Shipping container homes are currently becoming a popular alternative for home owners wanting something different. They are highly affordable, easy to construct and have many eco-friendly benefits. For many excited architects and builders shipping containers are providing a new stunning form of architecture, where containers can be used as building blocks and major structural segments for houses, offices and even city structures.
Shipping container homes are built with overseas shipping containers. They are very affordable and extremely robust to become the framework for your home. Building a sea container home is pretty simple. Builder places one or more sea containers onto a standard foundation, cut doors & windows into the overseas sea container walls.
Next they insulate the modified container correctly to resist heat and cold, decorate it and hey presto! – your overseas sea containers have become your very own ultra modern home. The modular structure of shipping containers means that they can be relatively attached to one another. The very nature of this allows architectural designers to design both interesting and unique home designs.
Build Container Home
We already have successful examples of container homes. Container City in London, Canadian Ecopods, and the biggest container city Keetwonen in Amsterdam are just the few examples to mention here. It means the start of global container housing movement has already been made and we need to further develop the idea. container unit, container living.
The shipping containers are stacked, painted and customized to form the outer structure of the houses. Glass ceilings, walls and windows add light and give the structures a very bright and airy look. container unit, container living.
Furthermore, container home itself may become a symbol of personal commitment to green living. Such home will motivate its inhabitants and even neighbors to make other green choices, such as using alternative energy, recycling wastes, consuming water sparingly, etc. container unit, container living.
So far, the Nomadic Museum has hosted exhibitions in New York, Santa Monica, Venice, Tokyo, and Mexico City. There seems to be no restriction on where it might end up next, thanks to the versatility of shipping container architecture. container unit, container living.
Shipping Container Home Design
You can create a small cargo container cabin in the woods, or an extensive apartment complex in an urban setting. Containers can be used alone for a small residence, or combined in a modular fashion to create more complex, multi-story project. container unit, container living.
You would be surprised at the utilization of the shipping containers. There is even a massive 4.5 acre residential project where containers will be used to make a multi-story condo complex in Salt Lake City, Utah! Yes, the idea is more mainstream than ever before, especially given the recent global awareness of greenhouse gases and global warming; not to mention the gas prices we all suffered through. container unit, container living.
One of the ways is recycling or processing used materials into new products. For example, many books are now printed on the recycled paper, which allows saving millions of trees. Furthermore, breaking the stereotypes of traditional housing, more and more people make use of old shipping containers for building eco-friendly houses. container unit, container living.
So if you are considering a creative building project in the near future, think about how you can incorporate this special kind of eco-friendly architecture in your plan. It’s a great way to be unique, and reusing materials is great for the environment as well. container unit, container living.
Architects are also finding cargo container housing to be an excellent solution for low-income housing since the building materials are so cheap and plentiful. Low-income shipping container housing projects have already been created in London, England, Karratha, Australia, and Amsterdam, Holland. container unit, container living.
Buy Used Shipping Containers Cheap
She indicates that these houses are much less costly to build than the traditional ones, and that they are very modern looking and can be customized to the individual needs of the buyer. container unit, container living.
There are areas stormy areas where mobile homes are quite dangerous because of their weak resistance to high winds. But a container home withstands high wind pressure easily. Buildings made of shipping containers have a Lego-like, industrial feeling, which is appealing to a lot of people. There is also a possibility to hide the steel frame, so nobody can tell your home is made out of containers. container unit, container living.
An even better option is to work with a company that specializes in cargo container architecture. They will have an expert opinion on everything you will need to do, and they might even be able to sell you a container for your home and make all of the modifications you need ahead of time. By dealing with one company, you can be sure of what all of your costs will be, since you will not need to reconcile quotes from different vendors and contractors. container unit, container living.
There are few shipping container companies that specialize just in security reasons alone. In Costa Rica, there seems to be a growing trend in security for homes because of petty theft. I have been there and have seen many homes with steel or iron cages over the windows. One thing really nice about container homes is that usually the container is made of corrugated steel and are real safe. container unit, container living.
The containers can be easily recycled into new containers or other steel items, but there is an even more practical solution: they can be used to build homes. Containers are used as makeshift dwellings in many parts of the world, but only recently architects started playing with the idea of designing a comfortable home out of them. container unit, container living.
In the future, we will likely see more and more cargo container building projects as the practice gains popularity. But for now, cargo containers are still cheap and readily available. Some companies even sell kits to create your own custom container home. container unit, container living.
Sea container houses should be very secure for one big reason. In case there is a high home robbery rate in your area. Now don’t be scared, it’s when you leave the home that it gets robbed. Every Country around the world has issues and in many countries there is crime. So it’s always a good idea to build a home that will keep out any uninvited guests. container unit, container living.
In addition to this deluxe version of a prefab home Mr. Kalkin is also planning on selling a single shipping container living space called an A-Pod. This will be equivalent to a studio apartment, and will sell for under $100,000.00. container unit, container living.
You will also need to ship the container to your building site, which might be more expensive than you think. Foundation work also needs to be done, which tacks on extra cost. Before you purchase a shipping container for your new home, consult with a knowledgeable building contractor who can accurately calculate your total cost. container unit, container living.


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D & L Snacks in Rock Springs, WY 82901 Directions, Business Hours, Phone and Reviews508 Central St, Rock Springs, Wyoming 82901 (WY)       (307) 362-2843
View All Records For This Phone #
D & L Snacks in Rock Springs, Wyoming
D & L Snacks Address:508 Central St Rock Springs Wyoming 82901 WY
About D & L Snacks
D & L Snacks is primarily engaged in Local Business. D & L Snacks operates in Rock Springs. This company is involved in Local Business as well as other possible related aspects and functions of Local Business. In Wyoming D & L Snacks maintains its local business operations and may possibly complete other local business operations outside of Rock Springs Wyoming in additional operations related to Local Business.
Directions for D & L Snacks in Rock Springs, Wyoming
Get directions to D & L Snacks of Rock Springs fast an
easy with google maps and directions.
D & L Snacks of Rock Springs in your local city of Ashburn, VA.
Reviews for D & L Snacks in Rock Springs, Wyoming
Contact Number for D & L Snacks in Rock Springs, Wyoming
Phone: (307) 362-2843
City: Rock Springs
D & L Snacks Job Positions Available In Rock Springs, Wyoming
Rock Springs Employment Statistics
|Industry||# of Employers||Avg Weekly Wage|
|Leisure and hospitality||58,657||$407|
|Management of companies and enterprises||3,839||$3,297|
|Mining, quarrying, and oil and gas extraction||360||$604|
|Natural resources and mining||2,840||$371|
|Other services, except public administration||68,970||$560|
Some interesting facts about
Number of Households: 16,418
Median Income: $72,096
Size of County: 10,427 sq mi.

domain: geography


Is it with Corning Gorila Glass? cause on some resume, it comes with Corning..
Mayank Suman, 07 Sep 2013Who said SAR=1.3 Open the official support document with SAR value urself and see http://w... moreThanx I just like the phone.I'm using xperia m from last two weeks no problem,battery life was good max 3 days with stamina mode and min 2 days average use.so nice phone with beautiful futures.
shubh90, 07 Sep 2013Alright, here are some pics i took using my xperia m in very low lighting... U guys can check ... moreNice bro..seems good.pls take some more snap in outside from a long distance and upload it.
I found something interesting. On the market there are different versions of the phone Sony Xperia M C1905.
The first is the PM-0490-BV AAA
The second is the PM-490-BV AAB
In my opinion AAB version has better display(natural colors, better viewing angles)
ps. Is it possible taht AAB version is improved version of AAA?
Anish , 07 Sep 2013No, I use the headset of Xperia l and check,the issue still exist.Hmm..so its only working fyn with headsets without Mic... Rut???
Aishath , 07 Sep 2013Only thing I don't like about phone is l high in sar value 1.30 is too much high. Other things... moreWho said SAR=1.3
Open the official support document with SAR value urself and see
SAR value is 0.85
Aishath , 07 Sep 2013Only thing I don't like about phone is l high in sar value 1.30 is too much high. Other things... moresar value under 2 w/kg doesn't cause side effects.. and phones in india got sar certification before going to sale.
Only thing I don't like about phone is l high in sar value 1.30 is too much high. Other things best. It's nice mobile
I'm using xperia M c1905 from last two weeks, It dose not restart,very nice mobile.even I connect headset while music on but no restarts,, battary last almost 2 days on everage use with stamina mode battray much better.
i m using xperia m last two week.specification and feature are awesome at 12k.bt i experience a problem on it "when play video or photos then it show greenishin colour in small amount at the faces.
Alright, here are some pics i took using my xperia m in very low lighting... U guys can check these and decide about the camera for urself...:
Galaxy Core OR Xperia M Dual
Galaxy Core Adv:
1-Better Camera Quality (Even xperia M is also 5M)
2-Larger Screen 4.3
4-More Internal Memory (8 GB)
Sony Xperia M Adv:
1-Even it's 1GHZ but it's faster processor than Core 1.2 (A5 Chip)and better GPU
2-scratch resistant screen
3-USB OTG and HD Recording
4-LED Missed call Notification
So which better Core or Xperia M?


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(Lander, WY) – The Fremont County School District #1 Board of Trustees will convene on Tuesday, July 18, at 6 pm in the Central Administration Office located at 863 Sweetwater Street. The meeting is open to the public and can be watched via Zoom: Meeting ID: 840 7725 7573 and Password: h6HfBf
This meeting includes a public hearing on the proposed budget for 2023-24 for FCSD #1 and Tiger Joint Powers Board.
Immediately following the public hearing is their regular meeting, which includes the following seven action items.
- Personnel actions
- Approve CKA applicants
- Student Liaison Approval
- Adoption of the 2023-24 budget
- Approval of Deprecation Reserve Funds for Ice Removal/Cleaning Equipment
- Approval of Depreciation Reserve Funds for Fitness Equipment
- Accept monetary donation from LOR Foundation in the amount of $8,452 for BCE fourth grade dissection program.
The complete agenda can be viewed online here.

domain: news


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Tag: Happy Mondays
In today’s installment of Add Some Music To Your Day, we’re offering you some fantastic grooves to help you get over the hump of the midweek slump and give you a spring in your step as you take on the world!
Taken from the London Records release, The Early EP’s.
Taken from the Mute Records release, Good Together.
The true tale of Manchester’s legendary and notorious twenty-four hour party people.

domain: artistic


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“Burj Khalifa tower” is a skyscraper height of 828 meters in Dubai, the tallest building in the world. The shape of the building resembles a stalagmite. The opening ceremony was held on 4 January 2010 in the largest city of the United Arab Emirates — Dubai. The building is planned to open on 9 September 2009 simultaneously with the opening of Dubai metro, but the opening was postponed to January 2010 due to reduced funding by the developer. The exact height of buildings is 828 m (163 floors). “Dubai tower” was designed as a “city within a city” — with its own lawns, boulevards and parks. The total cost of construction — about $ 1.5 billion. The Burj Khalifa is a key element of the new business center in Dubai. Inside the complex there are hotels, apartments, offices and shopping malls. The building has three separate entrances: the hotel entrance, the entrance to the apartments and the entrance to the office. The Armani hotel and the offices of the company occupy floors 1 through 39 (except for the 17 and 18 floors, a technical floor).
The beginning of the heyday of the slave system in Ancient Egypt historians refer to the III Millennium B. C. the ancient Egyptian pharaohs who were enslaved in those distant times of neighboring peoples and owned hundreds of thousands of slaves, was a well-known simple cooperation of labour, the joint participation of groups of people in various related works.
New economic and technical possibilities of the ancient Egyptian state used for the construction of huge temples and pyramids. The architecture of the pyramids, which served as burial places of the pharaohs, in its development went from simple designs to more complex and perfect.
It should be borne in mind that each building is created primarily for specific practical purposes, renders its shapes and sizes different emotional impact on people. About the power of this influence was known in ancient times. Continue reading
Official name – Kingdom of Belgium (Royaume de Belgique, Koninkrijk Belgie, Kingdom of Belgium)
The Capital Of Belgium – Brussels. Here attracts tourists . the Central square in the Gothic style (XV century); the Royal Palace; the Cathedral of St. Michael (XIII-XVI centuries), famous for its stained-glass Windows; the town hall with a 90-meter watch tower; Palace of justice (XIX century); Gothic Guild houses (XVII century); the symbol of the capital – the Manneken-Pis (Manneken Pis). If you like museums, here is a basic list of Brussels museums: municipal Museum, it is situated in the building of the Royal Palace (XVI-XVIII century), the wax Museum, the Museum of classical art with a collection of Flemish painters, the Royal Museum of art and history (here you will find one of the richest collections of Egyptian antiquities, Chinese and pre-Columbian art of America), the Meunier Museum, the Museum “Mini-Europe” in this Museum there are over 100 miniature models of monuments of history and architecture of Europe in 25-fold scale. In Brussels, you can relax in the Park”hill of the arts”, or you can drive 14 km to the North of the city, here is the State Botanical garden. Continue reading

domain: design


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Why am I here? Do other women feel like this?
I am 34 years old, married to a wonderful man of 12 years. Am a true devoted Christian, love God. I have such a great desire to be a better person. I at times fall short, I feel, of my responsibilties as a woman, mother, wife, and would love to better things.
I would like to discuss how other women feel in their everyday life dealing with their responsibilities, etc. Sometimes I feel I am the only one who has certain feelings and then I feel guilty. Is anyone else like me? What are my true responsibilities? Why am I here?

domain: psychology


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Lunch is served from 11 a.m. to closing at Medley. We offer a light assortment of sandwiches, soups and salads. Our sandwiches and soups are served with your choice of Perfectly Crunchy Not Your Mother’s Slaw or Kathleen’s Red Potato Salad.
Click here to download our full menu as a pdf.
Medley is two years old on July 1st!
Medley— the perfect spot for a Mother’s Day meal out
In which our Irish heritage jazzes up our March menu
Designed by: Press75.com | Powered by: WordPress

domain: food


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more recipes like:
“ This casserole version of a French classic relies on the ease of canned soups to sauce chicken with ham and Swiss cheese.”
Everything you need to party like a leprechaun.
New for spring! Good-for-you food you’ll love to eat.
Delicious recipes, party ideas, and helpful cooking tips! Get a year of Allrecipes magazine for just $9.99!
Read our allrecipes.com blog


Oppose Attempts to Ban Salman Rushdie
The Communist Party of India (Marxist-Leninist) strongly condemns the move by the Rajastan state government with the approval of the central government to prevent the visit of Salman Rushdie to participate in the Jaipur Literary Festival, in the inaugural session of which he had attended in 2007. This is done in the name of an unlawful fatwa issued by an Islamic fundamentalist institution when the state and central governments are duty bound to protect the constitutionally guaranteed right to freedom of expression. One may not agree with what Salman Rushdie says. But even as the Supreme Court of India has underlined, the government has to protect his right to freedom of expression. It is a shame that following the Ayatollah Khomeni’s infamous fatwa of 1989 the government of India had proscribed Rushdie’s novel The Satanic Verses. Even then Salman Rushdie has been in India many times in recent years and holds a PIO (person of Indian origin) card allowing him to enter India without a visa. In spite of this, the ridiculous arguments given by the Rajasthan government now that due to law and order problems the organizers should withdraw the invitation to him is absolutely ridiculous and should be condemned by all democratic forces.
It is clear that the Congress party, so also other parties including BJP, are trying to utilize this issue for their sectarian interests of vote bank politics in the UP elections. By pampering the fundamentalist forces while one section tries to get support of the religious minorities in the elections, pointing it out the other section tries to get support of those of the majority religion.. It is because of these communal appeasement policies of the UPA government, the Hindutva Parivar and the BJP in the states where it is in power are emboldened to pursue communalization policies like the forced ‘Surya Nmaskar’ in MP schools and such other practices with immunity. In this way both majority and minority religious fundamentalists are strengthened by the communal appeasement policies of central and state governments.
Such communally motivated calls and the way the ruling class parties pander to such calls show how bigoted and religiously polarised our so-called “secular” state really is. As a result, many of the best artistic talents were driven out of India with perceived insults to different religions. Mohammed Fida Hussain died in exile due to being driven out of India by the Hindu fundamentalists and even a so-called secular state government like the one led by CPI (M) in Bengal was unable to defend the democratic rights of Tasleema Nasreen.
In such an atmosphere, where banning of books and persons, where restrictions on expression and even on thought, are becoming the order of the day, it is not difficult to see how the Government can have the guts to curb even social networks like Facebook and Google.
We call upon all genuine progressive and democratic forces to defend secular principles by firmly standing against both majority and minority fundamentalisms, and against the Indian state and the ruling class parties pampering both for their sectarian ends, and to intensify the struggle for real democracy with real freedom of expression.
K. N. Ramachandran
General Secretary, CPI(ML)
Dated 19th January, 2012.


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This question has been answered by the relevant Government Department.
Lord Mendelsohn to ask Her Majesty's Government how many formal complaints they received about Steve Lamey while he was Chief Executive of the Student Loans Company; how many of those complaints were upheld; and what investigations were carried out into Steve Lamey's performance as Chief Executive of the Student Loans Company. HL3315
Legend for business item text
† Item that is new or altered.
[I] Indicates that the member concerned has a relevant registered interest.
* Item is an oral question.
Numbers starting HL are unique identifiers for written questions, Bills or papers.
Member's Registered Interests
There are no interests to show.

domain: law


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May I Have Your Attention, Please?: The Autobiography by James Corden
My rating: 4 of 5 stars
I’ve just finished listening to this book and I loved it. Written and released in 2011, it takes you through Corden’s life up until the birth of his son.
My personal discovery of him was through Doctor Who in which he had a couple of episodes in which he was the guest. I loved his humility and charm. Later, when I saw the Wrong Mans available on Hulu I had that moment of…”Hey! It’s that guy! I liked him, what’s this one about?”. Wrong Mans is fantastic and I was hooked from there.
Corden is open and honest about his faults and issues throughout the book. He will tell a story and occasionally thank or apologize (as needed) to the people involved in the story. Part of what I loved about the book is that he made a point to attempt to make it different. Each chapter begins with suggestions to help you best enjoy the chapter:
Best Musical Accompaniment
Best Film to Watch Alongside
Best Enjoyed with (type of food)
I really enjoyed this book and if you like James Corden and his work, I think you’ll like it too. I highly recommend listening to it as an audiobook (as I do with all memoirs) because Corden is a storyteller at heart. Plus he’ll sing for you a little.
View all my reviews


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When one thinks about the First World War in Germany, the reference points are primarily the battlefields on the Western Front. Schlachtfeld Erinnerung 1914/2014 (Battlefield of Memory 1914/2014) changes the viewpoint, examining the different national historiographies in Yugoslavia, later Serbia, Bosnia and Herzegovina, as well as in Turkey, Germany and Austria. What is remembered where and how? What images of the enemy get constructed, and what figures of identification? What role did these play in the recent way in the former Yugoslavia? Director Hans-Werner Kroesinger and filmmaker Regine Dura conducted research commissioned by the Goethe Institutes in Belgrade, Istanbul and Sarajevo.
The world premiere at HAU Hebbel am Ufer compares the research materials acquired in Sarajevo, Belgrade and Istanbul with one another–historical newspaper articles, military reports, travel guides, person memories. The performers from the previous stations appear as competing traveling salespeople in matters of historical interpretation. Is the attack on the Austro-Hungarian heir apparent Franz Ferdinand viewed as a terrorist act or as a revolutionary one? And is the attacker Gavrilo Princip an extremist or a hero? What was the real purpose of the alliance between Germany and the Ottoman Empire? Based on their experiences in workshop performances, directors and performers ask other questions: How does the context alter the meaning of a document? What do the various versions of history say about the present? What is the objective behind each of the narratives?
Exhibition: “Open Spaces” by Regine Dura
open 90min before the performances
“Open Spaces” opens up to the public the research process for “Schlachtfeld Erinnerung 1914/2014” in Istanbul, Belgrade and Sarajevo, presenting it together with works by the Istanbul Workshop “Narrating War”. The exhibition is conceived as a living archive, which provides a way to examine history in the form of a workspace.
Monday 23 June the exhibition "Open Spaces" by Regine Dura will be open one last time from 3 to 6pm. The artists Regine Dura and Hans-Werner Kreosinger will be present.
360° view of the exhibition "Open Spaces"
Following the performance on June 13, Hans-Werner Kroesinger will speak about the genesis of the play with the directors of the production venues in Belgrade and Sarajevo: the theatre scholar Borka Pavićević, director of the Centre for Cultural Contamination in Belgrade, and the documentary filmmaker and director of the Sarajevo War Theatre (SARTR) Nihad Kreševljaković. The event will be moderated by the cultural scholar and publicist Boris Buden. www.goethe.de/schlachtfeld
Ein Projekt von Hans-Werner Kroesinger und Regine Dura. Koproduktion: Goethe-Institut, HAU Hebbel am Ufer, Zentrum für Kulturelle Dekontamination (Belgrad) und Kriegstheater SARTR (Sarajevo). Förderung Recherchephase aus Exzellenzmitteln des Goethe-Instituts. Gefördert aus Mitteln des Hauptstadtkulturfonds. Gastspielförderung (BITEF/ MESS) durch das Auswärtige Amt.


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Greenback Dollar (1929-1933)
Clarence "Tom" Ashley
Open iTunes to preview, buy, and download music.
Clarence Ashley became fairly well-known during the early '60s when his career was revitalized by the Folk Revival. But Ashley had an active career during the late '20s and early '30s, both as a solo performer and with a number of groups, including the Carolina Tar Heels. Now County has collected his important early work on Greenback Dollar. A spunky version of "Little Sadie" gets things started, a woeful tale of cold-blooded murder and swift justice. The steady rhythm of Ashley's banjo infuses the piece with an infectious energy. This is also true of the gambling classic "Coo Coo Bird" and the murder ballad "Naomi Wise." These pieces feature Ashley performing solo, his banjo perfectly underlining and highlighting his slightly nasal vocal. It is interesting to note that some of the lyrics of these ballads are starker than in contemporary versions. John Lewis kicks and chokes Naomi before he drowns her, and "Old John Hardy" wants to "shoot out another man's brains." There are several vivacious songs by the Blue Ridge Mountain Entertainers, including "Baby All Night Long," "Short Life of Trouble," and "Corrina Corrina." String-band lovers will appreciate these songs. The Carolina Tar Heels prove equally entertaining with "Rude and Rambling Man" and "You Are a Little Too Small," and Ashley performs several pieces with harmonica player Gwen Foster (who was also a member of the Blue Ridge Mountain Entertainers). Foster's expressive harp playing on the title cut and "Drunk Man Blues" is a real treat. Greenback Dollar is a fine collection, representative of all facets of Ashley's early career. It will be warmly welcomed by fans of old-time music. ~ Ronnie Lankford, Jr., Rovi
Great songs, bad voice
While Clarence undoubtedly represents the back woods folk singer well, his voice leaves something to be desired. It is a little too nasal ,even for folk singing, and that is saying something. The songs on this album are classic folk songs, most of which tell beautiful and heartbreaking stories, but the vocal execution mars their bittersweet beauty. Naomi Wise ,or Little Omie Wise, as it is sometimes called, is one of my favorite folk songs but I am too distracted by the nasality of Clarence's voice to listen to the words. I have to say that you should look to other artists to get your fix of folk.
If you can't take the heat.....
Beautiful songs and melodies. One hundred years of history on twenty tracks.
It don't get much better than this
This is the real deal. Rough and raw and furious clawhammer banjo.


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Wow! I can't wait to come back from war and live a happy life!
Get off my lawn!
American dream now!
My life dream is to go to college, get a good job, and live a happy life, maybe start a family if I have time!
Does this dream still the hold true?
Marty get back to the time machine!
It looks like the American Dream in the 1950s is so different!
Most men coming back from World War 2 had hopes of coming back, moving to the peaceful suburbs, and starting a beautiful family, and live the rest of their lives happily
The dream now isn't to start a family and move to the suburbs, but to go to college, get a good job FIRST then start a family
The American dream now didn't really stay true because most Americans aren't coming back from war and they can't make a big family and live in the suburbs until they first get a successful build to make a future and start a family. Maybe the Americans coming home from war now have the 1950s American dream, but the majority of Americans do not

domain: sociology


The three-door version of the Hyundai i30 has been unveiled at the Paris Motor Show.
This new three-door version becomes the third model in the new i30 line-up, joining the five-door hatch and Tourer estate which are already on sale.
As with all of Hyundai’s new models, the three-door’s styling is influenced by the firm’s dramatic ‘fluidic sculpture’ design language.
As a result, the three-door i30 gets a more steeply raked beltline than the five-door, to make the side glass look more aggressive and dynamic, plus there are longer doors to aid access to the i30’s rear seats.
The front bumper now features a black mesh insert in the grille, flanked by redesigned foglights and daytime running lights. There’s a new rear bumper, too, which has a new foglight design over the five-door i30. A set of new alloy wheel designs completes the look.
It will be offered with the same choice of four engines and five power outputs as the five-door, together with six-speed manual and automatic gearbox options. Hyundai claims that its 126bhp 1.6-litre diesel engine emits 97g/km of CO2 gives the best power-to-efficiency ratio of any engine in the segment.
Hyundai is yet to confirm prices for the three-door version, but they will be announced, along with full specs, when the car arrives in the UK later this year.


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Okay.. now that everyone has their pressies, I can show you.. 😀
This is my Nephew’s present. A Notetaker and a pencil roll. Pirates of the Carribean theme went down very well.
My husband got a mini Notetaker for his songwriting. It was a big surprise for him.
All in all, a very successful gift giving session 😀


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Member for Shellharbour Anna Watson said despite a State Government loan announced yesterday, the start of the long-awaited Fowlers Road Bridge was still at least two years away.
“I welcome the State Government’s interest-free loan for this important road project, but it still means that the Fowlers Road Bridge won’t start for at least another 2 years.
“It’s nearly a year ago now that the State Government promised to give Wollongong City Council $22.5 million from the proceeds of the Port Kembla Port sale, which is sitting in a bank account untouched.
“I think the people of Dapto and West Dapto have only one question on their minds: when will this project actually get started?”, she said.
Ms Watson said that she was concerned that it appears the cost of the Fowlers Road project was blowing out.
“The Lord Mayor’s statement that the cost of the project was now looking like costing up to $50 million is a big worry.
“We don’t even have a design of the road link yet and cost is starting to sky-rocket.
“This can only mean further delay in starting this infrastructure project”, she said.
Ms Watson said that former State Government provided Council with a $26.5 million interest free loan in 2010, which was used to complete works on Cleveland Road, including construction of a new bridge near Dapto High School.
She said that former Federal Labor Government had also provided Council with $14 million in 2013, which is being used to fund improvements along Shone Avenue, West Dapto.
Ms Watson repeated her previous public criticism that the decision by the former Wollongong Council Administrators to cancel the Fowlers Road Bridge project was one of momentous stupidity.
17 October 2014


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Head-Turning Style. This new running headband is made for runners who love form as much as they love function. A knotted design will give you style on the run, while our DriLayer fabric wicks moisture away from your skin to keep you moving comfortably. Pump up your running style headband that adds a dash of flair.
- DriLayer moisture-wicking fabric
- Knotted design adds interest
- Reflective detail
Delivery and Returns
Estimated delivery date: 1 (based on standard shipping).
We offer free shipping on orders over $99, and free returns and exchanges for up to 30 days.


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Here you will find some more individual stories about some members of "The Gang". They look for their ancestors, they stumble upon a piece of jewelry, an old photo album or an old letter, and they start from there to go back to their roots.
Iceland is still in Halldóra's blood. The customs and passions of her ancestors' country never stop to enrich her life.
Happy who, like Ulysses, made a beautiful journey, or the dreams of the lost child .
The Lewis and Clark Expedition from Aug 31, 1803, to Sept 25, 1806, has always fascinated Pierre. One lucky day a little wooden chest brought him closer to this adventure.

domain: literature


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Inside the replacement filter is high quality granulated activated carbon from coconut shell.
The Ecosoft granular activated carbon replacement filter reduces content of chlorine and chlorination by-products, concentration of heavy and non-ferrous metals, phenol, oil products and pesticides. Improves color, taste and odor of water.
The cartridge with granular activated carbon Ecosoft 4.5 "x20" increased resource for chlorine reduction - 60 000 liters.
Can replace filters of the standard size of 4.5"×20" produced by other manufacturers.
Apartment or house inhabited up to 7 people. Replacement filter is suitable for standart BB20 housing.
Tasty water thanks to 100% granular coconut shell carbon
Extended capacity of 60 000 L
Reduction of chlorine and organic matter, improvement of taste, color and odor of water
Filter housing made of pure European food grade plastic
Applicable for reverse osmosis filters produced by other manufacturers
Benefits of using the filter
In case of timely replacement of the cartridge water after using the filter will be delicious.
Replacement filter represents cylindrical housing filled with filtering material - activated coconut shell carbon.
During the filter operation water flows through the media which absorbs chlorine and chlorination by-products, reduces concentration of heavy and non-ferrous metals, phenol, oil products and pesticides. Improves color, taste and odor of the water.
The replacement filter is intended for cold borehole or tap water only.
The filter capacity depends on the quality of feed water, and might fluctuate from the values indicated above.
Do not exceed the recommended filtration rate, this can lead to deterioration of water purification quality.
Before use, plunge a new replacement filter into cold water, and keep it submerged at least during 8 hours.
After the filter replacement, discharge at least 10 liters of filtered water into the drain.
The filter is recommended to be replaced every 3 months regardless of the volume of consumed water.
Technical and operational characteristics of granular activated carbon Ecosoft 4,5"х20" replacement filter

domain: chemistry


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Davenport University student Robert Jeffrey Blank on Sunday grabbed his diploma, took a stance and then took a face plant when he tried to execute a back flip.
Don't worry! He only hurt his pride.
Gwyneth Paltrow sings on new Coldplay record
Coldplay singer Chris Martin suggested ex-wife Gwyneth Paltrow sing some lyrics she wrote for their new single “Everglow.”

domain: celebrity


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Orange drip cake with heart lollipops
There is something to celebrate on Kingsday, are you ready yet? With this Kingsday drip cake you can put something festive on the table and celebrate the king’s birthday with your beloved. Everything turns orange on King’s Day, so you definitely can’t miss this cake.
What you need to make your orange drip cake with heart lollipops:
- 330 g FunCakes Mix for Sponge Cake Deluxe
- 225 g FunCakes Mix for Enchanted Cream®
- FunCakes FunColours Gel Orange
- FunCakes Deco Melts Extreme White
- FunCakes Deco Melts Red
- FunCakes Deco Melts Blue
- FunCakes Nonpareils Red-White-Blue
- FunCakes Choco Drip Gold
- 300 ml milk
- 30 ml water
- 5 eieren (aprox. 250 g)
- FunCakes Bake Release Spray
- FunCakes decorating bags
- FunCakes Lollipop Sticks 15cm
- Wilton Lollipop Mold Mini Hearts
- Wilton Tip #1M
- Wilton Comfort Grip Spatula Straight 22,5 cm
- Wilton Cooling Grid
- 2x Wilton Decorator Preferred Deep Round Pan® Ø 15 cm
- Wilton Icing Smoother
- Wilton Cake Leveler 25 cm
Preheat the oven to 180 ° C (convection oven 160 ° C).
Prepare 330 g of FunCakes Mix for Sponge Cake as indicated on the package. Grease the baking pan with Bake Release Spray and divide the batter into two baking pans. Bake the sponge cakes t in the middle of the preheated oven for 30-35 minutes. Let them cool down on a cooling grid.
Isn’t your oven big enough to bake two sponge cakes at once? No problem, you’re perfectly fine baking one cake after the other. Just mix the batters for the two cakes separately as well. If you leave the sponge cake batter for too long before baking it, it will loose the air. And we don’t want that! For the quantities of the single cakes, check our quantity table.
Prepare 225 g of FunCakes Mix for Enchanted Cream® as indicated on the package. Take two table spoons of this and colour it orange with the FunColours Gel.
Cut both sponge cakes twice and fill the layers with jam of your choice and Enchanted Cream®. Cover the cake all around with a good layer of Enchanted Cream® and wipe here and there with the orange cream. Pull this tight using the side scraper. Let the cake cool for an hour in the refrigerator.
Heat the golden drip as indicated on the packaging and let the drip slide down the edge of the cake.
Place tip # 1M in a decorating bag. With a brush in the seam of the piping bag, draw a line with the orange FunColours Gel up into the decorating tip. Carefully fill the bag with the remaining Enchanted Cream® and pipe small tufts along the entire top edge of the cake. Return to refrigeration.
Melt the 4 colours of FunCakes Deco Melts in the microwave as indicated on the package and place in a decorating bag. Place the lollipops in the mould and fill them with the melted Deco Melts. Let this set in the refrigerator for about 15 minutes. Now easily take the lollipops out of the mould. Place the lollipops into the cake and sprinkle some nonpareils on top.


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Durham is a relatively large city located in the state of North Carolina. With a population of 278,993 people and 59 constituent neighborhoods, Durham is the fifth largest community in North Carolina.
Durham real estate is some of the most expensive in North Carolina, although Durham house values don't compare to the most expensive real estate in the U.S.
Durham is neither predominantly blue-collar nor white-collar, instead having a mixed workforce of both blue-collar and white-collar jobs. Overall, Durham is a city of professionals, sales and office workers, and managers. There are especially a lot of people living in Durham who work in management occupations (10.81%), office and administrative support (9.40%), and healthcare (8.86%).
Also of interest is that Durham has more people living here who work in computers and math than 95% of the places in the US.
Durham is a popular destination for single career-starters. One thing that you will notice when you are out and about town is that there is a large population of people who are young, single, educated, and upwardly-mobile career starters out at restaurants, listening to live music, and enjoying other activities. They are a real visible part of the culture of Durham. This makes Durham a good place to live for young professionals. With so many people in this demographic, Durham presents many opportunities for single professionals to enjoy themselves, socialize, and to create lasting relationships.
Durham is one of the most well-educated cities in the nation. 49.57% of adults in Durham have at least a bachelor's degree. Compare that to the average community in America, which has just 21.84% with a bachelor's degree or higher.
The per capita income in Durham in 2018 was $34,329, which is wealthy relative to North Carolina, and upper middle income relative to the rest of the US. This equates to an annual income of $137,316 for a family of four. However, Durham contains both very wealthy and poor people as well.
Durham is an extremely ethnically-diverse city. The people who call Durham home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Durham residents report their race to be White, followed by Black or African-American. Durham also has a sizeable Hispanic population (people of Hispanic origin can be of any race). People of Hispanic or Latino origin account for 13.83% of the city’s residents. Important ancestries of people in Durham include German, English, Irish, Italian, and European.
The most common language spoken in Durham is English. Other important languages spoken here include Spanish and Langs. of India.


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Festival Flamenco Internacional: Compañía Marco Flores, Entrar al Juego
June 10, 2017
Festival Flamenco Internacional de Alburquerque presents Compañía Marco Flores in Entrar al Juego. In this contemporary and very theatrical production, Flores manipulates space and experiments with time—slowing it down, speeding it up, and changing its direction to open up a temporary timeline from another world and trap people and objects in an alternative dimension.
Flores’ first large-scale choreographic work, DeFlamencas, explored the female universe; his second creation, Tránsito, reflected his interest in looking within. Subsequently, he examined men’s actions and relationships in Laberíntica. With this new work, he expands his artistic focus and direction as well as the dynamics of his choreography. The creative process in Entrar al Juego, activated by intergenerational concerns, begins by bringing together artists of various ages and origins, with differing techniques and experiences. Breaking with traditional conceptions of hierarchy and methodology, Flores involves the artists in a collective composition, where the actions of each are essential to the development of the others, as all discover their own strategies to move, to be still, and to continue with the work, both individually and as a group. Along with stage director and choreographer Juan Carlos Lérida, he proposes to the participants in Entrar al Juego that they dance in a timeless place, and the audience witnesses how people transform when confronted with the need to continue, to resolve the unknown nature of that place.
$40, $50, $70, $85


Surprise! Penn Badgley is a married man. The Gossip Girl alum, 30, quietly tied the knot with his girlfriend, Domino Kirke, at a Brooklyn courthouse on Monday, February 27.
According to posts on social media, Badgley (a.k.a. Lonely Boy from the hit CW series) made it official with Kirke (who happens to be Girls star Jemima Kirke’s sister) in front of family members and friends. In sweet photos shared to Instagram by their friends and Kirke’s other sister, Lola, the bride can be seen wearing a white lace dress while Badgley rocks a sleek navy suit.
“When someone gets married in a courthouse, it’s really an open invitation to everyone but the beautiful bride to explore all that fashion has to offer,” Lola Kirke added alongside an Instagram photo with Domino and Jemima, who was dressed casually in wide-leg jeans and a T-shirt. “Here, I try a look simply called ‘Pants,’ as Cassius goes for ‘That Dude from #incubus’ and Jemima experiments with ‘Off to Therapy!’ Congratulations @dominokirke. We love you.”
Badgley has been dating Domino, who has a child from a previous relationship, since 2014. He was previously involved with his GG costar Blake Lively and actress Zoe Kravitz.
E! News was first to break the news.
For access to all our exclusive celebrity videos and interviews – Subscribe on YouTube!


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Swazi King Pays Fine For Violating Sex Ban
Swaziland's King Mswati III yesterday paid a fine for violating chastity rules that he established to combat the spread of HIV, USA Today reports (Nordwall, USA Today, 11/12). In September, the king ordered all young women in Swaziland to abstain from sex for the next five years in order to reduce the spread of HIV (Kaiser Daily HIV/AIDS Report, 10/1). The rule bans girls under the age of 18 from having sex, and Swazi custom states that a man must pay a cow as a fine if he marries an underage girl after the rule is declared. A group of 300 young Swazi women protested outside the capital after Mswati announced he would marry a 17-year-old girl. Mswati paid the group of young women the fine of one cow (AP/Las Vegas Sun, 11/11).This is part of the Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription.


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Brandy's Teenage Daughter Sy'Rai Flaunts Her Natural Beauty in a Makeup-Free Selfie – See It Here
Brandy's daughter, Sy'Rai, took to her Instagram Story to show off her natural beauty with a stunning makeup-free selfie. The 18-year-old is the spitting image of her mother and she is also a talented singer.
Brandy Norwood is known as a phenomenal vocalist, performer, and actress, but her most important job is being a mom to her only daughter, Sy'Rai Smith, who she welcomed in 2002.
Now 18 years old, Sy'Rai is the spitting image of the "Have You Ever" hitmaker and the proof is in videos and photos shared by both mother and daughter. In a recent Instagram Story post, Sy'Rai flaunted her gorgeous features in a makeup-free selfie.
In the close-up snap, Sy'Rai posed with her face slightly turned away while keeping her gaze at the camera with her mesmerizing almond eyes. She
"love a day without makeup."
Rightly so, Sy'Rai's flawless face was glowing in its natural state with only a little lip gloss to enhance her plump lips. The teen looked stylish in a printed T-shirt and a yellow bandana covering all her hair except two long braids on either side of her face.
Sy'Rai also threw on a few accessories to complete her casual-chic look including gold hoop earrings, several studs on her ear, and a necklace that was tucked into her T-shirt.
Sy'Rai's selfie showed how much she looks like her mother, but beauty is not the only thing that she inherited from her super talented, super famous mom. The teen is also gifted with an incredible voice and she is passionate about music.
Brandy, who began her career at 15 years, knows all about the ups and downs of a Hollywood career.
Last year, Sy'Rai released a new single titled "At Your Best" which sampled another music icon, Aaliyah's 1994 single of the same name. Even Brandy, who once served as a judge on "America's Got Talent," agreed that her daughter's voice was angelic.
Not only is Sy'Rai a talented singer, but she is also an influencer, a designer, and a go-getter. This combination of attributes led her to start her own clothing label, Privileged Apparel LA, in 2019.
With her artistry and ambition, Sy'Rai stands to have a successful career in fashion and entertainment, especially with the guidance of her mother, a Grammy Award-winning singer and an established actress.
Brandy, who began her career at 15 years, knows all about the ups and downs of a Hollywood career. She told People that as she navigated through child stardom to womanhood in the public eye, it's her family who helped her stay grounded.


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Currently unavailable for purchase
Original WatercolorArches 140lb CP watercolor paper11" X14"
A stylized waterlily reminiscent of stained glass. I had a lot of fun painting the water.
110 views as of 5 Jan 2011
A very serene work of art.Visit my blog
art for sale, christiane kingsley, flower, original art, pink, watercolor, waterlily
Thank you very much, Rajeev. I really appreciate your nice comment.
Beautiful watercolour, Christine. I love the way you have handled the reflection.
so beautiful..so well done!
Bev, thank you so much.
Catherine, I truly appreciate you kind comment.
This is beautiful Christiane.
Cal, thank you to a fellow Canadian!
Excellent technique, great color harmony. Can’t wait to see landscapes.
Thank you, Harry. Landscapes? Hum…one of these days, I will have to give them a try.
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Wireless Gaming Headset Case Study
A wireless gaming headset with low-latency, uncompressed, 24-bit audio and 100 meter range that also works for video conferencing.
Gaming headsets give gamers a convenient, portable way to listen and communicate while playing, without the need to set up separate headphones and microphone. Most gaming headsets are wired either to analog audio using a 3.5mm jack, or to a USB port on the gaming console. Wired headsets limit the convenience by tethering gamers to the console, thereby preventing them from getting up to grab a snack or, well, for other things.
Wireless gaming headsets using Bluetooth audio exist, but they have notoriously poor sound quality, limited range, and noticeably high latency.
Audality WiC wireless audio technology offers the best of all worlds - letting gamers get up and move around while listening and communicating with high quality sound, low latency, and incredible range.
The cables of wired gaming headsets, in particular, are liable to tangles, as well as wear and tear over time. This makes them more prone to damage and breakage compared to wireless gaming headsets.
Because these headsets have cables or wires, they can prove to be quite the inconvenience when you want to play games on your TV and sit down on your couch, or want to walk to the kitchen in between games without having to put the headset down.
- HeadPhonesty.com (March 31, 2020)
Architecting the solution
We embedded the WiC™ wireless receiver and battery within the headset, inside the headband. The antenna, the wiring connections to the earpieces, and the microphone wiring are hidden inside the headset where they are safe from any chance of damage.
The set includes the Audality USB transmitter/receiver, which plugs into the gaming console.
Integrating the package
The mechanical design is very simple because all of the components are small and lightweight. Audality has also completed all of the necessary certifications for safety, including SAR safety for proximity to the body, FCC, and CE certification.
Operating the headset
The gaming headset is turned on with the power button located on the microphone arm. The headset is paired to the USB transmitter/receiver using a simple, one-touch pairing process. The USB transmitter/receiver and headset “remember” each other, so they do not have to be paired again. The pairing button has multiple functions of turning the headset on and off, pairing, and muting the microphone.
Entering full production
Audality provided engineering and documentation support to prepare user guides and technical support materials. Audality provided guidance on manufacturing and assembly to automate the assembly and testing.
24-bit uncompressed audio
Battery life from full charge
Range in typical operating environment
Gamers have been forced to suffer with compromises – wires that confine them to within feet of the gaming computer or low-quality, wireless sound with limited range. Audality WiC wireless audio technology gives them the convenience of wireless headsets with full, uncompressed high-fidelity audio and great range.
Audality has invented the wireless audio technology that can deliver the gold standard of audio quality to headphones, microphones and speakers with incredible range and portability – WiC is the “last mile” of wireless audio.


2013 defensive back Darius Allensworth is still committed to the Arizona Wildcats, but that hasn't stopped him from taking visits to other interested schools from around the country. The 5-foot-11 ...
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A vibration study to protect the performance of sensitive laboratory equipment
The Louis A. Simpson and Kimberly K. Querrey Biomedical Research Center is a 600,000-square foot facility located in Northwestern University’s academic medical district. Designed to act as a central hub for the university’s medical research activities, upon completion the facility will feature nine laboratory floors of 40,000 square feet each, with more lab capacity being added over time. Among other functions, the Perkins + Will-designed Simpson Querrey Center will provide facilities for pediatric medical researchers studying childhood conditions that carry into adulthood, including sickle cell anemia, early metabolism of obesity, asthma, cystic fibrosis, and cardiovascular disease.
The footfalls of building occupants are often the most significant source of floor vibration on the upper floors of research and healthcare facilities. Movement in the floors of such facilities can cause discomfort to occupants and interfere with the performance of vibration-sensitive equipment. In order to ensure that their laboratories support effective clinical work and research, advanced facilities must make precise design adjustments to create low-vibration environments.
Our team was engaged to conduct a study that would quantify the vibration performance of a sensitive area of the Simpson Querrey Biomedical Research Center, to ensure that its floor structure would be sufficiently stiff and massive to resist the forces exerted by occupant traffic. The ultimate goal of this work was to provide optimal conditions for both people and advanced equipment.
Our process began with an activity we would sustain throughout the project: working closely with the structural engineers to understand the research functions and design imperatives of the spaces we were studying. After ensuring that we had the right contextual information to ground our technical analysis, we proceeded in two phases:
Setting vibration criteria.
To develop recommendations for vibration mitigation, we first needed to establish the levels of vibration that would be acceptable at various locations on the floor under study. The limits would vary from place to place according to intended usage and the sensitivity of the equipment at work there. For instance, the laboratory areas of the building were required to achieve a more stringent criterion that ensures the performance of microscopes to 100 X magnifications. Once we had a detailed map of the acceptable vibration criteria at each location, we could then proceed with our footfall analysis, determining whether anticipated vibrations fell within or outside of acceptable ranges.
Analyzing footfall effects.
As a person walks along a floor, the forces their footfalls exert depend primarily on the person’s weight and walking speed. To computationally predict footfall vibration effects, we used analytical methodologies grounded in published design parameters. We used nonlinear analysis software to develop a finite element model that represented the portion of the building under study, and then used that model to represent the dynamic behavior of the floor--to show how the floor would vibrate. The next step was to feed the output of the finite element model into our proprietary floor analysis software, FASTmapTM, which produced estimates of vibration responses at all locations across the area of the floor.
Once we had completed the full analysis, we illustrated the results using contour plots showing the vibration effects that would result from someone walking at each of the speeds we considered. These plots let us illustrate for the designers where the existing design might fail to achieve the required level of performance given the sensitivity of nearby equipment; these simple visualizations captured detailed and complex information.
Once we had identified specific sites of concern, we were able to propose specific changes to the floor framing--either the addition of structural members or increases in members’ stiffness. As we worked closely with the structural engineers to iteratively incorporate these adaptations into the design and verify their performance, the floor’s structural system evolved to achieve the appropriate vibration levels at all relevant walking speeds.
Our analysis helped the designers refine and move forward with their design, confident that it was capable of controlling the effects of footfalls at a range of speeds. This collaborative work ensured both the efficiency of the design, and its ability to perform at the level necessary for the Louis A. Simpson and Kimberly K. Querrey Biomedical Research Center to function as a top research facility. We were proud to contribute to this project, which had kept the research center’s important scientific function at the heart of its design considerations from the beginning. As Ralph Johnson, design director at Perkins+Will put it, the design was never a matter of “creating a sculpture and fitting in the [lab] plan. It’s all about the research and the labs, and that’s the generator of the idea. When you do that, the shape of the building starts to happen.”


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WALLASEY MP Angela Eagle was today dragged into the row over ministers recouping the costs of accountancy bills.
The treasury minister was named as one of 42 to have made such claims.
West Lancashire MP Rosie Cooper came under fire for claiming £915 solicitors’ fees and survey costs on a home she did not buy.
She then claimed £11,324 in stamp duty and legal fees for a London property before spending £16,000 on renovation.
She said any profit when the property is sold will be paid to the taxpayer.
Bootle MP Joe Benton claimed £400 a month in 2005 for food.


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Welcome to the Team Page of Snow College's Institute of Religion!
As part of the Million Meals in March food and fund drive, Snow College and other institutes around the state are hosting Virtual Food Drives to benefit Utah Food Bank's mission of Fighting Hunger Statewide.
374,000 Utahns, which equates to 1 in 8 Utahns, are at risk of missing a meal today. Even more alarming is that 1 in 7 Utah kids are unsure where their next meal is coming from. No child should have to go to bed hungry in Utah.
With your support, and Utah Food Bank’s purchasing power, we can truly make a difference in the lives of Utahns facing hunger!
Donating to the Virtual Food Drive is easy!
Just select the items you would like Utah Food Bank to purchase on your behalf OR select the cash item to allow Utah Food Bank to utilize your donation where it’s most needed.


Today’s young Cajun and zydeco musicians face a choice: adhere strictly to the traditions and represent the cultures, or expand upon Acadiana music and hope listeners embrace it instead of being offended.
The website of the otherwise provincial Cajun band Teechaoui Social Club promises “No New Orleans” in their sound. When asked to clarify, Teechaoui bassist Alan LaFleur responds simply, “Bourbon Street,” before clarifying his desire to make sure future generations hear authentic Cajun music music: “In New Orleans, John Fishburn plays a good version of Cajun music, but everyone else is stuck on Bourbon Street – which isn’t bad but it’s a long ways removed from Cajun culture.”
Teechaoui (a word meaning ‘little raccoon’), on the other hand, plays, “Just what you’d hear at my grandpa’s house,” LaFleur promises.
After a lifetime playing rock ‘n’ roll, rockabilly and surf (he’s led the band the Gin-n-Tonics since 1996), LaFleur moved home to Lafayette after 9/11 and finally started playing Cajun music. He spent eight years in the Lost Bayou Ramblers, infusing Cajun music with a modern sound.
His Teechaoui Social Club started fairly recently on a porch during a community boucherie. “I live in this house from the 1820s,” explains LaFleur. “And we have a boucherie there. At a boucherie you can’t come and watch; you come and learn how to do something. You make boudin; you learn by doing, not by watching.
We get about 80 people every time with 20 people playing music for about 18 hours of that day. That’s where I met my band. None of these guys are professionals except for me.”
LaFleur describes the Social Club as “a mix of people from all around Lafayette, all mixed into one music. It’s a more high-energy dancehall based style.
It’s Lafayette music.” Rather than let New Orleans influence his music, he aims to influence New Orleans, mostly with a monthly Cajun and zydeco night at hard rock club, Siberia. There, each month’s show will feature LaFleur’s band, plus another rural band of his choosing. “There are hundreds of these bands out there, each with a very different feel and viability, a different way their area spoke French and played music,” explains LaFleur. “This band’s story, and the band 10 miles down the street, are very different, so they sound different.”
I first caught LaFleur playing bass at Siberia back in April, with both Teechaoui Social Club and opening act, La Bande de Plaquemines Brulee, from Churchpoint.
Like many new Cajun and zydeco bands, the members of La Bande de Plaquemines Brulee are all in their 20s, but have been playing since they were kids.
“Churchpoint bands have the sound of Churchpoint,” says LaFleur. “They don’t like the faster dancehall. Churchpoint guys play even slower than in Eunice.
The music’s not as flashy. You won’t see my band shed a tear in the middle of the song, but with those gentleman, you’ll see that.”
The members of Feufollet from around St. Landry Parish also first took the stage as kids and by now cannot be considered a “new” band – except in their hybridized Cajun sound. The groundbreaking band, led by multi-instrumentalist (but mostly fiddle player and accordionist) Chris Stafford highlights its Cajun roots with rockabilly, classic country and new-school indie rock. In 2010, Feufollet’s self-released album En Couleurs was Grammy-nominated in the Best Cajun or zydeco category alongside legends Chubby Carrier, the Pine Leaf Boys, Cedric Watson and D.L. Menard.
The band recently raised over $30,000 to release their sixth album, which promises to feature some poppier tunes sung in English. This past Jazz Fest nola.com gave Feufollet’s new singer Kelli Jones-Savoy the thumbs up, writing that, “she moves from a piercing near-howl in Cajun French to a softer, folksier sound to husky and haunting to a slow, sultry burn.”
After a 20-year career, accordion player and multi-instrumentalist Corey Ledet is not afraid to try new things, as evidenced by the zydeco-and-brass band mash-up of Stevie Wonder’s “Higher Ground” on which Ledet plays accordion. Thirty-two-year-old Ledet traveled from his home in Houston each summer as a child to Parks, where he immersed himself in Cajun culture, especially the music. At 10 years old he began drumming for Houston-based band Wilbert Thibodeaux and the Zydeco Rascals before finally moving full time to Parks. In 2003 he formed his own zydeco band, which made Ledet famous for adhering to the sound of zydeco founding father Clifton Chenier. On his 2004 debut solo CD 3 Years 2 Late Ledet mixed first-generation zydeco, Creole, nouveau R&B and swing-out and was leaning toward accordion-based blues on 2012’s Nothin But the Best.
Ledet recently entered into a new project, Soul Creole, featuring Louis Michot of the Lost Bayou Ramblers and his wife, Ashley. “Fiddle and the triangle, I don’t normally have that in my Zydeco band,” says Ledet regarding the differences in his various bands. “This might sound strange, but we all also like ‘80s music too, so we’ll slip in a little of that. But otherwise the new band is more Creole.”
As for Ledet’s zydeco ambitions: “I am planning on doing the same as Feufollet, branching out, writing my own tunes, maybe some more mainstream stuff. We used to stick to the standards, but I might write like a country song with accordion, or a pop song on accordion.”
After more than 20 years fronting the Blue Runners, frontman, guitarist and vocalist Mark Meaux has started a fresh band, the Zordico Stompers. With a whole new repertoire and new possibilities, Meaux’s new style is still in the air. Though the Stompers feature some of his old Blue Runner bandmates, Meaux says, “I am still figuring out what this new band can do!” While he claims the new band is “more traditional” than his former, Meaux definitely aims to blend genres. “We started in the Blue Runners playing started off doing punk rock, and then zydeco, and R&B – which sounds ridiculous, but it’s a roots thing. We liked music that was stripped down, not that complicated. The biggest influence for us besides Clifton Chenier was the Carrier Brothers. In the new band we’ve incorporated Cajun music and more Creole music. That’s the fun: It’s all moving parts, and you fit the right instrument with the right tune.”


RESH Global LLC (RESH)We help you Operationalize Your Vision and Execute Your Strategy improving organizational performance.
Operating in diverse cultures across the globe with IT in designing, building and supporting systems for a few years RESH has developed a globalized understanding of organizations and the key enablers for business growth. After working , we realized the issue was not the systems but the use and application of technology. This has led to an increased focus on how systems can be used to really empower organizations.
Working with people to provide optimal use strategies for technology became a way of life. The people, direction and processes of an organization are as important as the systems that are being utilized.
It is from this concept that we engage to empower organizations helping them operationalize their vision:
Purpose - Vision and Mission
Autonomy - How do we do what we do
Mastery - How we master that which we need to do
This is the structure of our engagements to operationalize the vision for your company helping you execute your strategy.
Come Journey with us to improve Click here
The Prime Directive forms the basis of all engagements of members of the RESH Global team. This is captured in the simple view that all organizations consist of people, who exercise control and direction through processes that use technology. The appreciation of this fundamental principle creates understanding that the value created by the organization for its clients is through its people.
Prime Directive: “maximize value creation, through people, using dynamic, sustainable systems, processes and technology aligned with purpose”.


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The candidate coronavirus vaccine AZD1222, being developed by University of Oxford and AstraZeneca, generated an immune response in a study of roughly 1,000 patients, according to interim results published Monday. The results show a relatively safe vaccine – though side effects were greater than for a meningitis vaccine – and future studies will likely test giving patients two doses.
Medical Xpress reports that the early stage trial finds that the vaccine is safe, causes few side effects, and induces strong immune responses in both parts of the immune system – provoking a T cell response within 14 days of vaccination (a cellular immune response, it could find and attack cells infected with the virus), and an antibody response with 28 days (humoral immune response, it could find and attack the virus when it was circulating in the blood or lymphatic system).
An ideal vaccine against SARS-CoV-2 should be effective after one or two vaccinations, work in target populations including older adults and those with other health conditions, confer protection for a minimum of six months, and reduce onward transmission of the virus to contacts. The current trial is too preliminary to confirm whether the new vaccine meets these requirements, but phase 2 (in the UK only) and phase 3 trials to confirm whether it effectively protects against SARS-CoV-2 infection are happening in the UK, Brazil and South Africa.
Explaining how the vaccine works, study lead author Professor Andrew Pollard, University of Oxford, UK, says: "The new vaccine is a chimpanzee adenovirus viral vector (ChAdOx1) vaccine that expresses the SARS-CoV-2 spike protein. It uses a common cold virus (adenovirus) that infects chimpanzees, which has been weakened so that it can't cause any disease in humans, and is genetically modified to code for the spike protein of the human SARS-CoV-2 virus. This means that when the adenovirus enters vaccinated people's cells it also delivers the spike protein genetic code. This causes these people's cells to produce the spike protein, and helps teach the immune system to recognise the SARS-CoV-2 virus."
He continues: "The immune system has two ways of finding and attacking pathogens—antibody and T cell responses. This vaccine is intended to induce both, so it can attack the virus when it's circulating in the body, as well as attacking infected cells. We hope this means the immune system will remember the virus, so that our vaccine will protect people for an extended period. However, we need more research before we can confirm the vaccine effectively protects against SARS-CoV-2 infection, and for how long any protection lasts."
The new trial included 1,077 healthy adults aged 18-55 years with no history of COVID-19, and took place in five UK hospitals between 23 April and 21 May 2020. The data included in the paper covered the first 56 days of the trial and is ongoing. The participants either received the new COVID-19 vaccine (543 people) or the meningococcal conjugate vaccine (534 people). 113 participants (56 given the COVID vaccine, and 57 in the control group) were also asked to take paracetamol before and for 24 hours after their vaccination to help reduce vaccine-associated reactions (as the COVID-19 vaccine was given in a high dose to help induce a strong immune response).
All participants gave additional blood samples and underwent clinical assessments to determine if the vaccine was safe and whether it provoked an immune response. Participants were also asked to record any adverse events throughout the trial.
The participants were split into four groups. Group 1 (88 people) had additional safety monitoring to form the phase 1 part of the trial, and had antibody and T cell responses assessed. Group 2 (412 people) had extra blood taken to assess for antibody and T cell responses, and group 4 (567 people) had serum taken to assess for antibody response only. In groups 1, 2 and 4 half the participants received the COVID-19 vaccine and half received the control vaccine. Group 3 (10 people) received only the COVID-19 vaccine, and were given an extra dose of vaccine 28 days after the first dose to determine safety and whether this boosted antibody and T cell responses.
The vaccine was found to have an acceptable safety profile and there were no serious adverse events. Fatigue and headache were the most commonly reported reactions (around 70% [340/487] of all participants given the COVID-19 vaccine only reported fatigue, and 68% [331/487] reported headache, compared with around 48% [227/477] and 41% [195/477], respectively, of participants in the control group without paracetamol). Other common side effects included pain at the injection site, muscle ache, malaise, chills, feeling feverish, and high temperature.
Participants taking paracetamol around their vaccination had reduced pain, chills, feeling feverish, muscle ache, headache, and malaise in the two days following vaccination. In addition, in the 10 people who received the extra dose of the COVID-19 vaccine, side effects were less common after the second dose.
The authors found that there were strong antibody and T cell responses from the vaccine. T cell responses targeting the SARS-CoV-2 spike protein were markedly increased (in the 43 participants studied), peaking 14 days after vaccination (median 856 spot-forming cells per million peripheral blood mononuclear cells), with this level declining slightly by day 56 of the trial (to median 424 spot-forming cells per million peripheral blood mononuclear cells) . The T cell response did not increase with a second dose of the vaccine, which is consistent with other vaccines of this kind.
Antibody responses peaked by day 28 (median 157 ELISA units—studied in 127 participants) and remained high until the measurement at day 56 in the trial (median 119 ELISA units—studied in 43 participants) for those given a single vaccine. This response was boosted by a second dose (median 639 ELISA units at day 56 in these 10 participants).
28 days after vaccination, neutralising antibody responses against SARS-CoV-2 were detected in 32 of 35 participants (91%) (when measured in MNA80 neutralisation assay), and in 35 of 35 participants (100% – when measured in PRNT50 neutralisation assay) who received a single dose of the COVID-19 vaccine. These responses were present in all participants who had a booster dose of the vaccine (nine of nine participants in MNA80 assay at day 42, and ten of ten in Marburg VN assay on day 56).
The authors found that taking paracetamol did not affect immunogenicity of the COVID-19 vaccine.
Co-author, Professor Sarah Gilbert, University of Oxford, UK, says: "There is still much work to be done before we can confirm if our vaccine will help manage the COVID-19 pandemic, but these early results hold promise. As well as continuing to test our vaccine in phase 3 trials, we need to learn more about the virus – for example, we still do not know how strong an immune response we need to provoke to effectively protect against SARS-CoV-2 infection. If our vaccine is effective, it is a promising option as these types of vaccine can be manufactured at large scale. A successful vaccine against SARS-CoV-2 could be used to prevent infection, disease and death in the whole population, with high risk populations such as hospital workers and older adults prioritised to receive vaccination."
The authors note some limitations, including that more research is needed to confirm their findings in different groups of people – including older age groups, those with other health conditions, and in ethnically and geographically diverse populations. The authors note that these groups are being recruited in their ongoing phase 2 and 3 trials of the vaccine in the UK, Brazil and South Africa. In the current trial, 91% (979/1,077) of participants were white and the average age of participants was 35 years.
They also note that a small number of participants had detectable neutralising antibodies and T cell responses against SARS-CoV-2 spike protein before vaccination, likely to be due to past asymptomatic infection as potential participants with recent COVID-19-like symptoms or with a history of positive PCR test for SARS-CoV-2 were excluded from the study.
The authors say the participants recruited in this study will be followed-up for at least one year to continue to study the vaccine's safety and the immune response it provokes.
Writing in a linked comment discussing both articles, lead author assistant professor Naor Bar-Zeev (who was not involved in the two studies), International Vaccine Access Centre, Johns Hopkins Bloomberg School of Public Health, says: "These trial reports are hugely anticipated. The results of both studies augur well for phase 3 trials, where the vaccines must be tested on much larger populations of participants to assess their efficacy and safety… Both trials used adenovirus vectors to deliver and study the COVID-19 vaccine, an innovative and efficient means of vaccine development in the midst of a pandemic. Capable of generating humoral, cellular, and innate responses, adenovirus vectored vaccines have much potential."
However, he warns of the preliminary nature of the two vaccine candidates. He continues: "The platform [adenovirus vectored vaccines] only achieved European Commission regulatory licensure on July 1, 2020, with the Ebola vaccine. Much remains unknown about these and other COVID-19 vaccines in development, including longevity of response and immunogenicity in older adults or other specific groups, such as those with comorbidities who are often excluded from clinical trials, or ethnic or racial groups more severely affected by COVID-19."
STAT News reports that while the Oxford-AstraZeneca vaccine, known as AZD1222, has moved most rapidly into larger-scale studies of any major contender – and AstraZeneca has said that billions of doses could be manufactured – the new data represent the first glimpse researchers have gotten at its efficacy. They show a relatively safe vaccine – though side effects were greater than for a meningitis vaccine, to which it was compared – that engages the immune system to fight the virus. AstraZeneca said that, because of the results, it is likely that future studies will test giving patients two doses of the vaccine.
“At the end of the day, you have to prioritise efficacy and then resolve the challenges around the logistics of the trial or logistics of manufacturing large quantities of vaccine,” said Pascal Soriot, AstraZeneca’s CEO, in a briefing with reporters.
The report says The Lancet also published results of another vaccine, from the Chinese biotech CanSino, that had been previously released. The Phase 2 results showed that, as was seen in the Phase 1 data, the vaccine induced neutralizing antibody responses – which could be vital to preventing the disease’s dangerous symptoms – in most subjects. But further study continues to show that this vaccine works better in some people than others. And among those it didn’t work as well in were people aged 55 and older, a key target for COVID-19 vaccination.
“The results of both studies augur well for phase 3 trials, where the vaccines must be tested on much larger populations of participants to assess their efficacy and safety,” wrote Naor Bar-Zeev and William Moss, in the editorial.
Added Michael Ryan, the World Health Organisation’s health emergencies chief: “We now need to move into larger scale, real-world trials, but it is good to see more data, more products moving in to this very important phase of vaccine discovery.”
STAT News says the data on the Oxford-AstraZeneca vaccine do not provide enough information to predict whether it will be more effective than other vaccines that are also entering clinical trials.
AZD1222 is one of 23 potential COVID-19 vaccines that are being tested in clinical trials, according to the WHO. Studies in which thousands of volunteers are given either a vaccine or placebo are necessary to know for sure if any vaccine prevents infection with SARS-Cov-2, and how well that vaccine works. No such studies have been completed.
The report says in a paper also released Monday, BioNTech and Pfizer said their vaccine also induced T-cell responses.
But Mene Pangalos, an AstraZeneca executive vice president, warned during the company’s briefing that it is “almost impossible” to compare antibody levels between different vaccines because of variation in the tests used to measure them. He pointed out that AZD1222 has another advantage: it needs to be kept cold, but not frozen, as the messenger RNA vaccines do.
AZD1222, which was developed by researchers at Oxford’s Jenner Institute, works differently, by using a genetically engineered virus, called adenovirus, which was taken from chimps and modified not to replicate and sicken people. It carries a gene for one of the proteins in SARS-Cov-2 and inserts it into a recipient’s cells. The virus causes the patient’s cells to make that protein, which is then recognized by the immune system as foreign. This results in an immune response.
The report says the platform has not been used in an approved vaccine. But it has been used in experimental vaccines against the viruses that cause other outbreaks, including the Ebola virus and the virus that causes Middle East respiratory syndrome (MERS). That work left the Oxford group ready when SARS-CoV-2, a related virus, became a threat. Gilbert, who has been a key figure in developing the platform, known as ChAdOx1, said the data, though early, showed promise. “If our vaccine is effective, it is a promising option as these types of vaccine can be manufactured at large scale,” Gilbert said.
The report says CanSino, for its part, is now planning for a Phase 3 trial. Its vaccine is what’s known as a viral vector vaccine; it uses a live but weakened human cold virus, adenovirus 5 – known as Ad5 for short – as a delivery system that teaches the immune system to recognise the SARS-CoV-2 coronavirus.
Many people have had previous infections with adenovirus 5, raising concerns that the immune system would focus on the Ad5 parts of the vaccine rather than the SARS-Cov-2 material fused to it. Many research groups that work on viral-vectored vaccines stopped using Ad5 because of concerns about pre-existing immunity, which can run to 70% or higher in some populations.
The data released Monday showed subjects in the Phase 2 trial who had no or low-level pre-existing immunity to Ad5 developed neutralising antibodies to SARS-CoV-2 at roughly double the rate of people who had high-level pre-existing immunity. High-level pre-existing immunity was more common in people in the study aged 55 and older. The researchers said the vaccine’s response in older adults will be studied in a Phase 2b trial.
The report says the findings concern some experts.
Gary Kobinger, director of the Infectious Disease Research Centre at Laval University, Quebec, questioned whether it makes sense to pursue development of the vaccine, given the problem with pre-existing immunity to the Ad5 vector, and the relatively high rate of adverse events seen in the study. Most of the grade 3 reactions – the most severe – were seen in people who received the highest of two doses used in the study, though there was one report of a grade 3 fever in a person who received the lower dose. CanSino has dropped the higher dose.
But Kathryn Edwards, scientific director of the Vanderbilt Vaccine Research Programne in Nashville, noted the world is going to need as many COVID-19 vaccines as can be made. The CanSino vaccine may not be protective enough for older adults, she said, but it might be useful in children. To date the vaccine has only been studied in people 18 years and older.
The CanSino researchers suggested the dampening of the immune response due to pre-existing immunity to the Ad5 vector might be overridden by using a booster dose sometime between three and six months after the original dose – a potentially awkward dosing regimen that would not deliver rapid protection in the people who are at highest risk from COVID-19, older adults. Edwards said, though, that another dose might simply boost the immune response to the Ad5 vector, not the intended target, SARS-CoV-2.
The CanSino vaccine has already received an emergency license in China for use in the military.
Background: The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might be curtailed by vaccination. We assessed the safety, reactogenicity, and immunogenicity of a viral vectored coronavirus vaccine that expresses the spike protein of SARS-CoV-2.
Methods: We did a phase 1/2, single-blind, randomised controlled trial in five trial sites in the UK of a chimpanzee adenovirus-vectored vaccine (ChAdOx1 nCoV-19) expressing the SARS-CoV-2 spike protein compared with a meningococcal conjugate vaccine (MenACWY) as control. Healthy adults aged 18–55 years with no history of laboratory confirmed SARS-CoV-2 infection or of COVID-19-like symptoms were randomly assigned (1:1) to receive ChAdOx1 nCoV-19 at a dose of 5 × 1010 viral particles or MenACWY as a single intramuscular injection. A protocol amendment in two of the five sites allowed prophylactic paracetamol to be administered before vaccination. Ten participants assigned to a non-randomised, unblinded ChAdOx1 nCoV-19 prime-boost group received a two-dose schedule, with the booster vaccine administered 28 days after the first dose. Humoral responses at baseline and following vaccination were assessed using a standardised total IgG ELISA against trimeric SARS-CoV-2 spike protein, a muliplexed immunoassay, three live SARS-CoV-2 neutralisation assays (a 50% plaque reduction neutralisation assay [PRNT50]; a microneutralisation assay [MNA50, MNA80, and MNA90]; and Marburg VN), and a pseudovirus neutralisation assay. Cellular responses were assessed using an ex-vivo interferon-γ enzyme-linked immunospot assay. The co-primary outcomes are to assess efficacy, as measured by cases of symptomatic virologically confirmed COVID-19, and safety, as measured by the occurrence of serious adverse events. Analyses were done by group allocation in participants who received the vaccine. Safety was assessed over 28 days after vaccination. Here, we report the preliminary findings on safety, reactogenicity, and cellular and humoral immune responses. The study is ongoing, and was registered at ISRCTN, 15281137, and ClinicalTrials.gov, NCT04324606.
Findings: Between April 23 and May 21, 2020, 1077 participants were enrolled and assigned to receive either ChAdOx1 nCoV-19 (n=543) or MenACWY (n=534), ten of whom were enrolled in the non-randomised ChAdOx1 nCoV-19 prime-boost group. Local and systemic reactions were more common in the ChAdOx1 nCoV-19 group and many were reduced by use of prophylactic paracetamol, including pain, feeling feverish, chills, muscle ache, headache, and malaise (all p<0·05). There were no serious adverse events related to ChAdOx1 nCoV-19. In the ChAdOx1 nCoV-19 group, spike-specific T-cell responses peaked on day 14 (median 856 spot-forming cells per million peripheral blood mononuclear cells, IQR 493–1802; n=43). Anti-spike IgG responses rose by day 28 (median 157 ELISA units [EU], 96–317; n=127), and were boosted following a second dose (639 EU, 360–792; n=10). Neutralising antibody responses against SARS-CoV-2 were detected in 32 (91%) of 35 participants after a single dose when measured in MNA80 and in 35 (100%) participants when measured in PRNT50. After a booster dose, all participants had neutralising activity (nine of nine in MNA80 at day 42 and ten of ten in Marburg VN on day 56). Neutralising antibody responses correlated strongly with antibody levels measured by ELISA (R2=0·67 by Marburg VN; p<0·001).
Interpretation: ChAdOx1 nCoV-19 showed an acceptable safety profile, and homologous boosting increased antibody responses. These results, together with the induction of both humoral and cellular immune responses, support large-scale evaluation of this candidate vaccine in an ongoing phase 3 programme.
Funding: UK Research and Innovation, Coalition for Epidemic Preparedness Innovations, National Institute for Health Research (NIHR), NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and the German Center for Infection Research (DZIF), Partner site Gießen-Marburg-Langen.
Pedro M Folegatti, Katie J Ewer, Parvinder K Aley, Brian Angus, Stephan Becker, Sandra Belij-Rammerstorfer, Duncan Bellamy, Sagida Bibi, Mustapha Bittaye, Elizabeth A Clutterbuck, Christina Dold, Saul N Faust, Adam Finn, Amy L Flaxman, Bassam Hallis, Paul Heath, Daniel Jenkin, Rajeka Lazarus, Rebecca Makinson, Angela M Minassian, Katrina M Pollock, Maheshi Ramasamy, Hannah Robinson, Matthew Snape, Richard Tarrant, Merryn Voysey, Catherine Green, Alexander D Douglas, Adrian VS Hill, Teresa Lambe, Sarah C Gilbert, Andrew J Pollard, Oxford COVID Vaccine Trial Group
Background: This is the first randomised controlled trial for assessment of the immunogenicity and safety of a candidate non-replicating adenovirus type-5 (Ad5)-vectored COVID-19 vaccine, aiming to determine an appropriate dose of the candidate vaccine for an efficacy study.
Methods: This randomised, double-blind, placebo-controlled, phase 2 trial of the Ad5-vectored COVID-19 vaccine was done in a single centre in Wuhan, China. Healthy adults aged 18 years or older, who were HIV-negative and previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-free, were eligible to participate and were randomly assigned to receive the vaccine at a dose of 1 × 1011 viral particles per mL or 5 × 1010 viral particles per mL, or placebo. Investigators allocated participants at a ratio of 2:1:1 to receive a single injection intramuscularly in the arm. The randomisation list (block size 4) was generated by an independent statistician. Participants, investigators, and staff undertaking laboratory analyses were masked to group allocation. The primary endpoints for immunogenicity were the geometric mean titres (GMTs) of specific ELISA antibody responses to the receptor binding domain (RBD) and neutralising antibody responses at day 28. The primary endpoint for safety evaluation was the incidence of adverse reactions within 14 days. All recruited participants who received at least one dose were included in the primary and safety analyses. This study is registered with ClinicalTrials.gov, NCT04341389.
Findings: 603 volunteers were recruited and screened for eligibility between April 11 and 16, 2020. 508 eligible participants (50% male; mean age 39·7 years, SD 12·5) consented to participate in the trial and were randomly assigned to receive the vaccine (1 × 1011 viral particles n=253; 5 × 1010 viral particles n=129) or placebo (n=126). In the 1 × 1011 and 5 × 1010 viral particles dose groups, the RBD-specific ELISA antibodies peaked at 656·5 (95% CI 575·2–749·2) and 571·0 (467·6–697·3), with seroconversion rates at 96% (95% CI 93–98) and 97% (92–99), respectively, at day 28. Both doses of the vaccine induced significant neutralising antibody responses to live SARS-CoV-2, with GMTs of 19·5 (95% CI 16·8–22·7) and 18·3 (14·4–23·3) in participants receiving 1 × 1011 and 5 × 1010 viral particles, respectively. Specific interferon γ enzyme-linked immunospot assay responses post vaccination were observed in 227 (90%, 95% CI 85–93) of 253 and 113 (88%, 81–92) of 129 participants in the 1 × 1011 and 5 × 1010 viral particles dose groups, respectively. Solicited adverse reactions were reported by 183 (72%) of 253 and 96 (74%) of 129 participants in the 1 × 1011 and 5 × 1010 viral particles dose groups, respectively. Severe adverse reactions were reported by 24 (9%) participants in the 1 × 1011 viral particles dose group and one (1%) participant in the 5 × 1010 viral particles dose group. No serious adverse reactions were documented.
Interpretation: The Ad5-vectored COVID-19 vaccine at 5 × 1010 viral particles is safe, and induced significant immune responses in the majority of recipients after a single immunisation.
Funding: National Key R&D Programme of China, National Science and Technology Major Project, and CanSino Biologics.
Feng-Cai Zhu, Xu-Hua Guan, Yu-Hua Li, Jian-Ying Huang, Tao Jiang, Li-Hua Hou, Jing-Xin Li, Bei-Fang Yang, Ling Wang, Wen-Juan Wang, Shi-Po Wu, Zhao Wang, Xiao-Hong Wu, Jun-Jie Xu, Zhe Zhang, Si-Yue Jia, Bu-Sen Wang, Yi Hu, Jing-Jing Liu, Jun Zhang, Xiao-Ai Qian, Qiong Li, Hong-Xing Pan, Hu-Dachuan Jiang, Peng Deng, Jin-Bo Gou, Xue-Wen Wang, Xing-Huan Wang, Wei Chen
These data, along with phase I results on Moderna's mRNA vaccine published last week, all suggest that a vaccine – and perhaps more than one – to ameliorate the COVID-19 pandemic may soon be in reach. Looking ahead to phase III trial, which are planned for both these vaccine candidates, MedPageToday quotes Bar-Zeev and Moss note that they should be "rapid, pragmatic, and large enough to address efficacy in subgroups of interest."
Among the most pressing questions a phase III trial should answer include:
Whether a single dose is sufficient in older adults or a booster is required
Does longevity of response or rates of waning differ with a two-dose regimen?
Are there host-specific differences in immunogenicity by age, sex, or ethnicity?
Bar-Zeev and Moss also discussed the need for "pharmacovigilance infrastructure" to monitor the safety of these vaccines, including "surveillance for asymptomatic infection among vaccinated and unvaccinated persons" to determine risk of adverse vaccine outcomes, such as enhanced disease.
The WHO applauded the newly published data but cautioned that it’s still early and further evidence of its effectiveness is needed. CNBC quotes Ryan as saying there are 23 vaccine candidates in clinical development, and until Monday, only one had produced phase one data available in a peer-reviewed journal.
Once one of the vaccines are proven effective, the next challenge will be ensuring there are enough doses to distribute globally, he said. He noted “significant challenges and headwinds” to ensure the vaccines are scaled up to be supplied to as many people as possible.
“That mechanism as it presently stands is not going to be able to supply a vaccine for everybody on the planet,” he said. “We’re going to have to priorities who gets what vaccine at the beginning depending on which vaccine becomes available and we’re going to have to have some policy and priorities around the best use of those vaccines.”
The vaccine could still be ready by the end of the year if scientists can get 50,000 people in trials in the next six weeks, The Daily Telegraph reports experts have said. Initially, it had been hoped that a vaccine might be ready by September, but the number of COVID-19 cases plummeted in Britain after lockdown, meaning the chance of getting infected dropped substantially and making it difficult to test a vaccine.
Researchers were forced to move trials to South Africa and Brazil.
However, Professor Adrian Hill, the director of the Jenner Institute at the University of Oxford, said a jab could yet be ready by December if enough people could be recruited for trials by the beginning of September. "It's possible there will be a vaccine being used by the end of the year," he said. "What that needs is enough cases, probably about 50,000 people to be in trials by six weeks-time, including the very large US trial and to have an adequate incidence, and of course the vaccine has to work.
"But, you know, if it worked by early November – and it might be a little before that – you might have emergency use authorisation in a month, and then you would be deploying in December."
When it comes to protecting the world from the coronavirus, two doses of a vaccine may be better than one. But, Bloomberg Law reports, doubling the number of jabs each person needs could complicate efforts to immunise billions of people.
The latest results from front-runners in the sprint to come up with a vaccine highlight that prospect. Both efforts are conducting final-stage testing with two doses.
Producing vaccines and deploying them to the world’s population in the midst of a pandemic would be a huge challenge even if researchers are able to deliver one-dose inoculations. A need for two would make manufacturing and logistics even more complex.
The report says those challenges would get even tougher if – as some experts think is possible – a vaccine’s efficacy wanes over time and repeat doses are needed, potentially every year. “A one-shot vaccine would be ideal, but the first vaccines are highly unlikely to meet this very high threshold,” said Michael Kinch, a vaccine specialist and associate vice-chancellor at Washington University in St Louis. “As we hopefully move from whether there will be a vaccine to how to apply this, logistics are going to become the absolute most important topics.
Vaccine experts have warned that the first shots to gain approval against COVID-19 might not be the most effective or efficient. In fact, history shows two doses is a more likely scenario. Almost all standard vaccines are multiple-shot regimens, according to Tony Moody, an immunologist at the Duke Human Vaccine Institute. “We would like to do better, and we are all working to get to those better vaccines,” Moody said, “but having something effective soon is the top priority.”
Medical Xpress report
STAT News report
The Lancet abstract 1
The Lancet editorial
The Lancet abstract 2
Full MedPageToday report
Full CNBC report
Full report in The Daily Telegraph
Full Bloomberg Law report