Jes Hathaway is the editor in chief of National Fisherman magazine and NationalFisherman.com.
Written by Adrianne Madden
Friday, 07 September 2012
This week three groups who supported an Oregon ballot initiative to ban commercial gillnetting in the Columbia River have pulled their support from the ballot measure. They are instead throwing their weight behind Gov. John Kitzhaber's proposed solution to restrict fishermen using this gear type to off-channel areas. Ostensibly, this area closure would allow commercial fishermen to catch hatchery fish and reduce their catch of low-return wild salmon.
The tragic flaw of the ballot measure (#81) is that it does nothing to reduce fishing overall. First, it would simply allow recreational fishermen to exploit the same stocks through different methods and second, it would not restrict Washington-based gillnetters on their side of the river.
I don't understand the proclivity to eliminate jobs and entire communities on a whim or the misguided belief that one type of fisherman is better or worse than another type.
While I disagree that simply moving fishermen out of their historic fishing grounds is the best choice, I applaud the Association of Northwest Steelheaders, the Northwest Sportfishing Industry Association and the Northwest Guides and Anglers Association for moving away from an extreme stance by supporting Kitzhaber.
I urge the Coastal Conservation Association, Oregon Wild and the Humane Society to make moves toward reason and compromise, as well. Join industry and tribal groups, who also oppose the ballot measure, in a discussion, not a shutdown.
Come November, I hope the people of Oregon will vote with their hearts in support of their fellow citizens, jobs, community and history.
The American Fisheries Society is honoring recently retired Florida Institute of Oceanography director Bill Hogarth with the Carl R. Sullivan Fishery Conservation Award — one of the nation's premier awards in fisheries science - in recognition of his long career and leadership in preserving some of the world's most threatened species, advocating for environmental protections and leading Florida's scientific response to the Deepwater Horizon oil spill.Read more...
The Marine Stewardship Council has appointed Eric Critchlow as the new U.S. Program Director. Critchlow will be based in the MSC US headquarters in Seattle. He is a former vice president of Lusamerica Foods and has over 35 years in the seafood industry.Read more...


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Floriculture is the growing and marketing of flowers and foliage plant. It encompasses flower production, processing, marketing, and distribution.
The floriculture products include cut flowers and foliage, potted plants, bedding/garden plants, and propagation materials. The Floriculture sector is one of Uganda’s top ten foreign exchange earners contributing close to $ 30 million in export revenue. Uganda’s flowers are grown almost exclusively for the export market, with 98% of production exported to the Netherlands. Of this, 90% of the flowers are sold through the auctions and 10% are sold through direct sales, mainly to florists. The main types of flowers grown in the country are roses and cuttings.
How do you find this resource?

domain: agronomy


text:
Tuesday, June 12, 2007
a poem of a comment i posted at I talk news
thank you macieklew,
life is the dark side of the moon
people caricature pain
as a cartoon
i wonder whether after life
is a boon
some are born
some without feet
some with mouths
holding golden spoons
the world terrorised
at the mercy of political goons
God was confused he did not know whether to make me a Hindu Sufi Shia Christian or Jew He mixed all the colors made a color new.. He ad...
Shah-e-Mardan Sher-e-Yazdan Quwat-e-Parwardigar Lafata Ila Ali La Saif Ila Zulfiqar , originally uploaded by firoze shakir photographerno1 ....
Ek Shahenshah Ne Banake Yeh Haseen Tajmahal Ham Gareebon Ki Mohabbat Ka Udaya Hai Mazak.. , a photo by firoze shakir photographerno1 on Fli...
Dargah of Hazrat Syed Ali Mira Datar Unava Gujrat , a photo by firoze shakir photographerno1 on Flickr. HAZRAT SYED ALI MIRA DATAR'S G...

domain: artistic


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An Evening with Tracey Thorn and launch of the paperback of her memoir Another Planet: A Teenager in Suburbia
An evening with Tracey Thorn and launch of paperback of her best-selling memoir Another Planet: A Teenager in Suburbia; follow-up to Bedsit Disco Queen.
Tracey Thorn is an acclaimed musician and writer, best-known for her seventeen years in bestselling duo ‘Everything But the Girl’, with Hull alumni Ben Watt and named after a Hull furniture store. Tracey graduated from the University of Hull’s English Department in 1984 with a first class degree and an exciting and successful music career already in place.
Since then she has released four solo albums, one movie soundtrack, several singles and three books including the Sunday Times best-selling memoir Bedsit Disco Queen. She has judged the Women’s Prize for Fiction and the Goldsmith’s Prize and currently writes for the New Statesman.
Tracey returns to her alma mater to talk about the music business, writing and the city and university from which she and Ben launched their brilliant musical and writing careers.

domain: entertainment


Originating in Tunisia and spreading rapidly to Egypt, Yemen, Bahrain, and Libya, the recent wave of popular movements that the Western media have dubbed the “Arab Spring” has been closely monitored by the whole world including in Turkey. This country is geographically close to the region and the ruling Justice and Development Party (AKP) has been active in developing foreign policies in relation to the key countries involved. This paper analyzes the news discourses in the reports published between January 25th and February 25th, 2011, in six Turkish national newspapers. This is the period when upheaval reached its peak in Tahrir Square in Cairo, the most potent symbol of “Arab Spring”. The newspapers sampled fall into two categories, those supporting the AKP government (Star, Zaman, and Sabah) and those not supporting the AKP government (Cumhuriyet, Hürriyet, and Taraf). To map the discursive fields employed in the news reports, this paper draws on methods from critical discourse analysis and examines news actors and their quotation patterns, lexicalization, overlexicalization and syntactic preferences.


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A young girl could go into care after doctors raised concerns that her body mass index was too high.
The 12-year-old had been in the care of her mother but when the issue was raised she was taken into foster care.
Now bosses at an unspecified council's social services team have started litigation at Leicester Family Court .
A judge will make a decision in the near future.
Detail of the case has emerged in a ruling by Judge Clifford Bellamy, who analysed preliminary issues at a private family court hearing.
Judge Bellamy said no-one involved could be identified.
A doctor had examined the girl a few months ago and concluded her body mass index was at a "dangerously high level" , said the judge.
The youngster had gone into foster care pending decisions about her long-term future.
Judge Bellamy said medical experts would give evidence relating to concerns about the youngster's obesity before decisions about where she should live were made.
To download the IOS app click here .
To download the Android app click here .

domain: news


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Q2Pay is a platform that allows large corporates to automate and manage their nationwide payments to vendors.
- Bank Draft
- Vendor is shortlisted.
- Payment terms are agreed.
- Vendor is enrolled and allotted vendor ID in your ERP.
- Invoices are uploaded to your ERP.
- Payment is made by Cheque/Bank draft/NEFT/RTGS.
- For timely payments to be made your current account needs to have sufficient balance or
- Bank credit line or Overdraft facility needs to be available.
Many a times
Vendor Payments often get delayed resulting in unhappy and disgruntled Vendors which boils down to delay in receiving raw materials, products and services which leads to further inefficiencies.
Q2Pay web based solution will allow payments to be made using Credit Cards.
Why this can't be done currently
- To make payment using Credit Card the vendor has to have a merchant ID.
- The Vendor has to have the capability to accept card payment using a POS (point of sale) terminal or a website that has an online payment gateway.
- POS terminal requires physical interaction and swiping of the card.
- The vendors receiving payment don't need to have any Merchant ID.
- The vendors don't need card processing capability nor POS terminal.
- The payment will be credited to Vendors account with any bank in the country.
- The system has the capability to interface with your ERP.
- The system has the capability to make payments to vendors batch wise or individually, collectively or selectively using one or combination of cards.
- The system has capability to given reverse data feed to your ERP of payments made, denied, on-hold etc.
Benefits for your organization
- Extended Credit Period : Extended payment terms with choice of card billing cycles.
- Increased Savings : Opportunity to operate at a lower working capital cost.
- Safety & Controls : Robust payment controls to avoid card misuse.
- Reduced Paperwork : Service Provider arrangement with corporate eliminates paperwork for vendor enrollment.
- Comprehensive Reports : Detailed reporting on supplier payments, credit period, savings etc.
- Enhanced Data : Enhanced data capture like PO No., Invoice No., Cost Centre etc. on Axis statement for audit & recon purpose.

domain: finance


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The Federal Aviation Administration says Chicago’s airports are nearing normal activity after a fire at an air traffic control center last week brought flights to a halt.
The FAA said Tuesday morning that data through midnight showed air traffic flow at O’Hare International Airport was at more than 80 percent of last Monday. It was about 90 percent at Midway International Airport.
A Naperville man is charged in federal court with setting a fire Friday at an Aurora control center and then trying to kill himself. The damage caused more than 2,000 flights to be canceled, disrupting travel nationwide.
The FAA has said it estimates the airports will be a full capacity in about two weeks.


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AR-15 Plastix Plus 6" Single Post Wall Mount with double Mag storage.
You may never have had to grab your rifle to protect your home or family and hopefully you never will. However if you needed to, are you ready to react fast but still have your rifle stored in a responsible manner.
Keep your AR-15 safe and secure but ready for fast access. Your AR rifle display wall mount uses the mag release button for mount lock/unlock.
Made of High Density Polyethylene Thermoplastic making it impervious to corrosion, fading and chemicals while mounting with heavy duty mounting hardware (not included) to your wall.
Made in the USA.
Due to the products popularity please allow up to three weeks to ship.
The single post AR-15 wall mount works great. Hids my AR in the closet when not at the range
Funny that the dense plastic has welds, but guessing that is from the metal prototype used for a 3-D printer for production.
Wanted to mount my AR15 and this works great.

domain: design


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The co-primary objectives of this study were to determine the human pharmacokinetics (PK) of oral NR and the effect of NR on whole blood nicotinamide adenine dinucleotide (NAD+) levels.
Though mitochondrial dysfunction plays a critical role in the development and progression of heart failure, no mitochondria-targeted therapies have been translated into clinical practice. Recent murine studies have reported associations between imbalances in the NADH/NAD+ ratio with mitochondrial dysfunction in multiple tissues, including myocardium. Moreover, an NAD+ precursor, nicotinamide mononucleotide, improved cardiac function, while another NAD+ precursor, nicotinamide riboside (NR), improved mitochondrial function in muscle, liver and brown adipose. Thus, PK studies of NR in humans is critical for future clinical trials.
In this non-randomized, open-label PK study of 8 healthy volunteers, 250 mg NR was orally administered on Days 1 and 2, then uptitrated to peak dose of 1000 mg twice daily on Days 7 and 8. On the morning of Day 9, subjects completed a 24-hour PK study after receiving 1000 mg NR at t = 0. Whole-blood levels of NR, clinical blood chemistry, and NAD+ levels were analyzed.
Oral NR was well tolerated with no adverse events. Significant increases comparing baseline to mean concentrations at steady state (Cave,ss) were observed for both NR (p = 0.03) and NAD+ (p = 0.001); the latter increased by 100%. Absolute changes from baseline to Day 9 in NR and NAD+ levels correlated highly (R2 = 0.72, p = 0.008).
Citation: Airhart SE, Shireman LM, Risler LJ, Anderson GD, Nagana Gowda GA, Raftery D, et al. (2017) An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS ONE 12(12): e0186459. https://doi.org/10.1371/journal.pone.0186459
Editor: David A. Sinclair, Havard Medical School, UNITED STATES
Received: October 19, 2016; Accepted: September 30, 2017; Published: December 6, 2017
Copyright: © 2017 Airhart et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: All relevant data are within the paper and its supporting information files.
Funding: This work was supported by HL126209-01S1, nhlbi.nih.gov, KDO and RT; HL110349, nhlbi.nih.gov, RT; UL1TR000423, ncrr.nih.gov; P30DK035816, niddk.nih.gov; 15POST22560002, heart.org, SEA and KDO.
Competing interests: The authors have declared that no competing interests exist.
Mitochondrial dysfunction has been implicated in multiple diseases, including heart failure [1–3]. However, there currently is no specific treatment for mitochondrial dysfunction in human heart failure or any other disease [4–7]. In recent years, there has been a surge of interest in targeting alterations in energy metabolism in heart failure. Development of mitochondria-based therapies for metabolic diseases has been hampered both by limited understanding of how mitochondrial impairment causes tissue dysfunction as well as by a lack of interventions shown to improve mitochondrial function. Recently, we demonstrated in a murine model that impaired mitochondrial oxidative phosphorylation led to an increased myocardial NADH/NAD+ ratio and increased mitochondrial protein acetylation without affecting mitochondrial production of reactive oxygen species (ROS) or synthesis of adenosine triphosphate (ATP) . These changes rendered the heart susceptible to chronic stresses, which accelerated the development of heart failure. Similar increases in the NADH/NAD+ ratio and in protein acetylation also were seen in animal models of heart failure due to chronic pressure overload. Furthermore, intraperitoneal administration of the NAD+ precursor nicotinamide mononucleotide (NMN) to these mice normalized the NADH/NAD+ ratio, prevented the increase in mitochondrial protein acetylation, and improved cardiac function . Promoting NAD+ synthesis through the salvage pathway by overexpressing nicotinamide phosphoribotransferase protected against ischemia-reperfusion injury and ischemic heart failure [10, 11]. These findings collectively suggest that augmentation of NAD+ could improve mitochondrial function and exert myocardial protection.
Nicotinamide riboside (NR) is a pyridine nucleoside form of vitamin B3 that is naturally found in milk and is available as a nutraceutical. NR is converted by nicotinamide riboside kinases (NRK1,2) to NMN, which is subsequently converted to NAD+ by nicotinamide mononucleotide adenylyltransferase (NMNAT). Oral supplementation with NR has been shown to increase NAD+ in brown adipose tissue, skeletal muscle and liver, and to improve mitochondrial function in a mouse model of diet-induced obesity . Nutritional supplementation with NR, an NAD+ precursor, thus holds potential as an innovative therapy for heart failure and other disease states characterized by mitochondrial dysfunction. However, very limited information is available in regard to whether NR supplementation augments NAD+ levels in humans. Therefore, the primary objective of this study was to determine the pharmacokinetics of orally administered NR and its ability to increase blood NAD+ in healthy subjects following dose escalation of NR to 1000 mg twice daily. Primary outcomes were comparisons of baseline concentrations versus mean concentrations at steady state (Cave,ss) on Day 9 for NR and NAD+. Secondary outcomes were to determine the safety and tolerability of NR by assessing adverse event rates and comparisons of laboratory tests, specifically serum levels of potassium, creatine kinase (myositis), glucose (insulin resistance), uric acid and alanine aminotransferase.
The first participant was enrolled on November 4, 2015, and the final participant completed all study follow-up visits on December 23, 2015. Fourteen potential participants responded to a posting on the University of Washington (UW) Institute of Translational Health Sciences community volunteer forum (https://www.iths.org/community/for-volunteers-patients/). Five subsequently declined to participate and one was excluded due to anxiolytic medication use. Flow of participants through the Study is shown in Fig 1.
The remaining eight healthy volunteers (6 female, 2 male, age range 21–50 years) met all inclusion criteria and provided informed consent. None had any exclusion criteria, which included current smoking, pregnancy (i.e., positive urine pregnancy screening test in applicable females just prior to enrollment), current use of any medications or supplements (with the exception of birth control), any history of liver, renal, cardiovascular, endocrine or neurological disease, known allergy to niacin or nicotinamide riboside, or not being able to refrain from drinking alcohol during the duration of the study. All eight participants received the allocated intervention (NR), and all eight participants completed all Study procedures and follow-up. No participants were excluded from analyses. The standardized method for characterizing adverse events employed in the UW Clinical Trials Unit is the Common Terminology Criteria for Adverse Events v3.0 (CTCAE). There were no protocol deviations.
All research involving human participants was approved by the University of Washington Institutional Review Board (IRB) on August 4, 2015, and all clinical investigation was conducted according to the principles expressed in the Declaration of Helsinki. Written informed consent was obtained from all participants.
Nicotinamide riboside: Source and administration schedule
NR was supplied as 250 mg capsules by the manufacturer (Niagen®, ChromaDex, Irvine, CA). NR was manufactured in a GMP-compliant facility according to ISO/IEC 18025:2005 standards. Two Certificates of Analysis provided by the manufacturer and performed on separate lots reported ~99% purity of the NR preparation. In addition, an independent analysis was performed at the University of Washington on NR (Niagen®) purchased online (Amazon Prime, Amazon.com, Inc., Seattle, WA) by the investigators; 1H-NMR spectroscopy of this NR demonstrated 98–99% purity (Fig 2).
NMR signals that arise from NR are labeled with the corresponding location of the hydrogen atom(s) as shown in the molecular structure of NR (inset). TSP [3-(trimethylsilyl)propionic acid-2,2,3,3-d4 sodium salt] was used as an internal standard to quantify the amount and purity of NR in the capsules. The purity of NR was calculated based on integration of all the peaks and was in the range of 98–99%.
All participant clinic visits, medication dispensing and data collection were performed on the General Clinical Research Center (GCRC) at the University of Washington (UW). NR was self-administered by participants orally at 250 mg daily on Days 1 and 2, 250 mg twice daily on Days 3 and 4, 500 mg twice daily on days 5 and 6, and 1000 mg twice daily on Days 7 and 8. Once daily dosing was self-administered at approximately 8am. Twice daily dosing was self-administered at approximately 8am and 8pm.
On the morning of Day 9, participants were admitted to the UW GCRC for a 24-hour pharmacokinetic study. Participants were administered the final NR dose of 1000 mg at t = 0 by UW GCRC staff.
Blood samples were obtained to monitor for potential side effects of NR therapy following 6-hour fasts and prior to NR dosing at baseline (Day 1) and on Days 2 and 9. Laboratory tests on these samples included complete blood count with white blood count differential and platelets, a serum chemistry panel (sodium, potassium, chloride, glucose, blood urea nitrogen, and creatinine), creatine kinase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), uric acid, and lactate dehydrogenase.
NR and NAD+ concentrations were determined in blood samples drawn on Day 1 as well as in samples obtained on Day 9 at the following times after the last 1000 mg NR dose: 0.5, 1, 2, 3, 4, 6, 8, 12, 16, and 24 hours. Due to the reported presence of low levels of NR in milk, standardized meals devoid of milk and dairy products were provided during the 24-hour pharmacokinetic study.
NR and NAD+ assays were performed by the Pharmacokinetics Lab in the UW Department of Pharmaceutics. All other blood assays were performed by the Analytical Core of the UW Nutrition Obesity Research Center (NORC).
The study protocol followed the ethical standards of the University of Washington in accordance with the Helsinki Declaration of 1975 as revised in 1983. Recruitment for this study was conducted according to the Institutional Review Board (IRB) policies at the University of Washington, as well as Health Insurance Portability and Accountability Act (HIPAA) policies. All participants provided written, informed consent. The study has been registered on www.clinicaltrials.gov (Identifier: NCT02689882). A Data Safety Monitoring Board (DSMB) monitored ongoing safety of study participants. Safety monitoring included pre-specified evaluation for hyperkalemia, as well as for evidence for myositis (creatine kinase), dysglycemia (glucose), gout (uric acid), and hepatotoxicity (alanine aminotransferase). The DSMB reviewed participant-level and summary data at two time points: after study completion by the first 5 participants and again at end-of-study.
Analysis of NR and NAD+ in whole blood
Acid citrate-dextrose (ACD) solution was purchased from Sigma-Aldrich (St. Louis, MO). The following reagents of analytical grade or higher were obtained from Sigma-Aldrich: NAD+, NMN, 8-bromoadenosine-5’-monophosphate (BMP), bovine serum albumin (BSA), citric acid, trichloroacetic acid, ammonium acetate, ammonium formate, methanol, and acetonitrile. The chloride salt of NR was purchased from ChromaDex, Inc. (Irvine, CA; Catalog #: ASB-00014313-001), and d4-NR triflate was purchased from Toronto Research Chemicals (Toronto, ON; Catalog #: N407772).
Blood sample collection.
For NR analysis, 0.5 mL whole blood was transferred within 3 minutes after blood draw to a storage tube containing 0.070 mL ACD solution (22 g/L citric acid, trisodium salt; 7.3 g/L anhydrous citric acid; and 24.5 g/L D-(+)-glucose), 0.010 mL 2.5 M citric acid, and 200 ng of the internal standard, d3-NR. The mixture was vortexed briefly and immediately inserted into dry ice pending transfer to long-term storage at -80°C. For NAD+ analysis, whole blood was collected in Vacutainer® tubes containing 0.105 M buffered sodium citrate (BD Diagnostics, Franklin Lakes, NJ), immediately placed on wet ice, and transferred to a -80°C freezer generally within 5 minutes after collection. Replicate aliquots were prepared and stored for each analysis to avoid the need for repeated freezing and thawing of the blood samples.
Assay procedure for NR.
Calibration standards were prepared by adding known amounts of NR (2.5 ng to 20 ng) to tubes containing a solution of ACD, citric acid, and the internal standard d4-NR; 0.5 mL thawed frozen human blood was then added to each standard tube to achieve a final NR concentration range of 0.0195 μM to 0.156 μM. During preparation, all tubes were kept on wet ice. A 50 μL aliquot of each calibration standard was combined with 0.3 mL of 4% TCA, vortexed well, and put back on wet ice. Blood samples from the study were thawed quickly, one at a time, and then mixed well by vortexing. Fifty μL of each study sample were immediately combined with 0.3 mL of 4% TCA, vortexed and placed on wet ice. After protein precipitation was completed in all samples, the tubes were vortexed again and centrifuged for 10 minutes at 4°C and ~20,000 rcf. The supernatants were transferred to Costar Spin-X 0.22 μm spin filters (Corning; Corning, NY) and centrifuged for 1 minute at 4°C and ~20,000 rcf. The eluates were placed in a 96-well plate and 5 μL aliquots were injected onto an Agilent 1290 series ultra-performance liquid chromatograph coupled to an Agilent 6410 triple-quadrupole mass spectrometer (Agilent Technologies, Palo Alto, CA). Chromatographic separation of the analytes was achieved using a HyperCarb 100 x 2.1 mm, 5 μm particle-size column (Thermo Scientific). Mobile phase A was 10 mM ammonium formate, pH 3.5, and mobile phase B was methanol. The flow rate was 0.3 mL/min. The elution gradient started at 12.5% B, increased linearly to 15% B from 0.5 min to 1 min, then increased to 29% B by 2.5 min, and held at 29% B until 7.5 min. The mass spectrometer operated in electrospray ionization mode with positive polarity. The following ion transitions were monitored: 255.1 → 123.1 (NR) and 258.1 → 126.1 (d3-NR) m/z. The fragmentor voltage was set to 83 V, and the collision energy was 8 V. The capillary voltage was 1000 V.
Assay procedure for NAD+.
An aliquot of frozen blood sample was thawed in a 30°C water bath for approximately 2 minutes; only 1–2 samples were thawed at a time. As soon as the blood had thawed, 50 μL were added to tubes containing 1 μg BMP as the internal standard and immediately followed by 300 μL of 4% trichloroacetic acid to precipitate proteins. Calibration standards were similarly prepared except that the matrix was 30 mg/mL BSA spiked with NAD+ and NMN that had been dissolved in methanol. After protein precipitation, the samples were centrifuged in a benchtop microcentrifuge at ~20,000 rcf for 10 minutes at 4°C. The supernatants were loaded onto Costar Spin-X 0.22 μm spin filters and centrifuged again at ~20,000 rcf for 1 minute at 4°C. The eluates were placed in a 96-well plate and injected onto an Agilent 1100 series high performance liquid chromatograph coupled to an Agilent G1956B single-quadrupole mass spectrometer. Chromatographic separation of the analytes was achieved using a HyperCarb 100 x 2.1 mm, 5 μm particle size column (Thermo Scientific). Mobile phase A was 100 mM ammonium acetate, pH 8.5, and mobile phase B was acetonitrile. The flow rate was 0.3 mL/min. The elution gradient started at 5% B, increased linearly to 30% B from 0.5 min to 4 min, held at 30% B until 6 min, then increased to 50% B by 8 min, held at 50% B until 9 min, then increased to 80% B by 9.5 min, held at 80% B until 10.5 min, then decreased to 5% B by 10.6 min, and the column was equilibrated at 5% B until 15 min post injection. The mass spectrometer was operated in electrospray ionization mode with positive polarity. Ions monitored were 664.1 (NAD+), 335.1 (NMN), and 425.9 (BMP) m/z. The fragmentor voltage was set to 120, 110, and 110 V for NAD+, NMN, and BMP, respectively. The capillary voltage was 3000 V.
For analyte calculations, the peak height ratios of NAD+/BMP, NMN/BMP, and NR/d3-NR were used, and the standard curves were fit to a second-order polynomial. The lower limit of quantitation (LLOQ) of NAD+, defined as the lowest standard with accuracy within ± 10% of actual value and precision with coefficient of variation < 10%, was 2.3 μM. The LLOQ of NMN was 1.5 μM, and the LLOQ of NR was 0.0156 to 0.0195 μM. Run-to-run quality control samples were considered to be acceptable when accurate to within ± 10% of expected concentration.
A descriptive (non-compartmental) approach was used for the pharmacokinetic analysis of blood NR and NAD+ concentration-time data. The area under the blood concentration-time curve was calculated for each subject using the linear trapezoidal rule. The average concentration at steady state (Cave,ss) was calculated by dividing the AUC0-12 hrs by the dosing interval of 12 hours.
Participant characteristics and baseline clinical laboratory data are presented as mean ± standard deviation (SD). Paired Student’s t tests assuming unequal variance were used to compare 1) baseline and Day 9 Cave,ss values, 2) baseline and trough concentrations, and 3) baseline and peak concentrations for NR and NAD+. Similar statistical methods were used to compare baseline and Day 9 values for five secondary endpoints (serum levels of potassium, creatine kinase, glucose, uric acid and aspartate aminotransferase), as well as for ten additional variables of interest (systolic and diastolic blood pressures, body temperature, body weight, white blood cell count, hematocrit, hemoglobin, platelets, and serum levels of lactate dehydrogenase and alanine aminotransferase).
To calculate the correlation of changes in NAD+ concentrations with the NAD+ levels at baseline, the square of the Pearson correlation coefficient (R2) was calculated for (NAD+ Cave,ss − NAD+ baseline concentration) vs. NAD+ baseline concentration. Similarly, the correlation of changes in concentrations of NR and NAD+ were calculated as the square of the Pearson correlation coefficient for (NR Cave,ss − NR baseline concentration) vs. (NAD+ Cave,ss − NAD+ baseline concentration).
All eight enrolled participants completed the study. Participants were (mean ± SD) 33 ± 8 years of age and 75% female with the following self-reported ethnic distribution: 75% non-Hispanic white, 12.5% Asian and 12.5% African American.
Safety assessments and other variables
No adverse events or side effects attributable to NR were reported during dose escalation of NR to 1000 mg orally twice daily.
Pre-specified laboratory safety endpoints were designed to evaluate possible laboratory abnormalities that might be seen with NR based on previous studies with NR (i.e., hyperkalemia) or that have been reported with either niacin and/or nicotinamide (i.e., myositis, hyperglycemia, hyperuricemia and hepatotoxicity). As shown in Table 1, no clinically significant changes were seen in any of the five pre-specified safety endpoints, i.e., potassium, creatine kinase, glucose, uric acid and alanine aminotransferase. Serum potassium decreased by an average of 0.4 mEq/L, which was statistically significant (p = 0.015) but the individual levels remain in normal range.
Parameter values reported as mean ± standard deviation.
As shown in Table 2, a slight though statistically significant decrease was seen for hematocrit (mean difference = –2%, p = 0.005), hemoglobin (–0.4 g/dL, p = 0.04), and platelet count (–20,000/μL, p = 0.03). There were no significant changes in blood pressure, body temperature, body weight, white blood cell count, lactate dehydrogenase or aspartate aminotransferase. In addition, there were no significant changes in serum levels of sodium, chloride, urea nitrogen, creatinine, or in white blood cell differential (data not shown).
Development of collection and processing methods for assay of NR and NAD+ in whole blood
During assay development before starting the study, NR was found to be highly unstable in blood, although the combination of 2.5 M citric acid and ACD solution improved NR stability in blood. At room temperature, the absolute peak heights of NR and the deuterated internal standard spiked into blood and processed as described in the methods section decreased by 8% to 14% over 30 min, but their ratios remained constant. While the latter observation means quantitation relying on signal ratio between analyte and internal standard is feasible in the event of ex vivo degradation or consumption, the decrease in absolute signal does limit our assay sensitivity (i.e., LLOQ). At the temperature of wet ice, spiked NR and deuterated internal standard appeared stable for 20 min, but decreased by 22% in 1 hour. This led to our current practice of processing the blood samples immediately to limit the lapse between blood draw and stabilization to < 5 min. NR in the sample becomes stable once blood proteins are precipitated, which allowed us to process the samples on the LC-MS/MS over the required run time. Also, storage data thus far indicate that NR blood samples are stable at –80°C for at least 3 weeks. With the resolution of NR’s instability problem, we were able to generate for the first time pharmacokinetic data on NR in human subjects.
It should also be noted that we did try to measure NR in the plasma fraction of a few blood samples obtained from volunteers following ingestion of NR, but failed to detect measurable levels of the riboside. We concluded that NR is concentrated in the cellular fraction of blood. Because NR’s instability in blood ex vivo, we decided to avoid the delay in separating cells from blood samples, and instead assay whole blood concentration.
Similar to NR, NAD+ is unstable in blood samples at room temperature. Measured levels of NAD+ spiked into thawed, room-temperature whole blood degraded by as much as 50% in 10 minutes. NAD+ degraded at a much slower rate (~3–4% decrease in 10 minutes) when blood samples were placed on wet ice. Also, NAD+ is stable in blood when stored at –80°C for at least 3 weeks. Hence, blood samples collected for NAD+ analysis were immediately placed on wet ice and then frozen in dry ice within 5 minutes of collection. Once blood proteins were precipitated with TCA, NAD+ in the supernatant remained stable for at least 48 hours while the samples were being processed on the LC-MS. Also, instability, at least over a few hours, was not observed when NAD+ was spiked into BSA rather than blood, suggesting that the disappearance of signal is not due to chemical instability.
Pharmacokinetics of NR in whole blood
Measurable levels of endogenous NR were observed in blood collected on Day 1 prior to treatment with NR supplement; basal levels of NR varied by 2.1-fold between the 8 subjects, from 0.0156 to 0.0336 μM (Fig 3).
Each subject is depicted in a different color with time points connected by a line. The y-axis depicts NR and NAD+ concentrations in μM, and the x-axis depicts values on Day 1 (baseline) and then time post-dose in hours on Day 9. The baseline time point was collected pre-dose on Day 1 of the trial.
All but one subject showed an increase in blood NR concentration from baseline to the Day 9 trough level with percent NR changes from baseline ranging from –10% to +127%. Following the Day 9 dose, the increase in blood NR concentration peaked at t = 3 hours (Fig 2) in half of the participants, while the other half had no obvious change in blood NR levels. The pharmacokinetics of blood NR appeared to have reached a steady state by the Day 9 dose (i.e., within two days of dosing at 1000 mg twice daily), as the trough NR level prior to the last dose was similar to the 12 hour post-dose NR level (0.031 ± 0.008 μM vs. 0.027 ± 0.004 μM, p = 0.1). For the four subjects with distinct Cmax, the mean blood NR concentration showed an exponential or log-linear decline from t = 3 hours to t = 12 hours, which afforded a regression estimate (± the standard error of the regression) for a first-order elimination rate constant of 0.26 ± 0.04 hr-1 and a corresponding half-life of 2.7 hours.
To index the overall increase in blood NR concentration after the Day 9 dose compared to the baseline level, we calculated an average steady-state blood concentration based on the area under the blood concentration-time curve over the 12-hour dosing interval (i.e., Cave,ss). The Cave,ss of NR was higher than baseline in seven of eight participants (mean difference = 0.014 μM, p = 0.03) (Fig 4).
Each subject is depicted in a different color and the time points are connected by a line. The p value for a paired Student’s t test is shown in the upper left corner of each plot.
Changes from baseline levels for NR are shown for Cave,ss and two other pharmacokinetic variables (Baseline vs. Trough and Baseline vs. Peak) in Table 3. Peak concentrations were also significantly higher than the baseline concentration at the 95% confidence level (mean difference = 0.030 μM, p = 0.04).
Increase in steady-state blood NAD+ levels in response to NR
In the 8 participants, the mean circulating level of NAD+ at baseline (Day 1) was 27 ± 6 μM, consistent with values reported previously in healthy subjects [15, 16]. Nicotinamide adenosine dinucleotide (NADH) was not detected in blood. Nicotinamide mononucleotide (NMN), a known immediate precursor of NAD+, was detected in baseline (Day 1) blood samples of all subjects but was at or just above the assay lower limit of quantitation.
Notable elevations in blood NAD+ concentrations were seen on Day 9 compared to baseline on Day 1 in every subject (Fig 3). Cave,ss for blood NAD+ was, on average, about 2-fold higher than baseline (range 1.34- to 2.66-fold), with a mean increase of 26.7 μM (p = 0.001). As a group, the rise in blood NAD+ (calculated as Cave,ss − baseline) following NR treatment did not correlate with the baseline blood level on Day 1 (R2 = 0.27, p = 0.2). It should also be noted that blood NMN concentration did not show a measurable increase from baseline in any of the samples collected on Day 9 (data not shown). Trammell et al.  have also reported low levels of NMN in PBMCs of 12 healthy human subjects after single oral doses of NR at 100, 300 and 1000 mg; the mean maximum concentration at the 1000 mg dose was 2 μM (below the LLOQ of our assay) and was not significantly different from baseline.
Changes in blood NR and NAD+ concentrations were correlated highly across the 8 subjects, with a Pearson correlation coefficient of 0.85 (R2 = 0.72, p = 0.008) (Fig 5).
Each subject is plotted as a different color. The blue line shows a linear regression of the change in NAD+ given the change in NR, and the shaded area shows the 95% confidence interval of that regression.
Interestingly, while the Day 9 trough blood levels of NAD+ increased as compared to baseline in each of the eight participants, there was no observable further increase in blood NAD+ concentrations after the last dose of NR, i.e., measured NAD+ levels remained relatively constant during the 24-hour pharmacokinetic monitoring period.
This pilot study yielded several important findings. First, successful and reliable methods for collection, processing and measurement of NR and NAD+ in human blood were developed, overcoming the severe instability problems that have prevented previous investigations into the clinical pharmacokinetics of NR in blood or tissue. These methods allowed us to determine the pharmacokinetic profile of orally administered NR in healthy human volunteers.
Second, the study demonstrated that an NR dose of 1000 mg twice daily significantly increased steady-state, whole-blood levels of NAD+ in all study participants with individual increases ranging from 35–168% above baseline NAD+ levels.
Finally, the study demonstrated that measurable, biologic effects on NAD+ levels can be achieved in healthy volunteers at NR doses that are well-tolerated. Specifically, participants reported none of the serious side effects seen with similar doses of niacin, such as flushing, pruritus, hyperglycemia, hyperuricemia, or elevations in liver or muscle enzymes [17, 18]. Together, these findings support the feasibility of studying NR as a potential therapy for diseases in which mitochondrial dysfunction has been implicated.
At the time of our manuscript submission, Trammell et al.  reported a similar study on NAD+ metabolome in peripheral blood mononuclear cells (PBMC) in twelve healthy human subjects after single oral ingestion of NR at three different dose levels: 30, 100 and 1000 mg. Their findings are consistent with our experience and observations after 9 consecutive days of NR treatment at a final daily dose of 1000 mg. Over the 36 days of observation, Trammell et al. did not observe any serious adverse event and any event that was dose-related. Mean PBMC NAD+ concentration at 24-hours for pooled data across all three dose levels was significantly elevated compared to pre-dose concentration (p ≤ 0.03). Peak PBMC NAD+ concentrations rose by an average of 4 ± 2 μM at the 100 mg NR dose and reached a plateaued response average of 6.5 ± 3.5 μM at 300 and 1000 mg doses from a baseline average of 12 ± 3.3 μM. PBMC NAD+ concentrations for the 1000 mg dose reported by Trammell et al. are within range of the whole-blood NAD+ concentrations observed in this study. More importantly, the magnitude of increase in PBMC NAD+ concentration reported by Trammell et al. after a single 1000 mg dose of NR is quite comparable to our observed peak whole-blood concentration (see Table 2) after dose escalation to two final days of NR treatment at 1000 mg (+54% vs. 67%). It should be noted that Trammel et al. also profiled the NAD+ metabolomics in blood and urine collected from one male, 57-year old subject, who ingested 1000 mg of NR daily for 7 days. PBMC NAD+ concentration rose by 2.7-fold in this one subject, which matches the maximum increase in whole-blood NAD+ concentration we observed in our subjects. Trammell et al. did not include NR in their PBMC metabolome measurements.
There are a few additional findings with our NR and NAD+ data that warrant comment. The current study demonstrates that the apparent oral bioavailability of a 1000 mg dose of NR was highly variable among individuals. While half of the participants showed a significant increase (≥ 100%) in peak blood NR concentration during the pharmacokinetic portion of the study, the remaining subjects showed no or only modest (≤ +50%) changes in blood NR levels. The explanation for this inter-subject variability in post-dose NR levels is not obvious. The instability of NR in blood samples observed here as well as in prior studies  could be one contributing factor, although it cannot account for all the variability given the steps we have taken in minimizing instability during handling and processing of blood samples. Another possibility is that, based on its hydrophilicity (XLogP3 = –1.8) , NR is expected to exhibit low passive permeability across the human intestinal mucosa. Oral absorption of NR may rely on an active, mediated transport process that varies in active between individuals. It is also possible that NR is degraded to nicotinamide in the gut; nicotinamide is then absorbed and converted to NMN, which can further be converted to NAD+ or dephosphorylated to NR. If true, the degradation of NR to nicotinamide in the gut, which presumably involves purine nucleoside phosphorylase in mammalian and bacterial cells  may be a variable step involved in the oral intake of NR. Hence, investigation into the mechanism(s) of NR absorption and metabolism may afford insights into its variable oral bioavailability.
The highly significant correlation between changes in blood levels of NR and NAD+ supports the expectation that NR serves as a precursor to NAD+. Trammell et al. in their recent study  conducted comprehensive in vivo metabolomic investigations in one male human subject and in C57Bl6/J mouse, from which they were able to identify multiple pathways for conversion of NR to NAD+. One unexpected finding was a remarkable elevation (45-fold) in nicotinic acid adenine dinucleotide (NAAD), which was not thought to be en route for the conversion of NR to NAD+. Further labeling experiments in the mouse showed that at high NAD+ level deamidation of NAD+ to NAAD occurs in competition with NAD+ turnover to nicotamide. Trammell et al. further suggested that NAAD could serve as a metabolite reserve for NAD+ over time and a sensitive biomarker for increased NAD+ metabolism. We did not have an opportunity to measure NAAD in our subjects.
It is worth noting that the blood NAD+ response does not appear to correlate with the absorption pattern of NR; i.e., at steady state, blood NAD+ levels remain relatively constant over the 12-hour NR dosing interval, even though the blood NR concentration peaks around 3 hours and declines thereafter. This apparent dissociation in the temporal profile of blood NR and NAD+ may reflect much slower formation and/or turnover kinetics of NAD+ compared to the clearance kinetics of an exogenous load of NR. Alternately, the observation that 1000 mg NR given on Day 9 did not further increase NAD+ levels in any subject could imply that the maximal effect of NR on raising the NAD+ pool has been attained. Also, the rather short elimination half-life of NR observed in some of our subjects would suggest that frequent dosing throughout a day would be needed to prevent wide fluctuations in body levels of NR. However, given the sustained response of blood NAD+, twice-daily or even once-daily dosing of NR may be sufficient to achieve a desired clinical outcome.
While this study offers novel insights into NR as a nutritional supplement and as a potential therapeutic entity, it does have notable limitations. We enrolled healthy volunteers, who were predominantly white and female. It remains to be determined whether there are gender, age and/or ethnic group-specific differences in NR and NAD+ metabolism; thus the results of this study might not apply generally to diverse patient populations. Similarly, different disease states and pre-existing metabolic derangements also could affect the pharmacokinetics and pharmacodynamics of NR. While the present study indicates the feasibility of elevating the circulating pool of NAD+ by NR treatment; however, NR’s effects on intracellular NAD+ levels and the NADH/NAD+ ratio at critical tissue sites remain unknown. These issues, which are critical in determining the therapeutic potential of oral NR supplementation, must wait for further clinical studies in specific patient populations.
In summary, this study both reports the successful development of protocols for assaying NR and NAD+ levels in whole blood and demonstrates that orally administered NR increases the circulating pool of NAD+ in healthy, human volunteers without apparent clinical side effects or significant changes in relevant laboratory variables. These findings demonstrate the feasibility of translating NR supplementation to a therapeutic reality, as animal studies have shown that NAD+ precursors are beneficial in combatting inflammation, ischemic/hypoxic injury, oxidative stress, and cancer [11, 12, 22, 23]. In particular, NR appears to be well positioned as a novel therapy for systolic heart failure, where impaired mitochondrial oxidative phosphorylation and disturbed NAD+ metabolism are contributory factors for its development and progression [7–9, 12]
- 1. Kolwicz SC Jr., Purohit S, Tian R. Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Circ Res. 2013;113(5):603–16. pmid:23948585
- 2. Marin-Garcia J, Goldenthal MJ. Mitochondrial centrality in heart failure. Heart Fail Rev. 2008;13(2):137–50. pmid:18185992
- 3. Neubauer S. The failing heart—an engine out of fuel. N Engl J Med. 2007;356(11):1140–51. pmid:17360992
- 4. Bayeva M, Gheorghiade M, Ardehali H. Mitochondria as a therapeutic target in heart failure. Journal of the American College of Cardiology. 2013;61(6):599–610. pmid:23219298
- 5. Doenst T, Nguyen TD, Abel ED. Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res. 2013;113(6):709–24. pmid:23989714
- 6. Nickel A, Loffler J, Maack C. Myocardial energetics in heart failure. Basic research in cardiology. 2013;108(4):358. pmid:23740216
- 7. Wang W, Karamanlidis G, Tian R. Novel targets for mitochondrial medicine. Sci Transl Med. 2016;8(326):326rv3. pmid:26888432
- 8. Karamanlidis G, Lee CF, Garcia-Menendez L, Kolwicz SC, Suthammarak W, Gong G, et al. Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure. Cell Metabolism. 2013;18. pmid:23931755
- 9. Lee CF, Garcia-Menendez L, Karamanlidis G, Tian R. Restoration of NADH/NAD ration delays pressure overload-induced cardiac dysfunction via regulation of mitochondrial protein acetylation and permeability transition. Circulation. 2013;128:A15979 (abstr)
- 10. Hsu CP, Oka S, Shao D, Hariharan N, Sadoshima J. Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. Circ Res. 2009;105(5):481–91. pmid:19661458
- 11. Yamamoto T, Byun J, Zhai P, Ikeda Y, Oka S, Sadoshima J. Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. PLoS One. 2014;9(6):e98972. pmid:24905194
- 12. Canto C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metabolism. 2012;15(6):838–47. pmid:22682224
- 13. Team RC. R: A language and environment for statistical computing. R Foundation for Statistical Computing. Internet: https://www.r-project.org/ Vienna, Austria 2015 [https://www.r-project.org/.
- 14. Wickham H. ggplot2: Elegant Graphics for Data Analysis. New York: Springer-Verlag New York; 2009.
- 15. Creeke PI, Dibari F, Cheung E, van den Briel T, Kyroussis E, Seal AJ. Whole blood NAD and NADP concentrations are not depressed in subjects with clinical pellagra. J Nutr. 2007;137(9):2013–7. pmid:17709435
- 16. Trammell SA, Schmidt MS, Weidemann BJ, Redpath P, Jaksch F, Dellinger RW, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016;7:12948. pmid:27721479
- 17. Guyton JR, Bays HE. Safety considerations with niacin therapy. Am J Cardiol. 2007;99(6A):22C–31C. pmid:17368274
- 18. Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(25 Suppl 2):S1–45. pmid:24222016
- 19. Ratajczak J, Joffraud M, Trammell SA, Ras R, Canela N, Boutant M, et al. NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells. Nat Commun. 2016;7:13103. pmid:27725675
- 20. Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metabolism. 2011;14(4):528–36. pmid:21982712
- 21. Wielgus-Kutrowska B, Kulikowska E, Wierzchowski J, Bzowska A, Shugar D. Nicotinamide riboside, an unusual, non-typical, substrate of purified purine-nucleoside phosphorylases. Eur J Biochem. 1997;243(1–2):408–14. pmid:9030766
- 22. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013;155(7):1624–38. pmid:24360282
- 23. Santidrian AF, Matsuno-Yagi A, Ritland M, Seo BB, LeBoeuf SE, Gay LJ, et al. Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. J Clin Invest. 2013;123(3):1068–81. pmid:23426180

domain: biology


text:
BLOOMINGTON – In honor of March being National Nutrition Month, make a plan to hit your health goals by eating better and stopping smoking.
“There are many reasons to eat healthy and quit smoking,” said IU Health Community Health Tobacco Prevention Coordinator Patricia Colon, MPH, CHES®. “Both can help you lower your cholesterol and improve your lifelong health.”
And smoking cessation has the added benefit of making food taste and smell better.
IU Health Bloomington Community Health Registered Dietitian Nutritionist, Stacey Matavuli has five tips on maintaining a healthy diet and managing weight as you quit smoking:
- Focus on Five: Consume five servings of fruits and vegetables daily. A serving is generally ½ cup cooked or canned, 1 cup raw, or a tennis ball sized fruit.
- Choose High Fiber: Focus on increasing whole grain consumption to make half your grains whole. Select foods that list “whole” as the first and primary ingredient on the ingredient list. Examples are whole wheat flour, whole corn, whole beans, etc.
- Eliminate drinking calories: Eliminate or reduce calorie containing beverages including sugar-sweetened drinks such as soda, sweet tea, sports drinks, juices and alcoholic beverages. Our bodies do not regulate these calories the same as calories we chew leading to an excess consumption of energy beyond what the body needs.
- Fuel Your Body: Eat at regular intervals daily to avoid reactive eating and manage hunger cues. Consider eating at least three fuel groups per meal for balance and variety.
- Avoid the Fad: Trendy diet recommendations will assist with weight loss temporarily, but finding a sustainable eating pattern and ways to improve your eating for the long haul will serve up long-term success!
Get free assistance from the Indiana Tobacco Quit Line at 1-800-QUIT-NOW or visit QuitNowIndiana.com for more information.
For more on local tobacco prevention and control efforts, visit Tobacco Free Coalition of Monroe County on Facebook.

domain: food


text:
During his inaugural address, President Joe Biden referenced "unity" multiple times. Americans haven't believed he can for some time now, but recently it's seemed even less believable. Jaime Harrison, though, who chairs the DNC, still thinks the American people can be made to believe Biden's message of supposed unity remains the same.
"Biden said [in his inaugural address] we should not view each other as adversaries in this country but as neighbors...how does 'semi-fascism' as a label for the Republican Party fit with that?"— RNC Research (@RNCResearch) August 28, 2022
DNC CHAIR JAIME HARRISON: Biden "has always been consistent"
Harrison's sticking up for the president's rhetoric during his appearance on CBS News "Face the Nation" came days after Biden said Republican philosophy was "like semi-fascism."
As Townhall has covered, the president on Thursday attended a DNC fundraiser in Rockville, Maryland, a "safely Democratic" D.C. suburb. During his remarks, he went hard against Republicans. "What we're seeing now is the beginning or the death knell of an extreme MAGA philosophy. It's not just Trump, it's the entire philosophy that underpins the — I'm going to say something — it's like semi-fascism," he claimed. White House Press Secretary Karine Jean-Pierre doubled down during media appearances and Friday's press briefing.
On Sunday, "Face the Nation" host Major Garrett reminded Harrison of how Biden chose to frame his inaugural speech. "In that Inaugural Address, President Biden said we should not view each other as adversaries in this country, but his neighbors and we should treat each other with dignity and respect. How does semi fascism as a label for the Republican Party fit with that Inaugural Address," he asked him.
Harrison tried to sing Biden's praises, even doubling down on the president's insults, before Garrett cut him off to get a clear answer.
"Well, the one thing that President Joe Biden has been is always been consistent, and he has always been somebody who does what my grandfather used to do, which is speak it plain, say it plain to the the American people. And what we see right now is a full frontal attack by these extreme MAGA Republicans in this country," Harrison began his response to that question with.
"Mr. Chairman, you embrace the rhetoric, 'semi fascism' to describe the Republican Party," Garrett cut him off to ask, with Harrison taking issue with the phrasing of such a direct question.
Harrison went on to call out Republican views, as well as Florida's Gov. Ron DeSantis and a concurring solo opinion by Justice Clarence Thomas:
Well, it's not about the embracing – its calling what what it is what it is, in the end of the day, we are a country built on freedom. And when you chip away at that, when you see the bullying that takes place in place like Florida with DeSantis, when you see them chip away at privacy rights when they try to demonize the other, that the attacks on transgender kids and their families, the attacks on marriage equality that we're hearing from the Supreme Court.
This is not who America is. We're about freedom and rights for all of America's people, not just a select few. But the Republicans are turning a blind eye - this extreme agenda, and this is what this election is all about. It is the great contrast between a party, the Democratic Party, that is standing up for the hopes and aspirations of the American people and protecting our rights as Americans and our freedoms. And a Republican party that is focused on fear, that's focused on fraud that is focused on just getting power.
The Thursday night fundraiser, was described by the Associated Press as an event that was "meant to ease Biden into what White House aides say will be an aggressive season of championing his policy victories and aiding his party’s candidates." But, it also likely highlights the desperation from Biden and the Democrats as they demonize their opponents a little over two months before the midterms.
While many Democrats and their allies in the mainstream media claim Democrats have a greater shot of holding onto the Senate and potentially even the House, pointing to a poll increase for the president, Biden still remains at just a 41.9 percent approval according to RealClearPolitics.
Further, a Civiqs poll shows Biden is doing poorly, including and especially in battleground states.
NEW: @Civiqs | 08/27— InteractivePolls (@IAPolls2022) August 28, 2022
Biden Job Approval
New Mexico: 38/53
New Hampshire: 39/51https://t.co/aNSbAOfokX pic.twitter.com/TbQZstYPOs
The segment went beyond discussing 2022, as Harrison also assured Garrett that Biden "has consistently said that his intention is to run for president in the United States," offering "the Democratic National Committee will be fully behind behind him and Kamala Harris" as he claimed "this president has a record of achievement, and America needs President Biden to continue that effort."
Whether or not Harrison and the DNC actually believe Biden should and will run for re-election, the American people don't, including fellow Democrats.
Also on Sunday, a USA Today/Ipsos poll revealed that 56 percent of Democrats do not want Biden to run for re-election, and only 60 percent think he can win. In contrast, 59 percent of Republicans think Trump should be their nominee in 2024, while 82 percent of Republicans think he can win. That poll was conducted online from August 18-22, with 2,345 adults and a margin of error of plus or minus 2.5 percentage points.
Such a poll is actually more favorable to Biden than others have been, including a poll from The New York Times/Siena College poll released in early July that found 64 percent of Democrats want someone other than Biden in 2024.


Today is Monday; 30th of the Iranian month of Ordibehesht 1392 solar hijri; corresponding to 9th of the Islamic month of Rajab 1434 lunar hijri; and May 20, 2013, of the Christian Gregorian Calendar. 1487 solar years ago, on this day in 526 AD, as ... IRIB World Service, 2 days ago
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A Jamaat-ud-Dawah (JuD) leader has been found murdered near this eastern Pakistani city, the group said on Saturday. The body of Khalid Bashir, who was associated with JuD's information wing, was found in Sheikhupura, 40 km from Lahore,yesterday. He ...Samaylive, 4 days ago JuD leader found murdered in Pakistan ZeeNews.com, 5 days ago JuD leader found dead DAWN Group, 5 days ago Jamaat-ud-Dawah leader found murdered in Pakistan Indian Express, 4 days ago
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December 13, 2009
Position: 17 38 96 N 61 52 36 W
Date: Dim 13/12/2009 au Lundi14/12/2009
D’Antigua à Barbuda une petite navigation au prêt serré nous a fait le plus grand bien. Nous avons vu une longue bande de sable jaune s’approcher de plus en plus et nous nous sommes mis a l’ancre tout prés. Apres quoi nous avons été émerveillés par une belle plongée sur un des récifs, peu de poissons mais une grande diversité de végétation !!! Et une tortue !! Une première tortue !!! MA première tortue !! Apres nous nous sommes déplacer un peu et avons mis l’ancre a un endroit paradisiaque !!! Au matin nous avons plongé pour rejoindre la plage. Il n’y a pas de mot pour décrire la beauté de cette plage ou les vagues se brisaient une a une en formant un rouleau tout le long de cette plage de sable blanc. Les pélicans, eux, attendaient que de pauvres poissons soient projeté en eau moins profonde et pour plonger a toute vitesse et sans élégance aucune, afin d’attraper leur proies. Mais quel spectacle ! Les rouleaux étaient tel que nous n’aurions jamais pu débarquer sur la plage en zodiac en avons donc nagé. Malheureusement je n’ai prise aucune photo, j’espère que ce moment et ces images resteront graver dans ma mémoire. Car WAWWWW !!!
To go to Barbuda we had to sail close to the wind, and I love that! We dropped the anchor just nearby a wonderful beach where we took the time to snorkel a bit. We didn’t see a lot of fishes but the vegetation was amazing, and by chance we even saw one little turtle. The first one for me! After the snorkeling we went a bit further to spend the night and discovered a paradisiacal island, with nothing else but amazingly big waves and Pelicans. In the morning we went swimming to the beach as the swell was to big for us to come with the zodiac. I can not find the words to describe the beauty of that beach where the waves were breaking all along the white sand. The pelicans were waiting for the fishes to be caught in the shallow water in order to jump without any elegance to catch their prey. It’s an amazing spectacle.
I just hope I’ll remember that beach for a long time as I believe it was the most beautiful one.
December 12, 2009
Position: 17 07 22 N 61 50 78 W
Date: vendredi 11/12/2009 au dimanche13/12/2009
After 20 days at sea, arriving at Antigua was really special, we arrived at sun rise and inside the canal to go to St John’s Harbour everything was quiet… no waves, no wind, the water was peaceful and so were we. We arrived at the only pontoon we saw and it was completely empty. It was magic we stood still at the pontoon and like to put an end to our crossing and to welcome us ashore it started raining… for a few minutes only.
After all the formalities, we entered the city that was full of colors, and joy. People are happy with was they have, the streets and the market are simple, colorful and enjoyable. We decided to take a small bus a go the English harbor, on the other side of the island. The contrast is amazing! The streets were clean and the harbor was full of wonderful big boats where all the crew members were working and cleaning the boats with lots of water. The kind of boat where everybody is cleaning in uniform all the time… the kind of boats we can not afford… but it was nice to dream or imagine ourself crossing the Atlantic with that kind of comfort. Who knows maybe one day. Back to St John’s (and back to reality) the streets were full of people shopping, listening to music, or just being there in the street doing nothing special. It was so crowded we all felt like we needed some peace again and we left to go at anchor, just around the corner. We had our first real swim and went to the beach with palm trees and deckchairs (it felt like holiday) then on the other side of the bay we visited a small wreck. My first wreck ;-). Scaryyyy …
Après 20jours passé en mer l’arrivée a Antigua a été magique. Nous sommes arrive au soleil levant et tout était devenu calme. Faut dire qu’après 19 jours de houle s’est étrange de ne pas sentir le bateau bougé. Une fois a quai et pour la première fois depuis 19 jours nous avons pris notre déjeuner sans s’accroche a nos tasses ! Quel bonheur. Apres les formalités nous sommes allé en ville et avons découvert la simplicité avec laquelle les gens d’ici prennent la vie, les rues sont pleine de couleur et les gens sont heureux. En Début d’après midi nous avons pris un petit bus pour rejoindre l’autre cote de l’ile, English Harbour. La différence entre les deux cotés de l’ile est incroyable, a tel point que l’on ne se croirait pas sur la même ile. Le port était magnifique et accueillait des bateaux gigantesques… le genre de bateau où tout le monde nettoie en uniforme, tout le temps et a grand jet d’eau, le genre de bateau que nous n’aurons jamais… mais ce fut l’occasion de regarder, de rêver et de s’imaginer qu’un jour peut-être nous aussi on traversera l’atlantique avec un tel confort. Qui sait ! De retour a St John’s et de retour a la réalité, les rue s’était remplient de monde a tel point que nous avons tous ressenti le besoin de se retirer dans un endroit plus calme. Nous sommes donc aller dans une petite baie pas loin, à l’abri du regard et avons pu pour la première fois vraiment nous baigner. Nous avons rejoins a la nage une de ces plages de rêve avec cocotiers et transats puis de l’autre cote de la baie nous avons pu visité une petite épave en masque et tubas…ma première épave !!! ca fait drôle !!!
Après 20jours passé en mer l’arrivée a Antigua a été magique. Nous sommes arrive au soleil levant et tout était devenu calme. Faut dire qu’après 19 jours de houle s’est étrange de ne pas sentir le bateau bougé. Une fois a quai et pour la première fois depuis 19 jours nous avons pris notre déjeuner sans s’accroche a nos tasses ! Quel bonheur.
Apres les formalités nous sommes allé en ville et avons découvert la simplicité avec laquelle les gens d’ici prennent la vie, les rues sont pleine de couleur et les gens sont heureux. En Début d’après midi nous avons pris un petit bus pour rejoindre l’autre cote de l’ile, English Harbour. La différence entre les deux cotés de l’ile est incroyable, a tel point que l’on ne se croirait pas sur la même ile. Le port était magnifique et accueillait des bateaux gigantesques… le genre de bateau où tout le monde nettoie en uniforme, tout le temps et a grand jet d’eau, le genre de bateau que nous n’aurons jamais… mais ce fut l’occasion de regarder, de rêver et de s’imaginer qu’un jour peut-être nous aussi on traversera l’atlantique avec un tel confort. Qui sait ! De retour a St John’s et de retour a la réalité, les rue s’était remplient de monde a tel point que nous avons tous ressenti le besoin de se retirer dans un endroit plus calme. Nous sommes donc aller dans une petite baie pas loin, à l’abri du regard et avons pu pour la première fois vraiment nous baigner. Nous avons rejoins a la nage une de ces plages de rêve avec cocotiers et transats puis de l’autre cote de la baie nous avons pu visité une petite épave en masque et tubas…ma première épave !!! ca fait drôle !!!
December 11, 2009
Atlantic Ocean – Antigua - day 20
Position: 17 07 22 N 61 50 78 W
Date: arrivée vendredi 11 des 2009 a 7.15 (heure local) et reparti le jour meme a 1800 pour aller a l’ancre
Date: Arrived Friday 11 dec 2009 at 7.15 am (local time) and left same day at 6pm to go at anchor
On day 17 we had some gusts again the only strong one, pushed us for a few seconds to a speed of 12 knots and we were too late to reduce at night so it broke the ring of the “jib-boom” that is attached to the mast, so that the jib-boom fell and woke up everybody at 2.25 am but more noise than else really. We took the jib down and with the biggest misfortune the halyard went up the mast , we waited the following morning to go up the mast to take it down again in order to put the jib and the genoa as previously on the 2 forestay in butterfly with the “jib-booms”(see pics)
For the rest of the day we had a few more light ones with as only inconvenient the rain.
Fortunately the sunshine came to dry everything soon enough, and at least everything was cleaning before our arrival. For the last few days we had to steer again as the rolling became again too strong for the pilot to hold, steering in the middle of the ocean gives a strange feeling, you start thinking of this immensity of the ocean and us 4 on a small boat in the middle of it, nearly surfing on the waves (when you steer well) Amazing.
Around 8pm on day 19 we saw the light of the land in front of us. Arrival with the rising sun above St John’s harbor in Antigua. That’s it! The dream is done, we made it! and it was an experience we will never forget.
December 06, 2009
Atlantic Ocean 2000 miles – day 15 – 696 miles to go.
Position: 18 59 80N 49 46 85W
Date: Dimanche 6 décembre 2009
Still 1200 miles to go and the wind dropped! Let’s put the Spinnaker and the main sail. We spend 24hours under Spinnaker and auto pilots without any problem. The watch was of course just a bit more stressful as a knot is quickly done in a beautiful light and colorful sail as the Spi. 24hours did I say… oh I meant 22h… just before lunch, just as an occupation we had to undo the magnificent knot around the forestay and once done we decided to put the genoa again as the wind could not even keep the Spinnaker open at some time and it was too risky to keep it. (pics to follow)
On day 13 in the afternoon we started to have a few light gust of wind and rain, it’s easy to recognize, when it’s cloudy and it’s dark under the cloud… and if it is coming towards you à it’s not good. Often we had no wind a moment before and the wind was coming from changing direction…(pics to follow) Luckily we had only a few light rain and wind gust with max force 6 but, During 24 h we had a few gusts lasting not longer than 10 mins every 2 or 3 hours, just the time for everything to dry in between. Once again the watch was not easy as we had to reduce sails in doubt when dark clouds were approaching. At dinner time we saw a few thunder light just beside us, it was beautiful, scary and exciting at the same time, happily we did not have thunder light in the one going pass us.
2 days later we celebrated the 2000 miles sailed since the Canary… with champagne again!
December 02, 2009
Atlantic Ocean “half way celebration”- day 11 – 1211 miles to go.
Position: 20 01 13 N – 40 38 05W
Date: Wed 2nd of December 2009
Half way there and we realize how we have taken a nice little routine the last few days, no one is complaining and everybody is happy and holding on to each and every moment of this adventure. (as well as holding on to our plates and glasses every times we eat because of the heaving of the sea)
We are all here on board with a nice little wind pushing us to the Antilles and the sun is shining while everybody is probably under the rain in London, Brussels or Paris… one more reason to hold on to those moments.
It’s full moon and for a 2 days only we can assist to the rising sun behind us simultaneously with the moon set in front of us. No words are great enough to describe the beauty of nature in those moments.
We had the moon keeping us company for nearly the all trip, and the watch being taken in rotation every night, we all have had the occasion to see the moon go up and down, to have 3 full hours with the moon light or without moon light which make it easier to see the flying starts and to study the sky when not cloudy. Twice we had the moon rise during diner, it’s amazing! Have you ever seen a moon rise? When going west we also had to change hours every time we sailed 15degrees west, we finally have a total of 5 hours difference with France. We also all had a few sun set early in the morning when the 3 others are still asleep. Nature is just amazing, I realized we did not watch the sun go up and down enough in the city (did you?) and how lights and pollution make it difficult to recognize the stars while leaving in a city. At sea everything is clear on the horizon. (when not cloudy – of course ).
So yes, half way! And with champagne again and “foie gras” this time we celebrate all that! But as from now, as we are in the middle of the ocean, far from everything, we are starting to approach the other side, until now we were just getting away from the last piece of land we saw. Do we want to get on the other side? We may as well just stay here and enjoy the daily life on board swinging on the motion of the sea….
Maybe I’ve read too many books … did you btw read books OF Philippe Jeantot or Bernard Moitesier, if not I recommend them (merci Alex).
November 29, 2009
Atlantic Ocean St 1000 miles – day 8 – 1735 miles to go
Position: 19 29 15 N – 32 27 94 W
Date: Sunday 29 November 2009
It is only one day after change of course that we could celebrate the 1000 miles already sailed since the Canary Island! And of course we had “Canard confit” and “Champagne!!”.
But as from day 7we also started to have more change or more maneuvers I would say, We put the main sail and the genoa only as the wind was East. During the night the genoa sheet broke for the first time. For a few days we had to steer at times, as the swell was to strong for the automated pilot. When the wind turned NE we changed the sails to Genoa on PS and jib on SS. Even tough we would check every morning if all was resisting wear, the same sheet broke a few more times on the way, luckily we finished the trip with just enough length not to have to change it. ;-)
16 dec 2009
pics and story until now will be posted once good connection available,
so far all goes well, thanks a lot for your support!
now in St Barth we will go at anchor for a few days before going to St martin.
November 28, 2009
Atlantic Ocean day 7 – 1891 miles to go…
Position: 19 39 70 N 29 59 62W
Date: Saturday 28 novembre, 12’o clock
The first week of the crossing we decided to go down south in order to get the Alize NE.
Depending on the wind ENE or NE we were holding the course 220 – 250 and sailed about 130 – 150 miles per day.
As per the other crossing we maintain our watch of 3 hours each staring from 9pm, till 6 am. On the second day we saw one whale, keeping us company during our morning maneuver, as we decided to put two jibs/Genoa with booms on the 2 forestays. The whale was impressive, swimming behind us then in front of us, on starboard then on portside… she did not breathe a lot out of water but we could see her trough the water. (if the connection is good enough I’ll upload some pics)
It took us a few days to adapt to the rhythm of the boat swinging the all time due the swell. The main occupation where sleeping and eating…. For those who were eating.
On day 3 we saw a sailing boat who was competing with the ARC association, and we made VHF contact. It is really nice to know that we are not alone out there. We came really close to each other so that we could wave goodbye and goodluck!
Soon we took our mark and started to have our little “on board routine” like, watching the sun rise, having breakfast together, reading, sleeping, watching the horizon for hours in the hope to see dolfins, whales, flying fish, or even an other vessel. Then, just before lunch, if we were not changing the sails, we would make the 12’o clock position calculation with sextant or GPS. Just to see hom many miles we achieved in 24h.
We could even have a nap after lunch as long as someone was outside watching out. Around 6 we would watch the sun go down make space for to the stars, flying stars and the moon. On day 7 we changed course to 270-280 as we were south enough, as we can read in books; the flying fish were there to say we cough the Alize NE. Once more we had to adapt at the swell coming from another angle…but yeah we will not complain.
November 21, 2009
Canary – Gomera
Position Gomera: 28 05 33 N - 17 06 46 W
Date: Sat 21/11/09 till Sunday 22/11/09
We left Marina Del Sur on Saturday morning for los Cristianos where we filled the fuel tank, on the way we decided to make a last stop at Gomera Island. Mid way between the 2 islands we saw a few small and shy whales. The harbor of Gomera seemed to be one of those where people get prepared for the long trip. We went to a nice small and local restaurant where we had the chance to eat some tasty local food. That evening we met 4 girls getting ready to row across the ocean racing against male teams. This is THE adventure, really! During the crossing we often though about them wondering how they were handling the big swell e were facing.
We left the island of Gomera at 10.40am to start our journey across the ocean, all ready to go.
Nous avons quitté la Marina Del Sur Samedi matin pour aller a Los Cristinos afin the faire le plein de fuel. Sur le chemin nous avons décidé de faire un dernier arrêt avant le long voyage à l’ile de Gomera. En chemin nous avons eu l’occasion de voir quelques globicéphales assez timide car des que on les apercevait ils replongeaient vers les fond plus profond. Le port the Gomera ressemble encore a un de ces port ou les bateaux se prépare à faire la traversée, l’ambiance y était assez sympa. Nous sommes allé dans un petit restaurant locale très sympa ou nous avons pu goutter les délicatesses locale. Le soir même nous y avons rencontré 4 filles qui se préparaient à faire cette même traversée mais a la rame ! Elle allait affronter des équipes masculines et n’arriverais que deux mois et demi plus tard aux Antilles. Alors CA c’est de l’aventure. Chapeau les filles et courage ! Durant la traversée nous avons souvent pensée à elles en se demandant comment elles faisaient dans cette immense houle qui nous a bordés tout au long du voyage.
Nous avons quitté l’ile de Gomera Dimanche 22 novembre à 10.40 fin prêt pour la traversée.
November 14, 2009
Anchor place around Las Galettas – Anchor place at Los Cristianos.
Position: 28 02 48N 16 42 64 W
Date: Arrivé Samedi 14 vers 17h et reparti ?
Date: Arrived Sat 14th around 5pm and left ?.
We left only to try to find a place where we could go ashore with the zodiac to do some shopping and have dinner. We arrived in Los Cristianos that had an official anchoring place a bit before the harbor. We anchored and rowed until the nearest beach, had dinner and bought some bread before coming back to the boat. We spend the day refreshing the boat, drying everything and cleaning everything. And on my side writing for this blog as well.
If all goes well tomorrow we should go ashore and spend the rest of our time here visiting the island. We will probably rent a car and go to the Teide that has an altitude of 3718 m and other important interest points. When the crew will be complete, we will complete the shopping and the reparation (oh did I mention the leak in the fresh water tank?) and then we will unmoor to go and cross the ocean.
If all goes well we should leave around the 21st of November or maybe one or two days later, as we are not going to Cape Verde the crossing could take around 20 days but it could be more depending on the wind.
See you on the other side!
November 13, 2009
Candelaria, Tenerife to Anchor place around Las Galettas
Position: 28 01 04 N 16 37 47 W
Date: Arrivé vendredi 13 vers 14h et reparti samedi vers 15h.
Date: Arrived Fri 13th around 2pm and left Sat around 3pm.
As we had no wind, we had to motor south until we found a nice place to stay at anchor. We had a full morning; we left Candelaria at 7am had a nice coffee to start the day and breakfast while going around the coast of Tenerife. The swell was important and we had to hold on to our bread, until a wave that I did not expect made me slide and fall with the cockpit table. It was a nice little mess with orange juice, coffee, bread etc… well cleaning the cockpit was part of the program anyway… A bit further we caught a “dorade” again, 60 cm ;-) Knowing there is only the 2 of us for a few days we decided to take the lines out of water for now.
The coast of Tenerife is an alternation of super hotel complexes and wild landscape, that’s near one of those landscapes that we finally found a place protected from the swell where we could anchor. For the first time since I’m here I went for a real swim (I mean real when it’s more then jump into the water and come back because it’s too cold). I had a look around snorkeling a little, but nothing to see but sand. It was just great, lately I had the feeling not to have done anything but sailing sailing sailing and visiting visiting visiting. Even if it is pleasant and interesting, I have to say that after a marathon of sailing and visiting, staying there at anchor, swimming and reading in the sun (as recently the sun wasn’t as great as expected) was marvelous. At the same time we needed to open the windows in order to dry the boat and take everything out of the lock in order to dry the sails and rigging. Because of the big swell we had a few waves coming in ;-).

domain: geography


text:
Why You Need Crop Insurance
If you are a farmer, you know that your crops are your business. They are what keeps this country thriving, which is why it is so important to make sure they are covered under the right plan. With crop insurance, you won’t have to worry when disaster strikes because you know you will be taken care of. It is there to help you financially recover by paying the bank, fertilizer suppliers, equipment providers, and landlords before purchasing your production inputs for next season. Crop insurance is not only necessary for farmers, but critical to keep providing the products America depends on.

domain: economics


text:
10 Feb, New Delhi: Indian farmers joined people with HIV and small traders to protest against the EU-India Free Trade agreement, which will impact all three sectors by ending livelihoods and cutting access to cheap medicines. EU is calling for a speedy resolution of this agreement, while the Indian government has not undertaken any democratic consultations or impact assessments and the text is still kept secret from the people.
Small and medium farmers are against free trade in agriculture which encourage dumping of cheaply produced food products and put local food producers out of business while cutting the ability of nations to feed themselves by increasing reliance on imports. They instead support food sovereignty which is the ability of nations to feed their people through local production by small farmers, local resources, local agro-ecological methods and traditional knowledge of farmers. They oppose the corporate take over of the food system that cares more about profit than people or nature. This FTA is precisely a corporate take over of the food system, where agribusiness in both EU and India will benefit while pushing small farmers and milk producers out of business in both the regions.
Below is the letter from the farmers to the Prime Minister:-
Under this trade agreement, EU is demanding that India must reduce import tariff to zero on 92 percent of tariff lines in agricultural and industrial goods. This will have seriously detrimental effect on India’s rural livelihoods, on agricultural production and consequently on our food security. It has been projected that the India-EU BTIA may lead to increased imports of dairy products, coffee, tea, cereals, fruits and vegetable, meat and poultry products and other value-added agriculture products. EU has an unfair export advantage in all of these products. The cheaper imports of dairy products from the EU's heavily subsidised and protected dairy sector could result in a significant dislocation of local producers of milk and dairy products in India and women farmers will be worse affected as dairy employ a large population of women. It will have serious and long-lasting impact as the bulk of our rural population is dependent on them for employment and livelihood. Indian farmers and farming are already under great distress due to the trade liberalization under the WTO regime and since 1995 when India signed WTO, more than 250,000 farmers have been reported to have committed suicides, making this the largest wave of suicides in the world. The drastic reduction of agricultural tariff under BTIA will flood the Indian market with heavily subsidized and ‘surplus’ agricultural produce from 27 European countries and it will lead to another spate of farmers’ suicide in the country.
Several reports and studies have confirmed that India’s gain in agricultural exports to EU will hardly increase under the BTIA, as compared to EU’s exports which is poised to gain substantially (CEPII-CIREM 2007). Since EU agricultural subsidies are off the trade negotiations under BTIA, they would continue to pose hurdles for Indian agricultural exports to EU. The strict food standards in EU (uneven across 27 EU member countries) pose another great challenge for our exports to EU. That’s why India gains much lower (83 million USD in agro processed food and 33 million USD in primary products) or negligible (USD 7, 2 and 1 million USD respectively in cereals, other crops and products of animal origin) amounts.


text:
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Jose Mourinho says he’s not had enough cash to spend at Old Trafford despite spending close to £300m in his 18 months in charge.
And the Portuguese could be set for further frustration when the transfer window reopens next month as The Times report the Man Utd board do not expect to make any additions in January.
Mourinho signed three players in the summer with Nemanja Matic (£40m), Romelu Lukaku (£75m) and Victor Lindelof (£31m) all joining.
The United boss was also chasing a winger, with Ivan Perisic a leading target.
However he couldn’t get the Inter Milan man so ended up with just three players.
United’s neighbours Manchester City spent almost £200m on goalkeeper Ederson, right-back Kyle Walker, left-back Benjamin Mendy and full-back Danilo.
And Mourinho says he’s not been given enough cash to compete with Pep Guardiola’s side.
“Manchester City buy the full-backs for the price of the strikers, so when you speak about big football clubs, you are speaking about the history of the club," Mourinho said after the Boxing Day draw with Burnley at Old Trafford.
“The sum of £300m is not enough. And the price for the big clubs is different from the other clubs. So the big, historical clubs are normally punished in the market for that history.”


text:
LITTLE DIX BAY
Lodging in the Islands
No Frames Frames
|A classic Caribbean
Virgin Gorda’s Beach Coast,
Dix Bay fills a picture-postcard cove on the Sir Francis Drake Channel
with a beautiful beach behind its own reef and a pastoral valley ashore surrounded by
Earning its five
Rosewood Little Dix Bay offers personalized service for its guests, from the airport greeting to picnic lunches and
its many activities.
The resort has all the dining establishments, activities and facilities in
a self-contained setting, yet is close enough for quick taxi ride or a 15-20 minute walk
to The Valley for those seeking more diverse island life.
the romantic notion of the vacationing guest enjoying the "idle pleasures of the
beachcomber," the original design by Lawrence Rockefeller blended architecture with
the natural beauty of the islands. Gifted stonemasons and other artisans incorporated
stone and woods such as purple heart, mahogany and ash into the structures.
Guests arriving by water through a cut in the reef will not notice any
obtrusive buildings, only white sand with Bohio sunshades. The rooms,
cottages and suites are
scattered along the breath and length of the cove, some grouped from two to eight to a building and
secluded from the beach by a grove of coconut palms and sea grapes.
The Tree House Cottages are most desirable, built in beachside pairs of
nicely-styled, somewhat larger, hexagonal room shapes that feature fieldstone
walls, peaked roofs and exposed wood beams. And with more spacious bathrooms.
Beach Front Cottages, also hexagonal, are on stilts nestled in the sea grapes a few yards from the beach, with expansive
downstairs patio with hammock and upper sun deck.
All rooms have been tastefully redecorated and have
air-conditioning, separate sitting area, desk and a small refrigerator as well as private
balconies or patios.
Also, the suites feature separate
living and sleeping areas, a spacious bathroom with a deep, oversized
bathtub and a separate shower and direct access to the beach from its
The emphasis is on naturalistic
landscaping, in keeping with Laurence Rockefeller’s original concept of an eco-friendly
Strolling the grounds of Little Dix Bay is a favorite activity–and like
touring a succession of small gardens. Mahogany and calabash trees add to the canopy of
palms and seagrapes. The terrain is broken by an occasional group of granite boulders.
Amid the profusion of bougainvillea, flamboyant and the intensely fragrant
frangipani, unusual plants such as silk oak blend with the tropical flora.
Complementary activities include
snorkeling gear and lessons, sunfish sailing with lessons, kayaking, hiking
trails across the full 500 acre area, tennis racquets, ball machine and clinics, bicycling
and water taxis to nearby beaches. Reserve the popular trip to a secluded cove a day or
two ahead and make sure to take enough drinks.
And of course there is Little Dix Bay’s famous
Rose Buds™ for Children
Every conceivable activity can be arranged by the staff at an extra cost,
from diving, jeep rentals and island tours, fishing, water-skiing, glass-bottom boat tours, day sails,
sunset cocktail cruises, and massage therapy.

domain: travel


text: Urban Geometric has never been bored! The design is a reflection of dynamism and simplicity. Strategically surrounded by Sunter business district area and shopping malls. Facilitated with sTREATs Restaurant, meeting rooms, gym, reflexology path and Kids Corner as a perfect place for business and leisure travelers to indulge at an affordable rate. Completed with a high speed WiFi Internet access and free shuttle to JIExpo Kemayoran, Kelapa Gading Mall, Mal of Indonesia and ITC Cempaka Mas.


text:
Our Powercode v19.14.12 release makes our newest Google Maps release available to every existing Powercode customer! 19.14.12 includes our latest stable build for Google Maps, including mapping updates and performance enhancements for Schedule Live View, Complete Map, Elevation Profile, and much more! Detailed instructions on how to enable and set up Google Maps to work with Powercode can be found our our Knowledge Base. If there are any questions regarding the new release or Google Maps, please reach out and our Customer Experience Team will be happy to help!
- New Full Google Maps Integration
- IPPay Automatic ECheck Reconciliation and Account Updater Support
- CnMaestro v2 API Support
- Added Slowed Services to Preseem
- Established the ability to limit Equipment Status Change log items
Along with Google Maps, 19.14.12 also includes the following releases. Check them out to see everything we’ve been working on!