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In early January I had the pleasure of heading down to sunny California to work on a few projects with The Mom’s View… a vertical of Maker Studios.
I shot an episode of The Mom’s View Talk Show… where the gals and I talked about the pregnancy and post-pregnancy body. You can view that show here.
But I also worked on a couple of DIY videos as part of The Mom’s View DIY Challenge! The first one is out now – personalized tea towels! I bet you are not surprised what I stamped on them…
So…. what do you think? Thumbs up or thumbs down?
I love them and think they would make a pretty thoughtful gift… wedding, housewarming, hostess gift…
Or simply a little something for your own kitchen to add a pop of color and touch of personality.
Now, I’m going to keep it real… shooting this was my first experience with a teleprompter. So, if I seem a little stiff in the video it’s because apparently some of my personality hides behind my hair (or somewhere) when I read from a teleprompter.
But here’s to new experiences! And I think it is just a matter of time before the teleprompter and I become dear, dear friends… I just know it. I just hope I get more chances.
Practice makes perfect…
But… personalized tea towels.
I think I need to bring that craft home. What do you think?


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My office assistant Alex is proof that if you hang around a DIYer, you become a DIYer. After taking many of the photographs for my blog projects, she has begun swapping her camera for a brush and a can of stain. This past week she announced that she was going to build, stain, and finish a pine headboard for her house. And she came up with a new twist I hadn’t thought of…
Alex arrived with a plan and her 1″x6″ horizontal slats and her 2″x4″ upright supports pre-cut according to her plan at the home improvement store, so she quickly cleared off the workbench and started her assembly.
Remembering my mantra that glue is always stronger than nails, she squirted a bead of glue where the first slat would be attached to the first upright.
She then nailed the horizontal slat to the upright. Alex purposely picked nails with heads for the rustic look she wanted.
Within minutes she had each slat measured and marked for even spacing, then glued and nailed in place.
A quick sanding with #150-grit sandpaper rounded the edges and smoothed out the boards.
Alex then brushed on a liberal coat of Minwax® Pre-Stain Wood Conditioner to reduce the blotchiness that occurs when staining softwoods like pine.
While the Wood Conditioner was drying, Alex explained that she wanted to use two different colors of Minwax® Wood Finish™ to get a weathered barn board effect: Provincial for the brown base coat, followed by Classic Gray for an aged look. Since this was a new combination for both of us, I suggested she use the back of one of her boards to experiment with the two stains.
Once satisfied, Alex applied Provincial to the bare boards, let it soak in for about five minutes, then wiped off the excess stain.
After letting the Provincial stain dry, she next brushed on a coat of Classic Gray, let it sit for about five minutes, then wiped off the excess. (The board at the top has had both layers of stain applied and the excess wiped off.)
After the stain had dried, Alex finished her headboard with the first of two coats of Minwax® Clear Brushing Lacquer, a fast-drying protective finish.
Once home, she attached the two sections to the wall with an L-bracket, and topped it with a shelf running the length of the headboard, getting both a headboard and a display space out of the same project! And making me very proud!
Until next time,
Thanks for stopping by!

domain: hobby


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The National Broadcasting Commission has banned a number of new music videos from being broadcast anywhere in the country.
Artistes whose works are affected by the action include Psquare, Wande Coal, Timaya, Flavour, D’Prince, Goldie, Chuddy K and Tillaman.
The videos were banned for containing erotic lyrics and scenes, promoting nudity and for showcasing what the NBC describes as suggestive dance steps.
The offending videos, according to the commission, are listed as Psquare’s Alingo, Wande Coal’s Go low, Timaya’s Bum bum, Flavour’s Shake and D’Prince’s Take banana.
Goldie’s Ski bobo and Chuddy K’s Brazilian Hair came under NBC’s axe for featuring minors and exposing them to indecent dance steps. Tillaman’s Koma Roll was not exempted.
A spokesman for Psquare, Bayo Adetu, has described the ban as an unnecessary and unjustifiable action.
As a major regulatory body, the NBC keeps close watch on the contents of music videos and audio CDs broadcast by Nigerian television and radio stations.
In the past, the body had cause to officially kick out Afrobeat musician, Femi Kuti’s wave-making song Bang Bang Bang and Konga’s Baby konga from the air space. Quite recently, the commission had to flex its muscles when DJ Zeez’s Body Language fell short of its expectations.
In a release by the NBC, the videos classified as ‘not to be broadcast in whole or in part’, were banned for different reasons. The videos include and the reasons are as follows:
1. Tillaman ft. Vector- Koma Roll (contains erotic and suggestive dance steps)
2. Wande Coal- Go Low (scenes of nudity in the video)
3. D’Prince - Take Banana (contains erotic, vulgar words and suggestive dance styles)
4. Flavour- Shake (vulgar and suggestive dance steps)
5. Goldie- Ski Bobo (featuring a minor with suggestive and immoral dance steps)
6. Chuddy K- Brazilian Hair (features children and ladies with suggestive and erotic dance steps)
7. Timaya- Shake your Bum bum (erotic and suggestive dance steps with vulgar lyrics)
8. Psquare- Alingo (erotic scenes at the end of the musical videos)

domain: entertainment


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Exterior is appealing and the images online are very misleading. Hotel was damp and had a smell to it. Our room was leaking water from above, so we had to move rooms. Very inconvenient. Interrupted our stay. Breakfast was average...no hot food. Pool was indoors...More
Thank Jamie T
Response from Super8boone, Front Office Manager at Super 8 Boone NCResponded 18 April 2017
Dear guest, Thank you for choosing Super 8 as your destination in Boone. I do apologize about the inconveniences you experienced during your stay. I will speak to the staff to make sure that these things do not happen, again. I hope that you choose...More
My husband and I have stayed in Boone a few times over the last couple months and most have been spent at the Super8. We've even brought our Aussie a few times. The staff is great and the rooms are really clean. The free breakfast...More
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This business uses tools provided by TripAdvisor (or one of its official Review Collection Partners) to encourage and collect guest reviews, including this one.
Response from Super8boone, Front Office Manager at Super 8 Boone NCResponded 12 April 2017
Thank you for providing feedback on your stay with us and we are delighted to see that you enjoyed your stay with us! We are glad to hear that you experienced exceptional service from our staff. We are also glad to hear that our breakfast...More
This was my first time spending the night at a Super 8. After reading the reviews I booked my room for the night. The breakfast was good. I love coffee their coffee was excellent. The staff are friendly and the room and bathroom are clean....More
Thank Nancy M
Response from Super8boone, Front Office Manager at Super 8 Boone NCResponded 5 April 2017
Thank you for providing feedback on your stay with us and we are delighted to see that you enjoyed your stay with us! We are glad to hear that our breakfast, coffee and rooms meet your expectations. We are also glad to hear that you...More
US$61 - US$176 (Based on Average Rates for a Standard Room)
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TripAdvisor is proud to partner with Expedia, Hotels.com, Travelocity, Booking.com, Priceline, Cancelon, Hotwire and HotelsforEveryone so you can book your Super 8 Boone NC reservations with confidence. We help millions of travellers each month to find the perfect hotel for both holiday and business trips, always with the best discounts and special offers.

domain: travel


The Brookline Asian American Family Network (BAAFN) wishes to invite the community to the virtual Asian American Student Essay Contest Award Ceremony next week.
The event will take place on Wednesday, May 11, 2022, from 06:09 p.m. to – 07:00 p.m. o n Zoom.
To RSVP, please visit here.
Registrants will be sent the Zoom link.
Each year in recognition of Asian American and Pacific Islander Heritage Month, BAAFN holds an essay contest to allow students to freely express “what it means to be an Asian American.”
This year BAAFN received a record 28 submissions, which were reviewed by a panel of judges.
Many essays explored students’ experience with anti-Asian rhetoric and violence in the U.S., which have been exacerbated by the CoViD-19 pandemic being linked inconclusively to China.
At the ceremony, awards will be presented to the following contestants:
- BAAFN Award: Eun-Jae M. Norris and Emerson Lin;
- Content Award: Ellie Hyde;
- Creativity Award: Kayla Chen;
- Honorable Mentions: Linsey Brookfield, Tina Cheng and Stephanie Wong.
Attendees will have the chance to hear the essays read by the students themselves.
The event also will feature the premiere of “Being Asian American at BHS,” a video documentary created by Brookline High School seniors Sam Lee and Jean Hur.
“I commend every contestant for speaking up, putting their experiences to paper, and shining light on this difficult subject. Together, their voices created a symphony against the erasure, invisibility, and racism that the Asian community has historically experienced,” BAAFN Steering Committee Member Hsiu-Lan Chang said.
BAAFN thanks the Committee of Judges — Christian Angelos, Giselle Ferro Puigbo, John Hodgman, Caitlin Starr, and Charu Swamy — who read the submissions. The judges of Asian descent expressed that they experienced similar hardships growing up.
“These 28 essays were often difficult to read. Difficult, only because of the pain and honesty that was so well conveyed on the page. I was able to find hope and promise for the future when looking at the 28 entries as a whole,” Judge Angelos said. “It brings me so much joy to know that 28 students have that knowledge and the awareness to tell their stories with so much honesty and insight. I walk away from this experience feeling encouraged that this courageous generation of Asian Americans feels emboldened to tell their stories, and that they will not be silenced.”
BAAFN also wishes to thank the following community sponsors for their generosity and support of this initiative: Jay Lebed and Boston Portfolio Advisers, The Brookline Booksmith, The Brookline Community Foundation, Brookline Frames, Sheri Flagler from Coldwell Banker Real Estate, John Hodgman, Jin’s Fine Asian Cuisine, Pho Viet’s, Karyn Wang, and The Town of Brookline Office of Diversity, Inclusion, and Community Relations.


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Kuyper and Poverty: The Christian Solution [...]
"Authority and Sovereignty" Abraham Kuyper presents a system that rejects popular sovereignty. His solution is called, "sphere sovereignty." This system is a worldview that stands on the foundation of theism. It can, therefore, be considered a living conservatism that transforms our hearts and our homes.

domain: library


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Full Size (highres_width x highres_height)
Solutions above were created using soft and feminine curves to appeal to the target audience. Transparent and printed PVC was used to create the affect of shower imagery. Graphics complement the packaging and feel of the products along with furthering the shower feel. Responsible for the conceptualization and structural design.
Favorited by 16 people
More Projects From Chad Buske

domain: artistic


Everton striker James Vaughan has avoided bone or ligament damage after receiving treatment for a severed artery sustained during a 1-1 draw with Bolton.
Vaughan was accidentally caught on the left leg by Bolton defender Abdoulaye Meite in a challenge on the edge of the area just after the hour of the game at the Reebok Stadium.
But following a series of x-rays that confirmed no other problems, Vaughan was released, with instruction to keep his leg elevated.
It was obvious Vaughan was in considerable pain at the time, while the horrified reaction of team-mate Andy Johnson after witnessing the injury increased the anxiety surrounding the 18-year-old.
Vaughan, who had scored Everton’s equaliser in the 33rd minute to cancel out Kevin Davies’ opener 15 minutes earlier, was taken off on a stretcher.
He was immediately treated by club doctor Ian Irving, before being transferred to the nearby Beaumont Hospital where he was further assessed.
“Obviously, we are delighted it’s not a break or anything like that,” said manager David Moyes immediately after the game.
“Knowing him, he will probably want to play next week because he is a tough lad.”
Commending Vaughan on his performance, Moyes added: “He was terrific.
“It’s as if he has that freshness back, that youthfulness after not playing for most of the season.”


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A great idea for doing something fun with the kids at home that does not involve spending a lot of money and eating junk food, is to cook up a storm in your kitchens in Perth.
There are some great recipes that you and your kids can create in your kitchen together.
This is a fun way of teaching them how to cook in the kitchen without using a microwave oven.
Pizza is always an easy one for them to start with and then of course nachos and salads.
These popular dishes are easy and are a good way to help them learn about healthy food options.
Pizza cooked using a flatbread base, fresh tomatoes, capsicum, red onion, fresh parsley and basil leaves is delicious and healthy.
When making nachos, plain unsalted corn chips are best. Using warm refried beans mixed with some flavourful salsa is a great base to stand the corn chips into. Sprinkle with some grated cheese before baking for a few minutes to melt the cheese.
Served with a dob of natural yoghurt and some shredded lettuce, diced fresh tomatoes and red onion slices. Yummo and still a healthy option.
The salads can be an exciting time for the kids in the kitchen at home.
You can place lots of fresh veggies, fruit and nuts on your kitchen work bench, and then let them go for it. They may surprise you with some of their menu ideas. They may choose to move away from the old lettuce, tomato and cucumber salads and present you with a wonderfully exotic culinary delight.
Little chefs in your kitchen having a fun time while learning valuable skills is always a winner.
It makes sense to have a kitchen design at home that is family friendly. A family friendly kitchen design will make it a breeze to have fun in the kitchen with the kids.
The main requirement is that you have a large enough work area or kitchen bench top. If you do not have a large bench top you may need to use the kitchen table.
If you need to make a few changes to your current kitchen design at home, a simple kitchen renovation is easier than you think.
With a large work area you and your children can stand comfortably and prepare their dishes.
Having plenty of room to move about makes everything so much easier and safer.
We don’t want anyone tripping over while carrying their dishes.
If the design of your kitchen is dated and cramped it could be time for a kitchen renovation.
There is no better time than now. Talk to the experts and get some advice on how to create a family friendly functional kitchen.
Flexi Kitchens in Perth are the people to call. They have been designing and installing custom made furniture for WA homes since the turn of the century.
Speak to one of our team today and find out how easy it is to have a brand new kitchen that is perfect for you and your little chefs.
Call Flexi Kitchens us now on (08) 9301 4200.

domain: food


Black Hills State University will co-host the 2009 conference of the Midwest Writing Center Association (MWCA) in Rapid City next week.
Black Hills State University has been awarded a $499,844 grant by the National Science Foundation to study plants of this region and neighboring states.
Black Hills State University faculty are transforming lives and making headlines with their achievements.
The Black Hills State University concert band will be teaming up with musicians from Rapid City Oct. 17 and 18 to play benefit concerts for Honor Flight South Dakota.
Kent Meyers, Black Hills State University associate professor and writer-in-residence, has just published his fifth book, Twisted Tree, and it is receiving excellent reviews.
Black Hills State University will be presenting Blood, a dark comedy written by a student, Jessica Juhrend, speech communications major from Spearfish.
Black Hills State University is celebrating the Year of Science by showcasing the beauty of science in an art exhibit in the David B. Miller Student Union Ruddell Gallery Sept. 30 through Oct. 23. Artwork by Kelly Collins, communication arts graduate from Rapid City.
Black Hills State University recently hosted the 13th Annual Alumni Art Show in the Ruddell Gallery.
Black Hills State University invites community members to attend a variety of lectures and presentations planned for the fall 2009 semester.
The 44th annual Western Literature Association (WLA) Conference will be held in Spearfish Sept. 30-Oct. 3 with Black Hills State University as the host university. The conference is expected to draw more than 300 attendees from across the country.
High school students and community members are invited to attend the 2009 Art Fair at Black Hills State University. The Art Fair will be held Thursday, Oct. 1 from 8 a.m. – 2 p.m. in the David B. Miller Student Union Jacket Legacy Room.
Black Hills State University art graduate Dustin Price will have his artwork, A Discourse in Stillness: The Language of Silence on exhibit at the Apex Gallery on the campus of South Dakota School of Mines and Technology Sept. 28 through Nov. 6. Price will give an artist’s talk Monday, Sept. 28 during the reception from 5-7 p.m.
Phil Braun, senior theatre and mass communication from Gregory, and Kayla Schuring, senior elementary education major from Groton, were named the 2009 Swarm Day king and queen at Black Hills State University last night.
The Black Hills State University music department will host a faculty recital Sunday, Oct. 4 at 2:30 p.m. in the Clare and Josef Meier Recital Hall on the BHSU campus.
Anything is Possible at Black Hills State University! Faculty, staff, and students are making headlines with their achievements. See what BHSU is in the news for lately. Call 605.642.6215 to share your news item.
Black Hills State University
Office of Admissions
1200 University Street
Spearfish, SD 57799-9502
Black Hills State University, 1200 University St., Spearfish, SD 57799, (800) 255-2478 | © 2014
Tuesday, May 23, 2017


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2kg Fillet of Beef
2tbs English Mustard
500g Puff Pastry
500g Parma Ham
4 Sprigs of Thyme
100ml White Wine
1 egg for egg wash
- Dice the mushrooms and Sauté in a pan. Add the thyme and wine and continue to sauté until the wine has been absorbed.
- Season the Beef with salt and pepper and seal in a hot pan on all sides.
- Place the Beef in a preheated oven at 180c for 15-20mins and then cool.
- Lay out the Parma ham on a large sheet of cling film and spread with the mustard then place the cool fillet of beef on top and roll up tightly. Refrigerate for 2 hours.
- Roll out the puff pastry to the thickness of a one pound coin. Cut in to one rectangular piece and one square piece. Place the fillet of beef on top of the rectangular piece of puff pastry and place the square piece of puff pastry on top of the fillet of beef. Join the seams around the bottom by crimping the pastry.
- With the back of a knife mark with a criss cross pattern over the top of the Wellington but be careful not to cut through the pastry.
- Brush with the egg wash and bake in the oven at 180c for 22-26min.
- Remove from the oven and rest for 20mins before serving.
This recipe was created by Smallpiece Catering, based in Southampton.
Head Chef, Ann Smallpiece, established Smallpiece Catering in 2010. After working for over 30 years in the catering industry, Ann wanted to create a unique experience and service for clients, which took their thoughts and ideas and turned them into a seamless reality. In 2012, Ann’s daughter, Gemma joined the business, bringing a wealth of experience in sales, marketing and event management.
The family duo create bespoke menus for each and every client whether it’s a wedding feast, fine dining dinner, corporate event, BBQ, afternoon tea or a simple buffet. They source local food suppliers who provide the finest ingredients, to complement their menus perfectly.
Find out more about the producers of the local ingredients used in this recipe:


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ROANOKE TANGO VIOLINISTS
If you’ve never danced along to “Gipsy Tango” or “La Cumparsita,” then you’re missing out! Book a Tango Violinist to play these songs and other classics live at your special event. Grab a partner and search below from the top-rated musicians in the Roanoke, VA area.
Please note these Tango Violinists will also travel to Vinton, Hollins College, Cave Spring, Cloverdale, Salem, Boones Mill, Daleville, Troutville, Blue Ridge, Goodview, Bent Mountain, Hardy, Catawba, Lafayette, Elliston, Fincastle, Thaxton, Copper Hill, Villamont, New Castle, Callaway, Montvale, Wirtz, Rocky Mount, Moneta, Redwood, Glade Hill, Shawsville, Check, Lithia


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Allen Dorfman, who died in a hail of bullets in Chicago, was a financier for the Teamsters Union, a union with a long history of links to organized crime.
Dorfman, sentenced to spend the rest of his life in prison for trying to bribe a senator, was shot Thursday in a snow-speckled hotel parking lot.
The bushy-browed insurance man, linked to the crime syndicate for four decades, most likely died on the orders of underworld associates to 'shut him up,' law enforcement officials said.
Dorfman and four others, including Teamsters President Roy L. Williams and reputed mobster Joseph 'Joey the Clown' Lombardo, were convicted last year of conspiracy to bribe former Sen. Howard Cannon of Nevada.
The legal problems of Williams and other leaders of the International Brotherhood of Teamsters, Chauffeurs, Wharehousemen and Helpers of America can be traced to the 1930s, when Congress began regulating the trucking industry.
The mysterious killing of Teamster President Jimmy Hoffa in 1975 was not the first Teamster link with the mob, but was perhaps the most sensational.
Hoffa left his lakeside home in Detroit that summer for lunch at a fashionable suburban restaurant and was never seen again, disappearing so completely that a $1 million search has turned up only thousands of phony tips and two skeletons -- neither of them Hoffa's.
A federally protected witness told Congress last year that Hoffa tried to kill his teamsters successor, Frank Fitzsimmons, and east coast trucking boss Tony Provenzano when he got out of prison, but his adopted son, Chuckie O'Brien, revealed the plot and Hoffa himself was murdered.
Charles Allen, a nephew of one-time gangster Charles 'Blinky' Palermo and himself a Mafia associate, said Hoffa enlisted him to shoot Fitzsimmons in the parking lot of Teamsters headquarters in the shadow of the U.S. Capitol. But Provenzano and new Jersey mobster Salvatore 'Sally Bugs' Briguglio had Hoffa 'ground up in little pieces, shipped to Florida and thrown into the swamp, ' Allen said.
The names in Allen's testimony comprise a rogues' gallery of crime. Hoffa's 13-year sentence for mail fraud and jury tampering was commuted by President Nixon in 1971. Provenzano died in prison several years ago and Briguglio was killed in a gangland-style execution. Fitzsimmons died of cancer in 1981.
The Teamster's problems continued with the efforts to deregulate the industry, begun by President Carter in 1977. The decision caused a great uproar within the union.
Prosecutors in the Dorfman case said he and the others offered Cannon a choice piece of Las Vegas land at a bargain price in return for Cannon's agreement to scuttle deregulation legislation. Cannon did not buy the land, the legislation was passed, and the senator was not implicated in the conspiracy.

domain: news


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Omicron bus rule confusion as clubs seek clarity
Last updated on .From the section Scottish
Clarity is being sought amid confusion over travel protocols for Scottish clubs due to the Covid Omicron variant.
The Scottish FA and SPFL Joint Response Group (JRG) told clubs all people on a bus must self-isolate for 10 days if one tests positive for the new strain.
Some teams then altered their travel arrangements as a result.
However, Scotland's national clinical director Prof Jason Leitch said on Saturday people can test and release if double vaccinated.
The document sent by the JRG, which has been seen by BBC Scotland, stated "clubs must risk assess their own travel arrangements considering this information [about everyone on a bus needing to self-isolate]" and that the rule had been confirmed by the Scottish government.
But speaking on BBC Scotland's Off The Ball, Prof Leitch said: "There's rules that the government set, and the rules that each sector sets."
He added: "If you are in charge of the Hearts bus or the St Johnstone bus, you are thinking about trying to increase that distancing again going back to how it used to be.
"But if you don't live in the same household, the government rules are that you can test, isolate until your test is back negative, then go about your business."
Aberdeen took an extra bus to Perth for their victory over St Johnstone, with manager Stephen Glass adding: "It's something we're hoping that there's real clarification on soon because these boys are testing pretty regularly and it would be great to keep the games on, because otherwise I fear if that happens [that everyone on the bus has to isolate] it's going to be difficult.
"It's important there's rules and regulations in place and no grey areas, and I think that's a pretty simple thing to do."
St Johnstone counterpart Callum Davidson added: "We're hoping for clarity on the Covid rules. I can't afford to lose a whole bus of players."
BBC Scotland has contacted the JRG for comment.
Scientists are warning that the UK is facing a substantial wave of Omicron infections in January without further restrictions and Scotland recorded 5,018 new Covid cases on Friday.


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Finding the perfect size tires for your Jeep Wrangler JK can seem difficult, since you don’t want to buy tires that won’t fit, and you don’t get a chance to see if they fit until you’ve bought them. Luckily Jeep JK.com is here to help you in your selection of rubber. We’ll let you know what fits and what won’t, then it’s up to you to decide on the manufacturer and model of tire that you’d like.
The Jeep JK makes it easy to fit larger rubber with a limited amount of lifting. The JK in stock form will easily fit 32″ tires (32 was the largest tire size available from the factory).
0″ of lift will allow you to safely run 32 inch tires. If you’re willing to do some trimming you may be able to make a 33 fit. While a 35 may technically fit, you’ll end up rubbing your tire. Stick with a 32 or smaller when you don’t have a lift.
1″-2.5″ lifts will allow 33″-35″ tires with little or no rubbing.
3″-4″ lifts will accommodate 35″-37″ tires more comfortably, or you could install a 2″ budget boost and 1″ body lift. A wheel backspacing of 4.5″ or less may be needed on 35″ and larger tires to avoid rubbing the frame and other chassis components.
Things to keep in mind when adding bigger tires:
- Your dealership can calibrate your JK’s speedometer up to a 32″ tire. If you have larger than 32″ tires.
- If you’re going to run 12.50 inch wide tires, you’ll want wheels with at around 4.5 inches of backspacing (more than 4.75 inches and the tire will rub the frame, less than 3.75 inchs and the tire will stick out beyond the fender flares.
The best way to decide what tires are for you is to find the look that you’re after, then work backward from that – pricing out the tires, the lift, and deciding if you’ll need to regear or not. Here are some popular Jeep JK tire / lift options:
33 inch tires and no lift:
33 inch tires and 2.5″ lift:
33 inch tire and 3″ lift:
35 inch tires and no lift:
35 inch tires and 1.5″ of lift:
35 inch tires and 2″ of lift:
35 inch tires and 2.5″ of lift:
35 inch tires and 3″ of lift:
35 inch tires with 4.5″ of lift:


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The Speaker of Lagos State House of Assembly, Hon Mudashiru Obasa, has said he is a responsible lawmaker who has nothing to hide.
He was reacting to his invitation by the Economic and Financial Crimes Commission, EFCC on Thursday over allegations of fraud and financial misappropriation.
Obasa in a short statement signed by him said: “The Economic and Financial Crimes Commission invited me today (Thursday). As a responsible citizen and lawmaker, I honoured the invitation. I have nothing to hide. When we are called upon by law-enforcement agents in their investigations, as responsible citizens, it’s our duty to oblige them.”
A Federal High Court in Lagos, had, on Thursday, granted the Economic and Financial Crimes Commission, EFCC, temporary forfeiture of funds linked to Mudashiru Ajayi Obasa, Speaker of the Lagos State House of Assembly.
The EFCC in a motion dated August 12, 2020 and marked FHC/L/CS/1069/2020, asked the court to issue an order directing that the funds in three bank accounts be forfeited in the interim. According to the anti-graft commission, the three bank accounts are “being investigated for the offences of conspiracy, diversion of funds, abuse of office and money laundering.”
While one of the accounts (001852963) is a domiciliary account, the other two (001852956 and 5002349821) are naira current and savings accounts, respectively. After hearing the application filed by S. Sulieman, counsel to the EFCC, the court ruled in favour of the commission on September 15, 2020. Earlier on, Thursday, Wilson Uwujaren, EFCC spokesperson, confirmed that Obasa was at the agency’s office for interrogation.
“He responded to an invite from the commission this morning,” Uwujaren confirmed.
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- We support decision to shutdown churches that flout COVID-19 protocols – Oyo CAN
- COVID-19 lockdown: Over 24,000 children have not returned to school – Sanwo-Olu
- Tambuwal appoints committee to investigate Sokoto central market fire
- Anambra Governorship election to hold November 6 – INEC
- Vice-President Yemi Osinbajo flags off N5,000 cash transfer to low-income earners in urban areas
- Arewa Youth Leader says Northern Nigeria is the most backward region despite having the president
- Borno Governor asks Federal Character Commission for more employment slots
- Buhari appoints Nigeria’s first female ambassador to the United States
- Motorcycle riders are working as spies for kidnappers – Amotekun says
- Where will herdsmen graze if they leave the forest reserves? – Miiyetti Allah queries Akeredolu’s vacation order


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Amazon Renewed Refurbished products with a warranty. Click “Internet Update” giyabyte b. The BIOS will automatically detects memory type and size. Item is in your Cart. GA-8ID Motherboard – 56 Easy Driver Pro free scan will find all the outdated drivers on your PC. Next, Easy Driver Pro searches a database of over 11 million drivers and matches missing, corrupt, or obsolete Drivers to the latest, most compatible drivers for your operating system.
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Pearl Izumi Elite Softshell Jacket - Closeout!Perfectly equipped for cold weather riding, the Pearl Izumi Elite Softshell Jacket has a windproof, waterproof laminate in-between its outer knit face and fleece lining for protection from the elements, warmth and plenty of flexible stretch. New S Café technology improves moisture transfer, temperature regulation and odor-resistance. Semi-form fit allows for room for layering, full zip with draft flap thwarts chilly winds and reflective details throughout keep you visible from every angle.
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text:
The number of wells drilled in Canada is expected to increase by 31 percent next year compared to this year, but weak commodity prices coupled with “abnormal” political and social factors may continue to plague the industry, the Canadian Association of Oilwell Drilling Contractors (CAODC)
Uncertainty over pipeline infrastructure developments and a looming price on carbon will continue to depress Canada’s long-term investment plans, the association said.
Although the number of wells drilled is expected to increase, the rig count is expected to decrease by 55 next year from 665 drilling rigs this year, remaining “near historic lows”, CAODC said. However, the well count is seen to be slightly higher in Saskatchewan, as the province is leading recovery efforts.
“Activity is moving in the right direction, but we’re still in a depressed and desperate economic environment,” CAODC President Mark Scholz said.
Scholz is also calling upon provincial and federal governments to consider the impact of a carbon tax and lack of pipelines on Canada’s investments and jobs in the oil industry.
“In order to achieve a healthy oil and gas industry, governments must ensure its fiscal policies are competitive, predictable, and consider the cumulative costs of doing business in Canada versus other global jurisdictions,” the official says.
For years, Canada’s oil companies have been struggling to build enough
What’s more, some analysts argue that a Trump presidency could be
By Tsvetana Paraskova for Oilprice.com
More Top Reads From Oilprice.com:


|The anchor is made from Grade 5 Carbon Steel, and is Zinc Plated. This anchor is designed for use in Concrete, and should never be used in block or brick base material.
|The anchor is designed for use in a Dry environment. ÕÌ_
|Head Style ÕÌ_
|The anchor is a Hex Washer Serrated head and is designed to allow the head to sit on top of the surface of the item being attached.
|Hole Diameter/Bit Diameter
|The anchor requires a 5/8 hole to be drilled in the base material (Concrete). The hole should be drilled with carbide tipped bit that meets ANSI standards and used in a hammer drill.
|A 13/16" is required for driving the anchor into the base material.
|Diameter of Anchor ÕÌ_
|The diameter of the anchor is 5/8".
|The length of the anchor is 5"
|The length of the threads on the anchor is in length.
|The minimum anchor embedment into the concrete is 2-3/4". Therefore, the anchor must be installed so that a minimum of 2-3/4" of the anchor is embedded into the concrete.
|Maximum Fixture Thickness
|The maximum fixture thickness or the maximum thickness of the material being fastened for a anchor is 1-1/4". This will ensure that the minimum embedment of 2-3/4" will be met.
|Fixture Hole Diameter
|The hole in the fixture or material being fastened must be larger than the designated diameter of the anchor. The 3/4" diameter anchor requires the hole in the fixture to be 3/4'
|Spacing between Anchors
|Each anchor must be spaced a minimum distance of 10" from each other when measured center to center.
|It is very important not to install the anchor any closer than 6" from an unsupported edge of the concrete.
From the Manufacturer
Red Head Large Diameter Tapcon Inch Anchor is a high performance anchor that cuts its own threads into concrete. The anchor bodies are made of hardened carbon steel and zinc plated, Grade 5. The anchors have a finished hex washer head with anti-rotation serrations to prevent anchor back-out, and the head of the anchor is stamped with a length identification code for easy inspection. The anchors should be installed with carbide tipped hammer drill bits made in accordance to ANSI B212.15-1994. Use standard ANSI bits instead of proprietary bits, which will reduce the chances for anchor failure due to incorrect bit usage, and will cut costs. The Large Diameter anchors install in less than half the time of wedge anchors or adhesive anchors, by simply drilling a pilot hole and drive the LDT anchor by hand or impact. They remove easily, no torching or grinding required to remove anchors. The Red Head anchors have a single piece design, no nut and washer to assemble, and more threads for better thread engagement and higher pullout resistance. The Large Diameter Tapcon anchors have closer edge/spacing distance than mechanical anchors, and higher loads in shallow embedments. ÕÌ_
You may return most new, unopened items within 30 days of delivery for a full refund. We'll also pay the return shipping costs if the return is a result of our error (you received an incorrect or defective item, etc.).
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text:
Talk about a winter treat, try growing your own semi dwarf citrus tree(s). Last year, I planted a 15 gallon “Satsuma” seedless mandarin orange and one year later, we are feasting on an amazing harvest of sweet, juicy seedless mandarins. Try using mandarins in salads and dressings, not to mention fresh off the tree anytime!
I found the plant fairly easy to grow, full sun with normal fertilization and decent drainage. I kept the soil pH on the acidic side, the plant did great. I strongly recommend this particular variety because it stays relatively small, easy to maintain, and heavy fruit production.
Late fall / winter maturing citrus is such a special treat to have in Southern California. Just imagine all those mid western and eastern folk never having the opportunity to grow and have fresh citrus like we do!
With many varieties to choose from, you can select a tree that suits the size of your property. A nicely maintained citrus tree can be a very attractive small to mid size tree with the added fruit as a tremendous benefit.

domain: agronomy


IBM's Jeopardy playing supercomputer has been touted by some observers to be one of the biggest computing advancements in the past several deca...
Kicking off its 2011 PartnerWorld Leadership Conference, IBM has announced an expanded set of incentives for business partners offering IBM-based cloud and analytics services.
Hewlett-Packard wants to manage the construction phase of its clients' data center projects, hoping to expand its revenue from this area and, it says, help customers complete projects more quickly and for as much as 30 per cent lower cost.
The U.S. Energy Department's Argonne National Laboratory has commissioned IBM to build what will become one of the world's most powerful supercomputers, IBM announced Tuesday.
Kenneth Olsen, the computer industry pioneer who co-founded and led minicomputer king Digital Equipment Corp. for 35 years, died at the age of 84 on Sunday in Indianapolis.
China is building a city-sized cloud computing and office complex that will include a mega data center, one of the projects fueling that country's double-digit growth in IT spending.
Can cloud-based computing be made more secure in the future using what crypto geeks call "fully homomorphic encryption" to send data as "encrypted blobs" that can be understood and subject to processing without having to actually de-crypt them first ...
The CEOs of IBM and Dell have called on U.S. government leaders to put aside their differences and create a long-term agenda to promote innovation and improve the country's competitive stature in the world.
Oracle has agreed to pay the U.S. government US$46 million to settle complaints that Sun Microsystems, which merged with Oracle in 2010, engaged with other technology vendors in a kickbacks scheme affecting government contracts, the U.S. Department o...
Intel Capital and IBM are investing a combined US$350 million in a new effort by President Barack Obama's administration to encourage entrepreneurs and mentor new businesspeople.
IBM is hoping to bring the concept of Facebook's activity streams to enterprise applications, using a vastly expanded social networking toolkit that the company released Monday.
IBM, Intel and Hewlett-Packard on Monday said they would invest in an effort led by the White House to create jobs and promote growth in emerging technology areas such as cloud computing, health care and mobile applications.
Joining Microsoft, Oracle, Google and others, IBM plans to offer a cloud-based office suite, the company announced on Monday.
IBM's LotusLive on-demand collaboration suite is getting a boost via integration with SugarCRM and Ariba's Discovery Service supplier database, the companies announced Thursday.
IBM and the China-based Range Technology will build a cloud computing data center near Beijing that the companies claim will be Asia's largest by floor space.
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GGG Evaluation Team
First impression on unpacking the Q702 test unit was the solid feel and clean, minimalist styling.
For work use, Microsoft Word and Excel programs pre-installed on the device are adequate for preparing short documents.
The Fujitsu LifeBook UH574 allowed for great mobility without being obnoxiously heavy or clunky. Its twelve hours of battery life did not disappoint.
The screen was particularly good. It is bright and visible from most angles, however heat is an issue, particularly around the Windows button on the front, and on the back where the battery housing is located.
My first impression after unboxing the Q702 is that it is a nice looking unit. Styling is somewhat minimalist but very effective. The tablet part, once detached, has a nice weight, and no buttons or switches are located in awkward or intrusive positions.


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Wednesday, October 1
Lincoln Police department
Lincoln Police investigate suspicious activity
Wednesday Sep 10 2014
At approximately 7:22 a.m. Friday, police officers responded to the area of 6th and P streets for a report of a suspicious male, according to a Lincoln Police Department news re ...
Lincoln Police seeking victims of burglaries, thefts
Tuesday Jul 22 2014
The Lincoln Police Department has recovered various pieces of jewelry, watches, computer parts, cellular phones, stamps and other items. If you are a victim of burglaries or ...
31st annual National Night Out is Aug. 5
Tuesday Jul 22 2014
The Lincoln Police Department invites all Lincoln residents to participate in the 31st annual National Night Out festivities set for Tuesday, Aug. 5. The National Night Out fo ...
Police, fire “doing a wonderful job”
Friday May 09 2014
Carol Feineman’s article in the May 1 Messenger, “More officers needed to battle heroin,” made a big splash across the first page but that is all. According ...
Police need more officers to battle heroin and other drugs
Thursday May 01 2014
While heroin is becoming more prevalent in Lincoln, it is difficult to track the number of users. That’s according to Lincoln Police Chief Rex H. Marks. “But t ...
Take-back day offers free drug disposal
Thursday Apr 24 2014
Foothill residents have 10 locations Saturday to safely dispose of expired and unwanted medication. Lincoln residents don’t have to travel far to take advantage of Satur ...
Start a Neighborhood Watch if you don’t have one near you
Thursday Apr 17 2014
There are 6,783 homes in Sun City (Lincoln Hills). Our Neighborhood Watch can reach nearly every one of these through our email network. This is how we located the owner of the ...
COP group welcomes new volunteers
Thursday Mar 20 2014
Lincoln Hills’ resident Ralph Martinez was checking out local volunteer groups at the city police department this month when he ran into two guys in uniform who signed him up ...
Local resident arrested after fight with officers
Wednesday Mar 05 2014
The Lincoln Police Department announced that a local man was arrested yesterday morning in connection with the investigation of a disturbance in the 4000 block of Benton Drive. On ...
Lincoln Police Secure Arrest in Series of Burglaries
Tuesday Dec 31 2013
The Lincoln Police Department announced Dec. 31 that the investigation into a series of residential burglaries has resulted in the arrest of a Rocklin man and the recovery of prope ...
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domain: law


text:
Logic’s name has grown tremendously since he first stepped on the scene six years ago as a teenager from Gaithersburg, Maryland. With two albums under his belt now, Logic took to Instagram to announce that he has two gold certifications.
His debut LP, 2014’s Under Pressure was officially recognized as selling 500,000 units October 7.
The other award is for half a million units sold of the Suicide Squad single “Sucker For Pain” which he appears on with Lil Wayne, Wiz Khalifa, Imagine Dragons and Ty Dolla $ign.
In the post, Logic thanks his Ratt Pack fans for all of their support through the years.
He is now working on his third album, AfricAryaN, which is to explore biracial identity.
Check out Logic’s post announcing his two gold certifications below.

domain: celebrity


text:
No Females in Heat
Ginger spent the night and seemed fine when we picked her up. Since her stay was short not able to make any comments
She is absolutely amazing! Both of my dogs loved her, and she kept me updated the entire stay! Will be using her every time I have to go out of town!
Took such good care of my babies and will definitely be using her again
Loving and Affordable Dog Sitting!
I have had dogs almost my entire life and have loved all breeds I have encountered. From a 12 pound cheweenie to a 85 pound Doberman. I will always treat your dog as if they were my own and make them feel at home while you’re gone. We can go on walks, hikes, trips to the dog park and I’ll even give your pup a bath. Or we can just relax in the ...
What Gabrielle would like to know about your dog
Are they good with kids? Are they good with other animals? Are they potty trained? Do they have any health issues I need to be aware of like allergies or medications they take? Do they have any not so good behaviors I should look out for?

domain: pet


text:
Comprar Livros online é fácil e confiável, aproveite e compre o livro Physiology Of The Graafian Follicle And Ovulation – Hunter, R. H. F. – ISBN: 0521781981.
The development and selection of ovarian follicles is one of the most active areas of contemporary reproductive research. Relevant experimental work extends from laboratory rodents, across a wide range of domestic species, to human clinical studies, especially as related to problems of fertility and in vitro fertilisation. This volume provides comprehensive coverage of the field, integrating research findings from animal and human studies and condensing the vast published literature into a meaningful and digestible physiological account which highlights the key role played by the oocyte in influencing all stages of follicular development.
Autor: Hunter, R. H. F.

domain: literature


text:
Vile, taunting outbursts aimed at a prosecutor and a victim’s family forced court officers to haul Bampumim Teixeira out of his own trial before the jury found him guilty of murder Tuesday in the vicious 2017 stabbing deaths of two doctors in South Boston.
Court officers dragged Teixeira out of court Tuesday morning during jury deliberations after he lashed out at Assistant District Attorney John Pappas, telling him, “You better hope I don’t get out of jail,” before making a sexually explicit threat.
They removed him a second time just before the verdict was read Tuesday afternoon when he turned to the sobbing families of the victims and blurted out, “You want to know his last words?”
Teixeira, 33, was convicted of first-degree murder in the brutal slayings of Dr. Richard Field and his fiancee Dr. Lina Bolanos inside their Dorchester Avenue apartment on May 5, 2017.
Police found the couple laying in pools of their own blood, their hands tied behind their backs and their throats slashed after Field sent desperate text messages to a friend that a gunman was in their apartment.
By the time police arrived, both had died. Teixeira was still inside the apartment and was shot by police officers.
The jury came back just before 4 p.m. on Tuesday after two days of deliberations and an emotional day in court. Teixeira, a 33-year-old homeless convicted felon and former concierge at the building where he committed the murders, was also found guilty on charges of home invasion, armed robbery and kidnapping.
A Suffolk County judge would not allow Teixeira to return to court after the second outburst, while Suffolk District Attorney Rachael Rollins said her staff was looking at leveling new charges at Teixeira for making threats.
“The grace and dignity that these families showed, I don’t know if I could have done it,” Rollins said after the guilty verdict. “They were silent, they don’t have a voice, and the defendant is able to engage in this outrageous behavior in making allegations and defaming a person he slaughtered.”
Pappas said Teixeira’s comments “just reaffirmed that we have had the right person all along, and he really exposed what his intent was.”
Teixeira had claimed to police detectives that he was having an affair with Bolanos and said Field killed his fiancee when he walked in on them cheating. Teixeira said he killed Field in self-defense — a story Pappas knocked as “utterly absurd and ridiculous” in his closing statement last week.
Pappas said Teixeira used his knowledge of the Macallen building to sneak up to the 11th floor armed with a BB gun and two knives where he waited for the couple to return so he could rob and kill them.
Only weeks before the killing, Teixeira had completed a nine-month sentence for two bank robberies in a plea deal that allowed the native of West Africa to keep his green card and avoid deportation.
Bolanos, 38, was a pediatric anesthesiologist at Massachusetts Eye and Ear; Field, 49, an anesthesiologist at North Shore Pain Management. The couple planned to marry last year.


text:
Korean culture club
Graduate Student, Simon Lee
The Korean Culture Club of Texas State was founded in 2011 by Jay Shin and a group of Korean exchange students, striving to establish an inclusive community where members learn about and celebrate the Korean culture, lifestyle and history. Through dance, cooking and various culturally relevant activities, they seek to expose and educate the community to the rich and fascinating culture found in South Korea.
KCC holds an annual Arirang Festival that celebrates the Korean culture, advertising Korean food, traditional dances, modern Korean Pop dances, booth activities and a market all ran by club members.
The final KCC logo was inspired by the brush strokes designed in the t-shirt design.
The poster design was inspired by a grungy paint brush aesthetic, including elements of the Korean flag, such as the trigrams that surround the Taeguk symbol on the flag. The trigrams were stacked to portray an exclamation point, with the red point designed as a Korean seal that reads " Korean Culture Club" in Hangul.

domain: sociology


text:
Editor’s note: This show aired before officials confirmed the victim’s age in the Lemon Grove shooting.
SAN DIEGO — On this edition of FOX 5 News Now, a deadly shooting in East County and other news you may have missed overnight.
Click on the link for each show topic to see more.
East County shooting: After the show, authorities said the victim in a deadly Lemon Grove shooting has been identified as a 15-year-old boy. The shooting happened just before 2 a.m. near the corner of Palm and Mulder streets in Lemon Grove, according to San Diego County Sheriff’s Department.
Fallen Marines identified: The five Marines killed in an aircraft crash Wednesday near Glamis in Imperial County have been identified. The victims, based at Marine Corps Air Station Camp Pendleton, were all assigned to Marine Medium Tiltrotor Squadron 364, Marine Aircraft Group 39 and 3rd Marine Aircraft Wing.
San Diego weather: The heat is here, and it’s no joke for parts of the county. FOX 5’s Megan Healy takes a look at the big disparity between the coast and areas further inland.
Inflation report: Economists didn’t get the news they were hoping for Friday — inflation sped up, rather than decreasing. Here’s what it means for your wallet.
FOX 5 News Now is San Diego’s only interactive digital newscast. Join your host Matt Meyer each Saturday and Sunday at 10 a.m. for the day’s top headlines. Your questions and comments will shape the show in real time. Watch live with any device on fox5sandiego.com or the FOX 5 app.
FOX 5 News Now is brought to you by San Diego County Credit Union.


text:
A,B and C were partners in a firm having capitals of Rs 60,000 Rs 60,000 and Rs 80,000 respectively. There current account balance were A-10,000 , B-5000 and C-2000 (Dr.).According to the partnership deed the partners were entitled to an intt. on capital @ 5% p.a. C being the working partner was also entitled to a salary of Rs 6,000 p.a. The profits were to be divided as follows:
(i)The first Rs 20,000 in proportion to their capitals.
(ii)next Rs 30,000 in the ratio of 5:3:2.
(iii)remaining profits to be shared equally.
During the year the firm made a profit of Rs 1,56,000 before charging any of the above items. prepare the profit and loss appropriation on A/C.
A and B are in a partnership sharing profits and losses in the ratio of 3:2. on 1st april 2012,they admitted C into partnership.he paid 50000 as his capital but nothing for goodwill which was valued at 40000 for the firm.he acquired 1/5th share in the profits , equally from both partners.it was also decided that......
a) land and building be written off by 20000.
b) stock be written down by 3200.
c) a provision of 1000 be created for doubtful debts.
d) an amount of 1200 included in the sundry creditors be written back as it is no longer payable.
balance sheet is as follows...
land and building
plant and machinery
cash in bank
Prepare the revaluation a/c partners capital a/cs and the balance sheet and pass the journal entries of the new firm.
lata and mamta are partners with capitals of Rs 300000 and Rs 200000 respectively sharing profits as lata 70% and mamta 30% during the year ended 31 march 2005 they earned a profit of Rs 226440 before allowing interest on partner's loan. the terms of partnership are as follows:
1. interest on capital is to be allowed @ 7% p.a
2. lata to get a salary of Rs 2500 per month.
3. interest on mamta's loan account of Rs 80000 for the whole yr.
4. interest on drawings of partner's at 8% per annum . drawings being lata Rs 36000 and mamta Rs 48000.
5. 1/10 of the distributable profit should be transferred to general reserve. prepare the profit and loss appropriation account.
rply me the solution to this ques. in detail.
y and z are partners with capital of rs 25000 and 15000 each partner is entitled to 9% intrest on capital z is entitled to a salary of rs 6000 p.a together with a commision of 6% of net profit remaining after deducting intrest on capitals and salary and after charging his commision the profit for the year before making any of the above adjstment amount to rs 30800 prepare partners capital acc
Give the necessary adjusting journal entry with working notes.
pls give the solution that who the ammunt come
Copyright © 2022 Aakash EduTech Pvt. Ltd. All rights reserved.

domain: finance


text:
Pixley ka Isaka Seme Hospital
Healthcare Facilities Architecture
Client: Department of Health, South Africa
Pixley ka Isaka Seme Hospital is a new 500 bed District level hospital built in the KwaMashu area north of Durban. The hospital boasts a 100 x 50m footprint across 5 levels, and contains operating theaters, intensive care, high care, pharmacy, general wards and an infectious diseases wards.
Photo Credits: Photos courtesy Enza Construction

domain: medical


The Governor has signed a bill that addresses suicide prevention training for educators. By July 1, 2019, school boards are now required to have one hour of nationally recognized training on suicide prevention and post intervention for all licensed school personnel who have contact with students grades K-12.
School boards will also be required to annually have evidence-based, evidence-supported training on the identification of “Adverse Childhood Experience” (ACE) strategies to mitigate toxic stress response. The training is required for all licensed school personnel with regular contact with students in K- 12. The content of the training is required to be based on nationally recognized best practices.
ACE are potentially traumatic events occurring in childhood that can have negative, lasting effects on an individual’s health and well-being. According to the Iowa Department of Public Health, in 2017, there were 433 people in Iowa who died of suicide. Suicide is the second leading cause of death for Iowans ages 15-34. It is hoped that this bill would provide the proper training for educators to recognize the signs of possible suicide and prevent future tragedies.


Redmond, Washington – (The Hosting News) – December 9, 2005 – Computer software developer, Microsoft Corp.
today launched an integrated solution for small-business retailers in the U.S. which combines Microsoft Office Small Business Accounting 2006 with Microsoft Point of Sale or Microsoft Retail Management System.
This free software add-in allows retailers to transfer point-of-sale data, such as transactions and purchase orders, directly into their financial management software. In addition to dramatic time savings and the reduction of manual data entry, the key benefit to small-business retailers is the ability to manage cash flow more effectively, thus helping improve profitability.
According to Guy Gilbert, Group Product Manager for Office at Microsoft, ”Whether managing transactions at a single store or a chain of stores with Microsoft Point of Sale or Microsoft Retail Management System, small-business owners and their accounting professionals now have an even simpler means of assessing their businesses’ financial health in a single view through Microsoft Office Small Business Accounting 2006. This new integration furthers Microsoft’s long-term commitment to meeting the needs of small businesses by fundamentally improving their productivity.”
Smoothly connecting point-of-sale data with back-end accounting systems has been a persistent challenge for many small-business retailers who lack the IT budgets and resources of their larger competitors. Of the approximately 1.34 million U.S. retail companies, an estimated 99 percent have fewer than 10 stores, with 96 percent being single-store retailers, according to IHL Consulting Group Inc.
With the new Microsoft software add-in, small-business retailers can utilize point-of-sale information to run financial reports, helping them manage their businesses more accurately and effectively.
Tracie Hiemstra, owner of Bella Rose Fine Gifts and Furnishings in Seattle explained, ”Microsoft Point of Sale has proved its worth countless times over in terms of saving us significant time and money in ringing up sales, inventory tracking and other processes. Now that we can automatically integrate transactions and vendors into Microsoft Office Small Business Accounting 2006 without having to buy new software or hire an IT specialist, I’m counting on even greater savings that can go straight toward improving our business and growing our bottom line.”
The software add-in was developed with EVT Solutions Inc. (www.evtretail.com), a Microsoft Certified Retail Management System Partner. It can be downloaded at no extra cost from the Microsoft Download Center at www.microsoft.com/businesssolutions/possolutions/accounting .


text:
Visitors of “The Moving Wall,” a half-size replica of the Vietnam Memorial that stands in Washington D.C., search for names of loved ones, friends, and comrades lost on the Vietnam War following the opening ceremony of the wall June 13, 2019 in Medical Lake, Wash. Visitors can view the display 24 hours a day at the 200 block of South Prentis St. in Medical Lake. (U.S. Air National Guard photo by Staff Sgt. Rose M. Lust/Released)
70.0-200.0 mm f/2.8
No camera details available.
This photograph is considered public domain and has been cleared for release.
If you would like to republish please give the photographer appropriate credit.
Further, any commercial or non-commercial use of this photograph or any other
DoD image must be made in compliance with guidance found at
which pertains to intellectual property restrictions (e.g., copyright and
trademark, including the use of official emblems, insignia, names and slogans), warnings
regarding use of images of identifiable personnel, appearance of endorsement, and related matters.

domain: history


text:
Search For "pakistan security"
Updated : 1 month ago IST
The IGP Islamabad directed all officers to be present in their respective areas and briefed the officials regarding the duty.
Updated : 1 month, 1 week ago IST
Karachi Police Office (KPO) -- a centrally located building on the city's main artery -- came under a terrorist attack on Friday by the banned outfit Teheek-e-Taliban Pakistan (TTP).
Updated : 1 month, 2 weeks ago IST
The locals' officials in the region, on Saturday, said that the convoy of security forces and employees of the Marri Petroleum Company was on its way from North Waziristan to Bannu when a rickshaw struck the team. The outlawed Tehreek-i-Taliban Pakistan (TTP) has claimed responsibility for t
According to Levies Constable Jamal Shah, a vehicle unit was out on a routine patrol in the central area of Kohlu when a roadside bomb went off.
Updated : 1 month, 3 weeks ago IST
Senior government officials said that IMF mission chief for Pakistan Nathan Porter has reached in Islamabad to hold technical discussion with authorities.
Updated : 2 months, 1 week ago IST
About half of the total fatalities or deaths caused by terrorist attacks in 2022 in Pakistan were concentrated among personnel of security forces and law enforcement agencies. Another 234 personnel of security and law enforcement agencies were also injured in the reported terrorist attacks.
The top military commander in Pakistan's Balochistan province has said that Gwadar's security would be completely entrusted to the police in the next four months, in the wake of massive protests in the region.
Updated : 2 months, 2 weeks ago IST
It's a double whammy for Pakistan which has a new 'enemy' (Taliban) on its western border and a new nightmare that is its own making (TTP). As many as 15 cross-border attacks took place in Pakistan in 2022.
In its annual report, the Centre for Research and Security Studies (CRSS) said Pakistan security forces lost at least 282 personnel during 2022 in attacks that included IED ambushes, suicide attacks, and raids on security posts, mostly in the Pakistan-Afghan border regions.
Updated : 2 months, 3 weeks ago IST
According to the statement issued by the Inter-Services Public Relations (ISPR) on Thursday, the Pakistani security forces killed 11 terrorists, including Hafeezullah Tore alias Tore Hafiz, whom the officials termed a "militant commander."
Amid the deteriorating condition of law and order in the country, security agencies were told to make a foolproof security arrangement for Chinese engineers.


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Enjoy sharing stories or if you prefer come along to listen.
The theme of gods and idols could lead to stories of pop idols and movie stars to everyday heroes and tales of fallen idols.
There have been tales of gods dating back for as long as people have been around. In every culture and country on the planet, in all time periods, from man’s beginnings. So there's no shortage of material for our talented tellers to get their teeth into.
People worship all sorts of things so the possibilities for a storyteller are endless and truly fascinating.
Poets, musicians and storytellers all compete for the audience vote for the best performance of the night to secure a place in our prestigious Storyteller of the Year contest.
The Excelsior Club, M33 3FJ
Keep up to date with what’s happening in:
This is a work in progress. Help us improve it.


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Celebrity endorsement is a significant influence on what children and young adults decide to eat. A large number of empirical studies have established that the food served at McDonalds not only leads to obesity but is also unhealthy in other ways. It is a shame that someone who values good health and physical fitness as much as Hrithik Roshan does should promote the consumption of McDonalds fast food, thereby adversely affecting the health of children and young adults.
Vandana Dutt started this petition with a single signature, and now has 137 supporters. Start a petition today to change something you care about.


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When you’re wishing you could be somewhere other than Soho, but you’re stuck in Soho, Ducksoup is the place you should probably go. It’s a natural wine bar and spot just a few steps away from the Soho Theatre, but once you’re inside this slip of a restaurant, you feel more like you’re in a backstreet in Hackney. It’s got a relaxed, personal touch which is a rare find in the West End, and the eclectic menu will have you wondering why you never whip up a plate of bobby beans with charred potato, walnuts and parsley when you’re drinking a glass of wine at home. This spot is perfect for when you want something busy and intimate, and it works as well for a casual date as it does for when you need a bite to eat before a show, or when you’re after a £10 lunch (including a glass of wine).
Where we've featured it
The Best Restaurants in Soho
There are almost too many places to eat in Soho. Here are our pick of the best restaurants to hit up in London’s greatest neighbourhood.
More spots in SohoSee more
If you’re looking for a Tokyo-style dining experience in central London, visit Koya Bar for excellent udon noodles and small plates.
Dum Biryani is a Indian restaurant in a Soho basement. It’s actually a lot more fun than it sounds, and besides the biryani don’t miss the starters.
Mildred’s is a classic vegetarian restaurant in Soho, with an excellent atmosphere and an even better mushroom pie.
More Modern European spotsSee more
Scully serves fantastically OTT food in a sober St James’s setting. The flavours are a slap around the face, in a good way.
One of London’s most exclusive hot spots, Chiltern Firehouse has a reputation for a see-and-be-seen vibe as well as some great food and service.
Chelsea restaurant Elystan Street does very good French and Italian fine dining in relaxed surroundings.
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Aditi is verily the soul of the film. She's someone who has suffered a lot. And her only thought is to make the society ps7 for it in some way. But she also wants a closer of sorts. All these contradictory statements were essayed effectively by her.
It's a cat and mouse game all the way and Amala Paul plays one of the key players in this crime saga. The film zig zags between good and evil and the actress is shown as a victim of circumstances in the film. It's s subtle performance alright.
Andrea plays a bohemian woman who feels she can't adjust to the present society as her free-spirited nature is often misinterpreted, even by those closest to her. It was a fine portrayal indeed by the actress who used her eyes and expressions to get the point across.
Jyotika plays a feminist filmmaker who vows to unite her mother-in-law with her long lost friends. She’s the narrator of the film and also the catalyst which pushes the film ahead. It's a fun role where she gels well with the senior actresses on screen.
She was dressed in two sarees throughout and proved with her powerhouse performance that she doesn't need to be glamourous to deliver at the box office. The film was uncharted territory for her but she sailed through unabashed. We wish more such roles should come her way soon.
The film was all about embracing love and positivity. Revathi plays a woman who gets a chance at love again after being reunited with a former lover and she's a screen stealer alright in her scenes. Her joy, her hesitation and finally her acceptance of the new situation seemed completely real.


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The Ghana Police Service has announced the arrest of one Bukari Salifu, who is said to provide weapons to armed robbers for their expeditions.
Bukari Salifu, 65, was arrested over the weekend following police intelligence.
Prior to his arrest, two suspected robbers who had been arrested when they attempted to rob motorists along the Koluedor-Sege-Accra road had mentioned Bukari Salifu as the one who provides them with weapons for their robberies.
But while ostensibly taking the police to the man, the two rather took the crime-combat team to a bush full of other armed robbers.
“There, the police came under fire as the suspects attempted to escape,” a press release signed by Acting Director-General of Public Affairs ACP Kwesi Ofori on Monday, September 27 noted.
The suspected armed robbers were shot in the process and were rushed to the Police Hospital, where they died.
They are Joseph Dagodzo and Mujahid Abubakar, alias Sule.
Their bodies have been deposited at the Police Hospital morgue.


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Tours and tastings are temporarily suspended. Beginning June 18, our Tap House patio and mercantile are open Thursday – Sunday from 12 – 6 pm. Table service is available on our patio. We’re offering a limited menu from our kitchen and a variety of beer and cider from our outdoor bar.
A tour, a tasting, or both… the choice is yours.
Our 20- to 30-minute tours cost $5 per person and offer a historic overview of Brewery Ommegang with a stroll through the brewhouse, lagering cellar and packaging hall. Questions are encouraged. Visitors aged five and up are welcome on the tour. Tours do require closed-toe shoes and covered shoulders. Please note the minimum age and dress requirements under our FAQs below.
Follow your tour with a guided tasting – sample up to six different Ommegang beers served by a knowledgeable guide. $10 per person.
After a tour and tasting, have a bite to eat in the café, the bar, or on the patio. Paired with any of our 20 beers on tap and more in bottles and cans, it’s an experience to savor.


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Sulfonylureas are widely used to stimulate insulin secretion in type 2 diabetic patients because they close adenosine triphosphate-sensitive potassium (K(ATP)) channels in the pancreatic beta-cell membrane. This action is mediated by binding of the drug to the sulfonylurea receptor (SUR1) subunit of the channel. K(ATP) channels are also present in a range of extrapancreatic tissues, but many of these contain an alternative type of SUR subunit (SUR2A in heart and SUR2B in smooth muscle). The sulfonylurea-sensitivity of K(ATP) channels containing the different types of SUR is variable: gliclazide and tolbutamide block the beta cell, but not the cardiac or smooth muscle types of K(ATP) channels with high affinity. Glibenclamide and glimepiride, on the other hand, block channels containing SUR1 and SUR2 with similar affinity. The reversibility of the different sulfonylureas also varies. Tolbutamide and gliclazide produce a reversible inhibition of Kir6.2/SUR1 and Kir6.2/SUR2 channels, whereas glibenclamide has a reversible effect on cardiac, but not beta-cell, K(ATP) channels. In this article, we summarize current knowledge of how sulfonylureas act on K(ATP) channels containing the different types of sulfonylurea receptor, and discuss the implications of these findings for the use of sulfonylureas in the treatment of diabetes mellitus.
Eight Phase III clinical studies compared the efficacy and safety of liraglutide to other monotherapies or combinations. Liraglutide as monotherapy in doses of 0.9 mg or above showed a significantly superior reduction in HbA1C compared to monotherapies with glimepiride or glyburide. When liraglutide was used as add-on therapy to glimepiride in doses of 1.2 mg or above, the reduction of HbA1C was greater than that in the combination therapy of glimepiride and rosiglitazone. However, liraglutide as add-on therapy to metformin failed to show benefit over combination of metformin and glimepiride. Triple therapy of using liraglutide in addition to metformin plus either glimepiride or rosiglitazone resulted in additional benefit in HbA1C reduction. Most common adverse events were gastrointestinal disturbance such as nausea, vomit, diarrhea, and constipation. During the eight clinical studies, six cases of pancreatitis and five cases of cancer were reported in liraglutide arm, whereas there was one case of each of pancreatitis in exenatide and glimepiride arms, respectively, and one case of cancer in metformin plus sitagliptin arm.
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Eight hearts underwent IPC consisting of two cycles of 5 min global ischemia and reperfusion. Six hearts received a 5-min infusion of 10 microM glimepiride, six hearts received a 5-min infusion of 50 microM glimepiride, and seven hearts received a 5-min infusion of 10 microM glibenclamide before IPC. Seven hearts received a 5-min infusion of the selective mitochondrial K(ATP) channel opener diazoxide (50 microM). Other hearts received a 5-min infusion of 10 microM glimepiride (n = 6), 50 microM glimepiride (n = 6), or 10 microM glibenclamide (n = 7) before diazoxide. Seven hearts served as a control. All groups then were subjected to 1 h of regional ischemia, followed by 1 h of reperfusion. LV pressures, monophasic action potential duration (APD(50)), and infarct size were measured.
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Baseline HbA1c correlated to Δ HbA1c (r (2) = 0.36, slope = -0.54 [95% CI -0.55, -0.53; p < 0.0001]) for both treatments. With sulfonylureas, the slope of the correlation was steeper in the observational study than in RCTs (interaction coefficient = -0.327, p < 0.001), whereas for vildagliptin, the slope was virtually identical in the observational study and the RCTs (interaction coefficient = 0.024, p = 0.175). For any given baseline HbA1c, Δ HbA1c with sulfonylureas was smaller in real life than in RCTs, whereas Δ HbA1c with vildagliptin was the same.
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We demonstrate that glibenclamide and glimepiride modulate FXR activation in a reporter-gene assay and induce FXR target genes in HepG2 cells. Within the docking experiments and molecular dynamics simulation, we found glibenclamide interacting with the ligand-binding domain of FXR and with helix 12.
DPP-4-i are an additional choice in the group of anti-hyperglycemics. Their principal advantage is a low incidence of hypoglycemia, making these agents desirable in patients such as the elderly and those with cardiac disease. Several large trials have hinted at less cardiac risk with DPP-4-i than with sulfonylureas. The CAROLINA Trial comparing linagliptin and glimepiride may provide a conclusive answer to this question.
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Two review authors independently selected trials, assessed risk of bias, extracted data and evaluated overall quality of the evidence using GRADE. We summarised data statistically if they were available, sufficiently similar and of sufficient quality. We performed statistical analyses according to the statistical guidelines in the Cochrane Handbook for Systematic Reviews of Interventions.
To examine comparative efficacies of adjunctive therapy with insulin in subjects with type 2 diabetes manifesting lapse of glycemic control while receiving various individual sulfonylurea drugs.
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Altogether, 93 episodes of SH were registered, 37 on glimepiride and 56 on glibenclamide. The characteristics of the glimepiride- versus glibenclamide-induced SH were as follows: initial blood glucose 1.9+/-0.66 mmol/l versus 1.8+/-0.89 mmol/l, P=0.17; age 77+/-11.2 years versus 78+/-9.6 years, P=0.35; HbA1c 5.4+/-0.7% versus 5.2+/-0.9%, P=0.18; creatinine clearance 38+/-23 ml/min versus 54+/-32 ml/min, P=0.005; co-medication 6.2.+/-3 versus 3.6+/-3 preparations, P< 0.0001. Even very low doses of glimepiride (0.5 mg) and glibenclamide (0.88 mg) were associated with SH. Prolonged hypoglycaemia requiring more than 12 h i.v. glucose administration occurred in 8 of 37 of the glimepiride-treated subjects and 5 of 56 of those on glibenclamide. Prolonged hypoglycaemia necessitated infusion of 308+/-256 g (104-862 g) i.v. glucose over 43+/-16 h (24-64 h) in glimepiride-treated patients compared with 168+/-98 g (66-300 g) over 33+/-28 h (14-80 h) in glibenclamide-treated patients. Impaired renal function was present in 11 of 13 of all patients with prolonged hypoglycaemia and impaired liver function in 1 of 13.
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The studies were performed on healthy male Wistar rats with a body mass of 220+/-30 g, fed with LSM-type standard chow, and given water ad libitum. Transient or prolonged hyperglycemia was induced by intraperitoneal administration of streptozotocin. Blood samples were taken from the right heart ventricle to heparinized test tubes and centrifuged for 10 minutes at 700 i. g. Plasma was collected and the glucose level was determined. From each animal 1 g of skeletal muscle and 1 g of liver were collected as well, placed in liquid nitrogen and stored until determination of the affinity and number of receptors.
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Despite the current guideline's recommendation of a timely stepwise intensification therapy, the "clinical inertia", termed as the delayed treatment intensification, commonly exists in the real world, which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy. In this clinical trial performed in 237 centers in China, 5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks. The patients who did not reach the glycated hemoglobin A1c (HbA1c) goal were then further randomized into glimepiride, gliclazide, repaglinide, or acarbose group for an additional 24-week triple therapy. A mean HbA1c reduction of 0.85% was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks. Further HbA1c reductions in the 24-week triple therapy stage were 0.65% in glimepiride group, 0.70% in gliclazide group, 0.61% in repaglinide group, and 0.45% in acarbose group. The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide, but not for acarbose, compared with glimepiride, when added to metformin/sitagliptin dual therapy. The incidences of adverse events (AEs) were 29.2% in the dual therapy stage and 30.3% in the triple therapy stage. Metformin/sitagliptin as baseline therapy, with the addition of a third oral antihyperglycemic agent, including glimepiride, gliclazide, repaglinide, or acarbose, was effective, safe and well-tolerated for achieving an HbA1c <7.0% goal in type 2 diabetic patients inadequately controlled with previous therapies. The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia.
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Improved efficacy and greater compliance were observed in response to treatment with glimepiride compared with acarbose, in patients with Type 2 diabetes.
This large-scale study, conducted under conditions approximating to current medical practice, confirms that glimepiride has a favourable risk-benefit ratio in type 2 diabetes mellitus. Diabetes duration and previous treatment with OADs reduced the likelihood of being a responder to treatment.
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The development and progress of antidiabetic drugs (e.g., insulin preparations and hypoglycemic drugs) are retrospectively investigated in Japan. Their influences on the treatment of diabetes mellitus (DM) and its epidemiological aspects are also discussed. 1) Insulin preparations: Insulin was introduced for DM therapy in 1925, two or three years after its discovery in Canada. The preparations were raw extracts of bovine or porcine pancreas. These did not prevail widely in Japan because of the low incidence of DM before World Wan II. After the war, a shortage of mammalian materials compelled the use of fish pancreatic tissues such as bonito and/or tuna for insulin production. Insulin infection, so-called regular insulin, was first promoted in the 6th "Pharmacopoeia Japonica" (JP6) in 1951 and has been maintained to the present edition (JP14, 2001). Although depot-type insulin preparations were developed in the USA and Europe during the war, the introduction of those preparations to Japan was delayed until 1951, when Protamine zinc insulin appeared. Globin zinc insulin and Isophane insulin were introduced for clinical use in 1952 and 1955, respectively. These were also adopted for JP7 (1961). Biphasic-type insulin, which has a rapid onset and long duration of activity, appeared in 1965. Purified preparations from bovine or porcine sources have been available since 1980, which might be a strong reason for the decrease in insulin allergy. Insulin from animal origin has been supplied for almost 60 years since its discovery. Amino acid sequences of insulins from various species of animals were determined by the pioneering studies of Sanger and his associates. Human insulin, which differs from porcine insulin by only one amino acid, was produced by Novo researchers in 1982 using a semi-synthetic method. Then the Lilly group soon succeeded in obtaining human insulin by recombinant DNA technology in the same year. Both products were introduced to Japan in 1985, and the recombinant products prevailed throughout the 1990s. Human insulin analogues (i.e., Insulin lispro and Insulin aspart) appeared in 2001. These are applied for after-meal glycosmia owing to their ultrarapid onset of activity. Self-injection by DM patients was legalized in 1981. To make the infection technique sure and easy, cartridge (pen-type) and disposable kit-type needles were devised in the 1990s. 2) Oral hypoglycemic drugs: Instead of the exclusive parenteral usage of insulins, there was also demand for oral dosage forms. The first of the sulfonyrlurea (SU) group, BZ-55, was used for DM clinically in 1955 in Germany. But it was soon withdrawn because of its antibacterial action. This led to the development of various SU groups. Tolbutamide (1956), chlorpropamide (1959), acetohexamide (1964) and tolazamide (1961) were introduced to Japan as first-generation SUs. Then glyclopyramide (Kyorin, 1965), glybenclamide (1971), gliclazide (1984) and glimepiride (1999) appeared as the second-generation SUs. These were used orally for Type 2 diabetes. Biguanide (BG) group, phenformin HC1 (1959), metformin HC1 (1961) and buformin HC1 (1961) had also been in use by oral treatment of Type 2 diabetes. SU appears to act by increasing the sensitivity of b-cells, which secrete insulin. BG probably exerts by increasing glucose transport across the membranes of target organs. 3) New types of antidiabetic drugs: a-Glucosidase inhibitors (i.e., acarbose: Bayer, 1993; and voglibose: Takeda, 1994) act on hyperglycemia after meals by decreasing glucose absorption. Thiazolidinedione compounds, such as troglitazone (Sankyo, 1995) and pioglitazone HC1 (Takeda, 1994) act by increasing the insulin sensitivity of the target tissues. These are useful for Type 2 DM patients when SUs are ineffective. Nevertheless, troglitazone was discontinued in 2000 due to severe liver damage. Nateglinide (Ajinomoto Co., 1999), which is a D-phenylalanine derivative acting similar to SUs, is useful orally for after-meal hyperglycemia of Type 2 diabetes. Epalrestat (Ono Yakuhin Co., 1992) is effective for diabetic neuropathy by reducing the formation of sorbitol. These anti-DM drugs were recently studied and developed in Japan. 4) The Japan Diabetes Society proposed a guideline on diagnostic criteria and treatment of diabetes mellitus (DM) in 1999 and revised it in 2002. DM is classified as insulin-dependent DM (Type l) and non-insulin dependent DM (Type 2). Type 1, juvenile onset DM, requires insulin therapy to prevent ketosis and to sustain life. Treatment of type 2, adult onset DM, is recommended as a step-by-step method, starting with dietary-exercise therapy, followed by oral hypoglycemic drugs and then insulin therapy. DM patients with complications should have a therapy devised to match their circumstances. 5) Epidemiological aspects: The mortality rate of DM compared to the time of drug appearance was traced from 1920 to 2000. The curve goes down slowly in the time frame of World War II, but rises from 1950 to 1970. The elevation could not be suppressed by the appearance of SUs, BGs or improved insulin preparations. The curve runs flat from 1980 to 1990, which might be related to the use of purified insulin or human insulin therapy. The mortality rate of DM indicates that death by hyperglycemic coma and other deaths resulting from complications are excluded. The survey of the principal cause of death by DM during the period of 1981-1990 indicates that the death rate due to hyperglycemic coma is only 1.7% of the total deaths caused by DM. The effect of drug therapy on all of the death resulting from DM is not detected. Hospital visitation and admission rates of the DM patients have been recorded since 1952 in Japan. This curve is rising continuously, and none of the antidiabetic drugs has been able to suppress it. These data show that the antidiabetic drugs relieve DM symptoms through their effective hypoglycemic actions, but that they cannot suppress the mortality rate of DM. It is possible that none of the drugs currently available can suppress the increasing tendency of DM patients.
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Canagliflozin 100 and 300 mg provided durable glycemic improvements and body weight reductions compared with glimepiride over 104 weeks. At Week 52, the proportion of patients who achieved reductions in both HbA1c and body weight was 72.4% with canagliflozin 100 mg, 78.5% with canagliflozin 300 mg, and 26.8% with glimepiride; similar results were observed at Week 104 (65.5%, 71.1%, and 26.8% with canagliflozin 100 and 300 mg and glimepiride, respectively). The AE profile of canagliflozin was comparable to that observed in previous studies, with increased incidence of AEs related to the mechanism of SGLT2 inhibition (e.g., genital mycotic infections, urinary tract infections, and osmotic diuresis-related AEs) and a low risk of hypoglycemia.
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As assessed by the composite outcome of HbA1c <7%, no hypoglycaemia and no weight gain, liraglutide was clearly superior to the other commonly used therapies. However, the long-term clinical impact of this observation remains to be shown.
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The addition of sitagliptin 100 mg/day produced a statistically significant reduction in mean HbA1c level (mean HbA1c reduction of 0.99±0.85%, P<0.01). In the group taking a combination of sitagliptin and metformin (n=143, initial mean HbA1c level=7.48%), the reductions in HbA1c, 2-hour postprandial glucose, and fasting glucose levels were 0.72±0.76% (P<0.01), 47±65 mg/dL (P<0.01), and 15±44 mg/dL (P<0.01), respectively. In the group taking a combination of sitagliptin, glimepiride, and metformin (n=125, initial mean HbA1c level=8.42%), the reductions in HbA1c, 2-hour postprandial glucose, and fasting glucose levels were 1.09±0.86% (P<0.01), 62±64 mg/dL (P<0.01), and 31±45 mg/dL (P<0.01), respectively. In the group taking a combination of sitagliptin, glimepiride, metformin, and α-glucosidase inhibitor (n=63, initial mean HbA1c level=9.19%), the reductions in HbA1c, 2-hour postprandial glucose, and fasting glucose levels were 1.27±0.70% (P<0.01), 72±65 mg/dL (P<0.01), and 35±51 mg/dL (P<0.01), respectively. In the group that had previous hypoglycemic events and that changed from glimepiride to sitagliptin, HbA1c level did not change but fasting glucose increased significantly (14±29 mg/dL, P<0.01).
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Pharmacodynamic profiles for plasma glucose and insulin showed no statistically significant differences among genotype groups, and parameters were not different from one another. There were no association of the KCNJ11, NOS1AP, TCF7L2 and ABCC8 gene polymorphisms and the efficacy of glimepiride.
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To observe the intervention effects of electroacupuncture at "Yishu" (EX-B 3) on rats with type-2 diabetes mellitus (T2DM), so as to provide experiment references for acupuncture to treat T2DM.
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We used the indirect method for estimating the rate of prevalence of diabetes based on antidiabetic drug in the Madrid Community. We studied the consumption or oral antidiabetics (OH) and insulin (IN) in all the Madrid Community Area from 1996 to 2002. To make consumption uniform we used the daily doses/1,000 inhabitants/day (DHD). The total consumption was obtained using the official billing data and the annual population data provided by the "Institute Madrileño de Salud".
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These results confirm earlier reports that insulin glargine provides superior glycemic control with less hypoglycemia and demonstrates that these benefits are consistent between different ethnicities.
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The GAME regimen provides long-term glycaemic control as well as stabilization of body weight in about 60% of type 2 patients presenting with secondary failure.
Genotyping for the CYP2C9*2 and CYP2C9*3 alleles currently appears to have no clinical implications for dosing of sulfonylureas in primary care patients with Type 2 diabetes mellitus.
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HbA (1c) change was significantly greater in the BIAsp 30 plus met group than the glarg plus glim group (between-group difference: -0.5% (95% CI: -0.8; -0.2); P=0.0002). Mean prandial plasma glucose increment was significantly lower for BIAsp 30 plus met compared with glarg plus glim: 1.4+/-1.4 mmol/l vs. 2.2+/-1.8 mmol/l; P=0.0002. During the maintenance phase (weeks 6-26), one major hypoglycemic episode occurred in each group; 20.3% and 9% of patients experienced minor hypoglycemic episodes in the BIAsp 30 plus met and glarg plus glim groups, respectively ( P=0.0124). At end-of-trial, mean daily insulin doses were 0.40 U/kg BIAsp 30 and 0.39 U/kg glarg. Glarg plus glim-treated patients experienced significant weight gain of 1.5 kg (95% CI: 0.84; 2.19; P<0.0001). Weight change with BIAsp 30 plus met of +0.7 kg was not statistically significant (95% CI: -0.07; 1.42; P=0.0762).
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There was no significant difference between the 2 patient groups for glimepiride in terms of mean peak concentration (C(max)) (p = 0.0807), time to reach C(max) (t(max)) (p = 0.9916), AUC(0-24) (p = 0.2609), AUC(0- infinity ) (p = 0.1275), or terminal half-life (p = 0.3076). Mean t(max) values and relative total clearances for the 2 groups were also equivalent. Some differences were noted with respect to the pharmacokinetics of metabolites between the groups. In particular, over a 24-hour period, the morbidly obese group excreted statistically significantly greater amounts of MI (p = 0.0430) and MII (p = 0.0051) compared with the normal-weight group. However, none of the differences was considered clinically significant since these metabolites do not have meaningful pharmacologic activity.
The aim of the study was to determine the influence of glimepiride on the binding kinetics of insulin with its skeletal muscle receptor in rats with transient and prolonged hyperglycemia induced by streptozotocin.
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Rg, Gm and Gli can all decrease blood glucose effectively in newly diagnosed T2DM patients, while Rg performs outstandingly in the aspects of improving early-phase insulin secretion, glucose excursion, postprandial lipids and 8-iso PGF(2alpha).
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The present study was undertaken to evaluate the antihyperglycemic, antihyperlipidemic and hepatoprotective effect of a traditional unani formulation "Qurs Tabasheer" in streptozotocin (STZ) induced diabetic wistar rats. Up till now no study was undertaken to appraise the efficacy of "Qurs Tabasheer" in the diabetic rats. Qurs Tabasheer is a unani formulation restraining preparations from five various herbs namely Tukhme Khurfa (Portulaca oleracea seed), Gule Surkh (Rosa damascena flower), Gulnar (Punica granatum flower), Tabasheer (Bambusa arundinasia dried exudate on node), Tukhme Kahu (Lactuca sativa Linn seed).