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After years of visiting the same spot in rural Georgia, a family builds a dream farm among the oaks
Otis Scarborough and his wife, Sandy, bought the little house as a weekend place for themselves and their two sons. “We put in the azaleas and roses, plus all sorts of flowering plants,” Scarborough says. “In the spring, we put in vegetables and eat them all summer. My wife’s and her brother’s art is here…” He pauses. “It’s like a little bit of every part of our life is in this house. I know it sounds corny, but it’s true.”
Yet the house Scarborough is talking about—a functioning horse farm on a hundred acres about thirty miles outside Columbus, Georgia—didn’t start out the way it’s ended up. Purchased about fifteen years ago, it was a modular home on a gorgeous piece of land: pastures, woods, a lake, and towering old oaks. Every weekend, the Scarborough family would drive up from their home in Columbus and settle in.
Then, a few years ago, they decided to take a huge step. “One day, my wife and I thought: We love this place so much, why don’t we live here full-time?”
At first, Scarborough adds, he was nervous about it. Maybe as a daily diet they wouldn’t like the place as much. “But then I thought: I’m always happy here on weekends,” he says. “Why wouldn’t I be happy here full-time?”
Still, before they decided to commit, they began thinking about how to make the place even better. And the Scarboroughs (Otis is in real estate, Sandy is a photographer) knew exactly whom to call. On a different job, they’d worked with Jim Strickland, founder and senior partner at Historical Concepts in Peachtree City, Georgia.
A company as much about planning as architecture, Historical Concepts is a “place-making” enterprise that, among other residential projects, is behind the sport-centric communities Palmetto Bluff and Spring Island in South Carolina and Ford Plantation in Georgia, developments that pay tribute to the charming architecture and traditions of the past. “So the Scarboroughs asked me up to their lake house,” Strickland says, “and we began to talk about its possibilities.” Together the three—plus decorator Melanie Davis, landscape designer Bill Lincicome, and project manager Terry Pylant—began to put together an idea of what the house could become.


Tag Archives: Scientific Games Racing
- With SGR acquisition in hand, Sportech turns focus on global markets
November 19, 2010
Liverpool-based Sportech has released an interim statement in which it claims to have made ‘significant progress’ since its £51.4m acquisition of New Jersey-based pari-mutuel operator Scientific Games Racing (SGR) earlier this year. The integration of SGR, which has since been renamed Sportech Racing, is proceeding apace, giving the group “the...
- Sportech gets long-awaited purchase
October 5, 2010
When it overcame the bristly hurdle that was the New Jersey Racing Commission, Sportech knew that the end was nigh in their race to acquire their early Christmas present – I know it’s rather early but I did see Christmas lights up over the weekend! The present is in the...
- Sportech gets the nod for SGR acqusition
October 1, 2010
Sportech had previously been on cusp of sealing the deal in acquiring Scientific Games Racing from Scientific Games Corporation pending approval from the New Jersey Racing Commission. Well, the wait is now over, the verdict is in. The New Jersey Racing Commission has officially given Sportech the green light to...
- One more hurdle for Sportech
September 24, 2010
Anyone who is an expert at wiping the smiles off the faces of smug people should step forward right now, and head down the turnpike, taking the exit for New Jersey. The expert smile-wiper has been eagerly searching for Sportech and it’s smiley people for much of the last six...
Pala Interactive debuts New Jersey online poker site
June 7, 2017
PokerStars to United States: we’ll be back in 2014
December 31, 2013


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What's the number one pizza?
The Daily Meal claims the White Clam pizza at Frank Pepe Pizzeria Napoletana in New Haven, CT is the best. Trip Advisor states the best pizza comes from Regina Pizzeria in Boston MA. The top rated independent pizzeria is Marion’s Piazza in Dayton OH and America's biggest pizza chain is Domino's.
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domain: food


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Essays & Articles
Affordances: Commentary on the Special Issue of AI EDAM
The unwieldy acronym “AI EDAM” stands for the Journal with the unwieldy name of “_Artificial Intelligence for Engineering Design, Analysis and Manufacturing.” _They published a special issue on Affordances (2015) and asked me to comment on the collection. Here is my commentary. Here’s a quick summary:
The full article is available from Cambridge University Press as a PDF (free).
The concept of affordances has an interesting history, starting with the keen observations and thoughts of the perceptual psychologist, J.J. Gibson in the late 1970s, moving into the world of design through the 1988 publication of my book “Design of Everyday Things” (later originally titled “Psychology of Everyday Things”), and then making its way into engineering design in the 2001 paper by Maier & Fadel.
As a result of this disciplinary migration, the concept of affordance leads several rather separate lives within these different fields — ecological psychology, Design, and engineering design — with each field barely aware of the work being done in the others.
My major interest in the concept aligns with the interests of the authors of this special issue: the use of affordances as a practical tool for design. The question these papers address is how can we design and objects and systems that are practical, reliable, affordable, functional, useable, and understandable. Affordances play critical roles in all of these aspects. Whether the designer comes from the traditional background of art and architectural schools, the modern background of a human-centered, systems analysis with an iterative prototype, test, and revise philosophy, or from engineering design with its more powerful set of formal design methods and tools, the end goals are the same.
Affordances can be the bridge between the traditional engineering focus on efficiency and function with the goals of fitting people needs, desires, and emotions.
My reservations concern the disconnect between the engineering and design communities, a disconnect that goes in both directions. This collection of papers presents an excellent treatment of affordances from the point of view of engineering design, moving the engineering understanding forward in valuable ways. Now it is time to integrate this research with the existing practices within the design community. One problem is that engineers and designers publish in different journals and attend different conferences. Designers publish in journals such as Design Issues, Design Studies, and the International Journal of Design. In this collection of papers on affordances and design, the only design journal that is referenced is Design Studies and in only one paper, that of Pols. In turn the design community is ignorant of the work in engineering design. Thus, these papers are published in a special issue of AI EDAM, a name that will be foreign to people from the design community even if spelled out as Artificial Intelligence for Engineering Design, Analysis and Manufacturing.
All communities make valuable contributions from their perspective of the issue. I continue to look forward to a merging of disciplines, where the insights of all fields can be brought together to form a new, harmonious whole, with many new and exciting emergent properties.

domain: library


A new leak has detailed the specifications of the Samsung Galaxy Watch 4 and Galaxy Watch 4 Classic. The rumored smartwatch from the South Korean tech giant is said to come in two sizes – 40/44mm and 42/46mm. The smartwatch will also reportedly be manufactured from different materials such as aluminum and stainless steel. The Galaxy Watch 4 series from Samsung in two models – Galaxy Watch 4 and Galaxy Watch 4 Classic, is expected to launch along with two foldable smartphones – Samsung Galaxy Z Fold 3 and Galaxy Z Flip 3 during the Galaxy ‘Unpacked’ event later this month. have hope. According to a report by German website WinFuture, the specifications of the Samsung Galaxy 4 and Samsung Galaxy Watch 4 Classic have been revealed through PR and marketing content seen by the publication. It says that both the smartwatches are technically identical except for the dial shape and some minor differences.
Specifications of Samsung Galaxy Watch 4 and Watch 4 Classic
For the Galaxy Watch 4 Classic, Samsung is said to opt for a 1.36-inch AMOLED (450×450 pixels) display, which may feature Corning Gorilla Glass DX as well as rotating bezels. This variant will reportedly come with a 42/46mm dial size, while the vanilla Galaxy Watch 4 will come in a 40/44mm dial size and feature a 1.19-inch AMOLED display with Corning Gorilla Glass DX. The Samsung Galaxy Watch 4 Classic will pack a 361mAh battery, which is tipped to provide up to 7 days of battery life. On the other hand, the vanilla Galaxy Watch 4 will come with a 247mAh battery. Internally, there is said to be 1.5GB of RAM and 16GB of onboard storage paired with the Exynos W920 wearable chip. The Galaxy Watch 4 and Galaxy Watch 4 Classic are said to be waterproof up to 5ATM (50 metres) and have IP68 certification for dust and water resistance along with MID SID 810G military grade certification. The Samsung smartwatch will reportedly feature Bluetooth v5.0, WLAN, NFC, and optional 4G LTE connectivity. The sensor list is said to include GPS, GLONASS, among others. Both the smartwatches will run on the new Wear OS-based One UI, which the report claims will be the One UI Watch 3.5 interface. Being a fitness tracker, the Samsung smartwatch model has various health sensors including heart rate, blood-oxygen (SpO2), sleep tracking, fall detection, forecast and menstrual cycle tracking. Both will reportedly come with an electrocardiogram (EKG) sensor. As per the publication, the Samsung Galaxy Watch 4 and Galaxy Watch 4 Classic 40 will come with Sports Mode, most of which will be automatically detected once activity starts.
[Attribution to NBT]


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CHICAGO -- Penn State football great Matt Millen is known now for his work as a college football analyst and Millen is scheduled to work PSU's Sept. 1 season opener against Appalachian State at Beaver Stadium for the Big Ten Network.
Millen, a former Oakland/Los Angeles Raider, also does analyst work for Raiders' preseason games and he will call Oakland's Aug. 30 preseason game at Seattle, then catch a red-eye flight back home in time for PSU-Appalachian State.
That's a pretty demanding test for a 60-year-old -- or for anyone -- and this 60-year-old has been battling a disease that will require a heart transplant.
The Lehigh Valley native and resident revealed in the spring that he has amyloidosis, a disease in which a protein known as an amyloid is produced in bone barrow and builds up in a person's organs. In this case, the disease has attacked Millen's heart, which he said is operating at about 30 percent efficiency.
Millen played for the late Joe Paterno in the mid-to-late 1970s. A terrific defensive lineman and All-American at PSU, Millen was picked in the second round of the 1980 NFL draft by the Oakland Raiders, who moved him to inside linebacker. Millen won four Super Bowls during a lengthy NFL career, two with the Raiders, one with the San Francisco 49ers and one with the Washington Redskins.
Millen first began feeling symptoms in 2011, according to a Peter King story that ran on SI.com in the spring. After numerous tests and many doctor consults, the amyloidosis diagnosis was made roughly a year ago, according to King's story.
Millen has dropped roughly 50 pounds and now weighs in the 225 range. In an interview with PennLive during the Big Ten Media Days sessions here, it was clear his sense of humor is still in fine shape.
But there is no getting around the fact Millen will require a heart transplant.
"I'm down 50 pounds,'' Millen said.
"They want me to stay under 230 and I'm around 225. That's what I weighed when I was a junior in high school (at Whitehall), so it's been awhile."
"But my clothes fit better,'' he laughed. "Don't go on the 'chemo' diet, I don't suggest it."
"But I'm still going to need a heart,'' Millen continued.
"We're still at that process. ... You can do it at different places regionally. But I feel pretty active and so far, so good.''
Millen, who is coming off seven weeks of chemotherapy in his fight with the disease, even managed to make light of his situation when one of his doctors told him about the need for a heart transplant.
"That's what they tell me,'' Millen said, referring to the heart transplant.
"And I'll you the same thing I told the last doctor. We came in and he said, 'You're going to need a heart transplant'.
"I said, 'Let me tell you something, my heart at 30 percent is better than yours at 90 percent', and we both started laughing.
"He actually said, 'There's some truth to that based off of your years of training', and all of that stuff. You know, I just take it as it comes.''
Millen keeps pushing forward and his plan is to work a full slate of football games in the fall, beginning with the Penn State opener. He said he studied the Lions during their spring drills and is looking forward to seeing his alma mater play in 2018 without a talent group of players from 2017 that included Saquon Barkley, a fellow Whitehall High School grad.
"For the fall, I'm going to try and do a full (TV) schedule,'' Millen said.
"Right now, I have been off the 'chemo' for seven weeks as of today. Actually, I feel a little better. I can finally start to taste some things for a change.''
"As far as Penn State is concerned, what are they going to be like on the defensive side of the ball, (what are) the defensive tackles going to look like?" Millen said.
"You have linebackers, that's probably a bigger question mark. I want to see just how much better the offensive line has gotten. You have some talented kids in the running back spots but they're not going to be Saquon (Barkley).
"That's one of the fun things about college football. It's almost like a Christmas package, you know? You open it up, and what do you get?''

domain: news


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PHILADELPHIA–(BUSINESS WIRE)–Newfound, the nation’s largest one-stop-shop real estate brokerage platform, announced today it has helped another local woman achieve first-time homeownership through its sponsorship of the RiseUp Fund. RiseUp, an independent, federally-chartered nonprofit organization created by Newfound, provides a clear path toward homeownership for underserved families through education, financial assistance, and empowerment.
Ms. T. R. from Crum Lynne, PA was able to purchase a home in the Greater Philadelphia region with the help of a combined $11,500 in contributions from the RiseUp Fund and its partner organizations ESSA Bank & Trust, Achievability, and American Heritage Federal Credit Union. Ms. R. had little or no out-of-pocket costs to close on her home and stated, “Working with RiseUp and Achievability, my homebuying process went really smoothly, I felt supported every step of the way, and now I get to start on the fun stuff, decorating and making this home my own.”
Newfound, a certified B Corporation since 2016 and the first B Corporation real estate brokerage in the world, is dedicated to giving back to the communities in which it serves. Through its preferred non-profit, the RiseUp Fund, the company donates $100 to the fund for every home it helps its clients buy or sell with 100% of those funds supporting eligible families with homebuyer grants and programs.
Using the ALICE (Asset Limited, Income Constrained, Employed) classification as defined by the United Way, RiseUp serves low-to-moderate-income individuals and families who need financial help to secure their own home. Awards are based upon demonstrated financial need, geography, and successful completion of a HUD-certified homebuyer education seminar. All programs are offered in Philadelphia and surrounding counties free of charge.
“By reaching out across private, public, and non-profit partnerships, we can accomplish so much more for so many more people desiring home ownership. We are grateful for partners like ESSA Bank & Trust, who sponsored this $5000 grant, to help low-to-moderate income families purchase their first home,” said Dr. Suzanne Garber, CEO of the RiseUp Fund. Jamila Harris-Morrison, Executive Director of Achievability, echoed that sentiment, “ACHIEVEability is proud to partner with RiseUp to help Black residents realize their dreams of home ownership and build generational wealth.” Bruce Foulke, CEO of American Heritage Federal Credit Union also agreed, “We are happy to support our local community members in achieving the dream of home ownership, thanks to great organizations like RiseUp.”
The RiseUp Fund offers a host of education, counseling, and mentoring programs to set up traditionally underserved populations for successful homeownership long after the purchase of their first home. Ms. T. R. will have access to a HUD-certified mentor to support her during this important transition period from renter to homeowner.
To apply for one of the RiseUp programs or become a partner in the Fund, please visit www.riseupfund.org.

domain: finance


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Consumer VR has been here for less than a year. We got dev kits early on at the office, and started downloading a lot of apps to play with. To be honest I didn’t try any VR game: I only tried creation tools, pretty much all of them. First was Tilt Brush, really loved it. Then GravitySketch, Medium, Quill, SculptrVR, and a few others…
Just transformed a tiny closet into a VR station at home ? finally some time to practice VR creation during the holidays! pic.twitter.com/SjqaPJXgK5
— alban denoyel (@albn) December 24, 2016
I didn’t have much bandwidth over the past 6 months to really spend the time I wanted to discover them. But with the Christmas break, I decided to bring the office Oculus back home. I don’t have a spare room, so I turned a closet into a VR closet 🙂 And everyday I spent a few hours sculpting or painting in VR. Within 7 days, I went from this shitty dino to this bull:
This medium is amazingly powerful. The learning curve for me was incredibly fast. It would have taken me months to be able to get to similar results with a traditional 3D software. But VR is a new paradigm of creation, where you don’t have to think too much on how you draw things, you just draw them. There is no mouse, the mouse is your hand.
We live in a 3D world, and until now we’ve mostly expressed ourselves with 2D mediums (drawing, photography, video…) except for sculpture or 3D software, which both require advanced skills and training. With the new VR creation tool, anybody can express themselves in a 3D space, which is the natural way to convey a concept or an emotion.
For artists and designers, it will allow much more creativity freedom as well as a faster execution – but this goes much beyond art and design. What blows my mind is to see 5 year-old kids posting 3D drawings on Sketchfab. When you think about it, drawing a house in 3D is even more intuitive than on a 2D sheet of paper, first because the house is in 3D in the real world, and second because in 2D you have to think about perspective, proportions etc, whereas when drawing in VR in 3D space you don’t have to think about those.
Creating in VR is highly addictive. Once I start a piece, I just want to stay in VR until it’s done. Next step is to 3D print my best pieces!
If you create in VR, I’d love to see some of your work on Sketchfab. If you don’t create in VR yet, I wish you’ll get a chance to give it a try soon.

domain: artistic


text: The author deals with a central question for the ethnomusicology of the Orient: the ‘neutral tone’ also imprecisely called ‘quarter-tone’. His article reviews the evolution of musical intervals in several traditions of the Turkic and Persian worlds since the early twentieth century. Analysing differences between nomadic and sedentary societies, J.D. searches an explanation to the absence of neutral tone in the classical musical tradition of Turkistan and, more generally, in the traditions of Turkic peoples. Based on a precise and complex musicological work of intervals measures, enriched with references to ancient recordings, with pictures and fieldwork material, this study shows how one distinguishes “two trans-national cultural areas” in regard to the different perceptions of intervals by, respectively, Turks and Persians, and to their building of music through notes progression. In regard to these facts, the author also examines how these modal traditions have evolved till the present, ending with the example of the Azerbaijani muqam.


I've been working on this knitted turtle forever. I have finally finished the knitting part only to find out that putting it together is so much harder. Here are all the pieces. the top is the shell and the bottom is the tummy, tail, feet, and head. I've gotten some of it together but what a pain this is to figure out. Anyway hopefully I'll have a complete photo tomorrow and then I can get started on trying to knit some farm animals.
OH and I'm really excited that my friend who is a crochet expert is coming to visit this month. Hopefully she'll be able to get me started. :)


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Dragon Age: origins is a role playing video game developed by BioWare and Published by Electronic Arts. It is the first game in the Dragon Age franchise, and was released For Microsoft Windows, Play Station 3, and Xbox 360 in November 2009, and For OS X in December 2009. Edge of Reality developed the game’s console version. Set in the fictional kingdom of Ferelden during a period of civil strife, the game puts the player in the role of a warrior, mage, or rogue coming from an elven, human, or dwarven background. The player character is recruited into the Grey Wardens, an ancient order that stands against demonic forces known as DarkSpawn, and is tasked with defeating the Archdemon that commands them and ending their invasion, know as the Blight. The game is played from a third person perspective that can be shifted to top down perspective. You can download to Tiny Troopers Game Clicking on this link.
Dragon Age origins Game Screenshot For PC:
Throughout the game, players encounter various companions, who play major roles in the game’s plot and game Play and accompany the player throughout the game. BioWare described Dragon Age: Origins as a dark heroic fantasy set in a unique world, and a spiritual successor to their previous Baldur’s Gate and Neverwinter Nights franchises. Its setting was inspired by The Lord of the Rings and A song of Ice & Fire, and was described by BioWare as a mix between high fantasy and low fantasy,
Development of the game began in 2002, and lasted over six years. BioWare employed more than 144 voice actors, and hired Inon Zur to Compose the game’s music. origins received critical acclaim upon released, with praise mostly directed at its story, setting, characters, music and combat system. It sold more than 3.2 million copies, and 1 million pieces of downloadable content. Its multiplayer year end accolades included game of the year and best Role Playing awards from several gaming publications.
BioWare released several instances of downloadable content after the game’s initial launch, an expansion pack for the game titled Awakening in March 2010, and two sequels, Dragon Age II and Dragon Age: Inquisition, were released in 2011 and 2014 respectively.
Dragon Age: Origins is an action role playing game. The player is a Grey Warden, part of an order of elite fighters, whose task is to defeat the Archdemon and save the world from a disastrous event called the Blight. Players create their own Grey Warden Character, Customizing gender and appearance as well as choosing a race and class. The available classes are warriors, Who perform strong physical attacks; rogues, who carry out stealth attacks and steal items from other characters; and mages, who cast spells on enemies, create combo spells, and support other party members.
How to install
installation proces is very easy, just need to understand the way of installation. You must have torrent software are before installation. It is necessary for this.
- Downloading game file
- After Downloading, open folder and extract it
- Play and Enjoy it
- That’s it
follow these steps, if you have an problem you can ask inside the comment, section it try of solve you problem as seen possible.

domain: hobby


text:
10:00 a.m. – 12:00 noon
Fee: $22 per person
Phipps Ceramic Studio Instructor
Spend the morning in this fun workshop where you will work closely together as you learn basic hand-building techniques such as pinching, coiling, and clay slab-construction to make vases, flower pots, and hanging garden ornaments.
The instructor will cover your creations with a food-safe glaze of your choosing, and then have them fired and ready to take home on Saturday, May 11 (in time for Mother’s Day!)

domain: design


Telewest has grabbed a lucrative piece of cable real estate from rival NTL, by securing total ownership of Cable London.
But NTL immediately criticised the deal saying Telewest had paid too much for its 50 per cent stake. The deal values Cable London at around £1 billion, or £5,000 per customer.
The North London cable operator was owned 50:50 by Telewest and Comcast, but when NTL bought Comcast last year, competition rules required one of them to buy Cable London outright.
Telewest had first refusal to buy the 50 per cent of Cable London that it didn't already own from NTL at a price set by NTL. NTL announced the price, of £428 million, after the London Stock Exchange closed last night.
Had Telewest refused the price, NTL would have had to buy the stake at that price. But Telewest, which saw a merger with Cable & Wireless Communications slip out of its hands and into NTL's last month, quickly decided to grab the stake.
By 8.30pm last night, Telewest had agreed with shareholders to raise cash for the purchase from a rights issue, where one new Telewest share would be offered, at 213 pence, for every 11 Telewest shares, to raise around £416 million.
Telewest today said it was "delighted" with the deal. "It's prime real estate. It's got some very attractive residential areas," said a Telewest spokesman.
Cable London operates four franchises in North London in lucrative areas including Camden and Islington. Spice Girl Mel C is a Cable London customer. Cable London also has several large business customer including Haringey council.
Even though NTL was prepared to pay the £428 million price tag itself, it said it was a high price for Telewest to pay.
"We valued it and came out at that price, but it is high," said an NTL spokesman.
But NTL would have preferred to have taken ownership of Cable London, which is surrounded by NTL and Cable & Wireless Communications franchises.
"In the context of the price we're paying for CWC, £428 million would have been easy. We would have happily taken it on," said the NTL spokesman.
NTL bought the consumer operations of Cable & Wireless Communications for £8.2 billion on 26 July. (see Newswire 26 July, 1999)
Would you want to live in a world without memes?
Traditional theories debunked by new study
Scientists closer to developing material capable of splitting water for better storage of solar energy
Experiments needed to see if the material works in the real world
Developers first in the queue to test TensorRT and TensorFlow integration tools running on Nvidia GPUs


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I made this card for the challenge over at CES this week; does 6 flowers count as a frenzy?! It’s more than I normally have on my cards anyway. If anyone thinks the card looks familiar, it was based on a design I saw a while back in a card making magazine.
The flowers are a combination of foundation white blooms (from Wild Orchid Crafts) inked with Tim Holtz distress inks, seam binding rolled up into ‘roses’ and a crochet flower courtesy of my mother-in-law. Here is a close up of the flowers;
I would like to enter the card in the following challenges;
1) CES Challenge (flower frenzy)
2) Papertake Weekly (anything goes)
Ok, that’s my very quick post for tonight so thanks for stopping by,
Woohoo, it’s Friday! And I have Monday off so am looking forward to a whole 3 days of crafting, although I suppose I should do some housework as well 😉
I thought I would start by sharing this card I made using the super cute Princess Anya (No. 2) from The Greeting Farm and my gorgeous new Lost & Found: Madison Avenue paper pad from MME.
I stamped the image onto patterned paper so I could paper piece the dress and crown then added a little bit of shading with a ProMarker although this doesn’t show up too well on the photo. Here’s a close-up anyway;
I have just bought some foundation white blooms from Wild Orchid Crafts and had fun inking, chalking and stamping on them to see what effects I could achieve; I think you might be seeing quite a lot of them on my cards now! The one on this card was chalked with pink and brown chalks and stamped with a script stamp in brown ink. I used a paper strip punched with a Martha Stewart punch, some pink seam binding and pearls, also from Wild Orchid Crafts, to finish it off.
I am entering the card in the following challenges;
1) Wild Orchid (white + 1 – that will be pink in my case!)
2) Simon says Stamp (anything goes)
3) TGF Farm Fresh Monday (anything goes)
Hope you all enjoy a fabulous weekend,


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Forza Horizon 2 is a fantastic racing game and a must-own for Xbox One owners. Now, it’s gotten a piece of free DLC in the form of the new 2016 Mazda MX-5. The car makes its debut in the game for months before it goes on sale to the public. Those who download the game can win one by competing in the new Time Trial Rivals Contest. There is also a new Mazda MX-5 Car Pack available for download that contains the free car in addition to three other cars.
The Time Trials Rivals contest ends on April 30, and all you need to do is navigate to the Mazda MX-5 ad landing experience on the Xbox One. Enter there and then play the game and get a fast time – the two best will be flown to Los Angeles in June, with the winner getting the car.

domain: entertainment


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Balinese Traditional(31 items)
Welcome to the Balinese Traditional Collection at NOVICA.
Featured Reviews on Balinese Traditional
Beautiful wood carving
Intricate carving; excellent craftsmanship; the wood stain is a bit lighter in color which is just what I wanted. Very pleased with my purchase.
This unique piece of art is stunning!! The detailing is beautiful. It was my daughters favorite gift.
Wow! I love theses earrings, the length is perfection. The details and craftsmanship is magnificent. The quality is beyond the price charged. Tons of complements.
Made Mulyani Hand-carved wood masks and panels
"My parents and my brother taught me to make sculptures. I started by watching them carving wood at home. I was excited with the final results and worked hard at learning how to create them."
... read more
Popular Balinese Traditional
Amethyst and Sterling Silver Balinese Style Cuff Bracelet, "Twilight Goddess"$139.99
The delicate intricacy of traditional Balinese silver work is showcased in this cuff bracelet from Buana in Indonesia. The sterling silver cuff features elaborate wire and beading motifs, complemented by a darkly oxidized background. A glorious 4.5 carat faceted oval amethyst centers the design.
Hand-Carved Suar Wood Lotus Flower Relief Panel from Bali, "Lotus Altar"$109.99
Indonesian artisan Made Mulyani hand-carves this amazing floral motif wall panel from native suar wood. She honors the influence of traditional art in Bali by creating an intricately engraved lotus flower surrounding by symmetrical leaves and petals.
Circular Floral Wood Wall Relief Panel from Indonesia, "Padma Parade"$99.99
The flower is a sacred lotus with great importance in Buddhist traditions, associated with holiness and divinity. Made Mulyani of Indonesia presents the padma in this wall relief panel, hand-carved from suar wood with a brown finish.


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I digested this book slowly over a number of weeks; I couldn't put it down, but I didn't want the story to end. This was one of the most interesting,..Show More » original, imaginative works of fiction I have read in years. Before I was finished I had order my own "to keep" copy of the hardback. Yes, the author delved into the dark side of life, but that dark side of the characters was necessary to drive the plot. I would recommend this book to anyone who can keep an open mind, enjoys great character development and appreciates a realistic ending.
It is very hard to write a concise review of this book, as there is so much one could say about its strengths and weaknesses. Vast sections were extr..Show More »emely tedious, yet other, longer, sections were riveting and deeply engaging. I agree with an earlier reviewer's opinion that the novel could have done with a bit more editing. Some of the exposition is difficult to get through, and can be confusing at times. I say this as a reader who is not easily bored, and tends to enjoy the sorts of long realist novels most people find boring. Ultimately, once I got into the guts of this novel, I found it hard to put aside. I'd say the first hour or two, and the last couple hours of the audio version were not all that engaging, but I think there are a number of reasons for this, mostly personal. Others may find the Venestrom strain of the novel more interesting than I did.
The novel contains a good deal of fairly graphic sexual violence, and isn't for those who might be sensitive to this sort of thing. It is also very devoted to detail, so you will always know what the characters make themselves for lunch, for example. But I found this aspect of the novel interesting, and I think it enhanced the atmosphere and character development.
A very worthwhile audiobook. The narrator is phenomenal, and I appreciated that he captured the characters' voices and emotions without exaggeration or affectation. His narration increased the tension where appropriate, without being overwrought. Easily among the best audiobook narrators I've ever encountered.
This was another great listen. I enjoyed it more than the first in the trilogy, but that is purely personal preference. The tone of this one is not ..Show More »quite as dark as the first, and as a result lacks some of the tension, but I thought the overall plot was more interesting. This may be because we learn more about Lisbeth, and she's more present in this novel than in the first.
Again, Larsson is devoted to a lot of minute detail. Easily bored readers may find that parts of this novel seem sort of out of place, especially as there are a number of episodes that aren't related to the overall mystery. I personally enjoyed all of the threads that weave through this novel, because they are so expertly character driven. Sadly, it appears the audio version of the third book in the trilogy will be abridged.
If I have one complaint, it's that the translator makes a few mistakes in his choice of certain English words, with slightly amusing results, e.g. "noisome."
Saul Reichlin is excellent again as the narrator. This is exactly the sort of narration I look for in an audiobook, rather than a dramatization of the work. As I said in my review of the first book, I think he captures the characters' voices perfectly, without affectation or awkwardness.
I live in Beijing. I drive or take the subway several times a week and that is when I listen to Audible books. I do not listen to them at home. If ..Show More »I did, I would go through my Audible library much too quickly and my credit card balance would, all too soon, reflect the damage. I am highly disciplined about this. When I get to the door of my apartment, the book clicks off, and podcasts or music must suffice during housework or down time. I know that this is a slippery slope, so I am far too wise to make exceptions.
I listened to the last four or five hours of this book while baking, taking a bath and, finally, lying on my bed, transfixed. Unacceptable!
It breaks my heart that Stieg Larsson is no longer with us. On the other hand, it is going to make it a lot easier for me to return to a regime of no Audible.com books at home.
Some readers have found the detail in the book overwhelming. For me they were an important part of the texture of the story which moves like real life. When the author puts so much at stake for the characters, the realistic details become loaded--which of them will prove to be crucial, life changing? Which of them are simply part of the unimportant background? If Larsson had not created such engaging and fascinating characters or a situation so charged with danger and dark possibility, they would be tiresome. Instead, I found myself picking my way through them as through a mine field.
In addition, the plot works like a well oiled machine, a very complex machine. In the end you must just give yourself up to it and live it out to the end with Salander, Blomkvist and the fifteen or twenty other memorable characters in the book. Brilliant work!
It is rare that a series gets stronger as it goes along, but Hornets' Nest is a terrific finale. When I got to the last part of the book, I sat for f..Show More »ive hours straight so that I could find out what happened. It is a great feminist novel, though many readers might not notice...
Sometimes when you're done listening to a book, you just can't stand the silence that follows. This is precisely the case here. I miss Lisbeth. I miss..Show More » Simon's voice. I miss thinking about what Larsson was going to do with the plot.
Simon Vance is the perfect reader for this exciting conclusion to the trilogy. I'm ready to listen to it again so I can pick up more detail. Excellent.
A totally different writer could have taken the key characters and put together a Larrson-worthy book. This is SO not it. Why? There are a tremendous ..Show More »number of monologues in this book where either the narrator or 1 character tell you what happened in the past OR describe something they could not possibly know. These monologues are very long and tedious and take the place of action and plot.

domain: literature


The circuit is composed of four phase shift opamp stages each with a JFET used as a variable resistor. Part of the circuit I do not understand is the DC biasing arrangement. I can see that it uses a 4.5V Zener diode to provide the 1/2 VCC supply as this circuit runs off single 9VDC supply. I do not understand how the 4.5VDC gets to the stages. Do R6/R9/R12/R15 provide the DC component to the stages? Or does R2/R3 simply bring the DC to the first stage and it gets passed through each stage?
Finally, I can't figure out the purpose of R18, the 1k resistor at the output of the last stage.


text:
Wachusett 7, Shrewsbury 1
Monday, April 29, 2013, at Holden
Junior right-hander Owen Gibbons struck out 10 while firing a two-hitter for the No. 2 Mountaineers (9-1, 3-0 Midland A) at home. Jordan Teevens and Kyle Smith each went 2 for 4 for Wachusett. Jay Reynolds tripled and scored in the sixth inning for the No. 6 Colonials (6-3, 1-2), and Jeff Svendsen had Shrewsbury's other hit in the fourth.
S — Spencer Resnick, Sam Hayes (5) and Michael Centerbar
W — Owen Gibbons and Cam Ruziak
Updated: Sunday, June 2, 2013, 5:35 p.m.


text:
Eadweard Muybridge.He's the bomb. Don't believe me? He was anenglish pioneer in capturing motion in photography. He created the zoopraxiscope which created moving images. for real. An interesting technique he would do is is capture the body in multiple positions on a single page. pretty sweet huh? He would do this by having the figure in a completely dark background. With the shutter open he would shine a light on the subject and click it on and off as the body moved, thus capturing the full movement. The dude has skills.
Here's some fun trivia about the man, the myth, the legend.
In 1887 he discovered his wife had a lover. So what did he do? He shot them man, right after he said "Good evening, Major, my name is Muybridge and here is the answer to the letter you sent my wife" ....Ok maybe that was over reacting...but eh i mean,..ok I cant really defend that.


text:
French Food Friday - Lyonnaise Salad
It is nearly the weekend and I have started to think about what I will be making.
For lunch I think a Lyonnaise Salad sounds rather appealing and it is quick and easy to make.
Both the recipe and the photo come from the gourmet traveller website, one of my favourites ever since I lived in Sydney.
2 cups (loosely packed) frisée
2 witlof, leaves separated
½ cup coarsely torn flat-leaf parsley
¼ cup finely chopped chives, plus extra to serve
80 ml olive oil (1/3 cup)
300 gm piece of bacon, cut into lardons
1 garlic clove, bruised
2 tbsp white wine vinegar
1.Poach eggs in a saucepan of simmering salted water until cooked to your liking (3-4 minutes for soft yolks), drain, keep warm.
2. Meanwhile, for croûtons, heat butter and oil in a frying pan over medium-high heat until butter foams, then cook bread, in batches, turning once, until golden (1-2 minutes each side). Drain on absorbent paper, then when cool enough to handle, break into rough pieces and place in a large bowl with frisée, witlof, parsley and chives. Set aside.
3.Meanwhile, heat 1 tbsp oil in a frying pan over medium-high heat, add bacon and garlic, sauté until crisp (3-4 minutes). Transfer with a slotted spoon to frisée mixture (discard garlic).
4. Add remaining oil and vinegar to the pan, mix to combine, season to taste and remove from heat. Drizzle over salad, toss lightly to combine, divide among serving plates and serve topped with a poached egg.
Bon fin de semaine ♥♥ Leeann x


text:
[Show abstract][Hide abstract] ABSTRACT: The significance of matricellular proteins during development and cancer progression is widely recognized. However, how these proteins actively contribute to physiological development and pathological cancer progression is only partially elucidated. In this study, we investigated the role of the matricellular protein Cysteine-rich 61 (CYR61) in pancreatic islet development and carcinogenesis. Transgenic expression of CYR61 in β cells (Rip1CYR mice) caused irregular islets morphology and distorted sorting of α cells, but did not alter islets size, number or vascularization. To investigate the function of CYR61 during carcinogenesis, we crossed Rip1CYR mice with Rip1Tag2 mice, a well-established model of β cell carcinogenesis. Beta tumors in Rip1Tag2CYR mice were larger, more invasive and more vascularized compared to tumors in Rip1Tag2 mice. The effect of CYR61 on angiogenesis was fully abrogated by treating mice with the anti-VEGFR2 mAb DC101. Results from in vitro assays demonstrated that CYR61 modulated integrin α6β1-dependent invasion and adhesion without altering its expression. Taken together, these results show that CYR61 expression in pancreatic β cells interferes with normal islet architecture, promotes islet tumor growth, invasion and VEGF/VERGFR-2-dependent tumor angiogenesis. Taken together, these observations demonstrate that CYR61 acts as a tumor-promoting gene in pancreatic neuroendocrine tumors.
[Show abstract][Hide abstract] ABSTRACT: Tumor progression depends on angiogenesis. Vascular endothelial growth factor (VEGF) receptors (VEGFRs) are the main signal transducers that stimulate endothelial cell migration and vessel sprouting. At present, only VEGFR2 is targeted in the clinical practice.
To develop new, anti-angiogenic nanoparticles (immunoliposomes, ILs), that redirect cytotoxic compounds to tumor-associated vascular cells.
Pegylated liposomal doxorubicin (PLD) was targeted against VEGFR2- and VEGFR3-expressing cells by inserting anti-VEGFR2 and/or anti-VEGFR3 antibody fragments into the lipid bilayer membrane of PLD. These constructs were tested in vitro, and in vivo in the Rip1Tag2 mouse model of human cancer.
The combination treatment with anti-VEGFR2-ILs-dox and anti-VEGFR3-ILs-dox was superior to targeting only VEGFR2 cells and provides a highly efficient approach of depleting tumor-associated vasculature. This leads to tumor starvation and pronounced reduction of tumor burden.
Nanoparticles against VEGFR2 and -3 expressing tumor-associated endothelial cells represent a promising and novel anti-cancer strategy.
No preview · Article · Jul 2015 · Journal of Drug Targeting
[Show abstract][Hide abstract] ABSTRACT: Tumor growth depends on the formation of new blood vessels (tumor angiogenesis) either from preexisting vessels or by the recruitment of bone marrow-derived cells. Despite encouraging results obtained with preclinical cancer models, the therapeutic targeting of tumor angiogenesis has thus far failed to deliver an enduring clinical response in cancer patients. One major obstacle for improving anti-angiogenic therapy is the lack of validated biomarkers, which allow patient stratification for suitable treatment and a rapid assessment of therapy response. Toward these goals, we have employed several mouse models of tumor angiogenesis to identify cell populations circulating in their blood that correlated with the extent of tumor angiogenesis and therapy response. Flow cytometry analyses of different combinations of cell surface markers that define subsets of bone marrow-derived cells were performed on peripheral blood mononuclear cells from tumor-bearing and healthy mice. We identified one cell population, CD45(dim)VEGFR1(-)CD31(low), that was increased in levels during active tumor angiogenesis in a variety of transgenic and syngeneic transplantation mouse models of cancer. Treatment with various anti-angiogenic drugs did not affect CD45(dim)VEGFR1(-)CD31(low) cells in healthy mice, whereas in tumor-bearing mice, a consistent reduction in their levels was observed. Gene expression profiling of CD45(dim)VEGFR1(-)CD31(low) cells characterized these cells as an immature B cell population. These immature B cells were then directly validated as surrogate marker for tumor angiogenesis and of pharmacologic responses to anti-angiogenic therapies in various mouse models of cancer.
[Show abstract][Hide abstract] ABSTRACT: The extensive intratumor heterogeneity revealed by sequencing cancer genomes is an essential determinant of tumor progression, diagnosis, and treatment. What maintains heterogeneity remains an open question because competition within a tumor leads to a strong selection for the fittest subclone. Cancer cells also cooperate by sharing molecules with paracrine effects, such as growth factors, and heterogeneity can be maintained if subclones depend on each other for survival. Without strict interdependence between subclones, however, nonproducer cells can free-ride on the growth factors produced by neighboring producer cells, a collective action problem known in game theory as the "tragedy of the commons," which has been observed in microbial cell populations. Here, we report that similar dynamics occur in cancer cell populations. Neuroendocrine pancreatic cancer (insulinoma) cells that do not produce insulin-like growth factor II (IGF-II) grow slowly in pure cultures but have a proliferation advantage in mixed cultures, where they can use the IGF-II provided by producer cells. We show that, as predicted by evolutionary game theory, producer cells do not go extinct because IGF-II acts as a nonlinear public good, creating negative frequency-dependent selection that leads to a stable coexistence of the two cell types. Intratumor cell heterogeneity can therefore be maintained even without strict interdependence between cell subclones. Reducing the amount of growth factors available within a tumor may lead to a reduction in growth followed by a new equilibrium, which may explain relapse in therapies that target growth factors.
Preview · Article · Jan 2015 · Proceedings of the National Academy of Sciences
[Show abstract][Hide abstract] ABSTRACT: Epithelial to mesenchymal transition (EMT) is a program defined in epithelial cells and recognized as playing a critical role in cancer progression. Although melanoma is not a cancer of epithelial cells, hallmarks of EMT have been described to play a critical role in melanoma progression. Here we demonstrate that long term TGFβ exposure can induce a dedifferentiated EMT-like state resembling a previously described invasive phenotype (EMT-like). TGFβ-induced EMT-like is marked by the downregulation of melanocyte differentiation markers, such as MITF, and the upregulation of mesenchymal markers, such as N-cadherin, and an increase in melanoma cell migration and cell invasion. Pharmacological interference shows the dependency of TGFβ-induced EMT-like on the activation of the PDGF signaling pathway and the subsequent activation of PI3K in human melanoma cells. Together, the data provide novel insights into the transcriptional plasticity of melanoma cells that might contribute to tumor progression in patients and propose avenues to therapeutic interventions.This article is protected by copyright. All rights reserved.
Preview · Article · Nov 2014 · Experimental Dermatology
[Show abstract][Hide abstract] ABSTRACT: The cellular changes during an epithelial-mesenchymal transition (EMT) largely rely on global changes in gene expression orchestrated by transcription factors. Tead transcription factors and their transcriptional co-activators Yap and Taz have been previously implicated in promoting an EMT, however, their direct transcriptional target genes and their functional role during EMT have remained widely elusive. We have uncovered a previously unanticipated role of the transcription factor Tead2 during EMT. During EMT in mammary gland epithelial cells and breast cancer cells, levels of Tead2 increase in the nucleus of cells, thereby directing a predominant nuclear localization of its co-factors Yap and Taz via the formation of Tead2/Yap/Taz complexes. Genome-wide chromatin immunoprecipitation/next generation sequencing in combination with gene expression profiling reveals the transcriptional targets of Tead2 during EMT. Among these, zyxin contributes to the migratory and invasive phenotype evoked by Tead2. The results demonstrate that Tead transcription factors are critical regulators of Yap/Taz cellular distribution and together they control the expression of genes critical for EMT and metastasis.
Preview · Article · Feb 2014 · Journal of Cell Science
[Show abstract][Hide abstract] ABSTRACT: Neuroendocrine tumors are well vascularized and express specific cell surface markers, such as somatostatin receptors and the glucagon-like peptide-1 receptor (GLP-1R). Using the Rip1Tag2 transgenic mouse model of pancreatic neuroendocrine tumors (pNET), we have investigated the potential benefit of a combination of anti-angiogenic treatment with targeted internal radiotherapy.
[Lys40(Ahx-DTPA-111In)NH2]-exendin-4, a radiopeptide that selectively binds to GLP-1R expressed on insulinoma and other neuroendocrine tumor cells, was co-administered with oral vatalanib (an inhibitor of vascular endothelial growth factor receptors (VEGFR)) or imatinib (a c-kit/PDGFR inhibitor). The control groups included single-agent kinase inhibitor treatments and [Lys40(Ahx-DTPA-natIn)NH2]-exendin-4 monotherapy. For biodistribution, Rip1Tag2 mice were pre-treated with oral vatalanib or imatinib for 0, 3, 5, or 7 days at a dose of 100 mg/kg. Subsequently, [Lys40(Ahx-DTPA-111In)NH2]-exendin-4 was administered i.v., and the biodistribution was assessed after 4 h. For therapy, the mice were injected with 1.1 MBq [Lys40(Ahx-DTPA-111In)NH2]-exendin-4 and treated with vatalanib or imatinib 100 mg/kg orally for another 7 days. Tumor volume, tumor cell apoptosis and proliferation, and microvessel density were quantified.
Combination of [Lys40(Ahx-DTPA-111In)NH2]-exendin-4 and vatalanib was significantly more effective than single treatments (p < 0.05) and reduced the tumor volume by 97% in the absence of organ damage. The pre-treatment of mice with vatalanib led to a reduction in the tumor uptake of [Lys40(Ahx-DTPA-111In)NH2]-exendin-4, indicating that concomitant administration of vatalanib and the radiopeptide was the best approach. Imatinib did not show a synergistic effect with [Lys40(Ahx-DTPA-111In)NH2]-exendin-4.
The combination of 1.1 MBq of [Lys40(Ahx-DTPA-111In)NH2]-exendin-4 with 100 mg/kg vatalanib had the same effect on a neuroendocrine tumor as the injection of 28 MBq of the radiopeptide alone but without any apparent side effects, such as radiation damage of the kidneys.
[Show abstract][Hide abstract] ABSTRACT: An epithelial-mesenchymal transition (EMT) underlies malignant tumor progression and metastatic spread by enabling cancer cells to depart from the primary tumor, invade surrounding tissue and disseminate to distant organs. EMT also enriches for cancer stem cells (CSCs) and increases the capacity of cancer cells to initiate and propagate tumors upon transplantation into immune-deficient mice, a major hallmark of CSCs. However, the molecular mechanisms promoting the tumorigenicity of cancer cells undergoing an EMT and of CSCs have remained widely elusive. We here report that EMT confers efficient tumorigenicity to murine breast cancer cells by the up-regulated expression of the pro-angiogenic factor vascular endothelial growth factor A (VEGF-A) and by increased tumor angiogenesis. Based on these data, we propose a novel interpretation of the features of CSCs with EMT-induced, VEGF-A-mediated angiogenesis as the connecting mechanism between cancer cell stemness and tumor initiation.
[Show abstract][Hide abstract] ABSTRACT: We have identified the zinc-finger transcription factor Kruppel-like factor 4 (Klf4) among the transcription factors that are significantly downregulated in their expression during epithelial-mesenchymal transition (EMT) in mammary epithelial cells and in breast cancer cells. Loss and gain of function experiments demonstrate that the down-regulation of Klf4 expression is required for the induction of EMT and for metastasis . In addition, reduced Klf4 expression correlates with shorter disease-free survival of subsets of breast cancer patients. Yet, reduced expression of Klf4 also induces apoptosis in cells undergoing TGFβ-induced EMT. Chromatin immunoprecipitation/deep-sequencing in combination with gene expression profiling reveals direct Klf4 target genes, including E-cadherin (), N-cadherin (), vimentin (), β-catenin (), VEGF-A (), endothelin-1 () and Jnk1 (). Thereby, Klf4 acts as a transcriptional activator of epithelial genes and as a repressor of mesenchymal genes. Specifically, increased expression of Jnk1 () upon down-regulation of its transcriptional repressor Klf4 is required for EMT cell migration and for the induction of apoptosis. The data demonstrate a central role of Klf4 in the maintenance of epithelial cell differentiation and the prevention of EMT and metastasis.
[Show abstract][Hide abstract] ABSTRACT: The extracellular matrix molecule tenascin-C (TNC) is a major component of the cancer-specific matrix, and high TNC expression is linked to poor prognosis in several cancers. To provide a comprehensive understanding of TNC's functions in cancer, we established an immune-competent transgenic mouse model of pancreatic β-cell carcinogenesis with varying levels of TNC expression and compared stochastic neuroendocrine tumor formation in abundance or absence of TNC. We show that TNC promotes tumor cell survival, the angiogenic switch, more and leaky vessels, carcinoma progression, and lung micrometastasis. TNC downregulates Dickkopf-1 (DKK1) promoter activity through the blocking of actin stress fiber formation, activates Wnt signaling, and induces Wnt target genes in tumor and endothelial cells. Our results implicate DKK1 downregulation as an important mechanism underlying TNC-enhanced tumor progression through the provision of a proangiogenic tumor microenvironment.
[Show abstract][Hide abstract] ABSTRACT: Gene expression profiling has uncovered the transcription factor Sox4 with upregulated activity during TGF-β-induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells. Sox4 is indispensable for EMT and cell survival in vitro and for primary tumor growth and metastasis in vivo. Among several EMT-relevant genes, Sox4 directly regulates the expression of Ezh2, encoding the Polycomb group histone methyltransferase that trimethylates histone 3 lysine 27 (H3K27me3) for gene repression. Ablation of Ezh2 expression prevents EMT, whereas forced expression of Ezh2 restores EMT in Sox4-deficient cells. Ezh2-mediated H3K27me3 marks associate with key EMT genes, representing an epigenetic EMT signature that predicts patient survival. Our results identify Sox4 as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2.
[Show abstract][Hide abstract] ABSTRACT: The lymphatic system, the network of lymphatic vessels and lymphoid organs, maintains the body fluid balance and ensures the immunological surveillance of the body. In the adult organism, the de novo formation of lymphatic vessels is mainly observed in pathological conditions. In contrast to the molecular mechanisms governing the generation of the lymphatic vasculature during embryogenesis, the processes underlying pathological lymphangiogenesis are less well understood. A genome-wide screen comparing the transcriptome of tumor-derived lymphatic endothelial cells with that of blood vessel endothelial cells identified paralemmin-1 as a protein prominently expressed in lymphatic endothelial cells. Paralemmin-1 is a lipid-anchored membrane protein that in fibroblasts and neurons plays a role in the regulation of cell shape, plasma membrane dynamics and cell motility. Here, we show that paralemmin-1 is expressed in tumor-derived lymphatic endothelial cells as well as in lymphatic endothelial cells of normal, non-tumorigenic tissue. Paralemmin-1 represses cell migration and delays the formation of tube-like structures of lymphatic endothelial cells in vitro by modulating cell-substrate adhesion, filopodia formation and plasma membrane blebbing. While constitutive genetic ablation of paralemmin-1 expression in mice has no effect on the development and physiological function of the lymphatic system, the loss of paralemmin-1 impaired tumor-associated lymphangiogenesis. Together, these results newly identify paralemmin-1 as a protein highly expressed in lymphatic endothelial cells. Similar to its function in neurons, it may link the cytoskeleton to the plasma membrane and thereby modulate lymphatic endothelial cell adhesion, migration and lymphangiogenesis.
[Show abstract][Hide abstract] ABSTRACT: The Hippo (Hpo) pathway is a novel signaling pathway that controls organ size in Drosophila and mammals and is deregulated in a variety of human cancers. It consists of a set of kinases that, through a number of phosphorylation events, inactivate YAP, a transcriptional co-activator that controls cellular proliferation and apoptosis. We have identified PTPN14 as a YAP-binding protein that negatively regulates YAP activity by controlling its localization. Mechanistically, we find that the interaction of ectopic YAP with PTPN14 can be mediated by the respective WW and PPxY motifs. However, the PTPN14 PPxY motif and phosphatase activity appear to be dispensable for the negative regulation of endogenous YAP, likely suggesting more complex mechanisms of interaction and modulation. Finally, we demonstrate that PTPN14 downregulation can phenocopy YAP activation in mammary epithelial cells and synergize with YAP to induce oncogenic transformation.
[Show abstract][Hide abstract] ABSTRACT: The epithelial-mesenchymal transition (EMT), a prerequisite for cancer progression and metastasis formation, is regulated not only at the transcriptional but also at the post-transcriptional level, including at the level of alternative pre-mRNA splicing. Several recent studies have highlighted the involvement of splicing factors, including epithelial splicing regulatory proteins (Esrps) and RNA-binding Fox protein 2 (Rbfox2), in this process. Esrps regulate epithelial-specific splicing, and their expression is downregulated during EMT. By contrast, the role of Rbfox2 is controversial because Rbfox2 regulates epithelial as well as mesenchymal splicing events. Here, we have used several established cell culture models to investigate the functions of Rbfox2 during EMT. We demonstrate that induction of an EMT upregulates the expression of Rbfox2, which correlates with an increase in Rbfox2-regulated splicing events in the cortactin (Cttn), Pard3 and dynamin 2 (Dnm2) transcripts. At the same time, however, the epithelial-specific ability to splice the Enah, Slk and Tsc2 transcripts is either reduced or lost completely by Rbfox2, which might be due, in part, to downregulation of the expression of the Esrps cooperative factors. Depletion of Rbfox2 during EMT did not prevent the activation of transforming growth factor-β signaling, the upregulation of mesenchymal markers or changes in cell morphology toward a mesenchymal phenotype. In addition, this depletion did not influence cell migration. However, depletion of Rbfox2 in cells that have completed an EMT significantly reduced their invasive potential. Taken together, our results suggest that during an EMT, Rbfox2-regulated splicing shifts from epithelial-to mesenchymal-specific events, leading to a higher degree of tissue invasiveness.Oncogene advance online publication, 25 February 2013; doi:10.1038/onc.2013.50.
[Show abstract][Hide abstract] ABSTRACT: Most cancer deaths are due to the systemic dissemination of cancer cells and the formation of secondary tumors (metastasis) in distant organs. Recent years have brought impressive progress in metastasis research, yet we still lack sufficient insights into how cancer cells migrate out of primary tumors and invade into neighboring tissue, intravasate into the blood or the lymphatic circulation, survive in the blood stream, and target specific organs to initiate metastatic outgrowth. While a large number of cellular and animal models of cancer have been crucial in delineating the molecular mechanisms underlying tumor initiation and progression, experimental models that faithfully recapitulate the multiple stages of metastatic disease are still scarce. The advent of sophisticated genetic engineering in mice, in particular the ability to manipulate gene expression in specific tissue and at desired time points at will, have allowed to rebuild the metastatic process in mice. Here, we describe a selection of cellular experimental systems, tumor transplantation mouse models and genetically engineered mouse models that are used for monitoring specific processes involved in metastasis, such as cell migration and invasion, and for investigating the full metastatic process. Such models not only aid in deciphering the pathomechanisms of metastasis, but are also instrumental for the preclinical testing of anti-metastatic therapies and further refinement and generation of improved models.
Full-text · Article · Feb 2013 · Molecular oncology

domain: biology


text:
here has been a substantial increase in the number of dogs presenting with a dry, hacking cough in the Bitterroot Valley. Most are current on their bordatella vaccinations. Consequently, dogs are at risk even though they are current on their vaccinations. The dogs are, obviously, contagious prior to being symptomatic as well.
Is it Kennel Cough?
If this current bug is a form of kennel cough, it is a strain not included in the latest bordatella vaccination. Bordatella vaccinations, similar to human flu vaccines, are dependent on inclusion of the strain currently in the environment to be effective. The Bordatella vaccine also contains Parainfluenza, which is what several of the local veterinarians believe is causing the current infections.
Infected dogs can have the virus for a week to 20 days before symptoms appear. The infection being a virus versus a bacterial infection is virtually impossible to kill. The best an owner can do is provide supportive care. Antibiotics are frequently prescribed, though their efficacy is questionable. Cough suppression medication is the most effective thing you can give to your dog. Your veterinarian can prescribe a cough medication or give you the proper dosage amount for an over the counter, human cough medication. The infected dogs we have seen are not running a fever. If your dog does run a fever, consult your veterinarian for proper treatment.
You’ll know if your dog becomes infected. They will start coughing as though there is a foreign object in their throat they are trying to expel. The cough is extremely violent from the start. The dogs we have seen do not have a fever or any additional symptoms. Their energy level as well as their appetite appears unaffected and they seem perfectly healthy other than the horrible cough they present. The cough is more prevalent when the dog is up and moving around.
Dogs become infected by inhaling the virus from an infected dog. As stated previously, dogs appear contagious prior to the onset of a cough. Dog parks, veterinary clinics and boarding facilities, like Freckled Paws K9 Hostel are environments where dogs come into close contact with potentially infected dogs. And since the vaccine doesn’t appear to provide any protection the only way to ensure your dog doesn’t become infected is to keep them from having any contact with other dogs.
The Good News
The good news is the cough appears much worse than the actual infection. We have been in close contact with several local veterinarians and have not had any reports of infected dogs failing to heal within a week to two weeks after initial symptoms show up. The infected dog’s lungs remain clear and there doesn’t appear to be any fever associated with the disease.
Be aware if you have reservations with us or any other boarding facility, in the immediate future, your dog is at increased risk of contracting this virus. Even a trip to your veterinarian or a dog park increases the chances of your dog becoming infected. There is nothing we can do to prevent transmission of the virus other than making dog owners aware that it is prevalent in the Bitterroot Valley at this time. We also are not accepting dogs that are actively coughing into our facility.
If you have additional questions, you can contact us or your veterinarian.

domain: medical


Aluminum plate products have a wide range of applications in various fields. 4x8 standard aluminum sheets standardize and generalize the application process, and are convenient for production, transportation, and storage. 4x8 aluminum panels have become an economical, convenient, and efficient choice.
Specification of Chalco 4x8 aluminum plate
|Alloy series||1000, 2000, 3000, 5000, 6000, 7000 series.|
|Temper||O-H112, T3-T8, T351-T851, H111, H112, H12-H18, H22-H28, H32-H38 etc.|
|Thickness||1/16″, 1/8″, 3/16″, 1/4″；0.2-350mm；12 gauge, 14 gauge, 16gauge, etc.|
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|Comparison table of 4 * 8 aluminum plate size units|
|foot||4 foot×8 foot||4ft×8ft||4′×8′|
|Inch (in)||48 inch×96 inch||48in×96in||48”×96”|
|MM (mm)||1219 millimeter×2438 millimeter (1220×2440)||1219mm×2438mm (1220×2440)||1219×2438mm (1220×2440mm)|
Hot selling sizes of Chalco 4x8 aluminum plate
|Thickness||Weight per area|
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|1 aluminum sheet||1″||1in||25.4|
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Hot selling: 3003 H22 polished aluminum diamond plate, 6061 T6 mill finish aluminum diamond plate, etc. 3000 and 6000 series aluminum is ideal for making diamond plates used in toolbox, stairs, trailer ramps, trucks, and more. It offers excellent formability, drillability, and weldability while its raised diamond pattern ensures slip resistance.Quick Quote
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Aluminum perforated plates are highly popular metal mesh products with diverse hole sizes and shapes. They serve various purposes in industry, decoration, equipment protection, screens, ceilings, curtain walls, ventilation, and more.Quick Quote
Aluminum expanded metal 4x8
Aluminum expanded metal sheets are cut and stretched to create diamond-shaped openings, reducing weight and metal usage. They allow the passage of light, liquids, sound, and air while offering a decorative touch. These sheets primarily serve protective or safety functions, like window and machinery protection.Quick Quote
The features of Chalco 4x8 aluminum plate
- The 4x8 aluminum plate has a wide range of applications. The size is relatively regular and suitable for use in multiple scenarios;
- Good rigidity, high strength, silver metallic luster, and good decorative performance;
- Multiple coatings are available, with uniform adhesion, bright and long-lasting colors; The Pvdf fluorocarbon coating based on Kynar-500 and Hylur500 can be used for 25 years.
- Low density, light weight, and aluminum sheets are formed in the factory with no need for on-site cutting. They can be fixed on the skeleton, making installation and construction convenient and fast.
- The aluminum plate undergoes a process of first processing and then painting, which can be processed into various complex geometric shapes such as flat, curved, spherical, etc.
- The coating film has non adhesive properties, making it difficult for pollutants to adhere to the surface, thus making the surface cleaner.
Cooperative fields of Chalco 4x8 aluminum plate
- Automobile covering parts
- Truck trailer skin
- Ship deck/side/bottom/outboard engine, etc.
- Electrical panels and mechanical product panels
- Patterned plates are widely used for staircase ramps or truck ramps
- Perforated boards, patterned boards, etc. are widely used in building panels, partitions, and wall art
- Patterned plates are widely used in electrical equipment such as refrigerator partitions
- Mirror panels and painted aluminum plates are widely used in the production of advertising signs, nameplates, and license plates
Production capacity of Chalco 4x8 aluminum plate
The production and processing process includes melting aluminum ingots, rolling into aluminum coils, annealing, and 4x8 size cutting.
Aluminum plate cutting can be achieved through various methods, such as sawing, shearing, CNC engraving machines or laser machines. Chalco uses CNC equipment for cutting, which can better control dimensions and reduce production errors. Moreover, there are no burrs after cutting, and the edges of aluminum plates can also be rounded.
When cutting aluminum plates, PVC film can be covered on the surface or paper can be sandwiched between two aluminum plates as needed, which can better protect the surface of the aluminum plate from damage and prevent oxidation.
After cutting, the outer surface of the 4x8 aluminum plate is completely wrapped with waterproof and moisture-proof PVC film, and sufficient moisture-proof agent is added to prevent oxidation of the aluminum plate. Then wrap it with hard kraft paper to prevent injury to the aluminum plate. Finally, steel strips are used for reinforcement.
FAQ for purchasing Chalco 4x8 aluminum plate
How to calculate the 4x8 aluminum plate？
To calculate the weight of 4×8 aluminum plate, we can use measuring tools. However, without measurement tools, we need to use calculation formulas and aluminum plate thickness to calculate the weight of the aluminum plate.
To obtain the approximate weight using the weight calculation formula, it is necessary to know the length, width, and thickness of the aluminum plate;
Weight=density of aluminum plate * volume of aluminum plate (density of pure aluminum is 2.7g/cm3)
|Thickness||Types of aluminum plate||Density||Volume||Weight|
|1/16”(inch)||4×8 plate||ρ=2.7g/cm3||4726 cm3||12.759 kg|
|1/8”(inch)||9451 cm3||25.518 kg|
|1/4”(inch)||18902 cm3||51.036 kg|
|1/2”(inch)||37805 cm3||102.072 kg|
By using a calculation formula, it is easily to calculate the weight of 4×8 aluminum plate for different thicknesses.
For example: the weight of 1/4 inch 4×8 aluminum plate is 51kg;
What is the price of 4x8 aluminum plate？
The price of 4x8 aluminum plates is not fixed, and it is necessary to refer to the trend of aluminum prices on that day. In addition, aluminum plates are the quantity of products processed from aluminum metal through a series of processes, and their prices are also affected by processing fees. Therefore, the specific price of aluminum plate needs to be considered in conjunction with market and production factors.
Chalco, as the production and supplier of 4x8 aluminum plates, has its own production line to ensure the maximum inventory and shortest production lead time. Chalco will customize personalized solutions based on your needs and provide competitive prices for our aluminum plates. Batch orders can also apply for discounts.
Where can I buy 4x8 aluminum plates and how can I choose a reliable supplier for 4x8 aluminum plates?
4x8 aluminum plate, as a standard specification aluminum plate, can be purchased on many platforms, such as metal suppliers and distributors, aluminum manufacturers, e-commerce platforms, etc. However, it is not easy to choose a trustworthy long-term partner who can provide overall project solutions.
- Chalco provides 4x8 aluminum plate full alloy series processing, covering various alloy grades from 1000 to 7000 series;
- Chalco independent aluminum plate production, cutting and surface treatment lines, with complete products, sizes, and colors;
- Chalco has collaborated with numerous well-known enterprises such as Mercedes Benz, Volkswagen, Ford, Lingyu Motors, Iveco, and others, resulting in significant brand effects.
- Chalco can provide complete quality assurance and quality inspection certificates from production to testing, ensuring product quality;
- Chalco can provide free samples as a reference to dispel customer concerns from various aspects of production.
Chalco can provide you the most comprehensive inventory of aluminum products and can also supply you customized products. Precise quotation will be provided within 24 hours.Get a quote


Greenville conference looks at ‘Arts and the Public’
Greenville’s commitment to public art made the city a natural choice for an academic conference this weekend that will explore the connection between the arts and the community.
About 300 scholars and artists from around the world are expected to attend “Arts and the Public,” a conference of the Association for the Study of the Arts of the Present opening Thursday at the Hyatt Regency in downtown Greenville.
“We feel Greenville is a perfect location,” said Cameron Bushnell, an organizer of the conference and associate chair of Clemson University’s English Department.
“Public art is a commentary on the city and its values,” Bushnell said. “Art is a means to grace the city but also can provide critical commentary on the city, a way to understand the city. That’s what this conference is interested in exploring.”
The conference also will look at the way architecture impacts the public.
Greenville Mayor Knox White and Liberty Bridge architect Miguel Rosales will present the opening plenary address today at 5:30 p.m. Two members of Clemson University’s architecture faculty, Peter Laurence and David Franco, also will participate in the opening panel.
Doris Sommer, a professor of romance languages and literature at Harvard University, will be the final keynote speaker at the conference on Friday. Sommer’s work has focused on integrating academic learning with civic engagement.
In addition, on Saturday the conference will host Wangechi Mutu, a Kenyan-born artist whose work embraces a variety of themes from colonial history to contemporary African politics and the international fashion industry.
Other panels will feature scholars and artists from across the United States as well as from Poland, France and Japan.
“It’s really a national and international conference,” Bushnell said.
The association’s membership includes scholars and artists working at the nexus of a wide range of contemporary art forms, encompassing visual, literary, performing, musical and media arts.
“The association is interested in the intersections between practicing artists and literary scholars for the most part,” Bushnell said. “The association was formed because other associations didn’t seem to be picking up this interdisciplinary work.”
The conference is sponsored by Clemson’s College of Architecture, Arts and Humanities. In addition to Bushnell, the primary organizers are Clemson English Department professors Mike LeMahieu and Angela Naimou, and the department’s administrative assistant Emily Clarke.
For more information on the conference, see the website http://www.clemson.edu/asap7/.
For the latest in local arts news and reviews, follow Paul Hyde on Facebook and Twitter: @PaulHyde7.


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Malta International Airport is located nearby to the capital city of Malta Island, Valletta, and nearby to Luqa and Gudja. For this reason the airport is also often referred to as the Valletta, Luqa or Gudja International Airport, however, it’s official IATA code remains as MLA. A large number of airline companies offer Malta International Airport departure flights, of which two carriers use the airport as a hub location. Passengers on flights from the airport have access to a wide range of facilities, and the entire airport complex is designed for the comfort of disabled passengers. Several forms of transport are available to the airport as well.
Malta Airport is the only airport serving the entire Maltese archipelago, and is therefore an important entry and exit point for the island. It can be easily accessed from most areas of Malta, but is particularly nearby to Valletta. Passengers may drive their own vehicles to the airport and use the parking areas provided. Short-term parking is available, as well as cheaper long-term parking, for persons who need to stay for longer than twelve hours. The parking area is in close proximity to the terminal building, and therefore no shuttles are required for transport. Passengers who prefer public transport can take one of the many buses that serve the airport. The Express Routes X1, X2, X3, X4, X5 and X6 are most popular as they make fewer stops along the way than the local route buses. There are private shared-ride services available from Malta Transfer, or passengers can simply use a conventional taxi to reach their departure flight. A taxi from Valletta to the airport will cost approximately 15 Euro.
The airport served approximately 3.5 million passengers in 2011, which was a 6.46% increase from the previous year, even though the total number of aircraft movements were less, at around 28,022. The airport is used by a large number of airline carriers, all of which offer international flights, as there are no other airports on the island of Malta. Two of the main companies present are Air Malta and Ryanair with a significant number of flights to Amsterdam, Athens, Brussels, Frankfurt, London, Rome, Vienna, Munich, Dublin, Edinburgh, Madrid, Pisa, Stockholm and Leeds/Bradford. These flights, amongst others, operate throughout the year, but a couple of destinations are only served by seasonal flights, such as Wroclaw, Glasgow, Krakow, Valencia, Newcastle upon Tyne, Norwich, Marseille and Lourdes.
Malta International Airport departure flights are offered by the following companies as well: Air Berlin, Air France, Alitalia, EasyJet, EgyptAir Express, Emirates, Libyan Airlines, Lufthansa, Luxair, Monarch, Thomas Cook Airlines, Travel Service, Thomson Airways and Vueling Airlines. A large number of the airport’s passengers head for the London airports of Gatwick, Heathrow and Luton, the large Rome-Fiumicino Airport, Frankfurt, Manchester, Munich, Brussels, Paris and Dusseldorf.
In the single terminal building of Malta Airport departing passengers will find the check-in counters, security check-points and airline boarding gates. Since that all flights from the airport are international, passengers should arrive at least two hours before their scheduled departure, or even earlier if any special considerations are required, for example, if you are travelling with a baby or young children. At most, passengers will wait about twenty-five minutes for check-in, and will then pass security screening for entry into the departure lounge. If permitted by the airline company concerned, passengers can use online check-in for convenience.
Although the luggage allowance may differ for each airline carrier, most will accept baggage of a maximum of 20kg for economy-class passengers, and baggage of up to 30kg for business-class travellers, without any additional charges. However, baggage may not weight more than 32kg, even if the overweight charges are paid. Although officials at the security check-point will not regulate how many items of hand luggage you are carrying, hand luggage regulations according to your airline company will be applicable. All items will be x-ray screened, and to help proceedings, passengers should remove all items from their pockets such as coins, keys and other metallic objects for placement onto the tray before screening. Laptops or any other large electrical item will be separately screened, and have any liquids ready for inspection as well. Liquids should total no more than one litre, and each liquid should be in containers of no more than 100ml each. All containers are then placed into a transparent and re-sealable plastic bag. These quantities do not apply to liquid items that are purchased from the duty-free store in the departure area.
If you arrive early for your flight from Malta International Airport, there are a number of interesting shops to browse, or you could stop for a bite to eat at one of the restaurants or fast food outlets. Certain shops such as Samsonite and Classic Opticians are found in the Central Area Level 0, while shops such as Bling, Diamonds International, Swarovski, Simply Malta, Playmobil and Spirit of Malta are all located on the Departures Level 1. Fast food outlets include KFC, McDonald’s and Burger King, while Costa Coffee in the Check-in hall is a great place to stop for a snack and something to drink.
Additional facilities at Malta Airport include a lost and found office, a spacious parenting room, a chapel, baggage wrap services and a conference facility on level 1. The conference room can seat up to eighty people, but can also be divided into smaller areas seating between twenty and forty delegates. Throughout the terminal, there are wireless internet connections available, and accessible restrooms.
Further information regarding Malta International Airport departures is available from the following telephone numbers: +356 2124 9600 or +356 2169 7800. Specific flight information is available at +356 5230 2000, with each call costing 1 Euro.Back to top

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Last updated May, 2017


When you are trying to spin a wooden bowl out of green wood, knowing what you’re doing is almost the entire battle. There are so many different tools other her to help you, from the best lathes to things like a cnc engrave machine where you can do almost all of it on the internet without even having to get started on the lathe until you’re complete done with the exception of the thing actually being made.
CNC versus the lathe is a long standing dilemma of whether or not it is better to make things with technology or simple handcrafting skills. There are so many things you can make on a lathe and there are so many things you can make on a cnc machine ,figuring out which one you want to do is a bit tricky.
The nice thing about spinning things out of wood on a lathe is it is like coaxing useful, utilitarian shapes out of nature. A cnc engraving machine doesn’t usually feel the same way. A cnc machine, while it can be used to create art, doesn’t generate the same feel of man-meets-nature that a lathe does. When you work with a lathe, you are coaxing different shapes out of the wood. You take a big, chunky log and take the time to spin a wooden bowl out of it. You start at the edges of the log and shape the log into a funnel. Then you carve out all of the middle except the pillar holding it in.
Then you pull up the bottom of the bowl and attach it to the lathe, and spin out the rest of the pillar that holds it on. Your options for having fun handcrafting different things out of wood with a lathe is a lot more fun than a cnc machine. Your cnc machine usually feels like pure work, while the lathe can feel like a lot of fun with your hands. A lathe is very much like a potter’s wheel, while a cnc machine is a lot like a printer that prints things three dimensionally. When you are in the mood for stuff to be according to plan, work with a cnc machine. When you are in the mood for something to be art, use a lathe.


Viewers of Disney XD have a few more things to look forward to, on both sides of the Atlantic. Plans for a remake of the beloved family-friendly Volkswagen Beetle, Herbie, are currently in development. Not just that, but leading up to the release of Spider-Man: Homecoming, Disney XD is going to flood their channels in the U.K. and Ireland with web-slinger content.
TVLine reported that a representative for Disney XD confirmed a potential reboot series is underway based around Herbie. Herbie, the talking VW Bug, has been the centerpiece of numerous projects: The Love Bug (the 1968 film, and his first appearance); Herbie, The Love Bug (a 1982 television series); and Herbie: Fully Loaded (the 2005 film starring Lindsay Lohan).
The new series will be written by Travis Braun (Criminal Minds: Beyond Borders) and Tom Burkhard and Matt Dearborn (Zeke and Luther, Even Stevens) will serve as executive producers. As far the cast is concerned, TVLine states that Disney XD is currently on the lookout for a boy or girl to cast as the lead role.
Here is their description of the possible lead: “Lili/Landon is ‘part scientist, part entrepreneur, part daredevil’ and realizes, when her/his parents go missing, that they’ve secretly been working on a government project: a talking car named Herbie. Herbie is key to helping the kid reunite with her/his parents, but a gang of criminals also wants to get its paws on the state-of-the-art vehicle.”
Reboots are something Spider-Man fans are more than familiar with by now, but for the run-up to the newest version of Spidey, Disney XD has something special in mind. On July 3rd, Disney XD’s channels in the United Kingdom and Ireland will begin a month long celebration of the wall-crawler in promotion for the release of Spider-Man: Homecoming.
Sky and Virgin Disney Xd + 1 will be playing the entire run of Ultimate Spider-Man, which features Drake Bell (Drake & Josh) as the voice of Peter Parker. Disney XD will premiere a 15-minute behind-the-scenes special for Spider-Man: Homecoming, as well as six shorts about the web-head’s origin.
“This is the first time that we have created a takeover dedicated to Spider-Man, arguably one of the most popular characters from the Marvel universe and one of Stan Lee’s most venerated creations,” Disney Channel UK’s David Levine said today,”The wall-crawler continues to draw kids to Disney XD so what better way to pay tribute to his genius than by giving him his own channel throughout the month of July when the whole world will be going Spidey crazy.”
Spider-Man: Homecoming opens in U.K. theaters on July 5th and opens in the U.S. on July 7th.