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Scientists have armed immune cells with a new surface molecule. This causes the cells to respond particularly aggressively when they encounter a protein that tumors actually use to camouflage themselves from the immune system. Researchers from the Helmholtz Zentrum München and various partners introduced the method in ‘Cancer Research’.
With numerous different entities and millions of people affected, cancer continues to be one of the most prevalent diseases around the world. Scientists are working to find new treatment possibilities, and have been concentrating on the body’s own immune system for some time.
“Because cancer emerges from the body’s own cells, it is usually difficult for the immune system to distinguish good cells from bad ones,” explains Prof. Dr. Elfriede Nößner, head of the Tissue Control of Immunocytes Research Group at the Helmholtz Zentrum München. “But there are ways to support the immune system in recognizing and combating cancer cells.”
Focus on T-cell therapy
One approach is the so-called adoptive T-cell therapy, which involves removing immune cells from the body and genetically arming them. The cells are given new structures on the surface that accurately lead them to the cancer cells.
One limitation in this form of therapy is that the binding between the immune cell and the cancer cell is often somewhat weak. “Although this binding can be artificially strengthened, doing so also increases the risk of unwanted binding to healthy structures in the body,” explains study leader Nößner. She and her team were therefore searching for a different way to improve the defense provided by the immune cells.
Attack instead of sleep mode
In the current work, the researchers present a new surface molecule which comprises two halves. On the outside, it preferentially binds to the PD-L1 molecule, which tumor cells often form in order to thwart the attacking immune cells. On the inside of the T-cells, however, this binding does not activate a sleep mode (which the natural protein would do), and instead activates the T-cell’s killer program, making it especially aggressive. Experimental models showed that T-cells armed in this way proliferate more strongly in the tumors and destroyed more tumor cells.
The next step will be to confirm the findings in clinical studies. “If that step succeeds, the approach would enlarge the arsenal of T-cells suitable for adoptive T-cell therapy,” Elfriede Nößner states. “This could not only make the treatment more effective but would allow it to be used in more patients in the framework of personalized medicine.”
The work was the result of close cooperation with the team headed by Dr. Matthias Leisegang from the Institute of Immunology at the Charité Berlin Buch Campus and Prof. Dr. Dolores J. Schendel, CEO and CSO at Medigene AG. The authors Ramona Schlenker, Luis Felipe Olguin Contreras, Anja Disovic and Julia Schnappinger attend the Helmholtz Graduate School Environmental Health, or HELENA for short.
Schlenker, R. et al. (2017): Chimeric PD-1:28 receptor upgrades low-avidity T cells and restores effector function of tumor-infiltrating lymphocytes for adoptive cell therapy. Cancer Research, DOI: 10.1158/0008-5472.CAN-16-1922
The Helmholtz Zentrum München, the German Research Center for Environmental Health, pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. The Helmholtz Zentrum München is headquartered in Neuherberg in the north of Munich and has about 2,300 staff members. It is a member of the Helmholtz Association, a community of 18 scientific-technical and medical-biological research centers with a total of about 37,000 staff members. http://www.helmholtz-muenchen.de/en
Contact for the media:
Department of Communication, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg - Tel. +49 89 3187 2238 - Fax: +49 89 3187 3324 - E-mail: email@example.com
Prof. Dr. Elfriede Nößner, Helmholtz Zentrum München - German Research Center for Environmental Health, Immunoanalytics - Research Group Tissue Control of Immunocytes & Core Facility, Marchioninistr. 25, 81377 München - Tel. +49 89 3187 1303 - E-mail: firstname.lastname@example.org
http://www.helmholtz-muenchen.de/en/press-media/press-releases/all-press-releases/index.html - read more news of Helmholtz Zentrum München
Sonja Opitz | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
NYSCF researchers develop novel bioengineering technique for personalized bone grafts
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Pollen taxi for bacteria
18.07.2018 | Technische Universität München
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
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18.07.2018 | Health and Medicine


text: Seismic stratigraphic analysis of the continental shelf north of the Falkland Islands confirms that it is dissected by a significant extensional fault system that broadly defines the North Falkland Basin. The basin comprises a series of extensional subbasins that developed during two distinct rift episodes. Analysis of structural styles shows that while extension occurred predominantly on a series of planar normal faults with changes in rift polarity in northern areas, the southern portion of the basin has listric faults that sole out along preexisting thrusts. After rifting, the basin largely underwent postrift thermal subsidence with the passive infill of remnant topography; however, evidence exists for at least two uplift events affecting the postrift sediments. The earlier period of uplift tilted the basin to the south, resulting in the formation of a southerly prograding forced regressive wedge; the later episode of uplift tilted the basin northward, resulting in truncation of earlier strata and minor compressional reactivation and inversion in southernmost parts of the basin. The later tilting allows for the possibility that the original rift system once extended across the Falkland Islands. Although the lack of well control does not permit a comprehensive assessment of hydrocarbon plays, the seismic data do at least demonstrate the trapping potential of the basin. Interpreted structural and depositional styles found within the prerift, synrift, and postrift sequences are similar to those found in proven hydrocarbon provinces such as the North Sea and the Gulf of Suez. The success or failure of the frontier hydrocarbon province thus is likely to depend upon factors other than structural ones.

domain: geography


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Birthname: Carly Rae Jepsen
Born: Nov 21 1985
Carly Rae Jepsen (born November 21, 1985) is a Canadian singer and songwriter from Mission, British Columbia, and later based in Vancouver. In 2007, she placed third in Canadian Idol season five’s competition. Jepsen independently released her debut album, Tug of War, in 2008. In 2011, she released the single “Call Me Maybe”, which was followed in 2012 by her debut EP, Curiosity, and her second album, Kiss.
This article uses material from the Wikipedia article “Carly Rae Jepsen“ which is released under the Creative Commons Attribution-Share-Alike License 3.0.

domain: celebrity


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domain: hobby


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The profile for attorney Binder & Binder is still pending to be claimed. ListaLegal lawyer profiles are agreggated from the State Bars' public records and other online attorney listings.
ListaLegal's directory listings include lawyers in all 50 states. Profiles may include contact information, practice areas, client reviews, affiliations, peer endorsements and lawyer-submitted legal guides.
Binder & Binder, is this your profile?
Claiming your profile is free and it will help you update your Law Firm information. Highlight your practice areas, phone number and website address. This is the perfect place to showcase your experience working with the Hispanic community, awards, pro-bono work and more.
Overall, how do you rate Binder & Binder?
Posted by Demarius Mayes
I just want to say that Binder and Binder won my case back in 2015.. Binder and Binder Law firm is a straight forward firm and they care about you and when they say they will work for you they mean every word. All you have to do is do everything they tell you do. I thank you Binder and Binder for all that you have done.
Posted by BullaTeairraThe Queen of Rap Briefs
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domain: law


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Chart of Accounts
A chart of accounts(COA) is a must have tool for any company. If you are not familiar with the concept, COA is a list of all accounts that are registered in the EasyERP. They are used to define each class of items and procedures for which money or equivalent is spent or received.
This chart is used to organize the finances of the company and to separate expends, revenue, assets, and liabilities in order to provide best possible information of the financial status of the enterprise.
In the EasyERP Accounting module accounts are defined by an identifier. This means that there can not be two or more accounts with the same number. Furthermore, you can tell what type of the account is which, just by looking at his identifier. The first two or three digits are the keys, depending on the segregation of your COA. This two or three digits can tell you in which of the accounting categories does this particular account belong. You can create new categories of the COA in the Settings -> Accounting -> Accounting Categories.
So to open up the chart of accounts menu press the corresponding button in the Accounting menu, as you can see here:
When you do so the list of all accounts registered in the EasyERP accounting module will be shown. They are displayed in the form of a table, with next columns:
- Code - the identification number of an account
- Account - a short description of the account, it is also its name
- Currency - this show will display what currency does the account use. Currency is only shown for the real bank accounts, every other account is set to use the default currency of the EasyERP
- Type - this field will show what accounting category does this particular account belong to.
In the COA menu you have four possible ways to interact with accounts:
- View, this is self-explanatory, you can remind yourself what accounts are present in your the EasyERP accounting module
- Creating a new one, you have the power to create your own accounts, according to your company’s needs. We will provide a detailed manual on how to do this here
- Deleting an account is one of the possible course of action. Like any other entity in the EasyERP, any account can be deleted. You can find further details on how to delete an account here
- Edit the account. You can change the code, name or the type of an account. To do so tap on the field you want to change and correct it as you want, afterward tap the save button at the top of a table
To change the type of as already existing account in the COA, all you have to do is click on the type of the account, and then reassign it to another accounting category by clicking on it in the drop-down list. To save the changes press the Save button at the top of the table. As an example here is the whole process:
For a more comfortable view of the COA, you can sort all accounts by any field. In order to do so, to sort all accounts by a determined field, simply press on the column identifier at the top of the menu, to sort the table in a reverse order tap there again.
Create an account
In order to correctly do the procedure of accounting in your company using EasyERP Accounting module, you will have to create a lot of accounts, that will define each class of items and procedures for which money or equivalent is spent or received. But at first, you will have to create accounting categories. To do so go to Settings -> Accounting -> Accounting categories.
Now to begin the procedure of creating account tap the New button at the top of the menu. This window will open:
As you can see there are three fields that you will need to fill in order to create an account:
Account name field is active and ready right after you have pressed the New button. Here you can type in the name of the account. In order to simplify your accounting experience afterward try to create unique and exact names, that will define the source or cash or procedures for which money is spent. The maximum characters allowed for the account name in the EasyERP accounting module is 45.
Account category is selected from the drop down list of all registered in the EasyERP accounting module categories. You can use the search tool at the top of the list if you have trouble finding the necessary category. This option will not only decide to what of your categories will the new one belong but also it determines account’s behavior.
Account code please input the numbers that will represent this account. Note that you can use only digits and only 14 of them. You are free to choose any number you want, but be sure that this number is unique. There cannot be two or more account with the same code, every one must be unique. Also as a good accounting practice, you should name them according to your COA, this means that you use first digits of the corresponding category and then add some to identify your account.
After you have completed all the fields press Create to finalize the creation of an account or Cancel if you want to dismiss any information you have inputted.
Delete an account
The process of deleting the account in the EasyERP accounting module is really simple but can lead to a number of difficulties. When you delete an account the system removes it from the COA, but if you have any operations tied up to that account then you will have a problem monitoring those procedures. Because the journal entry will not be deleted, this means that the journal entry will miss one of the accounts. If you are determined that you want to delete an account please make sure that there are no documents in the EasyERP that refer to it.
To delete an account you must do the same actions as with deleting any other entity in the EasyERP. Select an account by tapping on the checkbox to the left of the one you want to remove. Then press the Delete button at the top of the table, here’s an example:View the original page

domain: finance


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Golden Corral Holiday Glazed Ham Meal
When it comes to celebrating the holiday season with a delicious and convenient meal, Golden Corral Holiday Glazed Ham Meal is a standout option.
Whether you’re hosting a festive gathering or simply looking for a hassle-free and flavorful holiday dinner, this article will guide you through the enticing world of Golden Corral Holiday Glazed Ham Meal.
From its history to the ingredients and preparation, we’ll explore everything you need to know to create a memorable holiday feast.
What is Golden Corral Holiday Glazed Ham Meal?
Golden Corral Holiday Glazed Ham Meal is a special offering from Golden Corral, a renowned restaurant chain known for its buffet-style dining experience.
This holiday meal package features a succulent glazed ham, complemented by a selection of mouthwatering side dishes and delectable desserts.
With its robust flavors and generous portions, this meal is designed to bring joy and satisfaction to holiday gatherings.
Ingredients of Golden Corral Holiday Glazed Ham Meal
The Golden Corral Holiday Glazed Ham Meal is crafted using carefully selected ingredients to ensure a delightful culinary experience.
The main star of the meal is the premium ham, which is carefully glazed to perfection.
Alongside the ham, the meal includes an array of classic side dishes such as mashed potatoes, green bean casserole, and sweet corn.
To complete the feast, a selection of delectable desserts like pumpkin pie and apple crisp is also included.
How to Prepare Golden Corral Holiday Glazed Ham Meal
Preparing the Golden Corral Holiday Glazed Ham Meal is a straightforward process that guarantees a hassle-free holiday dinner. Here’s a step-by-step guide to help you:
- Preheat your oven according to the instructions provided with the ham.
- Remove the packaging from the ham and place it on a roasting rack in a baking dish.
- If desired, score the surface of the ham in a diamond pattern for an added aesthetic touch.
- Apply the provided glaze generously over the entire surface of the ham.
Cover the ham loosely with foil and place it in the preheated oven.
- Bake the ham according to the recommended cooking time, ensuring it reaches the desired internal temperature.
- Once cooked, allow the ham to rest for a few minutes before slicing and serving with the accompanying side dishes and desserts.
To enhance your Golden Corral Holiday Glazed Ham Meal experience, consider the following serving suggestions:
- Arrange the sliced ham on a platter, garnished with fresh herbs for an appealing presentation.
- Serve the side dishes in separate bowls or on a buffet-style setup to encourage guests to customize their plates.
- Offer a variety of condiments such as mustard, cranberry sauce, and honey glaze for guests to choose from.
- Pair the meal with a selection of festive beverages like sparkling cider or mulled wine.
- Create a warm and inviting atmosphere by decorating the dining area with holiday-themed table settings and centerpieces.
The Perfect Holiday Meal
The Golden Corral Holiday Glazed Ham Meal has all the elements of a perfect holiday feast.
From the succulent glazed ham to the comforting side dishes and indulgent desserts, it offers a complete culinary experience that delights the senses.
By bringing together family and friends to savor this delicious meal, you can create cherished memories.
The Golden Corral Holiday Glazed Ham Meal is a delectable choice for anyone seeking a hassle-free and mouthwatering holiday feast.
With its rich history, thoughtfully selected ingredients, and straightforward preparation, it brings joy and satisfaction to gatherings during the festive season.
By following our serving suggestions and incorporating the tips provided, you can create a memorable holiday dinner that will be cherished by all.
Frequently Asked Questions (FAQs)
Yes, Golden Corral often offers takeout options for their holiday meals. It’s best to check with your local Golden Corral for availability.
Unfortunately, the side dishes are typically pre-selected and cannot be customized. However, you can always add your own personal touch by preparing additional side dishes of your choice.
The meal is usually designed to serve a specific number of people, which can vary depending on the package you choose. It’s best to check with your local Golden Corral for serving size information.
Golden Corral holiday meals primarily focus on ham as the main centerpiece. However, they may offer alternative options for vegetarians or vegans. Contact your local Golden Corral for more information.
Golden Corral typically offers the glazed ham as part of the complete holiday meal package. However, it’s advisable to inquire with your local Golden Corral if they offer the option to purchase the ham separately.

domain: food


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Panto time came to Pocklington when the award-winning Wolds Wonders performed their latest production, ‘Cinderella’, a wonderfully traditional pantomime with all the much loved and familiar characters and story but with the Wolds Wonders’ individual touch.
From the first oyez to the wedding scene, we were treated to a fun-filled and enjoyable afternoon.
The actors gave a confident and assured performance which was a credit to their talents and to the excellent directing by Frances Kelly and the volunteers, a few of which took part, but it was mainly the company who led the action.
We were treated to a beautiful solo by Jason Cresswell and Peter Rand showed his now familiar touch in his dancing and a lesson on how to involve and milk an audience.
This, however, was an ensemble piece and was a huge credit to team work, working with and supporting each other.
Wolds Wonders fully deserve the awards they have won recently and credit must be given to the many volunteers who help them week after week.
If you have a few hours on a Wednesday to come along to Pocklington Arts Centre, I am sure they would be pleased to have your help as they grow in experience and confidence.
Be sure to come to their next production – you will have a thoroughly splendid afternoon.

domain: artistic


The conflict between Russia and Ukraine has been occurring for greater than 8 months. In the meantime, the problem of Pakistan has arisen. A Russian parliamentarian has made a surprising declare about Pakistan. He has instructed that Pakistan is supplying artillery shells to the Ukrainian military. Russian parliamentarian Igor Morozov stated that Ukraine and Pakistan have additionally mentioned nuclear weapons know-how. Igor is a member of the Federation Council of Protection Committee of Russia. Earlier, Pakistan was uncovered when it got here to gentle that it has offered nuclear know-how to international locations like North Korea and Libya.
“Consultants from Ukraine have visited Pakistan and a delegation from Islamabad has additionally visited Ukraine to debate nuclear bomb making methods,” Igor stated. He made this declare in a press convention organized concerning the atomic bomb of Ukraine. Russia’s declare comes at a time when it has intensified arguments for preparations to make use of a grimy bomb on Ukraine. Russia’s state information company Riya Novosti has revealed a report on Igor’s assertion.
Nuclear know-how given to North Korea
Russian lawmaker has claimed that Ukraine’s capacity to make soiled bombs will not be hidden from anybody. Nonetheless, he harassed that the problem of financing is key. He stated through the ongoing dialogue about Ukraine’s Soiled Bomb that the risk to Russia is actual. Igor stated that Ukraine may use Tochka Yu for a low-capacity nuclear assault to make use of its bomb. He additionally stated that the US Parliament has allowed the president to make use of low-capacity nuclear bombs wherever on the earth.
Igor didn’t rule out the likelihood that Ukrainian President Volodymyr Zelensky has mentioned nuclear weapons with allies corresponding to Britain and the US. Nonetheless, the Russian chief has not supplied any proof to assist his declare. Pakistan’s arms firm has equipped arms and ammunition to Ukraine. Pakistan can also be supplying gloves to the Ukrainian military.
If the declare of the Russian chief is true, then this proves that after once more Pakistan’s military is making an attempt to earn cash by promoting nuclear bomb know-how. Earlier, Pakistani scientist AQ Khan had given the know-how of nuclear bomb to North Korea. It’s stated that in return it acquired missile know-how from North Korea.


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CLICK THE PIN TO READ ALL 10 healing mantras and affirmations for reducing stress and anxiety. These positive affirmations help you find peace and joy in life. Check out The Truth Practice to read about inspiration, authenticity, happy living, manifestation, getting rid of fear, intuition, self-love, self-care, words of wisdom, relationships, affirmations, finding passion, positive quotes, life lessons, and mantras.
You cannot pretend to read a book. Your eyes will give you away. So will your breathing. A person entranced by a book simply forgets to breathe. The house can catch alight and a reader deep in a book will not look up until the wallpaper is in flames.

domain: library


A motor yacht with one on board lost all power one mile off the Dart estuary and called the Coastguard for assistance. The Dart D class inshore lifeboat was launched and on reaching the scene discovered that the vessel was 13.6 tonne and 10.6 metres long. The D class put a crewman on board and asked the Coastguard to page the Torbay Severn class lifeboat. The yacht had anchored with 140m of chain and had no power to lift it. The Torbay lifeboat brought the yacht into the harbour towing the anchor and once out of the swell two of the crew joined Chris Rampling on the yacht and raised the anchor chain. The yacht was then towed to her deep water mooring.


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According to the National Consumer Law Center, over half of all accounts in collections are medical debts. Tennessee residents who aren't sure if they owe a medical debt attributed to them should first contact their insurance company to confirm that it is legitimate. If the bill is legitimate, it may be possible to negotiate a lower balance. Individuals can use a medical debt advocate to help with negotiations.
When a person in Tennessee or any other state files for bankruptcy, he or she is usually granted an automatic stay of creditor actions. However, this stay can be violated if a creditor didn't know about the bankruptcy or wasn't aware of the law. In the event that the creditor knew about the bankruptcy, any violation of the stay could be considered willful.
According to one report, 43 million people around the United States who have credit cards believe that having a balance can improve their credit scores. The report details the result of a June 2018 survey that had 1,000 adult respondents.However, according to one senior industry analyst, this is a myth. While how close individuals come to charging up their spending limit is included in the five main benchmarks that create a credit score, having a credit card balance is not.
Many people living in Tennessee and around the country regard debt as a negative thing. However, the reality is that most people at one point or another will go into debt, often for good reasons. Instead of fearing debt, it is often best for people to take a more balanced look at the reasons, both good and bad, for borrowing money or using credit.
Tennessee residents who have medical, credit card or any other type of debt that can be discharged through bankruptcy should file as soon a possible. This is also true for those who have a debt-to-income ratio that is higher than 40 percent. The longer a person waits to file, the less likely it is to get a fresh financial start because of asset depletion. In some cases, individuals don't even buy food to help avoid bankruptcy.
When an individual in Tennessee is struggling to pay his or her debt, it may be possible to file for Chapter 13 bankruptcy. Debts are repaid according to a plan approved by the court, and a plan must be submitted within 15 days of filing for bankruptcy. A judge will make a decision as to whether to confirm the plan within 45 days of a meeting with creditors. Creditors then have 25 days to object to a plan.
When Tennessee residents file for Chapter 13 bankruptcy, they are given either three or five years to complete the repayment program. During this length of time, it is common for someone to need a new vehicle. Fortunately, it is possible to finance a new car while going through bankruptcy. However, the purchase will require approval from the court.
In 2015, Tennessee had the highest rate of bankruptcy filings in the nation; as a matter of fact, the number of filings there was twice the national average. Ergo, the citizens of this fine state are no strangers to the terror that comes with the possibility of not being able to meet their obligations. Moreover, the entire process of filing for bankruptcy can be confusing given the amount of legal red tape surrounding the whole process. For instance, plenty of people are confounded by the difference between Chapter 7 and Chapter 13 bankruptcy.
For many people in Nashville, store-brand credit cards have led to debt that is increasingly difficult to manage. Delinquency rates on these types of cards have reached their highest level in seven years, according to Equifax, the credit reporting agency. The percentage of accounts in default for at least 60 days has risen to 4.65 percent, an increase from 4.08 percent in March 2017. This is the highest level of default on these types of credit card accounts have seen since early 2011.
According to a report from Experian, the average credit card debt in America is $6,354. In Tennessee, the average credit card debt is $5,975. On average, Americans carry 3.1 credit cards to go along with 2.4 retail cards. While many people use credit cards to accumulate rewards points or other perks, it is a good idea to pay the balance off each month. The report found that 43 percent of those who have a balance carry it from one month to the next.

domain: news


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Elton John, Jennifer Lopez and Sugar Ray Leonard are among the celebrities who have donated autographed shoes and photos to help out Hillsides Los Angeles Foster Care Charity during their annual Hillsides Foster Soles online auction. Dr. Drew Pinsky is this year’s Honorary Chair and Celebrity Auctioneer.
The online auction takes place April 25th through May 5th as part of Foster Care Awareness Month. In addition to autographed shoes, the auction will feature purses, belts and other accessories along with set visits and signed scripts.
Hillsides reports other celebrities who have participated in the autographed shoes charity auction include Joel McHale, Jon Cryer, Hilary Swank, Seth Green, Adrian Grenier, Nancy Grace, Wendy Williams, Jane Kaczmarek, Billy Bob Thornton, Tim Allen, Jimmy Kimmel, Anderson Cooper, Piers Morgan, Dave Koz, Charles Barkley, Billy Zane, Mike Epps, Marlee Matlin, Mark Harmon, Edie Falco, and Devon Werkheiser.
For more information, visit www.Hillsides.org.
More on Hillsides:
“As a Pasadena foster care charity founded in 1913, Hillsides creates safe places for vulnerable children and their families by providing residential care, mental health services to break the cycle of domestic violence, special education, and advocacy.”


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The reality behind the Jenner marriage and just how much Kris Jenner knew about her ex-husband's transition desires may never be known.
Whether Caitlyn Jenner ever told her ex about taking hormones remained a she-said, she-said issue when the topic was brought up during the momager's appearance in an upcoming episode of "I am Cait."
"She keeps saying she told me but she didn't," the Kardashian matriarch said while at dinner with her ex and her friends.
"I did too!" the "I am Cait" star interjected.
The pair, who were married for 22 years and split in 2014, have publicly disagreed on the matter.
The former Olympian has stood firm in her claim that Kris knew she took hormones in the 1980s and only halted the transition process for their relationship.
The mom-of-six has a different story.
"What happened was a conversation in a driveway. He says to me, 'Do you ever want to have more kids?' And I said, 'Oh God no.' So he says, 'Oh neither do I, that's great! And I couldn't have any more kids if I wanted to," she recalled, adding the comment confused her.
"He goes, 'Oh geez, you know, back in the '80s I messed around with this or that and it kind of screwed up my sperm count, but whatever," she continued.
Kris chalked up the bizarre explanation to steroids and reminded viewers the couple went on to have Kylie and Kendall Jenner.
"He never said it was estrogen, he never said anything, he just said, 'I took some s--- in the '80s.' There was no, 'I am transgender," she added.
Caitlyn, for her part, refuted the memory and stands by the story she's been telling since her interview with Diane Sawyer.
"I had a condition that I've been dealing with forever, I was on hormones, and that's the reason it might be tough to get pregnant I certainly told her what was going on."
"My version of what happened in the beginning was obviously very different than her version," she concluded.

domain: entertainment


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By Yves Engler
On June 14 defence minister Anita Anand tweeted, “Ukraine is fighting for its territorial integrity, sovereignty — and for democracy itself.”
During a trip to Ukraine a few days earlier finance minister Chrystia Freeland declared, “In fighting for their lives and their sovereignty, the brave people of Ukraine are also fighting Canada’s fight — the fight for democracy.”
Freeland’s rhetoric about democracy began before Russia’s illegal invasion. In November 2019, the same month she backed ousting Bolivia’s elected president, the then foreign affairs minister declared that Ukraine was at the “forefront of the struggle between democracy and authoritarianism” and that “modern Ukraine is the country where the struggle is ongoing and the future of the rules-based international order and genuine democracy in the world will be determined.”
It’s absurd to suggest that the war in Ukraine or Canada’s role in it is about advancing democracy. While efforts to turn Ukraine into an anti-Russian bulwark began before the demise of the Soviet Union, the war in eastern Ukraine started with the U.S.-backed ouster of an elected president.
Despite Canadian election observers endorsing Viktor Yanukovich’s victory in 2010, Ottawa helped overthrow him in 2014. The Harper government immediately sought to destabilize a president opposed to Ukraine joining NATO.
During the Maidan protests, opposition forces – including the far-right C14 – used the Canadian Embassy in Kyiv as a staging ground for more than a week in their successful bid to topple Yanukovich.
The president’s ouster led to a wave of right-wing nationalist violence and political repression. On May 2, 2014, neo-nazi “Right Sector” militants killed over 40 “anti-Maidan” (pro-Yanukovich) demonstrators in a fire at the headquarters of the Odessa Federation of Trade Unions. No one has ever been held accountable for the horrific crime.
In 2015, three Ukrainian communist parties were banned, including one that received over 13 per cent of the vote in the 2012 parliamentary election. Some media outlets were also targeted.
After Yanukovich was ousted, U.S. polling showed that a strong majority of Crimeans wanted to be part of Russia. Polling also demonstrated that people in the Russian-speaking Donbass region wanted greater independence from Kyiv or to join Russia. But Ottawa has been deeply hostile towards the popular will in those regions.
Running on a peace and anti-corruption platform, Volodymyr Zelenskyy crushed hardline nationalist president Petro Poroshenko in the 2019 election. But his early effort to end the fighting in the east was stymied by the far-right and security forces empowered by the U.S. and Canada.
Subsequently, Zelenskyy did a u-turn, pushing ever more repressive policies. With Washington’s backing, he shuttered three television networks in February 2021 that had been sympathetic to his call for peace but criticized his shift in policies. He then imprisoned the leader of his party’s biggest rival.
After Russia’s illegal invasion, Zelenskyy imposed martial law. Basic civil liberties have been suspended and the media is under direct government control. Eleven political parties were suspended, including the largest opposition party.
In Canada and other countries, those pushing to expand Canada and NATO’s role in the fight have sought to suppress debate and civil liberties.
The Ukrainian Canadian Congress has pursued a concerted campaign to shut down speaking events across the country while the Ukrainian Embassy in Vienna recently convinced the city’s trade union council to cancel the room booking for the International Summit for Peace in Ukraine.
A Radio New Zealand reporter was recently dismissed for their “pro-Russia editing” of wire copy while members of the African People’s Socialist Party in the U.S. were indicted as Russian agents two months ago.
In Lithuania, they have disenfranchised Russian speakers while last week Czech President Petr Pavel said Russians in the West should be “monitored” like Japanese during World War II. (During WWII the US interned over 100,000 people of Japanese descent while Canada detained 20,000.)
If you broaden the lens of analysis, the claim that Canada’s motivation in Ukraine is about advancing democracy is even harder to sustain.
In 2019, Freeland supported the ouster of Bolivia’s first Indigenous president. Hours after the military command forced Evo Morales to resign on November 10, Freeland released a celebratory statement declaring, “Canada stands with Bolivia and the democratic will of its people.”
Ottawa provided significant support for the Organization of American States’ effort to discredit Bolivia’s 2019 vote, which fueled opposition protests and justified the coup.
“Canada commends the invaluable work of the OAS audit mission in ensuring a fair and transparent process, which we supported financially and through our expertise,” noted Freeland at the time.
But the OAS audit mission was designed to precipitate Morales’ ouster. A slew of studies demonstrated the partisan nature of the OAS audit mission, and a year later, Morales’ former finance minister, Luis Acre, won 55 per cent of the vote for president and his MAS party took a large majority in the Congress.
In December, the Trudeau government backed the ouster of elected leftist Peruvian president Pedro Castillo. Canadian officials immediately justified Castillo’s removal and Canada’s Ambassador to Peru, Louis Marcotte, worked hard to shore up support for Dina Boluarte’s replacement “usurper” government.
As Owen Schalk and I demonstrate in the forthcoming Canada vs. Democracy: A History of Canadian-Backed Coups, Ottawa has actively or passively backed the removal of more than 20 elected governments. Our main ally in Ukraine, the U.S., has been involved in many more coups.
One has to be extremely naïve to think Canada’s engagement in Ukraine is about democracy.

domain: politics


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We have not raised our prices on cardboard storage boxes for several years but the latest shipment of card storage boxes has increased in price as has most cardboard and plastic. The price on the card storage boxes has increased by 50 cents on the single long box and by $1 on the shoebox and larger boxes.
Tuesday, April 13, 2021
Monday, April 12, 2021
Sunday, April 11, 2021
Saturday, April 10, 2021
Here is the latest from WOTC regarding in store play. Basically, stores in North America currently cannot run sanctioned in-store events. We cannot report any sanctioned events to WOTC and cannot run an in-store pre-release tournament, even unsanctioned. Unsanctioned pre-release events are banned because pre-release materials can only be used at official pre-release events and the only official pre-release event is the Strixhaven Pre-release at home. Ergo, you can get the pre-release kit and run an even at home, but not here.
Thursday, April 8, 2021
Wednesday, April 7, 2021
We never brought in any of the Funko boardgames, since the POP figures included with the games are not full size figures. However, if you are a POP collector and are looking for some of the small POP figures, or just want to try out the game, we have sever in the used game section now: Batman, Harry Potter, Rick and Morty and The Golden Girls. I would love to see the Golden Girls go up against a few of Batman's villains.
Tuesday, April 6, 2021
For some reason, WOTC has under produced Strixhaven Draft boosters and we have gotten severely allocated on them. Currently, it looks as if we will receive one case upon release. Plenty of Set and Collector boosters, of course, but draft boosters will be highly limited.


Krysti Worley - Hollowell is the youngest of four girls. Although born in Georgia, Krysti moved to Texas at the young age of three. Krysti has been performing on stage, with her older sisters, from the ripe age of two. Krysti's older siblings were Georgia state champion cloggers’ and were the opening act for great talents such as Jerry Reid, Hank Williams Jr., and The Oak Ridge Brothers. Even though Krysti started performing at such a young age, it wasn't until the age of fifteen that her family realized that Krysti had a voice. Krysti, being raised in a Christian home, she attended private school. It was at school that the music teacher realized her talent. Krysti's teacher asked if she would compete in State competition for solo performance...she did and placed third! Krysti has always had a love for music, and that is why she decided to pursue a career in music. She started writing music and attended an Austin songwriting seminar, where she met frontman Ray Benson of Asleep at the Wheel. Ray took Krysti under his wing and recorded her in his studio at age 16. Krysti was up against Jessica Andrews for a record deal with DreamWorks records in 1996. Jessica ultimately got the deal. When she was Eighteen, she signed an Artist/Management contract. Krysti spent the next few years in the studio, in Nashville, recording her first single "Cry Like A Baby". Krysti's first single charted in the top 10 on the Texas Music Charts. She toured around the United States promoting her single, doing radio interviews and shows. Krysti took a bit of a break from music when her father was ill. She then took an even longer break from music to start an even bigger journey as a mother! While Krysti loved being a mother, she could not deny her love of music! Krysti knew she could do both! However, this time she decided to do things on her own. Krysti had already been down the road of recording and promoting song singles and knew that she could do it! So, Krysti started writing (again, after a long time) and picked a great recording studio not too far from home to record her EP. Krysti then started contacting radio stations and promoting her first very own cd. This gave her much Joy! Krysti realized she loved developing and producing as well as performing
Although Krysti has in the past been mostly country, Krysti has ventured out of the country box in the past few years and performs a wide array of music from disco/dance, contemporary, country, Christian, and rock music! Krysti says, "I don't discriminate"!
Krysti has written songs and promoted other country and indie artists with her husband Jay. It brings great joy to Krysti to make music a part of her family life as well!
Currently, she is performing as lead vocalist in a band, Boogie Town. Krysti has said, that even though there is something amazing about performing live with a full band, she admits that at the same time, she absolutely loves the creative freedom that comes from playing more intimate shows, with just a guitar and her voice, Krysti and Kevin, the acoustic duo. Krysti does have a love that runs deep for music, but her greatest love of all is when she volunteers to sing at the church she and her family attend. Paulann Baptist Church.
So, Krysti is living her dream, all of them with her supportive husband, wonderful boys, (three of them), and her music!


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However, he we want to consider The Duchess of Malfi as a Revenge Tragedy, we need to know what we mean by revenge tragedy and its major conventions. Duchess of Malfi Answer: The revenge play or revenge tragedy is a tragedy in which a murder victim is avenged, often by a younger kinsmen. ‘DUCHESS OF MALFI’ AS A REVENGE TRAGEDY | The main aim of this work is to point out series of revenge that occurs in the text and find.
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However, The Duchess of Malfi contains full of such terrifying, hair-raising situations from the beginning to the end. In this play we see madness of these mad people.
There should obviously be a desire for revenge. Horrors in The Duchess of Malfi: The last two acts of the play have an abundance of them. In particular, a third scene is very significant because the premises for the plot’s development are set in it. The sorrowful answers which the echo makes to Antonio’s words are the result of a natural phenomenon. For example, in 5. The plot should involve physical horrors, such as poisoning and torture. However, hue is some psychological interest too present in it.
The tgagedy hero is a descendant of earlier comedic male characters who were rogues, but he is a sign of the times in that during this period he supplanted the traditional romantic hero in many of the age’s theatrical productions. Enter the email address you signed up with and we’ll email you a reset link.
This is probably because his goal is to have sex rather than to cuckold.
DUCHESS OF MALFI AS A FINE TRAGEDY | Ali Assi –
Revenge tragedy, a kind of tragedy popular in England from the s to the s. Taking their cue from the activities and ideas that prevailed in the Restoration Court, the Restoration playwrights fashioned a character type who could be successful in an uncertain society by outwitting others without being hampered by an outmoded morality.
However, the Latin playwright, Seneca, is considered to be one who established the revenge play tradition. She also wins the battle of the sexes, played out in the arena of wit in which his aim is seduction and hers is matrimony.
“The Duchess of Malfi” as a Jacobean Revenge Tragedy
The last horror comes when Julia is poisoned in a most cold-blooded manner. The character of the rake-hero is a product of Restoration society.
Duchess of Malfi ;is it a melodrama raise to the level of a tragedy? A ‘typical’ Jacobean revenge tragedy contains conventions: She resourcefully pursues Wilmore and wins him. Helena aspires to the control of the situations in displaying an equal ability to revene other characters and determine plot as when she disguises herself as a boy and disrupts the relationship between Angelica and Tragrdy. Bosola confesses that he sees an image of the Duchess.
It can be seen that how he works for ferdinand and cardinal and acts as a spy to the duchess but fails to get the wishful rewards. In the act where the Duchess, her children, and her maid are executed many devices are used by the author for the aim of creating cuchess which is a common taint of Senecan revenge tragedy.
Log In Sign Up. He doesn’t present and of the conventional hosts and objectives portents found in typical revenge plays.
We have seen that there was a love affair between the Duchess and Antonio and at last they marry and they produce three children. By doing modification, he is able to make the play more reasonable to the audience. Still, just be careful when you make bold statements. Wit is also a comic and clever way to woo a member of the opposite sex. Witty repartee is often operative in these plays, used as a x to ridicule and reveal the flaws of others as well as an aid in attaining one’s own goals.
Duchesd narrative should incorporate ghosts, skulls and madness. Another aspect of a revenge tragedy is that the persons malfl in the revenge ultimately feels remorse for what they have done and in most cases it leads to their damnation.
The name Revenge Tragedy arose from the Senecan tradition of making revenge the motive force for the action that leads to the tragedy. Also, the marriage of revegne high born lady is supposed to be subject to political arrangement but trayedy to personal whim. The characteristics of Revenge Tragedy are: Wilmore, the rake-hero of The Roverexemplifies many of these traits, but he differs in significant ways. The spectacle of waxen images of the dead bodies of Antonio and children presented before the Duchess is another horrid scene.
There should be Italianate or Southern European settings. Order should be restored at the end of the play. Bosola then attacks reevenge Cardinal, but is himself attacked by Ferdinand. The revenge tragedy genre of English literature generally refers to a body of dramatic works written from the mid- s to the early s, from the Elizabethan to the Caroline period.
By Ogbuanya Chinyere Judith. Horrors and violence predominated in the Senecan tragedies.


Under the terms of the development agreement, Ballard will develop a 200kW fuel cell engine for the Mireo, with the first main line trials planned for 2021.
The deal is worth around $US 9m to Ballard.
“Our cooperation with Ballard is a decisive step towards replacing diesel-powered rail vehicles with emissions-free vehicles in the long-term interests of sustainable and climate-friendly mobility,” says Siemens Mobility CEO Mrs Sabrina Soussan.
Ballard is also working with CRRC Tangshan on a hydrogen-powered LRV. Trials began on a 14km light rail line in Tangshan last month.


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06.07 - 01.08.2008
First personal exhibition of Ievgen Petrov is a summer erotic horror about water and rapacity; a remix of movie "Jaws", which could be filmed by Quentin Tarantino and David Lynch.
"Once, I was sinking,-tells Petrov. - It is very interesting under the water, when you sink. In the beginning you feel fear, then panic, and after all- resignation and indifference. Finally, you just start examine the wet surrounding. In "Aqua Park", I have tried to reproduce this gradual penetration into depth. It's great, that uncle Lyonia saved me...Those, who had sunk, do not write paintings."
"Aqua Park" is not the whole story, but a constellation of narratives, which are combined with one water-space theme. Notable, that this summer vacation does not seem careless. Sharks eat naked chicks, and horny men bare their teeth and cut fish.
"Water changes people. At the sea, males turn into predators, filled with beer, and females and fish - into catch of males- hunters. When people enter the sea, they urinate at first. This is the time when water and man unite. Individual leaves its sign and starts living water rules."
Petrov subtly feels history's nerve, her key mood. Canvases are full with contrasts: black humor adjoins with touching romantics, death with entertainment and sex. Everywhere are drama and tension. Here you can smoke cigarette, while the boat is blowing up after your back; you can jump inside the rubber poll, while the plane is flying towards the twin towers. Dogs and piglets run on the ocean floor, the man looks sadly inside the jar with fish, and people on the shore teem inside the giant whale, as if they were parasites.
Moreover, the technical side of the project deserves separate attention. Petrov is well known by his maniac scrupulousness of artistic practices, which is hardly peculiar to modern careless artists.
"I have tried to draw water with oil, but realized, that water theme should be performed with watercolors. To tell you the truth, water is hard to draw, especially, colors. For example, color of human skin under water seems dirty, like the one drowned man has. The only medium with over-water environment are sun glints. The place they fall has skin color, everything else -a color of a dead flesh. It is hard to reproduce. I had to throw out at least eight paintings, until I got what I have wanted. "
Petrov's debut is the event for Kiev art-scene, because new worthwhile names rise up here rarely. Anyways, "Aqua Park" is a project everybody should see, before going on vacation.


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A dog seizure can come at any time and when it does the effects are scary to watch and damaging to the dog. Many dog owners unfortunately will experience this episode in their dog at some point in the lifespan of their pet. Dog Seizures do have warning signs and sometimes can be predicted, so there are symptoms to look out for. A seizure is a sudden reaction from the brain that causes involuntary movements. This may include weakness, numbness, twitching, and possible paralysis. There are two forms one more minor, "Petit mal" and major "Grand mal". Dog seizures are linked to epilepsy but can manifest from other areas as well.
Treatment of Dog Seizures is very easy with the help of some specific medicines. Though these types of treatments are effective, still there are some side effects of such treatments, so to prevent your pet from such kind of side effects of pharmaceutical medicine there is another way of treatment you can opt and that is natural treatment. Natural ways of treating seizures in dogs are very easy and you can do them at your place. We will see how dog seizure treatments can be managed with diet and proper supplements.
Natural Diet and Supplements Help Seizures in Dogs
Diet is very important to your dog. An unhealthy one starts the process for poor health. Foods that are full on unnatural products such as filler, by products, processed ingredients, colors, etc can be a contributing factor to seizures in dogs. Instead opt for the diet or foods that are more natural or home made. There are more brands now available with a more natural recipe for dogs and you can check with your vet for suggestions.
Vitamins and supplements
The importance of the immune system having the best chance at health and its wellness is also important in combating seizures in dogs. There is so much at comes in contact internally and externally with a dog that vitamins and supplements are the best and most natural way to protect a dog's immune system. Vitamins and supplements working together are a great benefit against dog seizures or any other health concerns. Vitamin C, E and B6 are good for dog and helps in avoiding seizures in dogs. Start with 500mg of vitamin C two times per day, 400mg of E and 50mg of B6 for a 50-lb. half the dosage if dog weighs 25 pounds. Vitamin C is great for immune system maintenance. It is known as having the least toxicity when it comes to vitamins.
Regular exams and visits to the veterinarian are necessary for a dog's health. This advocate for dogs is also a good source of information on the best ways to make your dog's life as optimal as possible and preventing seizures in dogs. They have great advice as to natural ways to keep your dog happy and health with the least risk to them.
Some triggers to avoid around your dog:
Toxic flea products
Cheap painted toys
Get your dog lots of time outside or recreationally. The more exercise the better as it helps with muscle function, development and all around health. A body that is in good condition will help with digestion and perform better. It is one of the most beneficial and proactive way to avoid dog seizures.

domain: pet


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I said I would give pink a rest...but sorry. It is literally all I am going to wear this season. And when it snows (which apparently will happen this Friday) get ready for me to give you all the winter wonderland goodness against soft pink. Yep...I still shoot outside when it snows. See how much I love making content for you guys????
But back to this look...I absolutely love love love this coat. It is so chic and has amazing personality. I tried it against different colors but for me, the true beauty comes out when I pair it with White. So, if you are one of those people who actually follow fashion rules...then this may not be the post for you.
Have a look at way too many pictures of this coat...and snag it for 40% at the links below.


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This post may contain affiliate links. Please read my disclosure policy.
Creamy Cole Slaw
- 1 medium head of cabbage, shredded
- 3 teaspoons salt
- 1/2 cup shredded carrots
- 1 tablespoon shredded sweet onion
- 1/2 cup granulated sugar
- 1/2 cup white vinegar
- 2 cups mayonnaise
- 1/2 teaspoon freshly ground black pepper
- dash celery seed
- Shred the cabbage, chopping any remaining pieces or large leaves. Mix the cabbage with the salt and place in a colander set over a large bowl. Cover the cabbage with plastic wrap and place a couple of heavy salad plates on top. Put the bowl and cabbage in the refrigerator and allow it to sit for at least 1 hour and up to 4 hours to drain the excess water. Pat the cabbage dry using paper towels.
- In a small bowl combine the remaining ingredients from the carrots through the celery seed. Whisk until blended. Place the cabbage in a large bowl and fold in the mayonnaise mixture until blended. Refrigerate for several hours or overnight. Check seasoning and add salt and pepper if needed. Serve and enjoy!


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An unusual place. A bridge that goes from nowhere to nowhere. From a distance it seems that the bridge stands in the middle of the field, but coming closer you can see that a stream is flowing.
In fact, the span of the bridge, 55 meters long, was built in 1940. It had to become part of the new railway line under construction between the city of Tukums and Kuldiga.
Soon the Second World War began, since Latvia was also in a state of war, the construction was not completed.
Now there is a bridge span from nowhere to nowhere.


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Your doctors and staff at River Valley Dental (www.pioneervalleyhybridge.com) are proud to be a provider of Hybridge®, an ideal permanent dental implant solution for single tooth replacement, multiple tooth replacement, or full mouth restoration. By attaching permanently to the implant supports instead of the gums or natural teeth, Hybridge eliminates the many problems associated with conventional treatments. During the treatment process, patients receive temporary, comfortable tooth replacements to ensure that they never have to go without teeth.
Hybridge looks, feels, and functions like your natural teeth. If you have compromised, damaged, or missing teeth, it’s easy to get caught in the endless cycle of time-intensive and expensive crowns, bridgework, and dentures that only provide a temporary solution to your problem. Choosing Hybridge will end this cycle, permanently.
Dr. Gojgini is specially-trained to provide this state-of-the-art, permanent implant treatment at River Valley Dental’s two convenient Pioneer Valley office locations in Hadley, MA and South Hadley, MA.
“Because of poor dental health, I had to have all of my teeth replaced, but if you only need one or two, Hybridge is also your solution. Having something permanent is important to me. That’s why I chose Hybridge.”
– Scott, actual Hybridge patient
“I didn’t want to wear dentures, so my dentist referred me to Hybridge. Once I found out they’re permanent, I knew they were the solution for me. Best of all, I don’t have to cover my mouth anymore.”
– Colleen, actual Hybridge patient
To learn more, visit our website at PioneerValleyHybridge.com or contact us by phone (1-413-800-2205) or email to discuss treatment options and schedule a consultation. There is also a convenient contact form here. We’ll be happy to analyze your unique situation and recommend the best treatment plan for you.
Click the links below to watch videos about the various types of treatment:
Above text content courtesy of www.hybridgeimplants.com.

domain: medical


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‘The U.S. housing market is crumbling under the weight of higher mortgage rates and rock-bottom affordability’: Prices fell the most in these U.S. states
Americans are finding it hard to afford homes at mortgage levels now beyond 7%, according to some measures. Home prices have begun to reflect that.
As mortgage rates rose in the last quarter of 2022, Americans found the cost of homeownership increasingly challenging, adding hundreds of dollars in interest to their potential monthly mortgage payment. Yet home prices held steady, given how few homes were on the market.
But months of high mortgage rates and a drop in home sales are finally impacting home prices. Single-family home prices slid 1% in January, as compared to December 2022, according to data from Moody’s Analytics.
“The U.S. housing market is crumbling under the weight of higher mortgage rates and rock-bottom affordability,” Matthew Walsh, Moody’s Analytics housing economist, said.
Alaska had the biggest decline in month-over-month prices. Home prices fell by 4.9% in January. New Mexico and Wyoming followed, with a 3.8% decline. Mississippi took the next spot with home prices dropping 3.7% in January as compared to the month before.
However, it wasn’t all bad news. House prices also rose month-over-month in Indiana, by 2.2%, West Virginia, by 1.1% and Vermont by 1%.
But looking at prices year-over-year, the West Coast is leading the drop, Moody’s Analytics said, with California, Nevada and Washington reporting values below what they saw in 2022.
The median price of an existing home was $359,000 in January, according to the National Association of Realtors. The median price of a new home sold in January was $427,500, according to Census data.
To be clear, home prices aren’t crashing, but rather falling gradually as buyer demand dries up.
Part of the reason why sales aren’t moving more is because sellers are reluctant to list. Having secured an ultra-low mortgage rate over the last two years, there’s little interest in giving up that deal.
“There were fewer new listings in January than at any point on record, with the exception of the start of the pandemic,” Taylor Marr, deputy chief economist at Redfin, said in a recent report.
“That hampered demand because it meant that many of the buyers who were still in the market had a tough time finding a home that met their needs. The shortage of homes for sale also buoyed home prices,” he added.
Home purchase applications have dropped to the lowest level in 28 years, the Mortgage Bankers Association said this week.
“Following two years of double-digit price growth, the housing market is extremely overvalued, and affordability is near a three-decade low,” Walsh wrote in a note.
“The housing market will descend further into correction through 2023. Our baseline forecast expects that house prices will decline by 5% to 10% over the
next two years,” he added.
He expected home prices to go back to 2021 levels by 2025.
For more updates check below links and stay updated with News AKMI.
Life and Style || Lifetime Fitness || Automotive News || Tech News || Giant Bikes || Cool Cars || Food and Drinks


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The Royal Thai Police yesterday (Dec 4) unveiled the record seizure of drugs in the capital with 12 million methamphetamine pills and 12 kilograms of “Ice” or crystal methamphetamine.
Royal Thai Police commissioner Pol Gen Chakthip Chaijinda said the seizure followed the arrest of Pongsakorn Phaworn, a drug suspect, in Samut Prakan’s Bang Phli district earlier this month.
Mr Pongsakorn was arrested while in possession of 10.3 million methamphetamine pills. The suspect allegedly named two more persons in his network–Sarawut Nuern-Phu and Alongkorn Yongprayutalong.
Both men were later kept under surveillance which led to the information that a major consignment of meth pills was being brought into Bangkok from the northern part of Thailand.
Mr Sarawut was responsible for driving the pickup truck with the drugs into Bangkok and leave the vehicle in Soi Phraya Suren 19 in Bang Chan district. Then Mr Alongkorn would come to drive the pickup truck out of the Soi.
As Mr Alongkorn got in the vehicle, plainclothes police officers showed up and apprehended both of them.
The search of the vehicle found drugs wrapped in plastic packages which were concealed among orange packs.
The arrest of the two led to a raid on a rented house in Klong Sam Wa district where 12kg of Ice was confiscated. The house had apparently been used as a holding point to distribute the drugs in Bangkok.
Police were going after 3-4 suspects in the drug network, Pol Gen Chakthip said, adding that this is the largest drug haul being seized in the capital in many years.


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As vice president of education and visitor engagement at the Rock & Roll Hall of Fame in Cleveland, Jason Hanley often observes the museum’s visitors.
“I constantly see parents and children talking and sharing stories about their favorite musician or song,” says Hanley. “People dance and even cry in the exhibit halls. It’s incredible to see how rock music has played a role in everyone’s life.”
Indeed, since the 1950s, when Bill Haley and His Comets released “Rock Around the Clock” and Elvis Presley’s rendition of “That’s All Right” drove rock ’n’ roll to the top of the pop charts, the genre has become America’s soundtrack. Rock ’n’ roll is the music that your parents played on transistor radios, that animated your proms and road trips, and that electrified your first romance.
Such is its indelible impact on everyday life that in the last 25 years, nearly 12 million people have visited the Rock & Roll Hall of Fame.
The Rock Hall was the first museum dedicated to rock ’n’ roll, and its opening on Sept. 2, 1995, in a glistening I.M. Pei-designed building along Lake Erie, was a landmark event for popular culture. “It was truly significant,” says Hanley, “because rock music was being recognized, preserved, taught, and honored in a way traditionally reserved for high art forms.” Rock ’n’ roll’s royalty — think James Brown, Bob Dylan, and Aretha Franklin — showed up and celebrated with epic performances in Cleveland’s old Municipal Stadium. “We occasionally show that concert in the Rock Hall’s theater. It had so many special onstage collaborations, like Bruce Springsteen and the E Street Band backing Jerry Lee Lewis on ‘Great Balls of Fire,’ ” says Hanley.
In the 1980s, the Rock & Roll Hall of Fame Foundation chose Cleveland for the Rock Hall over New York, Memphis, Philadelphia, and New Orleans because its rock music roots run deep and strong. Cleveland disc jockey Alan Freed popularized the term “rock ’n’ roll” and organized the first rock ’n’ roll concert — The Moondog Coronation Ball — in 1952. Touting its reputation as a breakout city for artists from Buddy Holly to David Bowie, Cleveland campaigned hard to land the Rock Hall by raising $65 million and flooding a nationwide poll with hometown votes.
Cleveland’s persistence paid off. The Rock Hall’s rollout was a turning point for the city and its image — the downbeat that shifted the lakefront from industry to culture and recreation, bolstering the area economy to the tune of $2 billion since 1995. “People around the world make the pilgrimage to visit the Rock & Roll Hall of Fame on the beautiful shores of Lake Erie,” says Hanley. “It’s a great symbol that identifies this city.”
The Rock Hall’s exhibits take visitors on an incomparable — and often interactive — journey that extends from rock ’n’ roll’s roots in blues, gospel, rhythm and blues, country, folk, and bluegrass to contemporary groups like the Lumineers and Arctic Monkeys. “Anything we have on display has to be an authentic artifact that tells part of the story of rock music,” notes Hanley. Visitors get to see guitars owned by Muddy Waters and Eddie Van Halen, outfits worn by the Beach Boys, the Mellotron that the Beatles used for the singular sounds of “Strawberry Fields Forever,” a replica of Pink Floyd’s set from The Wall tour, and handwritten lyrics — including Billy Joel’s “My Life” and Jimi Hendrix’s “Purple Haze” — complete with cross-outs and changes that convey the artistic process.
Enhancing those treasures are unique experiences such as watching musicians tell stories about recording sessions or relishing powerful songs and performances that prove rock ’n’ roll is here to stay. “People sometimes think they can blow through the Rock Hall in an hour or two,” says Hanley, “but even if they just watch artists’ videos and listen to music, they easily could spend two days.”
25th anniversary high notes
Because of the COVID-19 virus, the Class of 2020 Induction Ceremony was rescheduled to Nov. 7 in Cleveland’s Public Auditorium, and for the first time, the event will be broadcast live on HBO. Inductees include Depeche Mode, the Doobie Brothers, Whitney Houston, Nine Inch Nails, the Notorious B.I.G., and T. Rex. The museum is displaying a Class of 2020 exhibit and presenting a virtual exhibit featuring images by veteran induction ceremony photographer Kevin Mazur. Arrangements also are underway for a special 25th anniversary concert. Details — and headliners — are pending, so stay tuned.


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Amplify Theatre, a new amateur theatre company in Norwich, aims to say something about the world we live in, to create theatre that questions the taboos in society and why they are there, and to shine a light on issues pushed to the side, forgotten or even actively avoided.
Using theatre to battle through a haze of British awkwardness and emerge with unashamed expression, the company hopes to start up important discussions in the local community.
Their upcoming double bill production, raising awareness of male suicide features the plays 'Breathing Corpses' and 'Tommy'. Performed at Norwich Theatre Royal's Stage Two, this stigma breaking production is sure to be an evening of moving theatre.
Book now to avoid disappointment.
1st and 2nd March, £10 full price, £6.50 student.
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Meet Adoptable RAZZ! Everyone that meets Razz says What a wonderful boy!, He is such a good dog! AND HE IS. Razz lived in a home with a 11 yr old blind child & his 9 yr old sister. He loved his kids & misses his kids!
Sadly, his home life changed & due to NO fault of his own, he was surrendered to the rescue. The perfect home for Razz would be one with Kids (recommend age 5 or older), someone that likes to play fetch & a family that is not away from home a lot. Razz would also love to have a companion dog to be his buddy.
Razz is estimated to be about 7-10 yrs old, weighs 63 lbs, is neutered, vaccinated, Heartworm negative, crate & house trained. Razzs breed mix description is a guess according to his appearance. If you are interested in Razz, please email us at email@example.com. We offer a 2 week trial period with all our dogs to make sure they are a good fit in their new home. You must be at least age 25 yrs old to adopt for our rescue.
FindpetTM is a Participating Pet Recovery Service Registry for the AAHA Universal Pet Microchip Lookup Tool. AAHA provides an
internet-based application that enables veterinarians, humane organizations, pet owners or other persons to search various Pet
Recovery Service registries and identify those registries on which a particular microchip is registered. AAHA is not affiliated or
involved with any specific microchip registry and has no relationship, financial or otherwise, with this Participating Pet Recovery
Service Registry ("Registry"). This Registry has given AAHA permission to search the Registry's database in order to assist pet
owners in being reunited with their pets. AAHA does not maintain a database of microchips of its own. It only links to registries such
as this one. The AAHA Universal Microchip Lookup Tool only searches the databases of companies that elect to participate in the


This Is Simple HVAC Advice Not Found Elsewhere Online
An HVAC system failure is probably the most frustrating occurrences a property owner can face, largely mainly because they might not are aware of the right person to call. However, by simply spending some time learning about what to look for inside a contractor, things can actually go rather smoothly. Read more to get some helpful insights.
When buying a whole new HVAC system for your house, make sure it can be energy efficient. Today, most new HVAC systems are energy efficient you will find a energy star label around the equipment. However, to make sure your utility costs usually do not check out the roof, choose equipment that may be cost effective.
Prior to deciding to hire someone to do any focus on your HVAC, make sure you get yourself a written estimate which contains itemized costs listed on it. This will guarantee that comparing one contractor to a different one will probably be simple as we discussed what one offers that another doesn’t, or what price they’re charging for the very same items.
Be sure to ask for an estimate in writing before selecting a particular HVAC vendor. There are a lot of moving pieces when it comes to purchasing these big items. You’ll want to compare not just the expense of the gear, but the create and also the overall energy costs.
Cover your unit when you are mowing the lawn. Aim the grass in a different direction from the unit. This same tip applies if you are blowing fallen leaves across the yard. Grass and leaves pose a serious problem for that internal functioning of your own unit.
Your HVAC unit requires regular maintenance no less than two times per every year. The spring and autumn times are the most useful time to get it checked. Even if you can’t see anything wrong, checking it may well enable you to locate and repair some possible issues.
Should your evaporator coil, found inside your home, becomes dirty, your unit will lose efficiency. Just pop away from the front panel in the furnace and verify that the coil is dry. Utilizing a brush attachment over a vacuum, gently clean the coil associated with a dust or any other debris.
Sometimes, it can be hard to find out should your HVAC system has to be fixed or should be replaced. Should your system frequently fails, is always switching on or off alone, or if your debts are way too high, it might pay to have it replaced. Otherwise, little things can you need to be fixed.
Clean your filters! If you have a window unit air conditioner, you will see a filter right underneath the grill it is possible to vacuum. When you have a furnace or outdoor units, they will also have filters to be cleaned or replace. A dirty filter can certainly make your unit inefficient as well as permit it to overheat.
It can be challenging to deny the point that a failed HVAC system can wreak havoc within the lifetime of any homeowner, particularly during periods of extreme weather. Fortunately, you can find things which can be done to mitigate the frustration experienced during such events. Utilizing the advice presented above is a great way to stay prepared.Now that you’re an HVAC novice, get more pro advice from the residential refrigeration expert technicians at DK Air Conditioning, Heating & Refrigeration. This article is copyright protected.


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Use this link to login to Hashkings
Understanding the farming cycle of Non-fungible (NFT) and Fungible Tokens, a fully tokenized blockchain experience, will help you discover your perfect role within the Hashkings ecosystem.
The farming cycle begins with friend Shaggi, an avatar (NFT) that the user controls. The user will control Shaggi who utilizes a land plot (NFT) to plant a seed (NFT) and adds the required amount of HKWATER (fungible token) earned daily from owning a water tower (NFT). After waiting the specified the number of days unique to each land plot and seed the user has the ability to harvest BUDS (fungible token).
Let's take a look at the in-game NFTs below:
Below are the fungible tokens:
Your Hashkings experience begins with an avatar, an advanced NFT that saves experience points and contains other user profile data. Once you own an avatar, you will need a land plot and a seed of the same region, add HKWATER, which is produced by water towers and wait to harvest your BUDS. Please note that seeds are burned (destroyed) once the plot is harvested.
BUDS are a versatile and liquid token in Hashkings which can be used in various scenarios:
Burn them to get MOTA
Roll joints to get experience points for your avatar
Trading on HIVE ENGINE
If you choose to burn BUDS in order to receive MOTA you get the opportunity to stake them and become part of the big drop event where you will receive SEEDS. Seeds can either be sold to other players or used on your own farm.

domain: agronomy


SERS nanosensors and nanoreporters: golden opportunities in biomedical applications.
This article provides an overview of recent developments and applications of surface-enhanced Raman scattering (SERS) nanosensors and nanoreporters in our laboratory for use in biochemical monitoring, medical diagnostics, and therapy. The design and fabrication of different types of plasmonics-active nanostructures are discussed. The SERS nanosensors can be used in various applications including pH sensing, protein detection, and gene diagnostics. For DNA detection the 'Molecular Sentinel' nanoprobe can be used as a homogenous bioassay in solution or on a chip platform. Gold nanostars provide an excellent multi-modality theranostic platform, combining Raman and SERS with two-photon luminescence (TPL) imaging as well as photodynamic therapy (PDT), and photothermal therapy (PTT). Plasmonics-enhanced and optically modulated delivery of nanostars into brain tumor in live animals was demonstrated; photothermal treatment of tumor vasculature may induce inflammasome activation, thus increasing the permeability of the blood brain-tumor barrier. The imaging method using TPL of gold nanostars provides an unprecedented spatial selectivity for enhanced targeted nanostar delivery to cortical tumor tissue. A quintuple-modality nanoreporter based on gold nanostars for SERS, TPL, magnetic resonance imaging (MRI), computed tomography (CT), and PTT has recently been developed. The possibility of combining spectral selectivity and high sensitivity of the SERS process with the inherent molecular specificity of bioreceptor-based nanoprobes provides a unique multiplex and selective diagnostic modality. Several examples of optical detection using SERS in combination with other detection and treatment modalities are discussed to illustrate the usefulness and potential of SERS nanosensors and nanoreporters for medical applications.
Vo-Dinh, T; Liu, Y; Fales, AM; Ngo, H; Wang, H-N; Register, JK; Yuan, H; Norton, SJ; Griffin, GD
Volume / Issue
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I have a S&W model 28-2 .357 mag 4" Hwy Patrol revolver in good condition for sale. Shows some wear on the cylinder and barrel. Blue condition is still about 80% with some small nicks as well. Action is smooth and cylinder locks up tight. No box or paperwork.


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Follow live coverage of the third day of the first Test between England and Pakistan from Lord's. JAMES DUTTON will bring you all of the action as it happens in our over-by-over live blog.
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Catch all the live action from the 1st Test between England and Pakistan at Lords through our live commentary
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Pakistani cricketer Hussain Talat (C) celebrates the dismissal of West Indies batsman Samuel Badree (L) during the first T20 match between Pakistan and West Indies at National Stadium in Karachi on Ap
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Membership comprises parliamentarians from the Lords and Commons and associate members from business, education and all other organisations and institutions involved in engineering, with a particular emphasis on young engineers attending and becoming involved in events.
Three formal events at Westminster take place every year (see calendar page) and additional activities may be inserted into the parliamentary programme, in conjunction with associate members of the Group.
Speakers to date have been:
An annual review will be produced each year and sent to all members and associates and relevant organisations.
The All Party Parliamentary Engineering Group intends to be an innovative parliamentary group enabling contact and involvement from the highest levels of government with the engineering profession but with a special emphasis on young engineers.