One year after acquiring a new helipad, the Elkford Fire Department says it has been a huge asset to the community of Elkford.
Emergency responders have deemed it a successful means of helping those who are in dire need of a medical extraction.
“Since it’s been established and operational, we’ve used it a number of times. In each of those times, we’ve had some successful outcomes with people that have been critically injured,” said District of Elkford director of fire rescue and emergency services, Corey Kortmeyer.
Kortmeyer said that if the helipad was not in the community, it might have had negative impacts for those people who have needed air transportation to higher care centres in Calgary.
“Calgary, as the crow flies, it’s only 45 minutes for them to get to us,” continued Kortmeyer.
“So when we’re dealing with some critical care people like we have had in the past, it’s absolutely a breath of fresh air to have these people come in quickly, dust in, grab who they need to grab and get them to higher care as quick as they can.”
Previously, there was a helipad located behind Elkford’s medical clinic, but there were a number of issues with it and it was therefore deemed unsafe by Navigations (NAV) Canada.
After the old pad was deactivated and before the new one was built, emergency trauma teams were forced to land aircraft in the high school field, and elsewhere, on multiple occasions.
At this point, the District knew that a permanent landing structure was needed. The District proposed that a new pad be built behind the Elkford Fire Hall and NAV Canada approved.
In November of last year, The Free Press reported on the grand opening of the new helipad, a $273,371 project funded by Teck, Columbia Basin Trust and the Bearspaw Community First Foundation. Through the charity golf tournament alone, $95,000 was raised for the project.
The Elkford Fire Department has been kept on its toes throughout November, which has been busier for calls than usual. However, they are aided by their strong team of 30 volunteer and paid-on-call firefighters.
“We’re absolutely blessed,” said Kortmeyer. “I can say that we got just under 30 volunteers, paid-on-call volunteers, that are very dedicated to this family of Elkford Fire Rescue, and the community as well. They make my job easy.
“We have an amazing group of people that have dedicated a large portion of their daily activities to making sure that if you do have a bad day, they’re around to make it better.”
On December 24, the fire department will be driving around their Christmas-light-decorated fire truck, ensuring Santa makes his way from one side of the town to the other, safely.


text:
Our apartments are located in Agia Galini, a village not far away from Rethymno, located in south Crete. Our design philosophy is simple lines, bright white earth tones and natural materials with respect and faithfully serve is our simplicity. Minimal chic design and bohemian atmosphere accord to your comfort and total relaxation. The room facilities cater to the needs of the modern traveler, who wants to be themselves, authentic and simple.
It is our top floor apartment built in 2014, wide windows in front allow to enjoy the panoramic view, spacious terrace include sunbeds. The walls are stone decorate and a large room closet can accomodate all your clothing and more, our bathroom includes a Hot Tub (jacuzzi).
In the heart of the fishermen village and perched on a cliff side overlooking the sea, this traditional house has been fully renovated in 2019, combining modernity and authenticity. Stone and white coloured, this small property consists in : - A 40sqm minimalist interior : fitted kitchen opened on living room with a sofa ((convertible to a real double bed), bathroom, separate toilet, and an elegant small bedroom with sea view 3 terraces with breathtaking views : pergola, solarium, micro-pool, …

domain: design


text:
Among all the nutrients required for the body, vitamin B12 is essential when it comes to supporting bone health, the formation of red blood cells, boosting energy levels, and more. To overcome B12 deficiency, have these five fruits and vegetables.
Having a balanced diet rich in essential minerals, nutrients, and vitamins is very important for a fit and healthy lifestyle. From calcium to magnesium, from vitamin C to vitamin A, there are several nutrients that the human body requires for proper functioning. One crucial vitamin for overall health is vitamin B12. Vitamin B12 has many roles to play in the body. It supports the normal functioning of nerve cells, red blood cell formation, and DNA synthesis. It also boosts energy and improves memory.
So, if you have a B12 deficiency, include these 5 fruits and vegetables in your diet.
Video credits: Saaol Heart Care/YouTube
Mushrooms are an excellent source of B12. Not just vitamin B12, this fungus type also contains vitamin D, calcium, protein, copper, niacin, phosphorus, germanium, potassium, and others. If you are suffering from a B12 deficiency, you must include mushrooms in your diet. Right from putting it as a topping to your pizza to adding it in salads, there are numerous ways to have mushrooms.
This humble fruit has high nutritional value and can do wonders for the body. Rich in fiber and so many other essential nutrients, bananas also contain vitamin B12. Did you know that bananas can help in weight loss too? Yes, only if consumed in the right manner.
Potatoes are one of the most consumed and versatile vegetables. The uniqueness of potatoes is that they adjust with every single vegetable and perfectly complement it when it comes to consistency as well as taste. Among the many minerals and nutrients that potatoes contain, vitamin B12 is what we should talk about. Potatoes are easy to deal with and could be transformed into so many dishes.
There is no denying that an apple a day keeps a doctor away. Thanks to their high nutritional value, apples could be a boon for human health. From boosting healthy skin to supporting weight loss, apples can do it all. Did you know that apples also contain vitamin B12? So, don’t wait and start including apples in your diet.
Blueberries contain several antioxidants that provide healthy skin, support weight loss, cure diabetes, remove stress, and even prevent diabetes. Blueberries are one of the fruits that contain high levels of vitamin B12. It contains other vitamins and minerals too that are required for the body.
So, if you want to overcome the deficiency of vitamin B12 in your body, have these fruits and vegetables. However, one must consult a doctor in case of any severe illness or allergy. Taking a doctor’s advice before jumping to a conclusion is always a good idea.

domain: biology


text:
SEALED Vintage CHRISTMAS Songs HOLIDAY Vinyl Ep 7" 45rpm Anne Lloyd And the Sandpipers Wonderland wdp2093 Record White Christmas Santa Claus
Read the full title SEALED Vintage CHRISTMAS Songs HOLIDAY Vinyl Ep 7" 45rpm Anne Lloyd And the Sandpipers Wonderland wdp2093 Record White Christmas Santa Claus
Christmas Songs - a 4 Song Xmas Holiday Christmas Record
by Anne Lloyd + the Sandpipers with Mitch Miller And Orchestra
Factory SEALED Vintage Copy in perfect MINT condition!
a dead-stock (old unsold store stock) copy we got from an
old-school record shop nearby us that recently closed and lots
of great old stock like came out of the woodworks. maybe
this is from your childhood? it's long out-of-print and it's
not too often something turns up like this sealed!
this is a 7" 45rpm EP Vinyl Record in Picture Sleeve Cover
and it'd make for a nice addition to any record collection, especially
for a collector of Holiday and Christmas Music / Songs. it'd also be
great for a jukebox owner who wants songs for the holidays.
Anne Lloyd And The Sandpipers
With Mitch Miller And Orchestra – Christmas Songs
Label: Wonderland Records (7) – WDP 2093
Format: Vinyl, 7", 45 RPM, EP
Country: US / Released: 1966
Genre: Pop, Children's / Style: Holiday Christmas Songs
A1 Santa Claus Is Coming To Town
A2 Cracker Jack Christmas
B1 White Christmas
B2 The Night Before Christmas
Wonderland Double Play / Extended Play Record.
from our huge inventory of New + Used Vinyl LP Records
feel free to write if you're looking for a specific LP, 33.3, 45 or 78 rpm Record.
What Cheer Records + Vintage
North Providence, Rhode Island USA
There was a problem calculating your shipping. Please try again.
407 shop reviews5 out of 5 stars
great transaction. thank you!! :)
First, Chris & Jennifer went ABOVE AND BEYOND to get this to me in time to give it to my husband for Christmas!! Second, this album is in PERFECT CONDITION, still sealed in the original packaging. *We grew up singing these songs with the television animated program, and my husband sometimes sings them (ex: “...number eight ... it’s a zero that turns round upon itself”). Thank you, Chris and Jennifer! This meant so much to both of us!! - Kim 💕
So excited to hang my print up!! I also enjoyed the stickers by local artists that came along with it. Thank you so much!
Item shipped out quickly and arrived just as described; A+ seller!Happy to add this movie to my VHS collection!
Photos from reviews
Vintage SEALED the Twelve Days of CHRISTMAS Holiday Vinyl Ep 7" 45 SANDPIPER Chorus Wonderland 2090 Record wdp2090 xmas Little Drummer Boy
Vintage SEALED Best Loved CHRISTMAS CAROLS Holiday Vinyl Ep 7" 45 the Sandpiper Chorus Mitch Miller Wonderland wdp 2091 Record wdp2091 xmas
Vintage SEALED the CHRISTMAS Song CHESTNUTS Roasting Holiday Vinyl Ep 7" 45 Sandpiper Chorus Wonderland 2088 Record wdp2088 Xmas Music Songs
Sealed Vintage RAGGEDY ANN & Andy CHRISTMAS Fun Book 1981 Holiday Vinyl Ep 7" Record xMas Kid Stuff KsR 971 KSR971
$20.00 FREE shipping

domain: artistic


text:
Paul Wandtke Confirms He's Exited TRIVIUM, New Touring Drummer Announced
The saga of Trivium's mysterious drummer situation continues on, though this time we've actually got answers! According ex-Trivium drummer Paul Wandtke's website, he's officially exited the band in pursuit of a new band called Bedlem.
Paul Wandtke (Trivium’s former “touring powerhouse”) has a launched a new band in Chicago called Bedlem, their debut single “Triumph” will be released in February. Visit www.bedlemofficial.com for more info
Footage of Paul Wandtke tracking drums at Uptown Studios in Chicago, IL for his own original project Bedlem.
Guess the rumors were true, check out my new band "Bedlem" https://t.co/vzvJwMOkRB
— Paul Wandtke (@paulwandtke) January 20, 2017
Wadntke is also aware of Matt Heafy's statement that the last three Trivium drummers were just "session players," and he says he knew that coming into the band in an interview with Rock Feed.
"I was the first Trivium drummer in over ten years to get some press in magazines, like Modern Drummer. And that is a true statement, that Matt Heafy did say that [about me being what Trivium had always been always missing]. But bottom line, I did come into it in a work-for-hire situation. It makes sense to me what they were doing. If it was my band, I would have done the same thing, because you're taking on a stranger."
It shouldn't come as much of a surprise either that Alex Bent (ex-Battlecross, Brain Drill, etc.) is Trivium's new touring drummer, as confirmed by bassist Paolo Gregoletto.
So as to who is playing for us in the UK/EU…
— Paolo Gregoletto (@TriviumPaolo) January 23, 2017

domain: news


Kingman Government Criminal Cyberattack Update
*Ongoing Forensic Investigation*
KINGMAN, Ariz. – At this time, the city is working toward finding whether or not any data has been compromised. More ongoing forensic investigation will determine and conclude if any information was compromised, at this time the city is hoping the next process moves quickly, however we do not have a timeline at this point. The city completed a preliminary review and did not locate any compromised confidential information. In an overabundance of caution, the city will perform a more systemic review to ensure that no confidential information was compromised. City leadership appreciates the patience and understanding of our internal team members and external customers as we understand this is a lengthy process.
The city is insured against this type of criminal cyberattack, and we are working closely with different agencies and an insurance provider to conduct the forensic investigation. At this time, the city is still working to discover the extent of the event. The city has a legal obligation to inform any customers or internal team members if their information has been damaged or exposed. The forensic investigation into the discovery of exposed data is a huge undertaking, as there is an immense amount of data to be analyzed.
Although certain emails may seem legitimate at first glance, it is more important than ever for people to be vigilant regarding emails they receive, because criminal cyberattacks can attack individuals, cities, and also large corporations. The city is still working on the investigation and we will keep updating residents as information becomes available.
The City of Kingman government operations are close to fully operational after the February cyberattack. The City of Kingman is categorizing this as a criminal cyberattack; the city never lost control of our network.


text:
Donate Your Car — It's Simple!
Step 1: Print and complete the donation form.
Step 2: Once we receive your donation form, we will arrange for a tow.
Step 3: A tax form will be sent to you 30-45 days after your doantion.
Download the Car Donation Form
Download information regarding Fast Track Titles
Download the IRS Vehicle Donation Guide

domain: finance


text:
In the vibrant city of Brisbane, where the sunshine meets a cosmopolitan lifestyle, the quest for beauty and self-enhancement has found a haven in the form of cosmetic clinics. cosmetic clinic brisbane have become synonymous with innovation, expertise, and a commitment to helping individuals achieve their aesthetic goals. In this blog, we will explore the dynamic world of cosmetic clinics in Brisbane, delving into the services offered, the latest trends, and the top clinics that have garnered acclaim for their transformative work.
The Rise of Cosmetic Clinics in Brisbane:
Brisbane has witnessed a surge in the popularity of cosmetic procedures in recent years, and this phenomenon can be attributed to the increasing awareness and acceptance of aesthetic treatments. With a diverse population that values self-care and well-being, Brisbane’s cosmetic clinics have become sought-after destinations for those looking to enhance their natural beauty.
Cosmetic clinics in Brisbane offer a wide range of services designed to address various aesthetic concerns. From non-surgical treatments like injectables, dermal fillers, and laser therapies to surgical procedures such as facelifts, rhinoplasty, and breast augmentation, these clinics cater to a broad spectrum of client needs. Many clinics also provide comprehensive skin care regimens, ensuring that clients receive personalized care for their unique skin types and concerns.
Expertise and Innovation:
One of the key factors contributing to the success of cosmetic clinics in Brisbane is the expertise of the practitioners. Brisbane boasts a pool of highly skilled and qualified cosmetic surgeons, dermatologists, and aesthetic nurses who stay abreast of the latest advancements in the field. The commitment to innovation is reflected in the use of cutting-edge technologies and techniques, ensuring that clients receive safe and effective treatments.
Top Cosmetic Clinics in Brisbane:
- Esteem Medi Spa: Esteem Medi Spa has earned a stellar reputation for its comprehensive range of cosmetic treatments. With a team of experienced practitioners, they specialize in both non-surgical and surgical procedures, providing clients with personalized and natural-looking results.
- The Cosmetic Medicine Centre: Known for its commitment to excellence, The Cosmetic Medicine Centre offers a diverse array of treatments, including injectables, laser therapies, and surgical procedures. The clinic is renowned for its focus on delivering results that enhance and rejuvenate without compromising a natural appearance.
- Ashbury Cosmetic Clinic: Ashbury Cosmetic Clinic is celebrated for its holistic approach to beauty and well-being. Their team of skilled professionals provides a range of services, from anti-wrinkle injections to body contouring, with an emphasis on achieving harmony and balance.
In Brisbane, cosmetic clinics have become instrumental in helping individuals achieve their desired aesthetic outcomes. With a perfect blend of expertise, innovation, and personalized care, these clinics have transformed the landscape of beauty and self-enhancement in the city. As the demand for cosmetic procedures continues to rise, Brisbane’s cosmetic clinics remain at the forefront, empowering individuals to look and feel their best in the pursuit of confidence and beauty.

domain: health


text:
Arthur Jacks sold to property investor
20th July 2020
This wonderful restaurant premises in Forfar, Angus has been sold by Bruce & Co.
Acquired by the vendor in 2014 and thoughtfully refurbished in 2015, the restaurant premises of Arthur Jacks presented an excellent opportunity for a prospective buyer to introduce an ideally located licence & leisure property to their portfolio.
Situated in the county town of Forfar, Arthur Jacks occupies the ground floor of a commanding end-terraced property. The premises benefits from a large degree of repeat custom from the local residential areas, as well as attracting customers from the neighbouring towns and villages.
Constituting the ground floor is a sleek bar and lounge area, lying across from the first of 2 dining areas. This dining location houses a total of 28 covers with stylish wooden chairs and tables, offering an open and airy atmosphere for patrons. Further within the property lies the second dining area with enough seating for an additional 24 covers, as well as the fully equipped commercial kitchen and storage area. The building also contains toilet facilities and a basement for storage.
Seeking retirement from the licenced trade, Brian Nicol made the decision to market the premises and formally instructed Bruce & Co to facilitate the sale, recognising the benefit of using the market leading brokerage for Scottish licenced and leisure.
Following an extensive marketing campaign, generating 2 offers, the premises were sold to property investor David Shepherd, who now plans on leasing out the property to an aspiring restauranteur.
Brian Nicol commented on the sale;
“I was delighted with the sale I made through Bruce & Co. Stephen Croft was the negotiator dealing with the transaction and he kept in touch with me on a regular basis and worked hard to seal a deal for me. He showed that he was passionate about his work and I would highly recommend the services of the team at Bruce & Co, who helped navigate a difficult time during lockdown.”
David Shepherd commented on purchase of Arthur Jacks;
“Stephen was diligent throughout the process and I was delighted to become the new owner. Thanks to Bruce & Co for helping through this transaction.”
Lead negotiator Stephen Croft from Bruce & Co commented;
“I was delighted to hear that the sale of Arthur Jacks was completed. I wish our client and the new owners the best for the future.”

domain: economics


text:
"Efficient and well organised"
About: Fleet Community Hospital Fleet Community Hospital Fleet GU51 4LZ
Posted via NHS Choices
Brought my 90-year old mother in for an orthopedic follow-up. Parking was easy, reception staff helpfully pointed me to a wheelchair and out-patients team had everything under control. Appointment time has bang on (actually slightly early) and the consultant surgeon we met was clear, honest and practical. Overall, a refreshingly positive NHS experience.

domain: medical


text:
In Ireland where our own constituition enshrines such edicts as "Mothers shall not be obliged _ _ _ _ _ to engage in labour to the neglect of therir duties in the home", the battle for abortion rights can seem like a mamouth up hill struggle. However what makes our fight even more difficult is the current onslaught which womens rights, in particular abortion rights are experiencing internationally. Even in those countries where limited abortion rights have been won they are now under constant attack.
In America the supreme court recently voted by 5 judges to 4 to enforce a restrictive Pennsylavania law which requires a mandatory waiting period foe women seeking abortions and forces teenagers to inform their parents of their intentions to have an abortion. The ruling was greeted with the headline in Village Voice "Court to women : Drop Dead". This ruling will only result in adding pressure to already frightened pregnant young teenaged girls. It also only further removes working class women from the rignht to abortion by increasing the ecomomic difficulties by having an enfoced waiting period. Many women cannot afford to take weeks of work in order to have one of the worlds safest operations.
Almost since the 'Roe Versus Wade' decision which legalized abortion in America in 1973; this basic right of women to control their own fertility has been under attack. In 1978 the Hyde ammendment deneyed the funding of abortion on the Federal Medicaid (like NHS). In 1984 Regan Administration forced a ban on funding to International Organisiations who counsell women on abortions. This does not help to alleviate the problem of an estimated 200,000 women dying in back street abotions every year. The drug RU-486 is still banned in America even though it would enable women to have safe abortions enduced at home. In America a doctor may refuse to treat a women, all he has to do by law is refer the woman to another Doctor. However the fight against abortion has not just been a legal one.
It is one of the great paradoxes of our time that the 'Right to Life' campaign can encompass such groups as "Operation Resuce" who specialize in terroizing women, staff and Doctors of the clinics.
Attacks ranging from bomb scares to sabotage and fire bombings. Even the odd Death Threat to Abotion Activists is not uncommon. In 1985 a private Clinic in Massachusettes said they would not be performing Abortions dus to "Acts of terrorism around the country and the constant harassment of our patients and ourselves have forced us to make this decision". Jan 18 1985
A bo0md scare at Manhattan Eastern Womens Hospital forced an evacuation of staff and women out into the street, many patients still groggy form pr-op anesthetic. Bill Baird an abortion activist has had threats on his life and his clinic on Long Island NY was fire bombed as early as 1979 . In 1984 a clinic in Pesacola, Florida was fire bombed over Christmas and the perpetrators claimed "It was a gift to Jesus on his birthday". In 1943 Hitler made abortion a crime punishable by death, it strikes me that there may be a number of people in the "Right to Life" campaign who may agree, given that the bombing of clinics is now one of their tactics.
In German law paragraph 218 permits abortion when there are 'indications of serious need' for medical or social reasons (poverty excluded) ans only in the first 12 weeks of pregnancy. This type of restrictive law is one we must avoid in Ireland. In 1988 Dr Horst Theissen went on trial for performong Illegal Outpatient Abortions. He faced a minimim of 15 years in prison & disbarement from his profession if convicted. His "Crime" was to charge patients $130 to $270 for abortions , consultations, examinations and post-opertaion check ups. The state prosecutor admitted that "Poor women were treated free" by Dr Theissen. When asked why he broke the law the Dr replied that he "accepted the risk because he considered it unworthy, humilating and medically irresponsible to submit to medievalist laws". Previously that year two Nuremburg Gynacelogists were convicted on abortion counts one getting four years in prison. In Bavaria due to the counselling laws women have to meet Doctors, Counselors, Health officials Clergymen and Physciatrists before they will certify serious need for abortion. This is a further indication of how we have to make sure that the decision to terminate a pregnancy is left to the women herself and not a plethora of counsellors.
Recently in Birtain the House of Parliament voted on regulating what research could and could not be carried out on embryonic of fetal matieral. This is the first step on the murky path which leads to the ridiculous laws giving legal rights to the foetus. Already anti-abotionists are asking if the embryo has legal rights at 15 days how can it be aborted at 15 weeks. These arguments are being used to erode the limited abortion rights secured in 1967 Abortion Act. This Act allows termination of the pregnacny when it occurs in 'unsuitable circumstances'. This can be defined when two doctors must be convinced that giving brith will demage the womans of the childs physical or mental health. The law was also delibrately vague about facilities so that local health authorities were implementing the NHS cuts in the Gynacelogy Departments and some hosptals will refuse to carry out an abortion after the 12 week. Although the law initially specified up to 28 weeks recent moves have tried to limit this to 24. However it is getting increasingly difficult to find a clinic which will perform the operation after 20 weeks ( 7 Clinics in Britain ) and none after 24 weeks. These are all indications of the constant erosion of the rights won in the 1967 act. The situation in Britain leaves the Women concerned unacceptably at the mercy of MP's, Health Cuts, and didatic Doctors who continue to impose restrictions on what should be the womens decision.
In France there have been a number of recent 'Commando' like raids on clinics. In Lourde (Surprise, Surprise) on the 5th May this year a self style 'commando' tried to block the enterance of women to a clinic. At Nimes some person entered the clinic and prevented operations being performed that day. "SOS Babies" another crack oufit, invaded the clinic in Colombes near Paris, their Leader on Xavier Dos becomes over-excited and injures a woman in the process. A second attakc occured in the Pau clinic by "Operation Resuce" resulting in damage to equipment but there was a swift reply by the local collective for abortion rights (including women form the Federation of Anarchists). As you are aware the number of incidents like the ones I have already listed are becoming more prevalent as this issue is one again becomes the Battlefield for the attackers and defenders of Womens Rights.
The abortion issue is now a part of the Presidental election campaign in America with Clinton paying lip service to the freedom of choice and he has the backing of the National Orgainisiation of Women and the National Abortion Rights League (who's Chairwomen Kate Michleman is now a full time member of his campaign). However the Democrats Freedom of Choice act which they promise to introduce if they win the election will be diluted to pander to their more reactionary constituencies.
Historically it is important to remember that in 1973 the supreme court (under the nixon appointed Cheif Justice - Warren Burger) gave limited abortion rights as a concession to the newly formed Feminist movemnet and the radicalised youth of that time.
Only by getting people involved in social struggle and by being visible on the streets was any victory won. It is further proof (as if any were needed) that public movements determine political outlooks. Politicians are only as good or as bad as the last opinion pole they read. Yet, despite this NARL and NOW are both firmly behong Govenor Clintons campaign oblivious to the fact that in ARKANSAS (his home State) has one of the most invidious abortion laws.
As we observe the gradual and direct way that the right is stealing back the limited gains won by Women in America, Britain, and Germany we must pursue a very Active , Direct Campaign to win Abortion in this country. We must seek Free, Legal, Safe Abortion on DEMAND in Ireland because if we leave any gaps in our demands these will be exploited in order to impose further restrictions in teh future. We have to be aware and safe guard gainst the backlash which we are now observing internationally.
In the words of one man in America teh recent judgements didn't kill the 'Roe V Wade' Ruling " it gave the states permission to strangle it to death with REd TAPE ". When we win a victory for womens rights in this country lwt us make sure it is a permanent one safe from the hands of the beaurcratic stranglers. Let us make sure that the fundamental right of the woman to choose to have an abortiuon is her decision alone.
As Anarchists we recognise the fight for Abortion Rights as a class issue. Women have to be freed from the role of ' Homemaker' so that they can take up their righful place in society. They must have to freedom to choose when to have or not to have children. The ruling class use the idealogy of women playing teh centeral role in "Family Life" as a way to ensure less women look for work outside the home, in a time when they fail miserably to provide jobs. We in the WSM see Abortion as only one of the many obstacles which have to be overcome in order to gain some basic rights for women. Free creche facilities must be provided at workplaces, free readily availiable contraception, equal pay must finally be implemented. These rights along with abortion rights are on;ly a tep towards what amounts to human rights. It seems that under capitalism even the most basic of rights have to be fought for when they don't benefit the bosses.

domain: politics


text:
Hello! It's Tracy here with my card using the Crossing Lines, Out of this World, and Wish BIG sets. I just love how the new Out of this World set coordinates with the Crossing Lines set to create your own background!
Hi Dana here!! I played with lots of twine and lots of cute birdies from the Lighter Then Air stamp set! I also used Birds of a Feather for my sentiments (inside i stamped Happy Bird-day!
Hello, happy saturday!It's Sabine.For my card I used two of the adorable new sets : Tada and Now you see Me (the mini, free when you spend 40$)!
How adorable is the little bunny!? I colored him lightly and popped him up.

domain: hobby


text:
Giving a Short General Description of Nizoral: An Antifungal Medication
Nizoral is a highly effective antifungal medication used to treat a wide range of fungal infections in different parts of the body. It contains the active ingredient ketoconazole, which plays a crucial role in inhibiting fungal growth and preventing the production of essential fungal cell components.
Here are key points about Nizoral:
- Nizoral is an antifungal medication used to treat various fungal infections.
- It contains the active ingredient ketoconazole.
- Ketoconazole works by inhibiting fungal growth and preventing the production of essential fungal cell components.
By targeting the growth and integrity of fungal cells, Nizoral effectively fights against fungal infections, providing relief to those suffering from such conditions.
To learn more about Nizoral and its mechanism of action, consult this source.
Exploring the Variety in Antifungal Medications
Antifungal medications come in various forms and are used to treat a wide range of fungal infections. These medications provide options for different types of fungal infections, ensuring effective treatment for individuals. The following are the different forms of antifungal medications:
1. Topical Creams
Topical creams are applied directly to the skin to treat fungal infections on the surface. They provide localized treatment, targeting the affected area. Nizoral, a commonly used antifungal medication, is available in topical cream form, allowing for easy application and effective treatment.
2. Oral Tablets
Oral tablets are taken by mouth and are absorbed into the bloodstream to treat systemic fungal infections. These medications are suitable for treating infections that affect internal organs or large areas of the body. Nizoral is also available in oral tablet form, providing a convenient option for systemic fungal infections.
3. Intravenous Injections
Intravenous (IV) injections involve the administration of antifungal medications directly into the bloodstream through a vein. This method is typically used for severe or life-threatening fungal infections that require immediate and concentrated treatment. IV antifungal medications are commonly used in hospitals under medical supervision.
Shampoos containing antifungal medication are specifically designed to treat fungal infections of the scalp, such as seborrheic dermatitis and dandruff. Nizoral shampoo, which contains the active ingredient ketoconazole, targets underlying fungal infections and effectively improves scalp conditions such as inflammation and redness.
By offering multiple forms of antifungal medications, healthcare providers can select the most appropriate option for each fungal infection, ensuring optimal treatment outcomes.
Mechanism of Action: How Nizoral Works to Treat Fungal Infections
Fungal infections can affect different parts of the body, from the skin to the nails and even internal organs. Nizoral, an antifungal medication, is specifically designed to target and eliminate these infections. Understanding how Nizoral works can help you appreciate its effectiveness in treating fungal conditions.
Nizoral contains a powerful active ingredient called ketoconazole, which plays a crucial role in inhibiting fungal growth and eradicating the infection. Ketoconazole works by interfering with the production of ergosterol, an essential component of fungal cell membranes.
Here are the key steps in the mechanism of action of Nizoral:
- Inhibiting Ergosterol Synthesis: When Nizoral is administered, ketoconazole inhibits an enzyme called lanosterol 14α-demethylase. This enzyme is responsible for converting lanosterol into ergosterol, a key component of fungal cell membranes. By hindering this conversion, Nizoral disrupts the integrity of the fungal cell membranes.
- Impairing Fungal Cell Function: Without sufficient ergosterol, the fungal cell membranes become weakened and their permeability is compromised. This impairment affects the normal functioning of the fungal cells, leading to their dysfunction and eventual death.
- Eradicating the Infection: As Nizoral continues to disrupt the fungal cell membranes and hinder their normal functioning, the fungal cells become increasingly vulnerable and unable to sustain themselves. This ultimately results in the elimination of the fungal infection.
The mechanism of action of Nizoral is highly effective in treating fungal infections, regardless of the affected area. By targeting the synthesis of ergosterol and impairing fungal cell function, Nizoral directly confronts the root cause of the infection, providing relief and promoting healing.
It is important to note that Nizoral is available in both topical and oral forms. Topical application allows for direct absorption through the skin, ensuring targeted treatment of localized infections. Oral administration, however, involves metabolism in the liver, which may affect the drug’s absorption rate and bioavailability. Therefore, the choice of administration should be based on the specific needs of the infection and the recommendation of a healthcare professional.
Understanding the mechanism of action of Nizoral sheds light on its effectiveness as an antifungal medication. By inhibiting ergosterol synthesis and impairing fungal cell function, Nizoral effectively treats various fungal infections and provides relief from associated symptoms.
How does the drug’s absorption rate vary with different forms of administration?
When it comes to the absorption rate of Nizoral, it can vary depending on the form of administration. Here is a breakdown of the absorption rates for different forms of Nizoral:
- Nizoral tablets are taken orally and are metabolized in the liver.
- This metabolism process can result in lower bioavailability compared to other forms of administration.
- It is important to follow the prescribed dosage and take the tablets with a meal to enhance absorption.
- Nizoral is available in the form of topical creams for localized application.
- When applied to the skin, Nizoral is directly absorbed through the skin barrier.
- This direct absorption allows for potentially higher localized concentrations of the medication.
- Intravenous administration of Nizoral bypasses the digestive system.
- This allows for a quicker onset of action compared to oral administration.
- Nizoral injections are usually reserved for severe systemic fungal infections.
- Nizoral shampoo is primarily used for fungal infections of the scalp and related conditions such as seborrheic dermatitis and dandruff.
- When applied topically to the scalp, Nizoral shampoo effectively targets the underlying fungal infections and provides relief from symptoms such as inflammation and redness.
- After applying the shampoo, it is important to leave it on for a few minutes before rinsing to allow for optimal absorption of the medication.
It is worth noting that the absorption rate may be influenced by factors such as the individual’s metabolic rate, overall health, and the presence of other medications.
For more detailed information on the absorption of Nizoral and other antifungal medications, you can refer to authoritative sources such as:
Before making any changes to your medication regimen, it is important to consult with a healthcare professional.
Understanding Antifungal Drug Categories
Antifungal medications play a crucial role in treating a wide range of fungal infections. These drugs can be classified into different categories based on their mechanism of action. Understanding these categories is essential in selecting the most appropriate antifungal medication for a particular infection.
Azole antifungals, including Nizoral, belong to one of the major categories. Azoles work by inhibiting the synthesis of ergosterol, a crucial component of fungal cell membranes. By disrupting the integrity and function of these cells, azole antifungals effectively combat the growth of fungi. Other common examples of azole antifungals include fluconazole and itraconazole.
Polyene antifungals, such as amphotericin B, are another important category of antifungal medications. They work by binding to ergosterol in fungal cell membranes, causing damage and leading to cell death. These medications are often used to treat severe systemic fungal infections.
Allylamines, like terbinafine, have a fungicidal effect by inhibiting an enzyme called squalene epoxidase. This enzyme plays a crucial role in fungal cell membrane synthesis. Without a functional cell membrane, the fungi cannot survive. These antifungals are commonly used to treat dermatophyte infections, such as athlete’s foot and nail fungus.
Echinocandins, such as caspofungin and micafungin, are a relatively newer class of antifungal medications. They work by inhibiting the synthesis of beta-glucan, an essential component of fungal cell walls. Without beta-glucan, the integrity of the fungal cell wall is compromised, leading to cell death. Echinocandins are often used to treat invasive fungal infections, particularly those caused by Candida species.
It’s important to note that the choice of antifungal medication depends on the specific type and severity of the fungal infection. Thus, consulting a healthcare professional is crucial to determine the most appropriate treatment.
- NCBI: Azole Antifungals: More Than 50 Years of Prescription
- NCBI Bookshelf: Antifungal Agents
- ScienceDirect: Antifungal therapy: past, present, and future perspectives
Nizoral Shampoo: Clinical Application and Effectiveness
Nizoral shampoo is a highly effective treatment for a variety of scalp conditions, including seborrheic dermatitis, dandruff, and fungal infections. It contains the active ingredient ketoconazole, which has antifungal properties and helps combat the underlying causes of these conditions.
Targets Underlying Fungal Infections
When applied topically to the affected area, Nizoral shampoo penetrates the scalp and targets the fungal infections that cause seborrheic dermatitis and dandruff. Ketoconazole, the key component of Nizoral shampoo, works by inhibiting the production of ergosterol, a vital component of fungal cell membranes. By disrupting the integrity and function of these cells, Nizoral effectively eliminates the infection and alleviates symptoms such as inflammation and redness.
Easy Application and Quick Results
Using Nizoral shampoo is easy and convenient. Simply apply a sufficient amount of the shampoo to wet hair, massage it into the scalp, and leave it on for a few minutes to allow the medication to take effect. Finally, rinse thoroughly to remove the shampoo.
Many users report experiencing significant improvements in symptoms after just a few uses of Nizoral shampoo, with reduced itching, flaking, and redness. It is recommended to use Nizoral shampoo regularly as directed by a healthcare professional to maintain the benefits and prevent recurrences of scalp conditions.
Safe and Well-Tolerated
Nizoral shampoo is generally well-tolerated and safe for long-term use. It is important to follow the instructions provided by your healthcare professional and the packaging to ensure optimal results and minimize any potential side effects.
However, it is always advisable to consult a healthcare professional before using any medication, including Nizoral shampoo, especially if you have any known allergies or underlying medical conditions.
Nizoral shampoo, with its active ingredient ketoconazole, is a highly effective and well-tolerated treatment for seborrheic dermatitis, dandruff, and fungal infections of the scalp. Its unique mechanism of action, targeting fungal cell membranes, sets it apart from other over-the-counter shampoos. Regular use of Nizoral shampoo can help alleviate symptoms, improve scalp health, and restore confidence in the appearance of your hair.
- Study on the effectiveness of Nizoral shampoo for seborrheic dermatitis
- Overview of antifungal medications and their mechanisms of action
Cost-effective options and availability of Nizoral
For Americans with low wages and without insurance, finding affordable medications is crucial. Fortunately, Nizoral offers a cost-effective solution for individuals seeking treatment for fungal infections.
One of the advantages of Nizoral is its availability at a more affordable price compared to brand-name antifungal medications. Generic versions of Nizoral, sourced from India, can be a viable and cost-effective alternative. It’s important to ensure the quality and safety of the medication when purchasing online, so it is recommended to purchase from reputable and regulated sources.
Nizoral does not have any black box warnings, indicating that it is considered safe for usage. This makes it a reliable option for individuals in need of inexpensive medicines.
When considering cost-effectiveness, it is essential to find reliable and credible sources of information. For more information about Nizoral and its availability, you can consult authoritative sites such as the U.S. Food and Drug Administration (FDA) website or reputable online pharmacies recognized for their commitment to quality and compliance standards.


text:
Marvel Comics decided to make a big change with Deadpool in the comics. The costumed Wade Wilson soon gets a major makeover. Large parts of the character’s past will be eradicated from his memory. This becomes a sly way to separate the new Deadpool reboot from the previously-established continuity. Fans of the bizarre anti-hero might become furious over such a decision. The invest emotionally in a popular character. When the stories they grew fond of are eliminated from continuity, anger sets in.
Fans must come to grips with a simple fact about the comic book industry: it is a business. In fact, comic book publishing has always been a business. Publishing decisions often derive from a careful look at the proverbial bottom line. Wiping away aspects of Deadpool’s continuity makes the “Merc with a Mouth” more accessible to newer readers. If new readers aren’t burdened by a convoluted history and continuity, they’ll be more likely to continue to purchase the comic.
The change comes as the current Despicable Deadpool book hits issue #300. Once this issue hits the stands, an era comes to an end. Writer Gerry Duggan leaves the title after five years. A new book gets launched with a totally new creative team at the helm. The transition to a new title with a new continuity makes perfect sense here.
Of course, all this is timed for the release of Deadpool 2. The sequel to the original hit film appears to be headed towards a big opening weekend. The humorous trailers aren’t exactly hurting the film’s box office potential. When Deadpool 2 arrives on screens, the hype will carry over to the actual comic books. Sad to say, the red-hot popularity of superhero movies never transferred over to the published books. Sales lack vigor. The release of a new movie, however, does commonly create a big spike in sales for a corresponding book. This is doubly true when the book displays “Issue #1” on the cover.
The high sales usually taper off after a few issues. Rebooting Deadpool could extend those spiked numbers.
Fans should not become too dismayed at Marvel’s decision to wipe away Deadpool’s memory. The previous continuity still exists. Deadpool just won’t remember it. In time, those memories may come flooding back. Old storylines will be integrated back into the books. For now, Marvel Comics must cater to new readers. That’s just a simple business direction that makes sense.

domain: entertainment


Mud on pavement
Reported anonymously at 20:14, Mon 16 April 2018
Sent to Stratford-on-Avon District Council and Warwickshire County Council less than a minute later
Grass verges destroyed on entrance in/out of BT sub station meaning the pavement is now thick with mud making it difficult to pass and forcing pedestrians to go onto the highway to avoid walking thru mud.
Provide an update


text:
On April 14th, after nearly 20 years, a new season of the groundbreaking series Mystery Science Theater 3000 (MST3K) will be making its debut. Fourteen new episodes are set to launch on Netflix, adding to the already existing 197 (and one feature… Continue Reading →
Good science fiction poses a compelling ethical question, against a backdrop of advanced technology, within a context relatable to an audience of the storyteller’s choosing. Passengers does all of that, but the audience may not be chosen terribly well, and… Continue Reading →
Star Trek had a big week.


text:
Cauliflower Benefits: 7 Ways This Vegetable Helps Your Health
Cauliflower has exploded in popularity recently—making its way into everything from pizza crust to hot cereal, and also replacing rice in grainless bowls, stir-fries, sushi, and more. The rise in status of this white vegetable may be a surprise to some, but it makes sense from a nutrition perspective. Here are seven reasons why you should jump on the cauliflower bandwagon.
Cauliflower is nutrient dense
One cup of raw cauliflower provides over 75% of the daily minimum target for vitamin C. In addition to supporting immunity, this nutrient is needed for DNA repair and the production of both collagen and serotonin. (The latter promotes happiness and healthy sleep.)
Cauliflower’s vitamin K (20% of the daily target per cup) is required for bone formation, and a shortfall is linked to increased fracture risk. The veggie’s choline, roughly 10% of the daily goal per cup, plays a role in sleep, memory, and learning and muscle movement. Cauliflower also provides smaller amounts of other essential nutrients, including B vitamins, phosphorus, manganese, magnesium, and potassium.
Cauliflower is anti-inflammatory
Bioactive compounds found in cauliflower are known to reduce inflammation. The veg is also rich in antioxidants, including types known to counter oxidative stress. In a nutshell, oxidative stress occurs when there is an imbalance between the production of cell-damaging free radicals and the body’s ability to counter their harmful effects, which include premature aging and disease risk.
Cauliflower fends off the nation’s top two killers
Cauliflower is a member of the cruciferous vegetable family, which also includes Brussels sprouts, kale, broccoli, cabbage, collard greens, and bok choy. As such, it helps reduce the risk of both heart disease and cancer, the two leading causes of death in the US.
Cruciferous veggies contain natural substances that protect the bends and branches of blood vessels—areas most prone to inflammation, making it a potent protector of your heart. This is likely why, among women, a higher intake of cruciferous vegetables has been associated with a lower risk of hardening of the arteries.
Natural substances in cauliflower and other cruciferous have also been shown to disable cancer-causing substances and stop cancer from growing and spreading. A review of existing research has shown an inverse relationship between the intake of cruciferous vegetables and the risks of heart disease, cancer, and death from any cause, making cauliflower a key health-protective food.
Cauliflower fights aging
Some studies show that natural substances in cauliflower, like sulforaphane, may influence genes in ways that slow the biochemical process of aging. Cauliflower compounds have also been shown to protect brain and nervous system function and slow age-related cognitive decline.
Cauliflower helps you detox
Natural compounds in cauliflower are involved in detoxification. Many health professionals dislike the word detox, because it’s often overused and over-exaggerated. But detoxification essentially means helping to deactivate potentially damaging chemicals, or shuttle them out of the body more quickly.
Cauliflower is fiber rich
The fiber in cauliflower—nearly 12 grams per medium head—supports digestive health, promotes bowel regularity, and feeds beneficial bacteria in the gut tied to anti-inflammation, immunity, and mood.
It’s important to note, however, that cauliflower is a high FODMAP food, so it may cause digestive upset for some—particularly those with irritable bowel syndrome, or IBS. FODMAP stands for fermentable oligosaccharides, disaccharides, monosaccharides, and polyols. FODMAPs are short-chain carbohydrates that are poorly absorbed from the digestive system into the bloodstream and are rapidly fermented in the gut. This combo can trigger the production of gases, which may lead to digestive bloating, pain, cramps, and flatulence. If you have a sensitive digestive system, or you’re not used to eating much fiber, it’s not unusual to experience some GI issues should you up your cauliflower intake.
Cauliflower supports healthy weight loss
Cauliflower’s fiber supports weight management by boosting fullness, delaying the return of hunger, and helping to regulate blood sugar and insulin levels. One cup raw also provides about 3.5 ounces of water, which helps promote satiety. And eating cauliflower in place of white rice can seriously displace calories and carbs, without the need to sacrifice volume.
A three-quarter cup portion of riced cauliflower contains about 25 calories and 1 gram of net carbs (3 grams total with 2 grams as fiber). The same serving of cooked white rice provides about 150 calories and 30 grams of carb.
How to enjoy cauliflower
There are seemingly endless ways to eat cauliflower. It can be whipped into smoothies, “riced” and added to oatmeal or overnight oats, and folded into or used as a replacement for white rice in just about any dish. I also adore oven-roasted cauliflower, prepared with a little avocado olive oil, and sprinkled with a combo of sea salt, turmeric, and black pepper. It’s fantastic steamed or grilled and drizzled with a bit of dairy-free pesto or seasoned tahini, or steamed and mashed, flavored with extra virgin olive oil, garlic, and fresh or dried herbs.
In addition to white, this veg naturally comes in purple, orange, and green varieties. I recommend mixing it up to expose your body to an even broader spectrum of antioxidants. And if you’re adventurous, you can incorporate cauliflower into the many dessert recipes available online, like cauliflower brownies, cake, pudding, and cheesecake. While these goodies should still be occasional treats, it’s one more way to eat less-refined carbs and up your veggie intake!
Cynthia Sass, MPH, RD, is Health‘s contributing nutrition editor, a New York Times best-selling author, and a private practice performance nutritionist who has consulted for five professional sports teams.
via Nutrition – Health.com https://ift.tt/360th4U


Accession Number : AD0646884
Title : RESEARCH DIRECTED TOWARD THE STUDY OF INFRARED TRANSMISSION THROUGH VARIOUS ATMOSPHERES.
Descriptive Note : Final rept., 19 Dec 63-31 Aug 66,
Corporate Author : NORTH CAROLINA STATE UNIV RALEIGH PHYSICAL SCIENCE RESEARCH
Personal Author(s) : Harward,Charles N. ; Manring,Edward R. ; Patty,Richard R.
Report Date : DEC 1966
Pagination or Media Count : 37
Abstract : Previously reported work is summarized (see AD-607 401 and AD-638 747), and a detailed report is given concerning further data obtained for ammonia samples at reduced temperatures are presented and used to obtain a self-broadening coefficient relative to helium. Some data in report AD-638 747 indicate a possible temperature dependence of the optical collision diameters; further data is necessary to determine the functional dependence. It appears that the dependence is T exp.-b where b is a small positive number. A prism spectrometer was used with a sampling technique involving a continuous gas flow through the absorption cell to obtain a band strength for the 667/cm band of CO2 which is in agreement with that obtained from high resolution measurements and agrees with the spectral characteristics given by Burch, Gryvnak, and Williams. (Author)
Descriptors : (*INFRARED RADIATION, WAVE PROPAGATION), (*AMMONIA, INFRARED PHENOMENA), ABSORPTION SPECTRA, INFRARED SPECTRA, HELIUM, INTERACTIONS, SPECTROMETERS, BAND SPECTRA, CARBON DIOXIDE
Subject Categories : Infrared Detection and Detectors
Atomic and Molecular Physics and Spectroscopy
Distribution Statement : APPROVED FOR PUBLIC RELEASE


text: Copaiba oil-resin is ideal for skin conditions; It helps heal wounds and helps to activate blood circulation, resulting in great help in cases of varicose veins. Copaiba oil-resin is the best ally for a healthy body, so that its application is ideal for psoriasis, herpes, dermatitis and fungi, which stands out as an exceptional natural antifungal. Apply to the affected skin with prolonged massage. The oleoresin of copaiba is composed of sesquiterpenes (caryophyllene) and diterpenes (copalic acid, kaurenoic acid), responsible for anti-inflammatory and antimicrobial activity. Copaiba oil is used as a fixative in the perfume industry and in the preparation of soaps, creams and other cosmetic products for its emollient and antibacterial properties.

domain: chemistry


text:
"Don't be Late" Baby Shower Cake
I loved making this special cake for a theme shower, really you aren't supposed to copy any Disney characters so I kinda had to change "Alice" up a little bit, but still it had a fun feel to it. I loved the colors and the detail. I made the fondant myself with a lemon essence to match the lemon and raspberry cake. I loved just the smell of it while working with it!
The woman who ordered it from me met me with tears in her eyes to tell me how much the sentiment from this special cake helped her bond with her new daughter in law. Awww, being part of people's special moments was the greatest part of my job!


text:
In the early days of the HIV epidemic, knowledge about the natural history of HIV accrued rapidly. However, the widespread use of effective antiretroviral therapy (ART) brought a shift in focus of the research community away from studies of natural history to those of treated infection. Nevertheless, recent years have seen many advances in our knowledge about natural history. For the purposes of this review, we will focus on three areas of relevance to treating clinicians: long-term nonprogression and viral control; predictors of viral load set point and disease progression; and the potential impact of ART in early HIV infection.
LONG-TERM NONPROGRESSORS AND ELITE CONTROLLERS
The natural course of untreated HIV infection varies widely. The past decade has seen considerable interest in the identification of subgroups of HIV-positive persons who exhibit distinct patterns of disease progression. It is hoped that the information obtained through the identification of such individuals might provide insight for the development of vaccines and novel treatment approaches.
Long-term nonprogressors (LTNP) are individuals who remain asymptomatic for a prolonged period of time off ART with a high CD4 cell count (see reviews by Poropatich and Sullivan and Gaardbo et al.[1,2▪]). Although it is widely reported that 1–5% of the HIV-positive population are LTNP, these estimates are complicated by the fact that there is no standardized definition of a LTNP, and thus definitions used (and the way in which they are applied, particularly in the presence of varying follow-up and irregularly measured CD4 cell counts) differ widely (Table 1) [3–5,6▪▪,7,8]. For example, Madec et al. identified asymptomatic individuals who remained off ART for more than 8 years with a CD4 cell count more than 500 cells/μl; using this definition, 9% of their clinic population were identified as LTNP. Using a similar definition but with only 7 years of follow-up, Okulicz et al. reported a prevalence of 5.02% in a military cohort. In contrast, only 0.4% of patients in the French Hospital's Database on HIV were identified as LTNP . In a UK study, Mandalia et al.[6▪▪] identified ART-naive asymptomatic individuals infected with HIV for more than 7 years. Of 312 such patients, only 50 had stable CD4 cell counts, with only 13 having CD4 cell counts consistently in the normal range. Thus, LTNP represented only 0.2% of patients attending for care, a far lower rate than that reported by Okulicz et al., presumably because of the additional requirement that individuals had stable CD4 cell counts.
LTNP status can be lost, and thus the reported prevalence of LTNP within a study will depend on the required period of follow-up. In Madec's study , LTNP status was lost after 8 years in 36 of the 60 LTNP; loss of LTNP status was generally because of declining CD4 cell counts and initiation of ART, although a small number of individuals experienced Centers for Disease Control stage B/C disease. Predictors of loss of LTNP status were a high baseline HIV DNA level and a more rapid increase in HIV DNA over the first years of follow-up, suggesting the presence of ongoing (but low-grade) viral replication. Indeed, HIV RNA levels in plasma increased by 0.04 log10 copies/ml per year over the first 8 years after diagnosis. When the required period of follow-up was increased from 7 to 10 years in a military cohort , the prevalence of LTNP status dropped from 5 to 2%. The fact that an individual's LTNP status can change has led some to suggest that rather than representing a distinct group of HIV-positive individuals, LTNP are more likely to represent individuals at one tail end of a Normal distribution [6▪▪]. As such, it is likely that virtually all HIV-positive persons will eventually experience disease progression if left untreated.
More recently, interest has shifted towards the identification of individuals who are able to suppress HIV replication to such an extent that viral load levels remain undetectable in the absence of ART . These individuals are generally referred to as elite controllers or viral controllers. In the military cohort described by Okulicz et al. elite controllers were defined as ART-naive patients infected with HIV for more than 12 months with at least three longitudinal undetectable HIV RNA determinations. Individuals were allowed to have occasional HIV RNA levels up to 1000 copies/ml as long as these episodes represented the minority of all determinations. These elite controllers were distinguished from viremic controllers in whom the majority of viral loads were in the range 1000–2000 copies/ml. In total, 0.6% of 4586 individuals were identified as elite controllers and 3.3% as viremic controllers. Virological control was established a median of 1 year after seroconversion, lasted for 846 and 1085 days in elite controllers and viremic controllers, respectively, and was associated with a reduced risk of clinical progression. Interestingly, although elite controllers experienced an initial CD4 cell count increase followed by stabilization, viremic controllers generally experienced a loss of CD4 cells. Goujard et al. confirmed that elite controllers status is established early after primary infection in the Agence Nationale de Recherche sur le Sida PRIMO cohort.
Although there is clearly overlap between the LTNP and elite controller groups, not all LTNP have a suppressed viral load, and not all elite controllers have high CD4 cell counts. Furthermore, LTNP status is not necessarily protective against clinical progression. An early study from the CASCADE group  suggested that 15 and 7% of elite controllers infected with HIV for more than 16 years had CD4 cell counts less than 350 cells/μl or AIDS, respectively. A more recent study from the group  demonstrated that the proportion of elite controllers with at least one CD4 cell count less than 500 cells/μl ranged from 45 to 53%, depending on the definition of elite controllers. Sedaghat et al. noted that CD4 slopes in elite controllers varied substantially with rates of CD4 loss of up to 53 cells/μl per year in some individuals. Using a highly sensitive viral load assay, Pereyra et al. reported that the median viral load was 2 copies/ml in 90 elite controllers. Low-level viremia was present in the majority of elite controllers; CD4 loss was more common among those with low-level viremia than in those without detectable virus. Boufassa et al. reported that clinical and immunological progression in elite controllers was restricted to those experiencing viral load ‘blips’.
More recently, Groves et al.[16▪▪] identified ART-naive patients who had maintained a viral load less than 2000 copies/ml for more than 12 months. Typical controllers had an average recent CD4 cell count more than 450 cells/μl (2.1% of population), whereas discord controllers had an average recent CD4 cell count less than 450 cells/μl (0.6%). Thus, in this study, the term discord controller was used to identify individuals who had experienced a loss of CD4 cells despite viral control. There were no significant differences in viral load or demographic factors between the two groups. Interestingly, there was a suggestion of a higher frequency of infection with subtype C virus in discord controllers (40% of patients) compared with the entire clinic population of whom 25.1% were infected with subtype C; whether this overrepresentation relates to specific features of subtype C virus itself, or whether subtype C is merely a marker of infection in certain regions of the world with specific host genetic and environmental factors is, however, unclear.
As with LTNP, several studies have attempted to identify factors associated with elite controller status. Yang et al. considered the relative and absolute numbers of naive T-cells in a cohort of elite controllers with normal or declining CD4 cell counts and in ART-treated individuals. The relative proportions of naive CD4 and CD8 T cells were reduced in elite controllers, resembling the patterns seen in individuals with untreated progressive HIV infection. The authors concluded that loss of naive CD4 T cells is a universal feature of elite controllers, despite the ability of such individuals to maintain undetectable viral loads. Chen et al. suggested, based on in-vitro experimentation, that CD4 naive lymphocytes from elite controllers were less susceptible to HIV infection than such lymphocytes from progressors or uninfected individuals. This specific feature was linked with upregulation of a cellular kinase (p21). Mahnke et al.[19▪] compared patients maintaining low levels of viremia (controllers) with those experiencing disease progression within 2 years of diagnosis (fast progressors) and with progressive disease not requiring ART (slow progressors). Although beneficial human leukocyte antigen (HLA) types (HLA-B*27, B*57, and B*58) were seen more commonly in controllers (57%) they were also expressed by 23% of slow progressors. Progressors were more likely to be coinfected with GB virus C than controllers, coinfection with which has previously been reported by some to be associated with a slower rate of disease progression in HIV infection , but the CCR5 Δ32 mutation was similarly distributed across the groups. Plasma HIV viral load did not differ between progressors, but cell-associated viral load was elevated in fast progressors and lowered in controllers. Although the frequency of CD38+CD8+ T cells was a strong predictor of disease progression in the first year after HIV infection, and was sufficient to distinguish progressors from controllers, this measurement alone could not differentiate between fast and slow progressors.
As the two groups of individuals appear to be clinically distinct, suggesting differences in the processes that lead to long-term nonprogression and elite control, several research groups have attempted to investigate whether there are any demographic or biological differences between these two patient groups . Groves et al.[16▪▪] reported a more marked depletion of the naive T-cell subset in discord controllers than in typical controllers but a trend towards increased activated effector memory CD4 cells in typical controllers. CD8 T-cell activation was increased to a similar level (compared with noncontrollers) in both controller groups. The authors concluded that despite the lower CD4 cell counts in discord controllers, their CD8 T-cell activation pattern more closely resembled that of typical controllers. As with other studies, the discord controllers had higher viral DNA loads than the typical controllers, suggesting continued viral replication in this subgroup.
Shaw et al. compared viral controllers (individuals with viral load <1000 copies/ml for >5 years) to viremic slow progressors (individuals with a viral load >10 000 copies/ml but who had maintained a CD4 cell count >500 cells/μl for >7 years) and viremic progressors (individuals infected for a similar time with viral load >10 000 copies/ml but CD4 cell count <500 cells/μl). Viremic slow progressors had higher levels of markers of mucosal immune activation and low numbers of mucosal Tregs, suggesting that factors other than immune activation account for this phenotype. Gaardbo et al. reported that LTNP had a higher frequency of activated CD4 and CD8 cells compared with viral controllers, but similar levels to progressors. Ballana et al. confirmed results from other studies  showing that a single nucleotide polymorphism 35 kb upstream of the HLA-C gene (−35C/T) is associated with LTNP status.
HIV-specific CD4 activation is a hallmark of viral control  but, as outlined above and reviewed recently  (see Fig. 1), many other host factors have been linked with this phenotype, including cellular restriction factors such as APOBEC, tetherin, and the recently identified SAMHD1 [25,26]. In addition, several viral factors may also play a role, including deletions or mutations with the viral genes  that may have an impact on the ability of the virus to replicate. Concerted ongoing research efforts will hopefully clarify whether any of these host factors are causally related to viral control or merely reflect intrinsic variations in the ability of the virus to replicate. If any host or viral factors do have an important influence on viral replication, such a discovery will open a field of possibilities aimed at enhancing or mimicking these host factors as part of a therapeutic or preventive intervention strategy.
OTHER PREDICTORS OF VIRAL LOAD SET POINT AND CD4 LOSS
The possibility that there may be a link between the viral load set point and the viral load of the infecting partner was raised by Hecht et al. who demonstrated that in 24 transmission pairs, the viral load in the donor was closely associated with the viral load at presentation in the seroconverting partner (correlation coefficient = 0.55). Using a novel phylogenetic approach to determine heritability, Alizon et al. concluded that up to half the variance in the viral load set point among individuals in the Swiss HIV Cohort Study could be heritable from their infecting partners. These observations support the notion that HIV has varying intrinsic replicative capacity and suggest that this feature is maintained after transmission.
Predictors of the viral load set point were investigated by Lingappa et al.[30▪▪] in 141 African seroconverters. In multivariable analysis, higher viral loads in the source partners were associated with higher viral load set points in the seroconverters. The proportion of variation in set point that could be attributed to the viral load of the source partner, after controlling for other factors, was 6%. Despite this low proportion, the authors concluded that the source partner viral load was the most significant predictor of the viral load set point in the seroconverter. Yue et al.[31▪▪] also noted the relatively small proportion of variance in the viral load set point that could be explained by the viral load in the source partner. In an analysis of 195 transmission pairs from Zambia, the viral load in source partners explained only around 2% of the variance in viral load set points of seroconverters. Overall, the viral load set point was a function of the source partner viral load, the sex of the seroconverter, the HLA class I alleles of the seroconverter, and the sharing of HLA-I alleles between partners in a transmission pair. Together, these factors accounted for up to 37% of variance in the viral load set point. Roberts et al. reported that the concentration of five plasma cytokines (IL-12p40, IL-12p70, IFN-γ, IL-7, and IL-15) predicted 66% of the variation in viral load set point in 40 South African women. Grinsztejn et al.[33▪] reported that women in the Prospective Evaluation of Antiretrovirals in Resource-Limited Settings (PEARLS) study had a lower mean preART viral load than men; whereas the sex difference was related to the CD4 cell count, it was independent of country and persisted in those with a CD4 cell count less than 200 cells/μl.
Other predictors of disease progression include transmission of resistant strains of HIV  and the envelope diversity of the virus in the individual after seroconversion [35▪]. In the latter study, viral diversity at 1-year postseroconversion was associated with accelerated progression to clinical AIDS or a low CD4 cell count, although not with the viral load set point itself. The authors could not determine whether viral diversity is a direct cause of immunodeficiency, or a consequence of the individual's response to infection. In a small study of 50, chronically infected, asymptomatic, ART-naive adults from the United Kingdom and China , the antiviral inhibitory capacity of CD8+ T cells was highly predictive of CD4 cell loss in early HIV infection. Audige et al. reported that fast progressors (those with a CD4 cell count <200 cells/μl within 7.5 years) had significantly lower postseroconversion CD4 cell counts than either intermediate (7.5–12 years) or slow (>12 years) progressors; fast progressors had cell-surface CD4 densities that decreased more rapidly than slow progressors.
ANTIRETROVIRAL THERAPY DURING PRIMARY HIV INFECTION
There is global consensus that there is a favourable benefit : risk ratio for initiating ART in those with HIV-related symptoms or with a CD4 cell count less than 350 cells/μl. Because of the risk of disease progression in these individuals, the benefits of ART outweigh any potential risks of adverse drug reactions. Such a favourable benefit : risk ratio has not yet been established for initiating ART earlier in the course of infection in asymptomatic individuals.
Several recent publications provide further evidence that initiation of ART during primary infection may prevent the immunological deterioration, which would otherwise be seen in untreated HIV infection. In one observational study, 64% of individuals who initiated ART during primary infection maintained a CD4 cell count more than 900 cells/μl compared with only 34% of those who deferred ART to a later time [38▪]. In the Short Pulse Anti Retroviral Therapy at HIV Seroconversion (SPARTAC) trial, 366 adults with primary infection were randomized to receive either short-term (12 weeks) or longer term (48 weeks) immediate ART, or to defer ART until the CD4 cell count dropped to less than 350 cells/μl [39▪▪]. Immediate use of ART reduced the chance of experiencing a CD4 cell count less than 350 cells/μl while the patient remained on ART, but not beyond the duration of treatment. Using data from the observational CASCADE collaboration, Zugna et al.[40▪] reported that although individuals initiating treatment within 12 months of seroconversion were more likely to interrupt therapy than those initiating treatment during chronic infection, rates of virological failure and treatment change were similar between the two groups.
Although these studies demonstrate that ART can prevent the deterioration of the immune system which would otherwise be seen without treatment, they do not address whether those initiating ART during primary infection experience any long-term clinical benefit (in terms of reduced morbidity or mortality) from this treatment, and thus whether allowing CD4 cell counts to fall to lower levels will result in any appreciable negative consequences over either the shortterm or longterm. Unfortunately, such information can only be obtained from clinical endpoint studies with the requirement for substantially larger sample sizes. The ongoing Strategic Timing of Anti-Retroviral Treatment (START) study  aims to address this question.
Although the clinical, immunological, and virological course of untreated HIV infection is variable, few persons followed for more than 8–10 years remain without any evidence of disease progression. Variation in viral characteristics, host defence responses (likely explained by variation in host genetics), and environmental factors may all contribute to the variation in the natural course of HIV infection. A better understanding of the relative influence of these factors is emerging. This line of research has the potential to identify novel targets for intervention to prevent and treat HIV-infected persons.
Conflicts of interest
JDL is a member of the Executive and Scientific Steering Committees for the INSIGHT Network which is currently conducting the START trial. CAS has provided statistical input to various study designs from the INSIGHT group. There are no relevant financial conflicts of interest.
REFERENCES AND RECOMMENDED READING
Papers of particular interest, published within the annual period of review, have been highlighted as:
- ▪ of special interest
- ▪▪ of outstanding interest
Additional references related to this topic can also be found in the Current World Literature section in this issue (pp. 353–354).
1. Poropatich K, Sullivan DJ. Human immunodeficiency virus type 1 long-term nonprogressors: the viral, genetic and immunological basis for disease nonprogression. J Gen Virol 2011; 92:247–268.
2▪. Gaardbo JC, Hartling HJ, Gerstoft J, Nielsen SD. Thirty years with HIV infection–nonprogression is still puzzling: lessons to be learned from controllers and long-term nonprogressors. AIDS Res Treatment 2012;
A very detailed review of the long-term nonprogressor and viral controller phenotypes.
3. Madec Y, Boufassa F, Avettand-Fenoel V, et al. Early control of HIV-1 infection in long-term nonprogressors followed since diagnosis in the ANRS SEROCO/HEMOCO cohort. J Aquir Imm Defic Syndr 2009; 50:19–26.
4. Okulicz JF, Marconi VC, Landrum ML, et al. Clinical outcomes of elite controllers, viremic controllers, and long-term nonprogressors in the US Department of Defense HIV Natural History Study. J Infect Dis 2009; 200:1714–1723.
5. Grabar S, Selinger-Leneman H, Abgrall S, et al. Prevalence and comparative characteristics of long-term nonprogressors and HIV controller patients in the French Hospital Database on HIV. AIDS 2009; 23:1163–1169.
6▪▪. Mandalia S, Westrop SJ, Beck EJ, et al. Are long-term nonprogressors very slow progressors? Insights from the Chelsea and Westminster HIV cohort, 1988–2010. PLoS One 2012; 7:e29844.
This study provides a very detailed description of some of the difficulties encountered when attempting to quantify the number HIV-positive individuals that meet criteria for long-term nonprogression.
7. Gaardbo J, Ronit A, Hartling H, et al.HIV-infected viremic long-term nonprogressors and controllers display different immunological mechanisms for preserved CD4+ cell counts.Abstract P166, Eleventh International Congress on Drug Therapy in HIV infection, Glasgow, 11–15 November, 2012.
8. Ballana E, Ruiz-de Andres A, Mothe B, et al. Differential prevalence of the HAL-C -35 CC genotype among viremia long term nonprogressor and elite controller HIV+ individuals. Immunobiol 2012; 217:889–894.
9. Okulicz JF, Lambotte O. Epidemiology and clinical characteristics of elite controllers. Curr Opin HIV AIDS 2011; 6:163–168.
10. Goujard C, Chaix M-L, Lambotte O, et al. Spontaneous control of viral replication during primary HIV infection
: when is ‘HIV Controller’ status established? Clin Infect Dis 2009; 49:982–986.
11. Madec Y, Boufassa F, Porter K, Meyer L. Spontaneous control of viral load and CD4 cell count progression among HIV-1 seroconverters. AIDS 2005; 19:2001–2007.
12. Olson A, Meyer L, Prins M, et al.Proportion of HIV elite controllers and loss of elite status according to two commonly used definitions. 2012. Poster 290. In: Presented at 19th Conference on Retroviruses and Opportunistic Infections; 5–8 March 2012, Seattle USA;
13. Sedaghat AR, Rastegar DA, O’Connell KA, et al. T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors. Clin Infect Dis 2009; 49:1763–1766.
14. Pereyra F, Palmer S, Miura T, et al. Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters. J Infect Dis 2009; 200:984–990.
15. Boufassa F, Saez-Cirion A, Lechenadec J, et al. CD4 dynamics over a 15 year-period among HIV controllers enrolled in the ANRS French Observatory. PLoS One 2011; 6:e18726.
16▪▪. Groves KC, Bibby DF, Clark DA, et al. Disease progression in HIV-1-infected viremic controllers. J Acquir Imm Defic Syndr 2012; 61:407–416.
An interesting study that aims to determine whether there are any characteristics that differ between viral controllers who do and do not experience CD4 cell count loss and between these controllers and those who fail to suppress viraemia.
17. Yang Y, Al-Mozaini M, Buzon MJ, et al. CD4 T-cell regeneration in HIV-1 elite controllers. AIDS 2012; 26:701–706.
18. Chen H, Li C, Huang J, et al. CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p24. J Clin Invest 2011; 121:1549–1560.
19▪. Mahnke YD, Song K, Sauer MM, et al.Early immunologic and virologic predictors of clinical HIV-1 disease progression. AIDS. (in press).
A small, but detailed study to identify whether any host factors can differentiate between viral controllers and those that exhibit disease progression.
20. Tillmann HL, Heiken H, Knapik-Botor A, et al. Infection with GB virus C and reduced mortality among HIV-infected patients. New Engl J Med 2001; 345:715–724.
21. Shaw JM, Hunt PW, Critchfield JW, et al. HIV+ viremic slow progressors maintain low regulatory T cell numbers in rectal mucosa but exhibit high T cell activation. AIDS Res Hum Retrovir 2013; 29:172–177.
22. Garcia-Merino I, de Las Cuevas N, Himenez JL, et al. The Spanish HIV BioBank: a model of cooperative HIV research. Retrovirol 2009; 6:27.
23. Hunt PW, Hatano H, Sinclair E, et al. HIV-specific CD4+ T-cells may contribute to viral persistence in HIV controllers. Clin Infect Dis 2011; 52:681–687.
24. Theze J, Chakrabarti LA, Vingert B, et al. HIV controllers: a multifactorial phenotype of spontaneous viral suppression. Clin Immunol 2011; 141:15–30.
25. Want Y, Whittall T, Rahman D, et al. The role of innate APOBEC3G and adaptive AID immune responses in HLA-HIV/SIV immunised SHIV infected macaques. PLoS One 2012; 7:e34433.
26. Ayinde D, Casartelli N, Schwartz O. Restricting HIV the SAMHD1 way: through nucleotide starvation. Nat Rev 2012; 10:675–680.
27. Cruz NVG, Amorim R, Oliveira FE, et al. Mutations in the nef
genes associated with progression to AIDS in elite controller and slow-progressor patients. J Med Virol 2013; 85:563–573.
28. Hecht FM, Hartogensis W, Bragg L, et al. HIV RNA level in early infection is predicted by viral load in the transmission source. AIDS 2010; 24:941–945.
29. Alizon S, von Wyl V, Stadler T, et al. Phylogenetic approach reveals that virus genotype largely determines HIV set-point viral load. PLoS Pathog 2010; 6:e1001123.
30▪▪. Lingappa JR, Thomas KK, Hughes JP, et al. Partner characteristics predicting HIV-1 set point in sexually acquired HIV-1 among African seroconverters. AIDS Res Hum Retrovir 2013; 29:164–171.
The study authors identify that the source partner plasma viral load level is the most significant predictor of the viral load set point in 141 African seroconverters. They also identified several other predictors of the viral load set point, including acyclovir use, bacterial vaginosis in female source partners, and circumcision in male source partners.
31▪▪. Yue L, Prentice HA, Farmer P, et al. Cumulative impact of host and viral factors on HIV-1 viral-load control during early infection. J Virol 2013; 87:708–715.
The authors demonstrate that together, the viral load in the source partner, the sex of the newly-infected partner, specific HLA class I alleles in the newly-infected partner, and sharing of HLA-I alleles between partners in a transmission pair could account for up to 37% of the variance observed in the newly-infected individual's viral load set point.
32. Roberts L, Passmore J-AS, Williamson C, et al. Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression. AIDS 2010; 24:819–831.
33▪. Grinsztejn B, Smeaton L, Barnett R, et al. Sex-associated differences in preantiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4+
T-cell count. Antivir Ther 2011; 16:1057–1062.
Interesting data to suggest that women in resource-limited settings have lower viral load set points than men.
34. Harrison L, Castro H, Cane P, et al. The effect of transmitted HIV-1 drug resistance on pretherapy viral load. AIDS 2010; 24:1917–1922.
35▪. Rachinger A, Kootstra NA, Gijsbers EF, et al. HIV-1 envelope diversity 1 year after seroconversion predicts subsequent disease progression. AIDS 2012; 26:1517–1522.
The author provides interesting data to suggest that viral diversity soon after HIV infection is associated with progression to AIDS and AIDS-related death.
36. Yang H, Wu H, Hancock G, et al. Antiviral inhibitory capacity of CD8+ T cells predicts the rate of CD4+ T-cell decline in HIV-1 infection. J Infect Dis 2012; 206:552–561.
37. Audige A, Taffe P, Rickenbach M, et al. Low postseroconversion CD4 count and rapid decrease of CD4 density identify HIV+
fast progressors. AIDS Res Hum Retrovir 2010; 26:997–1005.
38▪. Le T, Wright EJ, Smith DM, et al. Enhanced CD4+ T-cell recovery with earlier HIV-1 antiretroviral therapy. N Engl J Med 2013; 368:218–230.
An observational analysis that provides supportive data on the benefits of treatment during early HIV infection.
39▪▪. SPARTAC Trial InvestigatorsShort-course antiretroviral therapy in primary HIV infection
. N Engl J Med 2013; 368:207–217.
The first randomised controlled trial to demonstrate the value of AVT during primary HIV infection for the prevention of immunological decline.
40▪. Zugna D, Geskus RB, De Stavola B, et al. Time to virological failure, treatment change and interruption for individuals treated within 12 months of HIV seroconversion and in chronic infection. Antivir Ther 2012; 17:1039–1048.
A detailed analysis from the CASCADE Collaboration of seroconverter cohorts that suggests similar rates of virological failure in individuals initiating treatment soon after seroconversion to those initiating during chronic infection.
41. Babiker AG, Emery S, Fatkenheuer G, et al.Considerations in the rationale, design and methods of the Strategic Timing of AntiRetroviral Treatment (START) study. Clin Trials (in press).


text:
[MUD-Dev] The Best Guy on the Mud Thing
Jon A. Lambert
jlsysinc at ix.netcom.com
Wed Sep 15 21:28:34 New Zealand Standard Time 1999
>From- Dundee <SkeptAck at antisocial.com>
>Anyway, we're looking at maintaining a mud-wide ratio for each skill:
>number of times this skill is used to the number of times all skills are
>used. Then each player will also have a ratio: number of times the player
>has used this skill to the number of times he's used any skill.
>So a player that uses a skill more often than the mud-average will be
>better at it. Players that use skills less often than average would be
>worse at it. And since it's a ratio and not a skill level then it won't
>matter whether you play a lot or a little. You'll just be better at the
>skills you use more often, and worse at the ones you don't.
Some good ideas. Could there be problems with players using mule
characters to bring the average skill down? Or how about players who
log on once, create a character to check it out and don't play again?
Would there be large changes in skill just after you run utilities to
clean up dead player files? Would older players skills go up every
time there is an artificial influx of newbies, such as after an advert?
MUD-Dev maillist - MUD-Dev at kanga.nu
More information about the MUD-Dev

domain: game


Bengaluru's tax defaulters, beware! BBMP planning to use drones to survey properties
The Bruhat Bengaluru Mahanagara Palike (BBMP) is planning to install drones in order to conduct survey, 3-D map buildings and verify property owners' claims during the payment of tax.
New Delhi: The Bruhat Bengaluru Mahanagara Palike (BBMP) is planning to install drones in order to conduct survey, 3-D map buildings and verify property owners' claims during the payment of tax.
The approach has been included in Bengaluru's smart city planning report and will soon be pushed for the Centre's consent. The initiative, which includes mapping, is expected to upgrade the entire system of property tax collection.
"Three dimensional (3-D) mapping will help us form a more realistic documentation of the properties in the city. Clear images will help us check violations that property owners may resort to. We will prepare a detailed project report and call for agencies to help us in surveying the properties using drones. Drones can also get us images from congested areas which are a problem during manual or machine-supported surveys," The Times of India quoted an official as saying.
The 3-D mapping project is an add-on approach of the civic body that is likely to evolve a GIS-enabled property tax collection as well as the information system. This move was initiated after the BBMP and the Indian Space Research Organisation (ISRO) jointly discovered nearly 19 lakh properties that use spatial mapping. Following this, unique digital identification numbers will be provided to respective properties.
Distinct survey of high-end properties like malls and tech parks has been taken into consideration, according to a standing committee member on finance and taxation.
"A digital survey report of all malls, tech parks, and major industrial hubs will be prepared. This is also to trace property tax defaulters as we have found that many of them have undervalued their property tax in the self-assessment scheme," TOI quoted him as saying.


text:
Over 30 women take 1st place in the Great Lakes Women's Soccer League
U17 Boys win college showcase tournament
Kickers Bring Home Cup in 3-0 Final
Kickers College Players
Congrats to Coach Erika Kulhman and her the Over 30 women’s team who took 1st place in the Great Lakes Women Soccer League. This group of lady’s has been playing together for several years and this year had great success in there division.
The Kickers still have tickets available for the ICC Game between Chelsea and Real Madrid at the “Big House” in Ann Arbor. The tickets include a roundtrip bus ride from Carpathia Club to the game and back. Buses leave at 1:00 PM. Contact Linda McVettie : 248-854-4933
Still looking for just the club to play for ? The Kickers would like to invite you to additional tryouts M-W at the Carpathia club. Where : Carpathia Club 38000 Utica Rd. Sterling Hghts MI 48312 When : 6:00 – 8:OO pm Who: All ages U8 – U18 Especially Looking for : Girls : ’00 and ’01 […]

domain: sports


It seems we can’t find what you’re looking for. Perhaps searching can help.
HERE COMES THE RIDE
Bob and Amanda Haberberger, Union, MO
Bob: 1970 Duster Racecar
Wife, Amanda: 1969 Dart Convertible
Dad, Leroy: 1973 Duster
The best man, Clayton: 1968 Super Bee
Brother, Brian: 1972 Barracuda
It’s no surprise that when Bob and Amanda Haberberger got married in 2014, they and their wedding party drove down the aisle in vintage Mopar® cars. After all, Bob owns the same 1970 Duster his dad drove when Bob was a baby. It’s even less of a surprise that Amanda’s wedding “walk” down the aisle was also Mopar inspired – she drives a 1969 Dart.
On their one year anniversary, Bob wrote this of his bride: “Happy anniversary to the girl who loves me and respects me for who I am, the girl who isn’t afraid to pick up a tool and work, and the girl that’ll jump in the truck and drive across country with me because I see a car that’s cool … I love you beautiful!”
To the Haberberger’s, cars are also about family. In good times and in bad, “Mopar has been a huge part of my family for as long as I can remember,” says Bob. Even when his father Leroy was diagnosed with colon cancer, Mopar was part of the healing process. “My dad had a ’73 Duster — completely stripped. When dad was in the hospital my brother Brian and I asked him if we could work on the fender. We got it into the shop, called up our friends and completely restored the whole car.” When Leroy came out of the hospital and saw the car, the Haberberger boys recall his expression — it was 100% joy.
“There’s something about those Mopar cars that just keep going and going. I think the same is true for the people who connect with them, because my dad is in remission and going just as strong as that Duster.”


text:
Simmer the mushroom trimmings and a few chopped tomatoes in the vegetable stock to enhance the flavor. Slideshow: More Delicious Risotto Recipes
In a heatproof bowl, soak the dried porcini mushrooms in the boiling water until softened, about 20 minutes. Rub the mushrooms in the water to remove any grit, then lift them out of the soaking liquid and coarsely chop. Reserve the mushroom soaking liquid.
In a medium saucepan, bring the vegetable stock to a boil. Cover and keep the stock at a bare simmer over low heat. In a large saucepan or medium enameled cast-iron casserole, melt 2 tablespoons of the butter in the olive oil. Add the onion and garlic and cook over moderate heat until softened but not browned, about 4 minutes. Add the cremini mushrooms and cook, stirring, until they are softened, about 4 minutes. Add the rice to the pan and cook, stirring, until coated, about 1 minute.
Add the white wine to the rice and simmer until it has almost evaporated. Add the chopped porcini mushrooms and the reserved mushroom soaking liquid, stopping before you reach the grit at the bottom. Add enough hot stock to just cover the rice and cook, stirring constantly, until the stock has been absorbed. Add more stock. Continue cooking and stirring, adding more stock as it is absorbed, until the rice is just tender and a creamy sauce forms, about 30 minutes.
Remove the porcini risotto from the heat and stir in the remaining 2 tablespoons of butter and the grated Parmesan cheese. Season the risotto with salt and pepper and ladle it into shallow bowls. Top the risotto with Parmesan shavings and serve.
I made this recipe and it came out awesome!

domain: food


text:
First, many studies off ADHD are comprised away from predominantly (otherwise exclusively) men players, limiting all of our understanding of ADHD in females; even when efforts to investigate ADHD in women are expanding (age.grams., Biederman et al., 1999, Hinshaw ainsi que al., 2006). After that, new DSM-IV requirements getting ADHD was mainly based mainly towards the observations of men (Lahey ainsi que al., 1994), and DSM-5 job knowledge incorporated a heightened percentage of men (Clarke mais aussi al., 2013). 2nd, the majority of our information about gender outcomes when you look at the ADHD is inspired by medical products, but really referral prejudice associated with intercourse signifies that degree into the scientific trials may well not supply the full visualize out of intercourse differences in ADHD, otherwise generalise with the full ADHD people. Concurrently, some body whose ADHD is not diagnosed are missing out-of medical trials thereby conclusions might not be completely applicable so you’re able to lady if the they are with greater regularity ‘missed’. Also, early in the day meta-analyses stress that clinic-called females may possibly not be representative away from non-known lady in the sense that men are (Gaub and you will Carlson, 1997, Gershon, 2002). Third, an extra test from inside the determining intercourse variations in ADHD would be the fact at this point, nearly all studies out of inhabitants otherwise low-introduced products enjoys used father or mother or teacher rating scales. In the event the a male label of ADHD ‘s the norm, potentially only the most severe ladies or men and women whose symptoms reveal because turbulent habits could well be identified.
What is very important, particularly for systematic practice, to explore phenotypic differences in girls and boys which have ADHD (Taylor et al., 2016), and gender distinctions past that of ADHD episodes. You to definitely theory is when newest symptomatic criteria and you may attitudes out-of ADHD characterise a male stereotype, and/or if perhaps there is certainly a woman defensive impact, upcoming female tends to be less inclined to see symptomatic requirements otherwise located an ADHD diagnoses except if the attacks are created much more popular of the additional trouble, for example greater emotional difficulties or college handicap.
To handle the brand new methodological factors intricate more than, the modern data checked data from a populace-mainly based twin test, overcoming activities regarding recommendation and you will infirmary bias. Separate trait and symptomatic steps of ADHD had been readily available and this stretches strategy generally used in population-centered examples. I tested exactly what properties identify ladies fulfilling symptomatic criteria (on Parental Membership out of Youngsters Attacks [PACS]) out-of females that do maybe not despite higher ADHD symptom account with the a get-size measure of ADHD, of course an equivalent pinpointing functions work in boys. We tested center ADHD danger sign proportions, co-going on behavioral and psychological trouble, and you can disability. We plus analyzed sex-situated biases in parental attitudes out-of ADHD periods by the examining whether or not, even with their offspring meeting symptomatic requirements, mothers systematically lower than- or over-speed in line with the newest PACS, if in case that it differs to own boys and girls.
Users had been 283 college students: 153 (21% girls) which fulfilled DSM-5 search symptomatic criteria getting ADHD according to research by the Parental Membership regarding Young people Attacks (PACS) investigator-ranked adult interview (M = 9.33 age, SD = 0.77) and 130 (38% girls) whom shown a higher-level of ADHD episodes based on adult declaration using DSM-5 symptom standards however, didn’t satisfy complete diagnostic requirements (Meters = nine.52 years, SD = 0.88). I reference the fresh new communities since ‘detected ADHD’ classification in addition to ‘high-symptom’ classification. Subsequent specifics of the fresh new PACS is provided in the methods point and you may informative data on how the medical diagnosis is made is obtainable in the second issue. I laid out a higher level from ADHD symptoms since visibility of 5 or maybe more symptoms (regarding 18), predicated on significance included in previous training (Biederman ainsi que al., 1996, Faraone mais aussi al., 2009, Faraone mais aussi al., 2006, Shankman et al., 2009). Out of mention, three people have been destroyed their ADHD warning sign get according to research by the DSM-5 rating-scale (2 guys, step 1 woman) but came across PACS diagnostic standards, and you may sixteen (14 people, 2 women) met PACS symptomatic conditions but had lower than 5 symptoms present to your DSM-5 ADHD rating-scale; this type of people was basically within the diagnosed category (look for Fig. 1 getting a beat chart out-of how groups was basically derived).


Green Light for Series Development of the 918 Spyder
Posted by Arunas R on 30/07/2010 16:04
Stuttgart. In its session today, the Supervisory Board of Dr. Ing. h.c. F. Porsche AG, Stuttgart, gave the green light for series development of the Porsche 918 Spyder. Reflecting the overwhelming response from the public and customers to the Concept Study, the Supervisory Board gave Porsche’s Board of Management the mission to develop a production model based on the car already presented. This concept version of an ultra-high-performance mid-engined sports car with plug-in hybrid technology made its debut at the 2010 Geneva Motor Show and at Auto China in Bejing, hitting the headlines worldwide.
2010 Porsche 918 Spyder Concept