text:
Right now, there is no visible indication More teams will be headed to the California capital.
Sacramento Mayor Darrell Steinberg wants more big-league sports teams in his city. Presently, only the National Basketball Association’s Kings franchise is the only major league franchise that calls Sacramento home. But Steinberg is hopeful that the 20th biggest American television market will be able to perhaps get a Major League Soccer franchise or a Major League Baseball team. It is unlikely that Sacramento can land a National Hockey League team for the same reason that Phoenix and Brooklyn failed. The arena was built for basketball not hockey and that, of course, limits the number of events that the city-owned building can have. Sacramento officials want a chance at getting a Major League Baseball franchise and a Major League Soccer team. Sacramento was awarded an MLS expansion franchise in October 2019. But Ron Burkle, who would have provided a significant chunk of the expansion fee dollars and stadium construction money, backed out of the ownership group and eventually MSL owners pulled out of Sacramento.
“The people of Sacramento are hungry for more,” Steinberg told The Sacramento Bee newspaper. “Being a great city and building a great city is about creating more opportunities for joy or opportunities for people to come together. We want more sports and we want more professional sports franchises. Absolutely. The question is how to attract more major league sports in a way that is compatible with a limited city budget, a stressed city budget, and the rightful public insistence that we don’t use city general fund money to make it happen.” That is a problem that sports franchise owners and elected officials are facing. Getting public money for a venue that will be used by a private business. In Sacramento there is another problem. Finding potential owners. There could be a soccer stadium on the horizon but MLB and NHL teams aren’t coming to Sacramento.
Evan Weiner’s books are available at iTunes – https://books.apple.com/us/author/evan-weiner/id595575191
Evan can be reached at email@example.com

domain: sports


text:
Just before Labor Day, the square baler was pulled out of the shed, greased and
oiled, and sent to the field for what almost seems like an outdated practice.
The making of small square bales is a might more tedious than
driving the big round baler down the field.
You have decisions to make on the size of the
bale and the tension of the string. It proves that there is an art
to farming and a lot of patience and praying with each bale
that scoots out the shoot!
With the help of the hay accumulator, a skid loader,
and a long trailer, the job of storing the hay is greatly
improved from the days of a hay hauling crew that
bucked each bale on the trailer in the field then
unloaded and stacked them in the barn on
a 100 degree summer day.
I'm thankful for all the modern machinery that
makes it possible to produce food for our calves and cows,
for the rain that we have been blessed with in this
late summer season,
for these farm dogs that love life on the farm!

domain: agronomy


text:
A bike race that takes place in the French Alps every year called the "Mountain of Hell" had a massive pileup soon after it started on Sunday. Luckily, there were no major injuries. There are 700 riders that start the race at the same time! They start traveling down a snowy glacier when all it took was one guy to fall which caused the big chain reaction! The race itself is a 15-mile course of snow, ice, rocks, and dirt. The guy who won it this year was clocked at 78 miles per hour going down the mountain.
Content Goes Here

domain: geography


text:
Lightning-laced thunderstorms rolled through Tarrant County late Tuesday into early Wednesday, drenching much of the area.Rainfall at Dallas/Fort Worth Airport totaled 1.97 inches through 10 a.m. Normal rainfall for the area for Aug. 1-15 is .97 inches, according to National Weather Service data.Weather service radar indicated rainfall totals of 2-3 inches for much of northeast Tarrant County since the storms began Tuesday evening. A flash flood warning expired at 7 a.m. for that area.Most of the county received at least an inch of rain, radar indicated. Some areas of southern Wise County and southwest Denton County had received up to five inches. Justin in southern Denton County reported 4.86 inches of rain, according to NWS figures.Oncor, which delivers electricity for much of North Texas, was reporting about 2,000 customers without power in Tarrant County at 7 a.m. Another 28,000 customers were without power at that time in Dallas County, said Arielle Kaplan, an Oncor spokeswoman. Those figures were down to about 1,700 in Tarrant County and 6,600 in Dallas County by 11 a.m."Rain is still falling but crews are out there restoring power," Kaplan said Wednesday morning.Anyone without power should contact Oncor at 888-313-4747.Weather service meteorologist Dan Huckaby said that light rain and showers could continue until late Wednesday morning, and possibly into the early afternoon."For August, we average two inches of rain in the area," Huckaby said Wednesday. "Some places got that and more just overnight."The storms moved into Tarrant County about 8 p.m. Tuesday and "averaged two to three [lightning] strikes per minute," said Nick Hampshire, another weather service meteorologist."A stalled frontal boundary over the Metroplex and an upper level disturbance combined together to develop the thunderstorm," Hampshire said.The lightning was accompanied by heavy winds and downpours and brought some heat relief as the temperature dropped into the 70s.Tuesdays high of 106 tied the record for the date set in 1911.The heavy rain helped completely douse grass fires in Fort Worth that developed Tuesday afternoon. The fires were on Angle Avenue, North Riverside Drive and North Tarrant Parkway.By 6:30 p.m. Tuesday, all were under control and firefighters were "mopping up," battalion chief Richard Harrison said.The weather service's Fort Worth office had a clear view of one of the fires and posted a photo online.The forecast calls for temperatures in the upper 90s Wednesday and Thursday, but a cool front should arrive Thursday night and with it a 30 percent chance of rain.The high on Friday during the day will be in the mid-90s and should be a bit lower for the weekend.Forecasters are calling for rain chances for most of the weekend.
Domingo Ramirez Jr., 817-390-7763; Twitter: @mingoramirezjr.

domain: news


text:
This means that the poor has much less access to quality fuel for cooking. Income poverty thus translates into energy poverty.
Bangladesh is betting on coal to support its fast growing economy, even as other countries in Asia try to shift away from the dirty fuel amid an intensifying pollution crisis.
The minister said a 1, megawatt coal-fired plant was under construction in the newly built Payra seaport, with Chinese support. Another power plant, the 1, megawatt Rampal project in the Sundarbans, funded by India, would start to supply electricity by Protests against this power plant have been ongoingcosting a number of lives over the lives, with another set of protests happening at the end of last month.
Bangladesh has seen a swift upsurge in electricity usage.
Hamid told the parliament that daily power generation capacity has grown from 3, megawatts in to 15, megawatts by Renewable energy constitutes only 2.
The failed promise of renewables In Junethe Bangladeshi finance minister, Abul Maal Abdul Muhith, presented the national strategy on the energy sector in parliament. In earlytwo years after the deadline, to produce megawatts, Bangladesh has failed to meet its renewable targets, producing only megawatts.
Although we have successfully installed over four million solar home systems, we are beset with problems standing in the way of expanding the renewable sources.
He suggested that the government might be choosing to develop coal for national energy supply, rather than for households in remote areas.
Expanding wind power Although wind power accounts for only 0. The board also plans to expand on-shore wind power plants along the coastal regions of Bangladesh.
Shahidul Islam Khan told thethirdpole. To maximise the renewable potential, he said, Bangladesh could build hybrid projects that combine wind and solar. Kuakata beach had potential for wind and hybrid projects. Small hydropower could be another option.
Soul-searching and heartburn In the meanwhile, the expansion of coal as a source of energy has led to some soul searching, but given its affordability, the government fears it has no choice. This may also be because the assessment of costs has not factored in health and environmental impact of this huge increase in coal production.
Furthermore, as Ashfaqur Rahman, a former Bangladeshi ambassador to China, told thethirdpole.
But we are switching to a dirty source [coal]; we are building a coal plant near the world heritage site. The government should be careful about it because public health and environmental issues matter. State minister Nasrul Hamid claimed the Rampal power plant near Sundarbans would be built with the latest technology, which would reduce pollution from coal burning, in his recent speech in parliament.
This has been received with some scepticism. Anu Muhammad, who spearheads the civil society movement against Rampal coal fired plan t, told thethirdpole. Kamran Reza Chowdhury is a Dhaka based journalist.To meet the energy crisis Bangladesh has been experienced to renewable sources like biogas, bio-fuel, solar energy, wind energy, tidal energy, geothermal power, hydro power etc.
In this paper we have tried to analyze about renewable sources of the country. An energy crisis is any great bottleneck) (or price rise) in the supply of energy resources to an economy.
In popular literature though, it often refers to one of the energy sources used at a certain time and place. Electricity Crisis: To What Extent Organizational Inefficiency Bangladesh electricity supply industry is controlled by the centralized bureaucratic system of the Ministry of Power, Energy, and Mineral Resources (MPEMR) and its subordinate organizations Power Division and BPDB.
Energy Crisis in Bangladesh. Introduction: Bangladesh is one of the most densely populated countries with 79% of the population living in rural areas. The primarily agricultural economy of Bangladesh has recorded around 5% annual growth rate over the last few years (ADB, ).
The main crops grown in the country are rice and jute.
Crisis of Power in Bangladesh Electricity has given modern and sophisticated life in the world. It is impossible to imagine the civilized world with-out electricity. In Bangladesh the crisis of power is the com-mon phenomena.
Now a day it has become the serious prob-lem. The reasons for lower availability are (1) some plants. Electricity generation may come to a halt at the state-run Barapukuria coal-fired power plant anytime due to a coal crisis, a top official has said.
Two of the three units of the megawatt.


text:
Whenever you are choosing whether to accept and you will cure their aggressive puppy, you will find several a few as you, once the pet mother, is sooner guilty of the dog’s choices
- Size. Irrespective of other factors, higher pet much more scary and can cause more harm than just quick pets.
- Many years. Younger pet that have a hostility situation are believed become more malleable and much easier to relieve than more mature pets.
- Chew background. Dogs who possess currently bitten was a well-known chance and you can a keen insurance coverage liability.
- Severity. Pet whom end their violence within indicating white teeth, growling or snapping try notably easier to live and work on than just pets which bite. As well, pets who have introduced small bruises, damage and you may quick punctures are much safer than simply animals who possess inflicted really serious wounds.
- Predictability. Dogs within high danger of are euthanized to have hostility try people who bring http://datingmentor.org/escort/west-covina/ little alerting ahead of they chew and you can who are inconsistently, unpredictably aggressive. Animals just who provide warning before it chew allow it to be somebody and other pets time for you retreat and prevent delivering harm. As counterintuitive as it may have a look, it’s simpler to accept your pet dog just who constantly reacts aggressively whenever, such as, each time you push him off the bed than your dog that would therefore only from time to time.
- Aim. How frequently canine was met with the fresh new plans out-of this lady aggression make a difference how simple it’s to manage and you can handle the lady decisions. Your dog that competitive to help you strangers is relatively very easy to handle if you live within the a rural environment with a securely enclosed grass. A dog who has aggressive so you can students shall be handled if the her dogs moms and dads are childless and have no friends otherwise family which have people. Your pet dog who’s competitive to help you unknown pet presents nothing difficulties to possess animals mothers just who hate dog parks and you can choose do so its puppy into the isolated walking tracks. Having said that, living with a puppy who has repeated ear canal attacks and you can bites family relations once they just be sure to medicate the girl shall be exhausting and you may offensive.
- Produces. Certainly are the facts one to quick canine to behave aggressively effortless or impractical to end? Should your canine merely guards the lady restaurants whenever you are this woman is food, the answer is simple: Steer clear of her if you find yourself she’s food. If there is no-one to securely enter the cooking area when your pet’s truth be told there because she guards her blank dining pan in the cabinet, which is some other tale. When your puppy hits people stranger close at hand, she actually is significantly more dangerous than a puppy whom hits complete strangers only if it make an effort to hug the woman.
- Simple promoting canine. The final consideration is how effortless it’s to help you motivate their puppy during retraining. Brand new easiest and most effective way to treat a hostility state should be to use conclusion modification according to the suggestions of a professional top-notch. Modifying an effective pet’s choices involves satisfying the lady for good decisions-thus you’ll likely be much more profitable whether your dog has supplement, snacks and you will toys. Pet who are not including motivated from the typical benefits might be specifically difficult to run, therefore the likelihood of such as for instance your pet dog recovering is quick.
Constantly Focus on Their Veterinary
Certain competitive animals react how they create due to good health problem or side effect. Together with severe terrifically boring requirements, animals having orthopedic issues, thyroid problem, adrenal dysfunction, cognitive breakdown, seizure disorders and you can neurological deficits is display alterations in irritation and you will aggression. Geriatric pet can be suffer misunderstandings and you may insecurity, which may timely aggressive choices. Particular medications can transform mood and you can apply at your own dog’s awareness to aggression. Actually eating plan has been implicated while the a possible adding basis. If your puppy has an aggression disease, it is imperative to need her so you can a vet, before you could do anything otherwise, so you can exclude medical problems which could lead to otherwise worsen the lady choices. When your veterinarian learns a medical problem, you’ll want to work closely together with her giving canine a knowledgeable options at improving.

domain: pet


text:
|Connecticut Botanical Society|
Photos & Information
Red and Orange
Blue and Purple
Green and Brown
Plant ID Guides
Argentina anserina (Potentilla anserina)
The undersides of the leaves are silvery with fine hairs, hence the name silverweed. In the bottom photo, the leaf on the left has been turned upside down to display the silver color. Silvery cinquefoil leaves are also silver underneath, but the leaf shape is different.
To us, the flowers look solid yellow, but bees, which can see ultraviolet light, see them differently. In this ultraviolet image by photographer Bjorn Rorslett, a bull's-eye pattern is visible. Patterns visible in ultraviolet light help lead bees and other insects to the flower's pollen and nectar.
Family: Rose (Rosaceae)
next yellow flower
next in rose family

domain: biology


text:
US provides funding for UXO Lao
US provides funding for UXO Lao teams to resume work
The United States has provided new support of US$2.2 million to UXO Lao, which will enable it to rehire trained technicians it lost in 2014 as a result of funding difficulties.
Mr Phoukhieo Chanthasomboune ( first left ), Mr Benjamin Rhodes ( second left ), US Ambassador to Laos Mr Daniel Clune ( third left ) and officials from UXO and NRA view the exhibition.
The UXO Lao teams will be deployed in Huaphanh, Xiengkhuang, Khammouan, Savannakhet, Salavan, and Champasak provinces, according to a statement from US Deputy National Security Advisor Benjamin Rhodes on 16 October 2015. Mr Rhodes said the United States is committed to helping Laos clear UXO from contaminated areas in order to reduce casualties and to increase the productivity of agricultural land to reduce poverty. Since 1993, the United States has provided over US$83 million in UXO-related assistance to Laos. In 2015, US funding totalled US$15 million. Priority funding will support the clearance of UXO found as a result of evidence-based surveys of contaminated areas. Victims’ assistance programmes will provide direct services to the survivors of UXO accidents and their families and help strengthen the first aid and emergency response of key health facilities and village volunteers in heavily impacted provinces. Funding for risk awareness supports the education of Lao citizens, especially children, about the dangers of UXO. General Director of the National Regulatory Authority, Mr Phoukhieo Chanthasomboun, said 2015 is a turning point for the UXO sector, with approval of the new survey procedures that provide a stronger evidence-based system for surveys, and implementation by all five humanitarian clearance operators. This system helps officials to understand clearly the scope of the UXO problem to better estimate the remaining UXO contamination in Laos. It also gives the sector the ability to plan the time and funding required to reduce or eliminate casualties from UXO accidents, he added. Mr Phoukhieo said the change includes a more systematic village by village approach in line with the new National Socio-Economic Development Plan indicators. “We have moved from a request-based approach to an evidence-based survey approach, including non-technical survey and technical survey, to establish the Confirmed Hazardous Areas (CHAs).”“Firstly, it ensures a better use of the existing resources, by clearing only UXO contaminated land, with a higher number of cluster munitions cleared per hectare. We have already observed the improved results of UXO Lao and other operators due to this new approach,” he added. Secondly, it allows multi-year planning through the allocation of CHAs among clearance operators, in line with the priorities established with local, regional, provincial and national authorities.There are now many defined CHAs waiting to be cleared and, with input from village to national level, a plan to clear these CHAs in the coming years will be developed.“This additional funding to UXO Lao will increase the pace of the survey efforts and more effective clearance; and it will contribute to the full implementation of the new evidence-based concept of operations introduced by UXO Lao at the end of 2014,” Mr Phoukhieo said.
The source is from Vientiane Times newspaper.

domain: economics


text:
If there’s one place where the Internet of Things makes sense, it’s agriculture. From vast fields of soybeans, corn, and a different variety of corn, to the backyard garden, knowing how much sun, and rain crops get can vastly increase yields. For their Hackaday Prize project, [Adam] and [Shane] are building a board designed explicitly for plants. It’s called the SunLeaf, and it has all the sensors and radios a good remote sensing board needs.
The SunLeaf is built around an ARM Cortex M4 microcontroller with an ESP8266 module for WiFi connectivity. Sensors are important for any remote sensing board, and for this the guys are going with SeeedStudio Grove connectors, providing four UARTs, four I2C, and four analog ports.For remote sensing applications, you generally can’t rely on mains power, so SunLeaf includes a port for a solar panel and a battery charger.
Although this project was originally a redesign of [Adam] and [Shane]’s Hackaday Prize entry from last year, what they’ve come up with is a great device for data logging, autonomous control, and environmental sensing for anything, from farms to weather stations.
The [Dallas Personal Robotics Group] recently put together a set of tutorials for their members, including the build process of a table-top robot, they call the Tiny Wanderer. The bot can be constructed pretty easily, and is meant as an introduction to robot building.
The small servo-driven bot uses simple edge sensors to ensure that it doesn’t fall off a raised surface. The sensors were built using a small IR LED and photo transistor, which is partially isolated from the LED by a piece of shrink tubing. An ATiny micro-controller takes two measurements of the amount of IR light entering the photo transistor – one with the LED on, the other with the LED off. The difference of these measurements is compared to determine if the edge sensors are hanging off the side of the table. The logic used here is pretty simple – the difference will be high if the sensors are hovering over a surface, due to reflected light, and low if the sensors are hanging over open space.
The writeup contains templates for building the bot’s structure, as well as source code and schematics for all of the electronic bits.
Be sure to stick around to see a video of the robot in action.
Continue reading “Simple robot knows its bounds”

domain: design


text:
Best-selling in Fiction Books
Save on Fiction Books
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About this product
- DescriptionTHE VERY BEST PERSON TO CATCH YOUR KILLER...IS YOU. In the near future, scientists solve the problem of mortality by learning how to back up and restore a person's memories into a vat-bred clone. When Secret Service agent Ronan Doonan is brutally murdered, he's brought back from the dead one more time to hunt his killer, but this time those who wanted him dead are much closer to home.
- Author BiographyMatt Forbeck has worked full-time on fiction and games since 1989. Frankly, he is a creative machine, and thus utterly perfect for Angry Robot. His many publishers include Adams Media, AEG, Atari, Boom! Studios, Atlas Games, Del Rey, Games Workshop, Green Ronin, High Voltage Studios, Human Head Studios, IDW, Image Comics, Mattel, Pinnacle Entertainment Group, Playmates Toys, Simon & Schuster, Ubisoft, Wizards of the Coast, and WizKids. He has written novels, comic books, short stories, non-fiction (including the acclaimed Marvel Encyclopedia), magazine articles and computer game scripts. He has designed collectible card games, roleplaying games, miniatures and board games. His work has been published in at least a dozen different languages.
- Author(s)Matt Forbeck
- PublisherWatkins Media
- Date of Publication04/11/2010
- SubjectScience Fiction & Fantasy
- Place of PublicationLondon
- Country of PublicationUnited Kingdom
- ImprintAngry Robot
- Out-of-print date04/07/2014
- Width130 mm
- Height198 mm
- Spine26 mm
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domain: literature


text:
Coronavirus Treatment Case Report
“First Case of 2019 Novel Coronavirus in the United States” Holshue et al 2020
Treatment with intravenous remdesivir (a novel nucleotide analogue prodrug in development10,11) was initiated on the evening of day 7, and no adverse events were observed in association with the infusion. Vancomycin was discontinued on the evening of day 7, and cefepime was discontinued on the following day, after serial negative procalcitonin levels and negative nasal PCR testing for methicillin-resistant Staphylococcus aureus.
On hospital day 8 (illness day 12), the patient’s clinical condition improved. Supplemental oxygen was discontinued, and his oxygen saturation values improved to 94 to 96% while he was breathing ambient air. The previous bilateral lower-lobe rales were no longer present. His appetite improved, and he was asymptomatic aside from intermittent dry cough and rhinorrhea. As of January 30, 2020, the patient remains hospitalized. He is afebrile, and all symptoms have resolved with the exception of his cough, which is decreasing in severity.
This suggests that Remdesivir is an effective treatment for Covid 19. I told you so. A guess in Angry Bear March 2 2020 a Case in the New England Journal of Medicine March 5 2020.
Have other patients been given Remdesivir? Have these results been duplicated?
Wonderful for that patient, but one result is still just one result.
I certainly hope that this is being tested more widely. Interesting that a “possible cure” hasn’t been hyped yet, if it is that effective.
Unfortunately, the news may not be so clear:
“Based on our review of the clinical and virological courses, we believe remdesivir’s contribution to efficacy remains unclear, and with a side-effect profile that may not be completely benig”
5 clinical trials currently ongoing. Unclear doesn’t mean unpromising. Completely benign is a very high standard during a pandemic.
I would say generally that saying we should accept millions if deaths because we aren’t sure that a drug is effective and completely benign is well past yhe point where small c conservative becomes large C crazy.
I don’t think there is a case that it is ethical to refrain from giving all Covid 19 positive people who are iver 70 remdesivir.
I would challange anyone to a debate based on reason and moral intuition with no appeal to laws allowed (I know what current law says and also know it us wrong).
The moral principle that one should act in a patient’s interests is not consistent with demanding proof if effectiveness rather than a preponderance of evidence.
The sane moral principle that people have a right to standard of care and, given that, utilitarian calculations are moral does not allow leaving the elderly without remdesivir, because effectiveness can be evakuated with young subjects.
Most deaths from Covid 19 from now on will be negligent homicide.
I believe the 21st Century Cures Act allows them to give a medicine and use the results the same as clinical trial results. So, yes you would be correct.
Take care of yourself also.
I definitely agree that we need to do all that we can and use any resource we can muster. Many are holding out for the hope of a magic bullet such as a vaccine. Unfortunately, such a treatement may be 1-2 years away if ever.
We have to plan as if there will be no cure. Hospitals are already short of supply on protective equipment and the nation stockpiles are dwindling. The point isn’t that we should be defeatist, but that we need to take this seriously. It’s literally a war for survival and the sooner we approach it like that the more people will make it through.
Speaking of drugs.
French Health Minister Olivier Veran:
“The taking of anti-inflammatories (ibuprofen, cortisone …) could be a factor in aggravating the infection. In case of fever, take paracetamol. If you are already taking anti-inflammatory drugs, ask your doctor’s advice,” Veran tweeted.
#COVIDー19 | La prise d’anti-inflammatoires (ibuprofène, cortisone, …) pourrait être un facteur d’aggravation de l’infection. En cas de fièvre, prenez du paracétamol.
Si vous êtes déjà sous anti-inflammatoires ou en cas de doute, demandez conseil à votre médecin.
— Olivier Véran (@olivierveran) March 14, 2020
I think they should let it go through. Eisenhower and Obama ignored the 57 and 09 outbreaks. No worse for wear.
The stock price of Gilead Sciences has risen on news of the testing of the potential treatment:
In other news, Bert Schlitz continues to flat out lie here. I have no idea about Ike and the 1957 issue but Obama did appropriately address the 2009 issue.
Your link is dated March 5. There have been some mixed results from more recent trials:
A previously healthy clinician, now critically ill with COVID-19
Kristina Fiore | Conditions | March 12, 2020
A New Jersey physician assistant who was the state’s first COVID-19 patient is speaking out from his hospital bed, calling his illness “severe” and raising concerns about his treatment.
James Cai, a 32-year-old non-smoker with no other health conditions, has been at Hackensack University Medical Center for about a week and says his illness has worsened significantly over that time. — “In the beginning, they just treat me like normal flu. They say I’m young, I’m not going to die, but they don’t know the truth about corona[virus],”
Cai didn’t respond to MedPage Today’s request for an interview, but he told CBS New York that his illness progressed rapidly. He’s now having trouble breathing and will likely need to be placed on a ventilator soon. – During the interview, Cai appeared at times to be struggling to breathe, and Pulte halted the interview at one point to give him time to catch his breath. — At one point, he said his oxygen saturation dipped below 80%.
… Cai’s request to transfer to Mount Sinai Hospital in New York, where his brother works, and to get into a clinical trial of the antiviral remdesivir, first developed to treat Ebola …
In addition to going to his brother’s hospital, he said he hopes he can start taking remdesivir soon. “I need those two things,” he said. “I don’t know how many days I can last.”
I believe northern Italy’s problem is more dire than most people know which is why Robert is advocating the use of the drug remdesivir now. As it stands, Italy is on the verge of a catastrophic outbreak of the Coronavirus and the country has limited resource to handle the numbers of patients. The country will be forced to go to triage and pick and choose who will die and who will live. Sophie’s choice.
The drug works with N=1. That’s not a lot of statistical power. According to an interview with the doctor involved in Science:
Q: One truism of antivirals for acute diseases is that if you start them late, they don’t work. Do you think that the point at which you gave her the treatment was early enough for it to have worked?
A: I think so. One requirement was that the patient had to have a positive test [showing the presence of SARS-CoV-2] right before starting the drug to make sure that they hadn’t spontaneously already cleared the virus. The day after the infusion of the drug, they consistently got better. I can’t prove it’s related. I wish we had been able to do serial [polymerase chain reaction] PCR testing of their blood, but we couldn’t because of lack of resources. With most investigational drugs tested in, say, macaque monkeys, there’s a nice correlation between the administration of the drug and a drop in the amount of virus in the blood. That’s what we hoped we could have seen in this patient.
[PCR can amplify a tiny amount of viral RNA so that it can be detected and is the basis of most SARS-CoV-2 tests.]
Q: What do you mean by a lack of resources?
A: The county only had 20 coronavirus tests for the whole county. That patient already had a confirmed infection and was not a priority for using them.
He says that they have more tests, including a lab brew version, that they’ll be using on stored samples next week.
OK let’s see. I’m in Rome. Northern Italy is far away (athough we are locked down here too). It isn’t on the verge. They are not enough respirators up there. They have reached the point of true triage — that is deciding there are patients that they can’t even try to save, because they need the respirators for younger patients.
@ Kaleberg, Indeed, the power is low and the size is not 5%. The null that Remdesivir does not work has not been rejected. If one requires proof that it is effective, one should demand that we wait for the results of clinical trials (which are under weigh). I think that is insane. We don’t have to know that it works to decide that, given the balance of evidence, it should be given to patients.
The ideas that the null is that a medicine does not work (fine) and that until this null is statistically rejected we should act as if we assume that it does not work (an insane misuse of the Neyman Pearson framework) combined will cause an increase in the expected value of Covid 19 deaths. One must be abandoned. I would say it is the one which was always an obvious mistake.
On a vaccine. There is a candidate vaccine in people (in Seattle).
There is already (unpublished but they know over there) information on side effects. There will soon be information on whether it is immunogenic. If the initial evidence suggests that it works, then we will have to wait months for the FDA to approve it.
As with Remdesivir, the application of current business as usual policy to a SARS Cv 19 vaccine is insane. It only makes sense if the outcome with business as usual is acceptable.
Given current policy, a vaccine can’t be deployed for 12 to 24 months. Current policy makes no sense in this case. There is no balancing of costs and benefits whatsoever. The rules are the same for this vaccine or a vaccine for a non fatal disease.
@pgl thanks for the link. It doesn’t seem to be very alarming as medical science or biology
Early Results Dampen Outlook for Experimental COVID-19 Treatment
Unofficial early data from the first few COVID-19 patients given an experimental treatment are not what we hoped for.
Mar 14, 2020 at 12:06PM
A potential coronavirus treatment called remdesivir entered a clinical trial in February after positive anecdotal reports from the first patients treated with the experimental antiviral. The company that owns remdesivir, Gilead Sciences (NASDAQ:GILD), hasn’t released any official data from the ongoing study but we recently received an unofficial preview that’s less than encouraging.
A paper describing the first 12 patients with COVID-19 in the U.S. started circulating ahead of an official peer review, and it doesn’t look great for remdesivir. While the paper didn’t have anything negative to say about efficacy, there were some unsettling safety signals.
Coronavirus blood vial
IMAGE SOURCE: GETTY IMAGES.
All three patients treated with remdesivir recovered, but they also reported significant gastrointestinal symptoms. Investigators also noticed elevated liver enzyme levels in their blood samples.
Given the lack of available virus-attacking treatments for COVID-19, some gastrointestinal discomfort isn’t such a big deal, but elevated liver enzymes could nail remdesivir’s coffin shut.
“Nothing tanks an experimental new drug faster than elevated liver enzymes, but concentrations among some patients that weren’t treated with remdesivir peaked higher than those that were.”
The article explains that, given the FDA’s better safe (with just a few tens of millions of deaths) than sorry policy, the fact that, like Covid 19 patients who didn’t take Remdesivir, Covid 19 patients who took Remdesivir had elevated liver enzymes *might* cause the FDA to forbid use of Remdesivir. But it seems to me to have little to do with what the FDA should do.
Thanks for the link. Post updated.
Thanks for the update.
Some enterprising young Italians “Medical company threatens to sue volunteers that 3D-printed valves for life-saving coronavirus treatments” A medical device manufacturer has threatened to sue a group of volunteers in Italy that 3D printed a valve used for life-saving coronavirus treatments. The valve typically costs about $11,000 from the medical device manufacturer, but the volunteers were able to print replicas for about $1 (via Techdirt).


IPD personnel to receive funds for hazardous duty
Three cheers for the Ishpeming City Council, City Manager Craig Cugini and city Police Chief Steve Snowaert for doing the administrative work necessary to get a nice hazardous pay stipend for the city’s police department for its work during the pandemic.
The council met last week and approved $12,000 in payments to 11 police officers and one dispatcher, a Mining Journal story on the matter detailed.
The city’s volunteer fire department did not put in for the funds as the fire chief did not feel the department’s activities currently met the criteria of the CARES Act, which is where the money originates.
Under the program, law enforcement officers, firefighters, emergency medical technicians, 911 operators, local units of government, corrections officers, airport public safety officers and eligible personnel associated with ambulance operations are eligible if they meet certain guidelines.
We suspect the amount of money at issue — $1,000 per person — isn’t going to make or break anyone. That said, simply recognizing the work IPD officers have done and continue to do during these troubling times can only be described as a very good thing.
We hope other area departments also put in for the funds and in doing so, recognize appropriate personnel.


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Jealous, harried air traffic controller Max Fiedler, recently dumped by his girlfriend, comes into contact with nuclear waste and is granted the power of telekinesis, which he uses not only to win her back, but to gain a little revenge.
The US needs to convince the visiting emir Khala'ad of Othar to allow an American military base in his strategic realm. Clueless nightclub waitress Sunny Ann Davis accidentally spots and ... See full summary »
When a professional couple who have lived & worked together for many years finally decide to marry, their sudden betrothal causes many unexpectedly funny and awkward difficulties. They soon... See full summary »
The escaped delinquent John W. Burns, Jr. replaces Dr. Maitlin on a radio show, saying he's the psychiatrist Lawrence Baird. His tactless radio show is a hit, and he becomes very popular. ... See full summary »
Writer Nick Gardenia is kidnapped from his California cliffhouse and forced to rob a bank. Now a fugitive, he seeks help from his ex, Glenda. She is a public defender remarried to a prosecutor, and we get a houseful of hijinks. Written by
Five of the sets constructed on the Burbank sound stage were a bedroom, a garage exterior with staircase to the small apartment where Nick (Chevy Chase) hides, the garage apartment itself, Ira (Charles Grodin)'s offices, and a courtroom, which had real oak paneling. See more »
When Aurora brings the dogs into the final courtroom scene. See more »
This movie is absolutely hilarious! I first saw it a couple of years ago and had my belly aching from laughing by the time it was over. Yesterday it was shown again on TV and it had exactly the same effect on me throughout this second viewing. Playwright Neil Simon, who scripted this film had a real grasp on his prose all through the 70s and 80s, and this film is a delight for everyone familiar with his style of lining up one-liners in such a way that the viewer barely has time to breathe from laughter. All three leads are great. This is real evidence for all those who have doubts about Goldie Hawn's talents, since she is delightful from start to finish and once again proves that she was and still is one of the greatest comediennes Hollywood ever produced. A comedy classic of sorts.
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domain: entertainment


Siwertell unloader overhaul reduces Panamax bulker discharge from 12 days to three
Cargotec continues to deliver MacGregor cranes fit for Arctic conditions
19 August 2009Cargotec has secured an order for six of its MacGregor knuckle-jib crane units from STX Europe
The cranes are specifically designed to operate in severe climatic conditions and extreme air temperatures and will be installed on three icebreaker tugs, designed by Aker Arctic Technology Inc. The units are scheduled for delivery throughout the period between June 2010 and January 2011.
For downloading high resolution image, please click here
For further information please contact,
Cargotec improves the efficiency of cargo flows by offering solutions for the loading and unloading of goods on land and at sea wherever cargo is on the move. Cargotec main daughter brands for cargo handling Hiab, Kalmar and MacGregor are global market leaders in their fields. Cargotec global network offers extensive services that ensure the continuous, reliable and sustainable performance of equipment. Cargotec sales totalled EUR 3.4 billion in 2008 and it employs approximately 11,000 people. Cargotec class B shares are quoted on the NASDAQ OMX Helsinki. www.cargotec.com


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In Room Three: the Eating Parlour on the front ground floor, infancy is awakened by enlightenment, and – as in adolescence – opinions are formed and sides taken. The room consists of bold contrasts; back or forth – even the colours complement the ‘clink-clank’ of the primitive brass clock: black or white, green or white, blue or white, red or white. Like Baroque politics in the wake of the Civil War: Catholic or Protestant, ‘Whig’ or ‘Tory’ – ‘King George or King James’, Man or Nature, Man . . . or Woman – no peace: black or white – nothing between.
Denis Servers, ‘Notes to 18 Folgate Street’, Spitalfields, London.
A rich cultural inheritance written on mobile psychic foundations is a mainstay of the art of Paul Rooney and Susan Philipsz. For both artists, space is not objectively physical, but subjective, psychological, projected. Geography is unstable, subject to memory and narrative. Spaces are gendered, scented, poetically nuanced, never merely empty. Topographies are hybrid, informed by music, art, folklore, fiction, geography, history and philosophy. Both produce work comparable to comprehensive critiques of the environment based on re-articulations of spatial and temporal meaning found in postmodern critical social theory, anthropology and geography explored by figures such as Marc Augé, Anthony Vidler, Doreen Massey and Edward Soja. These critiques draw attention to the ways in which environments are engendered, empowered and contested by subtle and palpable means, building on earlier ambient texts such as Maurice Merleau-Ponty’s The Phenomenology of Perception (1945), Otto Friedrich Bollnow’s Mensch und Raum (1963), Gaston Bachelard’s The Poetics of Space (1969), Robert Harbison’s Eccentric Spaces (1977) and Jacques Attali’s Noise: the Political Economy of Music (1977). Having said this, it should be obvious that neither Rooney nor Philipsz can be said simply to illustrate theory, or produce academic art. They weave adventures and narratives around spaces, leaving us feeling that there could be no other way of responding to the environments that they animate. Their brooding art is a contemporary adaptation of aestheticism; denying the innocent eye by becoming the place it describes. Like the late great Dennis Servers, their focus is squarely on the pleasures of the imagination, on seeing and sensing with historical licence.
Rooney’s Let me Take You There (2003) is a vocal guide to be listened to while standing in a field in Calderdale, Yorkshire. A black and white photograph of this unremarkable snowy field featured on the twelve-inch cover for Joy Division’s Atmosphere (1980), designed by Peter Saville. The single was released shortly after the suicide of Ian Curtis, the group’s lead singer; its funereal imperium thought to exploit Curtis’ untimely demise. As the use of minimal Roman lapidary font suggests, Saville was in fact going through a neo-classical phase. Inspired by the postmodern antics of architects such as Philip Johnston, this style was applied rigorously to the majority of his work in this period. Nevertheless, the myths of dark creative genius continue to haunt both the sleeve and the band. Rather than simply dispel these Chinese whispers, Rooney embellishes them, acknowledging that all forms of knowledge include their own history of mistakes. Adopting the non de plume Alain Chamois and the tone of an avid fanzine writer, Rooney produces a reading of the field that inscribes it within a wider field of cultural meanings.
Rooney combines the discourses of the municipal museum audio guide and romantic rockumentary geography to create a hybrid reading of the Yorkshire landscape. On the one hand, the guide has an educational role, yet it clearly functions as a veiled critique of a society in which the ruins of the industrial revolution, aristocratic privilege, Paul McCartney’s semi, and the studios of contemporary artists all form part of the tourist trail. As regions fight it out for inward investment and Sunday cash, neo-liberal concepts of ‘heritage’ and ‘education’ are seen as having real financial benefits. Since the collapse of heavy industry, cultural tourism had been used as a plaster to over over Northern England’s social and economic woes. Cities such as Liverpool and Manchester have made great capital from their association with popular music. Saville’s work can be found in museums, notably the CIS Manchester Gallery in Manchester Art Gallery, where, alongside Lowry and the Happy Mondays, it is displayed as an example of Mancunian creativity. His work is currently touring from London’s Design Museum to Dundee Contemporary Arts and Manchester’s Urbis, before heading off around the rest of the globe.
Today, such cultural baggage is used to spearhead gentrification programmes such as the Hacienda Apartments in Manchester’s Deansgate (the sales slogan quips ‘Now the Party’s Over, It’s Time to Come Home). Pop escapism is the North of England’s carrot. Rooney filmed Something Happening: After The Human League (2003) from a window in the Bradford and Bingley bank in the High Street, Sheffield, the former entrance to The Crazy Daisy club, the very spot where the extraordinarily ordinary girls Jo and Susanne of The Human League were ‘discovered’ by Phil Oakey. The cultural autonomy of the Northern England is tied to such entrepreneurial and nostalgic readings of its pop culture. The myth has always been that pop will allow talented working class kids to escape from the drudgery of working for the bank (somehow Cilla Black slipped through the net). Erstwhile Hacienda DJ Dave Haslam goes so far to suggest that the economic regeneration of Manchester will emerge only from its creatives, from labour practices and economies fashioned by DJs and designers working in the Northern Quarter around Oldham Street. This imaginary has even been adopted by the Labour Party, who advocate the adoption of sweat equity popularised in the fashion, music and art industries as a model for multi-tasked labour in contemporary Britain:
This sector, the argument runs, provides Britain with the possibility of re-invigorating a distinctive national economy of pop music, fashion and the arts by drawing on both indigenous and migrant traditions of popular culture which have gained currency since the early 1960s. In a talent-led economy, the individual alone is to blame if the next script, film, book or show is not up to scratch. Or as Anthony Giddens puts it (Modernity and Self Identity, 1991), individuals must now ‘be’ their own structures.
Faced with the corporatisation of the remaining vestiges of public cultural space, many contemporary artists are bearing within, returning to the old house of their youth in an attempt to surpass annexation. History and psychology cannot fully determine such space since it is constantly re-articulated and subjectified. In this sense, the political economy of Susan Philipsz’ work lies parallel to the spaces occupied by Rooney’s.
Joy Division were a band that I used to lock myself in my room to for hours as a young teenager. They subsequently became a source of inspiration for my work in later years. I am interested in how sound can be a trigger for memory and the mental space you enter while alone. I try to evoke solitude in my work.
Philipsz’ work establishes space as an introspective, private zone, hermetically sealed from the threshold of the adult world; a territory demarcated by adolescent narcissism and moody existential teenage angst. Philipsz’ mines her subjective teenage recollections, excavating a spatial imaginary of her formative bedroom years from sounds that resemble passages from old records. Using a carillon, she produces a “crystal ring of chimes, like the aural equivalent of frosted branches suddenly shifted by a gust of wind,” an echo of Martin Hannet’s closing sound effects on Joy Division’s Atmosphere. Philipsz attempts to de-familiarise by re-creating these sounds on her own terms, stripping them of their established aural context. The performative aspect of the original recordings is lost, but the memories of the imaginary spaces they suggest remain for most (thirtysomething) audiences. Songs Sung in the First Person on Themes of Longing, Sympathy and Release plays on a loop Isolation by Joy Division, Hang On, by Teenage Fan Club, How Much I Lied by Grand Parsons, Please Please, Please Let me get What I Want by The Smiths. The egocentric space of this pop narcissism is not negated or transcended. As a part of the cultural industry tied to historicity and power, pop fails to provide the authentic experiences it covets.
I would love to go
Back to the old house
But I never will
I never will …
I never will …
I never will …
Since the time and space demarcated by such records is non linear, the personal problems they evoke without resolution; they represent a world without catharsis. The past is pictured as a ruin or a folly to play in, a haunted house to explore, one open to new possibilities and exchanges.

domain: artistic


Samsung launches all-singing, all-dancing model movie
The epic new spot, created by Wieden + Kennedy Amsterdam, strikes a new tone for the phone brand, mixing quirky scenes with a heavy musical theatre vibe
Samsung has channelled Andrew Lloyd Webber for its latest commercial, with the new ad featuring a manifesto of sorts on what you can get from your phone via the medium of song and dance.
The ad is soundtracked by a song titled I’m Open to That, and contains an array of kooky visuals, from a man stepping out of a bear suit to a kitten puking rainbows, to illustrate the often bizarre worlds that are contained in our mobiles.
The spot takes a leaf out of the Apple advertising playbook, featuring plenty of product placement throughout, in charming fashion. Whereas Apple tends to focus on one aspect of its phones at a time though – most typically its cameras – Samsung’s ad goes all in on covering what its products offer us, referencing everything from podcasts to privacy along the way.
The result is an ad that is certainly more out-there and fun than Samsung’s previous advertising offerings, though anyone who struggles to enjoy musical theatre, beware.
Agency: Wieden + Kennedy Amsterdam
ECDs: Eric Quennoy, Mark Bernath
Creative Directors: Zeynep Orbay, Mohamed Diaa
Art Director: Sandra Nicolas
Production Company: Iconoclast
Creative Inspiration Advertising


Professional studio headphones.
The K271 MKIIs are professional over-ear headphones for studio and live use. They combine the comfort of an over-the-ear design and the benefits of closed-back technology for best possible sound reproduction. The sealed design ensures low signal bleeding into microphones in the studio and maximum isolation for live mixing applications.
The K271 MKIIs feature a switch in the headband that mutes the audio just as soon as the headphones are taken off. They provide a professional mini XLR connector for quick replacement of the cable. The package includes a 3m (10ft) straight and 5m (16ft) coiled cable.
• Driver Type: Dynamic
• Impedance @ 1kHz: 55 ohms
• Sensitivity: 104 dB SPL/V
• Isolation: -10dB ~ -14dB
• Connector Type: 3.5mm (1/8")
• Cable Length: 10 ft. (3m)
• Cable Style: Coiled and Straight Left-Side
• Weight: 8.5 oz. w/o cord
• Manufacturer Warranty: 2 year
What's In The Box:
• 1pr leatherette earpads
• 3 m detachable straight cable
• 5 m detachable coiled cable
• 1/8" to 1/4" screw-on adapter


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Arlington County Waives Loan Payments For Affordable Housing Borrowers
A new grant from the federal government will help Arlington County provide rental assistance, and the county is also taking new steps to provide relief for borrowers of affordable housing loans.
Among the beneficiaries of the grant will be residents who need assistance paying their monthly rent, the board said. It will also provide broadband internet access for public school students in need, support food banks, buy personal protective equipment for healthcare workers and establish COVID-19 testing sites.
"This welcome and much-needed grant from the federal government will help us provide the emergency food and housing assistance that those in our community who have lost their livelihoods to the pandemic so desperately need," Arlington County Board Chair Libby Garvey said in a release.
In another move to help the housing market, the Arlington County Board Saturday approved a measure to allow borrowers using the county's affordable housing loan program to waive their 2020 loan payments if they use the money to address rent losses caused by the coronavirus pandemic.
"For many low- and moderate-income renters in Arlington, this is a time of terrifying uncertainty," Garvey said. "This waiver will help our affordable housing landlords help their tenants by eliminating late-payment fees and agreeing not to evict their tenants who can't pay rent through the end of this year."

domain: finance


Stretch Film Machine, Stretch Film Machine Suppliers
1500mm three layer STRETCH FILM MANUFACTURING MACHINE. Shanghai Tailian Plastic Machinery Manufacturing Co., Ltd. US $70000-75000 / Set.;Uline stocks a huge selection of Stretch Wrap, Stretch Film and Pallet Wrap. Order by 6 pm for same day shipping. Over 30,000 products in stock. 11 Locations across ;Police believe the alleged assault of a man at a Queensland timber mill may be linked to bikie gangs. A man suffered serious head and facial injuries and als;Our full line of stretch films is available in machine and hand-applied formats. These formats provide an efficient and cost-effective solution for primary packaging ;Uline stocks a wide selection of Uline Cast Clear. Order by 6 pm for same day shipping. Over 31000 products in stock. 11 Locations across USA, Canada and ;Product 1 10 of 10Discounted machine stretch film rolls! Clear, Colored, and specialty machine stretch wrap. All skids of machine pallet wrap ship free.
Stratasys hails 3D printing breakthrough
New machine handles wider range of materials and will be used for making prototypes;Stretch machine film superior load retention pallet after pallet. Our machine shrink wrap rolls designed for superior load retention stretch film.;Machine stretch wrap film 50 inch x 5000 feet 80 gauge is a hi-performance LLDPE wide web film that performs well on all types of product loads and ideal for ; A £355,000 loan from Barclays has enabled Stockport-based Windmill Tapes to acquire a new advanced, digital label press.


Forecasters: La Niña Is Here, May Last Through WinterGovernment weather forecasters say La Niña is here.
Forecasters: Temperatures Unusually Cool For September, But It Won't LastIf the weather seems unusually cool for September, you aren’t alone – temperatures are indeed down a few degrees for August and the beginning of September.
Record-Breaking Heat Headed For Southern California This WeekendEnjoy the June gloom while you can – temperatures are headed up this week, with triple-digits expected this weekend.
Gusty Winds, High Temperatures Prompt Rare February Red Flag WarningA mixture of strong Santa Ana winds, low humidity and high temperatures prompted a red flag warning for much of Southern California Monday.
Southern California Fall Heat Wave To Cool SlowlyForecasters can see an end to Southern California's October swelter, but the heat and humidity will not go away quickly.
Rain Lingers Over Southern California, High Temps Forecast For Later This WeekLingering rains from a weekend storm are still soaking parts of Southern California, and could for much of the day.
Summer-Like Heat Persists For Southern CaliforniaThe National Weather Service says a high-pressure system will push temperatures into the 90s in many areas beginning Friday.
Southern California Temperatures Begin Cool DownSouthern California’s heat wave will start to dissipate Friday, but forecasters say high surf will continue to pound the coast, generating dangerous rip currents and sneaker waves.
Josh Rubenstein's Weather Forecast (June 29)The Southland will continue to see more of that sticky summer weather from the weekend.
Josh Rubenstein's Weather Forecast (June 15)Get ready for a sizzling start to the work week.
Josh Rubenstein's Weather Forecast (May 19)Look for mostly sunny skies and just a degree or two increase Tuesday.
Cold Late-Season Storm Brings Second Round Of Rain, Snow To The SouthlandA cold late-season storm continued to bring rain and snow to the Southland Friday.
Josh Rubenstein's Weather Forecast (May 15)Round two of the system appears to be dropping south limiting rainfall totals Friday.
Josh Rubenstein's Weather Forecast (May 14)The late season storm is upon us, and it looks like this will be a nice hit for this late in the season.
Cold, Windy Storm Headed For Southern California Expected To Produce RainAn unseasonably cold storm expected to generate strong winds is headed for Southern California Wednesday, with rain expected beginning Thursday afternoon and possibly lasting until Friday night.


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The fine imposed on the individuals are to be paid jointly or severally.
The regulator had conducted an investigation into the scrip of Pyramid Saimira Theatre Ltd (PSTL ) during the period from June to December 2008.
During the probe, it was found that as per media reports published in December 2008, the regulator had directed one of the promoters of PSTL, P S Saminathan, to make an open offer for an additional 20 per cent stake at a price of at least Rs 250.
Media reports led to an increase in the share price of PSTL on December 22, 2008.
However, PSTL informed exchanges that it had not received any communication from Sebi regarding the media reports on open offer.
The next day Saminathan told exchanges that he had received an alleged letter from the regulator. Thereafter, Sebi, through a press release, clarified that no such letter was issued by it.
Sebi had also lodged an FIR in this regard.
Later, it was revealed that forgery was done to manipulate the stock price of the firm and that Nirmal Kotecha, one of the promoters and the then largest shareholder, was one of the major beneficiaries of the manipulation and appeared to have masterminded the forgery.
Pending investigation, Sebi had issued an interim order in April 2009 directing 257 entities and their proprietors/ partners/ directors who prima facie appeared to have played a role in the forgery of the Sebi’s letter not to deal in the securities market till further directions.
It was further observed that several entities directly and indirectly related to Kotecha had bought and sold the shares on exchanges and entered into circular trades, synchronised trades, reversal trades and self trades, among themselves to manipulate the shares of PSTL.
The individuals were the part of entities who were involved in the manipulation in the scrip of PSTL.
While issuing the directions, the watchdog also noted that in March 2018, it had directed the noticees (individuals) to disgorge the profit amount of Rs 22.69 lakh along with 12 per cent interest per annum from December 22, 2008 onwards.
Further, Sebi said the direction in the nature of debarment and the disgorgement that has already been passed against the noticees herein as a relevant factor in deciding the quantum of penalty.
“The matter pertains to the year 2008 and I have considered the time taken for concluding the present proceedings as a mitigating factor,” Sebi’s Adjudicating officer Vijayant Kumar Verma said while imposing the fine.
According to another order passed on Tuesday, the watchdog imposed a fine of Rs 7.63 lakh on Hemant Patel for indulging in insider trading in the shares of KLG Capital Services Ltd.
It was observed that an entity — Awaita Properties Pvt Ltd (APPL) — had acquired shares of KLG through market transactions that led to an increase in the shareholding of APPL in KLG.
Thereafter, APPL made a public announcement on March 3, 2008, to acquire another 20 per cent shares of KLG.
Sebi observed that the information pertaining to acquisition of KLG by APPL was Unpublished Price Sensitive Information (UPSI) till February 28, 2008.
Patel, who was the Whole Time Director of KLG, had access to the said UPSI by virtue of his position connection and interaction with the promoters of KLG, the merchant banker and broker of APPL at the relevant point, the regulator noted.
Patel had traded for himself and also on behalf of Hemant Patel HUF in the shares of KLG while in possession of the UPSI and also passed on UPSI to other persons who executed trades on the basis of such UPSI, thereby, violating the insider trading norms.
In a separate order, the regulator imposed a fine of Rs 2.5 lakh on ACML Capital Markets for misusing clients’ funds, among other violations.
Separately, Sebi on Tuesday slapped a fine of Rs 2 lakh on Ozone Projects Pvt Ltd for making delayed disclosures regarding the financial results of the company for year ended March 31, 2019.
(Only the headline and picture of this report may have been reworked by the Business Standard staff; the rest of the content is auto-generated from a syndicated feed.)


text:
So what’s more shocking: The Zin Diva is drinking wine from a box OR that the 3 liter box of wine retails for $30?
Well, both facts are true. I’m on a work trip for three months in Florida living in dorms with minimal cooking facilities, a low per diem food rate, and few friends (yet) to share my wine with. So rather than see a bottle go bad after drinking a couples of glasses on a work night, I “splurged” on the ultimate wine preservation system: quality wine in a box.
Hah, you say. Quality wine in a box–you’ve got to be kidding! But in this case, I’m not. I’m drinking a Sangiovese blend from Italy that I found at my local wine shop, Rick’s, in Alexandria, VA. While certainly not a splurge wine, this wine is tasty and its longevity once opened is remarkable. At $30 for 3 liters, this works out to $7.50/bottle, quite a deal for a pretty decent wine.
With wine in a box, the wine is contained in a plastic bag inside the box and doesn’t have contact with oxygen. As wine is dispensed, the vacuum within the bag is maintained protecting the wine from the air. This lack of oxygen preserves the wine, allowing it to stay in good condition at room temperature for extended periods after opening.
Here’s a quick wine note to accompany this Conte Ferdinando Guicciardini Red Wine from Toscana I.G.P that clocks in at 13.5% ABV and is imported by Michael R. Downey Selections. Red cherry, dried cranberry, baked strawberry, bright acidity, gray rock, potting soil, soft and approachable tannins with bright fruit on the finish. Pair with a long day at work; freshly grilled chicken, pork, or steak; or Italian food featuring tomatoes or a tomato sauce.

domain: food


text:
Henderson Ponders His Pain
Wednesday, November 7, 2007
Erin Henderson knew immediately the back injury he suffered against North Carolina felt terrible. But only yesterday did the Terrapins inside linebacker realize how gruesome the injury really was.
"That looks pretty disgusting," Henderson said after seeing a photo of himself in the university's student newspaper. "I knew it was bad, but it was a good picture of that. I'm going to frame that one."
Indeed, the photograph shows Henderson, with his knees on the ground, lunging at North Carolina running back Johnny White. But when Henderson's face mask got caught in White's thigh pads, the force of the running back's forward motion forced Henderson's back to bend unnaturally, making his body appear much like an archer's bow.
"I was afraid he broke his back," Maryland Coach Ralph Friedgen said.
Henderson returned and finished the game. He said yesterday he intends to play this week. But Friedgen said Henderson's status for Saturday's game against No. 8 Boston College is undecided.
"I understand that my team needs me out there, and I want to be there for my teammates as well," said Henderson, who underwent X-rays, which came back negative.
Henderson said he returned against North Carolina with the help of back plaster, which served as a brace for his back, and a muscle-stimulating machine, which helped to keep his back muscles loose.
"They created a back for me, basically," Henderson said.
But when Henderson awoke Sunday morning, his back had stiffened so much he couldn't get out of bed for his typical routine of going to his sister's house to watch their older brother, E.J., play for the Minnesota Vikings on television.
Henderson's malady is the latest in an injury-plagued season. Henderson missed a game against Georgia Tech because of a knee injury. He also has played through a broken thumb and an eye ailment.
Friedgen said Henderson did not participate in the team's walk-through Monday. The linebacker did not practice yesterday either, spending some of the session standing next to Friedgen in a black non-contact jersey.
"You can't really do anything," said Henderson, who leads the Terrapins in tackles (99) and tackles for losses (8 1/2 ). "It's tough. I'm having trouble sitting down, getting up, walking. I haven't even thought of running or doing anything like that."


“Rondo” from Incidental Suite is the third movement of this suite originally scored for concert band. This work is rhythmically engaging from beginning to end as the percussion establish the rhythmic motives that move and transform throughout. This flexible arrangement allows ensembles to perform the work with as few as thirteen musicians providing accessibility and flexibility for numerous instrumentation needs, while still allowing a full ensemble sound.
*The posted recording is based on the full band scoring but aligns with the suggested preferences for either woodwinds/strings or brass suggested in the score.
|Oversized, spiral-bound score


text:
Griffin announced via its Facebook page that its collaboration with Crayola, ColorStudio HD for iPad, is now available. We first heard of it just before CES, when news of the app along with the new iMarker stylus came out. The US$29.99 marker-styled accessory allows kids -- or any other coloring ...
Guess what just popped up to the top of our "must-see at CES" list? Chances are, if you're an iPad owner with small kids, you too will be enthralled by the promise and the premise of Crayola's collaboration with peripheral maker Griffin Technologies: ColorStudio HD for iPad, including the Crayola ...
Deals of the Daymore deals
Software Updatesmore updates
- Agile Partners releases Lick of the Day 2.0
- Microsoft Office for Mac 2011 Update 14.3.4
- Pixelmator 2.2 available with over 100 new features and improvements
- DabKick for iPhone lets you share photos, watch videos and now listen to music in real-time
- Google Now added to search app on iPhone, iPad
- GateGuru for iPhone has been updated and greatly improved
Featured Storiesmore stories
I'm never leaving home without my pogo connect again. Love this thing.


text:
Dr. David NABARRO
Former Special Adviser to the United Nations; Professor, Institute of Global Health Innovation, Imperial College London
Dr Nabarro is a medical doctor, international civil servant and diplomat, who served as Special Adviser to the United Nations Secretary-General on the 2030 Agenda for Sustainable Development and Climate Change. He also led the UN's response to the cholera epidemic in Haiti and previously served as the Special Envoy on Ebola. In September 2016, Dr Nabarro was nominated by the UK to stand for the post of Director-General of the World Health Organization (WHO). Dr Nabarro has been appointed as Professor within Imperial’s Institute of Global Health Innovation (IGHI) in 2018.

domain: medical


Each type of light, from radio waves to gamma-rays, reveals something unique about the universe and its electromagnetic spectrum. Some wavelengths are best for studying black holes; others reveal newborn stars and planets; while others illuminate the earliest years of cosmic history. NASA has many telescopes “working the wavelengths” up and down the electromagnetic spectrum. Gamma rays are the highest-energy form of light known to us.
The Fermi Gamma-Ray Telescope orbiting Earth, has just crossed a new electromagnetic frontier and is picking up energetic photons. Scientists from NASA’s Goddard Space Flight Center have been able to produce the first all-sky map of the very high energy universe near the very edge of the electromagnetic spectrum, ranging between 10 billion and 100 billion electron volts. The light we see with human eyes consists of photons with energies in the range 2 to 3 electron volts. The gamma-rays Fermi detects are billions of times more energetic, from 20 million to more than 300 billion electron volts. These gamma-ray photons are so energetic, they cannot be guided by the mirrors and lenses found in ordinary telescopes.
About a third of the new sources can’t be clearly linked to any of the known types of objects that produce gamma rays. For now, scientists have no idea what they are. One of the mysteries is giant bubble structures emanating from the Milky Way’s center and spanning some 20,000 light years above and below the galactic plane. And there are blazars – super massive black holes; the seething remnants of supernova explosions and pulsars – rapidly rotating neutron stars.
Fermi scans the entire sky every three hours, and as the mission continues and our exposure deepens, scientists can see the extreme universe in progressively greater detail. Now that the first sky map is complete, Fermi is working on another, more sensitive and detailed survey. In the next few years, Fermi should reveal something new about all of these phenomena, what makes them tick, and why they generate such ‘unearthly’ levels of energy. But for now, though, there are more unknowns than knowns about this new world.
Fermi Space Telescope: Exploring the Extreme Universe
Fermi is a powerful space observatory that will open a wide window on the universe. Gamma rays are the highest-energy form of light, and the gamma-ray sky is spectacularly different from the one we perceive with our own eyes. With a huge leap in all key capabilities, Fermi data will enable scientists to answer persistent questions across a broad range of topics, including supermassive black-hole systems, pulsars, the origin of cosmic rays, and searches for signals of new physics. The mission’s main instrument, the Large Area Telescope (LAT), is making pioneering observations of gamma-ray bursts at higher energies than ever before from space. Another instrument onboard, the Fermi Gamma-Ray Burst Monitor, is monitoring gamma-ray bursts at lower energies. The combination of the GBM and the LAT provides a powerful tool for studying GRBs over a very wide range of energies.
The mission is an astrophysics and particle physics partnership, developed by NASA in collaboration with the U.S. Department of Energy, along with important contributions from academic institutions and partners in France, Germany, Italy, Japan, Sweden, and the United States.
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What does the Supreme Court’s decision on the Affordable Care Act really mean? In Comment this week, Jeffrey Toobin has some thoughts:
What will Roberts’s opinion on the Commerce Clause question mean for the future of American government? And why did he decide to side with the liberals at all? Read the full Comment, and share your thoughts below.
Illustration by Tom Bachtell.


text: This book is both for those who are seasoned Christians and also for new believers who want a deeper understanding and insight into how the system of the heavenly kingdom operates. I believe this book will shift your thinking and cultivate you to see things as God sees them; you won't see yourself as you once did and neither will you see God as you did before. It is the Lord's will that all His children be equipped with His knowledge, so that they can rise, with the empowerment of the Holy Spirit, above every circumstance that tries to shift their divine purpose. Within this book, you will find a deeper insight into your purpose and role in carrying out God's mandate here on Earth. I pray that by the time you finish reading this book that the Holy Spirit will shift your mindset and cause you to be a soul-winner and a God influencer throughout this Earth. Let the God DNA in you arise, and let every fleshly nature die for the advancement of God's kingdom on the Earth. May God enlighten your understanding and increase your spiritual capacity as you read this book.

domain: library


Easy to install, but the stock resonator isn't restrictive in any way which makes this basically useless. The pipe goes straight through with little holes perforated in the side, but the air isnt diverted by any means.
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Category:MINI Performance Parts Posted:05-20-2015 09:15 AM Views: 62501
Synopsis: Quality carbon fiber and leather or suede shift knob
Wow, this shift knob is sweet! It is a bit expensive, but after seeing the John Cooper Shift Knob and feeling the heft and
quality I was sold. It's one of the only 'aftermarket' shift knobs
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Also fits the Alta SS Kit, BM, Cravenspeed Short Shift kit.


by Jay Nolan
The Knox County Hospital saves lives. That’s why this newspaper has been such a strong advocate for the hospital. Even though we report both good and bad news about the hospital, its finances, activities and staff, overall we believe Knox County is definitely better off with a hospital than without one.
In fact, 48% of heath care provided in our state comes from rural hospitals, according to state commissioner of agriculture and candidate for governor, James Comer. Clearly rural hospitals play a huge role in protecting and preserving the health and welfare of our citizens.
But, our local hospital, like many others across the state, also faces a huge financial challenge. That’s partly due to another statistic Comer cited when he visited the Advocate offices recently. The commissioner stated, “Twenty-five percent of the state is on Medicaid now.”
Because Medicaid is a federal program that often reimburses the local hospital far less than the actual cost for many services, rural hospitals provide these services at a loss.
Making things even worse, hospital administrator Ray Canady tells me more than 70-75% of the patients treated from Knox and from surrounding counties are Medicaid or Medicare patients. No business can succeed if it loses money on three out of every four of its customers! A small rural hospital like ours is no exception.
What is the answer?
I believe one answer is for our hospital to have more customers that can pay the full cost.
And, that’s why I say racing at “Thunder Gap” could help our hospital. How?
Keeneland recently announced they are committed to investing $30 million to build their new facility and bringing hundreds of new jobs to this county. Jobs with benefits will provide hundreds more people access to good insurance. This private insurance pays much more of our hospital’s cost.
So, lets all hope Keeneland’s project is hugely successful. Their success will help many local people, local businesses, and expand our local tax base. So indirectly, yes, I do think those horses could help our hospital.
What do you think?


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A slightly softer touch for equities so far
- Eurostoxx -0.4%
- Germany DAX -0.4%
- France CAC 40 -0.4%
- UK FTSE -0.5%
- Spain IBEX -0.5%
We’ve been through this many a time already, whereby Europe opens on a slightly more tepid and subdued note only for things to turn around later in US trading.
US futures are keeping more mixed with tech leading the way again, as both S&P 500 futures and Dow futures are down 0.2% while Nasdaq futures are up 0.1%.
European indices are arguably just showing some signs of moderation, with the DAX just coming off fresh all-time highs.
The bond market is still a key spot to watch in terms of overall risk sentiment and so far, Treasury yields are steady with 10-year yields flattish around 1.40%.


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Five Cool Water Slides at Walt Disney World Resort, water and snow I'm guessing, nice mix
COOL Water Park Slide, St Joseph Mo
Happy Magic Water Cube, Beijing | 31 Ridiculously Cool Water Parks To Visit With Your Kids
16 of the most awesome Water Slides You have to try
rainbow water slide
Water slide! how cool would this be if this was in your house and lead to your pool once you slid down it?! The slide also goes through an aquarium! Too cool!
White Water - Kalani Towers - Branson, Missouri
Ever considered adding a pool slide to your swimming pool at home? Today, we will be showing you a couple of designs that famous pool makers and contractors have thought of adding to the swimming pool their clients asked them…
Cool water slide with a loop!
Cool pools and water slides its like a pool version of chutes and ladders!!:) lol I rode on number 19

domain: travel


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Hope for Peace in South Sudan
How can the faith community in South Sudan be a catalyst for peace?
Bishop Isaiah Dau, the presiding Bishop of the Pentecostal Church of South Sudan, shares his story.
Surviving over five decades of war, Bishop Isaiah Dau remains committed to striving toward peace in South Sudan. His story sheds light on the positive impact that faith communities are making toward peace. As a Network, we are continuing to develope sustainable channels of communication between the international community and religious actors such as Bishop Dau.
The interview with Bishop Dau was conducted on May 23, 2017 in New York.

domain: sociology


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The cohesin complex is involved in multiple aspects of genome organization. These include gene transcription, DNA repair and sister chromatid cohesion; the tethering of sister chromatids to enable their proper distribution in mitosis. Several rare developmental disorders, termed ‘cohesinopathies’ are characterized by impaired cohesin functioning. In addition, cohesin components are frequently mutated in cancer and loss of sister chromatid cohesion can be detected in many cancer cell lines, upon activation of oncogenes in normal cells and by genetic or pharmacological perturbation of DNA replication.
The cohesion team studies fundamental cohesion biology and investigates how deregulation of cohesin functions affect cell fate and disease etiology. We address these questions by using a wide range of genetic, biochemistry, microscopy and cell biology approaches. This will increase our understanding of the diverse activities of cohesion and may provide clinical opportunities if specific vulnerabilities of cancer cells with defective cohesion can be identified and targeted.
Van Schie JJM, de Lint K, Molenaar TM, Moronta Gines M, Balk JA, Rooimans MA, Roohollahi K, Pai GM, Borghuis L, Ramadhin AR, Corazza F, Dorsman JC, Wendt KS, Wolthuis RMF, De Lange J (2023). CRISPR screens in sister chromatid cohesion defective cells reveal PAXIP1-PAGR1 as regulator of chromatin association of cohesin. Nucleic Acids Res. 2023 Sep 13:gkad756.
Van Schie JJM, de Lint K, Pai GM, Rooimans MA, Wolthuis RMF, De Lange J (2022). MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC. Life Sci Alliance; 6(2): e202201596
Carvalhal S, Bader I, Rooimans M.A., Oostra A.B., Balk J.A., Feichtinger R.G., Beichler C., Speicher M.R., van Hagen J.M., Waisfisz Q., van Haelst M., Bruijn M., Tavares A., Mayr J.A., Wolthuis R.M.F., Oliveira R.A., De Lange J (2022). Biallelic BUB1 mutations cause microcephaly, developmental delay and variable effects on cohesion and chromosome segregation. Science Advances ;8(3):eabk0114
Van Schie, J.J., Faramarz, A., Balk, J.A., Stewart, G.S., Cantelli, E., Oostra, A.B., Rooimans, M.A., Parish, J.L., de Almeida Estéves, C., Dumic, K., Barisic, I., Diderich, K.E.M., van Slegtenhorst, M.A., Mahtab, M., Pisani, F.M., te Riele, H., Ameziane, N., Wolthuis, R.M.F., De Lange, J. (2020). Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion. Nat. Comm. 11:1-18
Benedict, B., van Schie, J.J.M., Oostra, A.B., Balk, J.A., Wolthuis, R.M.F., te Riele, H., De Lange, J. (2020) WAPL-dependent repair of damaged DNA replication forks underlies oncogene-induced loss of sister chromatid cohesion. Dev. Cell 52:683-698.
De Lange, J., Faramarz, A., Oostra, A.B., De Menezes, R.X., van der Meulen, I.H., Rooimans, M.A., Rockx, D.A., Brakenhoff, R.H., van Beusechem, V.W., King, R.W., Wolthuis, R.M.F. (2015). Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function. Nat. Comm. 6:1-12


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Acme::MetaSyntactic::ben_and_jerry - Ben & Jerry's Ice Cream Flavours
Flavours of the Ben & Jerry's ice-cream brand.
The official Ben & Jerry's website is at http://www.benjerry.com/.
Abigail, Philippe Bruhat (BooK).
The package doesn't list retired flavours. The Ben & Jerry website hides the retired flavours in a hideous flash application.
2012-08-13 - v1.000
Made updatable from a source URL, updated with the list of flavors for August 2012, and published in Acme-MetaSyntactic-Themes version 1.014.
Submitted by Abigail.


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Bench PartnersBench Partners Video SeriesElectrophoresis/Western Blotting VideoTips and Techniques VideoVideos
Want a streamlined, easy workflow for hand casting polyacrylamide gels? This tutorial video shows how to use Bio-Rad’s new FastCast™ acrylamide kits to hand cast gels, saving time while providing the benefits of the latest precast gel chemistries.
Research led by Prof. Ryan Jensen at Yale Medical School focuses on elucidating the links between BRCA gene mutations and breast cancer. Learn how researchers in his lab use Bio-Rad’s V3 Western Workflow to study interactions between BRCA proteins and the DNA repair protein RAD51. Understanding how these proteins interact in carcinogenesis and tumor growth will provide a new understanding of breast cancer mechanisms that could lead to new therapies.
Learn how scientists in the Gene Regulation Laboratory at the Korea Advanced Institute of Science and Technology (KAIST) use the ChemiDoc MP imaging system in their work investigating the molecular machinery involved in epigenetic gene regulation.
Learn how scientists in the Department of Animal Physiology at the University of Erlangen in Erlangen, Germany use the ChemiDoc MP imaging system in their work investigating sensory systems, in particular, the eye.
The nine PDQuest tutorials are chapterized so you can focus on what you want to learn. Each video runs from 3 to 9 minutes and features callout boxes that highlight important information to complement the audio explanations.
Bio-Rad’s five-step western blotting workflow incorporates traditional blotting techniques with innovative technology, allowing quick confirmation of gel runs and blot transfers, and simplifying protein normalization. See how it works.
Scientists from UCSD, UCD, The Salk Institute, and the University of Alabama talk about the speed, performance, and quality of electrophoresis runs using the Mini-PROTEAN TGX gels in their labs.
Bio-Rad’s PROTEAN i12 IEF system is specially designed for running different sample types, different gradients, and multiple 2-D electrophoresis protocols at the same time. Watch the video to learn about all the new features of this IEF system.
Harvard Medical School Postdoctoral student Sririam Kosuri explains how the Gel Doc EZ system has changed the way researchers image gels in the George Church lab at Harvard Medical School’s Wyss Institute.


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A Shtinky Little Combo
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The only thing better than one great holiday gift is two! Spread some good-smelling holiday cheer with Patrick McDonnell's A Shtinky Little Christmas gift book, SIGNED COPY! At just 5"x5" it's the perfect stocking stuffer keepsake. AND grab a cozy blanket to curl up and read by candlelight from our soy Blue Spruce candle. Each is made in the USA and hand-poured into 8 oz. glass jelly jars and topped with a gold metal screw-on lid.


The 3005Y Bella + Canvas - Youth Short Sleeve V-Neck Jersey Tee is 4.2 ounces and 100% combed ringspun cotton. With a youth unisex fit this v-neck makes ordering easy. Sideseamed construction and 30 singles for durability and comfort. Dark Grey Heather is 52% combed and ringspun cotton, 48% polyester.
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Youth sizes: S(6/8), M(10/12), L(14/16)