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Upregulation of microRNA-125b by G-CSF promotes metastasis in colorectal cancer
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Xinghua Zhang1,*, Xiao Ma1,*, Huaying An1, Changqing Xu2, Wenjo Cao3, Wei Yuan1,4 and Jie Ma1,4,5
1State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
2Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China
3Department of Science, University of British Columbia, Vancouver, Canada
4Clinical Immunology Center, Chinese Academy of Medical Science, Beijing, China
5Department of Biotherapy, Beijing Hospital, National Center of Gerontology, Beijing, China
*These authors are contributed equally to this work
Wei Yuan, email: [email protected]
Jie Ma, email: [email protected]
Keywords: colorectal cancer, microRNA-125b, MCL1, G-CSF, metastasis
Received: November 25, 2016 Accepted: March 27, 2017 Published: April 06, 2017
Although there are reports of miR-125b being dysregulated in colorectal cancer (CRC) and associated with CRC progression, little is known about its intrinsic regulatory mechanisms. Here we detected the expression of miR-125b in CRC tissues, subsequently investigated the effect of miR-125b on the proliferation, apoptosis, cell cycle and metastasis on CRC cells. Our results showed that the expression of miR-125b was significantly decreased in CRC tissues comparing to adjacent tissues. However, with the stimulation of Granulocyte colony-stimulating factor (G-CSF), which was highly expressed in CRC tissues, the expression of miR-125b could be improved. Analysis of patient samples revealed that miR-125b presented a clear association with poor differentiation, positive lymph node metastasis, and advanced TNM stage. Overexpression of miR-125b inhibited cell proliferation, triggered G2/M cell cycle arrest, induced subsequent apoptosis, and promoted cell migration and invasion. Moreover, luciferase reporter assays and western blot clarified that the myeloid cell leukemia 1 (MCL1) was a direct target of miR-125b. Thus overexpression of MCL1 attenuated the pro-metastasis function of miR-125b in CRC cell lines. In addition, the protein expression level of MCL1 was decreased in CRC tissues from patients with positive lymph node metastasis, which had high miR-125b expression. Collectively, our study suggested that miR-125b induced by G-CSF plays a promoting role in the metastasis of CRC by targeting MCL1, which may serve as a novel therapeutic target for CRC metastasis.
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domain: biology


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domain: entertainment


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As part of the retirement income planning puzzle, there are several unique risks or challenges that you must account for in your planning for retirement that are different from the risks when simply saving for retirement.
Unknown Time Frame – Longevity Risk:
- No one knows how long they will need their income to last, but they are certain they don’t want it to run out. In general people are living longer today, so most will have to plan for their income to last a greater time period than previous generations.
- For couples aged 65 today, the FP Canada guidelines suggest that CERTIFIED FINANCIAL PLANNER® or CFP® professionals plan to age 98 for them (25% chance one of them will be alive then).
- Inflation risk is the risk of not being able to maintain your purchasing power during retirement. Over time everything can become more expensive and can have spikes like in 2022.
- To maintain your purchasing power you need to be able to increase your income in retirement, much like an annual pay raise while you were working.
- Taxation Risk is the risk of your tax rates increasing over time and paying more in taxes than you otherwise might have if you had organized your investments in the most tax-effective manner.
- One of the best ways to increase your income (and to make your money last longer) is to reduce the amount of taxes you have to pay by structuring your income sources tax effectively.
- This is needed because retirees can have numerous sources of income that need to be coordinated to reduce current and potential future taxation.
- Market crashes (known as “bear markets”) occur on average about every 6 years, so with a 30-year retirement time frame a retiree could live through 5 such “bear markets” or market crashes.
- Retirees must develop an asset allocation (investments) that provides them with the ability to meet their income requirements over their lifetime and fits their risk profile with the ability to navigate the inevitable market turmoil.
Sequence of Return Risk
- The years just prior to retirement and after retirement are the key times for planning to create retirement income. If you have poor market performance just prior to and in early retirement, it can dramatically reduce long-term income.
- Your income strategy should take into consideration that you will not receive consistent investment returns each year.
- Health care can be a significant cost for retirees, and yet many retirees have not factored in extra health care costs as part of an aging-in-place strategy or even considered long-term care costs in their plans.
For more information, you can refer to Preserving Wealth: The Next Generation – The definitive guide to protecting, investing, and transferring wealth by Jack Lumsden, MBA, CFP®
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This material is provided for general information and is subject to change without notice. Every effort has been made to compile this material from reliable sources however no warranty can be made as to its accuracy or completeness. Before acting on any of the above, please make sure to see me for individual financial advice based on your personal circumstances. The information provided is for illustrative purposes only. Commissions, trailing commissions, management fees and expenses, may all be associated with mutual fund investments. Mutual funds are not guaranteed, their values change frequently, and past performance may not be repeated. Please read the Fund Facts and consult your Assante Advisor before investing.
Insurance products are services provided through Assante Estate and Insurance Services Inc.

domain: finance


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View Full Version : Uplift Universe - Image Entry: Matthew Moss
04 April 2008, 11:07 AM
Matthew Moss is entered in the "Uplift Universe Challenge" update: View Challenge Page (http://features.cgsociety.org/challenge/uplift_universe/view_entries.php?challenger=15122)
Latest Update: Final Image: Alien Struggle Final Image
04 April 2008, 11:09 AM
my previs is coming, just sorting some stuff out.
04 April 2008, 10:16 PM
oops, double post
04 April 2008, 12:37 PM
When two creatures from alien environments meet for the first time, the only way they both know how to interact is with violence.
04 April 2008, 11:16 PM
This is the base model for my man. In an attempt to learn as much as I can each step of the way, I built this model from scratch. I know time is ticking down, but since beginning this competition I've upgraded my computer and had some fun with that. Hopefully the next few weeks will be very productive.
04 April 2008, 02:35 PM
This is the knife for the guy. I've changed his weapon from a pistol to a knife to make it more animalistic.
04 April 2008, 03:22 PM
hey matt, your male base besh is looking preety good! i really like the hard edges on the muscles that make it look like fantasy anatomy or comic book anatomy, please dont loose that if you are going to sculpt it in something like zbrush, your knife looks preety solid to :thumbsup:
and don't despair about the deadline, just be constant and you'll make it
04 April 2008, 11:21 PM
Test render for my knife.
05 May 2008, 02:45 PM
This is my guy with his finished displacement map. Modeled in Modo, sculpted in Zbrush, touched up in Modo. I'm now on the texturing of him. Today is a public holiday in england so Im hoping to get the rest of the guy finished today so that I can concentrate on the rest of the image in the remaining week.
05 May 2008, 09:19 PM
Title says it all, now I just need to get the alien made, and if time permits, the environment. I hadn't planned on an environment for this piece but seeing some of the entries I realise I need one. Good work everyone.
05 May 2008, 09:39 PM
Nice looking fellow there, the bridge of his nose looks a little pinched, but still cool. He really looks like a fighter, someone who wont give up. Question, where did the scratches and cuts come from? The alien looks like a giant snake, does it have arms hidden out of view? I really like how you have that concept, it really show man fighting the beast to death, on the ropes with only what he has in hand available. :) Can't wait to see more!
05 May 2008, 02:36 AM
Here's my final piece.
The scant story for this image rests around the question of how humanity will respond to a first encounter with aliens. In a reflection on how we treat this world, humanity will most likely go in aggressively, as I imagine the alien race would too. At heart, we're all savages and, ultimately, thats how we will confront each other.
Its been fun.
05 May 2008, 02:36 AM
This thread has been automatically closed as it remained inactive for 12 months. If you wish to continue the discussion, please create a new thread in the appropriate forum.

domain: hobby


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Partner of Casaforte Investimentos, Kristopher is the managing director of Casaforte Energia, where is responsible for the project origination and structuring, energy sale, and fund raising with foreign investors.
In the last 20 years Kristopher accumulated experience in corporate finance and private equity, focusing on acquisitions and financing of the energy sector companies in Brazil and in the US. He participated directly in numerous M&A and equity raising deals valued at more than US$15 billion, working with Morgan Stanley, Wasserstein Perella & Co and Kleinwort Benson. Among his clients were Endesa, Duke, Enel, Excelon, Cerberus, Sempra, and Iberdrola. Also advised the BNDES and Brazilian Ministry of Mines and Energy in conjunction with power sector privatizations, including the sale of the generation assets of Eletrosul. He was also founding partner of Franklin Park Energy, a private equity fund now known as The Guggenheim Infrastructure Fund.
Kristopher has an honors degree in Economics from Vassar College in New York.


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Interactive Circus skills workshop
Against a 75ft wide medieval castle and podiums, featuring all new medieval banners and costumes with flaming torches, pyrotechnics and mystic smoke.With their own self-contained sound system, presenting dramatic music,fanfares and sound effects, they re-create two totally fantastic 40 minute epic plays of “A Tale of Richard the Lionhearted” and “The Legend of King Arthur“.
Britain’s longest established and leading dog display team leave nothing to chance when it comes to giving the audience an outstanding display with a truly unique and fascinating commentary.
The team has huge appeal for old and young alike. They are not a copy of any other dog team and the many different exercises they carry out show they are not just a dog agility team either.
All the dogs in the display team are trained at the Essex Dog Training Centre, Brentwood which two years ago was voted by the public 'The Best Dog Training Facility in the UK’
Come to see these magnificent birds and watch them soar
That's the way to do it. An oldie but a goodie. Come along to see the show
Creepy crawlies and slithering snakes. Have a look if you dare
Dennis the Fire Engine - Dennis is a 1987 Fire Engine (that's where the '87' comes from if you are wondering!).
Come see some classic cars and tractors. If you own one please get in touch if you want your pride and joy to join the line-up.
Meet these beautiful creatures
Plenty for our younger attendees to do under cover come rain or shine
Little ones of all ages will love getting involved in our FREE forest school.
Bring your little one to get involved in mud painting or headdress/bracelet making. They can also make clay creatures, stick men, Elder necklaces, and for the slightly older ones, get the chance to make a bow and arrow, Hapa Zome flag or boat.
Yet more for the little ones

domain: artistic


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Educating India's daughters to be free and equal | Dr. Urvashi Sahni | TEDxChandigarh
Millions of girls in India lead unequal lives. Is there a way women empowerment can be done in India? Is it possible? Dr. Urvashi tells you what she did and how you can do it. Dr Urvashi Sahni is the World Economic Forum’s India Social Entrepreneur of the Year, 2017. She is a women rights activist and educationist working for over three decades. Dr. Sahni is an Ashoka Fellow, a non-resident fellow at the Center for Universal Education at The Brookings Institution, USA and is currently a member of Chief Minister’s Advisory Council, Rajasthan.
Dr. Urvashi also founded Suraksha, a women rights organisation; DiDi’s – a social enterprise for sustainable livelihoods for women and the Study Hall Educational Foundation (SHEF). Through its schools and outreach initiatives, SHEF has trained 24,000 teachers and impacted more than 5 lakh children, most of whom are girls from disadvantaged communities. SHEF directly provides education to over 4000 students.
Dr. Urvashi is a leading expert in school governance, curriculum reform and teacher training with a special focus on girls’ education. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx

domain: sociology


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Calling all masterminds and wordsmiths: let’s “steal” the spotlight with an epic heist scene that even the literary police can’t resist.
Here is how to write a heist scene:
Write a heist scene by establishing high stakes, creating a diverse team, and detailing planning and execution phases. Incorporate tension, unexpected twists, and a vivid setting to enhance the narrative. Avoid skipping specifics or dumbing down security.
In this guide, you’ll learn everything you need to know about how to write a heist scene.
What Is a Heist Scene?
A heist scene is a pivotal moment often found in crime and thriller genres, where characters engage in the planning and execution of a high-stakes theft.
It’s a blend of strategy, suspense, and action, holding the reader’s attention through intricate plot details and character interactions.
This scene typically involves a group of characters, each with unique skills, working together to steal something valuable.
The allure of a heist scene lies in its complexity and the thrill of whether the characters will succeed or face unexpected consequences.
It’s not just about the theft itself, but the planning, the team dynamics, and the obstacles they face.
A well-crafted heist scene can be a showcase of clever writing, character development, and plot progression, making it a favorite among readers who enjoy tension-filled, strategic narratives.
7 Types of Heist Scenes
There is more than one type of heist scene and story.
Classic Bank Robbery
The quintessential heist scene, involving a well-planned robbery of a bank. This type often includes detailed planning, a diverse team with specific roles, and high tension during execution.
Focused on stealing priceless art, this type involves more elegance and sophistication.
It usually features characters with a deep appreciation or expertise in art, and often includes forging or swapping artworks.
High stakes and glamour define this type. The scene is set in a luxurious casino, involving clever schemes to outsmart high-level security and often includes elements of bluffing and gambling.
This type revolves around stealing precious gems or jewelry, often from heavily guarded locations or high-profile events.
It requires meticulous planning and often involves a mix of stealth and social engineering.
A modern twist, focusing on stealing digital assets or information.
It involves hacking, technological skills, and often a race against time to breach sophisticated digital security systems.
While not a traditional heist, it involves similar elements of planning and teamwork to escape from a high-security prison.
It’s more about the escape plan and execution rather than stealing.
Heist with a Twist
This type subverts the usual heist tropes, perhaps involving an unexpected betrayal, a twist in the objective, or a moral dilemma that changes the course of the heist.
How to Write a Heist Scene (40 Ways)
Writing a heist scene is a thrilling challenge that requires a blend of creativity, strategy, and an understanding of human psychology.
A great heist scene isn’t just about the crime itself.
It’s about the characters, the tension, and the stakes involved.
Here are 40 detailed ways to craft an unforgettable heist scene, each accompanied by examples to illustrate the concept.
1. Establish the Stakes
High stakes are the heart of a heist scene.
Make it clear what your characters stand to gain or lose. This could be monetary, personal, or even moral.
For example, in Ocean’s Eleven, Danny Ocean’s team isn’t just after money.
There’s also the thrill of the challenge and personal scores to settle. Establishing stakes that resonate with your characters deepens the emotional impact of the heist.
2. Create a Diverse Team
Each member of your heist team should bring a unique skill set and personality.
Think of The Italian Job, where each character has a specialty, whether it’s driving, explosives, or hacking.
This diversity allows for interesting interactions and solutions to problems that arise during the heist.
3. Intricate Planning
Detailing the planning phase adds credibility to your heist.
It’s not just about the action; it’s about how well your characters can anticipate and solve problems.
In Inception, the planning phase is crucial as the team must understand and navigate the complexities of the human mind.
This phase should be logical yet creative, showing the reader how the heist could realistically be pulled off.
4. Build Tension
Tension is what keeps readers turning the pages.
Introduce elements that threaten the heist’s success, whether internal conflicts, external obstacles, or moral dilemmas.
In Heat, the tension escalates as the crew realizes they’re being watched by the police, adding a layer of urgency and risk to their actions.
5. Use Time Constraints
Adding a ticking clock can dramatically increase the suspense.
Whether it’s a security system reset or a guard’s patrol schedule, time constraints push your characters to their limits.
In Mission: Impossible, the team often works against a tight deadline, making every second count.
6. Incorporate Unexpected Twists
No heist goes exactly as planned.
Introduce unexpected twists that force your characters to adapt. This could be a betrayal, an unforeseen obstacle, or a change in the target.
In The Thomas Crown Affair, the twist comes in the form of a complex game of cat and mouse, keeping the audience guessing.
7. Pay Attention to Setting
The setting of your heist should be as detailed as your characters.
Whether it’s a high-tech vault, a bustling casino, or a remote mansion, the setting can add challenges and opportunities for your team.
In The Bank Job, the setting of a bank vault surrounded by businesses and apartments adds complexity to the heist.
8. Use Technology Wisely
In modern heists, technology plays a significant role.
However, it should be used realistically and not as a deus ex machina.
In films like Sneakers, technology is crucial but it’s the characters’ understanding and manipulation of it that makes the plot compelling.
9. Focus on Character Development
A heist scene is an excellent opportunity for character development.
Show how the pressure and moral dilemmas of the heist impact your characters, leading to growth or revealing hidden facets of their personalities.
In Reservoir Dogs, the characters are profoundly affected by the events of the heist, leading to a dramatic and revealing climax.
10. Add Elements of Humor
Humor can be a great way to balance the tension.
It can humanize your characters, making them more relatable and likable.
The humor in Ocean’s Eleven adds charm to the characters, making the audience root for them despite their criminal activities.
11. Include High-Action Sequences
Action sequences are vital in keeping the pace brisk and the excitement high.
These could be chase scenes, fights, or narrow escapes.
In The Fast and the Furious series, high-speed chases and daring stunts keep the adrenaline pumping.
12. Make the Heist Believable
While you can push the boundaries, keeping the heist within the realms of possibility adds to its impact.
Research real heist strategies, tools, and techniques to add authenticity.
The heist in Inside Man is clever and well-thought-out, making it believable and engrossing.
13. Explore the Moral Gray Area
Heists often operate in a moral gray area. Explore the ethics of your characters’ actions and the justifications they make.
This adds depth to your story and challenges the reader’s own moral compass.
In The Town, the characters are deeply conflicted, blurring the lines between right and more.
14. Showcase Team Dynamics
The interactions within the heist team can be as compelling as the heist itself.
Show how they work together, resolve conflicts, and rely on each other’s strengths.
In Leverage, the team’s dynamics are central to the plot, with each member’s personality and skills contributing to the group’s success.
15. Include Realistic Consequences
Every action in a heist should have consequences.
Whether it’s the risk of getting caught or the moral implications of their actions, these consequences add weight to the story.
In A Fish Called Wanda, the consequences are both comical and serious, affecting each character differently.
16. Use Misdirection
Misdirection is a key element in heists.
Have your characters use deception to throw off their adversaries, or use narrative misdirection to surprise your readers.
The twist in The Sting is a classic example of misdirection done right.
17. Detail the Escape Plan
The escape is as critical as the heist itself.
Detail how your characters plan to evade capture after the heist.
This can include backup plans, disguises, or strategic routes. In Baby Driver, the escape sequences are meticulously planned and thrillingly executed.
18. Introduce a Worthy Adversary
A strong opponent, such as a detective or rival gang, can add another layer of tension.
This adversary should be as competent and determined as the heist team.
In Catch Me If You Can, the cat-and-mouse game between the protagonist and the FBI agent adds depth to the story.
19. Utilize Flashbacks and Foreshadowing
Flashbacks can provide backstory and motive for the heist, while foreshadowing hints at possible outcomes.
This narrative technique enriches the story and keeps the reader engaged.
In Ocean’s Thirteen, flashbacks and foreshadowing are used to reveal motivations and hint at future events.
20. Balance Risk and Reward
The risk involved in the heist should be proportional to the reward.
This balance keeps the story realistic and the stakes high.
In The Great Train Robbery, the immense risk is matched by the potentially huge reward.
21. Craft a Satisfying Conclusion
The conclusion of your heist scene should be satisfying, whether it’s a successful heist, a twist ending, or a moral victory.
It should tie up loose ends and reflect the journey of your characters.
In The Italian Job, the conclusion is clever and leaves the audience with a memorable last scene.
22. Use Pacing to Your Advantage
Effective pacing is crucial in a heist scene. Alternate between fast-paced action and slower, tension-building moments.
This ebb and flow keeps the reader engaged and heightens the impact of the climax.
For instance, in Now You See Me, the pacing varies between the intricate magic performances and the frantic chase scenes, creating a rhythm that keeps the audience on edge.
23. Implement Clever Dialogue
Sharp, clever dialogue can enhance character interactions and add an element of wit to the heist.
It can also be used to convey crucial information in a way that’s engaging and natural.
In The Thomas Crown Affair, the dialogue is not only smooth and engaging but also serves to reveal character dynamics and plot details.
24. Highlight Character Motivations
Understanding why each character is involved in the heist adds depth to the story.
Their motivations could range from financial desperation to a desire for revenge or a need for thrills.
In Heat, each character has a distinct motivation, enriching the narrative and adding complexity to their actions.
25. Use Environment to Create Obstacles
The environment can be a source of obstacles or advantages for the heist team.
This could be anything from a high-tech security system to a crowded public space.
In Entrapment, the laser-filled room presents a physical obstacle, adding tension and visual interest to the heist.
26. Incorporate Character Backstories
Backstories can provide context for a character’s skills or motivations.
A well-placed backstory can add layers to the narrative and make the characters more relatable.
In Logan Lucky, the characters’ backgrounds in mining and construction play a key role in the heist’s execution.
27. Utilize Multiple Points of View
Showing the heist from different perspectives can provide a fuller picture and add complexity to the narrative.
This can include the viewpoints of the heist team, law enforcement, and even innocent bystanders.
In Rashomon, the use of multiple perspectives adds depth and ambiguity to the story.
28. Integrate Subplots
Subplots can enrich the main heist narrative.
These could be romantic entanglements, personal vendettas, or side hustles.
In The Usual Suspects, the subplots intertwine with the main story, adding layers and enriching the overall narrative.
29. Show Preparation and Training
Showing the team training or preparing for the heist can build anticipation and demonstrate their commitment and skills.
In The Score, the preparation phase is crucial, showcasing the expertise and meticulous nature of the characters.
30. Add Ethical Dilemmas
Ethical dilemmas can add moral complexity to the heist, forcing characters to make tough choices.
This can create internal conflict and add an emotional layer to the narrative.
In Dog Day Afternoon, the ethical dilemmas faced by the characters add a poignant, human element to the story.
31. Introduce Internal Conflict
Conflict within the heist team can add tension and unpredictability.
This could be due to clashing personalities, differing goals, or mistrust. In The Town, internal conflicts among the crew members add a layer of drama and uncertainty to the heist.
32. Employ Symbolism and Themes
Using symbolism and recurring themes can add depth and meaning to your heist scene.
This could be a recurring motif or a thematic element that reflects the larger narrative.
In The Da Vinci Code, symbols and themes are central to the plot, adding layers of mystery and intrigue.
33. Leverage Character Flaws
Character flaws can affect the heist’s outcome and add realism to the story.
A character’s impulsiveness, greed, or overconfidence can create complications. In Jackie Brown, the characters’ flaws lead to unexpected twists and turns in the heist.
34. Incorporate Real-World References
Referencing real-world events, technology, or locations can add authenticity to your heist scene.
This grounding in reality can make the story more relatable and believable.
In Ronin, the use of actual locations and references to historical events adds realism to the narrative.
35. Explore the Aftermath of the Heist
Don’t forget to explore the aftermath of the heist.
This can include the distribution of the spoils, the impact on the characters’ lives, or the consequences of their actions.
In No Country for Old Men, the aftermath is as significant as the heist itself, impacting each character profoundly.
36. Utilize Visual Descriptions
Vivid visual descriptions can bring your heist scene to life, immersing the reader in the action.
Describe the setting, the characters’ actions, and the atmosphere in detail. In The Night Manager, the vivid descriptions enhance the tension and realism of the heist scenes.
37. Incorporate Red Herrings
Red herrings can mislead the reader and add an element of surprise to your heist.
These false clues or misleading information can make the outcome more unpredictable. In Sherlock Holmes stories, red herrings are often used to keep the reader guessing.
38. Use Foils and Rivalries
Character foils and rivalries can add tension and drama.
This could be rival heist teams, law enforcement, or personal enemies. In Public Enemies, the rivalry between the bank robber and the FBI agent adds depth to the narrative.
39. Explore the Psychological Impact
Delve into the psychological impact of the heist on your characters.
This could include stress, guilt, or adrenaline rushes, affecting their decisions and relationships. In Thief, the protagonist’s psychological journey is as central as the physical heist.
40. Ensure Logical Consistency
Maintain logical consistency throughout your heist scene.
This includes the characters’ actions, the technology used, and the sequence of events.
In The Prestige, the intricate plot is carefully constructed to maintain logical consistency, making the final reveal both surprising and satisfying.
Here is a video about how to write a heist scene, story, or movie screenplay:
Heist Scene Template
A heist scene template provides a structured approach to crafting an engaging and dynamic scene.
This template offers a general outline that writers can customize according to their story’s needs.
- Introduction: Set the scene and introduce the target of the heist.
- Character Introduction: Introduce the characters involved, highlighting their skills and roles.
- Stakes and Motivation: Clarify what’s at stake and why the characters are undertaking the heist.
- Planning Phase: Detail the heist plan, including roles, strategies, and contingencies.
- Preparation: Show the characters preparing for the heist, gathering tools and resources.
- Execution: The heist in action, showcasing challenges and character dynamics.
- Climax: The peak of the heist, where tension and stakes are at their highest.
- Aftermath: Consequences of the heist, success or failure, and its impact on the characters.
- Resolution: Wrap up loose ends and conclude the character arcs.
50 Heist Scene Ideas
- A team stealing a rare diamond from a moving train.
- A solo hacker attempting to breach a top-secret government database.
- An art heist during a high-profile auction.
- A group infiltrating a corporate gala to steal trade secrets.
- A team of thieves targeting a casino’s vault during a boxing match.
- A heist to recover a stolen painting hidden in a private mansion.
- A daring bank robbery executed within a 10-minute window.
- A digital heist to erase a criminal record.
- A mission to steal a prototype car from a high-security facility.
- An underwater heist to retrieve a sunken treasure.
- An escape artist breaking into a vault for a challenge.
- A group stealing rare books from an ancient library.
- A heist to steal a famous musician’s priceless guitar.
- A mission to retrieve a lost heirloom from a gangster’s safe.
- A team of ex-soldiers robbing a drug cartel’s cash house.
- A heist to intercept a shipment of smuggled artifacts.
- A mission to plant evidence in a corporate office.
- A heist at a ski resort to steal diamonds from a guest.
- A group hacking into a lottery system to rig the draw.
- A heist to steal a valuable manuscript from a book fair.
- A plot to rob a high-speed hyperloop train.
- A heist during a city-wide blackout.
- A mission to steal a famous chef’s secret recipe.
- A heist in a futuristic society to steal memory files.
- A heist to retrieve a scientist’s stolen research.
- A heist at a fashion show to steal a designer’s collection.
- A team stealing a rare coin from a numismatic convention.
- A heist to hijack a cargo ship carrying electronics.
- A mission to steal an ancient relic from a museum exhibit.
- A heist during a space station’s maintenance shutdown.
- A plot to steal a prototype drone from a military base.
- A heist in a dystopian city to procure rare medicine.
- A mission to swap a fake painting in a gallery.
- A heist at an airport to intercept a courier.
- A plot to steal exotic animals from a private zoo.
- A heist to liberate documents from a corrupt politician’s office.
- A mission to steal a vintage car from an auto show.
- A heist in a ghost town to find hidden gold.
- A plot to rob a luxury yacht at sea.
- A heist to steal the crown jewels during a national celebration.
- A mission to retrieve data from a sunken submarine.
- A heist at a tech convention to steal a new AI.
- A plot to pilfer rare plants from a botanical garden.
- A heist to steal a historic sword from a military parade.
- A mission to snatch a rare bird from an aviary.
- A heist during a major sports event to steal memorabilia.
- A plot to rob collectors at a rare coin expo.
- A heist to steal a priceless violin during a concert.
- A mission to obtain ancient scrolls from a hidden temple.
- A heist to capture a holographic art piece from a gallery.
Biggest Mistakes Writers Make When Writing Heist Scenes
Writing heist scenes can be challenging, and there are common pitfalls that writers should avoid:
- Overcomplicating the Plot: Making the heist too complex can confuse readers.
- Underdeveloped Characters: Failing to give depth to the characters involved in the heist.
- Ignoring Realism: Unrealistic scenarios can break the suspension of disbelief.
- Lack of Research: Not researching enough about how real heists, technology, or security systems work, leading to implausible scenes.
- Forgetting the Stakes: Not clearly establishing or maintaining the stakes, which are crucial for tension.
- Poor Pacing: Failing to balance action with character moments or exposition, resulting in either a rushed or dragging narrative.
- Neglecting Character Dynamics: Overlooking the importance of interactions among the heist team, which can add depth and conflict.
- Inconsistent Tone: Shifting the tone abruptly from serious to comedic or vice versa, which can be jarring for readers.
- Using Clichés: Relying on overused tropes and plot devices without adding original elements.
- Failing to Surprise: Not including enough twists or unexpected developments, making the heist predictable.
How to Write a Heist Story
Writing a heist story involves more than just crafting a compelling heist scene.
It’s about creating a narrative that weaves together suspense, strategy, and character development. Here’s how to do it:
- Develop a Unique Concept: Start with an original idea or a fresh twist on a classic heist theme.
- Create Memorable Characters: Develop a diverse cast with distinct personalities, skills, and motivations.
- Establish Clear Stakes: Make it clear what is at risk and what the characters stand to gain or lose.
- Plan the Heist: Detail the heist plan, including obstacles and contingencies, to add credibility and suspense.
- Build Tension and Conflict: Incorporate elements that challenge the characters and their plan, both internally and externally.
- Include Surprising Twists: Keep readers on their toes with unexpected developments and reversals.
- Focus on Pacing: Balance fast-paced action with moments of character development and suspense-building.
- Convey a Strong Setting: Use the setting to add atmosphere, obstacles, and character to the story.
- Explore Themes and Morality: Delve into the ethical and moral implications of the heist and its impact on the characters.
- Craft a Satisfying Ending: Conclude with an ending that ties up the narrative threads and reflects the journey of the characters.
Example of a Heist Scene
Here is an example of a heist scene that I wrote for this article:
In the shadow of the Eiffel Tower, under the cloak of twilight, a semi-professional group of thieves, each a master of their craft, prepared for the heist of a lifetime. Their target: a groundbreaking AI device, nestled securely in the briefcase of a renowned AI engineer, surrounded by a cadre of vigilant bodyguards.
The leader, Jean, a tactician with a penchant for high-stakes jobs, surveyed the bustling Champ de Mars through binoculars.
His second-in-command, Léa, adept in martial arts and stealth, blended into the crowd, her eyes fixed on the engineer. Marc, the tech wizard, sat in a van parked nearby, fingers dancing over keyboards, tapping into security feeds.
As dusk turned to night, the engineer, oblivious to the lurking danger, enjoyed the Parisian evening, his guards relaxed but watchful. Jean, communicating through earpieces, whispered, “On my mark…” and the dance began.
Léa, posing as a tourist, approached the engineer, her charm disarming one of the guards. As they chatted, she subtly signaled Marc. Suddenly, the lights around the Eiffel Tower flickered. Confusion spread among the tourists and guards alike. Marc had hacked the local grid, creating a diversion.
In the chaos, Jean, disguised as a street performer, moved closer, his eyes locked on the briefcase. But as he edged near, a guard, more alert than the others, noticed his keen interest. The guard’s hand moved to his earpiece, calling for backup. Jean’s heart raced. He retreated, blending into the crowd, and the moment seemed lost.
Marc, realizing the plan was unraveling, initiated Plan B. A loud, orchestrated sound of sirens approached, simulating a police convoy. The guards, now on high alert, formed a protective circle around the engineer. It was now or never.
Léa, seizing the moment, “tripped” near the engineer, scattering her belongings.
As the guards helped her, Jean saw his chance. He slid through the crowd, his hand deftly slipping the briefcase from the engineer’s side. But just as he secured it, the engineer noticed its absence. Shouting ensued, guards scrambled, and the tranquil night erupted into chaos.
Jean, briefcase in hand, darted through the crowd, weaving between confused tourists. Behind him, Léa engaged in a swift, distracting fight with two guards, using her martial arts prowess to keep them at bay. Marc, watching through the cameras, guided Jean through the safest path, away from the converging guards.
But their escape was far from assured. More guards poured in, and the exit routes dwindled. Jean, sprinting with the precious cargo, realized the direness of their situation. They needed a miracle.
And then, in an almost serendipitous moment, a group of street performers began a firework display. The sky above the Eiffel Tower lit up, drawing the attention of the crowd and the guards. Jean, using the cover of the fireworks, slipped into a side alley, his heart pounding in his chest.
Meanwhile, Marc, in the van, had one last trick. He sent a fake radio message to the guards, redirecting them to a false location. The ruse worked. The guards, now in disarray, moved away from Jean’s location.
Léa, having subdued her opponents, quickly joined Jean in the alley. They raced to the van, where Marc waited, engine running. As they drove away, the Eiffel Tower, majestic and unyielding, stood witness to their audacious feat.
Back in their safe house, the team celebrated. The AI device, now in their possession, was a testament to their skill, courage, and the fine line they walked between triumph and disaster.
They had succeeded against all odds, pulling off a heist that would be talked about in the underworld for years to come.
In the heart of Paris, under the gaze of the Eiffel Tower, they had not just stolen an object; they had stolen a moment in time, a moment that defined their lives and showcased the art of the impossible.
Final Thoughts: How to Write a Heist Scene
Just like a master thief meticulously planning a heist, dive into crafting your scene with precision.
And don’t forget to check out more writing tips on our website.
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Politics President invites heads of parties to Luncheon for Chinese PremierMay 16, 2013
Islamabad: President Asif Ali Zardari has invited heads of all the political parties to a Luncheon in honour of the Chinese Prime Minister Mr. Li Keqiang at the Aiwan-e-Sadr on May 22.
The Chinese Premier Mr. Li Keqiang is reaching on a two days state visit to Pakistan on May 22 on the invitation of President Asif Ali Zardari.
The Chinese Premier Mr. Li Keqiang on his arrival at the Presidency will hold one on one meeting with President Asif Ali Zardari followed by a delegation level talk between the two countries.
Spokesperson to the President Senator Farhatullah Babar said that besides others invitees, the heads of parties who have been extended invitations for the Luncheon hosted in honour of the Chinese Premier at the Presidency included PMLN President Mian Muhammad Nawaz Sharif, Chief of PTI, Imran Khan, Chaudhry Shujaat Hussain of PMLQ, Dr. Farooq Sattar of MQM, Mr. Asfandyar Wali Khan of ANP, Mr. Munawar Hasan of JI, Maulana Fazlur Rehman of JUI F, Mr. Aftab Ahmad Khan Sherpao of QWP, Sardar Akhtar Jan Mengal of BNP, Mr. Mahmood Khan Achakzai of PKMAP, Senator Dr. Abdul Malik Baloch of NP, , Mr. Ghulam Murtaza Khan Jatoi of NPP, Pir Sibghatullah Shah Rashdi-Pir Pagara of PMLF, Mr. Shahram Khan Tarakai of AJIP, Sheikh Rashid Ahmed of AML, Mr. Ijaz ul Haq of PMLZ, Mr. Muhammad Ali Saif of APML and Mir Israrullah Khan Zehri of BNPA.

domain: politics


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(Eagle News)–President Rodrigo Duterte on Friday, June 21, vowed to discuss the South China Sea dispute in the 34th Association of Southeast Asian Nations summit in Thailand.
“Can you claim a whole ocean? Because nobody can prevent America from claiming a third of the Pacific Ocean,” Duterte said in a speech in Davao.
He was referring to China’s expansive claim over the South China Sea through the so-called nine-dash line.
In 2016, the Permanent Court of Arbitration ruled China had no historic rights to the disputed waters as it claimed, but China refused to abide by the ruling.
President Duterte, during whose time Philippine relations with China became warmer, set aside the ruling, saying there was a proper time to raise the same.
Only recently though, the Department of Foreign Affairs filed a diplomatic protest against China after a Chinese vessel hit a Philippine fishing boat near Recto Bank, sank the boat, and abandoned its crew.
China has proposed a joint probe into the incident, but Foreign Affairs Secretary Teodoro Locsin Jr. has refused.
“I will talk lengthily about it dito sa ASEAN. It’s not a matter of yung nine-dash line. Simple lang. Can you claim an ocean as your own? Tell me now because I will also claim mine,” Duterte said.

domain: law


VIDEO: CalWave’s Wave Carpet device
CalWave is developing a wave energy converter whose design is inspired by the ability of muddy seafloors to effectively absorb overpassing ocean waves.
Researchers participating in CalWave project came up with the idea of using a viscoelastic carpet of wave-energy conversion (CWEC) placed over a network of vertically oriented springs and generators on the coastal seafloor.
The flexible carpet responds just like mud – as waves pass overhead, they induce dynamic ripples and undulations in its sprung surface, and these perturbations can be used to generate electricity.
The principle components of the prototype consist of a synthetic seabed carpet, a direct physical connection, a hydraulic power take-off system and a mooring system.
The energy stored in overtopping waves is damped out by the absorber carpet and converted into hydraulic energy using double reacting reciprocating pumps which are connected to the carpet.
The CalWave team collaborates closely with the Theoretical and Applied Fluid Dynamics Laboratory (TAFLab) at the University of California, Berkeley. TAFLab is lead by professor Reza Alam, who developed the original idea for the Wave Carpet.
According to Bloomberg, CalWave is developing two versions of its wave system – one that powers a hydraulic motor to produce power, and the other where the pistons pump seawater through the membranes of a desalination plant.
CalWave plans to deploy 80 kW prototype wave plant off San Diego late this year that would have the capacity to power 180 homes, Bloomberg reports.
Take a look at the video featuring more detailed explanations of Wave Carpet’s operating principles.


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- Distance to Ohrid city center: 9 km (6
- Low cost carriers served: 0
- Website: ohd.airports.com.mk
About this airport
Ohrid Airport is named after "Ohrid St. Paul the Apostle," and serves the city of Ohrid, Macedonia.
Ohrid Airport is located 9 km (6 miles) outside the Ohrid city center.
Taxi: Taxis arrive at the airport according to flight schedules.
In the terminal, there is an information desk, a restaurant, and one duty-free shop.

domain: travel


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Exhibition: Urbis Has Left The Building: Six Years of the Best Exhibitions In Pop Culture, Urbis, Manchester, until February 27 2010
“Best of” compilations are usually the preserve of the music industry. So if any museum has the shows to get away with the same trick, it would have to be Urbis.
Manchester’s poppiest gallery space is celebrating its short history with a final show, Urbis Has Left The Building: Six Years Of The Best Exhibitions In Pop Culture.
Since 2004 the city centre museum has staged shows on everything from graffiti and record design to manga and video games. But from 2011 the venue will be given over to an even more popular pastime as the National Museum of Football moves down the road from Preston.
Urbis Chief Executive Vaughan Allen said he was proud to have quickly established a global reputation with the museum. “No other . . . has provided popular culture with a serious platform in the way that we have, with a genuine passion that made us unique, consistently giving credibility and backing to subjects that most galleries and museums would overlook,” he commented.
Many Urbis shows have been celebrations of local talent, including graphic designer Peter Saville, fashion designer Matthew Williamson and record label Factory.
Other shows have looked as far afield as China and the US civil rights movement for inspiration; Black Panther: Emory Douglas and the Art of Revolution was rated one of the best of the decade by Museums Journal.
This will be your last chance to visit Urbis. And where else could you go to view a pair of limited edition Haçienda nightclub trainers?
Published on Culture24
David Blandy – Fortress of Solitude, 176 / Zabludowicz Collection, London, until Summer 2010
Strap on the artificial guitar and fire up the games console and you are ready to enter David Blandy’s world. It is indeed, as he demonstrates, a stage. We find our truth in the roles we play.
Guitar Hero is just part of it. Fortress of Solitude includes a library of games, books, comics, films and records which invite the viewer to load up, read, or put on different mass culture artefacts. Each carries a Soul Archive label as if a piece of Blandy’s very essence.
His influences, and the show is about nothing else, are eclectic. They include Kafka and Joyce, but also Marvin Gaye and EPMD. Martial Arts seem to tie the whole lot together as the sphere where hip hop, video games and of course film collide. Way of the Samurai is the subtitle of both a book (Mishima) and a movie (Jim Jarmusch).
It could also reference Blandy’s longest running video pieces. Soul of London, Soul of the Lakes and The Five Boroughs of the Soul all star the artist in an orange kung fu suit, with staff and portable record player. Each one documents a quest or in search of truth or the meaning of soul. On the subway in New York, a barefoot Blandy explains to a bemused local that he is doing a penance.
In the Bronx, he risks getting shot. In London, he risks mockery. In Cumbria, he risks cut and bruised feet. But each film is cut and spliced with clips from the music and the movies the film-maker loves. So they combine postmodern hyperreality with real endurance, an intriguing mix.
The artist also puts himself on the line with emotive lip-synced performances of hip-hop, reggae, funk and soul classics. In Hollow Bones he even mimes along to a Syl Johnson track called Is It Because I’m Black? Blandy by the way is, apparently, not.
That could mean his performances are as hollow as the bones in the film’s title. Or it could mean that they are still bones, still the structure of his existence.


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Distinguishing Between Dietitian and Nutritionist
Dietitians and nutritionists are both food and nutrition experts. They’ve studied how diet and dietary supplements affect your health. Both are considered to be healthcare professionals, but the two titles can’t be used interchangeably.
According to the Academy of Nutrition and Dietetics in the United States, a registered dietitian has accomplished the following:
- Earned a bachelor’s degree with coursework approved by the Academy of Nutrition and Dietetics’ Accreditation Council for Education in Nutrition and Dietetics at a US regionally accredited university or college.
- Completed an ACEND-accredited supervised practice program at a health-care facility, community agency, or a foodservice corporation or combined with undergraduate or graduate studies. Typically, a practice program will run six to 12 months in length.
- Passed a national examination administered by the Commission on Dietetic Registration.
The letters R.D. (registered dietitian) or R.D.N. (registered dietitian nutritionist) after their names.
- Complete annual continuing professional educational requirements to maintain their registration.
Registered dietitians may plan food and nutrition programs and promote healthy eating habits to prevent and treat illness. They often work in food service or as part of medical teams in hospitals, clinics, and other healthcare facilities. Dietitians also work in university settings, where they may teach, do research or focus on public health issues.
Many people mistakenly use the terms “dietitian” and “nutritionist” interchangeably. Although these two professions are undoubtedly related, they maintain distinctive qualities. The biggest difference between dietitians and nutritionists lies in the legal restrictions that each title carries. Only nutritionists that become registered with Commission on Dietetic Registration (CDR) may legally declare themselves as dietitians or more precisely, registered dietitians (RDs).
What does a Registered Dietitian do?
A nutrition and behavioral assessment provides the basis for the Registered Dietitian’s intervention. This assessment includes evaluation of the patient’s diet and lifestyle habits including:
- Meal frequency and hydration status
- Nutrient excesses and deficiencies
- Food allergies and intolerances
- Nutritional biochemical assessment
- Digestive issues
- Supplement use
- Weight and medical history
- Activity level
- History of emotional eating in response to pain, fatigue and stress
- Food shopping, cooking and restaurant habits
- Family and social support/influences
- Readiness for change
The Registered Dietitian assesses each patient to determine if their diet contributes to symptoms, abnormalities, or chronic diseases or conditions in a patient. These may include: overweight or obese status, heart disease, diabetes or osteoporosis.
Some Registered Dietitians specialize in food sensitivities and may prescribe elimination or exclusion diets to determine if there are any specific foods that may exacerbate symptoms and digestive issues. The Registered Dietitian also addresses emotional eating issues, which may arise in response to chronic pain and fatigue. Weekly or bi-monthly support is often recommended to help the patient achieve nutrition goals.
The Registered Dietitian can become an integral part of the health care team, and can provide information about dietary issues that can guide health care professionals in their treatment, management, and interaction with the patient.

domain: food


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Today I will show a very simple ionization chamber that can detect radioactivity. I was able to detect with it ionizing radiation from a smoke detector (Am241 isotope). It's also immune to electromagnetic interference (EMI) due to a good shielding.
This device doesn't explicitly use any power supply. It's connected to a multimeter set to measure resistance, in this mode, the multimeter provides a small voltage to its probes (R=I/U, so to measure resistance, it has to put voltage across measured element). This is sufficient here, because basically we just need to polarise electrodes of the ionization chamber and nothing more. My multimeter provides 5.6V in this mode.
My setup is presented below, note that the sensor is this metal box, not the PCB visible on the image.
The chamber is made from copper plate soldered carefully to prevent any holes where electromagnetic fields could flow and disturb readings. Inside is one BF256B (n-channel J-FET) transistor, its gate is connected to one of ionization chamber plate made from a leg of a THT resistor, source pin is available externally, this is where "plus" probe of the DMM is connected, drain is connected to the metal case (that is both and electrode and is shielded against EMI).
I've used Keysight 34460A as a multimeter here, because it has histogram mode, that will be useful to look if the measured value is stable over time. PLC was set to 0.2, it will reduce accuracy, but will give much more samples.
Below two images present what is inside of the sensor (only JFET, as mentioned above) and the sensor mounted. The front was shielded using tin foil, that was secured tightly by insulation tape.
There are many movies on YouTube with people constructing ionization chambers, however, those aren't shielded completely and due to high wideband gain in those circuits, they will pick-up any electromagnetic radiation, so the results aren't very useful.
Those designs measures not only ionizing radiation, but also whole electromagnetic spectrum. Here I tried as a dummy test to place the a metal object to check if the measured value won't change, without a shielding it would probably be a big peak.
Time to show results. The resistance decreases when the amount of ionizing radiation increases, below you can see two peaks on the histogram, one on the left is when the sample (Am241 isotope) is present next to the sensor, on the right, when there is no sample.
I think, that it's a very interesting circuit, and can be used for example to understand how different shielding prevents radioactive radiation, etc. It's limited, but a good start to making own ionizing chambers.


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Cellphones don't cause brain cancer
Here is some good news. It is now official that cellphones don't increase the risk of brain cancer. A study has found that there is no link between brain tumour and the use of cell phones.health and fitness Updated: Dec 05, 2009 14:20 IST
A long-term study has found there is no link between brain tumour and the use of cell phones. The study among Scandinavian people from 1974 and 2003 has found that the use of cell phones did not increase brain tumour risk among users.
"We did not observe (notice) an effect of mobile phones on the incidence of brain tumours,'' study leader Isabelle Deltour of the Institute of Cancer Epidemiology in Copenhagen told a Canadian television network. As part of this extensive study, 16 million people in Finland, Denmark, Norway, and Sweden were tracked for what happened to rates of glioma and meningioma brain tumours among them over 30 years.
But the researchers found that only 60,000 of them developed brain tumours. This rate of brain tumour was not higher than that seen before the use of cell phones began. The study found that there was no increase in risk. If there was any increase in risk, it was too small to be observed or the period needed for cell phones to cause brain tumours was longer than the period studied.
The Scandinavian study commenced just when cell phones were introduced.
"If there was a connection, we would have expected a sudden marked increase in the rates, especially among younger males, which were the first to use cells phones.We didn't see that,'' Deltour said.
However, the researchers stressed that more longer-term studies are needed to prove that the use of cell phone does not raise the risk of brain cancer. They said they will continue monitoring to see if it takes longer to detect changes in tumour rates.
Another international study on the link between cell phone use and brain cancer is likely to come out next year.
The Scandinavian study has appeared in Journal of the National Cancer Institute.

domain: news


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FCM Versus R-FCM Followed by R-Maintenance or Observation Only
This trial is active, not recruiting.
|Conditions||lymphoma, follicular, lymphoma, low-grade, lymphoma, intermediate-grade|
|Treatments||fcm, r-fcm, rituximab maintenance, observation only|
|Sponsor||Ludwig-Maximilians - University of Munich|
|Start date||November 1998|
|End date||June 2001|
|Trial size||319 participants|
|Trial identifier||NCT00317096, NHL-1998-1|
The aim of this phase III trial is to assess the safety and efficacy of treatment with rituximab in combination with FCM chemotherapy (R-FCM) versus FCM chemotherapy alone for remission induction and to asses the safety and efficacy of rituximab maintenance versus observation only after response to induction therapy. Both questions are addressed in way of a prospective randomized comparison in patients with relapsed FL, MCL and LP lymphoma.
|Endpoint classification||efficacy study|
|Intervention model||factorial assignment|
Event free interval
Time to Progression
serious infectious complications
Male or female participants at least 18 years old.
Inclusion Criteria - patients with histologically proven stage III/IV centroblastic/centrocytic (FL), centrocytic (MCL)or lymphoplasmacytoid lymphoma (LPIC). - relapsed disease after initial chemotherapy or peripheral blood stem cell transplantation - two-dimensionally measurable lesion outside a previously irradiated area (osteoblastic bone lesions, ascites, and pleural effusions are not evaluable) - age > 18 years - Karnofsky-index > 60 - life expectancy of at least 3 months - effective contraception in female premenopausal patients - patient's written informed consent Exclusion Criteria: - age < 18 years - Karnofsky-index < 60 - treatment with fludarabine or mitoxantrone within the preceding three months - active auto-immune hemolytic anemia at the start of FCM chemotherapy - participation in another clinical trial during the last 4 weeks - participation in this study before - previous treatment with murine antibodies - concurrent diseases which exclude the administration of therapy as outlined by the study protocol - non-compensated heart failure - dilatative cardiomyopathy - coronary heart disease with ST segment depression in ECG - myocardial infarction during the last 6 months - chronic lung disease with hypoxemia - severe non-compensated hypertension - severe non-compensated diabetes mellitus - renal insufficiency (creatinine > 2.0 mg/dl), not related to lymphoma - hepatic insufficiency with transaminase values greater than 3-fold of normal values and/or bilirubin levels > 2.0 mg/dl, not related to lymphoma - clinical signs of cerebral dysfunction - women during lactation or pregnancy or of childbearing potential not using a reliable contraceptive method - severe psychiatric disease - serological positivity for HBV, HCV, HIV - previous organ transplantation other than autologous peripheral blood stem cell transplantation - missing written informed consent or missing written consent for data protection
|Official title||Treatment of Relapsed CBCC, CC and LPIC Lymphoma With FCM Chemotherapy Alone or in Combination With the Monoclonal Anti CD 20 Antibody Rituximab Followed by Anti-CD 20 Maintenance or Observation Only|
|Principal investigator||Hiddemann Wolfgang, PhD|
|Description||Patients with relapsed centroblastic/centrocytic (FL), centrocytic (MCL)or lymphoplasmacytoid lymphoma are randomly assigned to either FCM chemotherapy alone or to FCM chemotherapy in combination with the monoclonal anti-CD20 antibody rituximab (R-FCM). FCM chemotherapy will be given for 4 cycles in intervals of 4 weeks. In patients assigned to cytoreductive therapy with FCM plus rituximab, the monoclonal antibody is given as one infusion (375 mg/m2) on the day before the respective FCM course for a total of four applications. Four weeks after the end of FCM chemotherapy patients with CR or PR are randomly assigned to either no further treatment or maintenance therapy with rituximab. Rituximab will be given 4 times (one infusion per week with 375 mg/m2). After six months rituximab treatment will be repeated with another 4 infusions. In case of relapse patients will receive an alternative treatment according to the decision of the investigator. The aim of this phase III trial is to assess the safety and efficacy of treatment with rituximab in combination with FCM chemotherapy versus FCM chemotherapy alone for remission induction and to asses the safety and efficacy of rituximab maintenance versus observation only after response to induction therapy. Both questions are addressed in way of a prospective randomized comparison in patients with relapsed FCL, MCL and LP lymphoma. Primary objectives of this trial are to compare (1) the remission rates (CR and PR) achieved after FCM plus rituximab versus FCM alone and (2) the progression free interval of rituximab maintenance versus observation only.|
Call for more information

domain: medical


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Bitcoin and Gold: Evaluating Hard-Cap Currencies in Times of Financial Crisis
2020. Mar. 23. 22:21
How would a bitcoin economy react to coronavirus? For now, we don’t know. However, we can turn to a proxy for insight: gold.
comments powered by Disqus.


text: Researchers have broken into an iPhone 4S running the latest version of Apple iOS, making it possible to exploit the same vulnerability in the iPhone 5 that is set for release on Friday.The white-hat hackers Joost Pol and Daan Keuper showed how they were able to steal contacts, browsing history, photos and videos to win $30,000 in the mobile Pwn2Own contest Wednesday at EUSecWest in Amsterdam, IT World reports.Because the hacked iPhone was running a developer version of iOS 6, it's likely the same vulnerability could be used to break into an iPhone 5 or the latest iPad and iPod Touch devices.\u00a0The WebKit browser exploit took only a few weeks to make, the researchers told IT World. \u00a0Using the malicious code in a website would enable a cybercriminal to bypass the security mechanisms in Safari to gain access to the phone's data.WebKit is a layout engine used by browsers to render Web pages. The open source technology is used in the Safari Web browser in iOS and in Google's Chrome, which recently became the default browser for Android.[See also:\u00a05 policy questions for mobile device security]The Dutch researchers are not the first penetrate the iPhone's defenses through WebKit, said Chenxi Wang, an analyst for Forrester Research. Hackers typically target WebKit because Apple does not use a number of standard security practices in using the engine.Apple has not said why, but it could be related to phone performance and battery life. In addition, Apple doesn't vet code executed on the browser, like it does apps before allowing them to be offered to iPhone users."This opens doors to remote exploitation," Wang said. "But to [Apple's] credit, we haven't seen a lot of that going on, which is actually quite impressive."Wang does not believe the risk of the latest vulnerability is very high. That's because a cybercriminal would have to find a way to get iPhone users to a compromised site. A hacker could inject malicious code into a popular Web site, but this would also be difficult."It's certainly possible and certainly is a threat, but I don't see it becoming a massively popular way of attacking iPhone users," he said.The Dutch researchers held back some of the details of their work, in order to prevent giving cybercriminals a hacking roadmap to the iPhone."Apple will have to come up with an update and then people need to upgrade as fast as possible," Pol told IT World.\u00a0Speed in plugging the hole is key to reducing risk, said Peter Bybee, president and chief executive of cloud security provider Security On-Demand."Whether you're likely to be attacked depends on how long the gap will be between when Apple fixes the problem and attackers repeat the researcher's success," Bybee said. "Just because the exploit is shared only with the vendor doesn't mean that it won't get out into the open market. There was enough detail in how they found the exploit and used it that it could be replicated by an experienced malware creator."Other participants in the hacker contest demonstrated breaking into the Samsung Galaxy S3 via its near field communication (NFC) technology. The researchers from security company MWR Labs were able to beam an exploit from one Galaxy S3 to another.Once the malicious app is installed in the receiving phone, a hacker would have full access to the phone's data, Tyrone Erasmus, a security researcher at MWR told IT World. The app runs in the background, making it invisible to the phone's user.The exploit targets a vulnerability in the document viewer application that comes as a default app in the Galaxy S2, S3 and some HTC phones. The flaw enables a hacker to steal text messages, emails, contact information and other data.The researchers said the vulnerability, which also exists in the Galaxy S2, could be exploited by malware sent via email, the MWR team said. The researchers also won $30,000 for the hack.Zero Data Initiative by Hewlett-Packard's DVLabs organized the competition. DVLabs will send details of the hacks to Apple and Samsung, respectively.


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third world county
"In a democracy (‘rule by mob’), those who refuse to learn from history will be the majority and will dictate that everyone else suffer for their ignorance."
(From FB–before that I know not.)
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MIDDLETOWN — Old hat conveys the notion that something is predictable to the point of being boring. It also can be wrongly cited when it comes to the Xavier wrestling team that something familiar is out of fashion.
— Bill Bloxsom (@blox354) February 16, 2020
Xavier sent eight athletes to the finals, with five winning the first-place medals, and the Falcons took home their fourth consecutive Southern Connecticut Conference championship on Saturday at Mercy High.
Xavier took control in the semifinals and consolation quarterfinals on its way to posting a score of 210.5 for a healthy margin of victory.
East Haven, Branford and Foran battled for runner-up, with the Easties (146.5) second, Hornets (140) third and Lions (137) fourth.
Xavier had won leagues eight out of nine years, with Foran taking the title in 2016 (the 2013 meet was cancelled due to weather).
Could there be a letdown?
“I could tell how they were thinking (about SCCs) with how testy they were at practice this week,” Cunningham said. “It was a good testy. They feed off each other, they push each other and they care about each other.”
“It isn’t generally known, but 10 of our starters are homegrown kids,” Cunningham said. “We have nine seniors and all but one (170-pounder Ryan Minor) has been with us from the beginning. (Senior) Will Cullen is usually at 220, but for the good of the team he moved to heavyweight today to get us any team points he could (heavyweight Malcolm-Wilson Toliver is out with the flu).”
The Falcons’ James Lunt, who repeated as 145-pound champion, knows how much it took for his team to win the league all four of his seasons.
“It is crazy to think about, but it feels amazing,” said Lunt, who will wrestle next season at Division I Campbell University in North Carolina next year. “We have a great group of guys. We love to have fun together, but we know when it is time to go to work.”
This was Lunt’s third title. He was runner-up as a freshman.
— Bill Bloxsom (@blox354) February 15, 2020
East Haven’s Dominic Miliano, with the 106-final tied at 3-3, pinned Foran’s Antonio Madero in 5:28.
“Excited to take second place in the SCC against all these powerhouse teams in the SCC,” Miliano said. “It this feels pretty good (to win). I kept my head in and ended up pinning.”
Xavier’s Michael Rapuano pinned John Fernandes from Guilford in 1:03 to win at 113. Unbeaten in in-state matches, Rapuano was the 106 champ as a sophomore.
At 120 pounds, North Haven’s freshman Joe Iamunno won by 15-0 technical fall over Xavier sophomore Colin Loria, who was third at 113 a year ago.
Defending champion Tommy Manganiello from Xavier, down 5-3, pinned East Haven’s Mathew DiVito with 18 seconds left at 126 pounds. DiVito was the 120 champ as a sophomore.
At 132 pounds, Foran’s Kyle Pokornowski pinned East Haven’s Alec DiVito in 1:52. DiVito was fourth at 132 and Pokornowski was third at 120 a year ago.
Louis Bradley from Morgan won the 138-pound title by 50-second fall over East Haven’s Tanner DiVito. A junior, Bradley (38-1) was SCC champ at 132. DiVito (38-3) was second at 138 last season.
At 145 pounds, Xavier’s James Lunt defeated Fairfield Prep’s Henry Bosken by 21-5 technical fall. Bosken was second at 126 in 2019.
At 152 pounds, Xavier’s Quinn Moynihan escaped in the closing seconds to secure a 6-5 victory over Foran’s Ethan Edmondson.
— Bill Bloxsom (@blox354) February 16, 2020
Prep’s Dean Tsiranides pinned Xavier’s Luke Tischio at 160 pounds.
Ryan Miner from Xavier posted a 7-1 victory at 170 over Guilford’s Christopher Murphy.
At 182, Justin Osler (26-0) from Branford repeated as SCC champion with an 11-7 win against Amity’s Simon Flaherty (35-1).
Branford’s Colin McHenry (39-0) pinned Xavier’s Marcelious Ruiz (18-2) in 1:56 of their 195-pound final. McHenry placed second a year ago at 195.
McHenry said: “It’s been a fantastic season. To set the school record for wins (134) here at the SCCs was great. We established a solid team this year.”
At 220, Notre Dame-West Haven’s Jackson Paulishen defeated East Haven’s Gunner Horton, 8-0.
Shelton heavyweight Matt Weiner defeated Branford’s Minsik Lee, 8-3. Weiner (34-1) was second at 220 a year ago.
Most Outstanding Wrestler Joe Iamunno from North Haven won the 120-pound title as a freshman and a team of one.
“It was unexpected,” said Iamunno, who wrestles with Notre Dame-Fairfield. “I’m grateful to be here, I just need to thank my teammates and partners in the room. I’ve been wrestling since I was four. I love it. I’ll be training later to go to Fargo (for Nationals).”
Five wrestlers returned looking to win another title. Michael Rapuano (Xavier), Tommy Manganiello (Xavier), Louis Bradley (Morgan), James Lunt (Xavier) and Justin Osler (Branford).They all triumphed.
“My kids wrestled amazingly well,” East Haven coach Mark Tolla said. “We brought 11 kids, and left the younger ones home. Xavier was propable out of reach, but to go for second is all because of how hard the kids worked.”
Alec DiVito and Mat DiVito each entered the finals with 94 career wins. Called an over achiever by twin bother Alec, Tanner had 95 victories.
Branford sent two to the finals — defending champion Justin Osler at 182 and Cody McHenry at 195.
“Cody had 134 wins going in, one off the school record,” Hornets’ coach Jesse Hurlburt said. “Justin is the defending champion.”
Branford went 26-1 in the dual meet season. It was 19-10 in duals a year earlier.
“For a long time we’ve been the Little Brother,” Hurlburt said. “We’ve had a champ here and there, but this is the second year we’ve been able to put a full lineup on the mat. I’m so proud of these kids. It is nice to be engaged with them every day and know they learn in the practice room and take it to the mat with them.”
Foran had three finalists Antonio Madero (22-3) at 106, Kyle Pokornowski (38-4) at 132 and Ethan Edmondson (39-3) at 152.
“We knew we would be in the mix,” Lions’ coach Dave Esposito said. “Antonio has done great as a freshman. Kyle is a sophomore and had placed third as a freshman. Ethan was third at 152 as a sophomore.”
Final Team Results
1. Xavier, 210.5; 2. East Haven, 146.5; 3. Branford, 140; 4. Foran, 137; 5. Guilford, 101; 6. Daniel Hand, 65.5; 7. Fairfield Prep, 61.5; 8. Amity Regional, 46.5; 9. Shelton, 43; 9. New Haven, 43; 11. Notre Dame, 39; 12. Morgan, 33; 13. North Haven, 23.5; 14. Jonathan Law, 11; 15. Cheshire, 10

domain: sports


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Elan Ruspoli and husband of Jacqueline MacInnes Wood Wedding
Elan Ruspoli is a talent agent for Creative Arts Agency in the United States. He is famous for being married to the Canadian actress Jacqueline MacInnes Wood. Wood has won many awards as an actress, and her part as Steffy Forrester in CBS’
Early Life of Elan Ruspoli
Elan Ruspoli was born in Beverly Hills, California, on 17th August 1985. . Jacqueline wished him on Instagram on 17th August 2018 with the caption, “Happy Birthday to my man @elanruspoli. An incredible ride so far.
Moreover, she also gave the caption, “Happy Birthday @elanruspoli! I am lucky to have you.”
Elan keeps his life private and does not share too much about his personal life. His birthplace is Beverly Hills, California. In his family members, we just know the names such as Lisa Zepeda, Charlotte Cheshire, James Mannino, Atlas Hurley, and Rafael Aviv.
His family is the most respected aristocratic family in Rome and originally came from Florence, Italy.
- Full name: Elan Ruspoli
- Date of birth: 17 August 1985
- Place of birth: Beverly Hills, California,
- Gender: Male
- Age: 37 years
- Profession: Talent agent
- Current residence: United States of America
- Nationality: American
- Ethnicity: White
- Religion: Christianity
- Zodiac sign: Leo
- Sexuality: Straight
- Wife: Jacqueline MacInnes Wood
- Children: 4
- School: Beverly Hills High School
- College: University of South California
- Height: 5 feet 10 inches
- Weight: 64kg
- Eye color: Brown
- Hair color: Dark brown
Elan is an agent at Creative Agency of Los Angeles. He is not an actor, as some reports said he had been involved in the movie industry, but that’s not true. However, he had the credit for many movies such as Them That Follow, The Burnt Orange Heresy, Possessor, In the Shadow of The Moon, and many more.
Elan Ruspoli and Jacqueline MacInnes Wood Wedding and Dating Life
No one know where they met the first time. However, after a year of dating, they engaged in November 2017; she announced this good news on social media.
They got married in August 2018 during the B&B Summer hiatus. Elan and Jacqueline Macinnes Wood’s wedding was held in Italy.
She said, “we went to Italy for summer, and that was perfect timing for our family and friends. We ended up meeting on a yacht, and one of my friends who was there officiating the wedding, okay, let’s do this.”
Now the couple has four children; Rise Harlen, their first boy, was born in March 2019.Lenix, their second son, was born in February 2021. Brando, their third son, was born in May 2022. And Valor, their fourth child, was born on August 27, 2023.
As of 2023, Elan Ruspoli is thought to have a net worth of $1 million. He made his fortune through his Creative Artist Agency.
The company gives its workers an average of $73k a year.

domain: celebrity