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KOCHI: The departments of endocrinology and ophthalmology at the Amrita Institute of Medical Sciences (AIMS) will organise various programmes as part of observing the World Diabetes Day. An awareness class will be held on the campus of the Amrita Brahmasthanam at Kunnumpuram from 9.00 am to 4.00 pm on November 15. The class will be conducted by experts from the AIMS, and its topic will be ‘Diabetes and Related Eye Problems’.
Patients who are interested in participating may contact 0484-4001099, 9400998248 or 0484-4007396, and register their names before November 10. On the sidelines of the programme, a free medical check up will be conducted for persons suffering from diabetes-related eye problems at the ophthalmology department of the AIMS.
In addition, a camp for children suffering from type-1 diabetes, and a cycle rally will be held on November 16. On November 21, a quiz on diabetes, for high school students, will be conducted at Amrita Vidyalayam, Kunnumpuram. Also, a month-long exhibition on diabetes and an all-Kerala quiz for medical students will be held.


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Serenity, I walk in bliss.
Trees breeze-whisper, nothing amiss.
Soft ferns hushed, shimmer velvetly.
Moist, fresh forest scent, nature’s kiss.
Your lips come to mind. Ecstasy.
I walk in bliss. Serenity.
Shinrin-Yoku is Japanese for forest bathing: bathing in the forest atmosphere, taking in the forest through our senses.
Grace is hosting Meet-The-Bar Thursday at dVerse, the virtual pub for poets around the globe. She’s asked us to write a Sparrowlet, a poetry form invented by Kathrine Sparrow. Here’s the elements of a Sparrowlet:
1. stanzaic, written in any number of sixtains (6 line stanzas) I wrote 1 sixtain.
2. syllabic: each line must be 8 syllables each (Often written in iambic tetrameter – I didn’t!)
3. Line 1 and Line 6 of the stanza is written in 2 himistichs (I had to look this word up)
4. Rhymed, rhyme scheme is BbabaA.
5. The 2 halves of Line 1 are inverted and repeated as a refrain in Line 6. The lst line MUST be the EXACT SAME as line 1, just switched around. You cannot change any of the words. (Punctuation may be changed to accommodate the meaning.)
Luckily Grace included an example of a poem written in this form within her prompt. The example for me, was much easier to follow than the definition itself! Pub opens at 3 PM Boston time. Come join us to try this form — or just to see how others wrote with it!
Photo from a trip to see my niece in Ohio a number of years ago.

domain: literature


The Neue Klasse BMW 1500 made its official debut at the 1961 Frankfurt Auto Show, and it hit showrooms in October, 1962. U.S. list price, $3,350. Curb weight, 2,390 pounds.
Engineer and ex-race driver Alex von Falkenhausen was put in charge of engine development. He had to overcome corporate sentiment for an anemic 1.3-liter engine, and he had to fight hard for the "stretchable" 1.5-liter design based on a sturdy iron (not aluminum) engine block. The M10 featured a slightly over-square 82 mm X 71 mm bore and stroke, a single Solex carburetor and an 8.8:1 compression ratio. BMW reported 80 peak horsepower at 5,700 rpms and peak torque of 118Nm at 3,000. In its 1963 road test, Road & Track magazine clocked the 1500 running 0-60 in 15 seconds and knocking down a standing quarter mile in 19.6 seconds at 68.5 mph. Road & Track posted 90 bhp for the 1500, with top speed of 93 to 95 mph, hinting that BMW had underreported the engine's power.
The four-speed gearbox featured synchros for all forward gears, "Porsche-type," as R&T put it. The interior was spartan by modern standards, but allowed for seatbelts for all passengers. The dash included a speedometer/odometer and a combination instrument with fuel level and water temperature gauges and warning indicators for oil pressure, battery charging, and high beams. It had a 6-volt electrical system.
Wilhelm Hofmeister led the design team. The BMW design signature, the "Hofmeister kink," made its first appearance on the C pillar of the 1500. Eventually, another BMW interior element made its first appearance on the Neue Klasse, the hooded pod on the dashboard for instrumentation.
The steel monocoque chassis had a wheelbase of 2,550 mm, overall length of 4,500 mm, width of 1,710 mm, and height of 1450 mm. Curb weight was 1060 kg. While curb weight would vary somewhat by model, the basic dimensions were unchanged throughout the production run. Buyers could choose from six colors, including Florida (066), Manila (004), Turf (073), Chamonix (085), Guayana (584), and Macao (690). A BMW factory list of accompanying interior colors for 1962/63 has not been cataloged at BMW Archiv. According to BMW historian Andreas Harz, no information is officially available through BMW Archiv on NK interior color palettes prior to the 1969 model year.
BMW sold more 1500s in two years than a decade's worth of Baroque Angels and Isettas combined. The company literally could not meet demand for its new star. So the elegant but dated sedans and the bubble cars were retired and production line capacity dedicated to the Neue Klasse.


text:
Author(s): Fatma YA?AR EK?C?
The purpose of this research is examining prospective teachers' attitudes towards teaching profession in terms of various variables. The research was conducted in the “?li?kisel Tarama” model. The sample of the study is consisted of 136 prospective teachers that study in pedagojical formation program at ?stanbul Sabahattin Zaim University. The tool that are used for data collection were “Personal Information Form” and “Scale of Attitudes toward Teaching Profession” that are developed by Üstüner (2006). In the analysis of the data, SPSS package program was applied. At the end of the research, it is found that the attitudes of prospective teachers towards teaching profession did not differ significantly in terms of gender, type of university that are graduated and age. But, the attitudes of prospective teachers towards teaching profession showed a significant difference in terms of the reason for choosing teaching profession, the degree program that are graduated, marital status and perception of the teaching profession as a respectable profession.


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Counterfeit Sixties Show
Tickets: £14 & £16
Venue: Phoenix Theatre, Blyth
Box Office: 01670 367228
Date: 9th October 2015 - 7:30pm
Re-live the sounds of the swinging sixties, as Britain's No. 1 tribute show brings alive the magic of the sixties, with their tribute to over twenty five bands of that era. The show encompasses everything from that period, from the clothes that were worn, to flashbacks from television history, including: TV programmes, adverts and even clips from the original bands.
The Counterfeit Sixties presents a showcase of the great bands of this unforgettable time. The fantastic music of The Beatles, The Rolling Stones, The Who, The Dave Clark Five, The Kinks and The Monkees - to name but a few - all recreated in this stunning show.
The band members have performed their unique tribute shows all over the UK and abroad, and have a wide range of experience in that field. The members of the band have individually worked with notable sixties’ artists such as The Searchers, The Ivy League, The Fortunes, The Tremeloes and many more.
Join us for a night of sixties nostalgia!
Newcastle Singing Contest - Open Mic UK 2015
Singing contest auditions are coming to Newcastle. Auditions for the exciting singing contest in Newcastle, Open Mic UK, are coming this summer! The Newcastle singing contest is brought to you by Future Music who are responsible for bringing us acts such as Birdy, Jacob Banks, Lucy Spraggan, Jahmene Douglas and Luke Friend.
TO ENTER THE NEWCASTLE SINGING CONTEST, GO TO: www.openmicuk.co.uk The Newcastle singing contest for Open Mic UK will be looking to find the UK’s best singer, duo, vocal group or rapper to be crowned the Best On The Mic 2015! The auditions for the singing contest in Newcastle are already anticipated to attract over 9,000 entrants this year, and now is the time to enter!
Whether you’re into pop, RnB, acoustic or classical, the Newcastle singing contest is ready to find the greatest undiscovered talent from across the country. The Open Mic UK Newcastle singing contest provides a platform to help acts get noticed and offers winners the potential to be successfully launched in the UK as a major recording artist.
The Newcastle singing contest Open Mic UK is open to anyone. Audition slots for the Newcastle singing contest are available across the UK, so if you’re a singer, duo, vocal group or rapper and think you’ve got what it takes, enter Open Mic UK now!
FOR MORE INFORMATION ON THE NEWCASTLE SINGING CONTENT AND TO ENTER, GO TO: www.openmicuk.co.uk
200ft TALL SHIP STAVROS S NIARCHOS TO VISIT BLYTH
AHEAD OF THE 2016 NORTH SEA TALL SHIPS REGATTA
The Tall Ships Youth Trust is excited to announce that Stavros S Niarchos will be visiting Blyth and hosting an open day for the public.
She will be arriving at the port of Blyth with 40 students from Emmanuel Schools on board following their 10 night voyage from Southampton.
The 200ft brig is the biggest to be built in the UK in a century and the open day will provide the public with the opportunity to go on board, explore her magnificent decks and learn more about a modern day square rigged brig.
Open Ship, Saturday 27th June, 12-5pm
The Tall Ships Youth Trust will be hosting a sponsored rig climb in the morning (10am-12pm) prior to the open day. If you would like the opportunity to go up and over on board Stavros, please contact Mike Bloomfield (email@example.com) for more information. Limited spaces available.
If you’ve always wanted to sail a Tall Ship, the 5 night Taster voyage taking place after the Open Day is the perfect opportunity to get on board. Giving you an insight to life at sea, this Taster Voyage will introduce you to the North Sea, with some fantastic coastline and a variety of wildlife to see. To book on, please visit the Tall Ships website.
SSN 708 – Tall Ship North East Taster
Sun 28 Jun - Fri 3 July
Holding an Event in Blyth?
Give us a call and we'll get it on here for you, or simply use the contact form below....

domain: artistic


text:
The Nature collection is a journey into the fascinating settings of the natural environment. The foundation here are trendily-styled base tiles with a fine and eye-catching pattern which captivates with its natural texture. The woodgrain of the tiles helps build indoor designs full of positive energy that ensures a proper recreation after a demanding day.
The palette of gentle natural tones, including white, green and brown, makes the perfect setting for decorative details which reinvent the decades of plant pattern design in ceramic tiles. The inserto tiles and the glass border tiles surprise with a play of lights which brings out the unique beauty of the indoor finish.


SANTA FE, N.M. (KRQE) – Companies are receiving big tax incentives to set up shop at Spaceport America including Virgin Galactic, but a pair of lawmakers want to make sure passengers flying to space are paying a tax on their $450,000 tickets. Right now, companies don’t have to pay gross receipts taxes for anything related to launching or operating space vehicles. The state put space passengers under that umbrella.
“The Taxation and Revenue Department determined that people were payloads,” said Representative Matthew McQueen. Now Rep. McQueen and Jason Harper say those tickets should be taxed. They’re both sponsoring House Bill 72. Rep. McQueen says while Virgin Galactic does benefit from some tax breaks, the bill clarifies to Tax and Revenue Department and Virgin Galactic, that tickets are not exempt from gross receipts tax.
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In Sierra County, where Spaceport America is located, the tax rate is 6.9%, with most of that going to the state. That means if the bill passes, and Virgin Galactic continues charging passengers $450,000, the tax for each ticket would be about $31,000.
“It is a recreational activity,” said Rep. McQueen. “If you buy a ticket for an event in New Mexico you pay a gross receipt tax,” McQueen explained. “If you buy a ticket for a ski lift, you pay a gross receipt tax. If you go to the movies, you pay gross receipts tax.”
As of November, Virgin Galactic reported about 700 people had put down payments on tickets, many of them at the previous price of $250,000. If the bill passes, anyone who has purchased their ticket in full before the law goes into effect, won’t have to pay taxes. Starting next year, Virgin Galactic is hoping to make three space flights each month. Each flight carries four passengers.


Everyone is Irish at a Flogging Molly show and the band proved why during a rousing, eighteen-song performance at The Pageant in St. Louis, along with Lucero and Matt Heckler.
Supporting their brand new album, Phantoms, out March 1st via 604 Records, Vancouver pop-rockers Marianas Trench hit Toronto’s Sony Centre for a ghostly good show, featuring support from Elijah Woods x Jamie Fine.
The weather was absolutely dreadful outside in Leeds but, inside Becketts University, Los Angeles alt-pop stars LANY brought some of their sunshine to a packed Yorkshire venue.
The Stranglers are back out on the road performing a selection of songs from their battered yet still utterly vital forty year catalogue of songs to a crowd who are as excited as they were first time around. Check out photos from their set here.
Belfast punks Stiff Little Fingers, kicked off their UK tour at O2 Academy in Leeds and showed that, even after 40 years, their punk rock mayhem is still as relevant as ever.
One OK Rock brought everyone into the ‘Eye Of The Storm’ with one of the most high-energy, captivating performances, featuring support from Waterparks and Stand Atlantic. Check out our review and photos!
Florida pop-rock band, Set It Off brought the North American leg of their world tour to Toronto’s Mod Club on March 6th for a rousing show, along with With Confidence, Super Whatevr and L.I.F.T..
Within Temptation and In Flames teamed up for an epic evening of music, fun, and birthday wishes on March 6th at Toronto’s Rebel nightclub.
The “Someone To Die For” tour brought Ours (Jimmy Gnecco) and Leeds (Royston Langdon of the well-known British band Spacehog) for their astounding singer/songwriter show through Toronto’s Horseshoe Tavern on March 4th.
In the last decade You Me At Six have come full circle from being an opening act to headlining a completely sold-out, jam-packed Gramercy Theater in NYC for a fun, inclusive night of music.
Albany pop-punkers State Champs brought their headlining North American tour to Toronto’s Phoenix Concert Theatre, with Our Last Night, The Dangerous Summer, and Grayscale tagging along.
Japanese rock band, One OK Rock, supporting their newest effort Eye Of The Storm, hit Toronto’s REBEL on February 28 along with Waterparks and Stand Atlantic... it was bound to be a hell of a night!
While making their way around the US on “The Truth Tour,” Nothing More came through Sacramento for an evening at the Ace of Spades with support from Of Mice & Men and Palisades.
Let’s be serious, it’s Robyn’s world and we’re all just out here paying rent in it. Touring for her most recent album, Honey, Robyn performed a sold-out show at Pacific Coliseum in Vancouver to close out February.
If you’re the type of band that consistently makes some of the most beautiful music, ever, it’s consummate to parallel its beauty in setting. While a specific venue to listen to alluring, Balkan-inspired indie-rock isn’t necessary, the Orpheum was as good a place as any for Beirut to deliver tunes off their sixth studio album, Gallipoli, out now via 4AD.
Last Wednesday night, amid a freezing rain downpour in Toronto, Corrosion Of Conformity, along with Crowbar, The Obsessed, and Mothership, played to an absolutely jam-packed crowd at The Opera House.
Enrapturing the The Opera House’s audience of Torontonians last Thursday, February 21st, The Neal Morse Band -- featuring Neal Morse, Mike Portnoy, Randy George, Eric Gillette, and Bill Hubauer -- delivered a dizzying display of exemplary prog.
Ahead of a busy 2019, Doncaster pop-rock quartet Bang Bang Romeo rock the life out of a packed local gig in Leeds. Check out the photos from the show here.
Chastity took to Toronto’s The Rec Room on February 15th, along with supporting bands Greys and Casper Skulls. Oh, did we mention there was a surprise three-song set from Alexisonfire?!
Injecting a little bit of Californian sunshine into the hearts of the Union Chapel audience, acoustic rock duo This Wild Life dazzled the London crowd, with formidable support from former Yellowcard vocalist William Ryan Key, and opener Rob Lynch.


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Sirius XM (SIRI) is already 0-for-1 hitting its growth targets, which CEO Mel Karmazin announced just late last year.
Last November, after the economy and auto industry started to unravel, Karmazin unveiled the satellite radio company’s long-term growth forecast. Part of that was getting to 19.1 million subscribers by the end of 2008.
That meant that in the last three months of the year — one of which had already passed by the time Sirius XM published its plans — it would need to sign up about 180,000 net new subscribers. (It started the quarter with 18.92 million subs.)
It didn’t even get half that many. Sirius XM signed up only 82,945 net subscribers during Q4, finishing the year with 19.0 million subs, about 100,000 short of its goal.
Makes you wonder if it’ll still be able to sign up 1.6 million subscribers this year, about the same amount as it signed up during 2008 (pro-forma). Or another 1.5 million in 2010.
On the plus side, Sirius XM posted a lower Q4 loss and beat Wall Street’s revenue expectations.
Sirius lost $248.5 million on $644 million of Q4 sales, better than the $405 million (pro-forma) loss on $558 million of sales during Q4 ’07. The Street had expected Sirius to report $616 million in Q4 sales, so it beat by about $28 million, or about 4%.
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domain: finance


text:
I read this article in the New York Times. Some interesting parts were:
Mr. Obama’s aides said they hoped to end the voting season with a delegate lead of more than 100, which they would seek to portray as a decisive affirmation by Democratic primary voters of Mr. Obama’s candidacy. Mrs. Clinton’s advisers said they were looking to bring the margin down significantly below 100 in hope of arguing that the result was too close for delegates to consider in deciding how to vote.
Mr. Obama’s campaign said that he had a lead of 1,139 to 1,003; by the count of the Clinton campaign organization, Mr. Obama was doing even better: 1,141 to 1,004 for Mrs. Clinton.
There are 1,082 delegates left to be selected.
By any measure, Mr. Obama is in a much stronger position on Wednesday than he was just a few days ago and in a significantly stronger position than Mrs. Clinton thought he would be at this point. That is because Mr. Obama not only won a series of states, but also won them by large margins — over 20 percentage points — so that he began picking up extra delegates and opening a lead on Mrs. Clinton.
And that is the problem for Mrs. Clinton going forward. If these were winner-take-all states, Mrs. Clinton could pick up 389 delegates in Texas and Ohio on March 4. Now she would have to beat Mr. Obama by more than 20 percentage points in order to pick up a majority of delegates in both states.
I think, speaking realistically, that this interpretation is probably true. If Obama ends up with a substantial (more than 100) won delegate lead at the end of the primary season it probably is only reasonable that he be made the nominee.
We can quibble about this or that (whether caucus states are less democratic than primaries, whether Florida votes should count, etc.) but the fact of the matter is that those were the rules of the game going in and the only thing less fair than those discrepancies would be changing the rules mid-game.
So while it is still my hope that Hillary can reduce Obama’s pledged delegate lead so that things are close enough that it would be reasonable to let the super-delegates decide based on other factors than just the raw delegate numbers, I accept that if she cannot reduce his pledged delegate lead to less than 100 that Obama should probably be made the nominee.

domain: news


text:
What is meant by the “Great Dying”?
The term ‘Great Dying’ refers to the planet’s biggest mass extinction of species that had wiped out most newly evolved lives in the oceans. It occurred around 252 million years ago and is also referred to as the Permian extinction.
It was caused by global warming that left ocean animals unable to breathe. Roughly 96 percent of marine species and 70 percent of land species went extinct.
What led to extinction?
A series of volcanic eruptions in central Siberia near the end of the era released massive amounts of greenhouse gases (GHG) into the atmosphere. The uncontrolled GHG emissions triggered climatic changes.
Earth is going through a similar phase of warming. Today, scientists from Stanford University warn of the imminent mass extinction of marine species similar to the Permian extinction that wiped out most lives in oceans.
The deep oceans are warming. The energy accumulated by the ocean is referred to as its heat content. In comparison to ocean water, which can hold 1000 times more heat, the atmosphere has a low heat capacity. As a result, the majority of the heat emitted by GHGs is absorbed by the ocean. In 2021, the heat content of the ocean reached a new high.
Recently, the UN (United Nations) Ocean Conference 2022 was held to ensure global cooperation toward protecting and sustaining the Ocean ecosystem in the world. Kenya and Portugal co-hosted it in Lisbon, Portugal.

domain: geography


text:
Atop Nob Hill, San Francisco, with its picturesque sights and a rich history dating back to the mid-1800s, you will find the flagship of the luxury, world-renowned Fairmont hotels, and resorts. The Fairmont San Francisco Hotel, where elegance meets excellence, proudly boasts panoramic views of the Bay. The hotel’s location is also the only place in the city where two of the iconic cable car lines intersect.
Boasting 600 rooms, the property is vast yet tastefully designed. The building decor, reminiscent of opulent days gone by, was impressive outside and inside. The hotel lobby featured grandiose hand carved ceilings, floor to ceiling marble pillars with scattered Asian inspired artifacts. Golden gilded velvet furniture, marble floors, and grand staircases continued the Asian theme, along with live orchids and potted bamboo trees.
The week we stayed, our fellow travelers were businessmen, solo travelers, and families wishing to experience luxury in the city by the Bay.
After driving six hours from LA, we finally arrived at the hotel in the late afternoon. The bellman greeted us warmly and helped us with our luggage through the check in process. Check in was a breeze since we had contacted the front desk personnel earlier that day to ensure that they had reserved a feather free and quiet room for us.
Much to our surprise, we were upgraded to the Nepal Suite.
I have to say that we were completely wowed! The Nepal was a corner suite with strategically placed windows showcasing the beautiful views of San Francisco. The large suite was divided into a living room, bedroom, and connecting mini hallway. The entrance hallway had a table with a mirror, stylish ceiling lights, and provided a functional welcome to guests entering the suite.
The Living Room
The designated living room was divided into two different areas. One was an elegant dining area, complete with a table that could accommodate half a dozen guests as well as a sitting area that had an opening sofa and two armchairs comfortable for reading the complimentary newspapers provided. The opening sofa turned out to be perfect for our son with autism, as it was spacious and facing the TV set that he enjoyed watching.
The room also had a rather large, elegant dresser/display case that stocked a surcharge minibar along with a coffee/tea station. The plush paisley designed carpet complimented the look of black, white, and brown furniture pieces in the room. We especially liked the San Francisco art photography displayed on the walls.
Our separate master bedroom was bright and airy, with plenty of natural light as well as bedside and standing lamps conveniently placed. Just like the living room area, the bedroom had its own TV set, which came in handy when we, the adults, wanted to watch a different program than our son. Needless to say, this suite had ample storage with a plethora of shelves, hanging space, and drawers. The walk in closet was so spacious that one could take a nap inside. The closet was probably the largest of its kind we had seen during our travels. In addition to the bed, there was a desk with an accompanying padded leather chair, which was useful for me as a writer.
We all appreciated that there were plenty of outlets to plug in devices in both rooms.
In sharp contrast to the generous size of the rest of the suite, the bathroom was relatively modest but beautifully designed. The floor was a golden-brown marble, and the sink was black granite. The bathroom had a combination bathtub/shower with a curtain and no handheld shower attachment, which would have been helpful for parents of younger kids. The amenity kit’s gently-fragranced Rose 31 cosmetics was an added welcome, as were the bathrobes and slippers supplied.
The attention to detail was impressive; even the toilet paper had a custom made fabric cover with the Fairmont logo stitched on it.
This hotel offered a choice of various dining venues. The first night we arrived, we enjoyed a scrumptious dinner at the Laurel Court restaurant along with a pianist for entertainment. The dining hall had a ceiling rotunda with gorgeous glass chandeliers and Italian frescos depicting countryside landscapes as decor.
The following morning, we enjoyed their breakfast buffet in the same hall with its lofty vaulted ceilings and grand marble pillars. The food was high quality and plentiful. The buffet featured different choices of juices as well as coffees and teas for refreshments.
The baked goods section had danishes, muffins, french toast, sticky buns, and bagels along with other pastries. The cut up fruit section looked especially inviting with its colorful fresh berries displayed. In addition, guests could feast on freshly made yogurts, a selection of cold cuts, cheeses, cereals, sausages, potatoes, and eggs benedict.
Our favorite was the chef’s station where you could customize your own omelet.
For those who need their java fix, the hotel had a coffee shop where they sell baked goods and hot beverages. The hotel’s stores also sold honey related products like beer and stuffed dolls.
Not to be missed was the hotel’s Tonga room, a fun place to go dancing and listen to music. The room served killer cocktails and scrumptious appetizers in a pirate ship environment.
The hotel rooftop is a popular venue for weddings and other special occasions, boasting manicured gardens overlooking the city. A less known area, albeit still interesting to explore with kids, is the hotel’s herb garden that supplies the venue’s kitchens with fresh ingredients. Complete with bee hives, raspberry vines, fragrant lavender and other herbs, visiting this little ecosystem below the clouds was one of the highlights of our stay.
We were very fortunate to get a private tour of the herb gardens and outside spaces with the hotel chef. During our chat, he elaborated on the hotel’s food menu for dogs. Apparently, the Fairmont in San Francisco is one of the few in the world that not only welcomes four-legged friends but provides freshly prepared food items that owners can order through room service or in the restaurant.
Room at this venue starts at $242 a night. The Fairmont has a parking garage, and the cost is $67 for valet parking and unlimited access per night.
Overall, the Fairmont San Francisco well exceeded our expectations, and we had an incredible stay in their hotel. The staff went out of their way to make us feel welcome as a family and to cater and accommodate our son with autism throughout our trip.
We look forward to staying at the beautiful property again sometime in the future.
Autism Travel Tips:
- Bring your own anti-slip mat for the bathroom if this is a concern.
- The hotel is very safety conscious, so the windows open partially just for air.
- The Tonga Room is a fun place. However, it can get crowded and noisy, and therefore might not be suitable for noise sensitive kids.
- For this size room, make sure you bring at least two night-lights. There’s quite a bit of walking in the dark, especially from the living room into the bathroom.
- If you do decide to go and visit the bees or get a tour, talk to your kid about not touching anything.
- There’s a lot of breakables in this suite. Ask staff to remove the breakables ahead of time if this would be a concern.

domain: design


The Chairman, Plateau Our Heritage, POH,Hon. Alex Kwapnoe has expressed the association sadness over the new wave of terror that has enveloped parts of the northern part of Plateau state.
Hon. Alex Kwapnoe made this disclosure in a press statement issued by Raymond Gukas in Jos says , that this is happening shortly after the Nigerian police force has alerted that Nigerians; especially from Plateau and neighbouring states to be on alert as the dreaded Boko Haram is regrouping is most unfortunate.
Where will the common man run to?; considering the anxiety associated with the late arrival of rain which has provoked the need for the rural farming populace to mobilise to farm?
As unfortunate as it is, the POH is further disturbed by the inaction of the state government since the police alert sounded.
The POH wants to categorically state that the issue has gone beyond a part of the state, but the entire state which must be protected going by the recent happenings.
While the body appreciates the state government’s efforts to tackle security issues in the past, the efforts are not enough to make the people sleep with both eyes closed.
The POH is throwing a challenge to the Rt. Hon. Simon Bako Lalong’s administration to change its approaches to these mundane issues or the state will stand to be restricted to the powers of these elements that are bent on sabotaging Plateau and her people and gain more territory for their nefarious actions.
We read the executive governor’s concerns over the killings in Jos and Riyom in particular, but we are asking that the governor’s words must be beyond frowning but must be matched with action if truly our rural inhabitants would have a stake in this year’s farming.
Please, our people must be protected; the stakes of insecurity are high.


Community development (31 - 40 of 198 items)
Community Development: Census Tracts With High Poverty Levels in Medium-Sized to Large Metropolitan Statistical Areas
RCED-99-246R: Published: Jul 28, 1999. Publicly Released: Aug 27, 1999.
Department of Energy Workforce Reduction: Community Assistance Can Be Better Targeted
RCED-99-135: Published: May 7, 1999. Publicly Released: Jun 7, 1999.
Environmental Protection: Agencies Have Made Progress in Implementing the Federal Brownfield Partnership Initiative
RCED-99-86: Published: Apr 9, 1999. Publicly Released: May 10, 1999.
Community Development: Extent of Federal Influence on 'Urban Sprawl' Is Unclear
RCED-99-87: Published: Apr 30, 1999. Publicly Released: Apr 30, 1999.
Community Development: Weak Management Controls Compromise Integrity of Four HUD Grant Programs
RCED-99-98: Published: Apr 27, 1999. Publicly Released: Apr 29, 1999.
Economic Development: Observations Regarding the Economic Development Administration's May 1998 Final Report on Its Public Works Program
RCED-99-11R: Published: Mar 23, 1999. Publicly Released: Mar 23, 1999.
Community Development: Progress on Economic Development Activities Varies Among the Empowerment Zones
RCED-99-29: Published: Nov 25, 1998. Publicly Released: Nov 25, 1998.
Community Development: A Survey of CDFI Organizations' Use of Performance Measurement
RCED-98-255: Published: Aug 25, 1998. Publicly Released: Aug 25, 1998.
Housing and Community Development Issue Area: Active Assignments
AA-98-19(3): Published: Aug 1, 1998. Publicly Released: Aug 1, 1998.
Community Development: CDFI Fund Can Improve Its Systems to Measure, Monitor, and Evaluate Awardees' Performance
RCED-98-225: Published: Jul 15, 1998. Publicly Released: Jul 15, 1998.


text:
I stayed at the property because it was selected by our group for their annual meeting.
The entrance was glamorous and very inviting. The rooms were nice with some decent views.
I felt for a Waldorf Astoria property that it was lacking in some areas. I think the hotel was just acquired by the Hilton group. The carpets in some places were stained. the maid service forgot to replace some of the amenities a couple of times..the shower door was leaking onto the floor..It just seemed that the hotel was not up to the Waldorf Standard...I would rate it as a Hilton or Marriott property, but not as a Waldorf.
- Official Description (provided by the hotel):
- The Waldorf Astoria Naples is Southwest Florida’s insider secret for couples, families and business groups looking for an eco-smart beach retreat with panoramic views of the Gulf of Mexico. Set on 23 waterfront acres adjoining a 200-acre nature preserve and mangrove estuary, the resort is celebrated for its genuinely friendly staff who embody the highly hospitable philosophy of "The answer is yes; what’s the question?" Inviting features include spacious guestrooms, suites and bungalows with private balconies or patios; same-floor meeting space and break-out rooms with floor-to-ceiling windows; energizing recreation, including championship golf, award-winning tennis and water sports on three miles of sugar sand beach; three signature pools, including one with a 100-foot water slide; a rejuvenating Waldorf Astoria Spa and inventive dining options. It’s also just a short stroll or bike ride on palm-lined streets to unique shops, restaurants and galleries. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Orbitz, Booking.com, Travelocity, Tingo, Expedia, Cheap Tickets, Despegar.com, BookingOdigeoWL, Priceline, Hotels.com and Venere so you can book your Waldorf Astoria Naples reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Waldorf Astoria Naples Hotel Naples
- The Waldorf Astoria Collection Naples

domain: travel


text:
The only thing better than an event at our bookstore here in Montreal with one lovely, talented author is an event with TWO lovely, talented authors. And in a few short weeks, before their books are *officially* available in stores, we are delighted to be doing just that - celebrating Pascal Girard's Petty Theft and Julie Delporte's Everywhere Antennas with a good old fashioned book launch. So mark your datebooks for Thursday May 15th at Librairie D+Q: we couldn't be more excited to welcome these two gifted cartoonists back to the bookstore. Pascal and Julie will be giving presentations, signing books, and meeting fans.
AND! Both books were just reviewed by the AV Club. Check it:
"Everywhere Antennas is… [a combination of the narrator's] penciled thoughts (done in beautiful, colored cursive writing) and her drawings and sketches… The story gains depth by tapping into larger social concepts like the refusal of modernity and an attraction to idealistic wishes for having a more simple life, if only for a brief period of time. Everywhere Antennas is fairly simple, but the way it leaves itself open to interpretation gives it its power."
"[In] Petty Theft, Pascal Girard offers up a dry, humorous, and neurotic look at his own dating life… The drawings are done in black and white… and their sketchy, stylized look fits well with the story. Much of the humor comes out in Pascal’s actions, which range from slapstick to irony, and while he and the woman of his dreams may not be made for each other, they make a good graphic novel team."
Now really, how good do these books look together?
All this (and some Good Times) can be yours, when...
Thursday May 15th at 7 pm
Librairie Drawn & Quarterly
211 Bernard O.


"Black Water" is a song by the American music group The Doobie Brothers from the album What Were Once Vices Are Now Habits. Released in 1974, it features its composer Patrick Simmons on lead vocals.
Simmons would credit his writing the song to making his first visit to New Orleans when the Doobie Brothers toured the southern states in the early 1970s. A lifelong aficionado of Delta blues, Simmons would state: "When I got down there [to New Orleans] it was everything I had hoped it would be ... The way of life and vibe really connected with me and the roots of my music." Having earlier constructed the song's basic guitar lick, he completed "Black Water" on the basis of the experience of his introduction to New Orleans: the lyrics Well if it rains, I don't care - Don't make no difference to me/Just take that street car that's goin' uptown specifically reference a streetcar journey Simmons made on a rainy day to the Garden District in Uptown New Orleans to do his laundry
More information on this artist is available in the last.fm tabs below.


- Education and Employment Readiness: Increase access and opportunities for children and adults of all ages in all demographic groups.
- Housing and Transportation: Secure more low income, affordable housing, and reduce homelessness; provide easy access to low-cost transportation so central Iowans can get to work and school.
- Change: Place Based, System and Individual Change: Develop an equitable approach to address poverty based upon need as determined by zip code; address policy issues such as the cliff effect, and develop a centralized intake/collaborative model for workforce. Encourage individuals to get to know and appreciate neighbors and other community members.
- Food Security: In food insecure households, access to food is limited by a lack of money or other resources. For families to thrive in our community, healthy and nutritious food needs to be accessible and affordable.


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Saturday, February 28, 2009
No Additional Cannabis Dispensaries the West Downtown Neighborhood
Posted by Christina P.
According to our records, Marijuana Dispensaries are springing up one on every corner. Currently, the West Downtown area is host to 4 cannabis dispensaries with more pending approval from the City of Santa Barbara. Although many patients utilize medicinal marijuana to aid chronic illness, many unauthorized "buyers" are flocking to these dispensaries each day. As a result, cannabis stations are now hubs loiterers and increased illegal activity.
Unfortunately, due to the high crime conditions in the West Downtown Neighborhood, we do not meet the requirements and guidelines set by the city of Santa Barbara to host additional dispensaries. However, in order to reduce and address the high crime activity, it is imperative to remove the West Downtown Neighborhood from the approved areas and thus preventing additional cannabis stations from emerging throughout West Downtown. As a result, Tony has drafted a petition to urge the City Council to remove the West Downtown Neighborhood from cannabis dispensary approved areas.

domain: sociology


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Back in March GameClub announced their intentions to the world, and our former Editor in Chief Eli Hodapp announced that he would be leaving TouchArcade after ten years and joining those efforts. What are those efforts you might be asking? Well, GameClub hopes to bring back many of the classic premium mobile games that have been lost to time over the past ten years, either due to compatibility problems with Apple’s hardware or software or due to a developer not having the means to continue maintaining the game for modern requirements. In just the two months or so since that announcement, GameClub has signed on more than 50 different games for their service, and by way of an Early Access program ran through Apple’s Testflight beta testing service players have been able to take some of these resurrected titles for an early spin.
A new title hits the Early Access program every week, and so far we’ve seen a return of such amazing mobile games as Hook Champ, Sword of Fargoal, Incoboto, Plunderland, and more. For those of us who were around when those games were new, being able to revisit them again is a shot of nostalgia and a reminder of just how many amazing experiences have graced the App Store over the years despite its terrible reputation from the larger gaming world of being filled with nothing but crap. More importantly is that a service like GameClub gives players who weren’t around for these titles a chance to experience them for the first time, and not only enjoy an excellent game but also see the historical value of these games that are by some of today’s biggest indie developers. For example, Rocketcat Games got super popular with Death Road to Canada, and it’s extremely awesome to be able to go back and see their roots with games like Hook Champ and Super Quickhook.
GameClub’s focus has been strictly on bringing back premium games, and they’ve received an overwhelmingly positive response since their unveiling to the world back in March, especially by those who know how many quality games have been on mobile over the years and by those who feel jaded by the free to play world that exists in the modern App Store. There’s really only been one huge question hanging over the whole thing: How will GameClub make money? Or more specifically, how will gamers pay for these resurrected titles? We now have an answer, as revealed by GameClub to FastCompany earlier today. GameClub will run on a subscription model similar to Apple’s own Apple Arcade service which is set to launch later this fall.
CEO of GameClub Dan Sherman thinks that the subscription model is “the next emerging trend in games" and that it “has the potential to be every bit as large as in-app purchases, or the ad market." While some people will instantly shun a subscription model right from the gate, I feel like that’s a bit of a myopic view. And hey, I get the notion of “subscription fatigue" as someone who subscribes to Netflix, HBO, Apple Music, Hulu, Twitch Prime, etc. I mean the last thing I’m ever looking to add to my life is another thing to subscribe to. But at the same time, at least with a subscription you KNOW what you’re paying upfront and you know what you’re getting in return. I can’t say the same thing about a freemium game, where it may or may not be “fair" and it’ll take you months of your life to even find out. More often than not a freemium game you get heavily into turns into a money pit whether you’re planning on it or not.
There’s another huge aspect to the subscription model though, and I think most people don’t tend to think about it: Sustainability. We live in a time where it’s just expected that games will receive updates after they launch. It’s great because if a nasty bug or ten sneak into a game, you’re not stuck with a physical version that can never be fixed. And of course that also means game experiences can grow by way of content updates, and it’s also pretty much expected that new content will be added to every game after it launches nowadays. The problem is that updates, whether bug fixing or adding content, cost time and money. A mobile game that sold for a one-time price of a dollar or two can’t be continually updated until the end of time. But that’s what they NEED in this day and age of frequent software and hardware updates.
So as much as many of us who grew up just buying a game for a fixed price might struggle with the notion of a subscription service, the model suits modern games. You’re not just subscribing to something like GameClub so you can play a library of old games, but you’re subscribing to create a sustainable revenue stream that ensures these games can remain updated and playable into the future, and that more and more new games can be added to the service down the road. Of course there’s also the elephant in the room that is Apple Arcade, another gaming subscription service launching this year. But I think, at least for the time being, GameClub and Apple Arcade are offering pretty different experiences. The former focuses on bringing back classics with modern updates, while the latter is focused on strictly brand new games. They should actually complement each other rather well.
Much like Apple Arcade, no pricing has been announced for the GameClub subscription service, but Sherman does go into several more details about the company in the article over on FastCompany, so definitely give that a read. I’d also love to know what you all think about subscription models and the direction of GameClub. Would you subscribe to it? Will you be subscribing to Apple Arcade? Would you subscribe to BOTH? Let us know your thoughts in the comments below.


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Illegal Cannabis Market Thrives As Legal Vacuum Stymies Legit Mainstream Players
As 2023 draws to a close, it’s become clear that the initial excitement around the legalization of cannabis has waned as Government has failed to put into place any meaningful policy since the historic Concourt ruling of 2018.
William Brederode, News 24
27 December 2023 at 10:00:00
This article first appeared on News 24 on 21 December 2023
Legal uncertainties have stymied the growth of the cannabis industry in South Africa, after an initial frenzy of interest and activity following the decriminalisation of the substance under certain conditions in 2018.
This is according to Rozayne Malyo, the co-founder of the Cannabis Development Council of South Africa who also heads up Think Green Consulting, a cannabis consulting organisation.
"[When] cannabis was decriminalised, there was a lot of excitement initially. A lot of people were interested, a lot of new businesses popped up and so on. But, in terms of the market, I think it has slowed down a little bit because there are a lot of grey areas still," Malyo said.
In 2018, a ruling by the Constitutional Court decriminalised the personal and private cultivation, possession and use of cannabis for adults.
There was a lot of optimism about the industry following this.
A 2019 report on the African cannabis industry produced by Prohibition Partners, an international cannabis business intelligence firm, estimated that the South African cannabis industry would be worth $1.85 billion (R34 billion) by 2023.
As Paul-Michael Keichel, a specialist attorney at Cullinan & Associates, said in a recent News24 article that "private grow clubs" started operating at this time, but authorities cracked down on them.
It is hoped that the Cannabis For Private Purposes Bill, which is currently before the National Council of Provinces, will bring some clarity for the industry if passed, Keichel said in the article.
For now, however, over five years after the Constitutional Court judgment, businesses in the sector still aren't sure how to run their operations legally.
Frank Rosen, the founder of cannabis products maker and retailer Canabliss, said the lack of clarity was "incredibly infuriating" for businesses and law enforcement officials alike.
He feels as though his company is "trading on the fringe" and desperately wants clarity on how he should be operating to comply with the law.
"Would legislation done properly be of value? Most definitely," he said.
Rosen is a proponent of the medicinal properties of cannabis. He says Canabliss has in-house medical professionals, including a physiotherapist, psychologist and, until very recently, a pharmacist.
"If I never sold another recreational product, it wouldn't worry me if I knew I could sell the medicinal side legally," he said.
A growing number of his clients think similarly, he claimed.
"Before, if you said 'I take cannabis for this', people would be like 'Oh my God. Pariah! He's a stoner. He's a drug addict.' Now, however, we are getting people of all ages coming to us."
Rosen added that he has clients aged from 30 to perhaps 95, who come to Canabliss for products to help with their various medical issues.
With the shifting user base, authorities are increasingly struggling to crack down on cannabis businesses and users.
Malyo said laws regulating the operations of cannabis businesses also seemed to be haphazardly applied.
"There are several things that are not clear in terms of cannabis shops because some people get arrested and then you find some other shops that are intact. We are trying to figure out what laws they are working on," she said.
Malyo also said the more restrictions there are for cannabis products, the more trade would be funnelled through the black market for cannabis.
"The black market is still thriving. It is thriving much more than [it would if cannabis products trade were] legal," she said.
Juicy Fields Saga Comes South: Private Russian Investigator Rescued From Rogue Police Extortion Web in Namibia
Afriplex, CRI, Releaf Take The Lead in Ground-Breaking Medical Trial That Proves Cannabis Is Safer Alternative Than Opioids In Chronic Pain Treatment
Afriplex emerging as the "go to guys" for all matters medical cannabis
Cannabis in South Africa: The People’s Plant
We are a civil society organisation with the interests of the existing Cannabis industry and the Human Rights of ALL citizens at heart.
Resources & Equipment
Explore cannabis growing equipment for growing weed at home.
Whether you’re just starting out, or you’re looking to enhance your outdoor or indoor weed grow setup – we have the perfect range of cannabis growing equipment to match your marijuana growing ambitions.
Find everything from LED grow lights, grow tents, fans, and hydroponic setups, to environmental equipment and controls, harvesting accessories, extraction equipment and plenty more.
Design your ideal cannabis growing setup with high quality growing equipment available in South Africa.
Explore cannabis growing equipment we’ve curated from reliable online suppliers in South Africa

domain: law


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Low Carb Coconut Shrimp Stir-Fry with Zucchini Noodles
Feel good about devouring this veggie-packed coconut shrimp stir fry, with ribbons of delicious low-carb zucchini noodles and tons of exotic flavour.
- Prep Time: 20 minutes
- Cook Time: 20 minutes
- Makes: 6 servings
All You Need
- 4 tsp (20 mL) extra virgin olive oil, divided
- 1 red bell pepper, sliced julienne
- 1 lb (500 g) shrimp, peeled and deveined
- 2 tbsp (30 mL) Simply Asia Sweet Ginger Garlic Seasoning
- Pinch each Club House Sea Salt Grinder and Club House Black Peppercorn Grinder
- 3 zucchini
- 2 green onions, finely chopped, plus more for garnish
- 1/4 tsp (1 mL) Club House Prepared Minced Garlic
- 1 tsp (5 mL) Club House Ground Ginger
- 4 tsp (20 mL) coconut sugar
- 1 can (400 mL) Thai Kitchen Lite Coconut Milk
- 1 tbsp (15 mL) cornstarch
- 1 tsp (5 mL) Thai Kitchen Fish Sauce
- Juice of 1 lime
- 2 cups (500 mL) Napa cabbage, shredded
- 1/2 cup (125 mL) frozen edamame
- 1 mango, sliced julienne
- Coconut shavings, toasted, to garnish
- Cilantro, to garnish
Heat 2 tsp (10 mL) oil in a large nonstick skillet over medium-high heat. Add the bell pepper and stir fry until slightly softened, about 2 minutes. Transfer the peppers to a dish and set aside.
Return the pan to high heat. Add in the shrimp, and sprinkle with 1 tbsp (15 mL) seasoning and a pinch of salt and pepper. Cook until pink and opaque, about 2 minutes per side. Transfer the shrimp to a plate and set aside.
Using a spiralizer, process the zucchini into thin strands. Cut some of the large pieces in half with kitchen scissors and set aside.
Return the large pan to medium heat and add remaining 2 tsp (10 mL) oil. Add the green onion, garlic, ginger and remaining 1 tbsp (15 mL) seasoning; cook for one minute or until fragrant. Add in the coconut sugar and stir until it melts and begins to lightly caramelize, about 2 minutes.
In a small bowl, mix a few tablespoons of the coconut milk with the cornstarch until the lumps disappear. Add remaining coconut milk, fish sauce, lime juice, and the cornstarch slurry to the pan. Heat on high until it comes to a boil, reduce heat to medium and simmer 5-6 minutes until thickened slightly.
Add in the zucchini, cabbage, edamame and toss to coat in the sauce. Add the cooked bell pepper, shrimp and the fresh mango to the stir-fry and stirring to warm through.
Serve topped with green onion, coconut shavings and cilantro, if desired.

domain: food


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$ 21.99 $ 45.00Size Guide
Gold plated multiple chain waist belt. Limited Availability.
Plating: 5kt Gold (1 gm)
Width: 0.25 Inch
Length: 24 Inches plus 12 Inch extension
Style Tip: Accentuate your waist with this waist belt. Can be worn over a dress or skirt as an exotic waist belt.
Style Personality: Ethnic Antique Chic: You surround yourself with antique things that transport you in that era. You love the charm of the antique things because they have a history behind it.
Ethnic Significance: "Kamarband" or Tagdi?, Waist Belt or Belly Chain is usually worn around the waist. The design differs from north to south India. The kamarband worn in North is mostly a chain with dangling ornaments, where as in south, it is like a broad belt in gold color. The brides wear kamarband to accentuate their waist.
Delicate silver tone anklet pair with soft bells. Limited availability. Metal: Alloy Length: 9.5 Inch Width: 0.5 Inch Clasp: 0.75 Inch S Hook Style Tip: Accentuates your ankles. Everyday to bridal wear....
$ 34.99Size Guide
Indian ethnic Pakistani gold plated set of 2 openable bangles in net filigree design. Limited availability. Metal: Alloy Plating: 5K (1gm) Gold Width: 1.25 Inch Clasp: Screw Barrel Style Tip: Very ethnic...
$ 17.99Size Guide
Ethnic Gold Plated Indian Pakistani payal Anklet pair with soft bells. Limited availability. Metal: Alloy Plating: 5K (1gm) Gold Length: 10 Inch Width: 0.25 Inch Clasp: 0.5 Inch S Hook Style...


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I know its overdue but there is a good reason why I’m only writing about ArtSource now! It was such hard work and to be honest it took some time to get back to my usual rhythm and routine. Also there was a couple of commissions that I had put on hold because of ArtSource, I just wanted to paint and not worrying about sharing online.
But there is few things I want to say albeit a week or so late!
First of all a big thank you to all my old and new fans that came in and said hi, that shared my posts online and wished me good luck. It can be a lonely place there at times so its always nice to see a friendly face. You guys are fantastic!
Also a big thank you to all that bought a painting, print or a card! I really appreciate it and I hope I added a little beauty to your lives and homes!
Also thank you to my fellow artists from the neighboring stands: Sylvia Linehan, fellow floral artist, John O’Sullivan with beautiful abstracts, Helen Lowe for giving us a few great tips and of course David Mc Glynn, I am still in awe of his amazing sculptures. Thanks to all for minding my stand on my breaks and for cheering on my sales!
For the first time I was able to offer prints of my originals which went down very well with the public. So many of you had asked me about prints over the last few years that I eventually decided to go down that route, it does make my art more affordable. So I launched them at ArtSource and it was a definite success. For anyone interested they will be available for purchase on my website soon (it all takes time!).
That’s my news for now but once again a big big thank you!

domain: hobby


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A team of researchers from McGill University in Canada has recently made a groundbreaking discovery related to a rare skeletal disorder known as spondyloepiphyseal dysplasia (SED). This disorder affects the structure and development of the bones and joints, causing problems such as short stature, limb deformities, joint pain, and heart defects.
It has been identified that the gene responsible for SED is known as matrix Gla protein (MGP), which is a protein that helps regulate calcium levels in the body. MGP is produced by certain cells in the skeleton, such as bone cells and cartilage cells. MGP can bind to calcium ions and prevent them from depositing in hard tissues, such as arteries and bones. This helps to maintain the health and function of these tissues.
In the course of their study, researchers examined four individuals from two families and pinpointed an altered MGP gene variant leading to abnormal bone development. Unlike normal MGP, this variant caused an abnormal protein, which, instead of leaving cells as usual, induced stress within the endoplasmic reticulum. This stress ultimately resulted in cartilage cell death and abnormal bone growth. Significantly, experiments on mice mirrored these bone problems, validating the findings.
The study also sheds light on the broader context of genetic disorders, specifically mentioning that variants in the MGP gene can lead to Keutel syndrome. Moreover, the researchers underscore the broader implications for public health, noting that more individuals with related conditions may seek medical consultation, contributing to ongoing research and clinical management.
SED is one of the many types of osteochondrodysplasia, which is a general term for a group of disorders that affect the development and growth of bones and cartilage. These disorders can cause various skeletal abnormalities, such as short stature, limb deformities, joint problems, and facial features. Osteochondro dysplasia can be inherited or acquired, and it can affect people of any age.
Some common types of osteochondrodysplasia are achondroplasia, pseudoachondroplasia, Legg-Calvé-Perthes disease, Crouzon syndrome, Marfan syndrome, Ehlers-Danlos syndrome, and mucopolysaccharidosis IV. These disorders have different genetic causes, clinical features, and prognoses.
The publication of this study has already garnered attention within the medical community, with clinicians identifying patients exhibiting the same MGP gene mutation reaching out to the research team. This collaborative effort, titled ‘Specific heterozygous variants in MGP lead to endoplasmic reticulum stress and cause spondyloepiphyseal dysplasia,’ involved researchers Monzur Murshed, Ophelie Gourgas, and their colleagues.
The researchers hope that their findings will help other people with similar skeletal problems to understand their condition better and seek appropriate medical care.
Download: Original Publication

domain: medical


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Bhadohi Nagar Palika: помешкання для відпочинку
Знаходьте та бронюйте унікальні помешкання на Airbnb
Найкращі помешкання для відпочинку в місті Bhadohi Nagar Palika
Гості погоджуються: ці помешкання мають високі оцінки за розташування, чистоту та інше.
Вілла · Devnathpur
Kaashi Flora Villa (Entire House)
A Stylish House in nature's lap away from the bustling city. The accommodation offers you a unique experience with modern stay amidst its rural roots. With gorgeous sunsets, access to mango yards, and the melodious chirping of birds, this is an ideal getaway for someone who wants to experience a serene stay along with connectivity to the airport and the ancient holy city of Varanasi. The property is located between the Airport and the main city situated at the bank of Ganga River.
$34 за ніч
Окрема кімната · Uttar Pradesh
Deluxe Room Garden View
Namastay Varanasi is a farm stay for peace lovers. The property is located in a village merely at a distance of 7 km from BHU & 4kms from highway. The property has a swimming pool, organic gardens, fruit orchards, lawns and farm land. The rooms are ultra modern with all modern facilities including hi speed wi fi. We do not have a TV in the building but for activities we have lots of books in our library, games, painting canvas etc. The surrounding is very peaceful and we are pet friendly.
31 жовт. – 7 лист.
$51 за ніч


In the rapidly changing field of vehicle technology, Lesswire CarPlay Wireless Adapter is groundbreaking as it alters our concept of road connectivity.
Breaking Free: What Lesswire CarPlay Wireless Adapter Symbolizes
For any driver who wishes to break free from the bonds that typically keep them connected to their cars, Lesswire CarPlay Wireless Adapter provides a guiding light. The novel adapter connects wirelessly with the infotainment system of vehicles, thus liberating drivers from being restricted by hitherto messy wires and facilitating cleaner driving spaces.
Effortless Integration: Easing the Setup Process
The simplicity of setting up and integrating the Lesswire CarPlay Wireless Adapter makes it stand out. It comes with compatibility for various car models, making pairing with an existing infotainment system trouble free. The lesswire adapter is there for you whether you are an expert tech individual or a beginner making this product usable by anyone which aims at enhancing everyone’s driving experience.
Elevating Safety: Driving without Wires
The Lesswire CarPlay Wireless Adapter greatly enhances driving safety by eliminating the need for wired connections. Drivers can concentrate on what is happening in front while enjoying all features in an infotainment system that is completely connected and has no cables to distract them. In this sense, both convenience and safety are prioritized at once as Lesswire keeps pace with the changing demands of today's drivers.
Universal Compatibility: Works with Various Cars Models
Lesswire CarPlay Wireless Adapter is highly versatile in that it supports a wide range of cars. For example, sedans, SUV’s or compact cars can use the wireless accessibility guaranteed through this adapter available in its entire range across all the categories of vehicles driven by variety of people whose needs differ from each other.
Future-Ready: Adapting in Line with Technological Evolution
Lesswire CarPlay Wireless Adapter is indeed a reflection of future trends in-car connectivity since it was designed purposely to adapt together with advancing technology. It is updated regularly so that it can keep pace with new developments in wireless connectivity.
The Lesswire CarPlay Wireless Adapter is not simply an accessory, but a revolutionary element within the automotive connectivity technology. Go wireless, make integration simple and attain higher driving standards.


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Ethereum has been pushing higher throughout the past day alongside Bitcoin and most other major altcoins.
This climb has come about after an extended period of sideways trading within the lower-$200 region. It does appear that buyers are now attempting to lay the groundwork for it to see even further upside.
One analyst even believes that there is a simple path forward for ETH to set fresh yearly highs of over $290.
In order for this possibility to come to fruition, it is imperative that buyers garner enough buying pressure to firmly surmount the upper boundary of the massive trading range that Ethereum has formed throughout the past several weeks.
Ethereum Garners Upwards Momentum as Buyers Target Range Highs
At the time of writing, Ethereum is trading up just over 2% at its current price of $212. This marks a notable upswing from daily lows of $205 that were set earlier today when sellers attempted to spark a selloff.
Much of ETH’s present strength is rooted in that of Bitcoin.
The benchmark cryptocurrency is currently pushing up towards $9,500 – with this marking a notable breakout rally that has come about after its recent defense of its key support at $8,800.
It is important to note that the upper-$9,000 region is laced with resistance. As such, the cryptocurrency could be positioned to decline significantly if it is unable to navigate through the heavy selling pressure seen there.
Regardless of BTC’s near-term trend, analysts are growing increasingly bullish on Ethereum.
Popular trader Nik Patel noted in a blog post that the first key level that ETH must surmount sits around its multi-week range high at $217. A break of this level could lead it to $228.
“I am waiting for a clean break either side of the range to give me a clue as to where this wants to move for the subsequent weeks; break above $217 and I think we test $228,” he noted, further adding that a close above $228 would lead it straight to $254.
ETH Could Soon See a Movement to Yearly Highs
Patel isn’t the only one who believes a movement towards $250 is in the cards, as another trader recently offered a chart showing a similar target.
As seen above, this target also coincides closely with a descending trendline that has been formed over the past few months.
Patel doesn’t believe that the uptrend will necessarily stall here, however, as he also explains that a firm move above $250 would open the gates for Ethereum to rally to fresh yearly highs.
“Close the weekly above [$228] and I’ll be taking longs all the way up to $254; above that and I think we make a higher-high above $290,” he concisely stated.
Featured image from Shutterstock.


How global warming could cause animal-to-human pandemics
A new study suggests species migration could lead to novel viruses in the future.
According to a new study, climate change will put more pressure on species to migrate and provide thousands of new opportunities for viruses to move from one species to another in the coming decades.
These occurrences may raise the likelihood of a human pandemic. Ebola, HIV, avian flu, SARS, and many scientists believe COVID-19 all began with viral transmission from wildlife and cattle to people.
Read more: World must brace for 30% more wildfires by 2050: UN
The study, published in the Nature journal, indicates how climate change and ecological changes in habitats would drive viruses' host animals to new locations where they will interact with other species for the first time.
These inter-species interactions will increase viral reservoirs, endangering endangered species and increasing the likelihood of viruses spreading to humans.
Thomas Gillespie, a disease ecologist at Emory University states that the study stresses " there are lots of cross-species transmission events that are happening now, and many more that can happen as environments are changing."
If warming is maintained to less than 2°C above preindustrial levels, the researchers predict that hundreds of thousands of first contacts between species will occur over the next five decades, resulting in more than 4,500 viral transmissions from one species to another.
According to the findings, the majority would occur in high-elevation environments with diverse biodiversity in tropical Africa and Asia.
Similar processes will be witnessed in the decreasing expanses of species-rich tropical primary forests. Many of these locations are also where cities and crops are grown.
"Climate change is creating innumerable hotspots of future zoonotic risk or presents a zoonotic risk right now in our backyard," Colin Carlson, a disease ecologist at Georgetown University and co-author of the study, said in a press conference, using the term "zoonosis," which refers to viruses that jump between species.
Even if carbon emissions are reduced, the new study's models reveal that the increase in viral sharing occurrences is not entirely prevented. And the study reveals that some of them are already being driven by climate change.
According to Gillespie, "The bottom line is the majority of the viral sharing events are going to happen over the next 20 years and going to happen regardless of how well we mitigate climate change within that window."
Gregory Albery, who also studies disease ecology at Georgetown says the work "provides us more incontrovertible evidence that the coming decades will not only be hotter, but sicker."


A Tensor-Free Method for the Structural and Dynamical Refinement of Proteins using Residual Dipolar Couplings.Camilloni, C., Vendruscolo, M.
(2015) J Phys Chem B 119: 653-661
- PubMed: 24824082
- DOI: 10.1021/jp5021824
- Primary Citation of Related Structures:
- PubMed Abstract:
- Validation of Protein Structure from Anisotropic Carbonyl Chemical Shifts in a Dilute Liquid Crystalline Phase.
Cornilescu, G., Marquardt, J.L., Ottiger, M., Bax, A.
(1998) J Am Chem Soc 120: 6836
Residual dipolar couplings (RDCs) are parameters measured in nuclear magnetic resonance spectroscopy that can provide exquisitely detailed information about the structure and dynamics of biological macromolecules. We describe here a method of using R ...
Residual dipolar couplings (RDCs) are parameters measured in nuclear magnetic resonance spectroscopy that can provide exquisitely detailed information about the structure and dynamics of biological macromolecules. We describe here a method of using RDCs for the structural and dynamical refinement of proteins that is based on the observation that the RDC between two atomic nuclei depends directly on the angle ϑ between the internuclear vector and the external magnetic field. For every pair of nuclei for which an RDC is available experimentally, we introduce a structural restraint to minimize the deviation from the value of the angle ϑ derived from the measured RDC and that calculated in the refinement protocol. As each restraint involves only the calculation of the angle ϑ of the corresponding internuclear vector, the method does not require the definition of an overall alignment tensor to describe the preferred orientation of the protein with respect to the alignment medium. Application to the case of ubiquitin demonstrates that this method enables an accurate refinement of the structure and dynamics of this protein to be obtained.
Department of Chemistry, University of Cambridge , Cambridge CB2 1EW, U.K.


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Sickle cell anemia and Thalassemia are lifelong genetic disorders characterized by Red Blood Cells that assume an abnormal sickle shape, abnormal hemoglobin structure. Sickling and structural change of hemoglobin decreases the flexibility of the cell and results in risk of various complications. This alters the cells morphology and this result can be used for classification. The proposed system takes a magnified image of the blood smear and applies various image processing techniques to detect the different disorders of red blood cell. White blood cells, platelets will automatically be removed from the image; this reduces the region of interest.
Keywords : Image Processing, Edge detection, Shape Detection, Sickle Cell, Thalassemia, K-means, Ellipse Detector.


A friend of mine sent me a link to The Chosen a year or so ago. We watched the first and only season and instantly fell in love with it. It’s a very well done series about the Savior’s ministry and although it takes quite a bit of artistic license in its telling of the story, it’s done so very well and is incredibly uplifting.
I have since shared the link with many friends and have contributed to the producer’s efforts to raise money for Season 2. For Season 1, they raised over $10M. More than any other crowdfunded film project in GoFundMe history. They hope to do 8 or more seasons and will need about $10M per season. I highly recommend The Chosen to anyone who has yet to see it. You can click on the link below to watch the first episode and season for free:
Here’s a quick sampling:
I think the reason The Chosen has been such a huge success is because of how real the characters are made to feel. Jesus, for example, says things like, “Hey good to see you boys!” He belly laughs and smiles ear to ear on more than one occasion. He feels real. Authentic. Relatable. Approachable. Human, although God-like. He speaks and acts like you might imagine a real person in real life would, even if the Son of God.
Of course, the actors and director know full well, they are not perfectly depicting the characters they are trying to portray, but without question, they have brought a tremendous amount of real-life personality to these seminal figures. Capturing and portraying authenticity is no easy task in the world of cinema, especially when depicting the Savior and other old world prophets.
Authenticity in real life is an even more refreshing thing to witness. Most people want real. Especially from the preachers of religion. Those who are stiff and scripted and speak fancifully in a way that is not relatable may indeed be loved and may even be revered, but they are not going to be very effective, in my opinion. They can control meetings and membership and tempo and curriculum and hierarchy, but they will not truly convert souls unto Christ. Not when approaching the effort in a superficial, scripted way. And certainly not when being dishonest or unwilling to address people’s real-life concerns and questions.
A friend of mine recently highlighted remarks made in a Face to Face by Elder Rasband. His post covered the comments Elder Rasband made about how they, the 15 prophets, seers, and revelators, receive revelation—through a process of collaboration, drafts, and edits. Bare Record’s post led me to watch the full event, which you can find below.
The news of how the Brethren receive revelation may be disappointing for those who still believe they “see the Lord” (as did Joseph) or hear His Voice. Their process is the same as for anyone trying to be inspired but clearly is NOT prophetic by the standards of Scripture. Yet, somehow their way is viewed as better than our own.
Elder Rasband teases in this particular Face to Face that he was grateful that a “couple of his words” made it into the final cut and that when they had all written their drafts, they gave them to the Prophet for him to put it all together. In other words, although all 15 men are prophets, seers, and revelators–the newer the prophet you are, the less important and less respected and less inspired you are by your peers (and possibly by the membership too). None of it feels “genuine” or authentic. It feels mechanical and scripted. I.e. NOT prophetic.
As I tuned in I was very surprised to see that the Church filmed this episode of Face to Face on their Goshen, Utah film set. Apparently, they had planned on filming the event from the Sacred Grove in upstate New York but changed their plans officially on August 10, 2020.
It would be at about that same time that the filmmakers and supporters of The Chosen were fasting and praying to find a location where they could film their second season. And It was at about this same time that the Church agreed to let them “use” the Goshen location. (I don’t know if it’s being donated or rented out). The director of The Chosen made the announcement of the new film location on August 19th, only 9 days after the Church announced its change of venue. Surely, negotiations to use the Goshen location would have been ongoing for weeks if not months before officially securing it. The Chosen view the location as a miracle from God and an answer to their prayers.
But, one may ask, why did the Church change venues at the last minute for its Face to Face to the new set of Season 2 for The Chosen? Why Goshen? I don’t know the answer but, I find it strange that the Church would just happen to move their big event to a location it had just rented out to the amazingly popular Christian series as if wanting to associate itself with the success of the production. The timing is suspect at best and the location for this type of event I believe is unprecedented. It feels very much like the Church is trying to benefit from the popularity of The Chosen, which for me, is a very superficial and shallow thing to do. The least they can do is FUND several seasons! At least then, they can say they helped the cause, instead of surreptitiously trying to promote themselves.
In watching the Face to Face with Elder Rasband, I was struck at how unauthentic it all was. The entire event is supposed to be homey. I think it’s meant to be a modern-day “fireside chat with one of the 15 prophets.” In-person and up close are meant to carry the day. Not scripted and stiff, and evasive.
In this event, every question from the LDS youth of the world is handpicked and responses are all planned in advance. The setting feels extremely stiff with all of the handpicked audience sitting 6 feet apart and all donning the politically correct masks, even though outside on a desert film set. The message seems to be all about exactness. Exactly 6 feet apart. Exactly obedient. Exactly scripted. Exactly in line with the Men who lead the Church.
The first two questions to Elder Rasband are truth claims questions. One from a young Latter-day Saint man named Harry who is considering leaving the Church. Elder and Sister Rasband’s response is effectively, “Don’t you dare leave! If you do, your life will be ruined!” They then turn the audience to a film about a young man who was going to commit suicide, because he was not a member of the Church. The story was nice enough, but I had to wonder how Harry must have felt. “If you leave Harry, your life will be meaningless and you too will likely want to commit suicide. It’s the Church or it’s eternal Misery!”
What people like Harry and Harriet (the other truth claims questioner) want, is someone to be real with them. In my opinion, they just want authenticity. They crave real answers to real questions. And what they get is the inauthenticity of a geriatric version of High School Musical. Lots of theatrics and nice music. So much “niceness” and so many smiles, but no real answers.
Here a just a few of the comments online from those who sympathize with Harry and Harriet:
Why do we need to shelf these items? If these are truly men of god, why can’t they answer the questions? Instead they dodge it and say “just shelf it” well I’ve shelfed it for 36 years and my shelf is broken because of the weight.
Same here. They can’t answer the questions, because if they do, they admit to being wrong.
The thing is……many of us HAVE opened up and sought truth from the Holy Ghost when the leaders of the church were unwilling or unable to provide it. The truths we have found from the Lord speaking through his spirit are that the church and its leaders are not what they claim to be. While this is inconvenient for the church and its truth claims, what we have learned is, nonetheless, true. There is no need to shelve these items. The Lord will answer your prayer. The truth, the knowledge, the answers may not be what you WANT them to be, they may not affirm what you have believed your entire life, but they are real. I am so glad that the Lord has made me aware of this and that I have found a deeper, richer spiritual experience in a different church.
The music felt a little American Idol for me.
The thing that got me was hearing elder and sister Rasband respond to a question from a member wondering if they should resign from the church with a video about an individual struggling with mental illness and suicide…. How are those related exactly?
It is so sad how they are given the opportunity to say the right thing and they totally blow. Their responses to concerns were completely irrelevant. Someone struggling with Truth Claims of the church needs answers!
I was disappointed that when a person mentions struggling in the faith over doctrine or history that the issues are never explored. Why is this so? It would seem only natural to want to know what people struggle with in order to shepherd them in the faith. I personally have struggled with discrepancies between the Book of Abraham text and what Egyptologists report from scholarly translation of the fragments in the possession of the church. Nobody in the church seems willing to talk about this or my concerns with the various versions of the Joseph Smith story..
You’re not alone. Anyone who is observant and objective will recognize that the church is dodging the issues. At the very least…the very LEAST…Rasband could have directed the questioner to the Gospel Topics Essays that address these issues on the church’s own website!! But he couldn’t even bring himself to do that. And why?? Because he is aware that many people have left the church precisely BECAUSE of what they learn from the Gospel Topics Essays. Talk about your dereliction of duty!
I really do not like that they screened and prepared the questions and “answers” in this meeting. It feels very staged. I would have liked to have seen honest real answers off the cuff. The emotional manipulation here is intense for those still inside the church bubble. Take one foot out of it and you can see what this really is. Sadly, many never will for fear of losing family and friends, and that’s a legitimate fear. Especially if you live in Utah.
Sadly, many who struggle, see these Face to Faces with “the Prophets” as shallow and unhelpful. The above questions and comments are sincere and worthy of consideration. Why can’t these men be more relatable? Approachable? Off the cuff? Real? I’d invite you to watch the Face to Face for yourself if you haven’t already.
There’s a story that Sister Rasband shares where she was hit by a car as a little girl because she did not listen to the Spirit warning her. Elder Rasband thanked her (no fewer than 1,000 thank you’s in this F2F) and told her while getting choked up that “Their family’s faith has been built on her telling this story so many times over the years.” I’m sorry but the exchanges between Elder and Sister Rasband seem very unnatural. You can watch and decide for yourself.
I also do not like that Elder Rasband stops midway through and asks the audience to #hashtag the event and to “follow the prophet” on social media. Reminds me of the scene in the Truman Show where out of the blue, Truman’s wife takes a moment to thank the Show’s sponsors:
So much advertising. So many hushed tones. So much superficial reverence. So many thank you’s. There’s even a “scene” where Elder Rasband stops the tape and reinforces that HE and HIS WIFE KNOW the SAVIOR! This is their gift! According to him, it’s other people’s gift to believe on their testimony. Sure seemed like Elder Rasband was checking off a box to reinforce to the audience his assignment to be a “special witness.”
Another interesting moment is when Sister Rasband refers to “Anti-Church literature.” I always knew this as “Anti-Mormon” literature, but I assume that Sister Rasband is trying very hard to not use the word “Mormon” in any way, in accordance with the current prophet’s teachings. A little awkward. I wonder if the Church will buy websites such as: “memberofthechurchofjesuschirstoflatterdaysaintsandgay.com so as to be exactly obedient to President Nelson’s teachings.
All in all, the lack of authenticity carried the day. Now, having said that, there are incredibly talented people who sing and there are people there who are amazingly sincere, who surely God loves and watches over. But, Mormonism has sadly become something that appropriately feels very staged and scripted. It belongs on a movie set. They would do well to learn that real, raw, and authentic are always better than staged, scripted, and phony. They need to learn from The Chosen, rather than trying to hijack their spotlight. Again, the Church would do well to give The Chosen millions of dollars. It would be a far better investment than in the City Creek Mall or in the Book of Mormon Musical (aka Hale Theater), which is a very “anti-Church” production.


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Paradeisos Dress Dora
The Paradeisos Dress Dora is an elegant yet relaxed garment. The V-neck top is adorned with pleated shoulder accents for an alluring look, and the dress extends to calf length for sophisticated style. This look can be easily styled with our vintage jewelry selections.
Product Details: Wide fit, short sleeves, calf-length, V-neckline
Size & Fit: The model (180cm) is wearing One Size - this style fits from EU 34 to 44
Made in Germany
This style can be adjusted to your specifications. If you have any wishes regarding alterations or sizing, contact us directly via WhatsApp or email. We are here to help!


Nedbank Cup Coming To DStv Access Customers
SuperSport viewers on DStv can look forward to riveting football action with the upcoming Nedbank Cup semi-finals starting in May.
Orlando Pirates against Kaizer Chiefs on Saturday, 6 May. The football action does not stop there, the very next day features giant killers Stellenbosch against Sekhukhune United.
As a bonus for DStv viewers, both the Nedbank Cup semi-finals and the final will also be available to DStv Access customers.
This means the Chiefs vs Pirates playoff will be on 6 May at 15:00 and the Stellenbosch vs Sekhukhune United last-four match on 7 May at 18:00.
The title decider on 27 May will be available to more viewers than ever before.
Get Pindula News on our WhatsApp Channel
Subscribe here: https://whatsapp.com/channel/0029Va84dngJP21B2nWeyM3v
The action will be broadcast on SuperSports Variety 4, and will additionally be available for streaming via the DStv app.
More: Pindula News


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PUMPKIN HOUSES watercolor illustration available as an art print.
You can choose in the drop-down menu between different-sized fine art prints.
Manually printed with love on Hahnemühle Fine Art textured paper from my studio in Germany. ♡
The special paper gives the drawings the appearance of being hand-drawn.
Our A3 and A2 prints are shipped with DHL and include a tracking number. Drawings are packaged in premium sturdy roll tubes to ensure their safety during shipping.
RETURN & REFUND POLICY
I created the "Pumpkin houses" illustration in autumn, inspired by the cozy houses of Berlin.
People decorate their homes so beautifully in fall, with loads of pumpkins, leaves, and cute fairy lights. Of course, all the mice, bunnies, and birds begin to make their tiny houses in the pumpkins until winter comes!


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Drug interactions between Latisse and Lumigan
|Latisse (bimatoprost topical)|
|Lumigan (bimatoprost ophthalmic)|
Interactions between your drugs
bimatoprost ↔ bimatoprost
Applies to:Lumigan (bimatoprost ophthalmic) and Latisse (bimatoprost topical)
Treatment with bimatoprost topical ophthalmic may interfere with the pressure-lowering effect of bimatoprost ophthalmic in the eye. Talk to your doctor if you have any questions or concerns. You may need more frequent eye examinations to safely use these medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
No results found in our database - however, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.
Therapeutic duplication warnings
No therapeutic duplications were found for your selected drugs.
Drug Interaction Classification
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.


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Coffee for Peace
Coffee for Peace started as an income-generating project of Peacebuilders Community, Inc., a mission agency focusing on advocating for “Peace”.
The company did research on coffee availability in the Philippines, especially the Arabica variety, because it grows best on highlands. They found out that the Philippines used to be the Number 2 exporting country of coffee in the 1600s. Coffee Arabica is available in Mindanao.
The company experimented on the possibility of marketing their coffee locally and globally. They want it of global standard because if they want to compete locally, they must first sell it outside our country.


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The Practice of Medicinal Chemistry, Third Edition
Huge Savings Item! Save 16% on the The Practice of Medicinal Chemistry, Third Edition by Academic Press at Diseasome. Hurry! Limited time offer. Offer valid only while supplies last. The Practice of Medicinal Chemistry fills a gap in the list of available medicinal chemistry literature. It is a single-volume source on the
The Practice of Medicinal Chemistry fills a gap in the list of available medicinal chemistry literature. It is a single-volume source on the practical aspects of medicinal chemistry. Considered ""the Bible"" by medicinal chemists, the book emphasizes the methods that chemists use to conduct their research and design new drug entities. It serves as a practical handbook about the drug discovery process, from conception of the molecules to drug production.
The first part of the book covers the background of the subject matter, which includes the definition and history of medicinal chemistry, the measurement of biological activities, and the main phases of drug activity. The second part of the book presents the road to discovering a new lead compound and creating a working hypothesis. The main parts of the book discuss the optimization of the lead compound in terms of potency, selectivity, and safety.
The Practice of Medicinal Chemistry can be considered a ""first-read"" or ""bedside book"" for readers who are embarking on a career in medicinal chemistry.
NEW TO THIS EDITION:
* Focus on chemoinformatics and drug discovery
* Enhanced pedagogical features
* New chapters including:
- Drug absorption and transport
- Multi-target drugs
* Updates on hot new areas:
NEW! Drug discovery and the latest techniques
NEW! How potential drugs can move through the drug discovery/ development phases more quickly
|Item Weight:||4.85 pounds|
|Item Size:||1.6 x 11 x 11 inches|
|Package Weight:||4.8 pounds|
|Package Size:||8.9 x 1.7 x 1.7 inches|
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domain: chemistry


text:
Biochemical compounds, including amino acids, nucleotides, vitamins, and other organic and inorganic chemicals, can be found in biological systems. Biochemical reagents are salts, detergents, and other molecules used to in assays and investigations of biological reactions.
Our complete line of biological buffers includes powders, salts, pre-mixed buffer solutions, and other buffer formulations that enhance life science workflows.
For Research Use Only. Not for use in diagnostic procedures.

domain: biology


text:
‘Alien’ mummy DNA probe may have crossed ethical lines:
The severely elongated head of a preserved skeleton discovered in Peru’s Atacama Desert in 2003 is so unusual that it initially prompted people to suggest that the diminutive body was that of an extraterrestrial.
Since then, DNA testing affirmed that the remains — which measure about 6 inches (15 centimeters) long — belonged to a human fetus that specialists named Ata.
But the researcher who conducted that investigation and published their findings in March has recently come under fire for their methods.
Another group of researchers presented an evaluation of the earlier examination, publishing an analysis in the International Journal of Paleopathology.
They criticized the prior research, suggesting that its conclusions about the skeleton’s so-called abnormalities — such as missing ribs — reflected an incomplete understanding of normal fetal development. That mistaken interpretation of the remains led the researchers to proceed with DNA extraction that damaged part of the skeleton.
Their examination, which did not include any Chilean researchers, may have sidestepped protocols that typically monitor the ethics of research conducted with human remains, as their publication omitted “a sufficient ethics statement or archaeological permit,” Kristina Killgrove, co-author of the new investigation and an assistant professor of anthropology at the University of West Florida, wrote in an article for Forbes.
In the new paper, the authors pointed out that the mummy’s unusual-looking skull and body were not necessarily the result of “anomalies,” as the previous research suggested.
Rather, the skull could have been elongated by vaginal delivery of the preterm fetus, while heat and pressure underground after the body was buried could have further compressed the cranium, the researchers reported.
The authors of the new investigation also questioned the earlier research’s suggestion that “novel mutations” could explain the mummy’s size.
The authors noted that skeletal development at the fetus’ suspected age, 15 weeks, would not have been affected by the genetic variants that the researchers described in the previous study.
Since the remains are thought to be just a few decades old, studying them raises ethical concerns that the March study did not adequately address, the scientists in the new study said.
Furthermore, as DNA extraction can destroy some of the body tissues, also restrictions typically apply for such an examination.
And it is unclear from the prior study that DNA sampling was required to begin with, the scientists said.
“Unfortunately, there was no logical rationale to undertake genomic analyses of Ata, because the skeleton is normal,” the authors wrote in the new study, adding that the whole-genome testing previously performed “was unnecessary and unethical.”
“We caution DNA analysts about getting involved in cases that lack clear context and legality, or where the remains have resided in private collections,” the study authors concluded.