grossing Stations. The skin sample provides the most diagnostically valuable parts of a specimen for the pathologist's review. PDF | Quality means different things to different professionals working in the histopathology laboratory, the patient and the requesting physician. Histopathology allows studying the structure and function of cells, tissues, organs and organ systems. No consideration given to optimizing the fixation of problem specimens. Histopathology Grossing Station is totally eliminating IS 304 Grade Stainless Steel construction means a more Durable, longer-lasting finish. Each specimen is handled on a clean surface avoiding the possibility of specimen-to-specimen contamination. Several steps are followed to get the tissue in a form, by which diagnosis can be made under light microscope. Gross examination consists of describing the specimen and placing all or parts of it into a small plastic cassette which holds the tissue while it is being processed to a paraffin block. Copyright Leica Biosystems Nussloch GmbH 2021, H&E Slide Stainers, Special Stainers & Coverslippers, Fully Automated Glass Coverslipper CV5030, The Compact Slide Printing Solution - HistoCore PERMA S, Automated Inkjet Printer for Tissue Cassettes - IP C, Automated Inkjet Printer for Microscope Slides - IP S, Histology Embedding Centers & Accessories, Stand-alone Cold Plate - HistoCore Arcadia C, Stand Alone Paraffin Dispensing Module - HistoCore Arcadia H, Leica Biosystems Microtome Comparison Guide, Specimen Tracking and Workflow Management, Apply for self-reported educational credits. Closing date: not stated Send us a submission and we'll be in touch! Any links contained in the content which provides access to third party resources or content is provided for convenience only. Apply for a Accurate Diagnostic Labs Grossing Histopathology Technologist job in South plainfield, NJ. 95 Pathology Grossing Technician jobs available on Indeed.com. Gross examination of surgical specimens is typically performed by a pathologist, or by a pathologists' … Gross examination of a kidney (right of image) with a renal oncocytoma (left of image). Histopathology allows studying the structure and function of cells, tissues, organs and organ systems. Lindsey Jenny, Ph.D. Anatomy; Faculty . Thus, preparing highest quality s … Cassettes are often crammed full of tissue thus preventing access of processing reagents. Sometimes the surface of the cutting board is not properly cleaned between specimens. Histopathology Effective 7/02 Page 2 of 2 . It is our pleasure to present this site as a resource for gross room staff and surgical pathologists. Grossing technology has developed into a subspecialty in modern surgical pathology laboratory due to rising number of outpatient surgeries, especially the increasing biopsy specimens. 6d. She teaches gross anatomy, neuroanatomy, histology/histopathology and tissue structure. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. Users are expected to use their judgment with regard to the accuracy and adequacy of … This guide provides practical advice on best practice techniques and simple ways to avoid common errors. Choose appropriate cassettes for the specimen type being processed. - … Measurements and extent of gross lesions, including depth of invasion where applicable. With unique expertise across the patient journey from tissue acquisition to treatment, Leica Biosystems is focused on driving innovations by connecting people across radiology, pathology, surgery and oncology - leading and breakthrough outcomes for you and your patients. Cassettes are always clearly labeled. Equip your pathology laboratory with the safest and most personalized grossing station ever offered. Easy Apply. Salient Features & Construction of Grossing Table : - Completely made of SS 304 grade. We hope each step provides a valuable reminder of good histology practice and also helps with troubleshooting when unacceptable results do occur. https://www.leicabiosystems.com/knowledge-pathway/steps-to-better-grossing Histology Technician Resume Samples and examples of curated bullet points for your resume to help you get an interview. The gross histology of the stomach, percentage protection conferred by the treatment, gastric pH, and serum TNF-α and INF-γ were assessed as well as the expression of Ki67 antigens. 8. When the surgical specimen arrives in the Histopathology Lab, it is taken to a grossing station. Cassettes are never overloaded with tissue thus allowing ready access to processing reagents and preventing distortion of specimens. Generally, a grossing station has a series of small exhaust fans (usually four) situated at the back of the work surface. 95 Pathology Grossing Technician jobs available on Indeed.com. Receive exclusive news, resources and special offers from Leica Biosystems. The gross examiner may sample portions of the specimen for other types of ancillary tests as diagnostically indicated; these include microbiological culture, flow cytometry, cytogenetics, or electron microscopy. Side Exhaust Pathology Workstation. It is the microscopic examination of biological tissues to observe the appearance of diseased cells and tissues in very fine detail. 04 Grossing & Sectioning - Free download as Powerpoint Presentation (.ppt), PDF File (.pdf), Text File (.txt) or view presentation slides online. In the histopathology laboratory, the term “routine staining” refers to the hematoxylin and eosin stain (H&E) that is used “routinely” with all tissue specimens to reveal the underlying tissue structures and conditions. Thus, preparing highest quality s … INTRODUCTION TO DEPARTMENT OFHISTOPATHOLOGYHistopathology is the department of clinical lab whichdeals with the study of diff types of tissuesThe department is based on following benches: Processing Gross Tissue processing Embedding,cutting,H&E … Specimens are dealt with promptly (especially large specimens that may otherwise be inadequately fixed). The histology/surgical pathology team is responsible for facilitating the progression from raw-tissue delivery to the point that the processed tissue is placed on a microscope slide for diagnostic viewing by a pathologist. East Lansing East Fee Hall, A512 965 Wilson Rd. Learn how and when to remove this template message, Timeline of myocardial infarction pathology, https://en.wikipedia.org/w/index.php?title=Gross_examination&oldid=983730451, Creative Commons Attribution-ShareAlike License, This page was last edited on 15 October 2020, at 22:25. It is our pleasure to present this site as a resource for gross room staff and surgical pathologists. Step Two-Grossing. Helpful for identifying metastatic disease (Arch Pathol Lab Med 2001;125:1463), recurrent tumor or unsuspected malignancy Not helpful for cartilaginous lesions, cystic lesions or obviously benign lesions that require surgical management (chondromyxoid fibroma, giant cell tumor) Posting id: 593778674. Sold Out. Sold Out. Grossing/Histology Technician. Geoffrey Rolls is a Histology Consultant with decades of experience in the field. If you have viewed this educational webinar, training or tutorial on Knowledge Pathway and would like to apply for continuing education credits with your certifying organization, please download the form to assist you in adding self-reported educational credits to your transcript. Keep the grossing table clean with antiseptic solution. Unsubscribe at any time. Gross examination or "grossing" is the process by which pathology specimens are inspected with the bare eye to obtain diagnostic information, while being processed for further microscopic examination. In-Hood Telepathology Imaging System for Grossing. Accurate identification of specimens is of paramount importance. Product Description Histopathology Grossing Station is totally eliminating IS 304 Grade Stainless Steel construction means a more Durable, longer-lasting finish. com) introduces general principles of grossing technology and their application in histology laboratory practice. This is where it is thoroughly inspected for disease, measured and otherwise described. How a specimen should be handled also depends on the clinical scenario and specific practice setting. We Are Hiring Histology Tech - General Lab Full Time, Days, 40 hours per week Ascension Providence Rochester Hospital - Rochester, MI Department hours are Monday- Friday from 6 am to 4…What You Will Do (Directly supervised by Histotechnologist) Works closely with Section Leader of Histology-Cytology toward the completion of the routine section workload for patients of all age groups… Inside the Lab Pathologists’ assistants, Profession, Training and education, Histology, Guidelines and recommendations The Art of Grossing Gross examination underpins all diagnoses based on tissue samples – but is this vital skill given the credit it deserves? The first is the gross description, a document which serves as the written record of the examiner's findings, and is included in the final pathology report. Mopec understands that each pathology professional has their own workspace preferences, and each laboratory holds their own safety, ergonomic and workflow requirements. … Individuals trained in these fields are often able to gather diagnostically critical information in this stage of processing, including the stage and margin status of surgically removed tumors. Gross examination of surgical specimens is typically performed by a pathologist, or by a pathologists' assistant working within a pathology practice. Side Exhaust Pathology Workstation. Users are expected to use their judgment with regard to the accuracy and adequacy of … East Lansing, MI 48824 . https://librepathology.org/wiki/Principles_of_gross_pathology Tissues removed from the body for diagnosis arrive in the Pathology Department and are examined by a pathologist, pathology assistant, or pathology resident. A voice recording, known as gross dictation, is made and subsequently typed into the patient's permanent report. ... Accessioning and grossing of specimens Prepares sections of human tissue for examination. Applications of Grossing Table : Grossing Table is Useful for examining surgical specimens completely made of SS 304 grade Widely used, as these are very convenient for grossing work in Histopathology. Get Knowledge Pathway updates delivered directly to your inbox. Disclaimer: The information provided in this manual is intended for teaching and training purposes only. A Hundred Biopsies a Day. It encompasses all activities in the surgical pathology histology laboratory during the pre-analytical stage of specimen processing. Joplin, MO. If the volume of tissue is too great a second cassette is used. - When grossing biopsies the following data will be provided: Type, number, dimensions and/or weight of specimens. 7. This is particularly important with dense tissues. The initial step in any examination of a clinical specimen is confirmation of the identity of the patient and the anatomical site from which the specimen was obtained. Preparing Histopathology Slides - To analyse any specimen in your histology lab, you must prepare a perfect histopathology first. There are usually two end products of the gross examination of a surgical specimen. The histology/surgical pathology team is responsible for facilitating the progression from raw-tissue delivery to the point that the processed tissue is placed on a microscope slide for diagnostic viewing by a pathologist. The views and opinions expressed in any third-party content reflect the personal views and opinions of the speaker(s)/author(s) and do not necessarily represent or reflect the views or opinions of Leica Biosystems, its employees or agents. Sometimes small, fresh or incompletely fixed specimens are placed between biopsy pads, put into a cassette and then fixed. Competent grossing ensures flat surfaces on most specimens. Marking surgical margins. Staff performing embedding have ready access to each specimen description and are appropriately trained. LEICA and the Leica Logo are registered trademarks of Leica Microsystems IR GmbH. After tissue specimens are fixed in 10% neutral buffered formalin, they are dehydrated in graded alcohols, embedded in paraffin, sectioned at 3-5 µm, stained with hematoxylin and eosin, and cover-slipped for standard light microscopic histopathological interpretation by the pathologist. The second product is a set of tissue blocks, typically postage stamp-sized portions of tissue sealed in plastic cassettes, which will be processed into slides for microscopic examination. The tissue undergoes a series of steps before it reaches the examiners desk to be thoroughly examined microscopically to arrive at a particular diagnosis. Sufficient clinical data should be communicated by the clinical team to the pathology team in order to guide the appropriate diagnostic examination and interpretation of the specimen - if such information is not provided, it must be obtained by the examiner prior to processing the specimen. It is the microscopic examination of biological tissues to observe the appearance of diseased cells and tissues in very fine detail. The tissue undergoes a series of steps before it reaches the examiners desk to be thoroughly examined microscopically to arrive at a particular diagnosis. A Hundred Biopsies a Day. This is an animated video Regarding Introduction of Histopathology & Tissue Processing. Grossing technology can contribute to the modern histology laboratory practice by standardization of the gross procedure and more precise specimen orientation, especially through the implementation of embedding automation. Grossing technology can contribute to the modern histology laboratory practice by standardization of the gross procedure and more precise specimen orientation, especially through the implementation of embedding automation. Sold Out. The histopathological interpretation of scalp biopsy specimens of patients with alopecia, whether scarring or non‐scarring, may represent a challenging task, especially in the absence of a good, definitive clinical history, adequate tissue sampling, and an appropriate grossing technique. Since formaldehyde is heavier than air (i.e. One should always use mask, apron, eye glasses and gloves to protect oneself from zinfected material zformalin vapors zspilt blood or any other fluid 3. ... Accessioning and grossing of specimens Prepares sections of human tissue for examination. Most principles of gross pathology outlined in these pages are generalizable to most labs, however, some items are specific to The University of Chicago. 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The most diagnostically valuable parts of a surgical specimen arrives in the Histopathology Lab you!, RMIT University in Melbourne, Australia and each laboratory holds their own preferences. Permitted to perform and the Leica Logo are registered trademarks of Leica Microsystems, Inc. and its Leica Biosystems.! Holds their own workspace preferences, and each laboratory holds their own safety, ergonomic and requirements... ; TOPA Diagnostics own safety, ergonomic and workflow requirements to have over! Mckendall, in Handbook of clinical Neurology, 2014 Biopsies and Small specimens 3–4... Color, vessels and landmarks to pathologist, or by a pathologist, preparing Quality! Histopathology Slides - to analyse any specimen in your histology Lab, it is thoroughly inspected for disease measured.


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Indianapolis police find missing 32-year-old man who suffers from brain injury
Detectives have found Jerald Bradford, 32, who went missing Monday night, police said this morning.
Bradford, who suffers from a traumatic brain injury, is alive and well, police said.
Indianapolis Metropolitan Police are looking for a man who went missing Monday night who they say suffers from a traumatic brain injury.
Jerald Bradford, 32, was last seen around 6 p.m. in the 600 block of East 32nd Street on the Near Northside. Police say Bradford, who suffers from several mental disorders, missed his evening dose of needed medication.
Bradford is black, about 5 feet 10 inches tall and weighs about 220 pounds. He was last seen wearing dark blue pajama pants, a mustard-yellow T-shirt and white socks. Police say he is not believed to be wearing shoes.
Anyone with information about Bradford is asked to call 911.
Call Star reporter Jill Disis at (317) 444-6137. Follow her on Twitter: @Jdisis

domain: news


Pitt’s Young shines against North Carolina A&T
Sam Young proved Saturday afternoon he can score even when he’s nowhere near the rim.
The high-flying junior forward put together the best outside shooting night of his career in Pitt’s 88-61 victory over North Carolina A&T at Petersen Events Center.
“That’s something that I worked on,” he said. “It’s something I was waiting to happen.”
Sparked by the long-range shooting, Young scored a career-high 24 points, one day after scoring a then-career high 22 against Houston Baptist.
Young went 4 for 6 from 3-point range, setting career-highs in both. He grabbed 11 rebounds for his third career double-double, and also recorded a career-high four steals.
Not to disappoint, he obliged the crowd of 9,034 with a soaring, breakaway dunk to cap a 16-0 Pitt run that turned a close game into a rout, 34-17, with 4:23 to play in the first half.
“That run kind of broke the game loose,” North Carolina A&T coach Jerry Eaves said.
Pitt freshman center DeJuan Blair played only 15 minutes while in foul trouble, finishing with 10 points and seven rebounds. Mike Cook had 13 points and five assists, and Levance Fields added seven points and five assists without a turnover.
Senior guard Steven Rush scored 13 points to lead North Carolina A&T (0-2).
No. 22 Pitt (2-0) will play Rick Majerus-coached Saint Louis (2-0) at 6 tonight for its third game in as many days.
Young’s 3-pointers were some of the biggest baskets of the game.
With Pitt trailing, 12-8, Young hit a 3-pointer from the right wing to start the 16-0 run. He added another 3-pointer during the surge and made a buzzer-beating trey for a 44-23 halftime lead.
“They were leaving me open in transition, and they seemed to lose track of me,” Young said. “I took advantage of it.”
Young was a poor outside shooter his first two seasons at Pitt, going 4 of 21 from 3-point range as a freshman (19.0 percent) and 13 of 42 last season (31.0 percent).
Ninety minutes before tip-off yesterday, he was shooting by himself in a near-empty Petersen Events Center. The effort is paying off.
Young is shooting 69.0 percent (20 of 29) from the field this season.
“His shooting has improved dramatically,” coach Jamie Dixon said. “But he works hard at it. That’s half the battle.”
One night after having its highest-scoring game in 12 seasons, Pitt came out sluggish against North Carolina A&T.
The Aggies led, 9-6, three minutes into the game and went up 12-8 on Ed Jones’ layup with 16:10 to play in the first half.
With 12:30 play in the first half, Pitt still trailed, 14-13.
But Pitt held North Carolina A&T scoreless for a 6:25, and Young scored 15 points over the final 12:27 of the first half. Pitt led by at least 21 the entire second half.
Eaves, a former player and assistant coach at Louisville, believes Young will find scoring a lot tougher once the Big East schedule begins.
“If he continues to hit his perimeter shot, he will be a tough matchup,” Eaves said. “But the Big East is competitive. Teams like Louisville, they have quite a few guys his size and his athletic ability that will be able to guard him out on the floor when he puts it on the floor. I don’t think he’s a huge matchup problem with the better teams in the Big East.”
Eaves, the starting point guard on Louisville’s 1980 national champion, said Fields is the key to Pitt’s success.
“Fields is not a great shooter. But he gets in the gut, and he creates things for them,” Eaves said. “If you have someone who can guard him and stay in front of him without a lot of help, to where people can stay closer to their shooters, I don’t think they are the greatest pure shooters in the country. Just being honest with you.”
Note : Freshman center Gary McGhee, a potential redshirt candidate, played four minutes for his first action of the season. He had no points and one rebound.


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Alana Mendelsohn, MD, PhD
Empowering patients to be active and informed participants in
personalized, evidence-based treatment
Dr. Mendelsohn is a Columbia University trained and affiliated psychiatrist and neuroscientist. She works with adults in both medication management and psychotherapy, with a particular focus on mood and anxiety disorders, obsessive compulsive disorder (OCD), attention deficit disorder (ADD/ADHD) and post-traumatic stress disorder (PTSD).
Her practice strives to take a warm, collaborative, and non-judgmental stance to create individualized treatment plans for each patient, incorporating medication and/or psychotherapy as appropriate. Her treatment approach draws from multiple perspectives in psychiatry, including psychodynamic therapy, cognitive-behavioral therapy, mindfulness and neuroscience.
In addition to her clinical work, Dr. Mendelsohn is a research fellow at Columbia’s Zuckerman Mind Brain Behavior Institute studying the organization of regulatory brain circuits that underly many psychiatric and movement disorders. She also has a longstanding interest in the arts and co-founded a non-profit organization, Creatives Care, aimed at helping artists find affordable mental health care.
41 Central Park West, Unit 1H
New York, NY 10023

domain: health


I have recently bought a Samsung galaxy s3 mini and there is no haptic feedback on my soft buttons or typing a message, there is only a vibration key press on my lock screen. I have tryed going into ...
Just got a Samsung Galaxy S3 mini with Android 4.1.1 factory installed. The phone is not locked to any carrier. My problem is that I can not for the life of me find the setting to turn on the haptic ...


The Turkish pople loved Israel and the Israelies, but we can make do without their friendship, with a prime minister who is trying to attack our dignity and honor. With such friends, who needs enemies. We will do without Israel until the day that they will have a more sensible Prime Minister (+Foreign Minister).
Chief suspect in Bangkok bombing case arrested (dpa)
from the article: Turkey FM condemns Israeli 'plan' to support PKK


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The 2023 MSI and summer events will bring exclusive skin thematics to LoL
After introducing to its fans to the Faerie Court earlier this month, Riot Games is exploring new thematics for League of Legends’ skin lines. In a dev blog released today, Andrei “Meddler” Van Roon, the head of League studios, said that new thematics are coming to the game this year.
Using the Faerie Court skin line as an example, Riot Meddler explained that the devs are always exploring new skin thematics for League, with the next one coming up this May. To celebrate the first international event of the year, Riot will release a creative new skin theme hoping to enthrall MSI fans. In 2021, a Conqueror skin and its Prestige edition were released for the event along with the Worlds 2020 champions’ skins, and last year, the High Noon battle pass and its skins were tied to MSI.
Considering Riot is working on the new thematic in relation to the “large event” that is MSI, League fans might see an esport-related skin line coming soon. Since MSI 2021, Riot has been approaching the event with a modernized style, which can also be seen in the graphics on the broadcast, so it might be that the upcoming skin line related to this year’s MSI will also get the same treatment. But League fans will have to wait just a bit longer to discover what Riot has, and will have, in store for them.
In addition to that, Riot Meddler confirmed the arrival of the summer event for 2023 as well, which will include new skin thematics just like for MSI. The second “large” event mentioned in the dev blog will most likely hit the League client in late June or early July, just in time for the Northern Hemisphere to embrace the warm sun of summer. But if Riot is exploring uncharted territory in the skin department, it’s likely that the Pool Party skins will not be featured in the event since that’s a thematic that was first released over 10 years ago.
Related: Riot reveals which Wild Rift skins will be heading to LoL with a summer release date
Although there is no information about what the theme for the summer event will be, League fans’ expectations will surely match the hype that was created around last year’s Star Guardian event.

domain: game


Ecuador shipbuilder Astinave has selected a warship design developed by Germany’s Fassmer to be utilised on a new class of multi-purpose combat vessels for the Ecuadorian Navy.
The vessels will be used for maritime security patrols, search and rescue (SAR), fisheries and environmental protection, limited cargo transport, and humanitarian and disaster relief (HADR).
Each vessel will also have a helicopter deck and stern-mounted launch equipment for two small interceptor boats.
The best maritime site on the web. The sea's our scene!


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Kochi: Ernakulam South police have brought a 23-year-old suspected Afghan national who was taken into custody in Kolkata, to this city, according to the police. Khan, claiming to be from Assam, has worked in the Cochin Shipyard as a casual worker for more than a year and possesses an Aadhaar card.
His close family members also live in Kochi. After a tiff with his uncle, his Afghan identity was revealed. Khan’s mother, though an Assamese, lives in Afghanistan now. By the time the police intervened and discovered that Khan had acquired an Aadhar card using fake documents, the suspect had already fled Kerala.
Later, police tracked him to Kolkata, and a team of officers from this city went there and arrested him. ‘Our officers have brought him from there, and the investigation has begun. He is currently in judicial custody,’ said a police official assigned to the South Police Station.


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SP Connect Diamond Case Set | Bike storage Solution compatible with GoPro Mounts
HERO GEAR now sells SP Gadgets | SP CONNECT accessories for Bike, Phone, Car, Fitness and Storage
All Australian Stock and Warranty - Free Standard postage Australia Wide included in the Price
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The SP ConnectTM DIAMOND CASE offers protective and weatherproof storage for your biking essentials, e.g. spare tube, tools, etc. The case can be easily attached to or removed from the included CLAMP MOUNT with it’s patented twist to lock mechanism. The case features MicroRails which allow you to attach the SP ConnectTM All-Round Safety Light (not included) directly on to the case.
- Quick and secure attachment - Simply turn 90 degrees for secure lock
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- Compatible with other SP Connect system accessories
12 Months Australian Warranty
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domain: hobby


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The Los Angeles Lakers have been aggressive looking to improve before next season with Kyle Kuzma and Kentavious Caldwell-Pope reportedly often used as trade bait.
"They have literally offered Kyle Kuzma and KCP to almost every team I’ve talked to in the league," ESPN's Adrian Wojnarowski said Sunday on the Woj & Lowe Free Agency Special.
Wojnarowski added most teams have received offers for some combination of either one player or both of them this offseason.
Outside of LeBron James and Anthony Davis, Caldwell-Pope ($13.04 million) and Kuzma ($13 million) have the highest cap figures on the team for 2021-22, per Spotrac. Marc Gasol ($2.69 million) is the only other player with a guaranteed contract, while Montrezl Harrell has a $9.7 million player option.
Clearing the salary-cap space could allow the Lakers to add another impact player in free agency—Shams Charania of The Athletic reported they are interested in Kyle Lowry—or re-sign their current free agents, such as Dennis Schroder and Talen Horton-Tucker (RFA).

domain: sports


MIAMI, Fla. (Ivanhoe Newswire) -- Whether it is from an unexpected virus sweeping across the world, or losing a battle against a long-term illness, most of us have felt the pain of losing someone. But how you deal with the pain could impact you and your children for the rest of your lives.
“Sarah was everything I wanted in a partner. She found the tumor when she was eight months pregnant,” said Sergio Mendoza, now a widower and single father. He lost his wife three years ago. His sister died from cancer a year later. “I think it’s a lot to handle for a lifetime,” stated Mendoza.
Both Sergio and his son found comfort at the Children’s Bereavement Center. “You just really want to try it and make your child feel as normal and as comfortable as possible,” said Mendoza.
Psychologist Mindy Cassel co-founded C.B.C. 21 years ago. “The impact of loss is very individual. Being with others who have a loss is being with people who get it,” said Mindy.
That’s what helped Jess Tafel. “My dad was my best friend,” said Tafel. “He was building a tree house for the kids. He drilled a screw through his thumb. His lungs shut down, and it was through a staph infection probably caused by the wound,” said Monique Selman.
Initially, it was the free pizza that lured, then 11-year-old Jess, to C.B.C. but something else kept her coming back. “It was a great place to be with people my own age who are going for the same things. Whereas in places like school, it was very obvious that people were uncomfortable,” said Tafel.
The sessions are held in schools for kids as young as five, teens, adults, and caregivers. “Research shows that group support is the most important factor in someone having healthy grief,” said Chira Cassel, MAPP, CT, and CEO of the Children’s Bereavement Center. “Every day we meet someone who, it’s their worst day but every day we also see people get stronger. Start loving themselves more,” said Chira.
They say don’t try to shield your child from the truth. “You give it to them early on before somebody else does,” said Mindy. And you don’t have to get over it or move on. “That person can continue to inspire them. Loss is a part of life and knowing that we can survive it, but not only survive it, we can thrive after, and that makes a big difference,” said Mindy.
“I didn't have to be sad all the time, that I could have a happy life,” said Tafel. Healing yourself and helping others heal as well.
The groups are free and open to anyone. There are now ten centers, including the latest one in Parkland, Florida, where the mass school shooting claimed the lives of 17 people. C.B.C. also provides seminars throughout the country. Since its inception, the Children’s Bereavement Center has trained more than ten thousand professionals in helping others deal with grief.
It costs two million dollars to run the C.B.C. All of it is raised through donations. You can find out more and get online tools to deal with grief at www.childbereavement.org


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Let the Good Times Roll
We hear music in the distance, a linger of laughter and the sweet scent of good food. The holiday season is rolling around and it’s getting hot in here! Pick up your friends, ‘cause we are going on the ride of a lifetime filled with dancing, unimaginable fun and endless laughter. Who’s in?
Shall We Dance?
May the party get started and you find yourself dancing all night long. But don’t stop during the day. Whether you find yourself dancing in that new fit you’re feeling, your tongue dances to the taste of some new flavours, or your feet find some new moves on the d-floor, there is a dance for everyone on every occasion. Get up and get grooving, it’s about time we got moving.
Your Go - To Guide to NNSW
If you’re like us and in long overdue interstate travel escape, look no further than our friendly neighbors in northern New South Wales. With the current travel situation and scorching hot climate, we consider ourselves pretty damn lucky to be living down the road from one of the country’s best (not so hidden) gems. NNSW has a magical blend of luxurious locations, creative crowds and breath-taking beaches that we can’t wait for you to experience. We guarantee you’ll be feeling rejuvenated and refreshed whether you stay for a weekend or a whole week.
Eat, stay and play in NNSW!
Northern New South Wales has a whole lot to offer. Take a road trip and indulge in all this beautiful part of the world has on show. Visit for the day or stay a while!
Home is where the insta-heart is
Needing a refresh in your humble abode? Have a certain aesthetic? Just a huge window shopper? Instagram’s got you covered, here’s ten home accounts.
JUST A SHORT FLIGHT OR DRIVE AWAY
With the end of summer quickly creeping up on is, why not squeeze in one last quick little summer getaway! With something for everyone, we have curated a list of 5 hot summer holiday destinations that are only a quick flight or drive away. The best holiday souvenir is a suntan and smile from the goods times...
10 Date Ideas That Are The Perfect Foreplay
Noosa, my fair friends, is the pièce de résistance of the Sunshine Coast. With its breathtaking ocean views, its indulgent and delectable assemblage of restaurants, and its abundance of retail therapy, Noosa is, by and large, a delight for the soul. This Summer, when the temperature climbs and you seek a little piece of paradise, pack the car, take your partner by the hand, and get yourselves ready for cheeky little trip northbound. It’s time to get Naughty in Noosa!
Slay Your Career Goals
Become the ultimate #GirlBoss. In celebration of International Women's Day this month, here are some tips from CEO Kate Middleton.
An uplifting festival celebrating the achievements of women and girls
The Queensland Premier in London has announced Queensland will host the first ever Women of the World (WOW) in tandem with the Commonwealth Games 2018. #WOW
Kooza Comes to Brisbane
DARE-DAZZLING, dramatic, DEATH-DEFYING, heart-stopping, utterly brilliant …. KOOZA by Cirque du Soleil is in town for 2016. The name KOOZA is inspired by the Sanskrit word “koza,” which means “box,” “chest” or “treasure,” and was chosen because one of the underlying concepts of the production is the idea of a “circus in a box.”
Ticket for the Brisbane season of KOOZA are at Cirque du Soleil Kooza website or by phone on toll free 1800 036 685. Showing at Skygate (next to Brisbane Airport DFO) from Nov 24 2016 until Jan 8 2017.
Fashion, Fun, Bars & Sun
This week there is lots to look forward to in Brisbane with the opening of a new rooftop bar, the continuation of the Italian Film Festival, a new bar in Petrie Terrace, a fav beauty bar spreads wings and much more. So get behind our city and support the local events and business because remember, local is lovely!

domain: geography


text:
The room is filled with overpowering vanilla - the scent hangs everywhere like a huge, ominous cloud. There is a bed, positioned in the exact centre of the small white room. All the walls are white, a clear spotless white, with a few windows and no lights or other furniture. The bed, too, is white, silk sheets and silk pillow and silk blankets. There is no colour in the room. Even the vanilla smell is white and empty. On the bed, a young boy sits. His hair is long and dark, flowing down his back; his skin is the same white as the room. His eyes stare out of a thin face, dark grey and almond shaped. His cheekbones are too high, making his face unnatural, not ugly, but certainly not pretty, hard to look at for the oddities, and expressionless, uncaring. His lashes are long, like a woman's, and print on the cheekbones. He is far too thin, and his hands and feet too small. There is a feel of "too" around him - everything about him is too something. His clothes are white as well, just like the room, like everything else. A soft white linen tunic belted with white satin, and ivory leggings. His white feet are bare, his head uncovered. He looks stark, and unwrapped, and the darks of his hair and eyes and lashes conflict and collide and clamour against the whiteness of his world.
He sits, unseeing, staring at nothing through one of the windows, a window that overlooks the sea. A tremendous, never-ending ocean, cascading into the distance, ebbing and flowing in an eternalness. Whitecaps grace the waves, and the sun cuts down through white clouds, turning the entire surface into a lake of molten silver.
A few tears escape his blank eyes, catching in his lashes and glittering in perfectly held drops of rainbow salt water. His hands twitch, folding and unfolding, his lips suddenly moving in a silent prayer, or song, or lost longing.
The door to the room is opened unexpectedly, but he does not flinch or even show that he has noticed. A young woman steps in, clothed in a dress that sings and flaunts its colour: Rich silks in purple and crimson and dark clear blue that has never been navy, the skirt billowing out. The sleeves are wide and flowing, and she wears a tiara of some blue stone on her pouring golden hair. She counters the boy in every aspect, wildly beautiful, with clever green eyes and a full mouth turned up in a smile. She carefully does not move even a dainty slippered toe over the line separating the white, thin carpet within the room and thick, fluffy, emerald one outside. In a voice that lilts sweetly, she asks:
"Musouka, it's Lelyi. Would you like to come out and play?"
He turns to look at her then, throat convulsing at the sight, and whispers, "Never. Leave me alone. Go away. I want my books."
She frowns gently, in a concern that carries a bordering touch which slyly hints she is humouring him, but that at the same times struggles to prove honesty in her emotion. "Would you like to eat?"
"I shan't eat. Go away."
"Musouka, lovey, everyone wants to see you."
"I'm not a pet. I want my books back. I hate you." He speaks softly, but with a childish protestation, his voice straining at the words. "I need my books. I don't want to be your child. I don't want to be your puppy. Go away. Let me out of here forever, let me go home."
"Oh, darling, this is your home. The marble house by the sea. You'd love it here, if you'd only come out for a while and look around. Cousin Silio does so want to meet you."
"He wants to look at me, and touch my hair because it's black, and everyone here has awful gold, and wonder over my skin because everyone else is pale gold, and then ask me what I dream about like all the people here do because they don't dream, and pity me for what I am. I shan't come out. I shan't leave my bed. Go away."
She sighs dramatically, as if trying to pull him off the white silk sheets and into the brilliantly coloured hallway. "Musouka, won't you at least call me by my name? How much do you hate me? How long will you stay in there?"
"Until I die, or until someone lets me go home."
She sighs again, and turns from the room, closing the door. On her side of the hall, it is painted dark gold. She looks at the old woman who stands beside her, before concealed by it. This woman shrugs bony shoulders, and squints at Lelyi with dimmed green eyes, pushing her wispy, once-gold hair out of her face.
"Nothin' y'can do. Silly hybrids. Forget it - s'tea time, anyhow."
"Calia, he was one of their princes. Before our houses took over. There used to be huge clans of them, the hybrids, and now they're mostly all dead. So Fe of course brings home one of their children, and hopes he'll like living here with us. He would have been happier to die with his parents. I think he had a sister. I feel evil. I feel as though we should let them all go, and leave their world. He never leaves the room, he wanted it all in white, and that's mourning. He's a Felakese hybrid too - only saying hybrid seems so disrespectful - so he fasts, and he never wears colours. He hurts, can't you feel the ache that bursts out every time I open the door? We shouldn't keep him. We should let him go."
"Silly girl, just as them. You think he could survive on his own? It'll please him no end to die here, wasting away. He'll feel good and martyred, and it'll thrill him. Forget it, like I said. Come on and eat."
Lelyi sighs a last time, making herself a note to bring the hybrid prince more vanilla next time she tries to bring him out, and follows the woman down the gold-and-green hallway into one of beautiful blues and silvers, ripping in spiralling, rolling, waves and ribbons over the walls, down a wide marble and gold swirled staircase, then onto a veranda of soapstone with long mahogany tables. The other Jelasin angels are already there, in a frantic flourish of colours and materials and patterns, all talking among themselves. Lelyi takes her seat with the old woman, tucking an embroidered silk napkin into her lap.
A tall, violently handsome young man resplendent in wine-coloured velvet stands and calls over to her, his voice clear and ringing so that she flinches.
"Hey, Lelyi, have you wormed your hybrid out of his hole yet?"
Blushing, she tells him not yet, wishing she knew his words wouldn't carry to Musouka's room. But she knows they will, and she feel her heart sink.
On his bed, Musouka grits his teeth and falls face down on the bed, losing his statue nature, sobbing into the pillow, hot tears spilling onto the cool silk. Another day, he knows. Just another day. Some day, it will all end.
He's praying that day is soon.
/Pearls swim in the wide salt seas, turning
And singing in the waves
Moonstone dances through moonlight
Sapphire twists into fresh free skies
Rubies trickle through
And emeralds caress burning skin/
/And my captive, my captive
My little captive soul
Looks out the only window
And imagines grasses, long and tall and velvet
Swishing against bare knees.
Imagines droplets of sunset
Caught in the clouds
Imagines the wild blue waters of a great lake
And pale, white-bellied fish
The soft reeds and softer, silken sand
Round moons somewhere far away and very high up
In the starry sky/
/And sharp spruce means nothing
As crystal glows…/
/And a quiet, lonely song plays over the fields of tall,
And the melody is covered with dust, fine grey dust
It blows in the wind,
Spreading wings of prayer/
/And the captive waits. The captive
Someday the prison doors will open
The sunset won't have bars across it
And the world won't be blurred
For there will be no longer tears in my eyes/
/But while the day waits, and pauses
And lingers in its course
Until joyfully the doors spring open
And the world belongs
/The little captive spirit mourns
And the little captive heart grows too full
And captive tears flow down,
But do not fall free
Bound fingers cannot take your hand
And parched lips cannot kiss your mouth/
/Someday the loneliness will end
But till then
I'll be a captive…
Owari ~ End

domain: artistic


text:
Everyday Use by Alice WalkerAlice Walkers early story, Everyday Use, has remained a cornerstone of her work. Her use of quilting as a metaphor for the creative legacy that African Americans inherited from their maternal ancestors changed the way we define art, womens culture, and African American lives. By putting African American womens voices at the center of the narrative for the first time, Everyday Use anticipated the focus of an entire generation of black women writers.
This casebook includes an introduction by the editor, a chronology of Walkers life, an authoritative text of Everyday Use and of In Search of Our Mothers Gardens, an interview with Walker, six critical essays, and a bibliography. The contributors are Charlotte Pierce-Baker, Houston A. Baker, Jr., Thadious M. Davis, Margot Anne Kelley, John OBrien, Elaine Showalter, and Mary Helen Washington.
I will wait for her in the yard that Maggie and I made so clean and wavy yesterday afternoon. A yard like this is more comfortable than most people know. It is not just a yard. It is like an extended living room. When the hard clay is swept clean as a floor and the fine sand around the edges lined with tiny, irregular grooves, anyone can come and sit and look up into the elm tree and wait for the breezes that never come inside the house.
But she has written numerous other novels, stories, poems, and essays. They are nervously waiting for a visit from Maggie's sister Dee, to whom life has always come easy. Dee announces that she has changed her name to Wangero Leewanika Kemanjo, saying that she couldn't stand to use a name from oppressors. This decision hurts her mother, who named her after a lineage of family members. During the visit, Dee lays claim to certain family heirlooms, such as the top and dasher of a butter churn, whittled by relatives. But unlike Maggie, who uses the butter churn to make butter, Dee wants to treat them like antiques or artwork.
It was first published in as part of Walker's short story collection In Love and Trouble. The short story is told in first person by "Mama", an African-American woman living in the Deep South with one of her two daughters., You know, because it's got love… and trouble, trouble, trouble. Walker published this collection of stories in , exactly a decade before she won the Pulitzer Prize for a little book you might've heard of called The Color Purple.
On a deeper level, Alice Walker is exploring the concept of heritage as it applies to African-Americans. This was a time when African-Americans were struggling to define their personal identities in cultural terms. She uses the principal characters of Mama, Dee Wangero , and Maggie to clarify this theme. Mama narrates the story. In the winter I wear flannel nightgowns to bed and overalls during the day. This description, along with her reference to a 2nd grade education , leads the reader to conclude that this woman takes pride in the practical aspects of her nature and that she has not spent a great deal of time contemplating abstract concepts such as heritage. However, her lack of education and refinement does not prevent her from having an inherent understanding of heritage based on her love and respect for those who came before her.
Mama fantasizes about reunion scenes on television programs in which a successful daughter embraces the parents who have made her success possible. Whereas Mama is sheepish about the thought of looking a white man in the eye, Dee is more assertive. Mama remembers the house fire that happened more than a decade ago, when she carried Maggie, badly burned, out of the house. Dee watched the flames engulf the house she despised. Back then, Mama believed that Dee hated Maggie, until Mama and the community raised enough money to send Dee to school in Augusta.

domain: library


text:
Capturing Voices of Migrants in Cities
This audio-visual exhibition is designed to raise awareness on the importance of spatial planning for migrant* inclusion in cities, reducing xenophobia by introducing migrants and their personal stories and underlining the role of local actors and decision-makers for social cohesion and inclusion.
*Note: For this project, the term “migrants” is used for all people on the move, including refugees, IDPs, returnees, seasonal workers, migrants (rural-urban, but also between cities)
Photographs and audio will be collected in an open call for submissions from 20 November 2019 until 10 January 2020.
The exhibition will be launched at the World Urban Forum (WUF 10) in Abu Dhabi, in February 2020.
The audio-visual exhibition will:
• Introduce migrants, with a strong focus on children, youth and women in their favourite spaces in their city of arrival. In the audio contributions, which will be available on a website and accessible via a QR code, they will tell their stories and share what spatial aspects made them feel safe and welcome and who (or what institution) played a major role for in providing information and supporting their arrival.
• Allow migrants to share their hopes and aspirations, their challenges and their personal (positive or negative) experiences in daily (urban) life and introduce spectators to migrants’ realities.
• Raise awareness that migrants are individuals and reinforcing the fact that migrants and refugees have “the right to the city”.
• Focus on migrant children, youth and women, as they are often being left behind and their (special) needs are often not considered for city development, service provision and urban planning.
• Reflect diversity of migrants in social, educational and economic background by not only showing migrants or refugees as a group of people in a vulnerable situation but introducing a broad range of life stories.
• Showcase the“spatial dimension of inclusion” and highlight the importance of inclusive (public) spaces enabling social cohesion.
• Highlight the role of local stakeholders in providing services and support structures. In their stories, migrant children, youth and women will explain what the most enabling factors were (including institutionalized or civil society actors who support structures for their settling in).
The exhibition aims to contribute to changing the narrative on migrants and reduce xenophobia, thus supporting the implementation of the Global Compact on Migration and the Global Compact for Refugees. Through its emphasis on “spatial factors” for human well being and by underlining the role of local players, it creates a link to the New Urban Agenda and enhances the understanding that safe and inclusive cities are needed for achieving the Sustainable Development Goals (SDGs).
For the exhibition at the WUF, a selection of photos will be printed at large-scale. Audio recordings and other photos will be made available on the accompanying website and used for social media campaigns.
Photographs and audio will be collected in an open call for submissions from 20 November 2019 until 10 January 2020. Submissions can be uploaded to a Flickr-page (www.flickr.com/groups/migrantsincities/) after accepting the group rules.
Audio files can be shared with the UN-Habitat project team (firstname.lastname@example.org).
If you would like to submit audio files, please contact the team for further instructions and a set of questions.
This exhibition call is a collaboration between UN-Habitat, UCLG, UNICEF & Mayors Migration Council.

domain: sociology


text:
The FBI Director's Evidence Against Encryption Is Pathetic
Froomkin, Dan; Vargas-Cooper, Natashahttp://firstlook.org/theintercept/2014/10/17/draft-two-cases-cited-fbi-dude-dumb-dumb/
Date Written: 2014-10-17
Publisher: The Intercept
Year Published: 2014
Resource Type: Article
Cx Number: CX16835
FBI Director James Comey gave a speech Thursday about how cell-phone encryption could lead law enforcement to a “very dark place” where it “misses out” on crucial evidence to nail criminals. To make his case, he cited four real-life examples — examples that would be laughable if they weren’t so tragic.

domain: law


KUCHING: Many corporate social responsibility (CSR) programmes carried out by Sarawak Information System Sdn Bhd (Sains) can be adapted by the state government in line with the go-rural policy, said Chief Minister Datuk Patinggi Tan Sri Adenan Satem.
He mentioned the rural ICT guided home-based technopreneuer (RIGHT), community healthcare advancement nurturing for growth eco-system (CHANGE), equitable quality unified information via Learning in a Box for Rural Areas or Library in a Box as among the relevant programmes.
“I have a concern and deep commitment to bridge the digital bridge between urban and rural areas and bring modernity to rural areas. Recently I have instituted a policy to go rural and set key performance indicators (KPIs) for the state elected representatives to gauge their involvements with their respective constituents.
“And I can immediately see the relevancy of many current Sains CSR programmes which can be adapted for this purpose,” he said at Sains 25th anniversary dinner at Borneo Convention Centre Kuching (BCCK) on Wednesday night.
Adenan was represented by Deputy Chief Minister Datuk Amar Douglas Uggah Embas).
In his text of speech read by Uggah, the chief minister hoped that Sains would work closely with the state government to explore how to optimise such area of collaboration.
Adenan also pointed out that he was proud and happy with what SAINS had achieved for the state and itself for the last 25 years, saying it had propelled the utilisation of information and communication technology (ICT) of the state government from being the lowest to currently among the highest in the country.
According to him, such effort had enabled and re-defined the civil service delivery’s efficiency and effectiveness, adding that Sains was also constantly transforming itself to become one of the leading and most admired ICT solutions and services providers in the country.
Adenan also said the launching of Sains’ ‘Infocast Kenyalang (IK) or I care about Sarawak’ had helped the people, especially in rural area, to know and understand the government’s real development agenda against the trivialities of the opposition.
“I urge all government agencies to work closely with Sains to inform the people of the good work being done to them. Now that we have won the last state election with a much increased majority, it is very important for us to deliver our promises and be seen by doing so,” he stressed.
He pointed out that the government must be acutely aware about the performance, stressing that the performance was being closely watched by the opposition and the people at large.
Meanwhile, Adenan was also happy to note that Sains, apart from providing ICT products and services in Peninsular Malaysia, had also penetrated foreign countries like New Zealand, Australia, Papua New Guinea, Philippines, Brunei, Myanmar, China, Qatar and Guinea.
The dinner also the presentation of several awards including the Chief Minister’s ICT Media Awards by Uggah.
The award in three categories- English, Bahasa Malaysia and Mandarin – was established to encourage journalists and writers to address ICT related topics and promote the usage of ICT and awareness of its importance for the betterment of Sarawak.
Winners of the award received RM2,000, while the first and second runners-up received RM1,000 and RM500 respectively.
For the English category, The Borneo Post won all the three prizes with Sharon Kong the first prize winner, followed by Yvonne Tuah Merawin (first runner-up) and Joanna Yap (second runner-up).
In the Bahasa Malaysia category, Haini Darani of Utusan Sarawak won the first prize, followed by Remid Tajan of Rakan Sarawak and Muhammad Fuad Jobli also from Rakan Sarawak.
For the Chinese category, the first place was won by Jong Wan Joon from Sin Chew Daily with Chieng Jen Ling and Liong Chai Ee (also from Sin Chew Daily) in second and third places respectively.
Present were Sains chairman Datuk Patinggi Tan Sri Dr George Chan and Sains chief executive officer Dato Teo Tien Hiong.


According to a new report, Apple’s mini-LED suppliers for its 12.9-inch iPad Pro have for its redesigned 14-inch and 16-inch MacBook Pro models featuring flat edge-to-edge design, no touch bar, fingerprint sensor, powered by next-generation Apple Silicon, M1x chip built on 5nm+ process. The updated machines are slated to launch in quarter 3 2021.
Apple mini-LED suppliers preparing for 14-inch and 16-inch MacBook Pro launch in September
According to the report, Zhen Ding Technology and Tripod Technology will be gearing up in the third quarter of 2021 to meet the demand for 14-inch and 16-inch MacBook Pro models, which are “set for launch in late third-quarter 2021,” sources told DigiTimes.
Zhen Ding Technology and Tripod Technology have both entered the supply chain for Apple’s upcoming mini LED-backlit MacBook series, and will be ramping up their shipments of backlight boards starting the third quarter, according to industry sources.
Tripod has reportedly cleaned Apple’s validations for equipment and capacity at its new plant in China’s Xiantao, Hubei province, and will be able to begin production of mini-LED backlight boards for the redesigned MacBook Pro sources in the third quarter. As for Zhen Ding, the company will complete its second-phase investment in capacity expansion for such boards in the third quarter.
The third quarter runs from July through September, so Apple could announce the redesigned MacBook Pro models during or around its annual iPhone event, which will return to its September schedule this year. Keeping in mind the recent disruptions the tech giant has faced due to the ongoing global health crisis, a September MacBook Pro announcement is not out of the question.
The highly anticipated redesigned MacBook Pro models will feature the most significant design update users have seen since 2016. The 14-inch model will replace the current 13-inch variant whereas the 16-inch model will be a counterpart to the existing 16-inch Macbook Pro model.
Industry sources claim the new models will have a flat-edged design similar to iPhone 12. The updated machines could also address several complaints users have had with the lineup for years by including MagSafe charging, replacing Touch Bar with physical keys, and featuring an HDMI port and SD card reader. As is customary with updated MacBook models, users can expect enhanced performance and improved battery life.


text:
This week’s “Fabulous Friday Finds” are affordable elegant handmade Journals for the person who wants something unique and dazzling! And as a follower of THOUGHTS on THIS ‘n THAT, you get a special 10% discount, if you order any from JOURNALU and type in THISNTHAT10 in the coupon section.
I thought hilighting Kristen’s one of a kind journals would be perfect for followers of THOUGHTS on THIS ‘n THAT. If you belong to our blog, you have a special place in your heart for the written word. Whether you’re an author, would-be author or you love reading, journaling is probably part of your life. It has been mine for a while. I love to write, doodle, collect things – my journaling is kind of like “assemblage.”
A LITTLE BIT ABOUT KRISTEN
KRISTEN has been journaling since she was 5 years old, although back then it was called keeping a diary [that was 33 years ago]. She had a Holly Hobbie diary with the gilt-edged pages and lock and key. She wrote about what she had for dinner and what she did that day and locked it up and hid it so her brother wouldn’t read it. This was secret stuff! She kept diaries until high school when it progressed to being called journaling, and she filled simple composition books with her teen angst. Soon she found that there was a world of beautiful journals just waiting for her words, and she filled them almost as quickly, as she could buy them.
What started at such a young age as just a simple itch to put pen to paper slowly grew into a process that soothes her soul. She writes about anything and everything wherever and whenever the mood strikes. Anything on her mind at the time, she sits down to write is fair game for her journal. It keeps all of her secrets.
They’re handmade sewn bound notebooks using decorative paper, embellishments, distressed ink stains, brads, clips, decorative lettering and all kinds of one of a kind details!
Here’s the best part: The journals start at $20, she takes all credit cards and you get a 10%-discount by being a follower of THOUGHTS on THIS ‘n THAT!
Just go to the ETSY site, choose a journal and when you check out, type THISNTHAT10 in the coupon area JOURNALU
Time is winding down, but you still have time to order and get your journal before Christmas – hopefully! If you’re not in a hurry, she makes them to order – uniquely yours!
FYI: We’re giving away one of Kristen’s fabulously designed journals. Just tell us one secret you would put in your new journal.


text:
Vintage Baseball Personalized Wall Hanging by Dish and Spoon Productions
Ready! Set! Play Ball! Inspire your little slugger to celebrate America's favorite pastime with the "Vintage Baseball" custom canvas wall hanging! An original design by children's fine artist Stacey Harnisch, this delightfully detailed painting has been reproduced onto museum-archival-quality canvas using the giclee method of fine art printing. Each edition measures 2ft.x3ft. and is trimmed by hand to bring to life the detailed edges of the canvas. The "Vintage Baseball" wall hanging is available in Home Run Blue or may be ordered with a custom color of your choosing. For an extra special keepsake, personalize the canvas with your child's name (e.g., L-Lawson), the standard text (i.e., Little Slugger), or your own favorite phrase. Please specify your color and personalization preferences when ordering. To preserve the integrity of the artwork for years to come, the surface of the canvas is glazed with a UV protective finish. The canvas arrives ready to hang with a wooden dowel, finials, and decorative color-coordinated ribbon or optional hand-painted wooden topper. The topper adds approximately 3 inches to the height of the canvas. Hand-crafted and custom-made in the USA, the "Vintage Baseball” wall hanging is the perfect decorative statement for a boy's bedroom or play area! Pair with additional wall art from the "Vintage Sports Collection" for a group display!
Stacey Harnisch began her love affair with the arts early on. "I've been interested in art from the time I was able to pick up a pencil," Stacey recalls. "As a child, I loved looking at the detail in story book illustrations. I focused on that detail and learned to emphasize it in my own artwork. I also had a wonderful elementary school teacher who encouraged my talent, laying the foundation for my love of art." Stacey has a Bachelor's Degree in Art from Nebraska Wesleyan University. Today she uses her artistic abilities to create unique custom artwork in the form of whimsical wall murals and original paintings through her company, Little Boy Blue and Ella Too. "I love creating magical spaces for children," she says. "Places where children can dream and let their imaginations soar! I feel truly honored that my paintings have become such a special part of so many children's rooms!" Stacey currently resides in Fort Collins, Colorado, with her husband and two children. Her classic designs are offered exclusively on Dish and Spoon Productions' award-winning wall art!
SIZE: 2' x 3'
Category: Art, Complete Baseball Boys Room Collection
|Other Items In This Collection|


text:
Oxidative stress is proposed as an important factor in osteoarthritis (OA). We therefore investigated the expression of the three superoxide dismutase (SOD) antioxidant enzymes in OA.
SOD expression was determined by real-time polymerase chain reaction and immunohistochemistry using human femoral head cartilage. SOD2 expression in Dunkin Hartley guinea pig knee articular cartilage was determined by immunohistochemistry. The DNA methylation status of the SOD2 promoter was determined using bisulfite sequencing. RNA interference was used to determine the consequence of SOD2 depletion on the levels of reactive oxygen species (ROS) using MitoSOX™ and collagenases, matrix metalloproteinase 1 (MMP-1) and MMP-13, gene expression.
All three SOD were abundantly expressed in human cartilage but were markedly down-regulated in end-stage OA cartilage, especially SOD2. In the Dunkin Hartley guinea pig spontaneous OA model SOD2 expression was decreased in the medial tibial chondyle cartilage prior to, and following, the development of OA-like lesions. The SOD2 promoter had significant DNA methylation alterations in OA cartilage. Depletion of SOD2 in chondrocytes gave an increase in ROS but a decrease in collagenase expression.
This is the first comprehensive expression profile of all SOD genes in cartilage and importantly, using an animal model, we show that a reduction in SOD2 is associated with the earliest stages of OA. We found that a decrease in SOD2 associates with an increase in ROS and but a reduction of collagenase gene expression, demonstrating the complexities of ROS function.
Osteoarthritis; chondrocytes; superoxide dismutase; gene expression
Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in the elderly. It is characterized by changes in joint structure including degeneration of the articular cartilage and its etiology is multifactorial with a strong postulated genetic component. We performed a meta-analysis of four genome-wide association (GWA) studies of 2,371 knee OA cases and 35,909 controls in Caucasian populations. Replication of the top hits was attempted with data from additional ten replication datasets. With a cumulative sample size of 6,709 cases and 44,439 controls, we identified one genome-wide significant locus on chromosome 7q22 for knee OA (rs4730250, p-value=9.2×10−9), thereby confirming its role as a susceptibility locus for OA. The associated signal is located within a large (500kb) linkage disequilibrium (LD) block that contains six genes; PRKAR2B (protein kinase, cAMP-dependent, regulatory, type II, beta), HPB1 (HMG-box transcription factor 1), COG5 (component of oligomeric golgi complex 5), GPR22 (G protein-coupled receptor 22), DUS4L (dihydrouridine synthase 4-like), and BCAP29 (the B-cell receptor-associated protein 29). Gene expression analyses of the (six) genes in primary cells derived from different joint tissues confirmed expression of all the genes in the joint environment.
Imputation is an extremely valuable tool in conducting and synthesising genome-wide association studies (GWASs). Directly typed SNP quality control (QC) is thought to affect imputation quality. It is, therefore, common practise to use quality-controlled (QCed) data as an input for imputing genotypes. This study aims to determine the effect of commonly applied QC steps on imputation outcomes. We performed several iterations of imputing SNPs across chromosome 22 in a dataset consisting of 3177 samples with Illumina 610k (Illumina, San Diego, CA, USA) GWAS data, applying different QC steps each time. The imputed genotypes were compared with the directly typed genotypes. In addition, we investigated the correlation between alternatively QCed data. We also applied a series of post-imputation QC steps balancing elimination of poorly imputed SNPs and information loss. We found that the difference between the unQCed data and the fully QCed data on imputation outcome was minimal. Our study shows that imputation of common variants is generally very accurate and robust to GWAS QC, which is not a major factor affecting imputation outcome. A minority of common-frequency SNPs with particular properties cannot be accurately imputed regardless of QC stringency. These findings may not generalise to the imputation of low frequency and rare variants.
genome-wide association study; imputation; quality control; single nucleotide polymorphism
We have developed a mouse in which the Cre recombinase gene has been targeted to exon 1 of the matrilin-1 gene (Matn1) to investigate the origins of articular chondrocytes and the development of the knee joint. Analysis of joints from offspring of Matn1-Cre/R26R crosses demonstrates that articular chondrocytes are derived from cells that have never expressed matrilin-1, whereas the remainder of the chondrocytes in the cartilage anlagen express matrilin-1. A band of chondrocytes adjacent to the developing interzone in the E13.5 day knee joint becomes apparent because these chondrocytes do not turn on expression of matrilin-1 along with all the other chondrocytes of the anlagen. Articular chondrocytes therefore appear to arise directly from a subpopulation of early chondrocytes that do not activate matrilin-1 expression rather than by redifferentiation from the flattened cells of the interzone. In addition, lineage tracing using both Matn1-Cre/R26R and Col2a1-Cre/R26R lines indicate that non-cartilaginous structures in the knee such as cruciate ligament, synovium and some blood vessels are formed by cells derived from the early chondrocytes of the anlagen.
articular chondrocytes; matrilin-1; collagen II; linage tracing; cre recombinase; joint development; knee development
The knee joint consists of multiple interacting tissues that are prone to injury- and disease-related degeneration. Although much is known about the structure and function of the knee’s constituent tissues, relatively little is known about their cellular origin and the mechanisms governing their segregation. To investigate the origin and segregation of knee tissues in vivo we performed lineage tracing using a Col2a1-Cre/R26R mouse model system and compared the data obtained with actual Col2a1 expression. These studies demonstrated that at E13.5 the interzone at the presumptive joint site forms when cells within the Col2a1-expressing anlagen cease expression of Col2a1 and not through cellular invasion into the anlagen. Later in development these interzone cells form the cruciate ligament and inner medial meniscus of the knee. At E14.5, after interzone formation, cells that had never expressed Col2a1 appeared in the joint and formed the lateral meniscus. Furthermore, cells with a Col2a1-positive expression history combined with the negative cells to form the medial meniscus. The invading cells started to express Col2a1 1 week after birth, resulting in all cells within the meniscus synthesizing collagen II. These findings support a model of knee development in which cells present in the original anlagen combine with invading cells in the formation of this complex joint.
Col2a1; joint formation; knee; lineage tracing; meniscus
Matrix Gla protein (MGP) is a 14-kD extracellular matrix protein of the mineral-binding Gla protein family. Studies of MGP-deficient mice suggest that MGP is an inhibitor of extracellular matrix calcification in arteries and the epiphyseal growth plate. In the mammalian growth plate, MGP is expressed by proliferative and late hypertrophic chondrocytes, but not by the intervening chondrocytes. To investigate the functional significance of this biphasic expression pattern, we used the ATDC5 mouse chondrogenic cell line. We found that after induction of the cell line with insulin, the differentiating chondrocytes express MGP in a stage-specific biphasic manner as in vivo. Treatment of the ATDC5 cultures with MGP antiserum during the proliferative phase leads to their apoptosis before maturation, whereas treatment during the hypertrophic phase has no effect on chondrocyte viability or mineralization. After stable transfection of ATDC5 cells with inducible sense or antisense MGP cDNA constructs, we found that overexpression of MGP in maturing chondrocytes and underexpression of MGP in proliferative and hypertrophic chondrocytes induced apoptosis. However, overexpression of MGP during the hypertrophic phase has no effect on chondrocyte viability, but it does reduce mineralization. This work suggests that coordinated levels of MGP are required for chondrocyte differentiation and matrix mineralization.
endochondral ossification; matrix Gla protein; ATDC5; chondrocytes; apoptosis
Osteoarthritis (OA) has a complex aetiology with a strong genetic component. Genome-wide association studies implicate several nuclear genes in the aetiology, but a major component of the heritability has yet to be defined at the molecular level. Initial studies implicate maternally inherited variants of mitochondrial DNA (mtDNA) in subgroups of patients with OA based on gender and specific joint involvement, but these findings have not been replicated.
The authors studied 138 maternally inherited mtDNA variants genotyped in a two cohort genetic association study across a total of 7393 OA cases from the arcOGEN consortium and 5122 controls genotyped in the Wellcome Trust Case Control consortium 2 study.
Following data quality control we examined 48 mtDNA variants that were common in cohort 1 and cohort 2, and found no association with OA. None of the phenotypic subgroups previously associated with mtDNA haplogroups were associated in this study.
We were not able to replicate previously published findings in the largest mtDNA association study to date. The evidence linking OA to mtDNA is not compelling at present.
Gene Polymorphism; Osteoarthritis; Pharmacogenetics
Obesity as measured by body mass index (BMI) is one of the major risk factors for osteoarthritis. In addition, genetic overlap has been reported between osteoarthritis and normal adult height variation. We investigated whether this relationship is due to a shared genetic aetiology on a genome-wide scale.
We compared genetic association summary statistics (effect size, p value) for BMI and height from the GIANT consortium genome-wide association study (GWAS) with genetic association summary statistics from the arcOGEN consortium osteoarthritis GWAS. Significance was evaluated by permutation. Replication of osteoarthritis association of the highlighted signals was investigated in an independent dataset. Phenotypic information of height and BMI was accounted for in a separate analysis using osteoarthritis-free controls.
We found significant overlap between osteoarthritis and height (p=3.3×10−5 for signals with p≤0.05) when the GIANT and arcOGEN GWAS were compared. For signals with p≤0.001 we found 17 shared signals between osteoarthritis and height and four between osteoarthritis and BMI. However, only one of the height or BMI signals that had shown evidence of association with osteoarthritis in the arcOGEN GWAS was also associated with osteoarthritis in the independent dataset: rs12149832, within the FTO gene (combined p=2.3×10−5). As expected, this signal was attenuated when we adjusted for BMI.
We found a significant excess of shared signals between both osteoarthritis and height and osteoarthritis and BMI, suggestive of a common genetic aetiology. However, only one signal showed association with osteoarthritis when followed up in a new dataset.
Osteoarthritis; Gene Polymorphism; Epidemiology
Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies (GWAS) on European subjects.
We performed a two-stage meta-analysis on more than 78 000 participants. In stage 1, we synthesised data from eight GWAS whereas data from 10 centres were used for ‘in silico’ or ‘de novo’ replication. Besides the main analysis, a stratified by sex analysis was performed to detect possible sex-specific signals. Meta-analysis was performed using inverse-variance fixed effects models. A random effects approach was also used.
We accumulated 11 277 cases of radiographic and symptomatic hip OA. We prioritised eight single nucleotide polymorphism (SNPs) for follow-up in the discovery stage (4349 OA cases); five from the combined analysis, two male specific and one female specific. One locus, at 20q13, represented by rs6094710 (minor allele frequency (MAF) 4%) near the NCOA3 (nuclear receptor coactivator 3) gene, reached genome-wide significance level with p=7.9×10−9 and OR=1.28 (95% CI 1.18 to 1.39) in the combined analysis of discovery (p=5.6×10−8) and follow-up studies (p=7.3×10−4). We showed that this gene is expressed in articular cartilage and its expression was significantly reduced in OA-affected cartilage. Moreover, two loci remained suggestive associated; rs5009270 at 7q31 (MAF 30%, p=9.9×10−7, OR=1.10) and rs3757837 at 7p13 (MAF 6%, p=2.2×10−6, OR=1.27 in male specific analysis).
Novel genetic loci for hip OA were found in this meta-analysis of GWAS.
Epidemiology; Gene Polymorphism; Osteoarthritis

domain: literature


text:
building available in the campus without affecting the apex court order.
He had said since there is space in the compound, the residents should be allowed to get approval of the building plan as originally it was planned to have nine towers and the builders came out with seven by accommodating all buyers in them.
Seven high-rise buildings of Campa Cola Housing society were constructed between 1981 and 1989. The builders had permission for only six floors. One of the compound buildings, Midtown, has 20 floors and another building, Orchid, has got 17 floors.


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Added Feb 20, 2008
This is a bag I have made from an old jeans skirt. The basic idea is that is will go completely black, but it has not been colored yet so for now it is still its original color.
The old zipper at the waist was made into a pocket at the lid of the bag.
Jeans skirt, imitation skin from an old jacket, cotton-braided-ribbon. Metal clasp
We're taking a sneak peak at the upcoming fashion design course.
This classic autumn collection has designs inspired by the Scottish countryside.
Meg's Magazine Mash Up 2014
Sew with Meg & see her final steps in sewing the cape & also see a sneak peek of Meg's new course!
Member Project of the Week
Check out this preppy fall style.
Read this funny post and watch the video to learn more about why this web seminar is great for you!
You must allow our "request for permission" request to login to Burdastyle with Facebook.

domain: design


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The denizens of the night croak in fear.
I’m not entirely proud of that line, but it fits rather well with this cheeky and over-the-top book from across the pond. Ever wish that someone would do a Tick porn parody? Well, you need help. Also, you need this book. The Frogman Trilogy does for depraved indifference, explosive action, and sex-minded losers what Kermit did for numbers and letters. Filled with crass humor – sorry, mates. Humour – that maintains a high level of wit and enough nerd references to put Chris Hardwick into seizures, this is a story told by an idiot, signifying nothing. Wait, no, this is a book that knows what it is and never apologizes for it: a fun, mature-rated romp that reminds me of the “I don’t care. I love it” attitude espoused by films like Shoot ‘em Up (Seriously, if you’ve never seen it, please go check it out. Paul Giamatti is maybe the most fun villain I’ve ever seen.) and toddlers alike.
Mark Lewis and Matt Fitch are the brain trust behind this adolescent dream come true, and may god have mercy on their souls. This book lampoons a lot of the conventions of the Big Two as well as the Comics Code and moral decency. There are a couple of side characters who show up now and again to reinforce this idea, and I have a touch of suspicion that they bear a striking resemblance to the creators. There’s a lot of meta-book gags within that exist without entirely shattering the fourth wall. “Frogman #1” is a mostly straightforward action book with heavy doses of the style of humour that litters this graphic novel. “Frogman Returns” is a whole step up the ladder in the ridiculous department, with Frog Man encountering Man Frog, which is such a callout to the biggest goofy idea in the Batman universe (that has actually become one of my favorite d-list baddies. The Animated Series elevated the very ’50s sci-fi idea to something rather engaging, and The Arkham Knight handled the story with less gravitas but made for some of my favorite moments in that game.), where we are introduced to my favorite character in the entire book who comes back to wreck sh*t in “The Death of Frogman:” a squirrel with a serious attitude issue and the nuts that women want. That’s not dirty, he’s a squirrel. (Okay, for reals, it’s dirty as hell.) We are also treated to our warped tour guide’s vision of the burning hereafter, and though it’s rough on our “hero,” it’s a treat for us reading. I wouldn’t classify Frogman as the typical antihero, he’s just the antithesis of one. Selfish, repugnant, and a sore loser (which happens so often it might as well be a state of being for him), he blunders from one disaster to another where he tends to not help roughly every situation, leading to constant comedy gold.
Each part of the trilogy has a different artist, and the fact is called out in a couple of places to great effect. Creator Matt Fitch takes on the duties in “#1,” with clean lines and dirty intentions, plus the introduction of the wondrous “Froggy Style.” The action is clear and engaging, and the bedroom scenes are . . . imaginative. “Frogman Returns” is drawn by John Aggs, and the style shifts into a more detailed and somehow even more visceral style. The squirrel that I had mentioned above is dainty, cute, and quickly dispatched with abandoned. The action steps up a bit, as a good portion of this issue involves a chase scene and a load of third-act surprises. The final chapter is helmed by Gibson Quarter, and he seems to be the sickest of the bunch. It’s a good thing. Tasked with bringing the underworld to fiery life, he goes above, beyond, and somewhat to the left of the mark and makes it a place I’ve certainly no interest in ever visiting. Our departed micromammal returns and is the instigator of a beautiful, page-length panel that any comic fan will instantly recognize, though with the relative sizes of the players tweaked, it is worth some full-bodied chuckles at the very least.
If you are of sufficient age that “Corruption of a Minor” would not apply, this is a ball and gut-buster that will have you in tears for maybe more than one reason. Froggy style.
Share the stories that move you.


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US intelligence agencies will investigate the information on the relationship of US President Donald trump and the alleged Russian interference in American elections. This was stated by the Director of the Federal Bureau of investigation (FBI), James Comey during a speech before Congress, his words, reports The Hill.
"I can promise you that we will gather the facts and see where they lead us," said he.
In February, The New York Times published an article in which, with reference to sources in diplomatic circles approved, members of the election headquarters of Donald trump had contact with senior officials of Russian intelligence. This, according to the authors, evidenced by the phone records and intercepted calls.
According to sources, the talks were attended not only by officials of the headquarters of the trump, but other associates of Republican. From the Russian side the talks were also attended by representatives of countries not belonging to the security services. The names of the participants and their content was not specified.
The Democrats advocated the creation of a special Senate Committee to investigate these charges, or for the appointment of spectracular to consider the circumstances of the case. The Republicans are blocking these initiatives, and Democrats have to work independently.
6 Jan was published the declassified version of the report prepared by the CIA, FBI and national security Agency (NSA) of the USA, which States that the President of Russia Vladimir Putin personally ordered to organize a campaign to influence the political process in the United States and to discredit the presidential candidate of the Democratic party, Hillary Clinton, to win her opponent Donald trump.
Two fighter Typhoon Royal air force were scrambled to intercept Russian planes that allegedly approached the airspace of the United Kingdom. According to the Daily Mail, the incident occurred in Scotland. The fighters were up from a military base in Lossiemouth.
Russian Maria Laecken (Kuchina) prevailed over the rivals in the sector to jump stage of the Diamond League in Eugene (USA). Champion of the world 2015, speaking under a neutral flag, in her best attempt to overcome a mark of 2.03 meters.
"Barcelona" defeated "Alaves" in the final of the Spanish Cup. The meeting was held at the stadium "Vicente calderón" in Madrid and ended with the victory of the Catalans with a score of 3:1. The blue-pomegranate Lionel Messi, Neymar and Paco alcácer. The only goal "alavesa" scored Theo Bernard françois.
The media learned of the decision of the US Navy to send to the coast of the DPRK, the aircraft carrier "Nimitz" (USS Nimitz), to increase the pressure on Pyongyang. The ship will join the already located in that area, "Ronald Reagan" and "Carl Vinson", increasing the striking force to a record level.


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Just the other day I was given the opportunity to try and answer an impossible question. The question was thus: Just how are men and masculinity represented in the media and how does this reinforce stereotypes or, indeed, reflect positively on men.
I broke new ground last week. I went jogging with an Olympic athlete. Not just any Olympic athlete, but long-distance runner Jo Pavey who has competed in five Olympics.
I’ve been getting a little introspective recently. I’ve been looking at my life in an attempt to decide how many social connections I have and how strong they are.


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You can access quick personal loan in Singapore from Licensed Moneylenders but this doesn’t mean you can get away with it. Any borrowing, whether from bank or moneylender, requires a lot of discipline. You should ensure you pay your debt on time. If you find that you are unable to pay moneylenders on time, here is what might happen, and what you can do.
Consequences of Default
This only applies to secured loan where the loan is backed by a security. You risk losing your property if you default on a secured loan. The lender repossesses the property upon default and has a right to sell the property so as to recover the outstanding loan amount. The most commonly USED securities include but are not limited to; House, Motor Vehicle, Machinery, CDs, Bank Accounts etc
Interest Keeps on Accrual
One thing that happens when you default a loan is that interest keep accruing. You are left to pay interest on top of interest. Moreover, lenders may start charging late repayment fees on the amount defaulted. The law allows them to charge a 4% late repayment fee per month on the amount due.
You may face legal action if the fail to settle the loan after the lender has provided you with a notice to pay. Always remember you signed a contract that is legally binding and an action can be taken against you in breach of contract.
Future Loan Decline
Since your credit score is affected by default or late repayment, it can paint you in a bad picture to your potential future lenders. Any time you approach a lending institution for a loan facility, your default history will always be a reference point for the decline. Banks and other lending institutions my classify you as un-creditworthy because of your bad credit history
Loan Tenure Extension
If you do not pay your loan on time, this can initiate the lender to restructure your loan so that you can be left with a manageable instalment. Loan restructuring is whereby the lender amends the loan term mostly on the loan tenure into a longer period thus spreading your loan into more manageable monthly instalments. Loan restructuring prolongs the loan repayment period making you pay more interest over time.
Poor Credit Score
All loans whether good or bad are rated by credit bureaus. When you pay your loans promptly, you build on a positive credit rating. On the other hand if you default on your loan payments, you leave a negative mark on your credit history. Having a bad credit score on your credit report is undoubtedly undesirable. With negative rating, you risk having your loans declined by lending institutions.
Before applying for a personal loan in Singapore, it is important to consider how you are going to pay the loan instalments and be sure you can do so on time.
If you are not able to meet your monthly installments, the best thing is to talk to your lender and chat the way forward.
Finally, make sure to keep up with your repayment schedule

domain: finance


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