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Vaccine stimulates multi-pronged immune attack, inhibits tumor-induced immune suppression
Scientists are using their increasing knowledge of the complex interaction between cancer and the immune system to engineer increasingly potent anti-cancer vaccines. Now researchers at the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have developed a synergistic nanovaccine packing DNA and RNA sequences that modulate the immune response, along with anti-tumor antigens, into one small nanoparticle. The nanovaccine produced an immune response that specifically killed tumor tissue, while simultaneously inhibiting tumor-induced immune suppression. Together this blocked lung tumor growth in a mouse model of metastatic colon cancer.
The molecular dance between cancer and the immune system is a complex one and scientists continue to identify the specific molecular pathways that rev up or tamp down the immune system. Biomedical engineers are using this knowledge to create nanoparticles that can carry different molecular agents that target these pathways. The goal is to simultaneously stimulate the immune system to specifically attack the tumor while also inhibiting the suppression of the immune system, which often occurs in cancer patients. The aim is to press on the gas pedal of the immune system while also releasing the emergency brake.
A key hurdle is to design a system to reproducibly and efficiently create a nanoparticle loaded with multiple agents that synergize to mount an enhanced immune attack on the tumor. Engineers at the NIBIB report the development and testing of such a nanovaccine in the November issue of Nature Communications.1
Making all the parts fit
Guizhi Zhu, Ph.D., a post-doctoral fellow in the NIBIB Laboratory of Molecular Imaging and Nanomedicine (LOMIN) and lead author on the study, explains the challenge. “We are very excited about putting multiple cooperating molecules that have anti-cancer activity into one nanovaccine to increase effectiveness. However, the bioengineering challenge is fitting everything in to a small particle and designing a way to maintain its structural integrity and biological activity.”
Zhu and his colleagues have created what they call a “self-assembling, intertwining DNA-RNA nanocapsule loaded with tumor neoantigens.” They describe it as a synergistic vaccine because the components work together to stimulate and enhance an immune attack against a tumor.
In addition to engineering a system where the DNA, RNA and tumor neoantigens self-assemble into a stable nanoparticle, an important final step in the process is shrinking the particle. Zhu explains: “Shrinking the particle is a critical step for activating an immune response. This is because a very small nanoparticlecan more readily move through the lymphatic vessels to reach the parts of the immune system such as lymph nodes. A process that is essential for immune activation.”
The method for shrinking also had to be engineered. This was achieved by coating the particle with a positively charged polypeptide that interacts with the negatively charged DNA and RNA components to condense it to one-tenth of its original size.
Testing the vaccine
The nanovaccine was injected under the skin of the mice 10, 16, and 22 days after the colon cancer cells were injected. To compare to the nanovaccine, two control groups of mice were analyzed; one group was injected with just the DNA and the neoantigen in solution but not formed into a nanovaccine particle, and the second control group was injected with an inert buffer solution.
At 40 days into the experiment, lung tumors from the nanovaccine-treated and the control groups were assessed by PET-CT imaging, and then removed and weighed. In mice treated with the nanovaccine, tumors were consistently one tenth the size of the tumors that were found in mice in both control groups.
Further testing revealed that mice receiving the nanovaccine had a significant increase in circulating cytotoxic T lymphocytes (CTLs) that specifically targeted the neoantigen on the colon cancer cells. CTLs are cells that attack and kill virus-infected cells and those damaged in other ways, such as cancerous cells.
An important aspect of the nanovaccine approach is that it mounts an anti-tumor immune response that circulates through the system, and therefore is particularly valuable for finding and inhibiting metastatic tumors growing throughout the body.
The researchers view their nanovaccine as an important part of eventual therapies combining immunotherapy with other cancer killing approaches.
The Latest on: Nanovaccine
- New nanovaccine for deadly skin canceron August 6, 2019 at 5:36 am
Tel Aviv scientists have published their version of a vaccine against the deadly skin cancer malignant melanoma, which arises from the pigment producing cells of the skin. This is the most feared form ...
- Melanoma Checkpoint Therapy More Potent in Combination with Nanovaccineon August 6, 2019 at 3:10 am
Performing in vitro and animal studies, the TAU scientists combined several forms of immunotherapy, reaching a most effective crescendo when they added a nanovaccine—a particle made of biodegradable ...
- Nanovaccine Confers Dual Protection Against Influenza A Virus And Porcine Circovirus Type 2on June 1, 2019 at 5:00 pm
Methods: In the present study, M2e of different copy numbers were inserted into the capsid (Cap) protein of PCV2 and expressed in Escherichia coli to form self-assembled chimeric virus-like particles ...
- Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer typeson April 23, 2019 at 5:00 pm
The nanovaccine consists of tumor antigens - tumor proteins that can be recognized by the immune system - inside a synthetic polymer nanoparticle. Nanoparticle vaccines deliver minuscule particulates ...
- Nanovaccine Boosts Metabolic Syndrome Immunityon March 30, 2019 at 12:58 pm
In mice with metabolic disorders, nanovaccine developed by Cornell researchers was found to boost immunity. Metabolic disorders are linked to gut bacteria - a population that shows resistance to ...
- Metabolic Disorder Immunity Boosted by Nanovaccineon March 29, 2019 at 4:54 am
[Jason Koski, Cornell University] Scientists at Cornell have developed a novel class of biomaterials for an infectious disease nanovaccine that increased immunity in mice with metabolic disorders ...
- Nanovaccine boosts immunity in mice with gut microbiome-mediated metabolic syndromeon March 29, 2019 at 1:11 am
A new class of biomaterial developed by Cornell researchers for an infectious disease nanovaccine effectively boosted immunity in mice with metabolic disorders linked to gut bacteria - a population ...
- Nanovaccine boosts immunity in sufferers of metabolic syndromeon March 28, 2019 at 1:38 pm
A new class of biomaterial developed by researchers for an infectious disease nanovaccine effectively boosted immunity in mice with metabolic disorders linked to gut bacteria -- a population that ...
- Researchers developing, testing nanovaccine to protect against the flu viruson December 12, 2017 at 6:04 am
Researchers from Iowa State University, the University of Iowa and the University of Wisconsin-Madison – all of them affiliated with Iowa State’s Nanovaccine Institute – are working together to ...
via Google News and Bing News

domain: chemistry


Following the decision to leave the EU, the UK needs to reconfigure its trade policy, successfully navigating a path through a new international trade landscape. The UK Trade Policy Observatory aims to ensure that new trade policies are constructed in a manner that benefits all.
For over four decades, the EU has handled most elements of international trade policy on Britain’s behalf. Brexit changes all that and there is now an urgent need to debate and define the UK’s place in the international trading system and then to negotiate it with our partners. This requires expert analysis, commentary and inputs from people experienced in trade policy formation and practice.
The UK Trade Policy observatory (UKTPO), a partnership between the University of Sussex and Chatham House, is an independent expert group that:
1) Initiates, comments on and analyses trade policy proposals for the UK;
2) Trains British policymakers, negotiators and other interested parties through tailored training packages.
Created in June 2016, the UKTPO is committed to engaging with a wide variety of stakeholders to ensure that the UK’s international trading environment is reconstructed in a manner that benefits all in Britain and is fair to Britain, the EU and the world.Latest Briefing Paper - A Post-Brexit Generalized System of Preferences for the UK
Our videos help to explain the effects of Brexit.
‘Brexit: Where does it hurt?’ portrays the potential shock that a ‘no deal’ Brexit may have on jobs across 632 parliamentary constituencies in Britain. Many studies, including the Government’s own analysis, suggest that Brexit will be costly for the UK because it will increase the costs of trading with the EU. Based on an estimate that suggests a ‘no deal’ Brexit will cause national GDP to fall by about 2.5%, we find that job losses tend to be concentrated in large areas of employment, such as cities and large towns. Yet, once we allow for commuting, the economic cost of Brexit is much more widely spread. We must stress that we are not asserting that the number of jobs lost will be equal to our estimates. People may avoid job losses resulting from lost international trade by accepting lower wages or shorter hours or by moving away, all of which will look different in terms of jobs, but these responses are merely different ways of accommodating to the same negative shock. What is clear, is that the Brexit shock would eliminate a particular number of jobs. For a detailed explanation of the research for this video, please see explanatory note in ‘The vulnerability of different parliamentary constituencies to Brexit economic shocks’
‘Grandfathering the EU’s Free Trade Agreements’ explains why rolling over these agreements is likely to be highly complicated, and will necessarily impact on trade. When the UK leaves the EU, it must also leave the EU’s free trade agreements with over 60 countries that it is currently a member of via the EU. The UK government intends to roll over these agreements so that they continue to apply, known as grandfathering. However, because of Rules of Origin and other clauses in some of these agreements, this will not be a simple cut and paste ‘UK’ job. This video explains why rolling over these agreements is likely to be highly complicated, time-consuming and will necessarily impact on trade.
‘The ins and outs of the Single Market’ explains what the Single Market is, how it works and the ways it effects trade, and thereby the economy. Ultimately, the video explains that there is a trade-off between making your laws independently and cooperating sufficiently to be a part of a bigger market and achieve higher incomes.
‘The Customs Union: The Fiction of ‘Frictionless’ Trade’ shows what leaving the EU Customs Union entails and that you need much more cooperation than just a customs union in order to achieve the same level of trade costs as we have now.
‘With or without EU’ shows that in terms of trade policy choosing trade priorities on the basis of aggregate UK data does not take into account the fact that the nations within the UK are exposed to trade with the EU in different ways.
Charlotte Humma November 25th, 2016
Share this article: Julia Magntorn Garrett is a Research Officer in Economics at the University of Sussex and a fellow of the UK Trade Policy Observatory. On Thursday last week (May 30) President Donald Trump threatened to levy tariffs on all US imports from Mexico. The UK should take note, as this has implications not only for Mexico, but for the UK as well.
Charlotte Humma June 7th, 2019
Posted In: UK - Non EU
Share this article: 15 May 2019 Chloe Anthony, Ffion Thomas and Emily Lydgate In this blog, we take a closer look at the legislation that is being used to bring existing EU pesticide regulations into UK law in preparation for leaving the EU. We find that departures from EU pesticides legislation are significant. The new legislation consolidates powers to UK ministers to amend, revoke and make pesticide legislation and weakens both enforcement arrangements and the requirement to obtain scientific advice.
Charlotte Humma May 15th, 2019
Posted In: Uncategorised
Share this article: 30 April 2019 Dr Minako Morita-Jaeger is an international trade policy consultant and an Associate Fellow of the UK Trade Policy Observatory. The UK managed to avoid crashing out of the EU on 12th April for the second time. But this delay extends uncertainty since the possibility of a No-deal Brexit on 31st October remains. The UK’s trade partners have been looking at Brexit uncertainty with great dismay. Japan is not an exception. Here, I highlight how this uncertainty is affecting Japanese businesses in Europe and analyse possible future UK-Japan trade relations based on the three scenarios currently in the UK political debate. This provides an update to the UKTPO blog on UK-Japan relations. UK’s relative market attractiveness declining in Europe On-going Brexit uncertainty has been diminishing confidence in the UK. According to the JETRO’s (Japan External Trade Organization) annual business survey, Japanese businesses’ evaluation of UK’s… Read More
Charlotte Humma April 30th, 2019
Posted In: UK - Non EU


I have two issues 1. I am trying to get esata drives configured for our backups on our main server. We have a startech esata pci-e card for the server. Every time we install the card and hook up a drive the server hangs. Does anyone know how we can get this configured. I installed the card on my desktop which is running vista and it doesn't lock up. the drive shows up but I don't have the option to safely eject the drive and hook up another drive. The other problem is we just bought a new hp laptop which has a built in estata port we hooked one of these drives up to it to see if it would work better since it is built into the motherboard. This laptop is running windows 7. Most of the time it doesn't even recognize that a drive is connected. Twice it popped up the new hardware found box but failed to install drivers. I checked on the Iomega web site for drivers for these drive cages and they don't have any. Any one have any ideas or can explain e-sata drives better for me and can they be used like usb or firewire drives
Could be a lot of things... have you tried moving the card around to different slots in the server? Upgrade the drive and controller firmware to the latest? Also it causing problems on the other computer may lend to it being an actual bad drive.. have you tested this? Also if you are using an esata enclosure for multiple drives, check and see if there is a firmware update for the backplane as well
These are brand new drives and they work via the usb port on the external drive cages. Since we can't get the esata part to work we have been using them for backups via usb but our backups are taking over 8 hours and slowly increasing as the amount of data grows. Hench the need for a faster "pipeline" for our backups. I have been to the Iogear website and they don't list any drivers for our model of drive cage. We are using segate hard drives.
Then it might be an issue with the cage itself since the same problem happens across systems but strangely only with the esata port. Have you tried obtaining warranty support for these?
Not the same issue, but I tried using a Promise eSATA RAID card and had nothing but problems with it on a Dell Server. Ended up biting the bullet and purchasing the U320 drives to fit into cages inside.
My regard for non-enterprise type add in cards is not too high...


January 23, 2017
This grand Fifth Avenue co-op belongs to the socialite and political fundraiser Georgette Mosbacher, who has hosted everyone from King Juan Carlos I of Spain to Tom Hanks to Presidents George H. W. Bush, Bill Clinton and Donald Trump at her apartment. It occupies the entire fifth floor of 1020 Fifth Avenue, a prestigious limestone cooperative, and it's now asking $29.5 million. Mosbacher, who has lived here since 1992, told the New York Times, "It’s come to a point where I want to make a change in my life, and it won’t happen unless I shake it up." So now the palatial pad could be yours.
Take the grand tour


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Marriage Therapy – Is it Right For You?
Marriage counseling is a process that involves a pair having an open discussion about their problems and after that checking out feasible remedies. Couples counseling normally attempts to boost marital relationships and address interpersonal conflicts prior to they come to be significant problems. The process of marriage counseling can be agonizing, discouraging, as well as time consuming. It may seem like the marriage goes to an end – but it isn’t. You can work out your distinctions as well as save your marital relationship! If you and your companion have had problem interacting, then marriage counseling is for you. The pair’s relationship therapy can assist you both discover just how to communicate better with one another, in addition to finding out how to determine and also stay clear of usual mistakes. It can additionally assist you and your companion establish an understanding of why the relationship is falling short, as well as what you can do to fix it. A terrific therapist will additionally be there for you during these difficult times, when you require them the most. You ought to always be offered the possibility to discuss your connection, so you know your companions’ sights and sensations on the issues. In some cases, one partner might really feel very alone in the relationship. In these instances, pairs counseling might entail one or both companions mosting likely to a support system. Support system can give lots of advantages for both individuals in the connection. Support groups are commonly hung on a revolving basis, so no matter where you go or what type of support you need. With the appropriate team, you as well as your partner can discover just how to sustain each other during times of problem and might also find means to enhance the partnership in various other locations. For pairs who have actually currently been wed for an extended period of time, marital relationship counseling can be an attempting experience. A wonderful way to ensure a much better understanding of what is occurring in your marriage is to see with an expert therapist regularly. Throughout face to face sessions, the therapist will certainly get an understanding of your individualities and also just how they affect your relationship. This kind of counseling will certainly assist to recognize the problems that you as well as your partner are dealing with as well as will certainly offer remedies that might not have actually occurred to you or else. Pairs that consistently go to marriage counseling sessions may discover a big enhancement in their connection. If you don’t think you have enough patience to experience the marriage counseling process, there are other options. Specialists as well as psychologists provide these services also. Nevertheless, these therapists have a tendency to operate in private, which might restrict your accessibility to them. An additional drawback is that these sessions can be costly as well as you might not have a therapist available when you need one on a certain day or for a longer time period. Household specialists, on the other hand, operate in combination with mental health and wellness experts and also are offered twenty-four hours a day, seven days a week. When deciding which therapist to opt for, it is very important to make sure both therapists have similar approaches of using marriage counseling and also are able to provide a high level of customized service. While household specialists function best with couples in dilemma, specialists that specialize in individual therapy may prove useful to a couple in crisis. Once a pair starts treatment, they ought to know how their therapist connects with them. In several circumstances, pairs find that having good communication with the specialist is what aided them settle the problems at hand and led them to the treatment sessions in the first place.

domain: psychology


The Colonials improve to 2-0 against the Patriots for the season. George Washington defeated George Mason 73-67 on Jan. 15. George Washington takes on Duquesne on the road on Wednesday. George Mason faces Richmond on the road on Wednesday.
For more AP college basketball coverage: https://apnews.com/Collegebasketball and http://twitter.com/AP_Top25
This was generated by Automated Insights, http://www.automatedinsights.com/ap, using data from STATS LLC, https://www.stats.com


It has been stated that, ‘charity is the act of extending love and kindness to others unconditionally, which is a conscious act but the decision is made by the heart without expecting a reward’ and that, ‘when charity is carried out selflessly, it is a one-way act where a person gives but asks for nothing in return’.
In Jersey, hundreds of charities are operating daily and all committed to the endeavour of improving the lives of others and asking for nothing in return
Their shared aims are all clear for all to see. Many of these organisations mirror well-known national and international charities, whilst others are much more locally focused and unique.
One might reasonably question the need, in such a small and wealthy jurisdiction such as ours for so many different charities, but clearly there is.
Charitable gifting opportunities are advertised daily across the broadcast media in particular during the build-up to Christmas. Often the hardest gifts to choose now, it seems to me, are those selected to support a particular charity or charities as we search our conscience during the season of goodwill.
Of course, as those working in the charity sector will remind you, for them it's a 365-days-a-year commitment, not just a seasonal event.
Having now attempted to plough my way through the extensive Order Paper that is the focus of this week's States Assembly sitting, I did begin to wonder the exact purpose of the proposed ‘Government Plan’ for 2022-2025 and at last reading its 26 amendments.
Pictured: This week, States Members are debating the Government Plan for 2022-2025.
Of course, we need a plan to tackle all the issues of the day, and the need for the Assembly to debate and decide the best course of action is of paramount importance, but(!) I would guess for most islanders, just dealing with today's challenges and those additional ones on the horizon are more than enough to deal with for now, and of far more pressing importance than those being debated in our parliament.
Christmas can be a challenging time for many, the additional financial burden it places on hard pressed family incomes plus of course the emotional stresses for those unable to be with those they love. This can all take a heavy toll on even the most resilient amongst us. Added to this, and so importantly, are those in need of urgent support from the charity sector such as the homeless, the poor and the lonely.
One hopes that by the end of play on Friday, before the parliamentary recess, our elected States Members have all had plenty of opportunity to speak, debate and vote on their plan. What difference the plans agreed will make is hard to judge before its implementation but we can at least be certain, come next June a new assembly will be formed, new plans will be written, debated and voted on, and the never ending merry go round of politics will continue unabated.
Meanwhile across the island, hundreds of charities will be doing what they have always done, meeting the needs of people as best as they can. They will do so as they do everyday with love and kindness. No need for debate or indeed a plan, it's just a one-way act of giving. Because this is home and it’s where the charity begins.
Priorities are simple when you are faced with an urgent need and, thank God, in Jersey there are still those who just get on and do when there is work to be done.
Let’s hope, for those of us who can, we will find an opportunity to just stop for a moment and reflect on all those engaged in the charity sector and make a gift. We know there is a need and just a little is all it sometimes takes to make a difference.


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June 3, 2022
Veteran Outreach Contact
SCORE San Diego Mentors
Stories this photo appears in:
EMPLOYMENT: Incubator Addresses Unique Job Needs of Military Spouses
Even amidst a tight labor market with excessive job openings, there are some demographics that have not recovered from the pandemic. “There is a 30% unemployment rate right now for military spouses,” said Victoria Carlborg of the Oceanside Chamber of Commerce.

domain: news


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Happy Thanksgiving! Enjoy this quick and simple guided drawing. After creating the simple outline, fill the feathers with fun patterns or designs!
I'm demonstrating with pencil, followed by pen or permanent marker. You can use any supplies you have on hand and experiment to find what works for your project.
Comment or social share your completed projects, I'd love to connect!
Join me for more CREATIVITY AT HOME with the Virtual Studio!!

domain: artistic


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The Sokoto State Government under the leadership of Rt. Hon. Aminu Waziri Tambuwal has prioritizes provision of Primary Healthcare service in Sokoto since its inception in 2015 to date.
The Sokoto State Deputy Governor, Hon. Manir Muhammad Dan’iya who’s also the Sokoto state chairman on Polio Eradication and Routine Immunization confirmed this in Sokoto when Sokoto recieved Executive Director, and Chief Executive Officer, National Primary Healthcare Development Agency, Dr. Faisal Shu’aib and his team for an audience.
Hon. Manir Dan’iya who also oversees Ministry for local government said from 2015 to date alot was sank for the upliftment of primary healthcare across the 23 local councils in Sokoto.
Hon. Dan’iya said Ministry of Health in partnership with Primary Healthcare Agency, the 23 local government councils and the Sultanate Council are working 24/7, 365 a year to see that sokoto people especially those residing in the rural areas get ultra health treatments within their locality.
Hon. Manir said as per as he knew, Sokoto state government has done its best on its counterfunding funds with local and international agencies and foundations to see sokoto has reached top spot in health provision to its citizens.
He said UNICEF, UN, EU, Gates & Melinda foundation, Dangote Foundation and others are all testimony to the zeal Sokoto State Government under Tambuwal is exhibiting to that direction.
The Deputy Governor noted huge efforts of National Primary Healthcare Center for focussing its satellite on Sokoto so as to meet up with best global practices.
He later told the ED that all his observations are noted for urgent intervention from the State Government so that the gaps identified will be filled.
Earlier the Executive Director, and Chief Executive Officer, National Primary Healthcare Development Agency, Dr. Faisal Shu’aib said they were in Deputy Governor’s office to brief him on the outcome of the 2 day meeting between Sokoto State Government, National Primary Healcare Development Agency and donor agencies on the challengies, way forward and observations on the activities of Sokoto state primary healhcare in the state.
Some of the points worth taking urgent action tabled by the ED were issues of remuneration of the staff in LGs, low turnout of Covid-19 vaccinations in LGs, increase in the rate of maternal mortality and increasing of pockets of resistance
of children vaccinations.
The ED hoped Sokoto will fight aggresively on the points raised so that Sokoto will be ranked high among other states in terms of provision of healthcare in Sokoto state.
The ED team at the audience to Deputy Governor include WHO Deputy Country Representative in Nigeria, Dr. Alex Chibani, and UNICEF Chief of Health Country Officer in Nigeria, Eduardo Celades.
By: Abdulfatai Abdulsalami, Sokoto


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US Air Force Academy Class of 2019 inprocessing day
A basic cadet training cadre member provides direction to basic cadets as they leave the U.S. Air Force Academy's Doolittle Hall and head for the cadet area in Colorado Springs, Colo., June 25, 2015. More than 1,000 young adults processed into the Academy and began BCT as members of the Class of 2019. (U.S. Air Force photo/Jason Gutierrez)
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World Association of Zoos and Aquariums is organizing a worldwide “Thunderclap” to support the International Day for Biological Diversity on the theme “The Pyramid of Life”
The Biodiversity is Us project wants to make as much noise as possible this year to raise awareness on biodiversity loss. What makes this year so special? WAZA prepared animated short just over 1-minute-long titled “The Pyramid of Life”. The animated short will premiere on May 22nd 2016.
The message? The Pyramid of Life illustrates the importance of all life on our planet. Whether we look at it from the top, or from the bottom of the food chain, our lives depend on the diversity of life on earth!
WAZA Needs Your Help!
What is a ‘thunderclap’? Thunderclap is a “crowd-speaking” platform that lets individuals and organizations rally people together to spread a message. On Thunderclap, backers donate tweets and social media posts rather than money. Think of it as an “online flash mob.” Join our Thunderclap this year and you and others will share the message to speak up on behalf of Biodiversity, on the 22nd of May (World Biodiversity Day) via Facebook and Twitter.
Please sign up today (and better yet, share this information with your friends and colleagues) to help them reach our goal of at least 100 individual signatures. It will only take a minute of your time.
The Thunderclap will be sent out on 22 May 2016. CLICK HERE TO SIGN UP NOW: http://thndr.me/pZkWR7


Audi will reportedly introduce a Quattro successor in 2015. Learn more inside
Audi will reportedly introduce a Quattro successor in 2015.
Being developed under the Q35 codename, the model will slot between the TT and R8. Unlike the concept, the production model could be to be a crossover-like coupe with two doors and four seats. It is slated to have short overhangs, a flat roof and an aggressive front fascia. We can also expect bulging fenders, LED lighting units and 20-inch alloy wheels.
Power will likely be provided by a turbocharged 2.5-liter five-cylinder engine with 380 PS (279 kW / 375 hp). It should be connected to an S tronic dual-clutch transmission which could enable the model to accelerate from 0-100 km/h in just over four seconds.
The car could be unveiled on the Quattro's 35th anniversary (thus the Q35 name) in March 2015. Production is pegged at 10,000 units annually.


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is a highly stylish lady out for a stroll with her two dogs (Borzoi or Russian Wolfhounds) and the entire figurine measures 12 inches high x 11 inches long. This is a heavy piece and made of some type of hard plastic, possibly poly resin material. It looks like it is supposed to simulate a wax figurine by the color and texture of it and is very detailed. I love the big floppy hat and the whispy clothing...very seductive with her "come-hither" expression! The piece is in great condition although t are some rough edges from the mold...and t is a small blemish (light spot) to the left of the womans mouth. The only marking is on the bottom and it says "Mexico", so I'm not sure of the age...but probably from the 70's or 80's. The style represents the early 1900's, so this would be a perfect addition to your art nouveau or Victorian decor.....My mission is to sell mostly vintage, antique or fun stuff with NO RESERVE...EVER...and all listings start at $9.00 or less, regardless of the market value. I'm a ZIPPY shipper and wrap everything with love and care. I offer a 100% money back, no questions asked guarantee, so get to bidding like t's no tomorrow! (AND HAVE FUN)!! Please feel free to ask any questions...and thanks for looking - Vicki
Items in the Worthopedia are obtained exclusively from licensors and partners solely for our members’ research needs.

domain: hobby


Hawk Harrelson called this one a "LuLu Jim Dandy." That in itself deserves a seperate post; along with every other Hawkism. The White Sox took the first game of their series with the Devil Rays 3-2 down in St. Pete.
John Danks got his first victory of the season following a no decision back in Chicago. Danks was excellent, knocking out eight Rays batters, while allowing one run in six solid. Carlos Pena was responsible for Danks only mistake, a homer with one out in the sixth. It was the only run Danks has allowed in 12 innings this season. Danks improved his record to 4-1 against Tampa Bay. All the victories coming in Tampa.
It was the bats that were most frustrating to watch. The Pale Hose were 3-13 with runners in scoring position and only advanced a runner past home plate one of those times. Failure to advance runners and capitalize on runners in scoring position is something the Sox will need to address if they intend on contending. It was power that lifted the team once again. Jermaine Dye (3) homered off Tampa Bay starter Jeff Nieman (0-2) in the second inning. It was homer number 140 for Jermaine, since joining the White Sox in 2005. The Sox tagged the Rays pitchers for 14 hits, while only scoring three times. Josh Fields' infield single in the ninth inning turned out to be the difference. Fields entered Thursday night's game batting .333.
Tampa Bay threatened in the bottom of the ninth. With runners on second and third, with two outs, Bobby Jenks got Gabe Gross to hit into a 3 unassisted. Bobby Jenks earned his third save.
Following the end of the 3:10 game, Hawk belted out MERCY and THIS BALL GAME IS OOOOOVER; then added "This was a LULU JIm Dandy of a game."
Attendace at Thurday's game drew only 13,803. This was a home opener.


What improvements did Tampa make to prevent pedestrian accidents?
Tampa’s Vision Zero program has helped reduce traffic fatalities in the city and received national praise for its effective use of federal funds to create structures that have helped prevent pedestrian accidents and other types of motor vehicle accidents in Tampa.
"While even one death is too many, we've seen a significant reduction in traffic fatalities thanks to our commitment to Vision Zero,” Tampa Mayor Jane Castor said in a statement published recently by Tampa.gov. “These numbers show that our efforts are making a difference. We are determined to continue leading the way in smart, data-driven infrastructure improvements."
Vision Zero Program in Tampa – what is it?
As the name suggests, the goal of Vision Zero Tampa is to reduce the number of traffic fatalities in the city to zero. “Even one deadly crash is too many,” the Vision Zero Tampa website says. “Vision Zero is the City of Tampa’s effort to eliminate all roadway deaths and life-altering injuries while increasing safe, healthy, equitable mobility for all.”
Recent Vision Zero improvements in Tampa
From 2022 to 2023, Tampa received $22.6 million in federal grant funding as part of the Infrastructure Investment and Jobs Act. These funds were given to Tampa in an effort to transform the city “towards safer and smarter streets,” according to Tampa.gov.
In particular, some of these funds were spent on “Quick Build” projects, which are city infrastructure improvement projects that can be built quickly and rapidly. In particular, protected bike lanes were built on Cass Street, along with additional bike lanes on The Avenida Republica de Cuba (14th Street).
Future infrastructure improvements slated for Tampa
Along with the recent protected bike lanes built in Tampa, city officials plan to build a total of 17 “Quick Build” projects by 2027 along with other “larger-scale endeavors” by 2028, according to Tampa officials quoted by Tampa.gov.
One future Quick Build project slated for Tampa includes creating a protected bike lane on Cleveland Street between Willow Avenue and Parker Street, according to Vision Zero Tampa’s description of the infrastructure improvement project. In particular, the website notes:
“The Vision Zero Action Plan identified Cleveland Street as part of the City's High Injury Network. The High Injury Network is the network of roads where the majority of the deadly and life-altering injury crashes occur. This project proposes reallocating a vehicle travel lane to create a parking separated bike lane.”
Pedestrian fatalities decreased dramatically in the Tampa area
Recent infrastructure improvements in the Tampa area have made a dramatic impact by helping to reduce the number of fatal pedestrian accidents. In particular, pedestrian fatalities in the Tampa-St. Petersburg-Clearwater metro area decreased to 53 deaths in 2023 compared to 77 deaths in 2022, according to Tampa.gov.
This decrease in pedestrian fatalities was critical since the Tampa-St. Petersburg-Clearwater metro area was ranked the the fourth most dangerous metropolitan area in the country for pedestrians in 2022.
Injured pedestrians have legal rights
Pedestrian accidents in Tampa or another part of Florida might seem straightforward at first. This is especially true if a driver clearly broke the law and hit you while you were crossing the street. But many straightforward cases often turn into complicated legal battles. This is because there’s often a lot of money at stake. Rather than simply paying injury victims the money they deserve; many insurance companies do everything they can to reduce or deny injury claims.
An experienced Tampa pedestrian accident lawyer at Armando Personal Injury Law can help you every step of the way. We know how the legal system works in Florida when it comes to pedestrian accidents. And we will do everything we can to demand the money you deserve.
Get a law firm that isn’t afraid to stand up to the insurance company and fight for you. Contact us and schedule a free case evaluation. Our office is located on East 5th Avenue in Tampa, and we work on a contingency fee basis. That means you only have to pay us if we secure a financial settlement or verdict for you.


- President Extends COBRA Subsidy under New Department of Defense Appropriations Act
- February 11, 2010
- Law Firm: Ford & Harrison LLP - Atlanta Office
On December 21, 2009, President Obama signed legislation extending the COBRA premium subsidy originally established under the American Recovery and Reinvestment Act of 2009 ("ARRA"). Under the ARRA, only individuals who were involuntarily terminated and who lost group health insurance coverage before December 31, 2009 were eligible to receive the subsidy. Moreover, the subsidy was only available for nine months of coverage.
The new legislation extends federal COBRA health coverage cost subsidies for 6 additional months for a total of 15 months of subsidized coverage. The extension applies to those COBRA beneficiaries whose nine-month premium subsidy under the ARRA had expired. The legislation also extends the qualifying event deadline to February 28, 2010. The legislation actually amends the ARRA provisions that required terminated employees to have been eligible for COBRA coverage by December 31, 2009, and now clearly says that the terminated employee only must have been terminated by December 31, 2009, even if COBRA eligibility isn't effective until some time in 2010. Although the December 31, 2009 deadline has been amended, the result is the same: come February 28, 2010, the employees need not actually be COBRA-eligible, they just have to have been involuntarily terminated by that date.
In addition, the legislation gives beneficiaries whose subsidy expired and who didn't continue to pay the full unsubsidized premium the opportunity to receive retroactive subsidized coverage. For example, a beneficiary whose nine months of subsidized coverage ran out November 30, 2009 and who didn't pay the unsubsidized premium for December 2009 now has the option to pay his or her 35 percent share of December's premium in January 2010 and, upon doing so, would receive COBRA coverage for December.
This legislation requires employers to notify current and future COBRA beneficiaries of the new 15-month premium subsidy. Additionally, it permits employers to offset future COBRA premiums or issue refund checks for beneficiaries who "overpaid" their COBRA premiums by paying unsubsidized premiums but who are now eligible for retroactive subsidized coverage.
The entire text of the legislation, including instructions for retroactive payment of premiums and notification requirements, is contained in Section 1010 of the Department of Defense Appropriations Act 2010, available at http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=111&under;cong&under;bills &docid=f:h3326enr.txt.pdf.
The Bottom Line
Employers and plan administrators should notify current and future COBRA beneficiaries of the new 15-month premium subsidy, and current COBRA beneficiaries of their right to extend receipt of the subsidy. Employers should also contact their payroll administrators to determine the easiest way to offset future COBRA premiums or issue refund checks to beneficiaries that overpaid their premiums.


|Cde S.K. Moyo for Speaker|
|Wednesday, 23 March 2011 18:02|
The Zanu-PF Politburo has nominated Ambassador Simon Khaya Moyo as their candidate for the post of Speaker of the House of Assembly.
The post that fell vacant following the nullification of the election of Mr Lovemore Moyo of MDC-T by the Supreme Court on the 10th of this month.
According to the Zanu-PF Secretary for Information and Publicity, Cde Rugare Gumbo, it is now the battle of the two Moyos; MDC-Tâ€™s Lovemore and Zanu-PF National Chairman, Cde S. K Moyo.
Interestingly, both are chairpersons of their respective parties.
Cde Gumbo said the Zanu-PF Parliamentary Caucus also met this afternoon and agreed to go with the recommendations of the Politburo.
Meanwhile, Cde Rugare Gumbo was nominated to the Senate to replace Vice President John Nkomo, while Cde Oppah Muchinguri will replace Vice President Joice Mujuru in the House of Assembly.
They will be sworn in at a date to be fixed by the Head of State and Government and Commander-in-Chief of the Zimbabwe Defence Forces, President Robert Mugabe.
Read also: Speaker election postponed


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Starting Thursday night, the Contemporary Youth Arts Company takes on Thornton Wilder’s classic play, Our Town. This Pulitzer-winning play about life in the village of Grover’s Corners has become a staple of American theater, and is read in classrooms to this day.
Our Town has also been a major influence on the work of our local master playwright and the director of this production, Dan Kehde. His own work, “Good Night, Grover’s Corners” is a prime example of this.
Describing this play is a bit of a challenge. So many people know it by heart. I will simply strongly urge you to see what, I’m certain, will be a thoughtful production, with an excellent cast. The date, time and ticket information is in the graphic above.
Our Town will feature Nik Tidquist, Mariah Plante, Michael Tighe, Matthew Connelly, Beth Chambers, Siercia O’Brien, Patrick Felton, Maddy Ranson, Caitlin Moore, Kat Johnson, Leon Alexander, Austin Lowe, Neil Gandee, Lisa Gandee, Angel Gandee, Lauren Mallory, Olivia King, and Bob Bird as the residents of Grover’s Corners, New Hampshire.


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A few months back we discussed the pros and cons of mirrorless cameras vs DSLRs. Here are a few notes and helpful links from that discussion.
Mirrorless vs. DSLR cameras:
Mirrorless vs DSLR
A DSLR camera is a digital camera body that allows light to enter a single lens where it hits a mirror that reflects the light either upwards or downward into the camera’s optical viewfinder (OVF). DSLR stands for Digital Single-Lens Reflex.
When you press down on the shutter, the mirror flips up out of the way. The shutter then slides open, and light coming from the lens takes a straight shot to the imaging sensor where a photograph is made.
A mirrorless camera is a digital camera that doesn’t have a reflex mirror. In a mirrorless, there isn’t an optical viewfinder and the imaging sensor is always exposed to light. It gives you a preview of the image on the electronic viewfinder (EVF), which is often an LCD screen on the back of the camera.
Video on the differences: Mirrorless VS DSLR Cameras | What's the Difference? (2019 Edition) - YouTube
Pros of DSLRs
Better battery life (though this is narrowing)
Larger lens selection
Faster autofocus (generally, although also narrowing)
Cons of DSLRs
Big and bulky
Slower shooting speeds
DSLRs offer 4k or Ultra HD video only for higher-end models.
Pros of Mirrorless Cameras
Light, small and compact
Less moving parts, they’re quieter than other cameras
No flicking mirror means no camera shake
Reliable video mode
The electronic viewfinder can be used in video mode, while the viewfinder on a DSLR cannot. Also, high resolution is built into most mirrorless even if they’re on the low-end, quality wise.
Cons of Mirrorless
Battery life (though getting better! See more on this below)
Ergonomics (small, maybe too small for anyone with big hands)
Limited lens selection (again, getting better! But a fair point)
Electronic viewfinder - limited in low light environments
Here are some of the mirrorless cameras that we mentioned during the discussion by artists Nanci Frace-Vaz and Slade Wheeler:
SONY A7 – III (mirrorless) https://www.amazon.com/Sony-Full-Frame-Mirrorless-Interchangeable-Lens-ILCE7M3/dp/B07B43WPVK/
SONY A3000 (mirrorless) https://www.amazon.com/Sony-Mirrorless-Digital-Camera-18-55mm/dp/B00EH5UGR6/
Sigma 60mm F2.8 EX DN Art (Black): https://www.amazon.com/Sigma-60mm-F2-8-Black-Micro/dp/B00CMRTVFE/
Links to some other discussions that mention this issue:


OTTAWA — The governor of the Bank of Canada says the resource sector ought not to be deterred from making long-term investments despite the sharp price drop for many commodities.
In prepared remarks for a speech Monday, Stephen Poloz said investment decisions made years ago by players in the commodities sectors were no mistake, even though prices have dipped in recent months.
Poloz’s address reminded its audience how the Canadian economy had benefited significantly in recent years from rising commodity prices. As an example, he highlighted how the price of copper had tripled while oil and nickel doubled between 2008 and 2010.
“We shouldn’t ignore the resources that we have been blessed with,” Poloz said in the address, to be delivered to a group called Calgary Economic Development.
“Without those investments (years ago), we would never have been able to capitalize on the higher prices, which boosted Canada’s aggregate income.”
His speech comes on the heels of a difficult period for the economy, which contracted over the first two quarters of 2015 and pushed Canada into a technical recession.
The steep drop in the price of crude oil, which closed just below US$47 a barrel Monday after falling from a high of US$107 last year, has been slapped with much of the blame for the shrinking economy. The economy has also been hindered by slower than predicted rebounds in other sectors.
As a result, the oil-price shock forced experts, including the Bank of Canada, to downgrade growth projections for the country.
The gloomier economic conditions have also become a focal point for much political debate in the current federal election campaign.
Business leaders in the oil industry told the central bank earlier this year they would be cutting investments by about 40 per cent because of the steep price drop, which has not recovered as quickly as anticipated, Poloz said.
He added that in recent weeks these companies were still revising their longer-term forecasts for the price of oil.
The resource sector, he said, is still adjusting to the tougher conditions — a process he believes will take “considerable time.”
None of the volatility, however, should deter Canadians from continuing to seek benefits from the country’s resources, Poloz said.
“We’ve adjusted to rising prices — we can adjust to falling ones,” Poloz said in the speech being delivered in a province where, he noted, resources make up more than a quarter of economy.
“While an abundance of raw materials may complicate the management of companies and the conduct of economic policy, it’s far better for a country to have resources than not to have them.”
“Even when prices are falling, as they have been recently, our endowment represents a store of value and a source of future riches.”
Follow @AndyBlatchford on Twitter.
Andy Blatchford, The Canadian Press


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Metabolic syndrome, diabetes, poor cognition, and dementia in the Caerphilly prospective study.
Creavin ST., Gallacher J., Bayer A., Fish M., Ebrahim S., Ben-Shlomo Y.
We have examined whether metabolic syndrome is associated with intermediate risk of impaired cognition between people with and without diabetes. Men aged 45 to 59 years were identified from Caerphilly in South Wales, United Kingdom. Participation rate was 89% (41% of the original cohort) and 2,512 men were examined in phase one from July 1979 until September 1983. Follow-up examinations occurred at four intervals until 2004 when 1,225 men participated. Participants were categorized on the basis of their exposure to metabolic syndrome not diabetes (MSND) and diabetes (with or without metabolic syndrome) at each of the first three phases. Neuropsychological outcomes and clinical diagnosis of cognitive impairment not dementia (CIND) and dementia were assessed at phase five. The prevalence of MSND increased from 1% to 5% and for diabetes from 3% to 9% between phase one and phase three. 15% of participants had CIND and 8% dementia. People with diabetes, but not those with MSND, at phases one, two, or three had poorer cognition at phase five (adjusted β coefficient AH4 -4.3 95% CI -7.9, -0.7; phase two: -2.5 95% CI -4.7, -0.3; phase three: -2.3 95% CI -4.2, -0.5). The adjusted odds ratio (phase one) for diabetes and CIND was 4.0 (95% CI 1.4, 11.5) and dementia 0.61 (95% CI 0.07, 5.37). After adjustment, higher systolic blood pressure was the only component of the metabolic syndrome associated with worse cognitive outcomes. Diabetes in mid-life, but not MSND, is associated with impaired cognition and increased odds of CIND in later life.

domain: literature


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McKinley Investment has one of the most sophisticated private investment fund practices in the industry. The success of our practice is based on three tenets:
Our purpose is to help clients to make intelligent investments on intelligent terms. To this end, we are constructive in all our dealings with others. We are committed to excellence in service by being responsive to client needs and understanding the time-sensitive nature of opportunities. We constantly develop our practice through innovation to provide our clients with access to leading-edge solutions and strategies.
Building on these values, we bring an unsurpassed depth of experience and a distinctive approach to providing astute advice and risk assessments, practical solutions, and first-class service for our clients.
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Handling your assets is a large feat that requires meticulous planning and a hefty window of dedicated time. As a business owner, you know the value of sound financial management, but that doesn’t mean you always have the time to spare. With so many other tasks and duties on your plate, it’s easy for your investments to fall lower on the priority list.
If you’re looking to lighten the load and shift your financial responsibilities to trusted professionals, McKinley Investment is the investment firm you need to get back on track. Our skilled advisors offer financial advice and investment management services so that you can focus your time and energy on growing your business.
At McKinley Investment, we seek to build meaningful relationships with our institutional clients. We concentrate on developing a deep understanding of your goals and offer customized services at each stage of our engagement to ensure that our people and processes complement the culture and values of your organization.
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Investment consultants are finance professionals who offer investment advice and strategies to clients to help them achieve their financial aspirations. Investment advisors can evaluate a client’s financial standing, monitor investments, and devise a strategic plan to help them reach their objectives from small businesses to large corporations.
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Our investment advisors have been providing clients with detailed and efficient financial advice for decades. We strive to optimize your assets, manage tax consequences, reduce costs, and eliminate risks with our customized plans. Our qualified team has created specialized solutions for a wide array of industries and clients, including:

domain: finance


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Hospitals working to stop spread of flu virus
Hospital releases suggestions of how to minimize the spread of winter viruses
Hospitals in the Ottawa area are asking for the community's help to reduce the spread of infection as the flu season came early this year.
CHEO, the Ottawa Hospital, Montfort, Bruyère, the Royal and the Queensway-Carleton Hospital put out a joint news release on this issue on Tuesday.
"Hospital patients are at greater risk for infection as their bodies are already working hard to recover from their illness or injury," they said in the release.
"When germs are brought into the hospital from well-meaning family or visitors, it puts all hospital patients at risk."
Staff at the hospitals will be stepping up prevention and monitoring during the peak of the season, which is expected to hit in the new year.
They're asking people to:
- Avoid visiting patients if you have a runny nose, cough, fever, vomiting or diarrhea.
- Limit the number of people who accompany patients to the emergency department and outpatient clinics.
- Clean your hands when you come and go from the hospital and patient's room.
Hospitalizations from influenza are already higher than expected, they said.
Additionally, there were two outbreaks of gastroenteritis in Ottawa daycare centres, according to Ottawa Public Health. The city is urging anyone who may have come in contact with children at the daycare centres to wash their hands often and disinfect anything they may have touched.


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Coffs student's work may aid stroke sufferers
IMAGINE a world in which your brain only processes half of what you see - leaving you able to visualise only half of what's on your dinner plate or only half the numbers on a clock.
That's the reality for people suffering spatial neglect, a condition that can affect stroke victims and other people who have received an injury to the right hemisphere of the brain.
Southern Cross University PhD student Russell Reid, who is undertaking research through the Department of Psychology at the Coffs Harbour campus, has been invited to the University of Milan-Bicocca in Italy, to work on the development of a new tool to be used in assessing this condition.
“Up to 80 per cent of people who have had a stroke will have symptoms of spatial neglect. Most recover that function fairly quickly, but some people are afflicted permanently,” Mr Reid said.
“Men who have this 'neglect' will shave half their faces and women who put on make-up will only do half their face. Physically sufferers of neglect can see what they neglect but they cannot attend to it - salient and important information is just not being processed.
“For these people they forget that space exists and at the moment there's no real treatment.”
Mr Reid first began investigating this condition while completing an Honours research project, creating a visual simulation tool which he now hopes can be developed into an assessment tool for clinicians.
He has been invited to work with Associate Professor Roberta Daini, from the University of Milan-Bicocca, one of the leading researchers in this field.
“People who have this condition learn strategies for dealing with static objects, such as turning their dinner plate around so they see both halves. The goal of this project is to see whether their ability to move through space is still affected,” he said.
“This collaboration will provide an opportunity to test this simulation on people suffering from this condition,” Professor Rick van der Zwan said.


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October 28, 2009
The Railroad Tycoon who Built Chicago: New Biography of William Butler Ogden
In a letter from Paris, dated 22 August 1877, Mary Todd Lincoln, the president’s widow, wrote, “This morning, in a New York paper of Aug. 8, I read the announcement of Mr. Wm. B. Ogden’s death. In former times, he was a very prominent citizen of Illinois.” Mr. Lincoln, of course, was that prairie lawyer from Illinois who was both a congressman for the people and counsel for railroads, who poured out his life to save the Union. Mr. Ogden was a businessman from a small town in Western New York who through great vision, the force of a powerful personality and amazing determination in the face of staggering setbacks, helped extend and build that Union. As Jack Harpster, author of a new--and given the scope of his accomplishments,almost inconceivably, FIRST--biography of Ogden, epitomizes William Butler Ogden was a builder. At sixteen, as his father lay paralyzed in bed, he built the family lumber and woolen business into an ever increasing size; he later built his brother-in-law’s land investments in Chicago into a greatly profitable real-estate concern; he helped build Chicago from a muck-mired frontier garrison and trading post into “nature’s metropolis”. He was a backer and guiding light of the Galena and Chicago Union Railroad as well as the Chicago & North Western. He was first president of the Union Pacific. He had his hands in northern lumber, Pennsylvanian iron, and there was scarcely a public project, a civic organization a plan for development in Chicago that Ogden was not a president, a trustee, a supporter, a silent partner. Even in retirement he was working to help develop public transportation into the upper reaches of New York City.
While there are streets in Illinois, Nebraska, Wisconsin and New York, a medical center in Elmira, a library western New York, a stained glass window in an Omaha Cathedral, and an elementary school in Chicago all carrying Mr. Ogden’s name, it has been Mr. Harpster’s destiny to write what must be the definitive telling of his story. With a skilled hand and very cogent analysis, Harpster as biographer weaves the growth of 19th Century America in size, technology and outlook, with the struggles and achievements of William B. Ogden’s life so straightforwardly that it belies the immense amount of research and study he has undertaken. Time and again Ogden built a great financial empire to have it washed away by the periodic collapses of national economy or the devastating destruction of natural disaster. Time and again Ogden yield not to depression or despair but turned even stronger efforts to rebuilt and expand. The power of Ogden’s vision or his ability to sway both a New York legislature or group of Wisconsin farmers out to lynch him, reminds us of the vision of those who have preceded us and what is possible in our land now and in the future. This remarkable story is recommended reading for not only those of us concerned with history, urban development, railroading, and business, but for all concerned with the human spirit. Five stars.
--Raymond F. Kearney
The Railroad Tycoon Who Built Chicago:
A Biography of William B. Ogden
By Jack Harpster
Southern Illinois University Press, 2009
NOTE: My sincere thanks to Journal guest blogger Ray Kearney for allowing me to publish his review.
Posted by Chicagobookbabe
Labels: William Butler Ogden

domain: library


Dr. Raja is a frequent expert commentator on clinical psychology topics. She provides psychological insights on serious breaking news, including coping with terrorism, sexual assault, domestic violence, gun violence and other traumatic events. As a mother of two girls, she also addresses parenting, health,and wellness issues related to today's busy families. A complete portfolio of her media appearances on national and local networks can be found on her YouTube Channel. You can also view her on CBS-2 Chicago for regular guest segments.


BOISE - The Boise State football team's final regular season game on Nov. 30 vs. New Mexico will start at 8:15 p.m. and be televised on ESPN2, the Mountain West Conference and ESPN announced Monday.
It will be Boise State's fifth game this season that's started after 8 p.m. MT and the third in a row. The Broncos have only had one game start earlier than 6 p.m. this year.
Boise State will play at San Diego State at 8:30 p.m. on Saturday on CBS Sports Network. They are coming off a 48-7 win over Wyoming that also started at 8:15 p.m. and aired on ESPN2.
If the Broncos can beat San Diego State on Saturday, a win vs. New Mexico would put them in the first Mountain West championship game on Dec. 7. That game, likely a rematch at Fresno State, would start at 8 p.m. on CBS.
Late starts this season:
Aug. 31, at Washington, 8 p.m., Fox Sports 1
Sept. 28, vs. Southern Miss, 8:15 p.m., ESPNU
Nov. 16, vs. Wyoming, 8:15 p.m., ESPN2
Nov. 23, at San Diego State, 8:30 p.m., CBS Sports
Nov. 30, vs. New Mexico, 8:15 p.m., ESPN2


The foreign minister also sounded determined to ensure the blockade on Qatari airspace is proven illegal as soon as possible under global law.
Qatar is home to the biggest US military base in the Middle East.
"Qatar is willing to sit and negotiate about whatever is related to Gulf security", he added.
That helped spark the crisis, which began June 5 when Saudi Arabia, the UAE, Bahrain and Egypt cut diplomatic ties and started trying to isolate Qatar from the rest of the world.
Qatar's Central Bank said yesterday banking transactions at home and overseas were continuing normally despite the diplomatic crisis which has seen several Gulf countries sever ties with the emirate.
"The statement from Federation Internationale de Football Association was seen as welcome", said the insider.
"I have urged all sides to refrain from any further escalation and to engage in mediation efforts", he said.
Qatar though has received the support of FIFA president Gianni Infantino, who said on Sunday that the emirate would remain as 2022 hosts, and that football's governing body does "not interfere in geopolitics".
Smith slams Australia's bowling performance after draw
Tamim Iqbal's 95 was the highlight for Bangladesh , who are winless and face New Zealand in their final group tie. Left-arm fast bowler Mitchell Starc was the pick of the bowlers as he picked up four wickets for 29 runs.
In an interview broadcast Monday by CNBC, Ali Sherif al-Emadi said there are some challenges, but that Qatar is "business as usual".
But Al-Emadi said there is no such crisis.
The discussion also included telephonic conversations between US President Donald Trump, Turkish President Recep Tayyip Erdoğan, and French President Emmanuel Macron. Anwar Mohammed Gargash, UAE Minister of State for Foreign Affairs, said on his twitter account. It quotes the prime minister as saying he hopes the dispute between Qatar and its Arab neighbors will be resolved soon.
Sheikh Mohammed bin Abdulrahman Al Thani said Monday that Qatar is in contact with global aviation authorities and legal organizations as it tries to fight back against moves by Saudi Arabia and its allies to cut off its land, air and sea access.
Qatar Airways chief executive Akbar al-Baker acknowledged the measures in a statement that accompanied the company's annual report released on Sunday (11 June).
Qatar's new and state-of-the-art Hamad International Airport in Doha serves as a major transit hub for some 37 million passengers a year, largely between Europe and Asia.
US Secretary of State Rex Tillerson has been conciliatory - calling for an immediate end to the blockade.
The small peninsula, which is connected to Saudi Arabia, is heavily reliant on imports for food and before it was cut off from its neighbours brought in 80% of its supply from surrounding Gulf countries.
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ISLAMABAD: Balochistan government has decided to initiate various development and public welfare projects in Gwadar, besides expediting the work on water projects to resolve the longstanding issue of drinking water in the city.
Talking to APP, an official of the Balochistan government said that it was the provincial government plans to initiate the development and renovation work to improve the old structure of the Gwadar city and added the provincial government had allocated a huge amount to construct and rehabilitate the roads in the area.
He said the government would construct East-bay Expressway as the road is the main artery of Gwadar Port through which the entire traffic of port will flow.
The objective of East-bay Expressway is providing primary connectivity of the port with the network of National Highways.
With the construction of roads, the fishermen would get easy access to the port and would get swift route to transfer their hunted fish to the market, he added.
He said local and foreign investors would be welcomed at Gwadar Port Free Zone to establish their fish processing plants as a Chinese company was already establishing a Cold Storage and Fish Processing Plant in the zone.
The Balochistan government would restructure and establish latest hospitals in Gwadar to ensure health facilities to the people.
He said the previous governments had developed the city on papers and nothing was done on ground. Today the situation was different. The incumbent government had finally prepared the Gwadar Master Plan with the consensuses of all the stakeholders, including the Gwadar Development Authority (GDA) and the local parliamentarians.
Under the Gwadar Master Plan, he said, the local population would not be dislocated as the old city would also be developed.
He said Gwadar was facing a power crisis as at present it was getting limited electricity supply from Iran. The area would be connected with the National Grid within two years, he added.


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Solo by Dave Sumner
Live by Donald Elfman
Live by Jim Santella
Live by John Kelman
Come Together by Jack Bowers
Come Together by Mark F. Turner
Arise by C. Michael BaileyMore articles about Lynne Arriale
TJ McReynolds added this event on 2013-03-13 20:07:37.
Dazzle Restaurant and Lounge
Fri, March 29, 2013
7 & 9pm
Solo Piano Thursday night.
Trio Friday night.
“Lynne Arriale’s brilliant musicianship and bandstand instincts place her among the top jazz pianists of the day.” (The New York Times)
Lynne Arriale’s remarkable career is graced by a rare commitment to authenticity and vulnerability defined by careful craft and high artistic standards. It is precisely this willingness to remain so emotionally exposed that makes her performances so accessible to music lovers of all kinds.
If the nature of jazz is “reinvention,” then pianist/composer Lynne Arriale has truly led the jazz life, following a personal and musical journey throughout which she has reinvented herself, her craft, her artistic direction...
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It’s exactly 21 years today when more than a dozen soldiers accused of a coup plot were summarily executed by The Gambia’s military junta. The ‘military with a difference’ sadly lacked the balls to tell Gambians the list of coup suspects. Only the alleged leader Lt. Basiru Barrow was named. What has become our country’s first government-anointed massacre story remains shrouded in mystery. And to make matters worse, the families of massacred soldiers are not talking about the 11/11 event.
We would have known the true story had executed soldiers emerged from their graves. That has never happened anywhere. The onus now is on those who knew the story in toto to tell us exactly what happened on that fateful night at Fajara Barracks and Brikama range. We as a society has a real problem when we cannot tell our own story, especially the one that disvirgins our nation. It is an irony that most of the 11/11 storytellers were traumatized and ultimately had their memories faded. We give kudos to the few soldiers for publicly sharing thier side of the cold-blooded event.
Of course, not all the families remain tight-lipped. The father of the late Lt. Gibril Saye remains a hero for challenging the lies of the ruling junta. We stll have memories of how Pa Amadou Saye confronted the junta over its cooked up story. The dynamic would have changed had the families Lt. Basiru Barrow, Lt. Abdoulie Dot Faal, Lt. Bakary Manneh and others done the same. In that case, the anger-laden Gambian people would be in solidarity with the families who had their loved ones executed and denied the right to a fitting burial.
The families may be crying in silence, which is understandable but that should not stop them from sharing the memories of their loved ones with the public? This can be done by taking a minute’s silence, organized prayer sessions or write articles promoting their vision. A simple poem on how they are loved and missed will immortalise them. All these create new holes of disturbance and guilt in the hearts of their killers.
Remaining silent is not a winner here since it smoothens the hearts of the cowards loaded with fears of being busted. Clearly, all those who play a part in these heartless and unjustifiable executions will forever be hunted by the nemesis they create. All the heartless people who either fired shots, directed, macheted or bury our soldiers alive will reap what they sow. The spirits of the innocent souls keep boggling their mind anytime they go to bed.
Most people expected President Jammeh to seek forgiveness from Gambians, especially for the 11/11 and April 10 &11 masdacres. He eluded the chance in July when he pardoned over 200 prisoners. But we were not surprised he didn’t because his ego wouldn’t allow him. How can the wounded families forgive and forget when they are denied justice, compensation and the government refuse to seek forgiveness? The chapter remains opened until the right thing is done: investigate the executions, prosecute those responsible and compensate victims’ families.
We at Kairo News and Radio join the families of 11/11 to remember the victims on a day that has left a permanent scar on our country’s image. We pray for the souls of the fallen soldiers to enjoy Eternal Bliss.
The late Lieutenant Lt. Basiru Barrow, Lt. Gibril Seye, Lt. Buba Jammeh, Lt/ Abdoulie Faal (Dot), Lt. Momodou Lamin Darboe, 2nd Lt. Bakary Manneh (Nyancho), Officer-Cadet Amadou Sillah, Sgt-Major Fafa Nyang, Corporal Basiru Camara and countless other soldiers were gone but their memories would remain.


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“At Butterball, we have made adjustments to our basic business model through more efficient practices and forecasting,” says CEO Keith Shoemaker. “I believe that our decisions to reduce volumes and alter production have made Butterball a stronger company with a very bright future.”
Dan Waters, general counsel for West Liberty, Iowa-based West Liberty Foods, is optimistic. “Things are going well for us right now,” he says. “When the economy first started to skid, there was a decrease in demand, and we cut back on production. But now, we’ve started ramping back up, and soon we’ll be back to full production. We’ve been using up our inventory, and they are declining.”
Navigating new regulations
Though the outlook is upbeat, challenges remain. Shoemaker points to a resolution introduced in Congress that would phase out the use of antibiotics for non-therapeutic purposes in food animals. “During a Congressional hearing in July, expert testimony was given stating there is no scientific consensus regarding the impact of antibiotic use in animal agriculture, yet [Congress continues] to write legislation,” he says.
The bill, entitled “Preservation of Antibiotics for Medical Treatment Act,” is currently in committee in the House, and as of early August had 119 co-sponsors in the House and 17 in the Senate. Some groups, such as the American Veterinary Medical Association, are actively pursuing the bill’s defeat. The Food and Drug Administration (FDA) also is studying the issue, and at the end of June issued draft guidance that recommended reducing the amount of antibiotics used in animal agriculture.
When the guidance was issued, Joshua Sharfstein, FDA’s principal deputy commissioner, said during a conference call with reporters, “This is an urgent public-health issue. To preserve the effectiveness, we simply must use them as judiciously as possible.” A comment period was opened for 60 days following the guidance’s issuance.
When discussing the resolution, Shoemaker doesn’t hold back. “Often, actions taken to institute new legislation, regulations and consumer preferences do not reflect science but are just reactions to misplaced perception,” he says. “I don’t like using clichés , but in this case, it is true. People do not understand where their food comes from or how it is produced.”
He advocates the turkey industry presenting a united front on this issue and being vocal to educate consumers as to how turkey is raised and processed. Butterball recently struck up a partnership with Weekly Reader magazine to get out its message. In addition, the Butterball Web site will include a new, educational “Celebrate Agriculture” feature that will be used in third- and sixth-grade classrooms in various parts of the country. “I’m excited about this program,” Shoemaker says, “because I feel that educating our youth as to where their food comes from is an important step in assuring the facts, and not myths, are believed.”
Eat more turkey
Promoting turkey consumption remains a priority for the industry, as well. Though Sherrie Rosenblatt, vice president of marketing and communications at the National Turkey Federation (NTF), acknowledges the recession “has been tough,” she, too, remains confident. “We hope more consumers will realize that turkey is not only a good-for-you product, but also a good economical choice.”
To that end, NTF has launched the “Upgrade It!” marketing campaign, which encourages moms to “upgrade” their protein choice to turkey. A large component of the campaign is an upgrade calculator, featured on eatturkey.com. For xample, consumers can click on a dish they might normally associate with another protein, such as ground beef in shepherd’s pie. Users who click on the menu item are shown how they can use lean ground turkey to enhance the nutritional profile of their meal. “It’s a way for busy moms to take things they would normally feed their families and change that protein to turkey,” Rosenblatt adds. She says NTF hopes to expand the campaign to include a wide swath of items for the breakfast, lunch and dinner dayparts.
New recipe ideas are a key component of Butterball’s push to increase consumer demand as is its long-standing direct-to-consumer phone line. The company has seen the popularity of its Turkey Talk-Line grow exponentially thanks to social media tools.
“We are now using Facebook, Twitter and bloggers to interact with our consumer and bring them…[information] to help them prepare delicious and nutritious meals,” Shoemaker says. Though the Talk-Line is most famous for its Thanksgiving turkey assistance, technological advancements have allowed it to encourage turkey consumption and inform consumers more than ever before.
After all, getting consumers to talk turkey is what everybody wants.
An appetite for deli meats
Turkey deli meat distribution grew 6 percent in 2009 to total more than 467 million lbs., according to a new survey from the National Turkey Federation. Some 43 percent of that product went to foodservice operations the 2009 Marketplace Survey noted.
This year, processors have introduced several new turkey deli-meat offerings, and foodservice operators are talking turkey with many new products, too. Garner, N.C.-based Butterball LLC introduced deepfried-flavored deli meats, including Thanksgiving Style Turkey and Honey Turkey. Those items, along with many others, such as the company’s Cajun Style Turkey Breast and Honey Roasted Turkey Breast, are certified by the American Heart Association as heart-healthy.
Tyson Food Service launched Tyson Deli Slices in May, and the line includes three varieties of Oven-Roasted Turkey Breast at varying quality levels, named Premium, Favorites and Basics.
Panini-style sandwiches are appearing on more restaurant menus, and the options often include turkey. In July, Cinnabon, which has 570 locations throughout the U.S., announced it would begin testing serving breakfast and lunch, including a smoked turkey panini. Carino’s Italian, a 70-plus-unit operation, introduced a new kid’s menu that features a turkey and mozzarella grilled panini.
According to NTF’s survey, foodservice sales account for 18 percent of turkey volume.
Alicia Karapetian is a free-lance writer based in the Chicago area.

domain: food


Hello, I've been using my Omen 880-150t desktop for about a year now.
I'm very satisfied overall but would like to improve a bit on the thermals. The liquid cooled CPU easily reaches mid 40s and the RTX 2080 ti reaches mid 70s quite frequently, and I think it partially has to do with the airflow of the casing. Tthere's really not much airflow - very minimal intake from front, top, sides, or the bottom, and only one case fan blowing out through the CPU cooler's radiator in the back.
Most commercially available cases would give you more ventilation or at least places to install more fans, but I just don't see it in the casing for 880. Does anyone know any way to improve the airflow or thermals on this unit (aside from opening up the side panel and blowing a fan into it - I don't think I can handle the dust build up)
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Gerbera: Everything YouNeed to Know
Have you ever put a bouquet of flowers together and found yourself limited because your favourite bloom only comes in a limited choice of colours! Don’t worry we have a solution - the Gerbera Daisy. If you’re looking for something that will stand out in your vase this spring, then you have to try these flowers.
Looking a bit like the middle sibling between the golden sunflower and the delicate daisy, this bloom is not one to shy away from. If you want something that offers a real zing then you’re in the right place. From fiery tones, all the way through to pastel hues there is something for everyone and this bloom simply shouts happiness.
So, why not gather up a glorious bouquet packed full of gerbera and present it to a friend who’s in need of a pick-me-up. They make a statement all by themselves, or consider mixing these blooms up with some lilacs, freesia and chrysanthemum for that perfect April birthday bouquet (the gerbera is the birth flower for this month).
Meaning & History
Also known as Transvaal, African and Baberton Daisies, these flowers have long been a firm favourite and they regularly rank in the top 10 of most popular flowers.
Although they may look like a thoroughly modern bloom, did you know the gerbera goes back in history and held strong significance for some of our ancestors? The Celts believed this simple bloom could bring balance to your life and that God would cover the ground with these blooms when a child died, while the Egyptians believed the flower was closely linked to nature (probably because the flowers always turn towards the direction of the sun).
So how did we end up with this flower sitting in our vases? It is believed the gerbera was first discovered in its native home in South Africa during the 1700s by Dutch botanist, Jan Frederik Gronovius. For some reason, although found by Mr Gronovius, he decided to name the flower after the doctor and botanist Traugott Gerber. As far as we know they had never met and no one is sure why he chose to do this. Whatever the reason, the name stuck.
It wasn’t until the early 19th century, a whole 100 years later after it was first discovered, that this divine flower found its way to our shores. It then took another 100 or so years for it to become a firm favourite when, in the 1970s, these flowers became a big hit. You can sort of see why, its looks and choice of colours certainly fit in with all those groovy, hippy vibes!
As you would expect from such a bright and joyful-looking flower, gerberas are often seen to represent positivity and cheerfulness. This sentiment is probably helped by the large range of happy colours they come in. However, this bloom goes much further than that and the flower also stands for innocence, purity and beauty (well, you have to agree they are pretty attractive!)
If you know anyone celebrating a 5th wedding anniversary then you must send a bouquet of these (the daisy is the traditional flower to celebrate a 5th wedding anniversary). Need some help deciding on the best colour to choose? The meaning of gerbera flowers varies depending on the colour of the flower and you might want to choose different colours to deliver the perfect message.
Types of Gerbera
If you’re looking to pick some gerbera it's worth knowing that the different varieties fall into four main categories.
Single gerberas are perhaps the most commonly available bloom and, as the name suggests, they are recognised by their simplicity of flower shape. A green centre is surrounded by a single row of long petals that do not overlap.
With double gerberas, the central disk is either green, black or red but unlike the single version. The petals form into two rows of overlapping petals which gives the flower head a fuller appearance. They are available with either long or short petals.
Crested Double gerbera again features two rows of overlapping petals. However, this variety also features an extra row of shorter, inner petals which don’t always match the colour of the outer petals. They certainly would look romantically decadent in a wedding bouquet.
If you’re looking for volume then you have to choose the Full Crested gerbera. This is the show-off in the group and features two rows of both inner and outer petals. In fact, it’s so brimming with petals, the first row often surrounds and covers the central disk.
If you’re looking for something a little smaller than the gerbera, you might want to try some germini. These blooms belong to the same family, so you get all the bright colours, but they are the miniature version – usually between 5 and 7cm. Germini flowers are the ideal choice for the arrival of a baby mixed in with alstroemeria or narcissi.
Gerbera Care Tips
The great thing about placing a vase full of gerbera in your home is that they don’t have a strong smell – ideal for people who are a bit sensitive to strong fragrances. They also last a long time in the vase – between 7 and 10 days.
To keep them looking at their best make sure you place them in a clean vase (they don’t like bugs) and fill it with a small amount of room temperature water, about 7cm high should do. Trim the stems by cutting diagonally with a sharp pair of scissors or secateurs. Now keep the temperature even – not too hot and not too cold. You should also avoid draughty areas and keep out of the full sun. Refill your water regularly, it helps to stop your gerbera from drooping.
Ready to bring the colour in? Get a bunch of these fantastic gebera and bring some happiness into your home or theirs.


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Night Hibiscus ring
Shipping calculated at checkout.
Each ring is a two day process of adding bits of dried hibiscus flower petals, gold leaf, and glass glitter flakes with resin. Resin must be added three times to get this 3D effect.
Rings are adjustable. They’re made of pewter with 24k gold electroplating and nickel free.


STATE COLLEGE -- Homecoming weekend is here and No. 8 Penn State must take care of business today against Michigan State if it wants to remain in the championship hunt, both in the Big Ten and nationally.
Summer has moved on. The game time temperature should be right around 50 degrees and it will get lower as the contest progresses.
But let's discuss the game.
The wideouts' impact. Penn State and Michigan State should be slinging it around. The Spartans' run defense is No. 1 in the country but their secondary was gouged by Northwestern quarterback Clayton Thorson last week. And MSU's running game is generating an average of 123 yards per contest.
So the expected return of wideout KJ Hamler should be a major boost for Penn State. He left the Ohio State game early in the fourth quarter with an apparent head injury.
On the Michigan State side, Felton Davis is a receiver to watch. He leads the Spartans with 23 catches for 374 yards and two touchdowns. Davis also posted a 12-181-1 line vs. Penn State last season.
Shane Simmons returns. Penn State's talented reserve end is suited up and expected to make his debut after missing the first five games with a lower-leg injury. Simmons can ease the workload of starting ends Shareef Miller and Yetur Gross-Matos.
Tommy Stevens' role. The Lions have to get their talented dual-threat backup quarterback more involved. He can be a factor as a runner, receiver and thrower. Stevens, slowed by injuries in the spring and summer, made his first 2018 appearance against Ohio State and lost 12 yards on three carries.
Trace McSorley record watch. The Lions' fifth-year senior has a satchel full of career and single-season marks. McSorley (8,418) needs 40 yards to pass Christian Hackenberg (8,457) for the Penn State all-time passing yardage mark.
Michigan State's Scott unavailable. Spartans veteran feature back LJ Scott, out since an early-season loss at Arizona State with an ankle injury, did not make the trip, per the Lansing State Journal.


EK Water Blocks has announced an immediate recall of its Predator 240 and 360 all-in-one liquid cooling systems, following the discovery that the loop isn't as sealed as promised and risks liquid leaking out.
Announced back in August 2015
, the Predator family makes up the company's first-ever all-in-one liquid cooling offering. Based around 240mm and 360mm radiators, with the latter available featuring a built-in quick-disconnect system compatible with the company's other liquid cooling products, the relatively low cost of the platform compared to building a custom loop plus EK's reputation in the liquid cooling industry led to considerable interest.
Unfortunately, early adopters appear to have been bitten by a serious design flaw. EK has confirmed that all three launch models of Predator system - Predator 240, Predator 360, and Predator 360 with Quick Disconnect - run the risk of leaking cooling liquid, potentially frying other components in the system.
As the company received reports of leaks, it initially believed the problem to be limited to a small number of faulty units. As failures mounted, however, EK has been forced to admit that it's a problem across the entirety of its Predator output between October and December 2015 - every unit in the channel so far, basically. The problem has been traced to the O-ring assembly between the copper cold plate and bracket on the water block - doubly embarrassing for the company, which was founded specifically to build high-quality custom water blocks. EK claims that it is currently seeing reports of leakage from one in 10 units sold through.
'We are warning all customers of EK XLC-Predator units to discontinue use of [the] cooling device and contact EKWB for replacement unit or refund,
' the company explained in its statement
on the recall. 'EKWB is taking full responsibility for this issue and will be: Replacing or refunding all returned units to the customers; Refunding the customer any computer component damage created by a leakage. EKWB has redesigned and released a new version of EK-XLC Predator (Revision 1.1) on the 4th of January 2016 that prevents any leakage under normal working modes. All customers with Revision 1.0 units will be offered a replacement R1.1 unit or a full refund.
Anyone with an EK Predator cooling system is advised to uninstall it and contact the company at their earliest convenience.