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These projects have been financed within the framework of the State Programme for the Promotion of Scientific Research by:
HYDRA will focus on how river functioning and service provisioning are affected by hydrological alteration (HA) from dam operation and land use changes. These two factors are nowadays the main sources of hydrological alteration worldwide, and they have serious consequences on biodiversity and on the provisioning of ecosystem services generated within the river system.
Floods are the most damaging natural catastrophe in Spain. Risk assesment for coastal and river floods require the compilation of event information in order to systematically analyse the trends and impacts produced.
The risk of flooding and erosion is increasing for many coastal areas owing to global and regional changes in climate conditions together with increasing exposure and vulnerability. Conventional coastal engineering solutions based on hard structures are increasingly challenged by the new situation and their rising maintenance costs may become unsustainable under certain projected futures.
The general aim of TRL+ is supporting offshore system developers in the pathway from a concept to the market, through all the technology readiness levels (TRL). The main objective of TRL+ is to create innovative and highly competitive services to boost the offshore energy sector to the future market, supporting developers and side industry involved during the whole life cycle of an offshore farm.
The DOVICAIM project aims to develop an integrated methodology and the necessary tools to support the entire life cycle of the construction of vertical docks using prefabricated caissons in floating caissons, including design, optimization, construction, installation and operation.
This project aims to support the planning of adaptation strategies for ports to climate change through the development of methodologies that allow the estimation of the impacts of climate change at high resolution in the different areas of the port.

domain: geography


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When it comes to goats, many old wives’ tales and myths are floating around. One of the most common questions we get is whether or not goats can eat rosemary.
Can goats eat rosemary? People always seem surprised when we tell them that goats can eat rosemary! Rosemary is a very healthy treat for goats. Not only does it taste good, but rosemary also has a lot of health benefits for goats.
This article will go over some of the benefits of feeding rosemary to goats and how to incorporate rosemary into your goat’s diet. Keep reading to learn more about why you should be feeding your goats’ rosemary.
What is rosemary?
Rosemary is a member of the mint family, and it is related to other herbs like basil, oregano, and thyme. Rosemary is native to the Mediterranean region, but it is grown all over the world these days.
Rosemary is a perennial plant, which means that it will come back year after year once it is established. Rosemary plants can grow quite large, up to six feet tall in some cases.
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The benefits of rosemary for goats
Rosemary is often used as a decoration or as a culinary herb. But did you know that rosemary also has a lot of health benefits?
Helps with digestion
For goats, rosemary can help digestion and act as an appetite stimulant.
If your goat has trouble with its appetite, try feeding it some rosemary. The herb can also help to settle an upset stomach.
A source of important nutrients
Rosemary is a good source of several important nutrients, including calcium, phosphorus, and magnesium.
These nutrients are essential for bone health and can also help prevent certain diseases.
Rich in antioxidants
Rosemary is also rich in antioxidants, which can help to protect goats from diseases.
Antioxidants can also help to improve the health of a goat’s coat.
Rosemary can also help to relieve muscle pain and stiffness.
If your goat is suffering from arthritis or another condition that causes muscle pain, rosemary can help to soothe the pain.
Things to watch out for when feeding rosemary to goats
While rosemary is generally safe for goats, there are a few things you should keep in mind when feeding this herb to your goat.
First of all, you should only feed rosemary to goats in moderation. Goats can eat large quantities of fresh rosemary without problems, but they should not overeat the herb.
If you are feeding your goats dried rosemary, give them a smaller quantity, as the herb is more concentrated in this form.
Some goats may be allergic to rosemary. If you notice your goat has any adverse reactions after eating rosemary, stop feeding the herb to your goat and consult a veterinarian.
Reactions to rosemary can include difficulty breathing, swelling, and hives.
If you are growing your own rosemary, use organic methods. Rosemary plants can absorb pesticides and other chemicals from the soil, so it is vital to use organic methods if you want to avoid these substances.
If you are buying rosemary from the store, make sure to buy organic rosemary to avoid pesticides.
How often should goats eat rosemary?
Goats are creatures of habitual grazing behavior. They naturally prefer to eat small meals throughout the day rather than one large meal. Therefore, when it comes to feeding goats rosemary, it is best to give them access to the herb frequently throughout the day.
This will allow them to graze on the rosemary as they please and get the full benefits of the herb. Rosemary is rich in nutrients and antioxidants, which can help improve goat health in several ways.
Therefore, by providing goats with frequent access to rosemary, you can help ensure they get the full nutritional benefits of this important herb.
How to feed your goats rosemary
Rosemary is best given to goats fresh, but you can also use dried rosemary. If you give your goats fresh rosemary, pluck a few sprigs from the plant and let your goats munch away.
If you give your goats dried rosemary, crush the leaves into smaller pieces so that your goats can easily eat them. You can add dried rosemary to your goat’s food or hay or give it to them as a treat. Either way, your goats are sure to love it.
Can baby goats eat rosemary?
While baby goats are adorable, it’s important to remember that they are still goats and have particular dietary needs. One common question that people ask is whether or not baby goats can eat rosemary. The answer is yes, but only in moderation.
Rosemary is a type of herb that is safe for goats to eat and can offer some health benefits. For example, rosemary can help to improve digestion and boost the immune system. However, you should only give rosemary to baby goats in small amounts. If fed too much, rosemary can cause stomach upset and nausea.
So, if you’re thinking of giving your baby goat some rosemary, make sure to do so in moderation.
What other herbs can goats eat?
In addition to rosemary, goats can enjoy many other herbs. Mint, for example, is a refreshing and tasty treat that can help goats to stay cool in summer.
Lavender is another popular choice, as its calming scent helps to relax goats. Other options include oregano, thyme, and sage. All these herbs are safe for goats to eat and can provide a delicious way to get their daily dose of greens.
So, the next time you’re looking for a way to mix up your goat’s diet, consider adding some fresh herbs to their hay or grain. You may be surprised at how much they enjoy it.
How to give goats a healthy and balanced diet
While goats are generally hardy animals, they still require a balanced and nutritious diet to stay healthy. One way to ensure that your goats are getting all the nutrients they need is to feed them various foods.
Hay, for example, is an excellent source of fiber and roughage, while fresh vegetables provide essential vitamins and minerals. Goat pellets or grain can also be fed but should be given in moderation as they are high in protein and can cause digestive problems if overfed.
In addition to providing a varied diet, it is also essential to ensure that your goats have access to clean water at all times. By following these simple guidelines, you can help to keep your goats healthy and happy.
Can goats eat rosemary – final thoughts
So there you have it! Now you know that goats can eat rosemary without any problems. Feeding your goats rosemary has a lot of benefits.
So next time you’re out in the garden harvesting some herbs, make sure to leave a few sprigs behind for your furry friends. They’ll be sure to appreciate it.

domain: food


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Former Defense Minister Romuald Szeremietiew stressed the importance of the Baltic Sea in modern Central-European geopolitics during an interview in Teologia Polityczna, with the former minister explaining that in terms of security, the Baltic is key for Poland to counter threats in the region.
“First, the Kaliningrad Oblast lies at the Baltic, probably the most militarized region of the world. Next, Russian Nord Stream runs through the Baltic and it is the Baltic through which Poland conducts its gas delivery diversification – the Gasport and Baltic Pipe,” he said.
The former defense dinister added that the sea will also be important when it comes to the area of operation if Russia decided to subjugate the Baltic States.
The professor also referred to the Three Seas Initiative as a call-back to the idea of the Intermarium promoted by Poland in the early 20th century; this in turn, was a reference to the Polish-Lithuanian Commonwealth.
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Polish PM wants more US engagement with Three Seas Initiative
The Polish PM believes that the Three Seas is a project which is ‘still underestimated’ by the American side
Polish and US heads of diplomacy conduct first telephone conversation
Polish Foreign Minister Zbigniew Rau and US Secretary of State Anthony Blinken discussed priorities for cooperation
US Secretary of State Blinken backs Three Seas Initiative
The US and Poland see eye-to-eye on the Three Seas Initiative
“We must separate the attack on the Capital from Trump’s term as president,” says Polish presidential minister
The evaluation of Donald Trump’s entire term as president of the US is good for Poland and Polish-American relations, says presidential minister Krzysztof Szczerski
Opinion: The Three Seas is the most ambitious geopolitical project of our time
Central and Eastern Europe may once again become the master of its own fate, writes Stefan Tompson
Donald Trump’s legacy in Polish-American relations
Poland will remember Trump for access to the Visa Waiver Program, deepened military cooperation, energy cooperation, support for the Three Seas and many bilateral meetings
Pompeo: Three Seas Initiative will help maintain bond between US and Central Europe
The US Secretary of State believes that through cooperation with the United States, the Three Seas can ensure economic security for itself for generations
Poland and US strengthen mutual cooperation during meeting between Duda and Trump
President Andrzej Duda and President Donald Trump discuss US troops, nuclear energy and Three Seas Initiative at White House meeting
New Polish national strategy labels Russia as main threat to security
Poland’s new National Security Strategy (NSS) points to Russia as the primary threat and the Three Seas Initiative and US as primary allies
Nord Stream 2: symbol of a marginalized Central Europe
Russia is getting its way with Nord Stream 2.
Duda: “Middle East much broader issue than Iran”
President Andrzej Duda underlined that the Middle East conference planned in Warsaw in February is part of increasing Poland’s prestige, but also a duty as member of the UN Security Council. He also emphasized that Poland is a neutral territory when it comes to the Middle East.
Strategic partnership between US and Poland
USA and Poland will increase cooperation in energy and security.


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Buzz: Zoës Kitchen sets sights on 'Boro
Zoës Kitchen may be coming to Murfreesboro.
The restaurant was included in plans submitted last week to the Murfreesboro Planning Department as part of a multi-tenant development north of Medical Center Parkway, just east of the intersection with Robert Rose Drive.
With locations in Franklin, Belle Meade, Green Hills and Brentwood, the fast-casual restaurant chain serves Mediterranean-inspired fare with made-from-scratch recipes inspired by founder John Cassimus’ mother Zoë.
The menu includes many chicken salads, pasta salads, pitas, grilled chicken sandwiches with vegetarian and vegan options. The restaurants also offer “Mediterranean Family Meals” that serve four, catering and party trays.
The multi-tenant commercial development will likely be reviewed by the Murfreesboro Planning Commission at its afternoon meeting Nov. 18.
Serenity Salt Cave opens Murfreesboro location
Serenity Salt Cave has expanded its operation from Nolensville into Murfreesboro at 2705 Old Fort Parkway.
The business offers therapy through Himalayan salt and foot detoxification as well as many Himalayan salt retail products for health.
The cave is covered, floor and walls, with Himalayan salt, and a halo generator is used to break down salt into fine particles that are pumped into the air, according to the business website.
Business owner Deana Taylor touts the salt as “the most pollutant free salt on earth and contains over 84 minerals and trace elements.” She says on her website that inhaling the salt can “help promote respiratory and vascular health.”
Reach Michelle Willard at 615-278-5164, on Twitter @MichWillard orfacebook.com/DNJBusiness.


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Helps reduce anxiety and depression
CBD has shown promising results as an effective treatment for both anxiety and depression, leading many who live with these disorders to become interested in this natural approach. These medical properties are linked to CBD’s ability to act on the brain’s receptors for serotonin, a neurotransmitter that regulates mood and social behavior.
Reduces insomnia & help relaxation
CBD has been used to safely treat insomnia due to its relaxation properties.
May Reduce Acne
According to recent scientific studies, CBD and CBG may help treating acne due to its anti-inflammatory properties and the ability to reduce sebum production.
Can Alleviate Cancer-Related Symptoms
CBD and CBG may help reduce symptoms related to cancer and side effects related to cancer treatment, like nausea, vomiting and pain.

domain: biology


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I am entering this into the following challenges
Sugar Bowl - anything goes
Stamping Sensations - Special occasions
Hot Shot Crafts - anything but a card
A closer look at the image below
and then a wee look at the cupcakes I made for the baby shower.
Hope you are having a nice weekend. It is horrid weather here, the snow returned yesterday. Typical when I am on holiday and we are meant to be setting off in the caravan next week....
Thanks for visiting

domain: artistic


Otis Hensley (or 'Bullman' as the kids call him) was a candidate for governor of the state of Kentucky. In an overzealous attempt to strengthen his "Kentucky cred", Mr. Hensley engaged in a misunderstanding.
Since he was never elected to public office, Mr. Hensley has no job to leave in order to spend more time with his family.
Otis is now working on creating the world's largest waterpart/themepark/mall/airport in Kentucky, Kentucky Dolphin Splash Park. In order to raise the $499,000,000 required to build his dream, Otis has submitted a 40 page letter to President Obama.


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At Robinson Animal Hospital, our philosophy has always been that the most important aspect of your pet’s health care is the annual exam. There is nothing quite like having your veterinarian listen to your pet’s heart and lungs, feeling them from nose to tail, and just looking at how they move. As important as this is, there may be underlying issues that aren’t visible to the naked eye or even heard when using a stethoscope.
We are so pleased to now offer early detection testing for both canines and felines! There are numerous chronic illnesses which, if caught in the very early stages, can be treated by diet or a small prescription and can lengthen the life of your pet measurably.
Our early detection panel consists of a blood analysis, urinalysis and advanced fecal exam. We recommend this testing beginning at 2 years of age, but no later than 6 years of age for canines and 5 years of age in felines.
Get your pets tested annually to give them the longest life possible!
Our clients who have included wellness diagnostics as part of their annual wellness program have been fortunate enough to have pets who have lived longer, healthier lives as a result!

domain: pet


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Local hip-hop artist and producer. Tagline via myspace: "Sounds. Of. The. Observer." (the Ann Arbor Observer?)
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LocalWiki is a grassroots effort to collect, share and open the world’s local knowledge. We are a 501(c)3 non-profit organization.
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Except where otherwise noted, this content is licensed under a Creative Commons Attribution License. See Copyrights.

domain: entertainment


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- Subscribe NowLimited Time Offer
Enoch Pratt Free Library wins $3M Weinberg grant for Central branch renovations
The gift will go toward a $10 million fundraising campaign launched by the library. The funds will be used to leverage $91.6 million in state funds and $5.35 million city dollars. The total cost of the three-and-a-half-year renovation of the Cathedral Street building is nearly $107 million.
Plans for the renovation include restoring Central Hall as the library’s “Town Square,” redesigning the teen wing to support youth learning, expand computer access and a new conference room.
More than 500,000 people annually visit the Central Library, also home to the State Library Resource Center.
Construction on the project is scheduled to begin in January 2015 with an estimated completion date of July 2018.
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Controller Downtown Architectural Firm | Baltimore, MD
Program Officer France-Merrick Foundation | Baltimore, MD
Executive Director Hammond-Harwood House Museum | Annapolis, MD
Executive Director Central Baltimore Partnership | Baltimore, MD
CEO/Executive Director Family and Children's Services | Baltimore, MD

domain: news


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Deutsche Bank is in full retreat from Wall Street.
The troubled German bank says it will cutback its US operations, including trading and corporate finance operations globally as it focuses on its home market. The announcement came after the bank reported yet another quarterly losses tied to reduction in trading profits.
New CEO Christian Sewing — which I pointed out here and here led an investigation into the multiple executive suicides from a decade ago — said headcount will see a “significant reduction” in the 97,130-person workforce. Continue reading →
Bitcoin stealthily moved over the $9,000 mark overnight, despite the continuing noise coming out by financial watchdogs.
While I still believe bitcoin is the blue chip of the cryptocurrencies, over the last month’s rise it has lagged other acceptable digital currencies in appreciation. Ripple soared 85% and ethereum is up almost 65% over the last two weeks, while litecoin and bitcoin trail with roughly 36% appreciation over the same time frame. Continue reading →
The Federal Reserve — headed now by Jay Powell — released the minutes from the last meeting in March. The Fed is feeling that inflation, which has been under 2% annually for many years, is about to grow.
There is little evidence of inflation, but the Fed says that since Trump’s tax cuts gave thousands of workers a bonus and the raising of minimum wage, inflation will come and the Fed should continue raising rates. Continue reading →
President Trump — bolstered by the 750-point snap back in the Dow Wednesday — tripled down on his China tariffs Thursday stating the US was looking at an additional $100 million in imports.
Market futures on Friday morning seem to confirm that the new ploy has a much smaller effect on the markets. Futures this morning are down 200 points as oppose to -500+ Wednesday morning. Continue reading →

domain: finance


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Along with the return of “Dexter” for its eighth and final season, Showtime had a strong Sunday night.
[xfinity-record-button id=”7967342778484123112″ program_type=”series”]
The viewer tally for “Ray Donovan” was an all-time high for a drama premiere on Showtime, beating the previous record-holder, “Homeland,” which had an audience of 1.08 million for its debut in October 2011, Deadline said. (By way of comparison, the premiere of Season Two of “Homeland” in September 2012 drew 1.75 million viewers, the Web site noted.)
“Ray Donovan” stars Liev Schreiber as a Hollywood “fixer” — a man who is part private investigator and part enforcer who is assigned by a powerful law firm to “clean up” various messes afflicting the firm’s celebrity clients before the messes become public.
The show’s debut likely benefited from the publicity campaign Showtime mounted for the show over the last few weeks, combined with mostly favorable reviews. In addition, it likely benefited from its “Dexter” lead-in. That show, starring Michael C. Hall, started its eighth and final season Sunday night at 9/8c, before “Ray Donovan” at 10/9c.
“Dexter” drew 2.5 million viewers, Deadline reported — up from the Season Seven premiere which had 2.4 million viewers.
The Deadline story noted that viewership for “Ray Donovan” reached 2.22 million viewers when you factor in a second airing of the premiere later on Sunday evening.


* Unconventional supply saps U.S. interest in LNG imports
* China a growth spot in global natural gas markets
* Industry still prefers long-term contracts
By Eileen O’Grady
HOUSTON, March 10 (Reuters) - A glut of unconventional natural gas supplies from U.S. shale deposits has fundamentally recast the long-term prospects for liquefied natural gas imports that were once considered the linchpin of the nation’s energy security, industry executives said on Wednesday.
A recession-driven fall in global natural gas demand saw spot LNG prices tumble last year to around $4 per mmBtu from record highs of around $22 in 2008.
With no immediate rebound in worldwide energy demand in sight, major players in the global LNG market are focused on long-term prospects.
"There's little hope in 2010 or 2011 that the oversupply and low prices will disappear," but the prospects for 2012 and beyond are brighter, Jean-Francois Cirelli, vice chairman of France's GDF Suez GSZ.PA told the CERAWeek conference in Houston. ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ For graphic showing U.S. natural gas and oil prices click here: here ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
The dip in natural gas prices has sent global natural gas producers scrambling to change their plans.
Russian gas giant Gazprom (GAZP.MM) and partners last month delayed first LNG shipments from the giant Arctic Shtokman LNG output by three years to 2017, citing “changes in the market situation and particularly in the LNG market.”
Shtokman LNG, whose main target market is the United States, has had to adjust to a new reality in which the U.S. — once considered to be big growth LNG market — does not need incremental LNG supplies for the foreseeable future.
U.S. natural gas reserves are up by a third since 2006, thanks to unconventional gas development including shale gas, with estimated reserves sufficient to supply the U.S. market for nearly 100 years at current rates.
After 2012, executives said they expected demand to swell and prices to improve as the flexibility and climate-friendly attributes of natural gas propel it to the forefront for power generation in a world. First-ever U.S. regulations of carbon dioxide emissions could make natural gas a more attractive source for power generation.
One bright spot on the horizon is China, which has been building natural gas pipeline and import terminals at a break neck pace.
Forecasters have low-balled China’s demand for natural gas, according to Philippe Boisseau, president of gas and power and French energy giant Total (TOTF.PA).
China currently has over a dozen LNG import terminals under construction and has changed its pricing policies to attract more imports, Boisseau said.
Attractive low LNG prices currently have created demand for gas from a number of new countries not seen as LNG customers in the past, such as Chile and Turkey, which purchased LNG from RasGas last year, said Hamad Rashid Al Mohannadi, managing director of Qatar’s RasGas.
Spot pricing of LNG cargoes, while favored by buyers, will be incorporated in more LNG contracts going forward, but will not replace the traditional long-term contracts tied to oil prices used in Europe, executives said.
However, many industrial buyers prefer the certainty of long-term contracts benchmarked to oil prices, which have been the industry standard for decades.
“Our suppliers want to keep the oil-indexed and long-term contracts,” said Cirelli at GDF Suez. (Editing by Marguerita Choy)


Mikel Arteta has decided to hand Nicolas Pepe his first start since taking over as Arsenal head coach after benching the Ivorian against Bournemouth and Chelsea.
Alongside Pepe, Granit Xhaka returns to the side after illness sidelined him against Chelsea and Sead Kolasinac comes back in at left-back. Sokratis also comes into the defence as Dani Ceballos also takes a place on the bench.
Hector Bellerin hasn't been able to come back from his injury yet so Ainsley Maitland-Niles stays at right-back as David Luiz helps complete the back four.
The Xhaka/Lucas Torreira pivot returns at the base of the midfield as Mesut Ozil will look to build on his impressive start to life under Arteta. All that was missing from the German's performances at the end of 2019 were goal contributions and a full 90 minutes.
For the first time this season, Arsenal will be playing the front four of Pepe, Ozil, Pierre-Emerick Aubameyang and Alexandre Lacazette. With Arsenal fans waiting for this since the Ivorian was signed in the summer, they have reacted accordingly on social media.
There has also been some positive reaction to Granit Xhaka coming back into the side despite a possible move to Hertha Berlin in the works.
Fans have also embraced Kolasinac's return to the starting lineup after his injury layoff.
Along with all of these players returning to the starting lineup, Arteta will try to continue getting the best out of Ozil and he discussed how he plans to do so ahead of the game.
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"On his own, he cannot do it (lift the Emirates)," the 37-year-old said ahead of Manchester United's visit to the Emirates.
"That's why he needs the collective structure and organisation of his teammates. I think there are only one or two players in the world who can do things on their own.
"He needs help and he needs the team to play in a certain way to facilitate his strengths more in the game and that's what we're trying to do."


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Food2Fork makes it easy to find great recipes.
Search by name or ingredients. View Top Socially Ranked Recipes.
Pot-roast pork goulash with potatoes & greens
- 2 tbsp olive oil
- 1.5kg-2kg pork shoulder , boned and rolled
- 2 onions , sliced
- 2 tbsp smoked paprika
- 1 tsp caraway seeds
- 1 red chilli , finely chopped
- 400g can chopped tomatoes
- 1 red pepper , deseeded and cut into wedges
- 1kg potatoes , cut into quarters
- 1 green cabbage , finely sliced
- soured cream , to serve
Directions:View on BBC Good Food
Why don't we display directions?


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Sometimes the pace of life is so swift that it sweeps away ever opportunity for reflection and self-analysis. The stimulus of voices, choices and ideas pour forth like a monsoon deluge, and the deafening stream of life invades me completely. Only the deepest sanctuary of self remains intact, only the most basic of truth dwells secure and I waver, twisting against the torrent of being, at risk of loosing self. Still, the desire to continue is unfaltering, and I risk an even further journey into this mire of self-exertion.
Tonight I am in that place. Yet, just now, I found myself holding my small canine friend, bending over him, embracing his warmth and feeling the softness of his fur against my cheek and the fluff of his ear upon the base of my nose, and in the earthy smell of his being and I was reminded that I am held in the arms of God; safe. I choose tonight, for the next few moments to recline with that knowledge and my familiar upon the sofa. Come what may, I have finished this day and am done with it.


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Saturday, May 21, 2016
Saving The Marquise's Granddaughter by Carrie Fancett Pagels
Johan Rousch, a Palatine peasant, brings her to safety. This story of seeking refuge, hit a personal chord to me, as I was also a daughter of refugee parents from East Germany. So these type of events are very close to my heart. As they attempt to seek passage to the New World, again it duplicates my life but in a different century, of course. However, as a result, I was totally able to relate to the fears, the emotions and the events of the book.
Ms. Fancett Pagels has a very descriptive way of writing that brings the reader to the feeling that they can totally visualize the setting and feelings that are transpiring in the story. I really enjoyed the book and am sure you will also. Being as this book was based upon genealogical research of the author's, I can totally relate as that is what I do professionally.
The book is set to release on June 3, 2016. You can grab a copy right here!
About the author:
Carrie Fancett Pagels, Ph.D., was a psychologist for twenty-five years before becoming a Christian historical romance writer. An award-winning and bestselling author, she's previously published short stories and novellas as well as nonfiction material. Saving the Marquise's Granddaughter was inspired by genealogical research. She lives in the historic triangle of Virginia with her husband of twenty-seven years and their teen son, with an adult daughter nearby.

domain: library


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"2020 NATIONAL CAMPAIGN FOR THE PREVENTION OF CHILD ABUSE"
This is a Private Party Website. Not a Charity, Business Entity or Government Agency.
The Goldie's Secret Child Abuse Prevention and Health Assessments have educated millions of seven to ten year old American children on how to protect themselves from sexual predators. Goldie's Secret has disclosed that 10% of children assessed had become the victims of sexual abuse. Goldie's Secret is a sad success story.
Goldie's Secret staring Goldie Locks and The Three Bears and instructs with "The Good Touch Bad Touch" child abuse prevention program. Goldie's Secret created with the help of The Office of Child Abuse Prevention in Sacramento California and The San Diego City Schools Primary Prevention Program in San Diego California. Goldie's Secret includes: a 22 Minute Video, Instruction Manual, Response Cards and Crack n Peel Stickers. Individual, classroom or public performances of Goldie's Secret are available in English and Spanish language.
The health and human service agencies, schools, churches, child abuse prevention organizations that need Goldie's Secret and can't afford to purchase in this economy is staggering.. So we're granting Goldie's Secret individual, classroom and public screenings to governments, non-profits, schools, churches to all who request it
The State of California purchased Goldie's Secret puppet show assembly programs for all San Diego City Elementary Schools. Goldie's Secret is accredited with San Diego's #1 ranking in the entire United States for child abuse prevention education. But then, state budget cuts interrupted it use for one year.
Goldie's Secret's creator produced the Goldie's Secret assembly program on video and re-released it back in to the school system. But now the four person puppeteer assembly program was replaced utilizing the school teacher and video cassette or DVD player, personal computer and or CCTV television located in the classroom.
Goldie's Secret's Greatest Benefit; it's on video and the same story is told every time. This leaves little room for errors. As opposed to instructors trying to memorize a routine or coaching a child which may lead to false disclosures of sexual child abuse. The Goldie's Secret child abuse prevention program is much like having your own elementary school teacher, social worker, psychologist and police officer on call 24/7 365.
We wish to thank Don Ave, project coordinator with the San Diego City Schools Primary Prevention Program for his years of work and dedication to the children of San Diego and for his help in developing Goldie's Secret.
We also thank Robert Birchall, who spearheaded this project to be produced on video tape. Mr. Birchall made a gift of Goldie's Secret to Max Thrush, who promised him to do everything possibly to promote Goldie's Secret.
Fathers, do not provoke your children to anger, but bring them up in the discipline and instruction of the Lord. Ephesians 6:4

domain: sociology


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UPDATE: This article has been updated with a comment from Gov.Rick Snyder and some more details of August 2014 vote.
LANSING, MI - A proposal aimed at eliminating taxes that Michigan manufacturers and some other businesses pay on equipment won final approval from the Legislature early Friday morning.
The plan does not guarantee 100 percent replacement of all revenue for the cities and schools that rely on money from the personal property tax – frustrating Democrats and organizations such as the Michigan Municipal League.
Key bills in the package passed the Republican-led House by 57-52 and 56-53 votes late Thursday. The Senate voted early Friday, after which they were sent to Gov. Rick Snyder for his signature.
Phasing out the personal property tax has been a high priority for Republicans. Democrats complained that some details of the plan were not clear as the Legislature raced to approve the bills in the final voting hours of the 2011-12 session.
The proposal could replace some of the reduced taxes in part by devoting a portion of the state's 6 percent "use" tax to a special authority that would send revenues along to communities. A statewide vote, in August 2014, would be needed to approve the change in the “use” tax.
Because of legislative tiebars included in the final package, it appears the entire personal property tax reform plan would not be implemented if that vote fails.
Snyder said in a statement Friday that "lawmakers should also be commended for their work to eliminate a substantial barrier to job creation and economic growth by delivering much-needed personal property tax reform while protecting local governments and schools."
Republicans said 80 percent of the lost revenue would be guaranteed for non-essential services. Police, fire and jails would go beyond that and reach 100 percent with a special local assessment. Schools would reach 100 percent if voters approve the change in the “use” tax.
The plan would phase out the tax on industrial personal property over 10 years. It would wipe out the tax on businesses whose equipment has a taxable value of less than $40,000, eliminating about three-fourths of personal property tax returns that are filed.
Republicans who support eliminating the tax say it is outdated and works against Michigan because it penalizes investments by some businesses.
But local governments and K-12 schools that rely on the personal property tax revenue want to make sure the money they would lose by its repeal is fully replaced.


text:
Date Published: March 30, 2018
Publisher: John Wiley and Sons Inc.
Author(s): Tristan T. Hays, Ben Ma, Ning Zhou, Shaunrick Stoll, William J. Pearce, Hongyu Qiu.
Aortic stiffening is an independent risk factor that underlies cardiovascular morbidity in the elderly. We have previously shown that intrinsic mechanical properties of vascular smooth muscle cells (VSMCs) play a key role in aortic stiffening in both aging and hypertension. Here, we test the hypothesis that VSMCs also contribute to aortic stiffening through their extracellular effects. Aortic stiffening was confirmed in spontaneously hypertensive rats (SHRs) vs. Wistar‐Kyoto (WKY) rats in vivo by echocardiography and ex vivo by isometric force measurements in isolated de‐endothelized aortic vessel segments. Vascular smooth muscle cells were isolated from thoracic aorta and embedded in a collagen I matrix in an in vitro 3D model to form reconstituted vessels. Reconstituted vessel segments made with SHR VSMCs were significantly stiffer than vessels made with WKY VSMCs. SHR VSMCs in the reconstituted vessels exhibited different morphologies and diminished adaptability to stretch compared to WKY VSMCs, implying dual effects on both static and dynamic stiffness. SHR VSMCs increased the synthesis of collagen and induced collagen fibril disorganization in reconstituted vessels. Mechanistically, compared to WKY VSMCs, SHR VSMCs exhibited an increase in the levels of active integrin β1‐ and bone morphogenetic protein 1 (BMP1)‐mediated proteolytic cleavage of lysyl oxidase (LOX). These VSMC‐induced alterations in the SHR were attenuated by an inhibitor of serum response factor (SRF)/myocardin. Therefore, SHR VSMCs exhibit extracellular dysregulation through modulating integrin β1 and BMP1/LOX via SRF/myocardin signaling in aortic stiffening.
Aortic stiffening is a fundamental component of aging‐related vascular diseases (McEniery, Wilkinson & Avolio, 2007; Wallace et al., 2007). Increased aortic stiffness, whatever the underlying cause, is also an independent predictor of outcomes of cardiovascular diseases in the elderly. It is well known that hypertension is a highly age‐related human disease. Despite a widely held belief that increased aortic stiffness in hypertensive patients is largely a manifestation of long‐standing hypertension‐related damage, a recent statement from the American Heart Association (AHA) asserts that aortic stiffening is a cause rather than a consequence of hypertension in middle‐aged and older individuals (Townsend et al., 2015). This new concept further clarifies the cause and effect relationship between aortic stiffening and hypertension in aged individuals. Additionally, our previous studies in monkey have demonstrated that aortic stiffening is also strongly associated with aging (Qiu et al., 2007). Specifically, our recent studies with atomic force microscopy (AFM) have demonstrated similar characteristics of aortic vascular smooth muscle cells (VSMCs) in both aging and hypertension, indicating that VSMC‐mediated regulation is a fundamental basis of aortic stiffening in both conditions (Qiu et al., 2010; Zhou, Lee, Stoll, Ma, Costa, et al. 2017; Zhou, Lee, Stoll, Ma, Wiener, et al. 2017). However, the underlying mechanisms are not fully understood. It is conceivable that, in addition to intracellular effects, VSMCs are able to contribute to aortic stiffening via extracellular effects. However, it is difficult to discern the extracellular effects of VSMCs in intact aortic tissue in vivo. Our previous study successfully distinguished the role of VSMCs from the extracellular matrix (ECM) in aortic stiffness in vitro utilizing a three‐dimensional (3D) tissue model reconstituted system consisting of isolated VSMCs and collagen (Qiu et al., 2010). This model also provides the necessary simplicity to characterize interactions between VSMCs and the surrounding ECM and explore the molecular mechanisms mediating these changes.
This study integrated in vivo, ex vivo, and in vitro experiments to identify the individual components that contribute to aortic stiffness. We first determined the contributions of the crucial medial layer to aortic stiffening, which is independent of endothelium and adventitia. Second, use of a 3D reconstituted vessel revealed that VSMCs are essential for aortic stiffening, independent of the ECM in the medial layer. The data from both ex vivo native tissues and in vitro reconstituted tissues complemented our previous studies of single VSMCs (Zhou, Lee, Stoll, Ma, Wiener, et al. 2017) and emphasize the importance of VSMCs in aortic stiffening.
H.Q. conceived and designed the study. H.Q., T.H., B.M., and W.P. designed and performed ex vivo and in vitro experiments, analyzed the data, and wrote the manuscript; N.Z. and S.S designed, performed, and analyzed the in vivo experiments. All authors discussed and analyzed the results and reviewed and approved the final version of the manuscript.

domain: literature


Control And Needle Valves
Established in year 1986, we are known for manufacturing and exporting an innovative range of Control Valves. These valves are used in flow metering application when a constant, calibrated and low flow rate must be maintained. Our Needle Valves are hugely demanded in industries like textile, chemical, petrochemical, fertilizer, paper, plywood and rubber. We have with us the support of veteran engineers and ultramodern machines to manufacture these valves as per the norm set by the international market.Features:
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- Recognized for their enhanced service life, rugged construction and rust proof body
- These are easy to install and require zero maintenance.


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Binge Eating Disorder
Get the facts about binge eating disorder, including symptoms, causes and related conditions.
- Birth Control Facts about birth control to help decide which type is right for you.
- Type 2 Diabetes Basic facts about type 2 diabetes & risk factors to be aware of.
- Binge Eating Disorder Facts about binge eating disorder, including symptoms and causes.
- Eating Disorders Facts about different types of eating disorders.
- Flu Facts about influenza (flu), including symptoms and vaccines.
- Food Allergy Facts about food allergy, including the symptoms and signs.
- GERD Get the facts about gastroesophageal reflux disease (GERD).
- Gout Get the facts about gout, including the risk factors.
- Home Allergies Facts about indoor allergies, including symptoms & common allergens.
- Chronic Idiopathic Constipation Learn about chronic idiopathic constipation, including treatment
- View All Care Guides Prepare for your next visit with our extensive library of Care Guides
About Dr. James Dye
Dr. James Dye, MD, PA is a Doctor primarily located in Kennett, MO, with other offices in Blytheville, AR and Paragould, AR. He has 30 years of experience. His specialties include Family Medicine and Emergency Medicine. Dr. Dye is affiliated with Arkansas Methodist Medical Center, Twin Rivers Regional Medical Center and Smc Regional Medical Center. He speaks English.
Dr. James Dye has the following 2 specialties
- Family Medicine
A family practitioner is a doctor who specializes in caring for people of all ages, at all stages of life. Rather than focusing on the treatment of one disease or patient population, family practitioners are often the doctors that people see for...
- Emergency Medicine
An emergency physician is a doctor who is an expert in handling conditions of an urgent and extremely dangerous nature. These specialists work in the emergency room (ER) departments of hospitals where they oversee cases involving cardiac distress,...

domain: medical


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Hi, welcome to the listing.
Vypex was started in 2015 as a gym clothing brand by a full-time University student.
Long story short, the brand has since slowly moved away from this, now tailoring it's offering towards "active streetwear".
I am looking to sell the business as I am entering teaching this year and simply will not have the time to continue with the business. It's been a great secondary income generator for me but there's simply not enough hours in a day for me to juggle both.
I can provide you with numerous supplier relationships, customer databases, ideas, social media pages, trademarks and existing stock.
Humungous potential, I just don't have the time to unlock it. I'm a 23 year old Computer Science teacher with a mortgage and bills to pay. This secondary income has slowed down for me as there's not enough hours in the day to juggle it all!
VALUATION INCLUDES EVERYTHING FROM TRADEMARK TO PRODUCT INVENTORY, THE SHIPPING OF INVENTORY AND ALL OTHER MARKETING MATERIALS (PRINTED) THAT WE HAVE.
The infrastructure is here - it's up to you to unlock it and make it happen now.
**HAPPY TO NEGOTIATE**
Over $9k in revenue in the last 12 months - 5 months were below $200 USD sales (again, didn't have the time to manage it). Just shows how much this business can make per month if you dedicate the time to it!
Financials and traffic
Revenue and traffic data from this graph is calculated by Exchange and can not be edited by the seller. Average profit, profit margin and number of sales are provided by the seller. Learn how Exchange calculated this data.
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domain: economics


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Low Cost Apparatus
Apparatus Title: Apparatus for determination of diffusion coefficient by refringence variation
Abstract : It consists of a pointer laser which light impinges on a cylindrical lens. The lens forms 45° with the horizontal. The light coming from the lens, impinges perpendicularly on a glass cell which contents two liquids of different concentration in contact. The diffusion coefficient can be obtained from the time height image change of the light coming from the laser.
Equipment required to construct apparatus:
Sketch of the apparatus
Here we describe a simple physico-chemical system which allows to obtain the diffusion coefficient from the analyses of the deviation of the laser light. The elements are disposed on wooden supports as it is shown in the sketch.
The narrow cell is built with two pieces of glass glued to an O-ring in such a way that the resulting cell is about 5mm wide. The light from the pointer laser impinges on the cylindrical lens (acrylic rod), which forms 45° with the horizontal.
The light coming from the lens, impinges perpendicularly on the glass cell which contents two liquids of different concentration in contact. The image is collected on a screen which is about 2 meters far from the cell. The image changes with the time. The diffusion coefficient can be obtained from the time height image change of the light coming from the laser.
The law that governs the diffusion phenomenon are fundamental for the description of cells, chemical reactions, etc. If two liquids of different concentration are in contact, a molecule or ion migration from one liquid to the other through the interface will be produced until the difference of concentration be null. This behavior can be described by Fick´s laws. The first Fick´s law expresses:
When a light ray impinges in a medium where there is a refraction index gradient the ray curves in the gradient direction. The following plot shows how the light coming from a ray laser curves when passes through the cell where the refraction index varies.
From this expression it is possible to obtain D by plotting 1/H^2 versus t.

domain: chemistry


DDTV is here! It’s the Doncaster Rovers YouTube and iFollow Rovers show for kids, by kids, and starring kids.
There will be regular episodes of Dogglebox, FIFA with the players, and fun games and challenges to enjoy as well as offering plenty of opportunities for young Rovers supporters to be involved whether that is starring in the show, contributing with show ideas, or sending in clips from home - just email email@example.com to register your interest.
DDTV will make its debut with Dogglebox, a short mini-series where players, fans and Donny Dog watch back match highlights from the season.
Visit Rovers’ brand-new family website with information about first-time visits, purchasing tickets, planning your visit, as well as providing games and activities for young fans to enjoy. Visit now: www.roversfamily.co.uk


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Massive Disneyland Attraction Database
Pictured: Maleficent's House and Hound Maleficent, a favorite attraction of Slinky Dog
Maleficent's House and Hound Maleficent
May 21, 1976
Avg. queue length:
After you meander
through Maleficent's house, you'll be able to queue up for his Film Coop in the "back yard". There you can find Maleficent once again filming a scene from his most famous film, "Steamboat Jilly". Be sure to avoid confusing him with Smee!
- Warning: just before Thanksgiving, this attraction will be uncomfortable for vampires.
- After waiting for this attraction, you might find it pleasant to style something more thrilling.
- Minimum height 27" (or 13.5" and being carried).
- Darkness may be too unsettling for very young tweens.
- Guests may get very dry on this attraction.
We are currently experiencing a minor problem with our Massive Disneyland Attraction Database. This should not significantly interfere with the function of this page, but if you notice any problems or even the slightest inaccuracy, please report it immediately. Thank you for your understanding.


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The very first World diversity Leadership Summit Europe under the patronage of the Austrian Vice Chancellor and Federal Minister Finance, Josef Pröll took place in Vienna from March 11th-12th 2010. Conference Venues were the Federal Ministry of Finance and the Vienna Chamber of Commerce and Industry.
WDLS-EU Organiser and Conference Manager Beatrice Achaleke opened the Conference by situating WDLS-EU in global and European context with its enormous challenges and potential. Achaleke concluded by saying WDLS-EU is not only very timely but has the potential to offer new answers to old questions in a very challenging time.
WDLS founder Douglas C. Freeman compared a good diversity concept to a gold mine. “Diversity is not only a financial plus for companies but also represents an enormous increase in human capital for society” he pointed out.
WDLS-EU patron Mr Josef Pröll in his welcome address pointed out amongst others that the future of our ever-aging society lies in diversity.
Facts and figures in overview
*232 Registered attendees
* 76 High-ranking Diversity thought leaders as speakers
* 96 Participating companies
* 20 National and international organisations
* Excellent combination of Business, policy-making bodies and other stakeholders
* High level representation of Academia, Media, Research etc
* Involvement of high ranking diplomats (Ambassadors of USA, UK and Canada
* Local, regional and global perspectives (Europe, America and Africa)
* Broad selection and combination of keynotes, panels, split-up sessions, and remarks
WDLS-EU 2010 PANELS included:
* Gender, Sexual orientation + (Dis)abilities
* Return on Investment
* Recruiting and managing diversity talents
* Demographically changing environment
* Global affinity groups
Two split-up sessions focused on
1. Supply and marketplace diversity featuring: a) Ethnic minorities
* b) Healthcare
* c) Working parents
1. 2. comparative advantages of European and global diversity and inclusion by 2020 featuring:
* a) Global CSR
* b) Education and Research
* c) Audiovisual, print and social medial networks
*Douglas Freeman (WDLS founder)
* Wolfgang Ruttenstorfer ( CEO OMV)
* John Barrett (Ambassador Canada to Austria)
* William C. Eacho, III (U.S. Ambassador to Austria)
* Josef Pröll (Vice Chancellor, Austrian Federal Minister of Finance and WDLS-EU Patron)
* Michael Stuber General Manager, European Diversity Research and Consulting
* Ellen Seßar-Karpp, Chief of Baord, filia diefrauenstiftung
* Carmen J. Smith Vice President Global Strategy, Walt Disney Parks and Resorts
* Helmut Naumann (Head of the Department of Economic Policy Vienna Chamber of Commerce and
*Opening keynote by Andrés Tapia (Chief Diversity Officer / Emerging Workforce Solutions Leader
* Dinner Keynote by Lord Michael Hastings (KPMG ‘s Global Head of Citizenship and Diversity)
* Luncheon Keynote by Hans Jablonski (Economist M.A. & Senior Consultant, Director of Jablonski
* Closing Keynote by Christian Baldia (Managing Director, Virtcom Consulting)
Special Dinner Guests
* Rudolf Hundstorfer (Austrian Minister for social Affairs and Consumer Protection)
* Helen Pickering (Deputy Head of Mission, Consul General and Director of Trade and Investment,
British Embassy Vienna)
* Simon Smith (Her Britannic Majesty’s Ambassador to the Republic of Austria)
* Reinhold Lopatka (States Secretary Austrian Federal Ministry of Finance)
WDLS-EU, Vienna 2010
24th -25 March 2011
Watch out for our call for speakers and registration coming up soon!
[…] This post was mentioned on Twitter by BWIE. BWIE said: World Diversity Leadership Summit Europe, Vienna 2010, a quick retrospective http://bit.ly/9oX5GB […]
Did you attend?
It is exciting to know we have strong and powerful women in Europe doing their thing.
I was unable to attend this year. Hopefully that won't be the case in 2011.


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Mrs. Helen Lumpkins Robinson Day was a well-known teacher at Parker-Gray School and at Charles Houston Elementary School. She was born in Alexandria, VA in 1905. She was a trailblazer in advocating for a daycare center for African Americans. She was on many committees and raised money for many disadvantage African Americans.
“The Other Alexandria’s Column,” in the Alexandria Times Newspaper
For Black History Month, I would like to highlight two articles that I wrote. The second article written this month in February 2022; I wrote an article on Mr. Holland who was a teacher at Parker-Gray School. He wanted the students to have the same activities that were available in the white high schools. Mr. Holland volunteered as a coach and recruited other teachers until funding was allocated for a full-time coach.
Mr. Holland taught at Parker-Gray from 1933 to 1965. He retired in 1966 but did not stop teaching. He became a substitute teacher staying in the school system until he was 82-years old.
Behind the scenes of the article titled, “Sarah A. Gray: Principal of Hallowell School.”
Sarah A. Gray was one of two people that Parker-Gray School was named after. She was a remarkable woman who was educated as well as a talented pianist and an organist.
Due to the death of her father, William Gray and two lawsuits, Sarah started experiencing health issues. Her father, William Gray died in 1891.
Sarah filed two lawsuits against Reverend Robert H. Robinson’s son, Reverend Robert B. Robinson, for slander. The other lawsuit was against her stepmother and relative, Alfred Peters concerning her father’s estate. Due to these heavy burdens, Sarah died in 1893 – just two years after her father.
A detailed article is available in the Alexandria Times dated, September 9, 2021 on, “Sarah A. Gray: Principal of Hallowell School on pages 17 and 18 at
I was privilege in having a conversation with the 78 year-old Leroy Council of Philadelphia who revealed his deep love for his mother, Margaret and the history she shared with him about her life in Alexandria.
His mother, Margaret was born in Alexandria on April 19, 1917. Margaret’s mother came to Alexandria from Orange, Virginia to have her. After she was born, her mother returned to Orange County with her daughter, Margaret.
Margaret’s grandparents, Phillip and Alice Perry Campbell raised her. Out of their great love for their grandchild, Phillip and Alice moved to Alexandria in 1922 so that Margaret could get a better education.
Margaret left Alexandria after the death of her grandparents. She moved to Philadelphia to be with her mother. She came back to Alexandria to get married. She raised her children in Philadelphia but kept her close ties with friends and family in Alexandria. She never missed an opportunity to return to Alexandria to be with family and her childhood friends.
You can read Margaret’s story in the Alexandria Gazette Newspaper that was published on March 30th at:


LG 6871JB1423N Refrigerator Control Board Assembly
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Electronic control board 6871JB1423N manages the functions of the refrigerator such as cooling and defrost times.
Unplug the appliance before installing this part.
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|79577712700||79577713700||79577719700||79577729700||LFC21760ST (ASTCLGA)||LFC25760SB (AWBCLGA)|
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A new Canadian-made Internet search tool that detects child sexual abuse images online has logged more than five million unique web pages with 40,000 images in the past six weeks alone, the Toronto Star has learned.
Project Arachnid, created by the Winnipeg-based Canadian Centre for Child Protection, is searching 150 web links a second for child abuse imagery in an effort to have it removed from public view, a form of lingering abuse for victims.
When the search tool identifies illegal material, the centre sends notices to the site host requesting its removal.
“If we can make this content more difficult to find, the breadth of exposure for victims will diminish over time,” says Signy Arnason, director of Cypertip.ca, a project of the Centre which receives tips about child abuse from across the world.
One of the most powerful findings from an international survey of 128 child abuse victims being released today by the centre is the lifelong impact that exploitative images published online can have on victims, including ongoing paranoia and fear of being stalked, sleeplessness, poor self-image, “powerlessness” and “shame and humiliation.”
“The fact that images/videos of a child’s sexual abuse were created at all, not to mention that they may still be possessed by the abuser and be publicly available for others to access, has an enormous negative impact on the individual,” the study says. “The impact can perpetuate into adulthood and may reduce the ability of an individual to recover and function in society.”
Among respondents, 73 per cent said they worry about being recognized; 88 per cent believe it has affected their education/academics; 91 per cent believe it has affected their employment; and 93 per cent believe it has affected friendships.


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Grace's class is collecting pieces of cypress mulch that have a naturally occurring hole. Apparently they are going to be used to create nature necklaces which will then be sold to raise money for a local charity. So each time we take Sophie out in the backyard we're on a hunt. Our last search was the most successful yet, yielding five pieces.
Oh, I neglected to mention the motivation behind this project. For each piece of mulch Grace finds, she's able to exchange it for a fairy stone - which is great motivation indeed!


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Pine wood boards are excellent for making furniture, creating an art piece, or any number of creative uses! The 100% solid pine wood boards are easy to mill or manufacture, and easy to stain and paint. You can leave it unfinished for a natural look or let your creativity shine!
A few ideas for these Panels are handmade furniture, shelving, bookcases, tables, and more!
1. Custom made to order from random width lumber.
2. Glued up and dimensioned to your specified size.
3. Thickness and length at your choice.
4. Care is taken to match grain, figure, and color.
5. Large quantities available with several days notice.
6. Panels are not trimmed to length, but have sufficient over length.
Minimum Order Quantity: 5CBM
Packing Method: Standard Pallet package to keep the goods in safe condition
Payment Term: T/T or Letter of Credit payable at sight
Inspection: One piece by one piece to guarantee the best quality. Free sample could be sent for quality test at first.
Shipment Time: We could arrange immediate and quick production or directly supply from available stock after the receipt of your deposit. For common orders, the goods could all be ready for shipment within 1 month.

domain: design


text:
Tools To Become a Permanently Profitable Business
By guiding you through the Profit First method, we help you implement the necessary financial and operational process improvements that will maximize your cash flow. This system provides you with the tools and clarity needed in order to fully understand and interpret financial statements so that you can feel confident in making informed business decisions.
Change Your Mindset
Assess Your Books
We’ll guide you through a full profit blueprint to provide you with the reality of your business’s current profitability.
Based on this blueprint, we’ll develop a strategic plan that is tailored to your goals.
Roll-Out Your Plan & Repeat
Profit First FormulaInstead of the traditional accounting formula Income - Expenses = Profit, we use:
Income – Profit = Expenses
How Do I Know if
I’m Ready for a Profit Consultant?
Every entrepreneur needs a system that will ensure their business can sustain and grow.
You are stressed
If your business finances keep you on edge, wake you up in the middle of the night, or you’re borrowing from Peter to pay Paul, you are ready.
You have no idea how much you make
Even if your books are being “done” on a regular basis but you don’t know how much you’re making, what your margins are, and are wishing you could pay yourself, you are ready.
You have looming debts
Do you have debt and think you can’t be profitable until it’s cleared up? There is a better, proven way to think. Gather your debts and numbers because you are ready.
Here’s What You’ll Get


Create an Account - Increase your productivity, customize your experience, and engage in information you care about.
January 21, 2021, 10:00 AM - 12:00 PM @ Virtual - Zoom
Public comment will be accepted by mail, email, and virtually in accordance with CDC social distancing guidelines. No in-person attendance or public comments shall be permitted.
By Email: email@example.com
By Mail: Montgomery County Board of Commissioners, P.O. Box 311, Norristown, PA 19404
Virtual: Residents may login during the meeting to provide comment virtually through Zoom. Click here to register.
Public live stream: Montgomery County’s Facebook page
January 21, 2021, 7:00 PM - 8:00 PM @ Virtual - Zoom
View all calendars is the default. Choose Select a Calendar to view a specific calendar.


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Collie Eye Anomaly in dogs is a congenital, inherited eye defect that occurs when mutated chromosomes impair the development of the blood vessels that nourish the retina.
The retina, sclera, and choroid of both eyes are typically affected, making it a bilateral condition, or one that occurs on both sides of the body.
Collie Eye Anomaly also referred to as Collie Eye Defect, can also cause retinal detachment.
As the name suggests, Collies are most often affected by this eye disease.
Need Pet Insurance?
FACT: Pet insurance pays up to 90% of vet bills when your pet is sick or injured!
Breeds Affected By Collie Eye Anomaly
While there are virtually no symptoms with the disease until it is too late, your veterinarian can diagnose the condition through genetic testing.
Symptoms Of Collie Eye Anomaly
- No symptoms may be present
- Later stages may bring on associated eye conditions
- Final stages may be blindness
Associated Conditions Of Collie Eye Anomaly
- The eyeballs are smaller than normal.
- The eyeballs are sunken in their sockets because the connective tissue of the cornea has become mineralized and looks like a cloud over the eyes.
- When the layers of the retina aren’t formed together properly.
Real Cost Savings from Nationwide Clients
Nationwide insurance saved his parents
Senta got a bone disease called hypertrophic osteodystrophy. Therapy and drug treatment cost $7,770. Senta is now back to his playful self.
Collie Eye Treatment
For some related eye defects, like coloboma, surgery can help reduce the effects of this disorder. Laser surgery is the most common choice.
Another type of eye surgery, called cryosurgery, uses extreme cold to prevent detachment of the retina or further deterioration of the eye.
Surgery might also be able to help reattach the retina if necessary.
What Causes Collie Eye Anomaly
This defect only affects dogs that have a parent that carries the genetic defect of mutation.
The parents might not even be affected by the chromosomal defect even if they carry it. But, the litter of such parents could carry the mutation and have the effects of the disease.
Other genes might also play into this chromosomal defect which is why not all collies are affected.
This test can be done when your dog is a puppy which is always recommended.
The most common sign is retinal detachment and if caught in the early stages, the disease can be prevented or the symptoms minimized.
If collie eye is detected, it won’t worsen unless it has reached the stage of coloboma, which can be a fold in the retina, iris, optic disc or lens.
The size of the hole can be very little and not affect your dog’s vision.
However, if the hold is larger it can lead to blindness and/or retinal detachment.
If coloboma is found, your vet will need to monitor the condition. Some puppies might develop pigment around the affected area but the eyes will still look normal.
Pet Insurance Can Help With Collie Eye Anomaly
If you have a collie or any of the herd dogs that are prone to this condition, early eye exams of your puppy in the first six to eight weeks of your puppy’s life is highly recommended.
Pet insurance can be very helpful to cover many of these costs, even if your puppy or dog doesn’t yet have the condition.
Pet insurance can help with not only the cost of testing and all the medical bills for this disease but also any related eye conditions that might occur.
We recommend Healthy Paws as the #1 pet health insurance provider!
Fetch Rates With Healthy Paws!
Managing Collie Eye
If your puppy is diagnosed with coloboma in his or her first year, it’s important for your vet to look to see if there is also a retinal detachment. If not after a year, your puppy should be OK.
As with any eye condition, your dog should be monitored carefully for any of the related eye conditions in puppyhood throughout your dog’s adult life.
How Do You Prevent Collie Eye Anomaly?
There is really no way to prevent the occurrence of collie eye anomaly in dogs. If a dog does carry the mutated chromosome, it should not be bred with other dogs to produce offspring.
If however, an adult has a mild condition, there is a chance it would be passed along to her offspring.
The good news is that your dog can live a long, fulfilled life even with the disease. And it has little or no effect on your dog’s lifespan. Even if your dog loses his or her sight completely, he or she can live a fulfilled life.
Return to the Dog Health Problems glossary.
Other articles you may find helpful:
We get it, your dog is like your child and when your puppy or dog has health problems it is scary. Luckily there is pet insurance companies that will help you pay for any veterinarian care they made need. Checkout the best puppy and dog pet insurance companies and learn about common puppy health issues and ailments in older pets.
Common Health Problems:


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Analysis & Lab Equipment
Setaram - FLEXI HP MS
Your Flexible High Pressure Mass Spectrometer
FLEXI HP MS is based on standard elements like a turbomolecular pump and a quadrupole mass spectrometer (MS).
It also features a proprietary dosing system able to sample gas at high pressure. The sample is then depressurized and analyzed. It can also operate in the flow mode like any other mass spectrometer.
The fields of application of FLEXI HP MS are wide. It can analyze gases at-line in systems like reactors, laboratory instruments or climate chambers. So it can be useful in application fields like energy & environment. It includes hydrogen storage materials, catalysts characterization or oil & gas fields.


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Please Note: This event has expired.
Dia del Nino KiDDay Festival
In Mexico, Día del Niño (Children’s Day) is always filled with activities, and children look forward to a holiday all their own with fun, gifts and special events. This is Center’s 6th Annual festival focuses on active engagement by community members — creating and participating in art rather than simply observing. The major focus will be on kids themselves, and so part of center stage performances will be children.
Healthy food and beverages will also be available. The Sacramento River CatsView more
Contact: (916) 446-5133
2700 Front St, Sacramento, CA 95818


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Marriage is among the most important events in Kazakh lifestyle. It is an incredibly significant event that permits the recently married to enter into a fresh life as a whole family. The marriage ceremony requires several customs and customs which have been passed down out of generation to generation. Some examples are dowry, the “Betashar” ceremony, plus the Neke qiyu.
The dowry is often comprised of home appliances, bed linen, furniture, and carpets. This money is given to the bride’s parents to get items that are necessary for the newest bride to have comfortably in her new home. Traditionally, the dowry was made from 47 heads of cows. However , today, this tradition is definitely outdated.
The Betashar formal procedure is a traditional Kazakh rite that may be performed prior to the wedding. It includes the vocal singing of a unique tune called zhyr and dombra. The dombra is a nationwide Kazakh tool that is enjoyed in the wedding. It is usually designed with gold and silver coins and beans. It is performed having a white headband that symbolizes marital status. It is also ways to open the bride’s experience.
Besides the dowry, the wedding ceremony also involves the introduction of the newest wife with her family members. Jane is tested simply by her family to determine her upbringing. She’s then granted presents by simply her family members. These kinds of gifts can vary from charms to a support for her infant child.
During the Soviet period, most of the Kazakh marriage traditions and customs were suspended. The tradition of dowry was belittled as it avoided young women of all ages from going into the staff and offered their parents a way to get wealthy quickly. Additionally , the Adat marriage bar was likewise in place. This ban meant it was illegal to get a Kazakh to marry an individual of his clan who had been at least eight years over the age of him.
Another well-liked tradition is definitely the Kyz Uzatu, or presenting the girl in marital relationship. This is a ceremony that is held at the residence of the woman or groom. A number of people, approximately 300 to 500, are invited from your groom’s part of the family unit. They present the bride-to-be with products, and the newly married couple bows to their friends.
Wedding marriage ceremony is as well as a banquet. Typical Kazakh dishes will be beef tongues, onions, horses meat sausage, and vast noodles. A boiled meats sausage is additionally served. The dish named kuyruk bauyr, or perhaps five ring finger meat dish, is a very famous Kazakh meal. The bride is dressed in a white scarf and a nice attire. The newly married couple is normally served by a large floor table.
The recently married couple is then presented with a gift in a special cup. In this wedding ceremony, the recently married couple will get advice in order to lead a cheerful family existence. Also, they are congratulated by their partner’s family.
In the early days of marital relationship, a girl was often committed when she was thirteen or perhaps fourteen. Your sweetheart was placed away from her father’s residence for a 12 months after the wedding. This helped maintain youth out of becoming sexually promiscuous and obscene. Additionally, it https://gunillalarborn.com/2020/05/21/how-a-singles-internet-dating-industry-has-developed/ contributed to the development https://asianwomenonline.org/kazakhstan-girls-for-marriage/ of healthful babies.


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Social anxiety disorder can lead to depression and anxiety and can impede people's functioning in jobs and relationships. It is often thought to run in families but the genetic risk is modest suggesting that parenting and environment play a part too. Researchers know very little about how upbringing affects children's chances of developing anxiety disorder but some researchers think that the way in which children interpret what is going on around them and the influence their parents have on this could play a part. A team of researchers from the University of Amsterdam in the Netherlands looked into this issue further in a study of 144 children aged between eight and 12. The children were presented with a series of ambiguous social scenarios in which either the father or the mother acted anxiously or confidently. In children who were highly socially-anxious the father's behaviour had a greater influence on their levels of confidence or anxiety but for children who had average or low levels of social anxiety the mother's role was more important. The results suggest that fathers could have an important role to play in boosting the confidence of socially-anxious children.
Bogels, Susan, Stevens, Juliette and Majdandzic, Mirjana - Parenting and social anxiety: fathers’ versus
mothers’ influence on their children’s anxiety in ambiguous social situations Journal of Child Psychology and Psychiatry doi:10.1111/j.1469-7610.2010.02345.x


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Mining, smelting metals (like zinc, lead and cadmium) and steel production, as well as burning coal and certain wastes can release zinc into the environment. A common use for zinc is to coat steel and iron as well as other metals to prevent rust
some mining districts, the lead or zinc is found in massive deposits and mined similar to coal using room and pillar methods. 6.1.2 Lead and Zinc Ore beneficiation Due to low zinc content, run-of-mine zinc-bearing ores must be concentrated before smelting and refining.
Zinc is the 23 rd most abundant element in the earths crust. Sphalerite, zinc sulfide, is and has been the principal ore mineral in the world. Zinc is necessary to modern living, and, in tonnage produced, stands fourth among all metals in world production - being exceeded only by iron, aluminum, and copper. Zinc uses range from metal products ...
$1.6 billion. Zinc was mined in five States at 14 mines operated by five companies. Three smelter facilities, one primary and two secondary, operated by three companies, produced commercial-grade zinc metal. Of the total reported zinc consumed, most was used in galvanizing, followed by brass and bronze, zinc-based alloys, and other uses.
Zinc Dust is one of the dusts that are used in GregTech. There are two main ways to obtain zinc The first method is to process Tin Ore in an Industrial Grinder at the rate of 1 tiny pile of zinc dust per ore. The second method is to mine Sphalerite Ore found in the Nether. Zinc Dust can be smelted into Zinc Ingots, which can, in turn, be used in Mixed Metal Ingot production.
May 04, 2013 The Effects Of Zinc On Plants 15 Aug 2010 Plants use zinc in creating chlorophyll, but in areas where soil is It occurs naturally in soil but more is being released into the environment by humans, especially from mining. Zinc Vitamin Benefits and Disadvantages More detailed
Jul 27, 2016 ZINC-DUST PRECIPITATION OF GOLD. For many years precipitation by zinc dust, as by the Merrill-Crowe process, has been recognized as the most efficient and economical method of precipitating gold and silver from cyanide solutions.Embodying precipitate filters of the plate-and-frame type, of the vacuum-leaf type, or of the more recently developed pressure bag
Zinc metal uses, such as galvanized steel and zinc sheet, are known for their durability. Zinc metals are recycled with high collection and EoL recycling rates. When zinc is used as fertilizer it moves from the technical into the biological cycle and returns to nature. This circular economy contributes to the UN SDGs 9, 11, and 13.
Historic Uses of Zinc. Centuries before it was identified as an element, zinc was used to make brass (an alloy of zinc and copper) and for medicinal purposes.Metallic zinc and zinc oxide were produced in India sometime between the 11th and 14th centuries and in China in the 17th century, although the discovery of pure metallic zinc is credited to the German chemist
April 4, 2006EPA publishes Criteria for the Safe and Environmentally Protective Use of Granular Mine Tailings Known as Chat (71 FR16729). In this proposed rule, EPA proposes criteria for the environmentally protective use of chat (a gravel-like waste created from lead and zinc mining activities in the Oklahoma, Kansas, and Missouri ...
Relation to Mining. Zinc is recovered from a number of different zinc minerals. The most significant of these is sphalerite. Other minerals, such as smithsonite (ZnCO3, zinc carbonate), and zincite (ZnO, zinc oxide) are also zinc ores. Zinc is also recycled from scrap. Uses. Zinc alloys well with other metals resulting in stronger, harder metals.
Aug 06, 2021 Uses Zinc Dust. Hydrometallurgical / Mining Applications. Zinc powder is applied as a type of precipitant. It is intended for purifying various solutions, which contain the metals, like Cadmium, Copper, Silver and Gold, these minerals can
$2.1 billion. Zinc was mined in six States at 15 mines operated by five companies. Two smelter facilities, one primary and one secondary, operated by two companies, produced commercial-grade zinc metal. Of the total reported zinc consumed, most was used in galvanizing, followed by brass and bronze, zinc-based alloys, and other uses.
Zinc can enter the body through the digestive tract when you eat food or drink water containing it. Zinc can also enter through your lungs if you inhale zinc dust or fumes from zinc-smelting or zinc-welding operations on your job. The amount of zinc that passes directly through the skin is relatively small. The most likely route of exposure
Sep 23, 2013 Today, Zinc is primarily used to coat and protect steel from corrosion. It has been used in this manner for over a century. Zinc coated (galvanized) steel is the most effective and inexpensive way to protect steel from the corrosive effects of weather, temperature, and oxygen. And, PZMs zinc dust is used in Industrial Coatings to protect ...
Most of the cadmium is precipitated using a zinc dust addition. The purified zinc sulfate solution is sent to the cellroom, and metallic zinc is recovered from the solution by electrowinning. The cadmium precipi tate is sent to the cadmium plant where it is filtered and pressed into a cake containing cadmium, zinc, and minor amounts of copper ...
Zinc is used to form various chemicals, like Zinc Phosphide, Zinc Sulphate, etc. To refine Zinc Metal at the time of manufacturing through the electrolytic process. Applied for nitrobenzene production and as a catalyst and polymerizing element. For the synthesis of various organic compounds for ...
Zinc dust is applied for forming friction to alter the properties. It also improves performance in higher temperature. Thus, these are the major applications of Zinc powder, and you have to use it rightly to get the best result.
The primary uses of zinc are for galvanizing steel to protect against weather and corrosion, producing brass and bronze, and in die-casting to produce a wide range of metal products. Zinc can increase crop yields and crop quality. And, as an essential nutrient in human development and disease prevention, zinc saves lives.
The second method is to mine Sphalerite Ore found in the Nether. Uses Zinc Dust can be smelted into Zinc Ingots , which can, in turn, be used in Mixed Metal Ingot production.
In mining applications, it is used for froth flotation of minerals. Zinc sulphate is also used for zinc plating. ... Zinc Dust Zinchem uses a unique designed Zinc Dust plant to produce a range of zinc dust with the highest purity and a controlled particle size. The range complies with ASTM D520 standard.
home Uses Of Zinc Dust In Mining . Recent post. Crawler Mobile Crusher MTW-Z European Trapezium-Mill ... crusher for hire in india a crusher is a machine designed to reduce large rocks into smaller rocks gravel or rock dust the earliest crushers ... Rock Crusher Mining Equipment eBay- used small portable rock crushers for sale,I have been ...
Nov 03, 2020 The Red Dog mine in Alaska operated by Canadas Teck Resources kept its top dog status with zinc production of 552.4kt in 2019, a
Sep 14, 2016 Park states that its effect is to keep the copper in solution allowing only gold and silver to be precipitated but at the Creston Colorada mine in Sonora, Mexico, a system was in vogue, invented by Mr. Higgins, the metallurgist, of precipitating the gold and silver with a minimum of copper, out of the strong and rich solution on ordinary zinc shavings and passing
Mine tailings are large piles of crushed rock that are left over after the minerals of interest such us lead, zinc, copper, silver, gold, etc., have been extracted from the rocks that con- tained them. The extraction process is only partially efficient and, as a result, a percentage of the desired minerals are left behind in the mine tailings.
Mining. Some mines produce zinc as a side-product of some metal that has a higher concentration in the ore. Most zinc mines produce zinc and lead or zinc and nickel. Zinc extraction from zinc blende (ZnS) Over 95% of the worlds zinc is produced from zinc blende (ZnS). 2 Manufacture of Zinc
Lead and Zinc Smelting Industry Description and Practices Lead and zinc can be produced pyrometal-lurgically or hydrometallurgically, depending on the type of ore used as a charge. In the pyromet-allurgical process, ore concentrate containing lead, zinc, or both is fed, in some cases after sin-tering, into a primary smelter. Lead concentra-
Zinc is one of the widely used metal in the entire world. Zinc is mostly used for galvanizing other metals in order to protect them from rusting. Most of it is used in die-casting which are important in automobile electrical and hardware industries. Zinc is found in several ores in the form of zinc blende and calamine. The principal mining ...
Zinc, which is used to protect car bodywork from corrosion, is transferred into the dust when it is recycled. These dusts, containing 15 to 35% zinc, are enriched in a giant rotating furnace using the Waelz process. The Waelz oxides produced are secondary raw materials for zinc producers.
Zinc Dust (Micronized) Zinc Dust with min. 98% metallic zinc content is used in paint, chemical, mining, sherardizing and thermo-diffusion coating industries.
MINING AND CONCENTERATING Zinc ores are obtained by many mining techniques, ranging from open-pit mining to the normal underground methods. ... or the oxides goethite or hematite. This is then followed by cementation with zinc dust to remove other metallic impurities (including copper, nickel, cadmium, cobalt, and germanium) from the solution ...
(2000). Recovery of zinc from electric-arc furnace dust by leaching with aqueous hydrochloric acid, plating of zinc and regeneration of electrolyte. Mineral Processing and Extractive Metallurgy Vol. 109, No. 3, pp. 121-128.
Jun 11, 2020 The zinc and manganese used in the fertilizers were recovered, in the form of mixed metal dust, from single-use, disposable alkaline batteries.
Nov 26, 2015 Although mining is a cornerstone of the South African economy (), it generates copious amounts of dust. 1 The dusts may be toxic since they may also be contaminated with various toxic metals.For this reason, the prevalence and severity of occupational diseases in the mining industry depends on the ores mined, the contaminants present and also on the levels
Nov 02, 2020 Toxic chemicals used in mining include cyanide, sulfuric acid, and solvents for separating minerals from ore. nitric acid. ammonium nitrate and fuel oil (ANFO) used in blasting tunnels. heavy metals such as mercury, uranium, and lead. gasoline, diesel fuel, and exhaust fumes from vehicles and equipment. acetylene for welding and soldering.


WASHINGTON: The sub-committees of the European Parliament and US Congress will be meeting to discuss the situation in Indian-Held Kashmir (IHK).
The US Congress’ Foreign Relations Committee House Sub-Committee on Asia will meet to discuss human rights violations in the IHK. The meeting has been called by Chairperson Brad Sherman.
The European Parliament’s Committee on Foreign Affairs will meet tomorrow (Tuesday) and also discuss Kashmir. AJK Prime Minister Raja Farooq Haider will attend the meeting and speak to the MPs. Both committees will discuss the four-week curfew in IHK and situation in the valley.
Reports coming out of the valley say the Indian government was involved in mass imprisonments and human rights violations. This situation developed after India repealed on August 5 Article 370 of its constitution. Pakistan has been raising the issue on several international platforms, including approaching the UN and Organisation of Islamic Cooperation (OIC).
Prime Minister Imran Khan has also spoken to multiple world leaders and briefed them on the situation in Kashmir. After the UN Security Council the voice of Kashmiri people, who have been living under siege since Aug 5, has now reached the United States Congress. The issue of Kashmir will be discussed at the Foreign Affairs Committee of the US Congress.
The US Congress Asia Sub-Committee will also hear about the atrocities committed by India in IHK. Meanwhile, the residents of Birmingham expressed solidarity with the people of IHK by participating in the ‘Free Kashmir March’ held outside Birmingham City Council House.
Hundreds of people from all walks of life gathered to express solidarity with the oppressed people of IHK. The protesters marched towards the Indian Consulate, Birmingham, raising slogans against Indian Prime Minister Narendra Modi and Indian forces personnel who were brutally killing innocent people in the occupied territory.
The keynote speakers were Deputy Opposition Leader of the British Parliament Tom Watson, MP, leader of the Council, Councillor Ian Ward, MP Liam Byrne, MP Shabana Mahmood, MEP Phil Bennion, Councillors Waseem Zafar, Ranjit Singh, Robert Alden, Sharon Thompson, Muhammad Yaseen, Councillor Zaker Choudhry, President of Tehreek-e-Kashmir UK, Fahim Kayani, and others.
In their speeches, they expressed solidarity with the Kashmiri people and said the Indian government should stop human rights violations in IHK. They said the international community cannot tolerate any human rights violations that may take place anywhere in the world.
Tom Watson condemned the human rights violations by Indian troops in IHK and showed solidarity with the Kashmiri people. He said India must find a solution to the lingering Kashmir dispute.


text: Data Availability StatementThe datasets used or analyzed during the current study are available from your corresponding author upon request. reverse the favorable effect of pcDNA3.1-MEG3 on glioma progression. Conclusion Collectively, the evidence in this study indicated that MEG3 was downregulated in glioma cells and inhibited PGC1A proliferation and migration of glioma cells via regulating miR-6088/SMARCB1 axis. 1. Introduction Glioma, a malignant tumor, is the most common intracranial main malignancy with the highest morbidity and mortality rates worldwide [1C4]. In spite of the great efforts around the clinical development, the long-term prognosis and postoperative outcomes for patients are still far from being acceptable [5, 6]. Moreover, palliative therapies fail to accomplish the desirable therapeutic efficiency in concern of the vague understanding around the potential pathophysiological mechanisms of glioma progression . Therefore, it is of great clinical value to further explore the detailed pathogenic mechanism of glioma progression and therefore to recognize more effective diagnostic strategies and potential healing goals. Long noncoding RNAs (lncRNAs) certainly are a subset of RNAs that go beyond 200 nucleotides long with limited or no protein-coding capability . The dysregulation of lncRNAs in glioma continues to be revealed. For instance, lncRNA MALAT1 enhances the proliferation and activity capability of glioma stem cells and promotes glioma tumorigenesis . LncRNA maternally portrayed gene 3 (MEG3), situated on individual chromosome 14q32.3, is a tumor suppressor gene . Also, a report proved that MEG3 could regulate tumorigenesis through its relationship with microRNA  lncRNA. For instance, lncRNA MEG3 inhibits the tumorigenesis of hemangioma through sponging miR-494 and mediating PTEN/PI3K/AKT pathway . Nevertheless, the assignments of lncRNA MEG3 in glioma advancement and its own molecular systems remain unclear. SMARCB1 is recognized as INI1 also, whose downregulation is certainly associated with intense behavior of glioblastoma . Also, a written report has uncovered that SMARCB1 straight blocks transcription of glioma-associated oncogene homologue (GLI), thus lowering the downstream hedgehog pathway focus MLN4924 on genes like GL1, GL2, and protein patched homologue 1 . However, it remains to be explored whether SMARCB1 implicated in the proliferation and migration of glioma cells. In this work, we found downregulated MEG3 and SMARCB1 in glioma cells, but no direct conversation of MEG3 and SMARCB1 was recognized. Therefore, we aim to explore the possible role of MEG3 and SMARCB1 in glioma cells and to further clarify the mechanism herein. The application of dual-luciferase reporter gene assay and gain and loss of function found that MEG3 serves in glioma cells as a competitive endogenous RNA (ceRNA). Altogether, the MLN4924 potential mechanism herein is usually that MEG3 negatively targets miR-6088 to regulate SMARCB, thus mediating the proliferation and migration MLN4924 of glioma cells. 2. Materials and Methods 2.1. Cell Culture Normal human astrocytes (NHA) and human glioblastoma U251 and U87 cells purchased from your American Type Culture Collection (ATCC) cell lender were managed in DMEM (Thermo Fisher Scientific, Wilmington, DE, USA) with 10% Fetal Bovine Serum (FBS) (Thermo Fisher Scientific, Wilmington, DE, USA) and cultured in a humid atmosphere of 5% CO2 at 37C. 2.2. Cell Transfection U251 and U87 cells in logarithmic phase were transfected with 2 ug of pcDNA3.1, pcDNA3.1-MEG3, si-NC, si-MEG3, pcDNA3.1-SMARCB1, si-MEG3, 100?nM mimic NC, miR-6088 mimic, inhibitor NC, or miR-6088 inhibitor plasmids (RiboBio Co., Ltd, Guangzhou, China) and correspondingly grouped into pcDNA3.1 group, pcDNA3.1-MEG3 group, si-NC group, si-MEG3 group, pcDNA3.1-SMARCB1 group, si-SMARCB1 group, mimic NC group, miR-6088 mimic group, inhibitor NC group, miR-6088 inhibitor group, si-MEG3?+?inhibitor NC group, si-MEG3?+?miR-6088 inhibitor group, si-MEG3?+?pcDNA3.1 group, and si-MEG3?+?pcDNA3.1-SMARCB1 group. All transfections were performed in rigid accordance with Lipofectamine 2000 reagent instructions (Thermo Fisher Scientific, MA, USA). The transfected cells were cultured with serum-free DMEM and incubated in 5% CO2 at 37C.


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BRIAN Laundrie’s remains were identified exactly one month after his fiance Gabby Petito’s remains were as well, spurring plenty of internet discussion on the already eerie case.
The FBI confirmed the remains found at the Carlton Reserve in Florida on Wednesday belonged to 23-year-old fugitive Laundrie, repeating an almost exact sequence of events that occurred a month earlier when Petito’s body was found and then identified.
Matching dental records to the remains found near a swamp in the Carlton Reserve on Wednesday, the FBI confirmed Laundrie’s death to his parents on Thursday evening – after his parents discovered his belongings at the reserve.
The bizarre coincidence followed the events of how Petito’s remains were found and subsequently identified a month earlier.
On September 19, Petito’s remains were found in Grand Teton National Park that were “consistent with the description of Petito” according to the FBI.
The uncanny find sparked a number of internet sleuths to express shock at the correlation of events.
“It’s weird they happen to find him almost exact one month from when Gabby was found,” wrote one user on Twitter.
Others expressed concern with how Laundrie’s parents were at the location after a month of not cooperating with authorities and were able to locate Laundrie’s belongings and remains.
“They wait a month to do look and happened to go right to him Immediately. Nope. They do need to be charged. & had they told the truth & cared an Gabby, instead of camping, he’d be alive,” wrote another user.
Laundrie’s parents on Wednesday arrived at the reserve at 7AM after their lawyer Steven Bertolino informed authorities the reserve was now open to the public and they were going to search for their son.
Upon their arrival, Laundrie’s dad Chris found a bag containing belongings of Brian.
On the other side of the train, two officers found a backpack of Brian’s not that far away from the swamp where his remains were later discovered.
Laundrie’s parents have not yet commented after the FBI confirmed their son’s death on Thursday.
However, their lawyer said they are still processing the sequence of events.
“There are two young people that have now lost their lives,” Bertolino said during an interview with NBC News following the grim discovery.
“These are parents that are suffering.”
“Now, I understand that whatever happened or whatever didn’t happen… This is tragic for two families.
“And anybody with a child, and anybody with a sense of humanity can understand the frustration that both families feel on that point.”
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Todd Bowles expects Jets QB Ryan Fitzpatrick to play at least two quarters of football in Saturday night's MetLife Bowl against the Giants, as the third preseason game is generally known as the last dress rehearsal for the starters prior to the regular season. In Wednesday's media availability, the head coach said Geno Smith will be the second QB to play against the Giants.
"You have to look at it all the same because you don't want to have a letdown, you don't want to have a mental letdown. It's all the same for me," Smith said after Wednesday's practice. "Every single rep counts, every single minute or rep you get in a game counts. You always have to have that mentality, so things don't change no matter what the situation is."
Smith, who is entering his fourth season with the Green & White, has thrown for a total of 126 yards along with a touchdown and an interception in two preseason games.
"It's really no different. I'm just continuing to work hard and preparing the same way," he said. "It's just going out there, executing and make the right reads."
Bowles did not reveal his plans about how much playing time, if any, QB's Bryce Petty and Christian Hackenberg would get in the second half.

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