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Published online Oct 15, 2004. doi: 10.3748/wjg.v10.i20.2958
Revised: January 3, 2004
Accepted: January 8, 2004
Published online: October 15, 2004
AIM: To develop an efficient animal colitis-associated carcinogenesis model and to detect the expression of β -catenin and p53 in this new model.
METHODS: Dysplasia and cancer were investigated in mice pretreated with a single intraperitoneal injection of 20 mg/kg body mass of 1,2-dimethylhydrazine prior to three repetitive oral administrations of 30 g/L dextran sulfate sodium to give conditions similar to the clinically observed active and remission phases. Immunohistochemical staining of β - catenin and p53 was performed on paraffin-imbedded specimens of animals with cancer and/or dysplasia, those without dysplasia and the normal control animals.
RESULTS: At wk 11, four early-invasive adenocarcinomas and 36 dysplasia were found in 10 (90.9%) of the 11 mice that underwent 1,2-dimethylhydrazine-pretreatment with 3 cycles of 30 g/L dextran sulfate sodium-exposure. Dysplasia and/or cancer occurred as flat lesions or as dysplasia-associated lesion or mass (DALM) as observed in humans. Colorectal carcinogenesis occurred primarily on the distal portion of the large intestine. No dysplasia and/or cancer lesion was observed in the control groups with 1,2-dimethylhydrazine pretreatment or 3 cycles of 30 g/L dextran sulfate sodium exposure alone. Immunohistochemical investigation revealed that β -catenin was translocated from cell membrane to cytoplasm and/or nucleus in 100% of cases with dysplasia and neoplasm, while normal membrane staining was observed in cases without dysplasia and the normal control animals. Nuclear expression of p53 was not detected in specimens.
CONCLUSION: A single dose of procarcinogen followed by induction of chronic ulcerative colitis results in a high incidence of colorectal dysplasia and cancer. Abnormal expression of β -catenin occurs frequently in dysplasia and cancer. This novel mouse model may provide an excellent vehicle for studying colitis-related colon carcinogenesis.


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Hello everyone! :)
Please have a look of this picture below.
This is a huge signboard of Free Help store in Kakogawa.
You can find some blue birds in the paint work.
They are the symbol of FREEHELP.
This work of art was painted by a well-known Japanese artist Seitaro Kuroda whose works are given various prizes for his powerful appeals for peace.
How meaningful his work is, isn't it.
This work attracts passenger's attention a lot and gives calm atomosphere for entire VERDE MALL, a shopping street in the south of Kakogawa station where our store is located.
Now, let us bring up the profile of Seitaro Kuroda.
He was born in Osaka in 1939.
His energetic and powerful personality shows himself more attractive.
He is renowned as an illustrator and also a graphic designer.
Through creating fine arts, he got a lot of awards internationally.
Briefly speaking, he is a great artist.
By the way, if you are in or from Kansai region, the west side of Japan, you must be familiar with this logo.
These are the Kuroda designed stickers of FM802, a commercial radio station broadcasting on 80.2 FM to Kansai region.
Furthermore, his strong appeal for peace is shown in his art works.
Please have a look again our signboard design picture below.
So what does the combination of the 2 flasks mean?
Each flasks are coloured in blue and red, and written upside down each other.
In my opinion, the red one seems to be the mushroom-shaped smoke caused after the tragic event happens.
For the other example of the location of Mr. Kuroda's works in Hyogo prefecture, you can find one at HOSINOKOYAKATA Youth Nature Hall in Himeji city.
In most of his works, you can notice the existence of birds as if he enthrusts his birds with his wish for peace.
Unfortunately, one of his great and peaceful design of FREEHELP store in Kakogawa will be lost soon after our Kakogawa brunch store closes.
How sad it is! I cannot stop crying!
The removal of this signboard will be inevitable, since the sign is painted on the wall directly.
However, we will do our best for conservating our meaningful signboard.
Incidentally, the interior of our Kakogawa branch store is like this.
Is this like a Boutique Parisienne in France, n'est-ce pas?
To our delight, we often have overseas guests and volunteers who live around Kakogawa city.
In the United states and in Europeern countries, for example, there are much more charitable activities and people who are energetic for volunteer events than Japan: we must pay respect to the people and welcome to our store.
Why don't you come and stop by our FREEHELP store?
And let's take a look at Mr. Kuroda's amazing art design thinking about the meaning of PEACE.

domain: artistic


He said the spectacular festival is aimed at reviving the selfless spirit of camaraderie between people of all shades of belief and practice.
The PM's day-long visit comes about a week after his younger brother Shahbaz Sharif led a delegation to Riyadh but apparently failed to mend ties.
Nawaz Sharif also encouraged the more than 80,000 people who were displacing almost a year of fighting to return to their homes.
Prime Minister Narendra Modi has written a letter to his Pakistani counterpart Nawaz Sharif which was delivered by Foreign Secretary S Jaishankar when he called on him here today.
Nawaz Sharif has told Saudi King Salman that he will soon send a high-level delegation to Riyadh to discuss cooperation for the strikes on Yemen, a top diplomat said.
A 24-year-old petition seeking Pakistan Prime Minister Nawaz Sharif's permanent disqualification from holding public office over money laundering and having assets worth billions of rupees abroad has been dismissed by a court.
A Pakistani court today turned down the request of a petitioner to summon Prime Minister Nawaz Sharif in a two-decade-old case against him for allegedly possessing assets worth billions of rupees abroad.
Iranian Foreign Minister Mohammed Javad Zarif called on Sharif and also met army chief General Raheel Sharif and discussed the raging conflict in Yemen.


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Mac Miller’s Drug Dealer Sentenced to 11 Years in Prison
Drug Dealer Gets 11 Years in Prison
4/18/2022 1: 28 PM PT
One of the drug dealers who supplied fentanyl-laced pills to Mac Miller just received his sentence after copping a plea last year — and he’s going to prison for a long time.
Ryan Reavis will be behind bars for 10 years and 11 months after pleading guilty in November to one count of distributing fentanyl. The sentence is longer than what Reavis himself had asked for — 5 years — but shorter than the 12.5 years prosecutors were gunning for.
Remember … the feds say Reavis supplied the deadly oxycodone pills to Mac’s alleged drug dealer, Cameron Pettit … on orders from Stephen Walter, who also recently pled guilty to distributing fentanyl. Reavis claimed Monday that he was merely a middleman.
He claimed that he didn’t know that the pills he was selling were fake. Despite this, the judge seemed to have dished out an even-handed sentence — but not before hearing a statement from MM’s mother, Karen Meyers.
It said, in part, “He would never, ever, knowingly take a pill containing fentanyl.” He wanted to live, and was excited about the future. “The hole in my heart will always remain.” She also stated that the alleged dealers/suppliers in the case were solely responsible.
As we reported … Reavis was first arrested back in 2019 out in Arizona — where authorities say they found a bogus doctor’s notepad, from which he presumably filled prescriptions. They also claimed that they found firearms, drugs, including prescription-only pills and marijuana.
Just to keep it all straight, Reavis (the alleged supply) is the first of three men who have been charged and received his sentence. Walter, the alleged runner, has not yet been sentenced. Pettit, the alleged dealer is still on trial.
I have been writing professionally for over 20 years and have a deep understanding of the psychological and emotional elements that affect people. I’m an experienced ghostwriter and editor, as well as an award-winning author of five novels.

domain: news


[Music] Kiddo Milianer ft. Obadice x Mesh – Raba : Download and Stream Kiddo Milianer, Obadice, Mesh Mp3 Songs Audio
Awards winner rapper “Obadice” alongside with mesh noni, the “streetvibe” crooner kiiddo miliana as also been recognize by MTNng (kiddo kuddy buddle) however everyone knows that kiddo Milli is a very good talented star, enjoy Raba.
Listen and Download “Raba” by “Kiddo Milianer ft. Obadice x Mesh”.
Download, Share and Enjoy!!!


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New open mic starting at Mad Donna’s in East Nashville hosted by Brad Edwards!
Tags: corporate juggernaut comedy brad edwards utimate comedy
Corporate Juggernaut is a series of comedy shows in Nashville, TN brought to you by Gary Fletcher, Brandon Jazz & The High Watt.
SKETCH COMEDY PLAYLIST
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A legend that dates back to ancient Roman and Greek times, The Evil Eye came to prominence during the Ottoman Empire and is defined as receiving an envious glare from people when you have success and praise is put upon you. It is believed that given it brings you misfortunes and bad luck. It became such a strong belief that entire cultures have turned to the act of praising God for blessings to avoid the powers of the Evil Eye.
Struck from 1 oz of pure silver, this coin from the geniuses at Coin Invest Trust mimics the brightly coloured amulets worn by millions. Featuring deep, rich blues and whites in among the tremendous minted details, this is a truly mystical collector coin!

domain: history


Sun 09-12-2018 22:22 PM
RIYADH, 9th December, 2018 (WAM) — The 39th session of the GCC Summit has concluded at Al Diriyah Palace in Riyadh in the presence of His Highness Sheikh Mohammed bin Rashid Al Maktoum, Vice President, Prime Minister and Ruler of Dubai, who led the UAE delegation.
The UAE delegation included H.H. Sheikh Mansour bin Zayed Al Nahyan, Deputy Prime Minister and Minister of Presidential Affairs; H.H. Sheikh Abdullah bin Zayed Al Nahyan, Minister of Foreign Affairs and International Cooperation, Mohammad bin Abdullah Al Gergawi, Minister of Cabinet Affairs and the Future, Dr. Anwar bin Mohammed Gargash, Minister of State for Foreign Affairs, Sheikh Shakhbout bin Nahyan bin Mubarak Al Nahyan, UAE Ambassador to Saudi Arabia, and Khalifa Saeed Sulaiman, Director-General of Dubai Protocol and Hospitality Department.
WAM/Hazem Hussein/MOHD AAMIR


We’re kicking off Giving Tuesday early this year! Your donation today will be matched up to $10K, doubling your impact! If you donate $50 today, the Reader will receive $100.
The Reader is now a community-funded nonprofit newsroom. Can we count on your support to help keep us publishing?
“A great chance to educate the public has been botched in Chicago,” fumes Jed Perl in the New Republic (July 26), panning the video-intensive Art Institute exhibit “Seurat and the Making of La Grande Jatte.” He blames marketing. “The video screens, the digitalized rehashings of the painting, the photo murals, the jazzed-up gallery architecture, and the inclusion of what are believed to be easy-looking interludes of Renoir and Monet: all this is meant to make visitors feel at home. You go to the museum and discover that you could just as well have booted up your Mac.”
Salvation inflation. That’s how sociologist Alan Wolfe describes some of today’s allegedly conservative churches’ spirituality in an interview published in Books and Culture (March/April) and reprinted in Martin Marty’s “Context” (June): “I define grade inflation by the fact that over the 30 years I’ve been teaching, every year I assign less and less, and every year the grades get higher and higher…. To some degree we’ve seen that with salvation as well. People confess fewer and fewer sins, and are rewarded with more and more.”
Chicago Wilderness’s “Mighty Acorns” youth education program brings more than 8,000 children to natural areas three times a year for three consecutive years. The children are in fourth through sixth grade, and most of them come from schools in poverty-stricken areas. As Colleen Kulesza of the Max McGraw Wildlife Foundation explains it in CW Journal (July), the cooperative program continues despite a drop in the annual budget, from $75,000 in 1998 to $20,000 today. “Money to bus school children to natural areas has become the biggest need overall,” she writes. “Each agency has found grants or sponsors and some have had to start charging for the program.”
“SBC has won the latest battle in the great phone wars,” acknowledges Martin Cohen of the Citizens Utility Board (“Cub Voice,” Summer). “But after extracting a 30 percent increase from the Illinois Commerce Commission (ICC) in ‘wholesale’ rates–the amount that other phone companies pay to use SBC’s network–the company is still complaining. Though the hike was double the amount recommended by the commission’s own judges, it was less than half of what the company asked for.” He warns that if the company succeeds in getting itself deregulated when the Illinois Telecommunications Act comes up for review next spring, “the worst-case scenario for consumers is an unregulated SBC that can raise prices at will with little competition to keep them in check.”
Protecting the environment with sprawl? Writing in Environment (May), Harvard’s Richard T.T. Foreman notes that “the percent of hard-surface cover (due to roads, sidewalks, parking areas, driveways, and roofs) is a useful indicator of many environmental conditions in a built area. Planners consider overall stream quality and fish populations to be ‘good’ with 0-10 percent hard cover, ‘impacted’ with 10-30 percent, and ‘degraded’ with more than 30 percent.” As a rule, coverage above 30 percent occurs whenever residential house lots are smaller than a third of an acre.
By the numbers. Justina Wang writes in the June Chicago Reporter that the percentage of blacks and Latinos in Chicago’s population is 46. The percentage of these students at the city’s 10 largest universities is 23. The percentage of them at the city’s medical schools is 10.
The hype: Big drug companies need to make a lot of money to pay for the development of innovative drugs. The facts: From Dr. Marcia Angell of Harvard Medical School in the New York Review of Books (July 15): “Of the seventy-eight drugs approved by the FDA in 2002, only seventeen contained new active ingredients, and only seven of these were classified by the FDA as improvements over older drugs. The other seventy-one drugs approved that year were variations of old drugs or deemed no better than drugs already on the market. In other words, they were me-too drugs. Seven of seventy-eight is not much of a yield. Furthermore, of those seven, not one came from a major US drug company.”


Created: 05 September 2014
The school follows the NT DECS Special Education Policy – Provision for Students with Disabilities and Impairments in Northern Territory Schools in partnership with Student Services and parents. This partnership involves a balance of rights and responsibilities for all parties concerned ie. student, teacher, Student Services personnel, Special Education Support Assistant and parents.
Students with special needs are identified and assessed and will receive assistance relative to the level of their need. Students who require significant adjustments to the school and/or learning environment may go through the process of an Educational Adjustment Plan (EAP).
In all cases our aim is to maximise the success of each individual in our school community through a collaborative, inclusive approach. A Special Education Teacher provides a program to meet this aim.


Immunoassays are powerful techniques for understanding the role of specific components in complex systems. They work on the basis of the recognition of a specific component (target X) by an antibody or equivalent (affibody, RNA aptamer, recombinant antibody, etc.), which results in the production of a detectable signal. In most cases immunoassays are QUALITATIVE, providing information in terms of signal intensity. What is really wanted however, is a QUANTITATIVE assay providing information in absolute chemical terms, namely the concentration of target X.. Quantitative ImmunoAssays would allow:
- Detection of the absolute concentration of components
- Reduce inter-assay variation in data
- Permit successful statistical analysis of smaller sample sets
- Permits direct comparison of data generated at independent sites or occasions.
Quantitative ImmunoAssays are simple to construct. They require the simultaneous analysis of experimental (or test) samples and calibration standards. The signal intensity generated by calibration standards of known concentration permits conversion of the signals generated by the test samples into absolute units of concentration.
A calibration curve (or standard curve) establishes the relationship between the amount of material present and the signal intensity measured. In the case of immunoassays, this would represent the relationship between the epitope concentration and the signal intensity obtained. This relationship is often non-linear , and in many applications displays a dynamic range (or response range) of approximately two orders of magnitude in the concentration of target X.
To perform a Quantitative ImmunoAssay, a set of "calibration standards" containing the epitope in various concentrations are deployed in the immunoassay alongside experimental "test samples". Densitometry is performed on all data from the assay, and curve fitting used to define the relationship between epitope concentration and signal intensity. This mathematical relationship is then used to convert the signals generated by experimental samples into concentration of target X, which in our experience is highly accurate.
Molecular identity of Calibration standards: For Western Blot applications, a calibration standard is a molecule which contains the epitope feature of an immunoassay covalently bonded to a protein of known molecular weight. Two configurations of this structure are possible (Figure 1), where the epitope structure is either linked to the amino acid backbone (Fig 1a) in the form of a fusion protein or linked to a side chain of a specific amino acid (Fig 1b). Figure 1a and 1b: schematic representation of calibration standard molecules
Figure 1: Schematic representation of calibration standard molecules A set of calibration standards to common epitope tags (His6, c-myc, HA, FLAG, AU1, AU5, glu-glu, ) was analysed by SDS-PAGE/Western blotting (detected via the His6 tag). A single band of 55kDa was detected, and the intensity of signal decreased with decreasing calibration standard loading as expected (Figure 2). Figure 2: immunodetection of a serial dilution of His6-calibration standard
Figure 2: Immunodetection of a serial dilution of His6-calibration standard Densitometry of the data was performed and the data plotted to define the relationship between epitope amount and signal intensity (Figure 3). Mathematical fitting of the data was performed, with the best fit achieved by "one site-specific binding" analysis (GraphPad Prism) as shown in Figure 3. An excellent fit of the data was achieved using 6 calibration standard concentrations each analysed in quadruplicate. Similar excellent fits could also be achieved by analysis of fewer standards, with indistinguishable results obtained from 3 calibration standard samples analysed in triplicate. (Figure 3)
Figure 3: Mathematical description of a calibration curve To determine the epitope concentration of an experimental sample, the mathematical description of the calibration curve is rearranged to calculate epitope concentration from raw signal intensity. Figure 4 displays the quantitative measurement of three "test" samples. Test samples of 2pmol and 0.5 pmol were analysed and the results obtained were 2.153± 0.127 pmol (mean ± standard error, n=4), 0.552± 0.045 pmol (mean ± standard error, n=4), confirming the accuracy of the measure (Figure 4). Samples should only be analysed which fall within the calibration range, as errors are higher for observations beyond the confines of the calibration curve e.g. 0.125 pmol in this example. Figure 4: accuracy of Quantitative ImmunoAssays
Figure 4: Accuracy of Quantitative ImmunoAssays In summary, Quantitative ImmunoAssays are easy to construct and offer several valuable benefits to the researcher. They permit calculation of the absolute concentration of the component of study with high accuracy (error <10%) and high reproducibility. This enhances the quality of research results and also the productivity of research programs by facilitating the direct comparison of data obtained on separate occasions.


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Average salary a record $3.2 millionNEW YORK (AP) - Baseball's average salary increased 3.8 percent this year to a record $3.2 million.
According to final figures released by the Major League Baseball Players Association, the rise is the steepest since 2007. The boost was helped by an increase in the minimum salary from $414,000 to $480,000.
The New York Yankees had the highest average for the 14th consecutive season at $6.88 million.
The Los Angeles Dodgers rose from 13th to second at $5.55 million and Texas from 15th to fifth at $4.89 million.
At nearly $685,000 Houston had the lowest average since the 2006 Florida Marlins.
See other NationalSports news:Craig Sager Suffers Leukemia Recurrence
Alabama Dismisses DT Taylor
Mariners Prospect Passes Away After Boating Accident
Justin Verlander's 'Tight' Tricep Shows Improvement
Scoreboard Roundup - 3/29/15

domain: economics


One Enfield 2-Cell Ammo Pouch. Designed to be used with the P37 web gear, these pouches are in good to very good condition. Some discoloration on the brass fittings. These pouches are post-WWII Belgia..
Chinese SKS Chest Rig. These chest rigs have 10 pockets each, designed to hold loaded stripper clips of 7.62x39. These rigs are in good to very good condition. Materials and construction may vary slig..
Russian Mosin Nagant Unified Postwar Ammo Pouch. This pouch is visually similar to the rectangular SKS ammo pouch however it is for Mosin Nagant ammo. An internal divider on the inside separates the p..
One USGI Surplus 30rd M16 2-Magazine ACU MOLLE Pouch. Overall these pouches are in good to very good condition and may show signs of storage and/or use. Designed to hold two 30rd M16 magazines. Velcro..
One USGI Surplus 30rd M16 3-Magazine ACU MOLLE Shingle Pouch. These pouches are in very good to excellent condition and may show signs of use. These pouches are designed for 3 magazines and have molle..
West German Surplus Walther P38 / P1 Leather Flap Holster in used condition. West German manufactured for service with the P38 and newer P1 service arms. Quality leather construction with an integral ..


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domain: design


..."Privacy is the ability of an individual or group to control the flow of information about themselves and thereby reveal themselves selectively." says the good old Wikipedia. It's not been a good week for privacy as the personal details of millions of British citizens and their children go missing. Join a social network on the internet and you agree that they can and will collect data about you to "enhance your user experience." They will also collect data about you from third parties and broadcast your shopping habits to all and sundry. I was actually wondering whether I should post copies of my bank statements on my blog just to prove that I've nothing to hide, which in my case would quite literally be the case. Where will this all end? Is it perhaps not time to go offline and live an analogue life? Well the government has put pay to that illusion. You can't even claim child benefit without living in fear of your private details going lost. As Privacy International says, "criminals need to have only a basic level of information about an individual. They can then use resources such as public records or the Internet to fill in gaps. Social engineering tactics such as impersonation will then ensure that they can take over a person’s identity.”
“NI numbers, address data, date of birth and bank details are more than enough to nourish even the most incompetent criminal.”
There must surely be a growing mistrust of all kinds of electronic data storage and the uses, or rather misuses, to which it is being put. What about data protection? The very concept seems to be an illusion. Fast forward in time...The Gruaniad November 2017...Privacy shock as copy of entire national identity database is lost when junior civil servant loses mobile phone at Thanksgiving party in Amsterdam (known over there as the Cannabis Cup). When questioned by police the official said he had forgotten to send the details of the register to the National Audit Office before popping over for a naughty weekend in Dam. Far fetched? Remember that the records and bank details of 25 million people were on just two CDs! Recently I've had loads of spam claiming to be from banks with whom I never opened an account. I even get spam on Skype! Every day we lose a little bit more of our privacy one way or another and the increasing use of public and private partnerships means less, not more, security and protection of our data. A government that is so incompetent is not fit to govern.


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Nova landscape and design center
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Nova landscape and design center to open in Mission Viejo
Mission Viejo's image has shifted a bit in recent years, away from the suburban outpost whose reputation peaked about two decades ago. This month, however, the community gets a new kind of retailer to liven up the landscape, and — brace yourselves — it's all about food.
The dining destination, called Mission Viejo Kitchen, will be in a new shopping center, called Nova, designed by the team behind a small coastal town in nearby Laguna Beach and a Greenbrier golf resort in West Virginia.
The center will open in October and feature 50 shops, anchored by restaurants by Santa Maria's Bouchon chef Thomas Keller and New York chef Daniel Boulud. Its design was inspired by the work of French architect Jean Nouvel, who also designed a recent eco-friendly restaurant in the United Kingdom.
Dining will open Oct. 27 at the Boulud outpost, a Mediterranean-style restaurant at 1210Nova Center Drive, while Keller's flagship eatery will debut in early 2019.
These chefs represent two divergent methods of cooking — Boulud's extravagant approach relies on expert techniques that demand lots of space, resources and overhead, while Keller's recipe for success is crafted around simplicity and access to top-quality ingredients.
Dinner at both restaurants will be prepared under chef's skillets, or wood-fired pans that provide ample fuel to crank out many roasts and broils for large groups. As well, Boulud's more substantial restaurants in Manhattan and Paris use equally-massive ovens and work as small units, but Bouchon was designed with a smaller footprint in mind.
Boulud's résumé is filled with notable eateries in New York and his other restaurants in California, and a cookbook. Keller has two New York restaurants, one in Manhattan and one in New Orleans, and a California restaurant in Santa Barbara. His teams' dream is to open a restaurant that has Boulud's size and ambience but is inexpensive to operate.
Both restaurants have designed their buildings with distinctively Mission Viejo decor, Boulud with dark timbers and terra cotta tiles, and Keller with locally sourced furnishings and earth tones.
The restaurants will share space with a variety of casual eateries, including an oyster bar, upscale pizza place and a gastro pub.
"It's not that the food is any better than (their counterparts in) New York and L.A. It's that it's significantly cheaper," Boulud said.
Boulud once said about the food business, "We don't want to destroy our craft to be bigger than that."
As the names suggest, the location is inside the Sierra Mission Viejo shopping center, which features a mixture of upscale shopping and restaurants. Its planners, real estate developer Michael Ho of Newhall Properties, said that restaurants and shops will be evenly distributed among the 60,000-square-foot space.
"The restaurant scene in the neighborhood has been shifting," said Ho, adding that the store will be "chic and sophisticated," and not "mushy."
The center will have plenty of space to support retailers, who typically prefer smaller, neighborhood centers, according to Ho. He called it a "pretty strong" selection that features brands such as Ferragamo, Manolo Blahnik, Burberry and Anne Fontaine, among others.
The center, which is to open in early November, is a center of higher end retail for the neighborhood. The green, stylish corner of Mission Viejo, which has been expanding into more upscale dining and shopping recently, should attract more people and thrive as long as it provides nearby housing, Ho said.
The restaurant's decor was inspired by the space, he said.
"We don't really try to make a big deal about it," Ho said, noting the kitchen is in the middle of the restaurant and no special area will be dedicated for a dining room. "It really is two restaurants in one, two kitchens in one space."
Kevin Christian, vice president of marketing at Sonoran Restaurant Group, which operates Bouchon in New York and upscale bistro and oyster bar Boulud Bistrot in L.A., said it will take time to sink in for diners that have been accustomed to eating in these places, but the menu will reflect the restaurants. The cooking will be similar, but the L.A. version will be more casual, he said.
"You get that kind of'more-casual' experience, but you get the real, raw, quality ingredients that you know what you are paying for," he said.
Keller and Boulud both designed their places to look and feel like they're inside a house. While Keller's downtown Manhattan restaurant looks like the loft from "Sex and the City," Boulud's restaurant in Paris has a subway-station vibe, with a red-tiled, mustard-hued ceiling.
His restaurant, Boulud and the Skinny Table
What: Boulud's restaurant in Manhattan
Where: 20 West 16th St.
Time: Lunch, dinner
Cost: A prix-fixe menu can be had for $69 or $249
How: Start with oysters and champagne cocktails. Choose from dishes like cod, duck breast with prunes, sauerkraut-bacon, then finish with pumpkin flan with nutmeg or the banana crème brûlée
"I think that, more than any other signature restaurant in America, this will be the restaurant that people want to recreate in their houses," Boulud said.
The two restaurants will share space and can hold up to 120 guests, a generous amount. Diners can use Boulud's reservation system or be seated by kitchen line. Keller said that keeping dining rooms small will give each dining room "great personal attention," as he and his teams try to minimize the space between diners and waiters.
The menu will serve different dishes and will allow diners to

domain: food


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The clinical features of WS are varied and include T1DM, OA, progressive sensorineural deafness, DI, autonomic nervous system dysfunction and, ultimately, brainstem atrophy and premature death. Although the medical and family histories are vital for the diagnosis of WS, genetic testing is becoming increasingly important. The majority of WS cases are caused by WFS1 mutations. Wolframin, the protein encoded by WFS1, is predicted to have a hydrophobic central domain comprising 9 membrane-spanning segments connected to a hydrophilic N-terminal domain and a hydrophilic C-terminal tail .(2) Wolframin is a component of the ER, which carries out post-translational modification, folding and assembly of newly synthesized proteins such as insulin. WFS1 may play a role in the negative regulation of ER stress signaling, thereby inhibiting the apoptosis of cells (including pancreatic beta cells) in response to ER stress.(9)
Wolframin is abundantly expressed in the pancreas, brain, heart and muscle. N-glycosylation of wolframin is thought to affect its biogenesis and stability, and there are five predicted Asn-glycosylation sites at amino acid positions 28, 335, 500, 661 and 746 .(3) Hofmann et al. reported that the R629W mutation causes instability and rapid degradation of wolframin .(2) The proband in the present case report carried a compound heterozygous W666X and K705Ifs*7 mutation (Fig. 4), the latter of which is a frameshift mutation that completely changes the N-glycosylation site. Mutation analysis has indicated that individual amino acids in specific regions are critical for correct protein folding, with substitutions at these loci inducing major functional changes .(10) Thus, the amino acid mutations identified in the proband in this study may be critical for correct folding of wolframin.
Most mutations underlying WS are located in exon 8 of WFS1, which encodes the transmembrane region and C-terminal tail of wolframin. However, the same mutations in exon 8 can have heterogeneous clinical presentations. The patient in our study had a compound heterozygous mutation (c.2113_2114insT and c.1997G > A) and presented with three of the four components of DIDMOAD (DI, DM and OA) but not hearing impairment, which was reported previously for a patient with the c.1997G > A missense mutation.(11) Phenotype variation has also been described for another mutation (c.1346C > T, p.T4491): one affected patient showed urethral involvement and severe anorexia while her younger sister exhibited microalbuminuria without neurological or urinary tract involvement.(12) The c.1997G > A mutation identified in the proband described here causes premature termination at codon 666 and an incomplete hydrophilic C-terminal tail. Most mutations associated with deafness occur in exon 8, which contains the conserved C-terminal domain that seems vital to cochlea function.(13) The C-terminal may interact with other proteins, and its deletion may disrupt these interactions and protein function.(14) The patient in our study also had an nucleobase insertion at codon 705 that resulted in frameshift and rearrangement. This insertion mutation may be in a region that impacts on the interaction with other proteins, causing the phenotypic difference with regard to hearing impairment. However, it should be noted that WS in our patient could also have been due to an allelic variant in the promoter regulatory region in the intronic sequences of WFS1 or a mutation in a different gene that was not detected with the current technology.
The proband in this case report developed T1DM at the age of 2 years, DI in the first decade, OA, neurogenic bladder and urinary tract infections in the second decade, and neurological abnormalities later in life. Although clear genotype-phenotype correlations have yet to be characterized, it has been suggested that missense mutations have a relatively mild phenotype while inactivating mutations (deletions, insertions, nonsense mutations and splice site mutations) cause more severe disease .(15) This is supported by another study reporting that patients with WS caused by missense mutations in WFS1 had a mild phenotype.(16) Consistent with the above hypothesis, the patient in our study had a nonsense mutation and insertion in WFS1 and exhibited a severe phenotype, including the onset of DM at only 2 years of age. Inactivation of both WFS1 alleles is known to be associated with early-onset DM.(17) Interestingly, a study of juvenile-onset DM in Lebanon identified a particular WFS1 mutation encoding a protein with an extended C-terminal domain that resulted in a delayed onset or absence of extrapancreatic features.(18) In vitro and in vivo animal experiments have found that wolframin depletion causes a reduction in insulin content, impairment of glucose-stimulated insulin secretion and activation of apoptosis.(19) Interestingly, single nucleotide polymorphisms in WFS1 are strongly associated with DM risk in the general population.(20) Since the proband’s mother had a family history of T2DM, it will be interesting to determine whether the K705Ifs*7 mutation is associated with an increased risk of T2DM. Further research is needed to establish the association between WFS1 genotype and phenotype.
In summary, we have described a patient with WS likely caused by a novel compound heterozygous mutation in WFS1 (c.2113_2114insT and c.1997G > A). The patient developed DM at a very young age followed by DI and OA in the next decade and neurological abnormalities later in life. His severe phenotype may be related to the presence of inactivating (nonsense and frameshift) mutations in WFS1. Since genetic mutations tend to be population-specific, the identification of this novel mutation may help in future screening for carriers of WS.

domain: medical


text:
Radio Nasha - HT Smartcast
This story is about a village boy who falls in love with a girl who is candy crush queen, a fashionista and transforms himself for his love. Tune in to what happens next.
Share your email for exclusive updates
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domain: entertainment


NAKTO Electric Bike Foldable16 x 1.75 Tire Electric Bicycle with 350W Motor, 36V 10AH Removable Battery up to 19MPH, Throttle & Pedal Assist,Rear Disc Brake for Adults and Teenagers
Sale Sold out
Regular price $699.99 USD
Regular priceUnit price per
Color: 350W YELLOW
- 🚴【LONG RANGE BATTERY & POWERFUL MOTOR】— With Removable 36V10Ah battery, the Ebike allows riders to travel up to 40 miles per charge using pedal assist. 350w motor provides reliable support and 19mph top speed.
- 🚴【3 WORKING MODES】— Combining with 3 modes for your choose: Electric Bike, Pedal Assistant Bike and Traditional Bike; Enjoy your journey with this folding electric bike even during a traffic jam.The Max loading is 250lbs, suitable for 4'10''-5'10'' riders aged 12-60.
- 🚴【SAFE & COMFORTABLE RIDING】— 16-inch inflatable tires provide excellent ride stability and rear disc brakes provide strong brakes and protect your safety.Horns and bright LED headlights are equipped for safe night riding.Waterproof design, suitable for wet riding.
- 🚴【UPGRADE YOUR COMMUTING】— The height-adjustable seat gives you complete control over the comfort level of your adventure. Meanwhile, quick folding design makes it convenient to put into the car trunk, save more space for storage or transportation.
- 🚴【1 YEAR WARRANTY】— You are guaranteed with 1 year warranty for battery, charger, motor and controller. The electric bike comes 85% assembled so it's not hard for you to complete the rest. If there is any problem with the electric bike, please feel free to contact us.


text:
Enjoy some of the world’s best snorkeling in Maui, Hawaii’s pristine beaches. Recognized by readers of Conde Nast as the “Best Island” for seventeen years, Maui has amazing beaches particularly renowned for snorkeling.
Combine your taste for aquatic adventure and the convenience of upscale accommodations with a stay at the Wailea Beach Marriott Resort and Spa. Cradled against an oceanfront hillside, the 4-star hotel is located on the beach in Wailea, close to Mokapu Beach, Keawakapu Beach, and Wailea Beach.
Most flights to Maui arrive at the main Kahului (OGG) airport.
Maui is by far the most popular snorkeling island in Hawaii. The Wailea Beach Marriott Resort offers snorkeling activities at no additional cost.
Genuine adventurers should definitely take the opportunity to venture out on their own and explore Maui’s many world famous snorkeling beaches. The following ones should be on the list:
Honolua Bay: Located north of Kapalua, on the western coast of the island, it offers a great diversity of sea life. It’s designated as a Marine Life Conservation District.
Kapalua Bay: The best snorkeling can be experienced on the north side of the bay. The more experienced snorkelers can venture away from the calmer beach within the bay -- which tends to attract more family vacationers.
Maluaka Beach: The best snorkeling beach in Turtle Town Maui. Hidden behind the mountain of Haleakala, Maluaka Beach is protected from strong winds.
Ahihi Kinau Natural Reserve: A protected marine life oasis, the Ahihi Kinau Natural Reserve rests on a coast line that is mostly made up of lava rock intermixed with coral.
Book a trip to Maui
Click here to book a flight to Maui through CheapOAir
Click here to book a room at the Beach Marriott Resort and Spa
WHAT YOU'LL NEED
Head Barracuda Dive Mask and Snorkel Combo, $45
Cressi Palau Long Fin Snorkeling Set with Bag

domain: geography


The Portugieser Perpetual Calendar Tourbillon Boutique Edition Story
The Portugieser Perpetual Calendar Tourbillon unites two sophisticated Haute Horlogerie complications. The tourbillon, made of 82 individual parts, weighs only 0.635 grams. The "whirlwind" causes the balance wheel to rotate around its own axis, compensating for the effect of gravity on the oscillating system and increasing accuracy. Requiring no correction until 2100, the perpetual calendar automatically recognizes the different lengths of the months and leap years. The moon phase display is so precise that it will deviate by one day only after 577.5 years. The self-winding IWC-manufactured 51950 calibre boasts a power reserve of 7 days. The case is made of 18-carat Armor Gold®. Thanks to a modified microstructure, this material is significantly harder than traditional gold alloys. The blue dial, gold-plated hands and the 18-carat gold appliqués underscore the maritime character of this special edition, which is limited to 50 pieces and sold exclusively in IWC boutiques. The timepiece is fitted with a blue alligator leather strap.
Calibre Family 50000
The 50000-calibre family features the efficient Pellaton pawl-winding system with a 7-day power reserve and a Breguet spring for maximum precision.


text:
Welcome to World Jewish Heritage
Rediscover your heritage like never before
Tel Aviv White City
Tel Aviv White City
|Location Rothschild Boulevard|
|City Tel Aviv-Yafo|
|Open to visitors yes|
|Need appointment yes|
|Handicap accessibility yes|
|Geographical Coordinates 32.06545,34.77663|
The White City refers to a collection of over 4,000 Bauhaus or International style buildings built in Tel Aviv from the 1930's by German Jewish architects who immigrated to the British Mandate of Palestine after the rise of the Nazis. Tel Aviv has the largest number of buildings in this style of any city in the world. Preservation, documentation, and exhibitions have brought attention to Tel Aviv's collection of 1930's architecture.
In 2003, the United Nations Educational, Scientific and Cultural Organization (UNESCO) proclaimed Tel Aviv's White City a World Cultural Heritage site, as "an outstanding example of new town planning and architecture in the early 20th century." The citation recognized the unique adaptation of modern international architectural trends to the cultural, climatic, and local traditions of the city. The Bauhaus Center in Tel Aviv organizes regular architectural tours of the city.
The concept for a new garden city, to be called Tel Aviv, was developed on the sand dunes outside Jaffa in 1909. British urban planner Patrick Geddes, who had previously worked on town-planning in New Delhi, was commissioned by Tel Aviv's first mayor, Meir Dizengoff, to draw up a master plan for the new city. In addition to Geddes, and Dizengoff, the city engineer Ya'acov Ben-Sira contributed significantly to the development and planning during his 1929 to 1951 tenure. Both the emigration of these Jewish architects and the closing of the Bauhaus school in Berlin were consequences of the rise to power of the Nazi party in Germany in 1933.
The residential and public buildings were designed by these architects, who took advantage of the absence of established architectural conventions to put the principles of modern architecture into practice. The Bauhaus principles, with their emphasis on functionality and inexpensive building materials, were perceived as ideal in Tel Aviv.
The architects fleeing Europe brought not only Bauhaus ideas but the architectural ideas of Le Corbusier were also mixed in. Furthermore, Erich Mendelsohn was not formally associated with the Bauhaus, though he had several projects in Israel in the 1930's as did Carl Rubin, an architect from Mendelsohn's office. In the 1930's in Tel Aviv, many architectural ideas were converging and Tel Aviv was the ideal place for them to be tested.
In 1984, in celebration of Tel Aviv's 75th year, an exhibition was held at the Tel Aviv Museum of Art entitled White City, International Style Architecture in Israel, Portrait of an Era. Some sources trace the origin of the term "White City" to this exhibition and its curator Michael Levin, some to the poet Nathan Alterman.
The 1984 exhibition traveled to New York, to the Jewish Museum. In 1994, a conference took place at the UNESCO headquarters, entitled World Conference on the International Style in Architecture. Credit was given to Israeli artist Dani Karavan who made a sculpture garden at the headquarters, and had earlier made a sculptural environment entitled Kikar Levana that was inspired by the White City. In 1996, Tel Aviv's White City was listed as a World Monuments Fund endangered site. In 2003, UNESCO named Tel Aviv a World Heritage Site for its treasure of modern architecture.
Bauhaus or International style buildings,


text:
19TH CENTURY ANTIQUE FIRE GUARD WITH NAPPY RAIL Ref:C89W
19th Century Antique Fire Guard with Nappy Rail
This is a lovely antique fire guard that is in very good, orignal and complete condition, all the wire work is intact. Dating from around 1860-70, this large antique spark guard has a polished brass top rail and with an additional, useful original brass nappy rail, great for drying small pieces.
Height: 77cm (30.31")
Width: 98cm (38.58")
Depth: 42cm (16.54")
S O L D

domain: hobby


text:
The Addams Family: A New Musical 10/29 – 11/7 tickets now on sale!
Don’t miss Broken Leg Theater’s first show at the Perkinson Center! BLT makes its debut on the Jimmy Dean Theater stage with The Addams Family: A New Musical!
When a grown up Wednesday Addams falls in love with a very “normal” Lucas Bieneke she decides it’s time to for her family to meet his. This comedic musical is fun for the entire family – whether yours is normal or…. not so normal.
The Addams Family features the characters we all know and love. This production is directed by Megan Livingston and features a cast of over 30 adults and children.
Adults $20, Children $13


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Maada Bio Held Development Policy Dialogue Forum
In his Acceptance Speech on October 15th, 2017, the 2018 Presidential Candidate of the Sierra Leone People’s Party, Rtd. Brigadier Julius Maada Bio appealed to other political parties for the 2018 elections to be a contest of ideas, policies and programmes and not personal attacks.
Showing leadership as the next President and wanting to focus the elections on the challenges the country faces, Rtd. Brigadier Julius Maada Bio on Saturday 18th November 2017 held a “Development Policy Dialogue Forum” at the Radisson Blu, Mammy Yoko Hotel, Aberdeen, Freetown. One of the objectives of the Development Dialogue Forum is to create a platform for the SLPP Presidential Candidate to share with donor partners, NGOs, CSOs and the press his views on critical development challenges in Sierra Leone and how he intends to address them.
In his presentation – “The New Direction: Policies to address Critical Development Challenges in Sierra Leone” – Rtd. Brigadier Julius Maada Bio highlighted the present development challenges in many areas of governance with figures and statistics showing a man who will be a very competent President.
On Marco-economy, Bio spoke about slow economic growth, fiscal gap between domestic revenue and expenditure, high inflation, external debt about $1.5 billion and domestic debt over Le 4 trillion and depreciation of the exchange rate. He spoke about other challenges in Agriculture Sector, Tourism, Marine Resources and the Private Sector.
On Human Development, the SLPP Presidential Candidate spoke about challenges in Education, Health, empowerment of youth and women, protection of children, protection of person with disabilities and aged and protection and empowerment of workers.
With his experience as former Head of State, Bio also used his presentation to highlight various challenges on improving governance dealing with building national cohesion, fighting corruption, revamping democratic institutions, building an effective parliament, strengthening local councils and chieftaincy, strengthening the civil service, advancing human rights and rule of law, promoting Press Freedom and developing the fourth estate, Foreign Relations and the security sector.
With APC using infrastructure as the centrepiece of their achievement, Bio also highlighted many challenges in Infrastructure dealing with access to electricity and water supply, improving transportation and improving information, communication and technology. He also spoke about access to land, housing for citizens and country planning and protecting the environment.
In all the challenges he highlighted from the various sectors, a confident, prepared and competent Rtd. Brigadier Julius Maada Bio also told his audience what the next SLPP government will do to address those challenges. One of the areas that received a loud ovation from the journalists was when Bio stated that in the next SLPP government there will be a yearly subvention to SLAJ from the budget.
As a candidate who is determined to build a national consensus on governance, Bio called on the stakeholders to bring forward their views on these critical development challenges and how they can be addressed as the Development Policy Dialogue Forum is part of the process of writing the Party’s Manifesto. It is expected that the SLPP Manifesto Committee, chaired by Rtd. Brigadier Julius Maada Bio, will also engage development partners on the details of specific thematic areas.
The ceremony was chaired by Jacod Jusu Saffa, Policy Advisor to Rtd. Brigadier Julius Maada Bio while the welcoming of stakeholders was done by the National Chairman and Leader, Dr. Prince Alex Harding. The closing Remarks was given by the National Secretary General, Umaru Napoleon Koroma and representatives of development partners, NGOs, CSOs and Press graced the Occasion. Also in attendance was the elegant wife of Rtd. Brigadier Bio, Fatima Bio and the National Campaign Chairman, Dr Alie Kabba among others.
In the next coming days and weeks, the SLPP information, Media and Communications Committee will also be serialising Rtd. Brigadier Julius Maada Bio’s presentation on social media to give the wider public the chance to know how the SLPP Presidential Candidate intends to address the critical Development Challenges with his policies as the next President of our great republic.
©SLPP Information, Media and Communications Committee

domain: politics


text:
Gwesty'r Marine Hotel
Travel Blogs from Aberystwyth
... cathedral we have a pot of tea with a few scones with jam and clotted cream, I feel very English looking out at the cathedral gardens and the castle we glimpse in the distance. We take a scenic road enroute to Aberystwyth and we see a man walking down the one lane road wearing only a speedo and a fishing hat. We burst out laughing after we pass him, thinking he seemed very out of place indeed. The sheep crossing the road and the distant sounds of bleeding ...
... made for a fantastic night not to remember. :) The next morning we drove to the big pit mining museum and went 300ft underground into the mine. It was absolutely terrible in my opinion. My anxiety was through the roof because 1. I despise elevators and these were about as terrifying as they get, 2. I despise small spaces, and 3. I despise being cold. At least once we were done with that, we went to a national park and were able to do some exploring. The John ...
Sunday morning and I was up with the lark. It was a rather late lark. I think my watch said 08:19. It was raining a bit but not enough to spoil the view and a few minutes after getting out of the shower the baguettes were in the oven and the bacon and sausages were ready for the frying pan. I seldom bother cooking a breakfast but it has become something of a tradition for us at the festival. I start everything off, the smell of bits of a pig being cooked drags Julie out of bed ...
... but last year one built high on a mountain north of Machynlleth was the winner. After some Curry Stall curry and Waen Brewery Chili Plum Porter we were whisked of by taxis with a promise that we would be back in time for the 17;30 Brian Gittins show.
The shed was properly high up with fabulous views over to Cadair Idris and the Aran Mountains and as we ascended the short path from the end of the road we were greeted by none other than Arthur Smith.
After a pause ...
... that when you’re leaving you’re probably at the back). Our next venue was my favourite, Y Tabernacl, where Arthur Smith was performing “ … sings Leonard Cohen Vol. 2”. It’s a few minutes across town (nowhere is very far from anywhere else in Machynlleth but we weren’t going to run!) and the small bar and foyer were full when we got there but nobody was going in. I think they were about 20 minutes late getting underway but ...
How has this hotel rated in the past?
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Historical Traveler Reviews Gwesty'r Marine Hotel Aberystwyth
After driving for 3 hours non-stop with my elderly mother I arrived at the Marine hotel only to find that the reception had been closed and no one around who could check us in. We'd paid for an evening meal which no one was prepared to serve us, only after a certain amount of complaining did some one attend to us and arrange for some food to be made up for us.
The standards of the rooms we had was not acceptable and for a top hotel of a sea side town the standards we're awful.
We'd paid for a christmas package and by the end of the weekend I felt I could get better service at McDonalds.
Warm and Friendly
We stayed at the Marine Hotel Sept 2004 and were pleased with the friendly welcome. The Hotel is in a great position and our room had a bay window with sea views. Although the room and bathroom were small, they were clean. The staff were very helpful and the buffet breakfast was very good.
The Marine Student Hall of Residence
Having been a student at Aberystwyth for many years I decided to return to the idyllic seaside town. Unfortunately my girlfriend and I decided to stay at the Marine Hotel. We were given a double room on the ground floor of an annex adjacent to the main hotel. For the extortionate price of £80 a night we had the pleasure of sharing a building housing numerous loud hen/stag parties. In addition, the decor resembled a poorly maintained student's halls of residence. Furthermore there was no light in the bathroom accompanied by no hot water. Whilst we couldn't find a phone in the room to complain we did discover a pair of safety goggles and gardening gloves beneath the bed!
Hotel staff were pleasant, seemed to care about their appearance and the appearance of their hotel. Went with a large group, stayed in a 5 bed room in the annex building a few doors down. The room was not made to our requirements, there was a bed unmade and a bed that had been slept in by a previous tenant! We were disgruntled to say the least, as we had been travelling all day. Never the less the bed was done asap and when we got back to the room it had been made up as we expected.
The room was cramped 3 single beds and a double in one place is a lot, especially for the price of the room, we expected something bigger. You could hardly move between the beds - buks would have been a better option. Wasn't keen that a pair of us had to share a bed, we don't know each other that well and it was a little awkward, ended up sleeping on the floor!
On the positive side the hotel was in an excellent position and a wonderful view - the bar's open till 3am!
The breakfast in the morning was definitly worth getting up for- the amount of food was fantastic, as it was self service there was nothing on the plate that you didn't like!
i would recommend staying the in main hotel as it seemed of much better quality, and smaller parties per room would also be a good idea, no more than 3!
All in all made a good weekend!
Fantastic Family Hotel very warm welcome
Had a wonderfull stay with my friends in the marine was visiting family and friends in the Aberystwyth area, fantastic rates. Food Fantastic especially the sunday Lunch. Would recommend to friends and family.
Me and my wife came had a wonderful stay at the Marine Hotel. The staff, food, bedroom and facilities were excellent. We will certainly return.
Cold comfort hotel
On a cold winter's evening, this place was particularly cheerless. The seafront sash windows didn't shut properly so the curtains flapped in the icy wind - which may explain why they were hanging off their runners. The plaster was falling off the ceiling. The bed was narrow.
The restaurant was closed. For £50 I expected something rather better.
Best breakfast in wales!!
we stayed at The Marine last month and had a wonderful stay, we had a beautiful four poster room with a stunning sea view. The breakfast is worth staying for in itself - full english buffet with plenty of choice especially for my husband who is vegetarian.
Marine Hotel Aberystwyth, Wales HORRIBLE!!
Stayed at the Marine Hotel in early Sept. We had been offered a 2 bedroom suite sharing one bath for my husband, mother, and myself. The bedroom for my mother had 2 beds that swayed back and forth. The main room had a king bed, but on a slope. My husband held on to one side, and I kept my foot on the floor all night. There was a twin bed at the foot of the King, a loveseat, armoire, t.v. cabinet, table and 2 chairs all crammed in the room. It was dirty,,,blonde hair all over the oveseat... carpet tiles coming up in the bathroom. This is certainly not what their web site advetises.

domain: travel


text:
Daily queues a source of national embarrassment
The Green Party has today stated its support for a campaign to reform the Garda National Immigration Bureau (GNIB) service, as the farce of people queuing all night for simple administrative documents worsens. The Party’s representative for Pembroke-South Dock, Cllr Claire Byrne, has said that the current situation is quickly becoming a source of national embarrassment.
Speaking today, Cllr Byrne said: “The nightly queues stretched around Burgh Quay are a national embarrassment, and I’m calling on the Garda National Immigration Bureau to find a solution to this problem. It is unacceptable that people are forced to queue up outside in the cold for twelve hours or more due to a lack of effort on the part of authorities to reform the system.
“There are pregnant women, mothers and fathers with their babies, children and old people waiting on the streets for hours in the cold. It is degrading and humiliating, and the level of inaction on this issue is unforgivable.
“The proposal to create an online appointment system is common sense one and there is no reason it couldn’t be implemented quickly and securely. The weather is rapidly deteriorating and we can’t wait until someone has an accident before something is done.”


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Despite the overwhelming challenges faced by its members and descendants over nearly 200 years, the MBCI continues to cultivate their heritage, freedom and self-determination.
USDA invited A-dae Romero-Briones, member of the National Organic Standards Board (NOSB), to be a guest author for this blog. The NOSB provides critical support to the USDA and the organic community. We thank the NOSB for their commitment to the organic community, and the integrity of the organic label.
In 2012, members of the Mississippi Band of Choctaw Indians (MBCI) established Choctaw Fresh Produce to help overcome employment and health challenges on their reservation. Today, by creating jobs and producing healthy foods on tribal lands, Choctaw Fresh Produce is also helping empower and transform their tribal communities.
The MBCI is a Federally-recognized Indian tribe of approximately 10,000 members that reside in eight reservation communities on 35,000 acres of trust land across ten counties in east central Mississippi. The MBCI are the descendants of the Choctaw that refused to be removed from their ancestral lands and relocated to land in what is now Oklahoma. Prior to the mass relocations known as the Trails of Tears that began in 1830, the Choctaw were dedicated to agriculture, hunting, and trade over what is now most of Mississippi. Read more »
Visitors to USDA’s Farmers Market on Sept. 30, 2016, weren’t playing Pokemon. They were helping with a behavioral economics field study about food choices. (Ken Melton, USDA)
This post is part of the Science Tuesday feature series on the USDA blog. Check back each week as we showcase stories and news from USDA’s rich science and research portfolio.
What were visitors to USDA’s Farmers Market on Friday, Sept. 30, doing with the iPads they were holding? They certainly weren’t playing Pokemon Go! Instead, they were participating in a behavioral economics study about food choices.
The USDA Farmers Market, managed by USDA’s Agricultural Marketing Service (AMS) and located just steps from the National Mall in downtown Washington, D.C., is a “living laboratory” for farmers markets around the country. It’s also a great place to learn about the factors that influence customers’ buying decisions. Read more »
Agriculture Secretary Tom Vilsack, greets military veterans James Youngblood, Staff Sergeant, United States Army, Cari Bains, Staff Sergeant, United States Army, Charles Horton Sr., Master Sergeant, United States Air Force, Jeffrery Dezort, Corporal, United States Marine Corps, Paul Derdzinski, Staff Sergeant, United States Army and Anthony Williams, Sergeant First Class, United States Army comprising the inaugural cohort of the United States Department of Agriculture (USDA) Agricultural Commodity Grader Apprenticeship Program at the USDA in Washington, DC on Mon., Oct. 3, 2016. The program is a Department of Labor (DOL) Registered Apprenticeship providing technical training and professional development to prepare employees to serve American agriculture. After successfully completing the 12-month pilot program, the apprentices will have a nationally recognized Department of Labor Apprentice Accreditation and the skills and training for professional success. USDA Photo by Ken Melton.
Over the last eight years, we’ve seen an increase in the number of veterans turning to agriculture for their post-service career. While many choose farming and ranching, others seek employment in the agriculture industry as well as federal service. USDA employs more than 11,000 veterans, and we’re looking to increase that number through a new apprenticeship program.
The program, which is being launched this week by USDA’s Agricultural Marketing Service (AMS) in partnership with the Department of Labor (DOL) and the Department of Veterans Affairs (VA), is a registered national apprenticeship that will grow a pool of talent for USDA. Although it is open to anyone interested in a career in agriculture, we are especially proud that it offers America’s veterans one more way to join our ranks. Read more »
In 2012, FMPP supported the launch of Adelante Mujeres’s Sabor Color commercial kitchen project. This project focused on training small food producers and processors to develop culturally appropriate foods from local ingredients.
With sales of over $11 billion in 2014 and projected growth of 10 percent annually, local and regionally-produced food is the fastest growing sector of American agriculture. At USDA, we hear a lot from communities interested in strengthening the connection between farmers and consumers. That’s why we’re investing in projects across the country to help farm and food businesses tap into this growing market.
Yesterday, USDA announced more than $56 million in grants to support local and community food projects, including a program administered by my agency, the Agricultural Marketing Service (AMS). The Farmers Market and Local Food Promotion Program awarded over $26 million in competitive grants, divided equally between the Farmers Market Promotion Program (FMPP) and the Local Food Promotion Program (LFPP). Read more »
Cage-free hen and eggs. As the agricultural landscape evolves to meet consumer demand, USDA Market News ensures that emerging sectors—like the cage-free egg market—have the data they need to succeed. Photo courtesy of the Oregon State Department of Agriculture.
As the agricultural landscape evolves to meet consumer demand, USDA Market News works to ensure that emerging sectors have the unbiased, reliable data they need to succeed in the marketplace.
USDA Market News – administered by USDA’s Agricultural Marketing Service (AMS) – provides data that serves as the information lifeline for America’s agricultural economy. Everyone in the ag supply chain is accustomed to visiting Market News for items like current wholesale and retail prices for beef cuts, but here at AMS we offer so much more. Read more »
Through LMR, more than a million livestock producers, hundreds of meat processors, some 37,000 retail food outlets, more than 1 million restaurants, as well as meat exporters, and many other stakeholders received critical data and market intelligence on a daily basis.
The Livestock Mandatory Price Reporting (LMR) Program was created to expand pricing information available to the livestock industry. The data is collected and distributed by USDA’s Agricultural Marketing Service (AMS) through its USDA Market News division to provide market information for cattle, swine, lamb, and livestock products.
LMR encourages competition in the marketplace by vastly improving price and supply data, bringing transparency, breadth and depth to market reporting. Through LMR, livestock producers and processors, retail food outlets, restaurants, exporters, and many other stakeholders receive critical market intelligence on a daily basis. Literally thousands of business transactions every day rest on the outcome of LMR data. Read more »


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Taiwan Chinsan Electronic Industrial Co Ltd operates within the Electronic capacitors sector.
In addition to historical fundamental analyses, the complete report available to purchase compares Taiwan Chinsan Electronic Industrial Co Ltd with three other
companies in this sector in TAIWAN :
Apaq Technology Co Ltd
sales of 2.00 billion Taiwanese Dollars [US$70.02 million]
of which 89%
was Winding conductive),
Hua Jung Components Co.,Ltd.
(765.06 million Taiwanese Dollars [US$26.75 million]
Kaimei Electronic Corp
(4.55 billion Taiwanese Dollars [US$158.97 million]
of which 53%
During the year ended December of 2019, sales at
Taiwan Chinsan Electronic Industrial Co Ltd were 3.73 billion Taiwanese Dollars (US$130.33 million).
decrease of 0.6%
versus 2018, when the company's sales were 3.75 billion Taiwanese Dollars .
Contributing to the drop in overall sales was the 3.1% decline
in Solid State Electrolytic Capacitor, from 714.01 million Taiwanese Dollars to 691.92 million Taiwanese Dollars .
There were also decreases in sales in
Liquid Electrolytic Capacitor (down 0.0% to 3.04 billion Taiwanese Dollars )

domain: finance


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Good Grief!: A Study of the Effect of Treating Addiction-Related Grief and Loss on Recovery from Substance Use Disorders
MetadataShow full item record
ABSTRACT Individuals who suffer from Substance Use Disorders (SUD) experience much loss while in active addiction (Shallcross, 2011). When the individual with SUD enters into recovery, he or she often experiences a host of emotions regarding the losses he or she has been through. This is said in the literature to be a form of grief (Kellerman, 1977; McGovern 1983, Denny & Lee, 1991; Moss, 2005). This dissertation examined the effect that a model of treating addiction-related grief had on elements of an individual’s recovery. The study herein is significant in that firstly, the name “addiction-related grief and loss” has not been coined in the literature to describe this phenomenon. Secondly, the study offered a seminal model of treatment for addiction-related grief and loss. Multivariate analysis of covariance and the appropriate follow up statistics were utilized to test the seven hypotheses outlined herein. An alpha level of .05 was used as the critical level for all tests.

domain: psychology


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The item was added to your waitlist!
Say hello to the Music To My Earrings. These pretty earrings go perfectly with the Nature Walk Top and would really dress up a solid colored tee! This gold earrings feature a semi-circle nature stone and have an approx 2" drop. One size fits all!


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Publication will be released at the end of May
Diane Cole Ahl, Arthur J. ’55 and Barbara S. Rothkopf Professor of Art History, has recently published her latest book detailing the life and work of the esteemed fifteenth century Italian painter, Fra Angelico. Her book, Fra Angelico, was published in April by Phaidon Press Inc. in London and will be released at the end of May. It is the third title in Phaidon’s new “Old Masters Series.”
“The book epitomizes my approach to visual culture, which is highly contextual,” Ahl explains. “It encompasses history, literature, religion, and the organization and economics of an artist’s workshop. I also consider the technique, condition, and preservation of art. This is directly relevant to Angelico, whose works have been transformed through restoration.”
The book displays 166 illustrations of Angelico’s works, almost all of which are in color. Lew Minter, director of the art department’s media lab, provided digital reconstructions of several of Angelico’s altarpieces. Art graduates Emily Gillespie ’07 and Kelly Murray ’06 helped Minter with the reconstructions.
The considerable amount of research required for this publication has taken Ahl across the United States and throughout Italy, England, France, Germany, Holland, Spain, and Russia, where she performed onsite research visits to churches, museums, and private collections. While in Italy, she conducted extensive archival, bibliographic, and onsite research, which involved discussions on Angelico’s technique with conservators who were restoring his paintings.
As with all of her research, Ahl believes that this project has and will continue to enhance her teaching in the classroom.
“The book considers not only Angelico, but central Italian art and architecture in the early Renaissance, areas that I teach in Italian Renaissance Art and Introduction to Art History II,” Ahl says.
Using her contextual approach to visual culture and drawing from Angelico’s spiritual and scholarly devotion, Ahl attempts to place Angelico within the “historical and devotional” context of Renaissance Italy.
“Angelico was a friar of the Dominican Order, which was devoted to preaching and scholarship. I identify specific theological texts, beliefs, and practices that illuminate the meaning of his works,” Ahl says. “I consider his technique, style, and innovations as a painter. These include his invention of a new type of altarpiece and experiments with perspective, landscape, and narrative.”
Perri Lee Roberts, senior associate dean at the University of Miami in Coral Gables, Fla., and a well-known scholar of Renaissance art, calls the book, “erudite, eminently readable, insightful, and beautifully produced.”
Natalia Swiderska ’03, who graduated with an A.B. in international affairs and art, assisted Ahl as an EXCEL Scholar with the early stages of preparation and research for the project. Prior to this, Swiderska assisted Ahl with her previous publication, The Cambridge Companion to Masaccio (Cambridge University Press, 2002) through the EXCEL Scholars Program.


Here’s an early peek at a heavily camouflaged 2020 Ford Super Duty pickup truck caught while it was undergoing road testing outside Detroit.
Ford’s entrant in the heavy-duty pickup market will be the subject of some moderate styling and trim changes for 2020. It went though a complete redesign for the 2017 model year. Many of the changes will mimic the face-lift on current model 2018 F-150 trucks.
The more substantive changes will be mechanical. It seems likely that a new gasoline-fueled 7.0-liter V8 will supplant the current 6.2-liter V8. The current engine makes 385 horsepower and 430 pound-feet of torque. Expect the 7.0-liter V8, which will be built in a recently revamped plant in Windsor, Ontario, to surpass those numbers while also offering better overall fuel economy.
A 10-speed transmission for the 2020 Super Duty will likely help fulfill that goal. Ford currently offers a 10-speed automatic in its bestselling F-150 full-size pickup truck. A re-engineered 10-speed designed to handle additional torque is a logical addition to the 2020 Super Duty.
Equally likely is a revised and potentially larger displacement version of the 6.7-liter turbodiesel V8 engine popular in Super Duty models. Power should exceed the current 450 horsepower. Torque might leap over the 1,000 pound-foot mark. The current 6.7-liter turbodiesel makes 935 pound-feet of torque.
A revised turbodiesel engine might lag the introduction of the 2020 Ford Super Duty.
In appearance changes, the 2020 Super Duty will get a new, bolder grille and redesigned headlights. The truck’s rear end will have changes that will likely be in the same mold as the changes seen on the 2018 F-150, with revised taillights, tailgate and a new tailgate latch.
The altered Ford Super Duty will be released next year as a 2020 model.


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Pacific Asia Journal of the Association for Information Systems
It is evident that E-Technology (i.e. The Internet, social media… etc.) play a significant role in maintaining and supporting our digital society in various sectors from business, education, health and government and others. E-Technologies are now available worldwide for numerous numbers of universal users to increase collaboration, communication, interaction, creativity, critical thinking and problem solving in developing and developed countries. It is anticipated, and there is evidence gathering that E-technologies use will increase work performance, productivity, innovation, workers’ satisfaction, reduce cost and maintenance. On the other hand, adopting e-technologies will bring various negative aspects in relation to security, privacy, legal aspects and users’ frustration, as majorities of these e-technologies are still neglecting important aspects, i.e. Human Computer Interaction and usability. It is anticipated that these aspects will assist to improve the system functionality, which can be used efficiently, effectively and satisfactorily by universal users, including people with disability.
Issa, Tomayess; Isaias, Pedro Teixeira; and Kommers, Piet
"Guest Editors’ Introduction-Special Issue on Digital Society and E-Technologies,"
Pacific Asia Journal of the Association for Information Systems: Vol. 5:
3, Article 1.
Available at: https://aisel.aisnet.org/pajais/vol5/iss3/1

domain: literature


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"Making a mockery of a nation
A response to George Will’s Friday article
As a woman born here in Springfield with Native Hawaiian roots, this article proved how little seems to be known about the history of Hawaii and the overthrow of a great nation. I was shocked at the ignorance portrayed by George Will. While I am sure the facts given were accurate, they were given with no remembrance to the history or times. Yes, Hawaiians did vote for statehood in 1959. This was after a long annexation and a territorial bond had been formed between Hawaii and the United States. Having the right to vote for the people who make the laws that govern your lives always seems to be the better choice. This does not mean that natives had not been robbed of their lands, natural resources or identity. The overthrow of the Royal Hawaiian government was considered peaceful, but how peaceful is it really when U.S. ships with loaded canons aimed at the city of Honolulu fill a harbor? How peaceful is it when a queen is imprisoned for wanting to take control of HER country? This overthrow may have been peaceful, but only because of the care a great queen had for the lives of her people. She refused to let their blood be shed. Does this mean that natives today should not try to right the wrongs that had been done to their ancestors? I don’t think so. I take pride in the steps the native people of Hawaii have made to restore the honor of a great nation. Sadly yet understandably, many Americans do not know the history of the Hawaiian people beyond grass skirts, shaking hips and surfing but trust me there is much more to know. We are a people with a history that has been written by conquerors. Now we try to remind you of the native’s story. I suggest a historical fiction I recently read, “Shark Dialogue’s” by Kiana Davenport; it gives a beautiful view of a multicultural Hawaiian family while showing a very different side of a traditionally one-sided history. There is much more I found laughably ignorant in this article, but I will not try to inform you anymore about the history of a people so greatly misunderstood here. Rather I urge you to take the time to uncover the true Hawaii behind all the glamor of Waikiki and awe of erupting volcanoes.Kathryn Ku'ulei "


OSWIECIM, Poland (AP) — Survivors of the Auschwitz-Birkenau death camp gathered for commemorations marking the 75th anniversary of its liberation, returning to the place where they lost entire families and warning about the ominous growth of anti-Semitism and hatred in the world. In all, some 200 survivors of the camp were expected, many of them elderly Jews a nd non-Jews who have traveled from Israel, the United States, Australia, Peru, Russia, Slovenia and elsewhere. Many… Read at AP News
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| RESEARCH ARTICLE
|Year : 2013 | Volume
| Issue : 5 | Page : 508-512
Effects of nano and conventional Zinc Oxide on anxiety-like behavior in male rats
Mozhgan Torabi1, Mahnaz Kesmati1, Hooman Eshagh Harooni1, Hosein Najafzadeh Varzi2
1 Department of Biology, Shahid Chamran University, Ahvaz, Iran
2 Department of Pharmacology, Shahid Chamran University, Ahvaz, Iran
Objectives: Current drug therapies for psychological disorders, such as anxiety, are not as effective as expected, and it has been shown that zinc supplements, such as zinc oxide (ZnO), can influence anxiety. ZnO nanoparticles (ZnO NPs) are among the most used nanomaterials produced and applied in many products.
Materials and Methods: This study investigated the effects of ZnO NPs in comparison with conventional ZnO (cZnO) on anxiety-like behaviors. Adult male Wistar rats were divided into groups: Control (receiving saline 0.9%), ZnO NPs (5, 10, 20 mg/kg), and cZnO (5, 10, 20 mg/kg). All drugs were dispersed in saline 0.9%, and 30 minutes after intraperitoneal (i.p.) injection of drugs, elevated plus maze apparatus was used to evaluate anxiety.
Results: ZnO NPs (5 mg/kg) and cZnO (10 and 20 mg/kg) significantly increased the percentage of time spent in open arm (open arm time % OAT) compared with the control group (P < 0.05). This indicates the anxiolytic effect of such components; in addition, ZnO NPs (20 mg/kg) reduced locomotor activity (P < 0.05). Serum zinc concentration increased by both anxiolytic dose of components (from 1.75 ± 1.07 (mg/l) in control group to 5.31 ± 0.53 (mg/l) in ZnO NPs (5 mg/kg) and 10.38 ± 0.90 (mg/l) in cZnO (10 mg/kg) groups). Also, all doses increased serum pH (from 7.3 ± 0.05 in control group to 8.1 ± 0.05 in ZnO NPs (5 mg/kg) and 8.05 ± 0.01 in cZnO (10 mg/kg) groups and kept them constant after 24 hours.
Conclusion: Results indicate that the anxiolytic effect of ZnO NPs is much higher than its conventional form, but the introduction of ZnO NPs, as a new drug for treatment of anxiety disorder, needs further investigations.
Department of Biology, Shahid Chamran University, Ahvaz
Source of Support: Shahid Chamran University, Conflict of Interest: None
[FULL TEXT] [PDF]*


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16.5.2019 â€“ 29.5.2019 leakage, improves the condition of the nerves responsible for the erection and the tone of the perineum muscles involved in maintaining an erection. In addition, the supply of blood vessels to the pelvis and perineum is stimulated and fibrosis can be treated after traumas and operations.
Main disorders and physiotherapy About 20 per cent of men in Spain suffer from erectile dysfunction, and many will suffer with prostrate disorders. In these cases, physiotherapy supports drug treatment
Healthy sexuality in the autumn years raises the quality of life
Physiotherapists should generally contribute to people getting to know and feel their bodies better through lectures and courses on sex education for adults and self knowledge therapies. This enables many changes to be recognised in time and countered where necessary.
ISLAND CONNECTIONS 846
as well as surgical interventions, prostheses and injections, by strengthening the pelvic floor. These exercises also help with premature ejaculation, which affects around 30 per cent of Spaniards. Only about three to nine per cent of men worldwide suffer from Peyronie's disease. This
How can sexual disorders be countered through physiotherapeutic exercises? The experts answered this question during the three-day course
means a strong curvature of the erect penis due to a thickening of the tissue. Penetration can thus become impossible or very painful. With physiotherapy the problem can also be countered with pelvic floor exercises and the changing of one's own body perception and in the physio-
and psychotherapeutic behaviour patterns. For women, a decrease in libido and interest in sex is the first priority. If medical causes are excluded, physiotherapy can help by strengthening the pelvic floor muscles and the abdominal muscles and by correcting posture. About a
quarter of women of childbearing age most often have problems maintaining their state of arousal during intercourse or reaching orgasm during normal intercourse. Exercises to promote blood circulation and to strengthen the pelvic floor as well as the spinal cord nerve of the clitoris are physi-
otherapeutic approaches. In the case of pain disorders during or after penetration, which can occur to varying degrees, physiotherapy can supplement medical treatment with scar massages, high-frequency thermotherapy, breathing exercises, abdominal, postural and n electro stimulation.
Officially the largest foreign language newspaper in the Canary Islands


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- What state pension does a widow get?
- When a husband dies does the wife get his pension?
- Does a widow get more state pension?
- What happens if my husband dies before retirement?
- How do I claim my deceased husbands pension?
- How much of my husbands pension Am I entitled to?
- What happens to a pension when someone dies?
- How do you stop state pension when someone dies?
- What is a wife entitled to when husband dies?
- What happens to my state pension if I die before 65?
- What is the maximum state pension 2020?
- What happens to my husbands pension when he dies?
- Who is entitled to a deceased person’s pension?
What state pension does a widow get?
If you were 45 when your spouse died you will receive £35.97 a week.
The rate goes up depending on how old you were when your partner died until the age of 55.
If you were 55 years old when they died, you receive £111.90 a week.
This rate continues until you reach State Pension age..
When a husband dies does the wife get his pension?
In some cases, a spouse dies while still employed, with that pension serving as a promise for a retirement that will never come. When that happens, the surviving spouse will be issued those benefits, either as a lump sum or as a bridge pension that ends when your husband would have reached his 65th birthday.
Does a widow get more state pension?
Inheriting or increasing State Pension from a spouse or civil partner. You might be able to inherit an extra payment on top of your new State Pension if you’re widowed. You will not be able to inherit anything if you remarry or form a new civil partnership before you reach State Pension age.
What happens if my husband dies before retirement?
If My Spouse Dies, Can I Collect Their Social Security Benefits? … A surviving spouse can collect 100 percent of the late spouse’s benefit if the survivor has reached full retirement age, but the amount will be lower if the deceased spouse claimed benefits before he or she reached full retirement age.
How do I claim my deceased husbands pension?
The spouse may inform the Bank of death of the pensioner and request the bank for commencement of family pension, through a simple letter. He/she may enclose a copy of death certificate of pensioner, PPO, proof of his/her own age/date of birth and an undertaking for recovery of excess payment.
How much of my husbands pension Am I entitled to?
You ought to get half the worth of your husband’s pension as a part of your divorce, but it will depend upon the factors named above and the way you choose to separate your marital assets on what quantity you receive and whether you receive a share of the pension or just assets up to the value of the pension.
What happens to a pension when someone dies?
If you are a member of an occupational pension scheme through your employer, and you die while you are still working, your estate will be entitled to a “surrender value” of your pension, which means the value of both the employer and employee contributions made to the policy.
How do you stop state pension when someone dies?
If the person was receiving a State Pension when they died, you should tell the Pension Service as soon as possible that they have died, so they can stop paying the pension. You can contact the Pension Service on 0800 731 0469 – ask for the Bereavement Service when you call.
What is a wife entitled to when husband dies?
If you leave behind a spouse and you have no children from either your current or previous relationship, your spouse is entitled to the entirety of your estate (after any debts are settled) If you leave a spouse with whom you have children, the spouse is again entitled to the whole estate.
What happens to my state pension if I die before 65?
‘ If you die before pension age, there is no guaranteed pension money reserved for your dependants or any return of the National Insurance you have paid. … If you have a better contribution record than your spouse or civil partner, they may use your contributions to get a better State pension when they retire.
What is the maximum state pension 2020?
A single person in 2020/21 will get £134.25 a week of basic state pension, that’s £6,981 a year.
What happens to my husbands pension when he dies?
If the deceased hadn’t yet retired: most schemes will pay out a lump sum that is typically two or four times their salary. if the person who died was under age 75, this lump sum is tax-free. this type of pension usually also pays a taxable ‘survivor’s pension’ to the deceased’s spouse, civil partner or dependent child.
Who is entitled to a deceased person’s pension?
The deceased person may have been entitled to pension benefits from a private company, government agency, or union. Some pensions end at death, but many pensions provide for payments to a surviving spouse or dependent children. Survivors may be entitled to part of the payments the person would have received.


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Warhead Industries "BLACK" Custom CNC Brushless Motor for Airsoft AEG (Model: Long Shaft / 36,000 RPM)
Brushless AEG motor
7075 Aluminum high quality casing
Total custom in-runner design with maximum power and torque
High temperature resistant quality copper windings
High quality magnets
Internal ESC with over amp draw and low voltage cut off to protect the motor and battery
High Precision CNC design
High quality D-cut removable pinion gear for easy switch outs
Highly efficient, durable, and reliable. The constant contact of the brushes with the power terminals of a brushed motor is necessary for it to maintain its rotation. However, the friction that this creates means that a huge portion of the energy generated by the rotational motion is wasted as heat. Generally, the efficiency of brushed motors is limited within the range of 75% to 80%.
Brushed motors are notorious for having parts that get worn out after a while, requiring frequent dismantling and parts replacement. This is because the brushes of the commutator need to maintain almost constant contact with the terminals of the power source, even as the commutator rotates rapidly. When brushes get worn out and can no longer maintain contact, a brushed DC motor basically becomes useless.
This is less of a problem with brushless motors. In fact, there is essentially no contact between the rotor and stator of a brushless motor, so wear and tear are greatly reduced.
Longer life expectancy. The accelerated wear and tear due to constant contact of the brushes and the energy generated as heat means that brushed motors are expected to break down much sooner than brushless motors. It is generally not recommended to operate a brushed motors for longer than several minutes continuously. Without a chance to cool down, heat buildup in brushed motors can easily compromise the integrity of its coils or brushes. Although in brushless motors there is still some heat generation due to air friction, this is kept at a manageable level. Brushless motors can typically run from 30 minutes to an hour continuously with no problems.
Operating Voltage: 7.2v - 11.4v (2 to 3 cell lithium polymer battery) RPM: 25,000 RPM at 7.4v, 36,000 RPM at 11.1v Motor Type: Long Compatibility: For Airsoft AEGs that utilize a long type motor
Why use a brushless motor in your AEG? Brushless DC motors have no brushes to get worn out, they represent a huge leap forward in technology. Brushless output significantly higher efficiency and performance, and have a lower susceptibility to mechanical wear than their brushed counterparts.
Brushless motors offer several other advantages, including;
Higher torque to weight ratio
Increased torque per watt of power input (increased efficiency)
Increased reliability and lower maintenance requirements
Reduced operational and mechanical noise
Longer lifespan (no brush and commutator erosion)
Elimination of ionizing sparks from the commutator (ESD)
Near-elimination of electromagnetic interference (EMI)