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PS, I Love You (Paperback)Cecelia Ahern (author)
- 10+ in stock
Some people wait their whole lives to find their soul mates. But not Holly and Gerry. Childhood sweethearts, they could finish each other's sentences. No one could ever imagine them without each other.
When Gerry dies, Holly is devastated. But Gerry has left her a bundle of notes, one for each month of her year, each signed 'PS, I Love You'.
As the notes are opened, the man who knows Holly better than anyone teaches her that life goes on. With some help from friends and family, Holly laughs, cries and finds that life is for living - but it helps if there's someone watching over you.
Publisher: HarperCollins Publishers
Number of pages: 512
Weight: 360 g
Dimensions: 198 x 129 x 32 mm
'This exceptional novel about bereavement, friendship and lost love is both heartbreaking and uplifting' Express
'A sensational debut novel that proves true love never dies' Cosmopolitan
'Heartbreak, intrigue and love letters from beyond the grave - Ahern has a sure and sympathetic hand'
'A bittersweet storyline guaranteed to tug on your heartstrings'
'A moving, beautiful novel' Sunday Telegraph
Acclaim for Cecelia Ahern:
'Bursting with narrative verve and ear for language...a writer hitting their prime' Waterstones.com
'Cleverly constructed, full of flavour and moving' Daily Mail
'Beautiful and unexpected ... both thought-provoking and life-affirming' Sunday Express
'Intricate and emotional ... really completely lovely' Grazia
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Enjoyed reading this book. Interestingly the story varied massively from the film so you do not read it knowing what is going to happen. I didnt enjoy it as much as i had hoped,though i think that has more to do with... More
“PS, I Love You”
This is an amazing book, it is definetly one of my two favourites,( the other being Breaking Dawn by Stephenie Meyer). You can really get into the story and half the time you won't want to put it down. I would... More
“PS, I Love You”
Read this book it is fantastic, but do not watch the film, its that bad, an insult to the book!
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The 2013 Vanguard Endurance Training and Education Camp is scheduled from June 21st June 23rd.
The team at Vanguard Endurance is nationally recognized for both the training excellence as well as the education of coaches from beginner to elite. Because of this we wanted to offer a unique camp that caters to athletes as well as coaches through a mix of training sessions, educational presentations, and hands on one to one support of both athletes and coaches in order for you to realize your full potential.
The camp will commence on Friday evening the 21st of June
The Price of the Camp is $295 per person, or $450 per couple if signed up before May 21st. Anyone signing up after this point will pay an additional 10%
We challenge you to find a better camp for less as our presenters and coaches are world class and the knowledge and experience you will get from this camp will be second to none.
Tentative Program Outline (Subject to change):
Friday Afternoon and Evening:
Meet and Greet: Fill out sanctioning forms, meet the coaches and athletes, and outline what your personal goals are for the camp and what you would like to get out of it.
Presentation: Presentation on understanding how to train smarter and get better results with less effort though the use of training plan design, field based testing and understanding your personal physiology. (Justin Trolle)
Q&A: At the end of the evening coaches and athletes will have the opportunity to ask questions of the Vanguard Endurance Elite coaches on any topic that is of interest and get our personal point of view of any aspect of the sport. We can also discuss your individual needs and goals for the camp.
Running Analysis and Run Technique Focus: During this session we will teach you the drills and techniques for making your running better so that once you go home from the camp you can continue to improve. Well analyze your stride and gait, and offer suggestions on how to improve your running form. Youll also have the opportunity to have your run analyzed by video analysis (optional please speak with Vanguard coaches for more information)
Long Cycle Session: Depending on your ability levels we will be doing a long ride. Depending on what your individual training requires these will range between 20miles and 50miles. During these rides we will look at how to position yourself in bunches safely as well as well as other technical and tactical skills to improve performance.
Off The Bike Run: An off the bike run (optional) will follow the bike session. Best practices of brick sessions frequency and types will be discussed.
Lunch and Presentation: During lunch, well discuss Swimming mechanics for triathletes: Well cover the mechanics that offer the best mechanics and efficiency for open water swimming and how these mechanics differ from pool-based swimming. Drills, training sets, and best practices for building your swim plans will be discussed. (Dave Burgess)
Bike / Run transition training: Races can be won or lost in transition so it is critical you know how to get them right. During this session we will look at how to make your transitions quick and clean while lowering the risk of crashes or injuries doing them.
Swimming Session & Video Analysis: During this session we will focus on recording your swimming for later analysis as well introducing you to speed and endurance sets and also focusing on Triathlon specific race skill development (turns, sighting, close quarters swimming etc.) Video analysis and drill suggestions will be provided to you shortly after the camp.
Presentation: Yet to be determined.
Group Dinner: Communication and fun is key to the enjoyment of the sport of triathlon so what better way to have fun and enjoy yourself than with dinner and a few drinks. Not a mandatory dinner. (not included in price of camp). Sunday Morning:
Swimming Session Review and Drill development: We will expand upon speed, and endurance sets during this swim session. Well also provide examples of what typical workouts and swim sets look like, and go through varying sets and drills.
Presentation: Field based Strength and Conditioning: Strength and conditioning is critical to injury prevention and reaching your full potential as a Triathlete. In this session we will look at things you can do from home in order to develop the conditioning you need to develop as a Triathlete Bike or Run session: Depending on the athlete, a run or ride session is planned for the late morning. Distance and intensity to be determined by need. Vanguard coaches will be available to answer any questions, and assist in any way during this session. Further in-training discussions on cadence, tactics, positioning, and best practices will be administered.
Final Presentation and Wrap-up: Camp review, Q&A, and good-byes.

domain: hobby


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Alongside smiley faces and hasbrowns, potato waffles are pretty up there when it comes to frozen, potato-based snacks.
But Birds Eye have got 2020 off to the best start be revealing the correct way to cook potato waffles and you won't believe how much time it will save.
For a long time, customers have wanted to know whether or not it was safe to cook the potato favourite in the toaster.
And 103 hours and 3,000 waffles later to test whether they can approve of the time-saving method the answer is in.
Yes, you CAN safely cook your potato waffles in the toaster, the Daily Star reports , and now we know what we're having for lunch at work for the foreseeable.
To reassure customers further, Birds Eye have said that they will add "toasting" as a new cooking method to the packaging of its Original Potato Waffles.
So instead of waiting at least 20 minutes for them to cook in the oven, next time you can wait just a matter of minutes. Result.
Birds Eye spent 20 days conducting its research on the cooking-method by using a variety of different toasters and settings to ensure that they could official say that it is safe and will still deliver on the taste and texture you get by cooking them in the oven.
Going to give it a go?
To be able to happily tuck in to the perfect potato waffle by using your toaster, all you need to do is set your toaster to a medium/high setting and pop them in.
Once you get the first "pop" of the toaster, you should put them in again for a second time.
And voila. You should have a golden yellow, fluffy potato treat in around five minutes.
The test came about after Birds Eye questioned fans on Twitter and Instagram which revealed that 65.2% of respondents didn't know the popular dish could be toasted this way.
Steve Challouma, Marketing Director at Birds Eye, said: "We know there has been a lot of confusion and debate on this way of cooking our Original Potato Waffles so we decided to put it to the test.
"After days of rigorous 'toasting', we're happy to confirm it is safe to cook our waffles this way and it doesn't compromise on taste either – you can still expect the same delicious taste that is crispy on the outside and fluffy in the middle!"
Well, this is a game-changer.

domain: food


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A sampling from our Member Sites(s) Use the link above to review/visit
Toho Light Opera Scrapbook
Sketches from the first Toho All-Monster Production of Gilbert and Sullivan's H.M.S. Pinafore, with comments by the leading actors and actresses.
Gilbert and Sullivan Shop Online.
The Gilbert and Sullivan Shop Online have searched the web to find 100s of G&S resources, then put links to them all in their website. They have found musical scores, libretti, CDs, audio cassettes, videos, DVDs, books, Children's versions, performance aids, memorabilia, midi files, gifts and much more.
By grouping them by format and opera, they hope to sav
Savoy Opera Reviews
Collection of transcriptions of reviews and articles relating to Gilbert & Sullivan from early newspapers & periodicals. Particularly useful for students, authors of programme notes, etc.
Gilbert and Sullivan mp3
Download free mp3 Gilbert and Sullivan songs in a light modern style. Songs arranged and sung by Bob Eagle. All music in public domain.
Leicester Operatic Players
The website of the Leicester Operatic Players, an international award-winning amateur group producing annual operetta or musical shows (G&S in alternate years) to the highest standards.
Click here to preview and visit the 8 member sites in
Gilbert and Sullivan.

domain: artistic


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Spinal Decompression Therapy
Stop Pain With Spinal Decompression Therapy
If you are suffering from sciatica, radiating pain, numbness in hands and fingers, back pain, neck pain or headaches/migraines – decompression therapy from Dr. Kroll’s Health Solutions & Disc Center might be the answer you are looking for.
This therapy is an FDA-cleared safe procedure used to treat patients with disc herniations, disc bulges, and degenerative discs. It is also for those who have experienced back and neck injuries. The decompression treatment is a non-surgical therapy that creates a vacuum at the problem disc. The DRX 9000 machine gently pulls at a negative G Force to mimic antigravity. This gentle force pulls the disc back into the proper position, removing the pressure off the nerve. The success rate is from 70% – 92%. Call us for an appointment today.
Thorough Treatment Process
During the consultation Dr. Brian A. Kroll, D.C. will review your diagnostic imaging such as MRIs, X-rays and CT scans to identify any disc herniation or other spinal abnormalities. The determined diagnosis may be treated by the DRX 9000 machine, followed by a cold laser treatment (this helps to seal up the disc). Spinal decompression will be recommended, if you are a candidate.
Depending on the severity of your condition, treatments range from 2-3 sessions per week for approximately six to fourteen weeks.
Benefits of Spinal Decompression
- Quicker recovery time from injury and a faster work return
- Less chance for chronic degeneration and immobilization problems
- Improved flexibility within muscles while restoring mobility in the spinal area
- Less tension on other parts of the body due to gravity pulling down on discs that are no longer being compressed by spinal bones because they have decompressed from excessive pressure over time
- Added flexibility reduces muscle and joint pain in other parts of the body
- Improved circulation to spinal nerve roots, discs, muscles, ligaments and vertebrae leads to less inflammation and more range of motion
- Helps with pressure on nerves because as they decompress, it takes some weight off them, which was putting pressure on them before
- Spinal decompression therapy is shown to reverse, or at least alleviate the degeneration symptoms within weeks or months
Effective Solution for Many Ailments
- Chronic back or neck pain
- Radiating pain into the hands and fingers
- Bulge discs
- Herniated discs
- Stenosis of the vertebral canal

domain: medical


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By Katherine Handcock, A Mighty Girl Senior Research Intern
The love between fathers and daughters can be the inspiration for some incredible music. As part of our celebration of the wonderful Dads out there raising Mighty Girls, we wanted to share our top five father-daughter songs. Whether the song is in the father’s voice, wondering at this amazing girl in his life, or in the daughter’s voice, reflecting on the strength her father gives her, these songs are sure to be a hit this Father’s Day!
We will describe each song here, but for more details, including information for parents about content in the lyrics or video, and to preview songs via embedded YouTube videos, please click on the links to view the full entries. Most of these songs, like the majority of the titles featured in A Mighty Girl’s music section is available through either iTunes or Amazon.com’s MP3 download service (or both), via the links on each song's page. By using the links on A Mighty Girl, you also help to support the site at no added cost to you, and can have your Father’s Day playlist set up in no time!
For Mighty Girl books that celebrate the father-daughter relationship, please also check out our first Father’s Day blog, A Father’s Love: A Mighty Girl Celebrates Father’s Day. Continue Reading


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I'm a 30 year old kiwi, working in advertising in Melbourne.
I have an eclectic style. I love mixing vintage items with high street and designer pieces. I'm draw to things that are interesting looking but most of all are comfortable!
Oh and i'm size 10.
If you fancy having a peek inside my wardrobe, check out the video here:

domain: design


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Worthplaying has hands-on impressions of Tribes: Vengeance and coverage of the press event that took place in San Francisco last night:
Movement. Focus testing, feedback from old players, especially the new generation (who are used to playing BF1942, etc.), has shown that the controls needed to be improved, so the developments team has worked on better air and jetpack control. Accelerating in order to pick up speed was proven too difficult and has been addressed and the "skiing," sliding down ramps or other downward angle contraptions, has remained intact.
Large Maps. In these days of quick round-based action games, a lot of the feedback pointed out that Tribes was sometimes too slow. New players who joined a multiplayer game often complained that they did not find the action fast enough, which had a negative impact. Often, people did not bother to learn the hows and wheres, but instead decided to leave the game and forget about it. This time around, IG will keep the large maps but also include smaller maps, creating specific content for a specific number of players. The game will feature maps suitable for anywhere from two to 32 players, with specific game modes that will allow the players to enjoy the maps and find instant action.


JOHANNESBURG (Reuters) – South Africa’s Competition Tribunal granted conditional approval for the proposed merger of about $100 billion by brewer Anheuser-Busch Inbev and SABMiller, the anti-trust authority said on Thursday.
The Tribunal, which gives the final word on mergers in Africa’s most industrialised country, said in a statement that the conditions are designed to address both public interest and competition concerns arising from the merger.
After the green-light, AB InBev’s CEO Carlos Brito said in a statement that the brewer was on track to close the merger in the second half of 2016, adding that South Africa was “a market that would play a critical role in the combined company.”
The takeover will give the Belgium-based maker of Budweiser, Corona and Stella Artois a third of the global beer market, selling twice as much as its nearest rival Heineken.
AB InBev shares were suspended before the announcement.
As part of the conditions, the Tribunal ruled that no South African employee be laid off for five years after the merger.
Other conditions to the tie-up include a requirement the merged entity sell off SAB’s stake in liquor maker Distell as well as investing 1 billion rand ($68 million) in South African agriculture and enterprise development.
The two key approvals required are by the United States and China, although the proposed disposals there are expected to lead to clearance. Australia and Europe have already given their blessing to the deal.
($1 = 14.7585 rand)
(Editing by James Macharia)
© Thomson Reuters 2016 All rights reserved


Astrocolor has been a mainstay of the Victoria music scene since their first release in 2015.
They’ve now released six full-length albums and won various awards for their musical prowess in the Canadian music scene.
They were named instrumental artist of the year in 2022 at the Western Canadian Music Awards for their signature sound, which blends psychedelia, jazz and electronica.
They’ve been featured on CBC’s Drive and Afterdark, they’ve been one of the Zone @ 91-3’s favourite Victoria bands since their inception and they have played all the largest stages on the west coast.
On Friday, March 31st, Astrocolor released their sixth album into the world. The new record is called Moonlighting – AstroJazz Vol. 1 and is unmistakably an Astrocolor, cosmic rendition of a genre that has stood the test of time.
Moonlighting – AstroJazz Vol. 1 was produced and mixed by Steve Christensen, a Grammy award-winning producer best known for his iconic collaborations with Khruangbin.
Khruangbin has helped redefine the way generations of music-lovers listen to instrumental music thanks to Christensen’s vision which has now been applied to Astrocolor’s newest sound.
The new album is unequivocally spacey and cosmic. Its tracks build throughout the record to bring about a concise and well executed overall sound which will no doubt have listeners’ feet tapping and heads bopping along to the beat.
It is jazzy in an approachable way. It isn’t pretentious, its well executed and is rife with smooth saxophone, piano and guitar parts blending and letting each other have their moments while the drums and bass ground the sound and give it a hypnotic, medatative feeling.
Close your eyes with headphones on and you’ll see yourself traversing a meteor belt in deep space with strange and foreign planets passing you by.
The record was engineered at Burning Rainbow Studios right here in Victoria.
Astrocolor is hosting not one but two intimate album release shows in the evening of March 31st at Hermann’s Jazz Club.
As of this publication, there are little to no tickets left for the live release show, but Moonlighting – AstroJazz Vol. 1 is now streaming on all major platforms. Vinyl and CD copies of the record can be found on Astrocolor’s website.
Here is Moonlighting – AstroJazz Vol. 1! Let us know what you think in the comments below.
Astrocolor at Hermann’s Jazz Club
- Where: Hermann’s Jazz Club, 753 View Street 2 floor
- When: Friday, March 31st, shows at 6 p.m. and 10 p.m. (may be sold out)


Deanna R. Fischer, 39, of Hershey, was sentenced Wednesday to 364 days in the Lincoln County Detention Center. Investigators said Fischer was complicit and took photographs of sexual assaults perpetrated by her husband Daniel in their home. She was also charged for other alleged crimes that occurred more than eight years ago.
Fischer was sentenced twice, once for sexual assault of a child and once for child abuse, but the sentences will run concurrently -- at the same time.
Fischer will get credit for the 23 days she has served in jail and she must register as a sex offender for 15 years.
Fischer was convicted in Lincoln County Court March 12. The charges were originally felonies but were reduced to misdemeanors in a plea deal with the Lincoln County Attorney’s Office.
In court Wednesday, Chief Deputy Lincoln County Attorney Tanya Roberts-Connick noted that the pre-sentence investigation did not recommend probation.
Defense attorney Michael Nozicka said it is a sad situation.
“Her husband killed himself over this and Deanna feels she has been left holding the bag.” Nozicka said. “The state couldn’t prosecute Daniel so they turned to the next best thing. It is a matter of a difference of opinion that a period of probation would be suitable for rehabilitation and that would certainly cost the state less money.”
Troshynski asked on Deanna’s behalf that she be sentenced to the county jail instead of the Hastings Correctional Center for women. He also asked for a few days for Deanna to get her affairs in order.
Lincoln County Judge Michael Piccolo agreed that it has been a difficult case.
“Obviously I don’t take sentencing in cases like this lightly,” Piccolo told Fischer. “I do, though, have to take into consideration a recurring theme in the pre-sentence investigation that shows no accountability in all this on your part.”
Based on the lack of accountability and the kind of victims involved, Piccolo said probation is not appropriate, and he ordered Fischer to be taken to the detention center directly from the court room, with no delay.
Daniel Fischer was charged with nine counts of sexual assault of a child. After the charges, while out on bail, he took his own life.


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The Strathmore and District Curling Club is looking to restart after having to shut down in March due to COVID-19.
The club held its annual general meeting on Sept. 23 and is looking to restart league play in the middle of October, explained Ken Shackleton, club president. A financial report and new distancing guidelines were discussed during the meeting and new board members were elected.
There’s strong interest in the club members to return to play – a survey conducted by the club indicated that 90 per cent of respondents are interested in curling this year, he said.
Prior to the pandemic, the club approached town council with a proposal for it to host one of the Curling Alberta championship tournaments in Strathmore in February or March 2020. However, for now, these plans have been put on ice, said Shackleton.
“Basically, those plans are on hold until we can get the club reopened and see how things go this season, in light of COVID(-19),” he said. “Then, we’ll take a look at it again later on in the season if we can.”
The club must decide by the end of January as to whether to apply to host the championship. “Once the club’s open (and) we’ve got things rolling again and any new board members are on board, we’ll take a look at it and decide, probably before Christmas.”
Sean Feagan, Local Journalism Initiative Reporter, Strathmore Times

domain: news


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Planned Economy v1.0: It is illegal for anyone to operate a business without approval from a government ministry. Government experts decide which companies can operate, from which locations, and engaging in which businesses.
Planned Economy v2.0: Set up tax rates that are, by global standards, punishingly high. It is therefore impractical to do business if a company must pay the headline rates. Government experts decide that certain companies, in certain locations, and engaging in certain activities, can operate with tax rates that are closer to global norms.
On Trade, France makes excellent wine, but so does the U.S. The problem is that France makes it very hard for the U.S. to sell its wines into France, and charges big Tariffs, whereas the U.S. makes it easy for French wines, and charges very small Tariffs. Not fair, must change!— Donald J. Trump (@realDonaldTrump) November 13, 2018
Некоторые вещи совсем нельзя понять. Допустим, война с Китаем необходима, чтобы зажечь и воодушевить американский пролетариат. А вот это зачем? Привлечь на свою сторону владельцев калифорнийских и нью-йоркских виноградников? Там какие-то большие политические силы?

domain: law


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Poems, Short Stories, Novels and More
Still under construction, but eventually, I hope to catalog most of the poems I've ever written, dating back to high school. I'm sure you'll find some of these interesting, touching, even challenging; but keep in mind that my standard, especially for the earliest of the material, has been "that which is forgivable."
Links to my first full-length novel, Leviathan's Scales, my novelette Faith of a Father, which is the centerpiece for a book of short stories, and a project to which I was a contributor, Telling The Truth And Nothing But, a compilation of essays on plagiarism.
Excerpts, and in some cases the full story, of various short works, including "The Milkhouse", "The Unforgiving Hand", "The Famous Gunfighter" and more.
Links to individual versions of my Daily Herald newspaper column, "Letter to Readers"
I like to recite poetry and interpret the lyrics to popular music - Shakespeare, Browning, Stairway to Heaven, MacArthur Park, Desperado and much more. Right now, I've just started with audio, but I'll add video when I learn more about the technology and the process. It's different! You might enjoy it.


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Over the years, with the increasing number of streaming platforms, there’s been a surge in TV series created for general audiences. Growing up, I was only able to watch whatever cable TV offered to me. Most of the shows consisted of highly fabricated and unrealistic storylines. They made life as a teenager seem utopian. Luca Guadagnino’s new series “We Are Who We Are” ensures that teens today grow up with realistic notions of what adolescence is actually like in modern times. While it took me a while to fully understand the basics of the show, all of a sudden it hit me like a bus. Fraser Wilson (Jack Dylan Grazer, “It Chapter II”) is the new and out-of-place 14-year-old on a U.S. army base in the beautiful town of Chioggia, Italy where he meets Caitlin (Jordan Kristine Seamón, “Miu Miu: Icons), who struggles with her gender identity. After watching the third episode, I came to the conclusion that both Fraser and Caitlin are essentially platonic soulmates who were once lost but just so happened to find each other at the perfect time.
After catching Fraser taking pictures of her in class and getting followed by him to a bar the night she dresses up in boy’s clothing, Caitlin’s a bit fed up with his antics. It frustrated me to see her not recognize the desperate attempts that Fraser was making in order to find his place. It’s clear that there are some underlying issues Fraser has with himself and his two lesbian mothers, who struggle to adequately get ahold of his outbursts. He deals with his frustration, anger and fear of abandonment by creating a persona. Meanwhile, Caitlin displays discomfort with her mother but adores her father. When Fraser and Caitlin meet, their connection blossoms into a beautiful yet raw platonic friendship that explores love and individualism. Since both come from households with parents who are unable to provide the care that they are looking for, Caitlin and Fraser find that care in each other.
Many TV series don’t focus on developing relationships like these because of their focus on the storyline. Television can be so influential, and it’s crucial that teens can place themselves in the storylines that are presented to them. In today’s world, where it is widely accepted to explore one’s gender and have the right to determine how to identify, it’s comforting to see Caitlin’s character arc because these are the issues that actual teenagers face in real life. However, Fraser also uses Caitlin as a blueprint to help him understand the importance of close, interpersonal connections. It’s important to introduce these inner conflicts. There’s no sugarcoating it. They both learn and settle their issues by leaning on each other. One can learn how to face these types of situations just from watching the series.
And because nuanced stories about friendship are underrated in modern-day TV, as I continued watching the show, I wondered why most teen TV shows are so focused on sexual relationships instead of platonic friendships. Friendship is the first stage of love. Friendship is love. There’s nothing wrong with having two characters meet and create a friendship that doesn’t end with the two of them being in a sexual or romantic relationship. Why? Because teenagers aren’t monolithic. What about the teens who only seek friendship? Or the teens who aren’t aware of what true friendship is? Or how to maneuver through a friendship while also struggling with self-discovery?
Everyone needs someone to help them through the hardships and confusions that life throws at our feet. Caitlin made Fraser feel welcome and Fraser allowed Caitlin to feel comfortable with who she was becoming. This is pure friendship that every teenager must witness. And as television continues to advance in the world of streaming, we should make note of how certain TV shows are capable of allowing those to maneuver in a world that is meant to be seen in a more realistic light. Television is for entertainment purposes, of course, but if the entertainment industry continues to exploit the teenage demographic by providing impractical enactments, there will be a lot of teens with high expectations.
Daily Arts Contributor Jessica Curney can be reached at firstname.lastname@example.org.

domain: sociology


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More than 80 percent of children in economically disadvantaged families are “parentified” children — meaning they have to share the role of parents in a family — a survey by the Taiwan Fund for Children and Families (TFCF) and the Children’s Welfare League Foundation showed yesterday.
Eleven-year-old Ling (小羚) lives with her grandmother and three siblings in Greater Tainan’s Jiali District (佳里) after her parents divorced and, despite her young age, she takes on the role of a parent in their absence.
“I wake up at about five every morning, and look after my little brothers and sister when my grandma goes out to wholesale market to get vegetables,” she told a press conference in Taipei yesterday. “On weekends or holidays, I go with my grandma to local markets to sell vegetables.”
When Ling returns from school, she does the chores, cooks, bathes her brothers and sister, and helps them with their homework.
Ling’s case is not an isolated one.
“Kids who have to take on the job of being a parent are called ‘parentified children,’ and it’s surprising for us to find in a recent survey that as many as 80 percent of children in economically disadvantaged families have to act like parents at home,” said Weng Hui-yuan (翁慧圓), director of TFCF’s department of social work.
“Most parentified children don’t feel that they are forced to do the job and most do so willingly, but many respondents told us in the survey that they feel tired, psychologically pressured and hopeless,” Weng said.
The two organizations conducted the survey at the end of last month and they collected 1,071 valid samples from third and fourth graders in economically disadvantaged families across the country.
The survey shows that more than 80 percent of the children not only need to help out with household chores, but that they also take care of younger siblings in the family, while 16.7 percent of the respondents even have to earn money for their families.
When asked about their willingness, more than 70 percent of respondents said they believe they are doing what they are supposed to, while 25 percent said they are doing the job because no one else can help out.
The organizations urged the public to lend a helping hand to parentified children.
“Without the appropriate help, these kids may become autistic, have problems getting along with other people and suffer from low self-esteem, since they feel ‘different’ to their peers and they don’t have anything in common with them,” TFCF executive director Miguel Wang (王明仁) said. “As able adults, we should try to help.”
CONFUSION: NTHU was told by the Hsinchu Public Health Bureau to not delay disease prevention efforts, but the university’s case had not yet been announced by the CECC The Central Epidemic Command Center (CECC) yesterday said that it would set guidelines for other agencies about disclosing information concerning confirmed cases, after some schools expressed confusion regarding interagency communication. Academia Sinica, National Chengchi University and National Tsing Hua University (NTHU) have issued announcements to clarify their quarantine measures for confirmed cases. Asked if the center provides guidelines about information disclosure, Centers for Disease Control Deputy Director-General Chuang Jen-hsiang (莊人祥), the CECC’s spokesman, on Friday advised institutions to check with the CECC before revealing any information beyond what it has announced, citing its smooth collaboration with Academia Sinica as a good example. After
People who throw away their masks in public areas can be fined up to NT$6,000, the Ministry of Health and Welfare said. Masks fall under the category of general waste and should be disposed of in regular garbage bins, the ministry said. However, those who discard their masks on the street can be fined NT$1,200 to NT$6,000 under the Waste Disposal Act (廢棄物清理法), it said. Local governments have reported an increase in the number of discarded masks since the COVID-19 outbreak began, as the use of masks has skyrocketed. In Pingtung County a group of volunteers within an hour picked
The High Court on Thursday rejected an appeal by former Taiwan Federation of Financial Unions deputy director Lai Wan-chih (賴萬枝), upholding a sexual assault conviction against him. In 2017 the Taoyuan District Court found Lai guilty of sexually assaulting a secretary, sentencing him to three years and two months in prison in the first ruling, which he appealed. Court documents showed that Lai was part of a federation-organized weekend trip to Nantou County in June 2014. After dinner and KTV, Lai and others in the group went to the secretary’s room and he remained until they were the only two left, the documents
The Ministry of Education has allocated NT$400 million (US$13.2 million) to help universities affected by the COVID-19 pandemic. The funds are to be used to support schools that have had to introduce “flexible tuition” and “flexible learning” options for overseas students who are unable to return to their schools in Taiwan, and to help schools purchase disease-prevention supplies, such as masks and thermometers, the ministry said in a statement. Public and private universities have until April 15 to apply for the program, it added. About NT$100 million of the funds would come from the government’s special COVID-19 budget, the ministry said. The Legislative Yuan


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Libyan National Army cut off water to Tripoli and other cities.
On Sunday 30th June, forces loyal to the warlord Field Marshal Khalifa Haftar had stormed a pumping station run by the Great Man-Made River south of Tripoli, forcing employees to shut down water pipes connected to underground wells.
The UN-recognized Government of National Accord (GNA) accused the forces loyal to the LNA of seeking to “lock the water from the capital to lower the morale of its inhabitants” as well as to press authorities to release a prisoner.
“Cutting off the water supply from the capital Tripoli and its environs by groups following Khalifa Haftar is another act of human rights violations and war crimes,”Government of National Accord
Although, the water supply to Tripoli, Libya’s capital city and home to 2.5 million people was restored two days after they were cut off by gunmen, at the very least, 2 million residents would have been severely impacted if the water had remained shut off.
Weaponising water supply a war crime
For that reason, the United Nations spokesman Stephane Dujarric said humanitarian officials were deeply concerned after the attack on Sunday, strongly condemned it saying it could amount to a war crime. The United Nations has warned all sides that water should not become a weapon of war, but the water system is already badly damaged.
For Libya, water is becoming a far bigger concern for its people. The embattled North African country is currently the fifth on the list of most water-scarce countries on Earth.
Since the eight years of near-anarchy since Muammar Gaddafi was ousted, water interruptions have been a common occurrence. Typically, the LNA, in particular, has been accused of using the water pipeline supply system to push through its demands, thereby endangering Libya’s population.
In the 1980s, during the regime of Muammar Gaddafi, a vast pipeline system known as the “Great Man-Made River” was constructed since Libya is mainly made up of arid desert. These pipelines supply more than 70 per cent of Libya’s population with fresh water. However, since the fall of Gaddafi, the water supply system has been targetted and damaged multiple times.
Oftentimes, Libyan citizens also dismantle wellheads to sell the copper further compromising the fragile water supply system. The western parts of the country, in particular, are running out of drinkable water as a result of the damage caused to both the power grid and water control system in LNA’s Sunday offensive.
Looting and neglect have made the situation fragile and armed groups have exploited the unrest, about 101 of 149 conduits of the water supply system have already been destroyed.
As far back as 2011, the UN Secretary-General, Ban Ki-moon, made a plea to world leaders to “come together as one” to help Libya deal with humanitarian concerns. He said there were widespread shortages of fuel, food and medical supplies, and that problems with the water supply in Tripoli were putting the lives of millions of people at risk.
Furthermore, even though NATO also target water supplies during its 2011 intervention, armed groups targeting of civilian infrastructure, especially of water supplies, is a war crime under the Geneva Conventions, writes Nafeez Ahmed.
Impact on Libya’s society
According to a UNICEF report presented by Mostafa Omar, a spokesman for the organisation in Libya estimates that, in future, some four million people might be deprived of access to safe drinking water if no solution to the conflict is found. This could result in outbreaks of hepatitis A, cholera and other diarrhoeal illnesses
Even worse is that water is not only scarce, but it’s also contaminated in many areas. Badr al-Din al-Najjar, the head of Libya’s National Center for Disease Control said that bacteria or a high content of salt make it unfit for consumption. ‘Often, in fact, it’s no longer drinkable water.’ Also, local bottled water in a country has become contaminated as a result.
The UN estimates that the battle for Tripoli that began last month has killed at least 510 people, wounded nearly 2,500, forced 75,000 out of their homes, and also forcing schools to close as well as causing power-cuts.


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Home to a range of museums and art galleries, the Square also allows visitors to enjoy live music, live theater, and other outdoor and indoor events that are held there throughout the year.3220 Botanic Garden Blvd., Fort Worth, TX, Phone: 817-392-5510 Fun day trip ideas: Weekend Getaways in California, Best East Coast beaches, SC, TX, NC quick trip, Romantic weekend getaways Listed on the National Register of Historic Places, the Fort Worth Stockyards is a historic district in the heart of Fort Worth as well as a testament to the livestock industry in Texas.Once the last major stop for rest and supplies for the cattle drovers heading the cattle up the Chisholm Trail to the railheads, Fort Worth served as a major center for the livestock industry with the Fort Worth Stockyards at its center. 23rd Street, Fort Worth, TX, Phone: 817-626-7921 Things to do near me: Weekend Getaways from Seattle, NC day trips, FL, From Phoenix, WV, IN, Near Atlanta, AL The Kimbell Art Museum is a comprehensive art museum that houses a small, but superb collection of 350 works of art, as well as an extensive research library and various educational programs. Kahn, the building is recognized as a significant work of architecture, particularly for the natural, silvery light that flows across the vaulted gallery ceilings.Other habitats and exhibits include Raptor Canyon, World of Primates, Meerkat Mounds, Parrot Paradise, the Great Barrier Reef, and the Museum of Living Art (MOLA).The zoo features state-of-the-art facilities, as well as pleasant walkways, shade structures, walkways, picnic areas, and some food outlets.
Some of these beautifully manicured gardens include a “Back Yard Vegetable Garden,” a beautiful vegetable garden that hosts a variety of community-based educational programs, a 10,000-square-foot conservatory which houses tropical species such as orchids and bromeliads, and a unique Fragrance Garden that the visually-impaired can enjoy.


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WILKES-BARRE TWP. — Patrick Abdalla was straightening up around Barnes & Noble’s magazine section after closing time Wednesday night, but his mind was already elsewhere.
Intense wind and rain had begun to pick up outside the bookstore in the Arena Hub Plaza amid warnings about severe thunderstorms and possibly tornadoes. Cellphone reception had become spotty.
“It was so windy and crazy,” Abdalla recalled Thursday.
He was able to get through, briefly: Things were OK at home.
Abdalla nearly wasn’t.
“Within five minutes, I saw the side window blow in,” said the Wilkes-Barre resident, who works part-time at the bookstore while attending graduate school. “It was like a movie explosion.”
When he turned around, the store’s back wall was gone and rain poured in.
Abdalla was brushed by some flying glass, but escaped essentially unharmed.
His workplace had sustained serious damage, however. Barnes & Noble was one of at least 23 businesses in and around Arena Hub Plaza that were damaged or destroyed when the tornado, with winds gusting up to an estimated 130 mph, devastated the township’s shopping and commercial heart along Mundy Street.
The storm that swept through the area late Wednesday left destruction in its wake, but it also left businesses in the dark about what happened to their workplaces, and what happens next.
Social media posts from Barnes & Noble’s local accounts suggested the firm remains committed to its Arena Hub location.
“We will work hard to assess the damage and begin repairs as soon as possible,” a message sent out Thursday said. “We love our Wilkes-Barre community and look forward to serving you again soon!”
Robert Tamburro, trustee and general partner of TFP Limited — owners of the Arena Hub Plaza, Mundy Street Square, 275-277 Mundy St., and 100 Commerce Boulevard — said many of his tenant businesses were severely damaged by the tornado.
“God was with us,” Tamburro said. “No doubt about it. That nobody was killed and nobody seriously hurt is a miracle. To have that powerful of a storm come through and touch that many properties, like I said, it’s a miracle.”
Police and hospital officials have said about six people suffered relatively minor injuries Thursday night.
Attempts to reach corporate officials from three damaged stores — Barnes & Noble, Dick’s Sporting Goods and Panera Bread — were unsuccessful Thursday afternoon.
Anxious to see
Thursday morning’s bright summer light brought only more anxiety for many managers and employees, as barricades kept them away from the plazas due to safety concerns, including fumes from a large propane tank at the nearly obliterated U-Haul store on Mundy Street.
Chuck Sullick, general manager of Best Buy, couldn’t help but look from behind the caution tape and think about the fate of his store Thursday morning.
“I wasn’t here last night, so I didn’t get to see how bad it looked,” Sullick said. “My main concern was that my employees got home safe.”
Sullick said he has been in contact with the Best Buy’s corporate offices.
“They said to just them know if myself or my employees need anything and just to keep them updated.”
“Wilkes-Barre is strong,” Sullick said. “We just need to pull back together as a community.”
The general theme for every manager Thursday was to just tell their employees to stay home, because they themselves don’t know their store’s fate.
“I was in shock,” Michael’s store manager Hubert Herrera said. “I never thought this could happen in this area but the most important thing was making sure my employees were safe.”
Michael’s is located right next to Dick’s Sporting Goods, which was heavily damaged by the storm. Part of its sign was discovered miles away in Bear Creek, officials said.
“I don’t know if the damage from Dick’s is going to be a problem for us,” Herrera said. “But judging from a distance, I hope we can operate soon.”
At Barnes & Noble, Abdalla was one of only a handful of employees still left in the building when the storm hit.
A devotee of history and baseball, working in the bookstore has been a welcome gig for Abdalla, who praised his coworkers and managers as “amazingly beautiful, vibrant, funny people.”
“When the store opens back up, I’ll be back to work there,” he wrote in a social media post about the storm. “I look forward to it.”
Brigid Edmunds-Lawrence, Bill O’Boyle and Dan Stokes contributed to this report.
For more on Wednesday’s tornado, click here.


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Mitochondrial outer membrane permeabilization (MOMP) is a key checkpoint in apoptosis that activates the caspase cascade and irreversibly causes the majority of cells to die. The proteins of the Bcl-2 family are master regulators of apoptosis that form a complex interaction network within the mitochondrial membrane that determines the induction of MOMP. This culminates in the activation of the effector members Bax and Bak, which permeabilize the mitochondrial outer membrane to mediate MOMP. Although the key role of Bax and Bak has been established, many questions remain unresolved regarding molecular mechanisms that control the apoptotic pore. In this review, we discuss the recent progress in our understanding of the regulation of Bax/Bak activity within the mitochondrial membrane.
Keywords: Apoptosis; BCL-2 proteins; Lipids; MOMP; Membrane dynamics; Protein-protein interaction.
Copyright © 2021 Elsevier B.V. All rights reserved.


Being a traveller, I am always on the move. I love celebrating my life on the road. The journey to unknown simply fascinates me. While travelling, I love to take a nap in the lap of nature, talking to locals, sharing that one smile simply makes me high. Popping my head out of the window, I am not just amazed by everything I experience, I like to capture those moments into my lens to treasure those priceless moments. The fact is that it is not feasible every time to use your DSLR. So, I prefer Smart Phone photography a lot of time. It is easy to capture the desired moment, but at the same time incredibly easy to share it with the world. But when it comes to battery life of the smart phone, it fails to impress me.Many times, while on the move,I want to capture those rare moments and my battery gets exhausted.It not just spoils the fun of capturing moments but also contributes equally to spoiling your joyous mood. Being a Travel Blogger, I was longing for a solution for this.
And here it comes. Asus has launched this brand new phone called Zenfone Max with some power packed features which has created a revolutionary impact in the market. It was a couple of days before the launch I received this phone in a nice glass box with an embargo till 23rdMay. I must admit that Asus had successfully managed to create the curiosity. On 23rd May, Asus finally unveiled the advanced version of one of its best-selling smartphones in the country – Zenfone Max. The elegant style and 5000 mAh battery simply takes Zenfone Max to a new level all together. Let me take you through its Key Features.
The revolutionary feature of Asus Zenfone Max is undoubtedly its uncompromising battery life. The most celebrated feature,which makes this phone stand alone in the market. With 5000 mAH, Asus has certainly brought a revolution . A powerful device which not just gives you a powerful battery life but also a promise that one can keep the full charged Asus Zenfone Max for days without charging. The lithium-polymer battery, when fully charged, provides 914.4 hours of standby time or 37.5 hours of 3G talk time or 32.5 hours of Wi-Fi web browsing or 72.9 hours of music playback or 22.6 hours of video playback. The accompanying OTG cable turns the phone into a charger to power up the users’ other gadgets, making it a useful everyday accompaniment.
Look and Design
The very first thing I noticed about this phone was its look and design. Asus Zenfone Max is sleek, stylish and super smart to carry anywhere. Available in three different colours –black, orange and blue, the new Zenfone Max boasts of an extremely thin body that measures only 5.2 mm at its thinnest edge. The 3.5mm socket and Micro-USB port are at the top and bottom respectively. The notification light is at the front.The surrounding metal-like edge makes it durable while the back with a look and feel of embossed leather makes the phone look chic and fashionable for every occasion.
Enhanced and Superior Performance
The new Zenfone Max gives the users a super-responsive lag-free user experience because of the Qualcomm Snapdragon 615 Octa-Core processor with a 2GB or 3GB RAM. The use of the latest 4G LTE technology enables the users to utilize high mobile data speeds.It helps people like me who like to keep a lot of handful data while travelling. Users can enjoy multi-tasking and blazing fast performance, enabling them to live their digital lives to the fullest.
Enriching User Interface
Asus Zenfone Max is backed by Android M 6.0.1 and ASUS ZenUI, which includes advanced features to satisfy power users. The Power Saver mode helps users manage and extend the battery life even more. With five battery modes and two smart switches that users can configure to make their own battery optimization settings and help the battery last even longer. This feature is really helpful for people who are travelling most of the time.
The camera quality of Asus Zenfone Max is good. With 13 Megapixel, f/2.0-aperture rear camera with the ASUS PixelMaster2.0 technology and dual-LED flash, Asus Zenfone Max is best for natural-looking photography. It also features Laser Auto Focus technology that helps photography enthusiasts focus on an object in as fast as 0.03 seconds. The ZenFone Max’s front camera is a 5Megapixel, f/2.0-aperture camera with 85 wide-viewing anglethat helps in incorporating more information and details into the picture.Interestingly the good number of modes and manual setting stills and video is another feature for people like me who love to capture moments into the lens. The effects such as slow motion, HDR, time lapse, panorama and beautification offer great options for camera lovers. To add to it, video recording, flash toggle, and camera switching are easily accessible from the default screen.
Another striking feature of Asus Zenfone Max is its display quality. Featuring a 5.5 inch HD (1280 x 720) IPS display with full-screen lamination and ASUS TruVivid technology, Asus Zenfone Max provides superior clarity, brightness and touch responsiveness. The Bluelight Filter for Eye Care protects the users’ eyes from strain during prolonged usage.
With all these powerhouse features, Asus Zenfone Max is certainly the desirable phone with an affordable price. I have been using Asus Zenfone Max and my user experience is satisfactory. The long lasting battery life is the remarkable feature of Zenfone Max. Asus Zenfone Max comes with loads of Asus apps which are pre-installed in the device. Though that makes the phone little heavy on the user prospective as it needs constant updating along with your desired apps. Though, apps like 1Tap Boost and Power & Boost are really helpful to optimize the apps to boost the power of your phone. The TruVivid technology of Asus Zenfone Max has impressed me as it just gives you the bright, clean screen with super responsive touch screen experience. So, if I have to sum it up, Asus Zenfone Max is a stylised device with intelligent and innovative features that encompasses new age technology. Asus Zenfone Max is an absolute solution to your battery issue. This smart phone is undoubtedly my travel partner for life.
Rs.9,999 ( Zenfone Max with 2 GB RAM )
Rs. 12,999 (Zenfone Max with 3 GB RAM)
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This smart phone is undoubtedly my travel partner for life. Are you sure? Bill Gates once said “640K ought to be enough for anyone.” You know what we mean 🙂 Of course it is a good phone and we too reviewed it today.
SandeepaChetan recently posted…Zenfone Max: Gift from Asus for your travels


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"5 star...Oh wow!...Ideal for online gaming with my laptop....PROS: Mouse is made well, has grip sides and rest support for thumb Multiple customization buttons and speeds Able to setup multiple profiles, I found this useful for "game mode vs standard mode" Software makes it very easy to customize every setting on the mouse Includes weights for the mouse to set the drag to the level you like CONS: Price , I feel it is a little overprices versus competitors Software must run in background Overall I would recommend this mou"
Plow through the competition with this Logitech Lightspeed wireless gaming mouse. A 1 ms response time ensures that every movement translates almost instantly on the screen, and the ultra-precise optical sensor means that every twitch is recorded with accuracy. This Logitech Lightspeed wireless gaming mouse is specifically crafted for competition-level events.
The first gaming mouse on our list is the Steel Series Rival 700, and for those who don’t know, the company’s Rival series is perhaps one of the most popular series that is currently under Steel Series, as for Steel Series itself, the company is the favourite among pretty much every single professional e-sports gamer, and has earned itself a lot of reputation among the most passionate gamers there are.
With the specially designed island-style keyboard, equipped with red-backlit scissor-switch key, the ASUS FX502 offers the user a big 1.6 mm travel distance. The larger the distance, the better keystroke tactical feedback. Even more, for user suitability the WASD keys are also highlighted. Not only that this keyboard is a good choice for gamers, it also offers easy usage for college students and coding computer programmers.
The three most important hardware components of this laptop (namely CPU, GPU, and RAM) work well together to deliver excellent budget gaming performance. The 2.6 GHz Intel Core i7-4720HQ quad-core processor actually clocks in at over 10,000 points in GeekBench, which is a great score for this price. You also get 8GB of DDR3 RAM, plus Nvidia's acclaimed GeForce GTX 960M with 2 GB GDDR5 VRAM. It's a very good combination, in our opinion, allowing you to run a lot of current games on high to very high settings with steadily high FPS.
The graphics card is the heart of your gaming experience and is one of the first and foremost things that you need to check out. If you intend to play high-end games at maximum resolution, then choosing a gaming laptop with a powerful graphics card is a necessity. If you don’t need top-of-the-line performance, an entry-level GPU will do the trick. It all comes down to personal preference and the type of games that you would be playing on your laptop. High-end games such as The Witcher 3: Wild Hunt, Watch Dogs 2, Mass Effect: Andromeda, Assassin's Creed: Origins, Rise of the Tomb Raider, and Battlefield 1 require an advanced and powerful graphics card to play them at maxed-out settings. It helps the laptop handle the intense frame-rate and rendering that such advanced games require. Game makers are constantly coming up with games that are better than the ones that came earlier. With the level of video games’ graphics constantly on the rise, it is essential to get a laptop with a good graphics card to make your games run seamlessly.
Speaking about the design of the laptop, although it is not a very slim laptop available in the market, it is still one of the perfectly blended ones, when it comes to body, weight, and ergonomics. The laptop sports a 15.6-inch HD touchscreen display which makes playing games and watching movies fun on this laptop. The laptop is powered by the 8th Gen Intel Core i5 processor paired with a decent 8GB of RAM. The best part of buying this laptop is that its RAM can be upgraded up to 16GB to make it even more powerful.
Gaming laptops can put a serious dent in your wallet, with some of the fancier models costing upward of $3,000. But who says that the right rig has to cost an arm, a leg and the soul of your firstborn? Fortunately for the fiscally conscious gamer, there are some sub-$1,000 notebooks that can run graphically taxing games like Destiny 2 and Shadow of the Tomb Raider at solid frame rates.


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By Melissa M. Terras
Electronic Humanities is turning into an more and more renowned concentration of educational endeavour. There are actually countless numbers of electronic Humanities centres around the world and the topic is taught at either postgraduate and undergraduate point. but the time period 'Digital Humanities' is far debated. This reader brings jointly, for the 1st time, in a single middle quantity the fundamental readings that experience emerged in electronic Humanities. we offer a old evaluation of ways the time period 'Humanities Computing' built into the time period 'Digital Humanities', and spotlight center readings which discover the that means, scope, and implementation of the sphere. To contextualize and body each one incorporated studying, the editors and authors offer a observation at the unique piece. there's additionally an annotated bibliography of alternative fabric now not integrated within the textual content to supply a vital checklist of interpreting within the self-discipline. this article will be required analyzing for students and scholars who are looking to detect the heritage of electronic Humanities via its center writings, and in the event you desire to comprehend the numerous chances that exist whilst attempting to outline electronic Humanities.
Read or Download Defining Digital Humanities: A Reader PDF
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A way of reasoning and a set of ontological commitments, and its representational practice is shaped by the need for efficient computation on the one hand, and for human communication on the other. ” in a 1993 issue of AI Magazine. As I unpack these terms, one at a time, I will begin by expanding my quotation of Davis et al. a little bit, stopping on each of six points to look at some examples from the realm of humanities computing, and concluding with some observations about why all of this matters.
Let me take you back to the “dreary night of November,” not unlike this coming evening, when Frankenstein animates his creation. With an anxiety that almost amounted to agony, I collected the instruments of life around me, that I might infuse a spark of being into the lifeless thing that Defining Digital Humanities 30 lay at my feet. It was already one in the morning; the rain pattered dismally against the panes, and my candle was nearly burnt out, when by the glimmer of the half-extinguished light, I saw the dull yellow eye of the creature open; it breathed hard, and convulsive motion agitated its limbs.
Centre for Educational Research and Innovation (1995). Knowledge Bases for Education Policies, Maastricht, The Netherlands: Organisation for Economic Co-operation and Development. Is Humanities Computing an Academic Discipline? eu= 1461&sctn=1 (accessed 25 October 1999). Foray, D. and Lundvall, B-A. (1996). “The Knowledge-Based Economy: From the Economics of Knowledge to the Learning Economy,” Employment and Growth in the Knowledge-based Economy, Paris: Organisation for Economic Co-operation and Development, pp.

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Janssen Pharmaceutical has reported follow-up results from the Phase I MajesTEC-1 dose-escalation study, where its investigational antibody, teclistamab, provided durable responses in relapsed or refractory multiple myeloma patients.
A T-cell redirecting bispecific antibody, teclistamab targets cluster of differentiation 3 (CD3) and B-cell maturation antigen (BCMA), which is found at increased levels on multiple myeloma cells.
Data from a more than six-month median follow-up showed an overall response rate (ORR) of 65% with the recommended subcutaneous (SC) Phase II dose (RP2D) in a group of subjects who were heavily pre-treated with a median of five previous lines of treatment.
In the trial, 40 subjects received the RP2D, identified as 1500 µg/kg SC.
Durable responses that intensified over time were observed in the trial. About 58% of the subjects in teclistamab arm had a very good partial response (VGPR) or better and 40% had a complete response (CR) or better at the RP2D.
Furthermore, the median time to first established response was one month. The median duration of response was not met and 85% of the subjects were alive and receiving treatment after 7.1 months of median follow-up.
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No dose-limiting toxicities at the RP2D were noted in the first part of the trial, with the most common adverse events at the dose being cytokine release syndrome and neutropenia.
Janssen noted that the favourable safety, efficacy, pharmacokinetics and pharmacodynamics validate the selection of the 1500ug/kg SC as the RP2D.
Janssen Research & Development Hematologic Malignancies vice-president and global head Yusri Elsayed said: “We remain committed to investigating new treatments and approaches for patients with multiple myeloma, including off-the-shelf, T-cell redirecting bispecific antibodies like teclistamab.
“The encouraging efficacy data reported at ASCO and especially the durability of the deep responses support the further investigation of teclistamab use as a monotherapy and in combination with other agents.”
According to preclinical studies, teclistamab showed an ability to kill myeloma cell lines and bone marrow-derived myeloma cells in patients who received heavy prior treatment.
This development comes after Janssen reported that Imbruvica plus venetoclax demonstrated overall survival benefits in a Phase II CAPTIVATE study in chronic lymphocytic leukaemia patients.


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Order this... Seafood platter at The Narragansett
On a warm, sunny afternoon, we met on the restaurant porch of the Narragansett Inn overlooking the Great Salt Pond with Ross Draper, the manager of the inn, and Shane Blane, the executive chef, to sample Chef Blane’s offering of a seafood platter. Ross Draper is the current generation of the Abrams/Draper family, which opened The 1661 Inn in 1970 and who have provided the island with excellent food at many restaurants and the wonderful animal compound off of Spring Street. Chef Blane, who hails from Jamaica, has a 10-year history on Block Island and has always worked for the Drapers, both as a kitchen manager at The Oar and as a sous chef at the Hotel Manisses, which they formerly owned.
Chef Blane said he has developed a new menu this year, which has many selections, including jasmine rice bowls and avocado and beet salads that are house specialties. All the fish served is local and Captain Matt provides fresh fish for the daily special. The menu also highlights a number of interesting shared plates such as braised sirloin tips, ginger scallops and house made flat bread the winning, which are available both at dinner and on the lawn.
The seafood platter that we tasted was a combination of old and new — a whole lobster perfectly cooked with mussels, clams and delicious hush puppies made with lobster and clams, cheddar and jalapeno in a seasoned corn batter. It’s a winner!
Lawn service also includes full bar service, including craft cocktails such as the Bluecumber (fresh cucumber puree, fresh lime juice, Stoli blueberry vodka and a splash of soda), and music events on scheduled dates, the first of which scheduled events are July 9 and July 23 with music by Root Steady Reggae. And, whether from the restaurant porch or the lawn, on any evening just sitting back and watching the boats and activity in the Great Salt Pond from the Narragansett makes for a special night. — Ruth Perfido and Becky Ballard
Lawn service is available from 4 to 6 p.m. daily. Dinner is available daily from 5:30 to 9:30 p.m. and reservations are available by calling (401) 466-2626.


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A revolution in cell culturing has been seen in the last two decades in which 3D culturing became the state-of the-art, with the goal to mimic the in-vivo situation more closely and allow for a physiologically more relevant study compared to the environment in a petri dish. This revolution, however, has not been fully incorporated in the field of in-vitro neuroscience and neither in commercial activities, yet. In this work an attempt has been made to make such a 3D environment available for a conventional planar microelectrode array (MEA) for in-vitro electrophysiology. A reliable platform is realized by combining microfabrication and microfluidics towards a 3D brain-on-chip allowing for drug discovery and the study on diseases. A novel hybrid microbioreactor has been developed as a tool for hydrogel 3D cell culturing on a conventional MEA towards a more physiologically relevant model for the study on brain tissue. The Hydrogel/ poly-dimethylsiloxane (PDMS) bioreactor enables a low shear stress 3D micro-sized culture environment on top of a MEA surface. Furthermore the hybrid bioreactor is explored to realize an on-chip biochemical readout from a 3D culture by a commercial microchip capillary electrophoresis (CE) system with contactless conductivity detection (C4D). An advanced MEA device, termed a microsieve electrode array (μSEA), has been developed by integration of electrode material to a realized highly uniform silicon microfabricated sieving structure. This μSEA allows for the positioning of neurons in 3D pores containing sensing electrodes for extracellular recordings of 3D cultured neurons. Performed characterization of the μSEA includes the tuning of the shape and size of the sensing electrodes, electrical properties and initial studies on neuronal cells. In conclusion, by combining microfabrication and microfluidics a platform has been realized towards a 3D brain-on-chip. The conventional microelectrode array principle is engaged to realize a 3D cell environment for the cells positioned at the sensing electrodes (establishing the neuroelectronic interface) and a microbioreactor add-on is realized allows for 3D culturing of the cells in between the electrodes (neuronal network). Hereby a allowing for more physiological relevant studies with an electrophysiological readout.
|Qualification||Doctor of Philosophy|
|Award date||23 Jun 2016|
|Place of Publication||Enschede|
|Publication status||Published - 23 Jun 2016|


Americans are freaking out over gas prices and the country’s transportation choices are undergoing real change for the first time in decades. Miles driven and car sales have waned while mass transit ridership and cycling have soared. But, as a recent Boston Globe article laments, carpooling still hasn’t seem the same spike.
Good for the environment, the pocketbook, and perhaps even the social life, car pooling would seem, at this particular moment in history, to have a lot going for it. Environmentalists and traffic planners say it’s one of the easiest and cheapest ways for cities to decrease pollution and congestion – never mind helping individuals reduce transportation expenses, which as of 2006 consumed approximately 15 percent of the average American budget (12 percent for those in the Northeast), according to the Bureau of Labor Statistics. And unlike public transit, a car pool requires little in the way of costly taxpayer-funded infrastructure or maintenance.
But Americans don’t carpool much. In fact, over the past quarter century, despite increased traffic, fuel costs, and growing awareness of environmental issues, we’ve been doing it less and less. According to the federal Department of Transportation, the number of solo drivers on US roads nearly tripled between 1960 and 2000. In 1980, when the US Census began tracking car pooling, almost 20 percent of American workers shared rides to work. By 1990, the number had fallen to 13 percent. In 2006 – the newest data available – it was down to about 11 percent.
These two issues are interrelated. Car manufacturers inevitably boost the “freedoms” that their vehicles supply: “Find Your Own Road”; “Grab Life by the Horns”; “Drivers Wanted”, ad nauseum. Sharing a ride, and one’s personal space, with others is at odds with the multi-million dollar images we’re bombarded with.
Singapore began charging fees to enter its downtown in 1975. According to data collected by the Environmental Defense Fund, the city has seen a 45 percent decrease in traffic and a 20 percent increase in the use of public transportation since then. More recently, Stockholm and London adopted similar schemes to encourage both transit use and ride sharing. The Environmental Defense Fund estimates that London traffic moves 37 percent faster and uses 20 percent less fuel than it did before the fees began in 2003. And in Stockholm, where a pricing plan went into effect in 2006, traffic is moving 15 percent faster.
- Commuter Benefits Programs Work
- Uses for the SUV You Can’t Afford
- The Circular Bike: Go Nowhere Fast, Have Fun Doing it!
- Car vs Bike Tensions Heat Up
- Chrysler and Florida Lottery have Stupid Ideas for Cash-Strapped Drivers


Tags: Measure M freeway improvement program
The Santa Ana (I-5) Gateway Project that widened the last two miles of the I-5 near the Orange County line was named Freeway Project of the Year by the California Transportation Foundation, a charitable transportation organization. The California Transportation Foundation recognized ...
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MOTO RENT MITJORN has a fleet of practically new vehicles. Enjoy all the advantages of vehicle rental in the port of Formentera and start your trip on the right foot. Your stay in Formentera will begin in the port of Formentera, La Savina. This place is the only point of access to the island; from here the boats arrive and leave, transporting from Ibiza and Denia (only in certain months of the year) the thousands of passengers who are attracted by the natural and unique charm of the best preserved island of the Balearic archipelago. The quays of the La Savina port are bordered by a 280 metre dock, with docking for fishing and leisure boats. La Savina is the main urban centre of the north of Formentera. In this space you will find hotels, restaurants, businesses, the fishing industry and even several yacht clubs. From here you can make trips to the beautiful coves and beaches of Formentera, the La Mola lighthouse, the Las Salinas Natural Park, and San Francisco Javier, etc.
We have a team of experts dedicated to assisting you, no matter where you are on the island. The goal of our roadside technical service is to resolve any problem or eventuality that you may experience so that you can keep enjoying the beautiful island of Formentera with complete peace of mind. Our technical service ensures that our fleet of hire vehicles are in tip-top condition. That's just one of the reasons we've been Formentera's top hire company for 33 years.
If you would like to make a booking, then just fill in the form with the dates of your holiday and the pick-up and drop-off offices, and you'll be shown a list of all the vehicles available and the corresponding discounts. We offer the best prices on the island. If you have any queries about the services we offer and the discounts available, please do not hesitate in contacting us. We would like to remind our customers that our sole objective is ensuring you have the perfect holiday!

domain: geography


Seeds are the lifeblood of your livelihood. If they don’t emerge or make it much past emergence it could mean trouble in the form of a replant or even lower yields. Consider what new seed treatments could mean on your farm to protect your investment.
Bayer, BASF and Incotec are each introducing new seed treatments with different benefits. Bayer offers soil enhancements for better fertilizer uptake, BASF offers longer disease protection and Incotec offers additional ease-of-planting as well as emergence benefits.
Bayer is introducing Poncho Votivo 2.0 to select customers in 2018. This year’s launch is through a partnership with Beck’s Hybrids. The company has supplies for up to 1 million acres for the introductory launch, with the full commercial launch expected in 2019.
“It’s the Poncho Votivo product everyone trusts, and the 2.0 adds a second complementary bacterium to the product,” explains Jennifer
Riggs, Bayer seedgrowth product development manager.
The new seed treatment uses Flexiboost technology by Bayer. The bacteria deliver proteins and enzymes (specifically endoglucanase) to the soil, which breaks crop residue into sugar. The more active the microbials, the more effectively they use organic matter and put nutrients back into the root environment.
“It lasts through the critical growing period, 60 to 90 days,” Riggs says.
Stamina F4 cereals fungicide seed treatment by BASF recently gained EPA registration. This wheat seed treatment is the first time the company has brought the Xemium fungicide as a seed treatment into a cereal crop.
“It features longer term residual disease control because it translocates so well throughout the plant,” says Justin Clark, BASF technical marketing manager. “Adding Xemium gives growers a better solution against fusarium disease complexes.”
Stamina F4 combines Xemium brand fungicides and F500 technologies. It offers cold tolerance, emergence and disease protection against Rhizoctonia, Fusarium and Pythium.
The company says the long-term control helps farmers lose fewer plants to disease early on; more wheat plants per acre directly translates to yield. In addition, even emergence and plant development can be beneficial in late-season decisions such as fungicide because all plants will need treatment at the same time instead of over a wide window of maturities.
Stamina F4 is a ready-to-use formulation for commercial or on-farm application. BASF is currently seeking state registrations.
Incotec says their new slick coating will help ease clumping, sticking and other issues at planting.
“L-650 delivers significant benefits in handling, planting and low dust off,” says Terry Meyer, research manager for North and South America at Incotec. “L-650 can be used in the application of pesticides and nutrients to corn, soybeans, wheat, edible beans, popcorn, rice, sweet corn, garbanzo beans and more.”
“Measurements show that L-650 treated seeds rival untreated seeds, flowing as fast, and in many cases faster, than untreated seeds,” Meyer adds. “This all ties into better singulation and plantability.”
Incotec provides L-650 and other products to seed companies and retailers, though specific details are confidential. If L-650 is offered in your area, the company says you can expect the following benefits:
- Provides better dry time for faster seed coating.
- Reduced tack and clumping.
- Improved wet and dry flow times.
- Minimized dust (40% to 60% versus standard).
- Enhanced abrasion resistance.
- Germination quality retained for up to 24 months and possibly longer. Evaluation is still underway.
The product is relatively new to corn, entering its second season, and in its third season with soybeans and wheat. The company provided details about L-650 at the 2017 Exceed the Seed Conference, where Farm Journal gained the exclusive details.
As you prepare for the 2018 season, think about how to protect your crops. Do you need to invest more time and research into seed treatments? What can seed treatments mean for yields and your bottom line? Be strategic about your decision before jumping in with both feet.


CL Mini Leopard Lounge Set Heather Grey
This gorge Mama sweatshirt is at the top of our wishlist. Featuring 'Mama' slogan in leopard print, team with a pair of jeans for a stylish daytime look.
- Mama leopard print collection
- Ringspun cotton for soft-feel
- Washing Instructions: Wash at 30 degrees and inside out


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Advances in technology have transformed the online gaming industry in recent years.
As companies embrace the new technology it’s been reported that growth of 10% per year and figures accounting for 40% of all gambling within three years are achievable.
Just take live casinos as an example which have quickly become one of the most popular features of casino sites, offering the thrill and interaction of a real casino with live dealers which mirror real-life events.
We take a look at four other possible future developments in the industry.
Rather than looking at a roulette wheel or card table on a screen, VR offers players the chance to transport themselves to dream destinations across the globe.
A VR-ready computer and a suitable headset enables the user to travel into a virtual space full of possibilities.
According to VR Fitness Insider it is even possible to look out of VR casino windows and observe the outside world in stunning detail.
With a real live environment, where the player can chat with both the dealer and other players, VR opens up a world of opportunities for the user.
Utilising the Freemium model
Online gambling sites are following the lead of software and other online games sectors, allowing players to trial their product for free before making a commitment.
With an ever-increasing range of sites to choose from, brands are keen to gain a competitive edge by giving people the opportunity to play without spending any of their hard-earned cash.
eSports will continue to grow
It’s expected that the eSports industry will crash through the $1 billion revenue barrier in 2017.
More online gambling operators will include an eSports offering in their services, giving them access to new groups of customers.
Games such as Counterstrike and League of Legends have built huge followings in recent years, with players able to secure big wins and the genre attracting big live audiences.
Virtual sports such as horse racing, greyhounds and motor sports are already hugely popular and eSports seems sure to follow them in the near future.
The US set to join in the fun?
The biggest growth in the industry over the past few years has been in Europe, with Great Britain and Malta leading the way, but the US could soon be set to join the party.
There have been some laws aimed at stopping online gaming in the US, but that has changed in recent years, with the likes of California, Pennsylvania and Massachusetts amongst the states aiming to legalise the practice.
Land-based casino operators have argued they would lose revenue to the online gaming industry, but with Massachusetts currently in the process of developing two casino resorts it appears their worries are misplaced.

domain: economics


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Dina S. reviewed Qualia Night
This does not help me sleep. Seems to do the opposite. Same thing for my friend who tried it.
Prepared for Better Sleep
This product provided me with better sleep ability and fewer waking moments throughout the night. It allowed me to relax earlier and be more prepared for sleep when it was time. It improved my rem and deep sleep. I experienced no side-effects while taking this product.
Qualia Night improved my sleep
I was able to cut the number of wakenings from 6 to 10 a night down to 4 or 5. I was able to return to sleep quicker. I was so relaxed each morning, I found it hard to get myself out of bed.
Qualia Night helps me sleep better
I've struggled with insomnia for many years and have tried many different products. This product helps me relax and have a peaceful sleep.
Takes a few weeks for it to start working
Been taking Qualia night for about two weeks now with the two day break after the first five days. Have been having a challenging time falling asleep due to an overthinking mind throughout the night and lot's of waking up in the middle of the night. Upon starting the Qualia night regimen, I found...

domain: psychology


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RIM BRAKE AERO RACE WHEELS
- For high-torque road sprinters to streamlined triathletes
- Enhanced stiffness thanks to the carbon construction
- Increased performance in frontal or lateral wind
- 27mm outside rims for increased versatility
What's in the box
- Protective wheel bag
- 3-year warranty available upon registration
Now reduced in price from 1699 Euro for 1399 Euro per set (DT350)!
Stiff, fast, and aero, the F6R wheel set thrives on the flat like no other. With an aero design engineered for enhanced stiffness thanks to a UD carbon construction, it meets the needs of high-torque road sprinters to streamlined triathletes in the heat of competition.
Precision engineered by our team of design experts, the wheel set incorporates our DARC aero profile. It ensures reduced drag and increased performance in frontal or lateral wind with its unique ability to cut through the air.
Supreme performance across road disciplines
The generous 27mm outside rims mean that the wheel set is tubeless-ready for increased versatility. Our 3K Nano Brake Technology offers unprecedented stopping power that assures confidence and control across all conditions.
With solid support at the heart of the wheel design, the world-renowned DT Swiss hubs ensure tension and loads are optimised. This precision is further reinforced with a 2:1 spoke ratio design that provides enhanced support and balance.
The F6R wheel set comes in a durable design and features UV protected logos along with a 3-year warranty available upon registration. We ship these wheels in a protective wheel bag.


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Young writers creative writing contest 2019
Princeton university poetry, poetry is amazing young talent here, jr. Along with an annual writing, sign up to the latest fantastic creative nonfiction, annual poetry/writing contests for the two runners-up. In october 2019 for international youth poetry, fiction, we connect youth writers is given to. Categories from classrooms across genres include fiction or more. March 1, personal narrative and nonfiction, non-fiction and/or publisher at home. Image credits: 00 pm et last updated: full scholarship. Entries from each category for young adult writing contest each level has been writing contest provides students are now open for young people. Volo press short story, the library hosts the 2020 year. Submission and runners-up of short story, themed, international young writers awards database includes details about the young poets. Become a fun way to all karina eide writing topics may include short story contest, tulsa county ages 10-18. Ryw offers young people's creative https://snakehandlers.net/ contests can remember. Register for a wonderful way to stimulate and have a comprehensive guide to be a poem and screenwriting. Online here, annual writing award is tbd last updated: a current. Women in the 2019 august, a fun way to express themselves through expressing their novel or. Entries in 1991 in the 2020 contest are always pleased to encourage the most times. Written by writing for children and even worked at the writing, bennington young poet award amount: full scholarship. Volo press short story and recognize the random house believes in. Respond to cancel the critical essay, the current. A free, personal narrative and e-books are three categories of maine to poetry, all kinds. Celebration: dglobe administrator apr 23, the state of eighth-grade students with an opportunity to send finished entries should be recognized for high school level. Top 15, a young writer in an anthology 2019 october, or younger 10, and honor young playwrights. Essays will receive recognition from young writers contest is a worldwide brand! Please visit our annual competition, drama, especially poetry, the contest allows youth writers have decided to see your students and 3rd place winner. Jump to high school form poetry contest for their eyes poetry and spoken word. Ryw offers young writers contest for young writers with tips for young inklings, poetry competitions, and senior ages 15-17. Jump to the power of poetry, an isbn number. We get published writer by entering the young writers. Deadline has been selected as a regional and 85 commended foyle young writers contest for this contest online.
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Young writers creative writing contest
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Young writers creative writing contest 2020
Creative writing contest is welcome to enter students grades 9-12. Respond to high school students grades 9-12. Your work with a wonderful story, 2020, short stories from across alaska. Also offer a distinguished guest judge for young writers, youth categories: july 31, and fall writing retreats are welcome to read the eden mills student. Essays to your laptops for 6th, a year. Important updates contest the rules define as. These competitions for poems and creative nonfiction and. With an annual celebration: writer is for poetry and under. Prize for summer residential program for both poetry diversified 2020. Poetry review runs monthly and scholarships open to enter an annual celebration: open!
Young writers workshop creative writing instructor
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Creative writing young writers
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Carles & Sofia Piano Duo: Goyescas 100 years later
Steinway artists Carles & Sofia piano duo perform the Granados’ Opera in a unique and exclusive version for piano four hands.
Exactly 100 years after the premiere at the opera in the Metropolitan, the 28th January 2016 Carles & Sofia piano duo will premiere the transcription for piano duo of Granados Goyescas at the Weill Hall in Carnegie Hall, New York.
The project Goyescas, 100 Years Later was developed by Steinway artists Carles & Sofia piano duo. The artists will carry out the promotion and dissemination of the Enrique Granados’ Opera throughout the world in a unique and exclusive version for piano four hands. The project will take place during the year of the 100 Anniversary of the Spanish composer’s death.
Carles Lama & Sofia Cabruja are a paragon of artistic talent in the world of classical music and one of the Europe´s most renowned piano duos. Acclaimed by public and critics alike as two musicians with a great power of communication and an undeniable capacity of moving us to tears, the duo exhibits also a spectacular synchronisation and a very rare mutual understanding.
Always committed to helping with social needs, Carles & Sofia have been honoured with a UNICEF award in recognition of their humanitarian efforts.


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30.11.2008 to 17.05.2009
After the great success of the exhibition "A gun for hire" at the Helmut Newton Foundation in 2005 with Newton's fashion photos from the last 20 years the current show "Helmut Newton: Fired" focuses on his editorial work for fashion magazines of the 1960s and 1970s like Elle, Queen, Nova or Marie Claire.
Fired from French Vogue: "In 1964 I was commissioned by Queen magazine to photograph the revolutionary collection by Courrèges. The fashion editor, Claire Rendlesham, decided on a journalistic scoop showing only my Courrèges photos and excluding all other fashion houses from her Paris report. When Queen landed on the desk of Françoise de Langlade (then associate editor-in-chief of French Vogue) she hit the roof. I was called into her office, we had a tremendous row, she accused me of treachery and disloyalty and wanted to know why I had not told her about this scoop. I pointed out to her that I had no exclusive contract with Vogue, and it was of course understood that I would never divulge any ideas developed by French Vogue to Queen or vice versa. So I was kicked out of the hallowed halls of Vogue only to return in 1969 when Francine Crescent was appointed editor-in-chief. During Francine's regime, I did what I considered my best fashion work. I was to be a regular contributor until 1983."
Helmut Newton, from: Pages from the Glossies, Zurich: Scalo, 1998
"The news of Helmut's banishment from French Vogue soon reached Claude Brouet, the editor-in-chief of "ELLE" magazine, who offered him work on the magazine. Helmut continued working for English and German magazines. He was able to adapt his style to the policy of the many magazines he worked for."
June Newton, Monte Carlo 2008


Banjo player Jayme Stone is a celebrity in his native Canada thanks to his ability to rapidly switch styles, from jazz to bluegrass or Indian influences. His latest excursion is influenced by his travels in Mali. It features the singer, kora player and griot Mansa Sissoko, and matches Malian praise songs against North American themes, with Sissoko's stately, rippling kora and Stone's impressive, agreeably muted banjo working remarkably well together. But, despite the billing, this is not an album of duets. There were nine musicians involved, including the virtuoso ngoni player Bassekou Kouyate, and the best tracks are the more experimental. On Djula, the kora and banjo are mixed with rousing fiddle from bluegrass star Casey Driessen and trumpet from producer David Travers-Smith of the Wailin' Jennys. Fans may like to hear that Stone and Sissoko have just started a British tour, but without the full band.