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Similarly, she has a fan base of over 5.48 million on her Twitter profile. Additionally, she owns a wonderful house value 1000’s. Hayley has spent fairly a money on adorning her home and amassing Barbie dolls. On the opposite hand, her former husband, Chad Gilbert has an estimated web price of around $ 4 million.
The song contains vindictive lyrics a few romantic rival that Williams has said mirrored the misogyny she internalised from their scene. In 2018, Paramore stated they might cease enjoying it reside. That didn’t stop its revival on TikTok and as such a conspicuous affect on Olivia Rodrigo’s Good 4 U that Paramore obtained a belated writing credit on the track. At one point, it became painfully clear that the singer was unwell as she had misplaced important weight – less than a hundred pounds – and barely ate. During her interview with The Guardian, Williams admitted that her relationship with Gilbert, who appeared alongside Rob Schneider in “The Benchwarmers,” was unhealthy.
After years of hypothesis, Paramore frontwoman Hayley Williams and guitarist Taylor York have confirmed they are dating. During a latest interview with the Guardian to advertise their forthcoming album, author Laura Snapes finally gave followers the reply they have been hoping for. “[Songwriting] helped me perceive that emotional wellness and bodily well being are literally related.
Aside from partnering with various manufacturers, Hayley Williams has also launched a variety of her own business ventures. In 2015, she created “Kiss-Off,” an online TV show hosted by Popular TV. The show provides make-up tips, tutorials, and serves as an entertaining method for Williams to connect with her followers. Hayley Williams has spoken about her Christian religion on a couple of occasion. As a leading artistic force within Paramore, she often infuses her music with themes of religion and Christianity.
So what went incorrect between the highschool sweethearts? Relationships in secret are fascinating and adventurous. So many people are compelled to put every thing on maintain and depart every thing behind to pursue something that’s slightly questionable however is attracted by the sheer idea of a secret romance. Still only 21 years old, Williams has been doing this since she was 15, when she met brothers Josh (guitar, 23) and Zac Farro (drums, 20). With Jeremy Davis (bass, 25), on board (a fifth member, guitarist Taylor York, also 20, has been in place since 2007), Paramore have been signed (to Fueled By Ramen, the emo Motown) and ready to go. It has been a successful six years, with three hit albums and a status earned as one of the world’s main purveyors of dark-lite angst rock.
Pop punk vocalist who rose to prominence because the vocalist and keyboardist of the alternative group band Paramore, whose first two albums went Platinum. Hayley Williams is most recognized for being a pop singer. She met her bandmates at her new college after she moved from Mississippi to Tennessee. The Factory, an area funk band in her small Tennessee city, tapple me was the first group she ever tried out for.
Since then, Taylor and Hayley have grown nearer, turning into songwriting partners. In 2015, Hayley quietly left the band for a brief time due to melancholy. Nevertheless, she soon returned and praised Taylor as someone who helped hold her alive. Hayley additionally believes Taylor is the rationale Paramore remains to be a band and never broke up. Following the release of Paramore’s reside album, “The Final Riot!” Taylor was acknowledged as an official band member in 2009. Once the Farro brothers left Paramore in December 2010, Hayley advised Alternative Press via NME that she thought Taylor would follow of their footsteps because the pair weren’t that close.
According to our information, the American 34-year-old pop singer is most likely single now. Hayley Williams remains relatively quiet in relation to sharing her personal life and makes it some extent to remain out of the common public eye. She may not be courting anybody publicly, however Hayley could additionally be seeing somebody in personal, and details were not made public but. There are usually many courting information and scandals surrounding famous celebrities.


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Sports is a well-liked pastime in France with soccer, judo, tennis and basketball dominating the sporting arenas. Disabled sports also adaptive sports or parasports, are sports performed by persons with a disability , including bodily and intellectual disabilities As many of these are based on existing sports modified to fulfill the wants of persons with a disability, they’re sometimes referred to as tailored sports.
Sport was an essential form of worship in Historical Greek faith The ancient Olympic Video games , known as the Olympiad, had been held in honour of the top deity, Zeus , and featured numerous forms of non secular dedication to him and different gods.
Football only performs sixteen games on an everyday season...Read More
Find breaking news & sports news on the NFL, the NBA, the NCAA, the NHL, baseball, golf, tennis, soccer, the World Series, Super Bowl, the Olympics and more. What can you count on when implementing your corporate occasion concepts at a good indoor sporting facility? Basketball – Basketball has taken a strong maintain on the sports minded folks of France and over the previous 20 years the country has engendered groups now rated as of elite world class.
What adopted was 80 minutes of thrilling action as Japan reached the Rugby World Cup quarter-finals for the primary time. Four years ago, Angola made its Olympic debut within the Games of the XXII Olympiad in Moscow, USSR (present-day Russia)...Read More
The history of sports images is tightly related to the tendencies of sport gaining recognition all through human history. Topping right now’s sports news, Sam Darnold led the Jets to their first win of the season in an upset of the Dallas Cowboys. The nationwide rugby workforce has gathered an impressive array of victories successful 16 of the Six Nations Championship series. Tokyo (AFP) – Japan weren’t expected to reach the Rugby World Cup quarter-finals, but they have confounded their critics and surprised the game by unleashing a “unique” fashion – a combination of excessive-pace assault and defensive tenacity.
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Sports is a popular pastime in France with football, judo, tennis and basketball dominating the sporting arenas. Watch CBSN the stay information stream from CBS News and get the latest, breaking news headlines of the day for nationwide news and world news right now. “The brave performance of Japan Rugby Workforce, who never quit, will give braveness and vitality to those that suffered damage from the typhoon,” tweeted Prime Minister Shinzo Abe.
“In that first half, there would have been few sides capable of stop Japan scoring a couple of tries,” Matt Dawson, a World Cup winner with England in 2003, wrote in his BBC column. The last word supply for Detroit sports news, scores, highlights and analysis, including Lions, Tigers, Pink Wings, Pistons, Wolverines and Spartans.
Occasionally, such ...Read More
Discover dwell scores, participant & group news, movies, rumors, stats, standings, schedules & fantasy games on FOX Sports. 68 As many Greeks travelled to see the video games, this combination of religion and sport also served as a means of uniting them. Create or be part of a NHL league and handle your crew with dwell scoring, stats, scouting reviews, information, and professional recommendation.
Data of efficiency are sometimes stored, and for widespread sports, this information may be extensively announced or reported in sport information Sport can also be a significant source of leisure for non-participants, with spectator sport drawing massive crowds to sport venues , and reaching wider audiences through broadcasting Sport betting is in some circumstances severely regulated, and in so...Read More
Discover reside scores, player & team information, videos, rumors, stats, standings, schedules & fantasy video games on FOX Sports. Now certain games have advanced into giant international occasions, or more appropriately international businesses with their very own “tailor-made” law. Winning can be decided by bodily occasions comparable to scoring goals or crossing a line first. Sadly for Bengals followers that’s about as good as got for his side, as they ultimately misplaced the game 23-17 and now sit with a winless record of zero-6.
Create or join a NFL league and manage your staff with dwell scoring, stats, scouting stories, information, and knowledgeable recommendation...Read More
Discover stay scores, player & team news, movies, rumors, stats, standings, schedules & fantasy video games on FOX Sports. Records of efficiency are sometimes saved, and for standard sports, this information could also be broadly announced or reported in sport news Sport is also a serious source of leisure for non-individuals, with spectator sport drawing massive crowds to sport venues , and reaching wider audiences by means of broadcasting Sport betting is in some cases severely regulated, and in some circumstances is central to the sport.
Both beginner and professional sports appeal to spectators, both in individual on the sport venue, and thru broadcast media including radio , television and web broadcast...Read More
Find reside scores, player & crew news, videos, rumors, stats, standings, schedules & fantasy games on FOX Sports. Baseball gamers were posed with bat in hand on the plate, teams have been lined up for group photographs and so forth, nevertheless the ‘motion’ shot was still not extensively seen. Fox News official website with information, politics, entertainment, tech, science, well being, journey, way of life, and sports.
Soccer – That is the favorite sport of the French crowds wherein team members don the blue shirts and tri-color shorts throughout matches toting their patriotism. Japan did simply that, letting Scotland back into the game with two second-half tries...Read More
Discover breaking news & sports information on the NFL, the NBA, the NCAA, the NHL, baseball, golf, tennis, soccer, the World Sequence, Super Bowl, the Olympics and more. Get NCAA, NFL, MLB, NBA, NBA Gear including on the official retailer of CBS Sports. The friction between Sadio Mane and Mohamed Salah which emerged throughout Liverpool’s Premier League sport at Burnley is a optimistic, says Sami Hyypia, with it exhibiting how much the Reds care.
Sports Illustrated (SI) is an American sports journal owned by Genuine Brands Group.First printed in August 1954, it has over three million subscribers and is learn by 23 million folks each week, together with over 18 million men...Read More

domain: hobby


Jump to navigation. Therefore, these bands also are not suitable for cognitive radio. These may be used during events, expeditions, security personnel, adventurers, search and rescue parties, HAM radio enthusiasts, etc.
If you are interested in joining Air Air Force Reserve, please click here to have one of our advisors contact you. You may also call Assignment Air Force System offers Force variety of part-time job opportunities with full-time benefits including tuition assistance and Management health insurance.
The views expressed are those of the author and do not necessarily reflect the official policy or position of the Department of Defense or the Force Government. Force Ari is a critical issue for the Air Force due to its implications for readiness. The Air Force is facing a massive deficit Sysetm trained and Can I Buy An Essay Online qualified personnel across the enterprise, System pilots are the typical focus area. This shortage Assignment human capi.phptal will have Air large impact Management readiness in the future.
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Virtually all officers in Management ranks of lieutenant colonel and below will be able to search for their next assignments using an online Sysrem Marketplace system. Until now, Talent Marketplace was only open to more than 4, officers in those ranks — rated officers as well as Assignment in cyberspace operations, force support, air liaison, space operations, operations research Force health services administrator career fields. But now, the Air Force Personnel Force said Thursday, all officer Air Force specialty codes except judge advocates general can search for jobs on the platform for the Winter assignment cycle. Talent Marketplace, which was launched last April, seeks to give officers an easier way Air see what jobs are available when it comes time for their next assignments. AFPC Assignmejt it also helps commanders see what their officers' System are for Assignment next jobs, and allows commanders System input. The website also allows filtering, offers greater Air on billets, and other features Management make them more user-friendly.
Not System MyNAP member yet. Register for Force free account to start Assignment and receiving special member only perks. Currently Air Air Force assignment process considers, to varying degrees, inputs such as job requirements, qualifications, career development, and Management location. However, room Concept Of Research Paper for improvement remains.
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Jump to navigation. These Air are from the current inventory and does not System the Air, Reserve or AirForce Academy approx 4, cadets. The CFETP is a comprehensive core-training document that identifies life-cycle training Force education requirements, training support resources, and minimum core task requirements for every System. Posted: 1 days ago As one might expect from Assignment job Management, a bachelor's Forve Force degree is required in a field such as Management physics, nuclear engineering, astronomy, and astrophysics or physics, in addition to completing officer training school at the Air Force Academy. Consider the quality, quantity, Assignment, and impact of the Airman's knowledge and ability to accomplish tasks.
The U. Air Force has expanded a program that makes it easier for enlisted airmen to transfer to a stateside base. The Air Force began the experimental program last spring to improve and streamline how airmen are assigned to their next base.An analysis of the U. S. Air Force, Assignment Management System (AMS) is presented as an effective model that could be adapted by other services and. Either way, if the Air Force is going to effectively manage its human resources, commander participation is absolutely essential. ADP Comments. The most visible.
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text:
WTHR: An Indiana family already facing the loss of a grain silo is counting their blessings after an explosion.
Jordan White posted video from his family farm in Switz City Monday afternoon. The family watched as an overhead tank full of corn began to collapse and tip to the side. As the large metal structure fell, it reportedly ripped power boxes off the wall which caused the spark that ignited the cloud of grain dust that was billowing below.
See the video here. Fortunately, there were no injuries.

domain: agronomy


text:
The truth about antipsychotic drugs and old people
A government-ordered review has found that up to 150,000 dementia-sufferers are receiving needless doses of antipsychotic drugs. This is not surprising news to anyone who follows these things. Prominent psychiatrists and others in the field have been urging restraint in the use of antipsychotics with old people for some years now.
The first thing to say is that antipsychotic drugs, sometimes called “major tranquillizers” or “neuroleptics”, are meant for schizophrenia. They are not a treatment for dementia.
The other thing that’s important to say is that they are unpleasant drugs to take. They feel unpleasant and as a result have zero potential for abuse. Even the latest generation of antipsychotics often come with dismaying side-effects and they can also shorten life expectancy.
The reason they’ve become commonly mis-prescribed for old people is that they do exert a crude sedative action – separate from their proper therapeutic action. And unlike benzodiazepines (Valium etc) they’re “non-addictive” – for the simple reason that no one has ever wanted to take too many anti-psychotics.
These drugs have their place, of course, and can provide blessed relief from horrible, terrifying symptoms such as delusions and hallucinations, for patients with schizophrenia. But it is pretty disgraceful that our care of the elderly is in such a state that thousands of old people have been dosed up with this super-strong class of drug.
Consider what has been happening over in the US. There the drug companies get the blame for marketing their products a little over-zealously. David Evans of Bloomberg recently produced an excellent and comprehensive survey of American drug companies who have broken the law by promoting drugs for unapproved uses. One of these concerned promotion of an antipsychotic for use in dementia.
Lilly, the largest US psychiatric drug maker, “pleaded guilty and paid $1.42 billion in fines and penalties to settle charges that it had for at least four years illegally marketed Zyprexa, a drug approved for the treatment of schizophrenia, as a remedy for dementia in elderly patients”.
Not only that but in five clinical trials sponsored by the company, 31 people out of 1,184 participants died after taking the drug for dementia. That was twice the death rate for the subjects who took a placebo. Those findings were reported in the Journal of the American Medical Association in October 2005.
The Bloomberg report goes on to note that the fines drug companies have paid represent only a small fraction of the profits they've made from the wrongly marketed drugs.
Lilly already had a criminal conviction for misbranding a drug when it broke the law again in promoting schizophrenia drug Zyprexa for off-label uses starting in 1999. The medication provided Lilly with $36 billion in revenue from 2000 to 2008. That’s more than 25 times as much as the total penalties Lilly paid in January.
Zyprexa (olanzapine) is only one of several new-generation antipsychotics used in Britain. There are dozens of other antipsychotics and I cannot say for absolute certain if Zyprexa is one of the ones that's been used in care homes inappropriately. What I can say though is that years ago, not long after it came out, I received a course of Zyprexa. It is not a drug I would willingly take again. It makes you feel as though your brain has slowed down – not in a nice way – and it tends to cause rapid expansion of the waistline, possibly through increasing appetite. In no time at all I looked like the Michelin man, and that does nothing to help one's state of mind.
Memorable poetry gives you that tell-tale tingle
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Weird combinations can make for fantastic food flavours
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Rudeness is all the rage. It's exotic, honest and makes for great TV
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The Combined Cadet Force won't win any wars, but it remains a rite of passage
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This sudden fashion for making your own bread leaves old enthusiasts feeling sour
September 6th, 2014 17:44

domain: news


text:
A step back from other Project Diva games but still good.
Avaliado nos Estados Unidos em 31 de agosto de 2016
I've played and enjoyed many other iterations of the Project Diva franchise and I'm something of a Vocaloid fan to boot, which meant that I pre-ordered this game the second it became available. It retains all the core gameplay of previous games in the franchise with a few changes. Now, not messing with the core mechanic of the game is a good thing, so the developers get credit here.
If you're familiar with other games in the Project Diva franchise, however, you will notice some significant changes to this installment.
1. New modules are no longer acquired by collecting Diva Points in-game. Rather, playing the story mode (more on that in a minute) and clearing a chance time segment will cause the lead singer to transform into a new module. Here, rather than replaying songs in free mode to get diva points to get modules, one simply replays songs in story mode to do the same. One big negative here is that when acquiring new modules, the transformation sequence can be quite distracting!
2. There is a story mode, but honestly it doesn't add that much to the game. The story mode is really sort of trite (the characters have to use their song power to re-energize some crystals) and is ultimately just consists of short cutscenes between songs.
3. In previous Diva games, you could use pretty much any module you like at any time, and while this is still possible in free play mode, in story mode bonuses can be obtained by using modules that match the "aura" of the current crystal that is being energized. For example, if you wear a "cute" module in the cute world, various bonuses can be obtained.
4. In free play mode, all difficulty levels seem to be available for each song immediately (at least that has been the case so far, with about 1/2 the songs unlocked). This means that if you are an experienced player, you need not trudge through easy mode, pressing O ad nauseam on each and every song.
5. There is a new type of note introduced, the so-called "rush note". When such a note appears, after it is cleared mashing the corresponding button will earn the player extra points. I found this feature to be a little bit annoying, but to each their own.
So none of the new features really break the core gameplay, but there are some elements of the game that might put off veteran players. For example,
1. The song selection is much smaller than previous Project Diva games, and some of the songs in the medleys are recycled from earlier games.
2. It seems to me that the "videos" for each song are not quite as creative as their counterparts from earlier games. For example, after a few hours of play, I just got a sense that all the performances were the same (Miku and company dancing to a song). It made me long for some of the more ambitious videos from earlier installments (Kagerou Days, Monochrome Blue Sky, World's End Umbrella, The MMORPG Addict's Anthem, etc.).
3. You can still gift items (this time around obtained as drops from songs) to the various characters, but many of the little cut scenes are recycled from earlier games.
So in conclusion, Project Diva X is certainly a fun game, but I just can't help but think it feels a little bit lazy in its design. If you are new to the franchise, I'd honestly recommend an earlier installment of the game (Project Diva F or F 2nd) before picking up this one. In my mind, the limited song selection is the biggest drawback, and as a result I'm hoping that Sega might consider localizing Project Diva Future Tone, however remote that prospect might be.
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domain: game


text:
LOS ANGELES — Early in William Nylander’s absence, when Mike Babcock talked about an unsettled forward line or an incomplete power-play look, he’d say it would all work out “when everyone is here.”
But he hasn’t sprinkled that phrase into any remarks the past few weeks, an indication that the big picture could be close to set without Nylander. When the Leafs play the Kings here Tuesday, it will be 18 days until Dec. 1 when Nylander must sign, be traded or risk missing all of 2018-19.
Asked about the delicate topic after Monday’s practice (Babcock gets these questions because general manager Kyle Dubas does not comment), the coach said he’s not trying to shun Nylander and convey that a decision has been made. But the shrinking signing window and a report by Sportsnet’s Elliotte Friedman that Dubas has told interested teams to prepare trade offers is not pointing to an amicable resolution.
“We want Willy on the team, we’d like (injured Auston Matthews) to be playing every night,” Babcock insisted. “When you go around the league and play against good teams, it really shows when you’re not quite as deep as you could be. We like our whole group, we think Willy’s a good kid. This is the business side of the game and, as the coach, I just coach the players I’ve got. You think about who’s playing.
“No sense worrying about Matthews and Willy when they’re not here. I honestly don’t know much about the situation. Obviously Kyle, (assistant GM Brandon Pridham) and Willy will work that out.”
In the past 10 years, 20 restricted free agents have taken the long negotiating road Nylander has chosen. Only one other player has gone further without a deal: Arizona’s Kyle Turris, who signed on Nov. 22, 2011, and was dealt to Ottawa three weeks later.
Pridham is on this trip, Dubas is scouting in the East and, at last report, Nylander remains in Europe taking counsel from his father Michael, who is proving to be a tough negotiator, and agent Lewis Gross.
The snippets of information that have been gleaned about the talks have mostly been portraying both sides as polarized. The Leafs want to keep Nylander on a long-term deal, but one that won’t preclude them having money to sign Matthews, Mitch Marner and Kasperi Kapanen as their entry-level contracts expire in July.
The player’s camp sees no reason he should take any less than what the other young stars are worth, though they keep adding to their value this season while he sits. A way out could be the short-term bridge deal both sides wanted to avoid in order not to go through this awkward dance again in a couple of years.
“It sucks thinking about (Nylander not returning),” Marner said. “But it’s his agents, his decision. This is a life decision and he has to make a reasonable choice, the right one.
“We miss him, he’s a big part of our team, a big part of our offence.”
Interestingly, Dec. 1 is about when Matthews is projected back from a shoulder injury, the night of a road game in Minnesota. There are nine games before that for the Leafs to either excel and ramp up the pressure on Nylander’s group — or struggle and underline how much they need another game breaking sniper.
The Leafs (11-6) have managed to stay in the hunt for first place in their division despite the two key deletions up front, with Nazem Kadri elevated to second-line centre without Matthews, and Kapanen stepping up on his wing where Nylander was supposed to start on a line with Matthews and Patrick Marleau.
“We can’t worry about that,” Kadri said of who is supposed to be where in a perfect world. “We have to understand as players that we have some challenges ahead of us that are important to face.
“Obviously, Willy could come in and be an impact player, but that’s his, his agent and his family’s decision right now. For us, we’re just trying to hold down the fort.”

domain: sports


The latest in the Lego Creator series is a classic Ferrari from the days of Jordache jeans, perms and Cyndi Lauper's debut.
As part of Road Trip 2015, CNET visits Mcity, a 32-acre fake city in Michigan designed to test self-driving cars' navigation and communication abilities -- and to keep research from migrating to Silicon Valley.
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It won't be long before we wonder how the world got along without solar and bio-based power, technology-enhanced vision and driverless electric cars.
"Many people told us it would be impossible."
Ex-Facebooker Bethanye Blount spent less than two months at Reddit before, she says, she realized that the social-news site's plans for the future may be unworkable.
The Xperia C5 Ultra and Xperia M5 include beefy megapixel cameras on both the front and back as Sony struggles in a highly competitive smartphone arena.
By building synthetic bacteria that can be taken in pill form, DARPA-funded researchers seek to keep our digestive systems in fighting form.
Ford Edge is nothing but better, except for one glaring exception in the middle of the dash.
Chevy's second-generation Volt RE-EV improves both its stated electric and gasoline-powered efficiency.


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text:
A new adaptation of Charles Dickens‚ unfinished novel, The Mystery of Edwin Drood, was given an ending. But should unfinished works be left untouched, asks Sarah Barclay at bbc.co.uk.
Depeschen mit dem Leitwort The Mystery of Edwin Drood
Möchten Sie Depeschen mit anderen Leitworten wählen?
„The Mystery of Edwin Drood, the tale of a missing boy and an opium-addicted choir master, was only half-written when its author, Charles Dickens, died. Now a dark new BBC drama imagines how it might have ended.“ Robert Douglas-Fairhurst reports at telegraph.co.uk.
„The Mystery of Edwin Drood, the tale of an opium-addicted choirmaster with an erotic obsession with his nephew’s teenage fiancée, is one of Charles Dickens‚ darkest and most modern novels.“ Gwyneth Hughes explains how she adapted a great literary whodunit for TV. Read the story at independent.co.uk.

domain: entertainment


Tata Nexon.ev facelift features revealed these advanced features will be available in the cabin
Tata Nexon.ev Facelift: The top model of Tata Nexon EV Facelift has a cinematic 12.30-inch touchscreen infotainment system. It has an app suite that allows users to access their favorite music videos and gaming apps. Take a look at the official TVC which details all the new features of the 2023 Tata Nexon EV.
Tata Nexon.ev facelift is set to launch in the Indian market on September 14. Before its official launch, the company released a TVC, in which all the features of this vehicle were revealed.
Nexon.ev is ready to set new trends with features like a 2-spoke backlit steering wheel, touch controls, an easy-to-grasp smart digital shifter, and a voice-assisted sunroof. Trims on offer include Creative, Fearless, and Empowered.
The top model of the Tata Nexon EV facelift has a cinematic 12.30-inch touchscreen infotainment system. It has an app suite that allows users to access their favorite music, video, and gaming apps. Take a look at the official TVC which details all the new features of the 2023 Tata Nexon EV.
Tata Motors has also introduced some interesting innovations like vehicle-to-vehicle reserve with Nexon.ev. The battery can also be used as a powerband to charge various devices and equipment. Other key features the company has included include a JBL Sign Electronics sound system, digital cockpit, embedded PSU, dealers charger, skateboarding auto and nominal CarPlay, air purifiers, electronic commerce brake, auto-dimming DRVM, and OTA updates.
This electric SUV has a Gen2 motor, which is now capable of running at 16,000 rpm, up from the earlier 12,000 rpm. The new motor produces 106.4 kW (142.6 bhp) and a maximum torque of 2,500 Nm at the wheel. Tata says it has increased the flat torque curve up to 750 rpm across the range for more consistent performance. This EV accelerates from 0-100 kmph in 8.9 seconds, while its top speed is pegged at 150 kmph, which was 120 kmph on the older version.
The new Tata Nexon EV medium range now comes with 7.2kWh charging, which was earlier exclusive to the Max variant. The company claims to get a full charge in 56 minutes with a fast charger. The model also gets V2L (vehicle to load) and V2V (vehicle to vehicle) charging, similar to what we have seen on the Hyundai Ioniq 5.


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At a gathering of Kentucky business leaders last year, an economist pulled up a list of the largest cities in Kentucky. Louisville (600,000), Lexington (308,000), Bowling Green (61,000), and Owensb
With Governor Bevin expected to call a special legislative session soon to pass his public pension plan, we are reminded of Henry Ford, who famously said his customers could have cars painted “any
Much of my misspent youth was shaped by Bob Dylan and Alfred E. Neuman.
The summer vacation season has arrived and tourism in Northern Kentucky has never been hotter.
Small talk with a colleague following a morning meeting at the office led to a topic which has become wildly uncomfortable in the American workplace: politics.
Thousands of Kentuckians live in areas known as “food deserts.”
Editor's note: The following letter was received for publication following the approval by the Kenton County Planning Commission of a 106-unit apartment deve
I’m a lifelong Kentuckian that’s been all over the state. I’ve been to Mammoth Cave and Carter Caves. Cave Run Lake and Lake Cumberland. The Louisville Slugger Museum and the Newport Aquarium.
I have been a U.S.
The epidemic of illegal drug abuse is one of the most difficult challenges facing our communities.
Did you know that over 6,000 young adults (ages 16-24) currently living in the eight counties of Northern Kentucky are not connected to employment or education?
David Keltz is a graduate student at New York University. He is pursuing a career in public relations. As part of his studies, Keltz examined the January incident in Washington, D.C.
When Notre Dame Cathedral burned on April 15, people across the world mourned the damage.

domain: sociology


Due to the popularity of A36 steel plate, steel plate suppliers like Leeco keep a healthy inventory of a wide variety of plate sizes, making it easy to source. A36 is also one of the most economically priced grades of steel plate. A36 Equivalent Plate Grades A36 steel is produced to meet standards set by ASTM, whose material standards are
ASTM A36 steel plate thickness tolerance steel plate,ASTM ASTM A36 steel plate is the most purchased hot rolled steel plate in the world and the least expensive of the commercial carbon steels. The heat ability reates very good welding properties, and the 36 ksi yield strength makes ASTM A36 steel plate acceptable for most applications. A36 is considered a mild steel due to its relatively moderate hardness.
ASTM A537 Class 1 Carbon Steel Plates vary from 0.4 mm to 80 mm in thickness and 1000 mm to 45000 mm width. Carbon Steel Plate used in various applications like Oil &
Checker Plate ASTM B209, ASTM A36 Thickness 2 - 12 mmMild steel checkered plate size length 2440 mm × width 220 mm × thickness 8 mm. Hot rolled mild steel checkered plates 3 mm, 4 mm, 6 mm × 1220 mm × 2440 mm. 1.2 mm thick AS2024 4T(D16T) checker sheet, anti skid button rivet, size 1220 mm × 2440 mm, 1500 mm × 3000 mm.
China 8mm Thick Base Plate, 8mm Thick Base Plate Design engineers or buyers might want to check out various 8mm Thick Base Plate factory & manufacturers, who offer lots of related choices such as steel plate, wear plate and wear steel plate. You can also customize 8mm Thick Base Plate orders from our OEM/ODM manufacturers. They are experienced China exporters for your online sourcing.
ASTM A36 Steel Plate, A36 Steel Plate, ASTM A36 manufacturer / supplier in China, offering ASTM A36 Mild Steel Plate, AISI ASTM GB 24crmo5 Round Bar Mild Carbon 50mm Steel Round Bar, Slotted Square Tube Steel Square 4130 Chromoly of Shs Square Steel Pipe 300X300X12.5 and so on.
High Quality, Reliable, Performing 8mm corten steel plate ASTM A36 Hot Rolled Carbon Steel Sheet / Steel Plate/MS Sheet A36 S235 S275 S355 8Mm Mild Prime Corten Hot Rolled Steel Plate $430.00-$550.00 / Ton 1.0 Tons (Min. Order)
MetalsDepot® - Buy A36 Steel Plate Online!A36 Steel Plate is one of the most popular hot rolled, low carbon steel plates used in manufacturing, fabrication, and repair projects.A36 Steel plate adds strength and rigidity to any project at a lower price compared to other grades of steel plate. It is easy to weld, cut, form and machine.
ASTM A36 Mild Steel Plates Suppliers:ASME IS 2062 GR.A Mild Steel Plate 2B Finish Dealer:Mild Steel ASTM A283 CR Plates Stockholder:Mild Steel IS 2062 GR.B Hot Rolled Plates Dealer:Mild Steel IS 2062 GR.A HR Plates:ASTM A283 Mild Steel Plates Exporter:ASTM A283 High Quality Mild Steel Plates:ASTM A36 Mild Steel Cold Drown Plates
Plate - McNeilus SteelPlate ASTM A36 ASTM A36 is a structural quality carbon steel for use in welded, bolted or riveted construction of bridges and buildings, and for general structural purposes. Minimum yield strength of 36 ksi (250 MPa) is required to meet the requirements of A36. ASTM A36 plate is used in a variety
Steel Plate Orrcon SteelOrrcon Steel structural steel hot rolled plates and checker plate are supplied in accordance with AS/NZS 3678 thickness ranging from 3mm to 100mm and 2.1mm to 6mm for checker plate.
Steel sheets and plates are typical stocked as size 2000 mm x 3000 mm. Weight per sq. meter of hot rolled mild steel plates can be calculated as. W = 7.85 t (2) where . W = weight of steel plate (kg/m 2) t = plate thickness (mm) Steel Plate Weight Calculator - Metric Units. width (mm) length (mm) thickness (mm) density (kg/m 3)
ms plate q235 carbon steel sheet steels- CBD Steelms plate astm a36, ms plate astm a36 Suppliers and ASTM A36 Q345 ms plate q235 25mm st52 thick mild carbon steel sheet steel plate name steel plate steel plate Specification Width 900-2500mm or 1000,1050,1250,1500,1800,2000mm Thickness:1.5mm-200mm Length:2-12m or as customers special requirements steel plate grade SS400, ASTM A36, A572, ST37,ST52, Q195, Q215, ASTM A36 Steel Plate Thickness & PriceASTM A36/A36M description This is a type of weldable carbon engineering structural steel. Its carbon content is usually less than 0.25%, higher than ordinary carbon structural steel yield point s or yield strength 0.2 (30 ~ 80kgf/mm2) and yield ratio s/b (0.65 ~ 0.95), its better in the hot and cold machinability, good weldability, low cold and brittle tendency, notch and aging


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NEW TODAY! Dave's Ice Cream, 3872 W. Main Street Road, Batavia, NY. Dave's offers only locally purchased products, including Perry's hard ice cream in a wide variety of yummy flavors, with a wonderful assortment of toppings and homemade waffle cones. Different soft-serve flavors are offered weekly. We have a $10 gift certificate for $5.
Alex's Place, 8322 Park Road, Batavia, NY: People come from all over the region for a fine dining experience at Alex's. It's best known for its ribs, of course, but Alex's seafood is also a favorite of the restaurant's diners. We have a $25 gift certificate for $12.50.
Alli's Cones & Dogs, 7063 Lewiston Road, Oakfield, NY: Full breakfast, lunch and dinner menu; all-you-can-eat salad bar; ice cream served year-round; eat-in or take-out. We have a $20 gift certificate for $10.
Bohn's Restaurant, 5256 Clinton St., Batavia, NY: Fine dining in an atmosphere of casual elegance. Lunch and dinner, steak, prime rib and seafood. Ask about Bohn's catering services and banquet facility. We have a $25 gift certificate for $12.50.
Bourbon & Burger Co., 9 Jackson St., Batavia, NY: Batavia's newest burger joint offers more than two dozen different types of tasty hamburgers. Our menu also includes a variety of sandwiches, appetizers and an extensive beer list, plus a full bar. We have a $20 gift certificate for $10.
The Color Salon, 35 Center St., Batavia, NY: Our attention to detail, combined with the focus on precision haircutting techniques will ensure that your hair will be your best accessory when you leave The Color Salon. We offer all hair care services including cuts, color, highlights, up-dos, as well as waxing services. We carry products such as KMS and Paul Mitchell. Now available: Bella Taylor purses! We have a $25 gift certificate for $12.50.
Daphne's Restaurant, 241 Swan St., (Off Rt. 63/Ellicott St.) Batavia, NY. Daphne's is destined to become a favorite for any who enjoy something special in a dining experience. Formerly the old St. Nick's Social Club, now unrecognizable to those who used to frequent the club, Daphne's provides you with a warm, inviting atmosphere and decor, which complements the array of wonderful dishes. We offer homemade seafood and pasta dishes, meatballs that are addicting as well as large salads, hot sandwiches & homemade potato chips. Fresh desserts are prepared in our own kitchen (tiramisu has been the top seller so far). We have a $20 gift certificate for $10.
The Enchanted Florist, 202 E. Main St., Batavia, NY: Whether you need just the right gift or a memorial or just want to brighten your own home or work place, The Enchanted Florist can put together just the right floral arrangement for you. We have a $20 gift certificate for $10.
Ficarella's Pizzeria, 21 Liberty St., Batavia, NY: Dine-in, drive-thru or delivery. Featuring fresh, hearth-baked pizza since 1985, plus wings, pasta and more. We have a $20 gift certificate for $10. (Good only at the Batavia location.)
Greg'ry's Bakery, 13 N. Lake Road, Bergen, NY: The bakery offers a variety of the finest cakes, cookies, pies, cupcakes, breads, breakfast and lunch sandwiches and so much more. Each treat is made the same as it has been for decades and baked right here. Come in and sample some for yourself! We have a $20 gift certificate for $10.
Salsa & Curry, 13 Jackson St., Batavia, NY: An authentic Mexican restaurant, offering all of your favorite dishes from enchiladas and burritos to tacos and fajitas, as well as daily Indian food specials. We have a $20 gift card for $10.
Santino's Pizza, 2 Main St., Oakfield, NY: We're pizza and a whole lot more! Voted #1 pizza in Genesee County in blind taste test! Santino's features pizza, wings, subs, wraps, ice cream, and more! We have a $20 gift certificate for $10.
Settler's, 353 W. Main St., Batavia, NY: Settler's has a 25-year history of serving great, affordable breakfasts, lunches and dinners to Batavians. We have a $20 gift certificate for $10.
Smokin' Eagle BBQ & Brew, 9 Main St., Le Roy, NY. The kind of downhome, laid-back and comfortable place that just feels right. Open daily for lunch, dinner and drinks, this eatery and bar features a variety of eats and drinks that are outstanding. Specializing in smoked meats -- each meat is dry rubbed with a proprietary mix of seasonings, then smoked slowly in their on-site smoker for maximum flavor and tenderness. With a variety of appetizers, burgers, sandwiches, wraps, combo platters and entrées, there's always plenty of choice for even picky eaters. Great food, frosty brews and some of the best folk around call the Smokin' Eagle BBQ & Brew their favorite -- make it your favorite today! Don't forget to ask about our catering! We have a $20 gift card for $10.
Viking Valhalla Restaurant & Rose Garden Bowl, 21 Buffalo Road, Bergen, NY: Open for lunch Monday through Sunday, and dinner Friday and Saturday evenings. Dinner favorites are our succulent prime rib and Friday fish fries! We are always happy to help plan your special occasion -- wedding, shower, rehearsal dinner, stag party, graduation, company function, banquet, family or class reunion. We have a $20 gift certificate for $10.
Sweet Ecstasy Bakery, 6173 Main Road, Stafford, NY. A retail and special order bakery located in Stafford. Offering a wide variety of items such as cookies, filled cupcakes, quick breads, pies, breakfast pastries, daily. On Fridays, Sweet Ecstasy Bakery offers fresh artisan bread like baguettes, sourdough and rye starting at noon. The custom cakes are out of this world with 3D characters or gorgeous wedding cakes to suit any budget. For all your sweet treats, we have a $10 gift certificate for $5.
Palm Island Indoor Water Park, 8250 Park Road, Batavia, NY: The newest family fun center in Genesee County, featuring a hot tub, monsoon lagoon pool and play area, tipping buckets, water slides, arcade with 15 games and birthday party rooms. We have a pair of gift certificates worth $40 in merchandise or services for $20.
Spirits, 78 Lake St., Le Roy, NY. Le Roy's favorite sports bar, where fun and good food are always on tap. Come try one of our many delicious burgers that we have to offer, as well as our HUGE Bomber Sandwich, homemade chicken fingers made to order, and the all-time favorite Dumpster Plate with many choices. We deliver. We have a $20 gift certificate for $10.

domain: food


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The breath is one of the most important tools for recovery. If you are stressed, you will often take short, sharp breaths. This is no good for your body and is certainly no good for athletes. Take some time every day to relax and focus on your breath (even if just for 30 seconds).
As a student athlete you need to be able to balance schoolwork with training and competing in your sport. Breath work can help slow things down and reduce the stress that comes with a tough schedule.

domain: health


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Manhunt for Suspect Underway After Dismembered Body Found in Plastic Bags in Yard of Georgia Home.
Georgia's Bureau of Investigations are looking for a suspect after they say a dismembered body was found in the front yard of a small town home.
Hancock County Police received a call around 7pm on May 4th stating that there was a dead body in the yard of a home on Main Street. When they arrived they did confirm that there was a deceased person. At this moment they do not know how long the person has been dead and they are not identifying the victim's identity. Authorities have said that they have a person of interest in the case.
A law enforcement source familiar with the investigation told the newspaper that the body had been placed “in plastic bags” and may have been dismembered.
The city of Devereux is a tiny community of about 1,400 people located southeast of Atlanta, roughly halfway between Macon and Augusta.
Anyone that has information can call the GBI’s regional investigative office in Milledgeville at 478-445-4173 or the Hancock County Sheriff’s office at 706-444-6471. Tips can also be submitted by calling 1-800-597-TIPS(8477), online at https://gbi.georgia.gov/submit-tips-online, or by downloading the See Something, Send Something mobile app.

domain: law


Children being sold like commodities – does that really happen in the 21st century?
What seems unimaginable is, however, a bitter reality for millions of girls and boys all over the world. They are the victims of an unscrupulous but profitable business that meets an international demand. Trafficking children is a free market in its most brutal form, a billion-dollar business for those pulling the strings in the background and those who exploit the victims.
Child trafficking is a crime known the world over and that stops at no borders. Girls and boys are sold to be used as cheap labor, prostitutes or thieves, beggars or drug couriers. Babies are also traded for commercial adoptions and girls for arranged marriages. Frequently the children of impoverished parents (or their parents) are attracted by false promises of training or good earnings, since they generally lack money and any prospect of a good life.
In March 2008, a boy from Bangladesh was brought to India under the false assumption that he would be the cook for a family. In the hope of being able to contribute financially to his family, the fourteen year old boy was unknowingly brought to Delhi by a trafficker with the intention of pushing him into committing illegal activities, more specifically theft and murder. The boy was later apprehended by the police in Delhi for administering a poisonous substance in the food he had prepared for the family. Although the boy acknowledged the kindness of his employer and admitted to the charges that were laid against him, he was vulnerable and a victim of his compelling circumstances. The trafficker had threatened the boy that he would never go back and see his family again. The pressured boy felt he could do nothing but commit this heinous crime.
For traffickers, human life is an object that is a means to facilitate their objectives. The cruelty and lack of compassion for human life is evident in the case illustrated above. Even after the boy handed over the stolen goods such as gold and jewellery, the trafficker was infuriated at the boy for not stealing enough. The teenager was summoned and returned back to Bangladesh. Thankfully, the trafficker later had charges laid against him.
Human trafficking in India, whereby children are traded for criminal acts, points to organized trafficking gangs. Children are not only used as slaves, but are also being used as modern day criminals to inflict violence on others, particularly their domestic employers, for theft and robbery- an issue that has not often drawn public attention as of yet.
Another somewhat similar crime was reported in Lucknow in 2008 where a woman in her seventies and her family, along with two young women, were killed and later robbed by their domestic helpers. This case and many more that have been brought before the Juvenile justice Boards (JJBs) deal with vulnerable children who are deceived and recruited by people in authority, with the false pretense that they will work as domestic labors. The children are embraced by their traffickers and then forced to harm their employers.
The degree of the demeaning acts that traffickers force these innocent children into doing is shocking and difficult to process. There can be no monetary value on human life. So when one asks what the reason for all this human degradation is, they are most likely left with a simple answer: “it is for the purpose of monetary benefit.”
One may place the blame on the child for not approaching the authorities or the family that he is being compelled to hurt. One may also assume that the child may do such an act for his own monetary benefit. However, when a child is exploited in vulnerable circumstances and has not developed vital (and essential) mental and physical maturity, he is unable to process his way out of the exploitative situation.
Such trafficked children have been first produced before the Juvenile Justice Boards, where adjudication and subsequent rehabilitation are handled. However, several child right activists and lawyers have expressed their concerns for the appropriate authority to deal with these cases.
According to the National Crime Record Bureau, 32,681 juveniles are arrested by police every year in India on charges of murder, rape, dacoity, robbery, burglary, theft, hurt and other crimes. Six percent of them are girls. Juvenile delinquency has increased by 1.1 per lakh of population in 1995 to 1.7 per lakh of population in 2008. Poverty and illiteracy were the two main causative factors behind this. In all, 27 per cent of the arrested juveniles were illiterate, 37 per cent under primary, 72 per cent from the BPL families, 6.8 per cent from the middle income group and 0.2 per cent from the high income group. The ill-effects of juvenile delinquency can be mitigated if the fundamental principles for the administration of juvenile justice are put into practice.
Even if the JJBs continue to take care of such children, the crucial question that arises is whether these authorities should bring adult traffickers to justice or not?
The amended Juvenile Justice (Care and Protection) Act empowers the Juvenile Justice Boards to take cognizance of acts of cruelty against children. Yet, neither the police nor the Boards have bothered to look into the involvement of organized groups or non- organized individuals. It is essential for the authorities to prepare social investigation reports (SIRs) and social background reports (SBRs) of children involved in such cases to assess the quantum of child abuse. In cases wherein SIRs and SBRs confirm the role of adults, it is imperative for the JJBs to act against such adults so that no child is exploited for his/her vulnerability and then be punished for it in the future.
Hence, it can be concluded that trafficking in human beings, especially children, is a form of modern day slavery and requires a holistic, multi-sectoral approach to address the complex dimension of the problem. It is a problem that violates the rights and dignity of the victims and therefore requires, essentially, a child’s rights perspective while working on its eradication. In the fight against trafficking, government organizations, non- governmental organizations, civil society, pressure groups and international bodies; all have to play an important role. Law cannot be the only instrument to take care of all problems.
Ministry of Women and Child Development, Govt. of India, www.wcd.nic.in
The writer is a correspondent at Youth Ki Awaaz.


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Bubbly Wine Tour
As we are in Marlborough, the largest wine region in New Zealand, with 27,000 Hectares, we thought it best that we do a wine tour! Well, what an indulgement! We enjoyed going to 6 different vineyards all transported by our lovely host Kathy, who did a great job of keeping up the conversations and making us all laugh! We were on tour with 4 other lovely people, one from France and 3 from England (and turns out they used to live in Wendover too!).
|Frankie (the dog) enjoying the wine tasting with us!|
|The lovely view over Brancott Estate|
|Enjoying the Pinot Gris|


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After the study of brain tissue from two patients with symptoms such as sleep disorders REM and non-REM behavior, movement and breathing disorders (obstructive apnea), the researchers identified the presence of an antibody against a neuronal protein, IgLON5, responsible for the neurodegenerative process linked to the autoimmune process.
The results allow to diagnose disease was not known so far, and suggest the possibility of a future control inflammatory processes that control turn neurodegeneration in these patients.
Lidia Sabater, Carles Gaig, Ellen Gelpi, Luis Bataller, Jan Lewerenz, Estefanía Torres-Vega, Angeles Contreras, Bruno Giometto, Yaroslau Compta, Cristina Embid, Isabel Vilaseca, Alex Iranzo, Joan Santamaría, Josep Dalmau, Francesc Graus. A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. The Lancet Neurology, Early Online Publication,3 April 2014. doi:10.1016/S1474-4422(14)70051-1

domain: medical


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Lippes Mathias Wexler Friedman LLP Chairman Scott E. Friedman Named to Buffalo Business First Power 250
February 27, 2019 | Press Releases
BUFFALO, NY – Scott E. Friedman, chairman at Lippes Mathias Wexler Friedman LLP, has been named to Buffalo Business First’s Power 250, ranking #154. This list ranks Western New York’s 250 most influential business leaders to watch in 2019 as selected by a committee of the publication’s editors and reporters.
At Lippes Mathias, Mr. Friedman also serves as the firm’s Family Business Practice Team leader. In addition, he is a general partner in Impact Capital of New York, LLC, a venture capital fund, and a principal and senior advisor in Delphi21 Advisors, LLC, a business advisory firm.
2020 Upstate New York Super Lawyers Recognizes 36 Attorneys from Lippes Mathias Wexler Friedman LLP
August 21, 2020
The Best Lawyers in America® 2021 Edition Includes 28 Lippes Mathias Wexler Friedman LLP Attorneys
August 20, 2020
In The news
Scott E. Friedman and Andrea H. Vossler featured in Buffalo Business First article "Will startup funding dry up in Buffalo? Local investors weigh in"
April 5, 2020


Ellen from Tryon writes
My mistake. I planted asparagus sets on a patch that had been treated. How many years before it will be safe to eat the asparagus? Also, how long before I could grow tomatoes on treated ground.
We advise to wait at least two years after application of Prodiamine 65 WDG (Generic Barricade to plant edibles.
Answer last updated on: 05/25/2016


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Think remote monitoring, control and analysis of pump systems. Think reducing water losses via Web Based IIOT technology.
Think of connecting field instruments to IoT for predictive maintenance. Think of using an Advanced Planning & Scheduling (APS) software tool as a replacement to Materials Requirements Planning (MRP) within a valve manufacturing company.
All the above mentioned scenarios and more will feature in free-to-attend workshops, conference sessions and a stakeholder engagement forum as part of the Pumps, Valves & Pipes Africa 2019 expo and conference taking place 11-13 June at Gallagher Convention Centre in Midrand, Johannesburg.
Co-located with African Construction Expo and Totally Concrete Expo, the event will address the impact of the 4IR and the way we view traditional, local sectors of the economy that are involved in the conveyance of liquids, gases & slurries.
The Fourth Industrial Revolution (4IR) encompasses the Internet of Things, but goes beyond simple device connectivity toward being an ‘Internet of Everything’.
At its core is the combination of big data, analytics and physical technology. It’s the collective force behind many products and services that are fast becoming indispensable to modern life.
According to Content and Marketing Project Manager, Nico Loretz, a high-level panel discussion will look at how the 4IR will affect the mind shifts in the way we view traditional and local sectors of the economy.
He continues: “The growing focus towards industrial expansion with the petrochemical-, power-, mining- water- and growing food and beverage sectors will drive demand for industrial pumps, valves and pipes for years to come.”
According to a published TechSci Research report “Africa Industrial Valves Market By Type, By End User, By Country, Competition Forecast and Opportunities, 2011 – 2021”, that the industrial valves market in Africa is forecast to surpass $4 billion by 2021.
And according to Frost & Sullivan, the global centrifugal pumps’ market revenue is expected to grow at a compound annual growth rate of 2.5% and reach $28.57bn by 2023.
Loretz says presentations and case studies related to the 4IR will be delivered by AngloGold Ashanti, Franklin Electric SA, Society for Automation, Instrumentation, Measurement and Control (SAIMC), nCoded Solutions and others.
Apart from the free-to-attend conference, the event will feature exhibitions from leading manufacturers, equipment- and service providers. Visitors will be able to meet face to face with a network of new suppliers of pumps, valves, pipes and components and will be able to assess the latest products and innovations.
Entrance to the expo, workshops and conference is free. Visitors are requested to register and activate their free visitor passes online at www.pumpsvalvesandpipesafrica.com or contact the team at +27 11 783 7250.
Event dates and location:
Date: 11 – 13 June 2019
Location: Gallagher Convention Centre, Johannesburg, South Africa
Event website: www.pumpsvalvesandpipesafrica.com


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What challenges are gene therapy developers facing today?
The use of viruses as cell and gene therapy vectors is complex, and in this fast-moving field there is no playbook to help you develop methods and safely scale-up products and processes.
Do you recognize these challenges?
- Establishing a fit-for-purpose analytical toolset to identify and validate the critical quality attributes of complex proteins
- Identifying and implementing appropriate methods that generate the data needed to ensure the safety, potency, and purity of viral vectors
- Keeping up to date with the latest technology and approaches, while quickly repurposing existing tools and processes
- Staying compliant with constantly evolving regulatory guidelines that vary from country to country
- Finding the efficiencies, people, and resources to develop innovative products and processes
- Overcoming the hurdles associated with complex tasks, such as capsid design, quality control and process optimization
- Successfully transferring new discoveries to scale-up and manufacturing
Malvern Panalytical can help
Malvern Panalytical provides more than world-leading instrumentation.
Developing viral vectors requires fit-for-purpose tools and the know-how to apply them to generate the data you need. With years of experience supporting customers in the development of gene therapy products, our application scientists have the knowledge to help you access breakthrough insights from your analytical toolbox.
Work with us to overcome your gene therapy challenges:
- Utilize fit-for-purpose analytical instrumentation that identifies multiple critical quality attributes and delivers efficient and compliant methods
- Discover tools to characterize viral titer, empty/full ratio, aggregation content and batch-to-batch consistency via an orthogonal approach to analytics across multiple vectors
- Quickly realize the full value of your investment in analytical technology with training and support for your team
- With unrivaled experience in the use of advanced instrumentation for gene therapy applications, our scientists can act as a flexible extension to your team
- We provide method development services to overcome your specific challenges
- We help you develop reliable, repeatable techniques that improve the efficiency of your workflows
We’re ready to apply a combination of analytical instrumentation and years of experience to provide flexible support, wherever and whenever you need it – to drive forward the therapies of the future.
Are you ready to overcome your challenges?
Whatever characterization challenges you are facing, chances are we’ve worked with a team just like yours and helped them implement the technology and methods needed to make safe and effective drug products faster.
To find out how our team of experts can accelerate the development of your next product and speed up your journey to market, contact us today.
|Gene therapy development
|Viral capsid design
|From capsid design, through to the optimization of downstream process conditions. From formulation and stability tests to the extended characterization of drug substances and drug products.
|Comprehensive physicochemical, biochemical and biological data provide insights on the performance of viral vectors, helping with the selection of the optimal viral capsid.
|The gene therapy production process must meet strict regulatory requirements and other internal expectations for quality, timelines and costs - which calls for fit-for-purpose solutions and specialist expertise.
Since we purchased OMNISEC, we’re able to deliver more sensitive data, so our ability to support decisions has been directly enhanced. In an analytical lab like ours that operates so many techniques with relatively few people, improving productivity is a major gain.
Gene therapy development
From capsid design, through the optimization of downstream process conditions, to formulation and stability tests and the extended characterization of drug substances and drug products, technologies such as Dynamic Light Scattering (DLS), Electrophoretic Light Scattering (ELS), Multi-Angle Dynamic Light Scattering (MADLS), Size Exclusion Chromatography-Multi-Angle Light Scattering (SEC-MALS), Nanoparticle Tracking Analysis (NTA), Grating-Coupled Interferometry (GCI), Isothermal Titration Calorimetry (ITC) and Differential Scanning Calorimetry (DSC) are used to inform scientists on the key analytical and quality attributes of viral vectors, enabling characterization, comparison and optimization of:
- Capsid size (DLS, SEC, NTA)
- Capsid titer or particle count (MADLS, SEC, NTA)
- Percentage of genome-containing virus particles / % full analysis (SEC)
- Aggregate formation (DLS, MADLS, SEC, NTA)
- Fragmentation (SEC)
- Thermal stability (DLS, DSC)
- Higher-order structure analysis (DSC)
- Serotype identification (DSC)
- Capsid uncoating and genome ejection (DLS and DSC)
- Binding to receptor (ITC and GCI)
- Charge (ELS)
DLS, MADLS, SEC-MALS, NTA, GCI, ITC, and DSC are label-free quantification techniques which require minimal assay development and can be readily applied at all stages, strengthening the analytical workflow for gene therapy development.
Viral capsid design – research & early development
Although the discovery process for gene therapy is shorter than that typically seen in traditional drug discovery, the high degree of product complexity introduces additional challenges which must be addressed early-on to assure the delivery of safe and efficacious products. Amongst these challenges are:
- Selection of a viral capsid based on optimal properties and function
- Rational protein engineering to improve and modify the properties and functionalities of the original viral capsid
The solutions in both cases are based upon a comprehensive set of physicochemical, biochemical, and biological data which informs on the performance of the viral vector and feeds back on the selection process.
At this stage, extensive biophysical characterization of engineered capsids and viral vectors using DLS, MADLS, SEC-MALS, ITC, and DSC supports the reliable evaluation of important quality metrics and interpretation of the results of biochemical and biological assays, via measurements of capsid size and titer, aggregate formation, % full measurement, receptor binding, thermal stability and capsid uncoating propensity.


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2 Bedroom Suite
Ritz Carlton - St. Thomas
2 Bedroom Suite Includes:
King Master Suite with Master Bath
2 Queen Beds & Adjacent Bath in 2nd Bedroom
Queen Sleeper Sofa in Living Room
1550 Square ft. Condo, 500 Square ft. Balcony
St. Thomas Vacation Rentals Benefits
The fully equipped bistro-style kitchen offers superior dining convenience. Contact your dedicated concierge for pre-arrival fridge stocking. These St. Thomas vacation rentals also feature ocean views of St. Thomas’s beautiful Great Bay.
Ritz Carlton St. Thomas Resort
Enjoy an exclusive location on the island's picturesque Great Bay. The private property offers Ritz Carlton St. Thomas Hotel and Club guests the opportunity to enjoy pristine, white sand beaches and fun water activities. Water sports equipment is available for an additional resort fee. Fine dining, pools, spa and fitness center are also available throughout the resort.
Explore this fun filled island, where you will find shopping in Charlotte Amalie, world renowned snorkeling at St. John’s Trunk Bay, and the famous Baths of Virgin Gorda nearby. The Ritz Carlton St. Thomas staff can help you make arrangements for Caribbean adventures.

domain: travel


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As part of National Homelessness Week this week (7-13 August 2023), we are sharing Kym’s story. Kym is just one of hundreds of clients being supported to take their first steps out of homelessness, through the Toward Home Alliance.
“I’ve always struggled with asking for help, but I said to myself, ‘I have to do this for my child’.”
This was the promise of single father Kym, who sought support after he and his child were forced into homelessness due to the current rental crisis.
When Kym learned his rental lease of six years was not going to be renewed, he immediately began the hard slog of searching and applying for houses around his local community in Adelaide’s south.
With his neurodiverse and anxious child struggling to stay connected to their education, it was important to find secure and safe housing as soon as possible, close to school and other supports. But, finding an affordable rental was proving impossible. Initially, each application brought hope and excitement, but following rejection after rejection, Kym found himself facing homelessness for the second time in his life.
“I had been applying for six months beforehand because we knew we had to find somewhere,” Kym says.
“When the lease ran out, I was able to stay with friends for a couple of months, but then because they were renting as well and their landlord was unhappy with having extra people there, we couldn’t stay too long.
“My original plan was to move in with a friend, but we just weren’t having any luck with the rentals we applied for.”
The first time Kym fell into homelessness was not long after his child was born. At the time, he and his former partner stayed with friends for a month, before finding an affordable property.
This time, however, the search for a rental was much more difficult.
Record-low vacancy rates across the country have created a gaping power imbalance between landlords and tenants. According to Domain, all capital cities in Australia hit record highs for advertised house rents earlier this year and it’s not just those on the rental hunt who are feeling it. Australians already in tenancies are reporting widespread rental increases, often in excess of $100 a week. Being unemployed was another barrier to success in Kym’s search.
Needing assistance urgently, Kym connected with the Toward Home Alliance, a Lutheran Care-led network of experienced providers offering services to people experiencing and at risk of homelessness in Adelaide’s CBD, inner and outer southern metro area and the Adelaide Hills.
“We just had nowhere else we could go, so I got in touch with Toward Home to see what they could help me with,” Kym says.
“After that, my caseworker from Lutheran Care advocated for us to have Emergency Accommodation in a motel and that came through pretty quickly down at Maslin’s [Beach].
“We appreciated staying with the friends that we were with, but my child has recently been diagnosed with autism and they have two younger children, which made it very difficult for my not very social child.
“So it was good to have our own space.”
Kym and his child stayed in Emergency Accommodation from February to April this year. When a place close by became available through Junction, Toward Home staff helped the family secure the tenancy.
“We were told we can stay here anywhere between three to 18 months,” Kym says.
“We’ve already been here just over the three now because we had the lease extended until October.
“It’s been really good. The motel was great to have somewhere to be while we needed it, but because we were in the same room, my child and I now have space from each other.
“And because our stuff was in storage for so long, it’s nice to have our stuff again.”
Having stable housing also drives routine and Kym says having a more predictable schedule has been helpful for both him and his child.
“There’s still some other stuff going on for me, with my mental health, but not having to worry about the house at the moment has taken a huge weight off,” Kym says.
Kym’s child is now more connected with their education and attending school more regularly.
“We’re only about five minutes away from the school now, so that is a lot more helpful. It’s been a lot more successful these last few months of getting them to go to school than we had for most of the last year.”
With the goal to secure his own rental at the forefront of his mind, Kym says he hopes to continue making progress and find employment in the next year as well. However, he is concerned that if rental vacancy rates across Adelaide don’t increase, it will make this more challenging.
“Being unemployed doesn’t help with how much I can afford for rent,” Kym says.
“Hopefully we can find somewhere.”
Kym feels confident both Junction and Toward Home will be there to support the family again if they need it.
His advice to others who are struggling to find a rental right now is to reach out for help, though he acknowledges this can be difficult for some.
“The thing that I struggled with was actually just asking for help,” Kym says.
“Don’t feel like you shouldn’t and feel like you’re being a burden for doing it, because if you need the help, you need the help.”


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52 Pretty Pics Of Family Signs for Home
– Glad to meet you, in this particular time period I am going to show you relating family signs for home.
best 25 family signs ideas on pinterest find and save ideas about family signs on pinterest family signs wood signs for the home clever or inspirational spiritual or romantic our collection of decorative wood signs has just the sentiment perfect for family and friends a wooden sign for the home can be the perfect design touch to pliment a variety of decors including shabby chic rustic or modern the quotation possibilities make wood signs even more versatile amazon family signs home & kitchen line shopping from a great selection at home & kitchen store personalized family name signs shop american woodcrafts for high quality personalized wooden signs established signs family name signs decorative woods signs and much more family sign find great deals on ebay for family sign in home signs and plaques shop with confidence family signs home family signs operates on a fall and spring semester system 14 weeks semester and sometimes summer equipment and high speed internet there is no cost to participate in the family signs program however students and instructors are expected to have puters with webcams and high speed internet best 25 family established sign ideas on pinterest find and save ideas about family established sign on pinterest wooden family name signs shop our extensive collection of personalized wooden family name signs perfect as wedding presents house warming ts and realtor closing ts family name sign home made interest this family name sign is simple to make using scrap wood and vinyl note this post contains affiliate links this means if you click on something and thefunnysign thefunnysign has a wide range of funny and humorous signs and home décor items for sale tickle your funny bone today with one of our hilarious signs
Love sign from family signs for home , source:www.etsy.com
17 Best ideas about Established Sign on Pinterest from family signs for home , source:www.pinterest.com

domain: design


The Austrian government is about to introduce a new fiscal management framework. The first step is to introduce a medium-term budgetary framework, including an expenditure rule. The paper focuses on this first step. The purpose is to describe and evaluate the Austrian model in light of other countries' experiences with their frameworks. An attempt is made to identify features that have proven to be effective elsewhere and that can be applied to the Austrian case. The paper also identifies potential challenges and possible trade-offs when implementing the framework.


Hyundai HYM3200E Corded Electric 1000W/240V Rotary Lawnmower
- Reviews (11)
The HYM3200E is a very versatile corded electric lawnmower with a robust and lightweight plastic chassis. Fitted with a 10 metre long reach power cable with 13amp 3 pin UK plug the HYM3200E is the ideal electric lawnmower for small to medium-sized gardens.
The HYM3200E electric mower is powered by a 1000w maintenance-free, brushless long-life motor. Brushless motors are maintenance-free and designed to offer many years of trouble-free use. Lower quality mowers use a less efficient and higher maintenance brushed motor.
With a cutting width of 320mm, The HYM3200E is ideal for small to medium-sized lawns up to approx. 144sq metres, 12m x 12m. Featuring a spacious quick release 25L grass catcher with a hard lid the handy grass collector ensures you'll spend less time emptying the cuttings and more time mowing.
The convenient grass level indicator on the top of the grass catcher will always inform you when the grass catcher is ready to be emptied and attaching and removing the collection bag couldn’t be simpler.
Changing the cutting height could not be simpler using the single 6 position lever and with six cutting heights, ranging from 20mm for a smooth lawn to 70mm for cutting longer grass, the HYM3200E puts you in control over the finish of your cut.
Operating this mower is a breeze too, simply press the safety button and pull back the Operator Presence Control lever and away you go! Weighing in at a measly 8.8kg you'll find this ultra-lightweight mower easy to push around your garden - essential for hand push models to minimise fatigue and maximise manoeuvrability.
The handles are adjustable for height and also fold down over the main power unit making this compact lawn mower easy to carry and store in a garden shed, garage and to transport in the boot of your car.
It’s quick and easy to assemble out of the box, allowing you to get it in your garden for the first cut in no time at all. With no engine to service, you also don’t need to spend time checking oil, air filters or spark plugs, making it extremely easy to maintain.
Features and Benefits
- Ultra-lightweight – Made from robust rust-free plastic chassis, weighing just 8.8kg.
- Quick and easy to use – Quick assemble, with foldable handles and a 25L grass collector bag minimises the time you spend emptying the cuttings.
- Ideal for small to medium gardens – 320mm cutting width makes it suitable for lawns up to approx. 12m x 12m.
- Battery Voltage: 230 - 240V~50Hz
- Cutting Heights: 20 - 70mm (6 Positions)
- Grass Catcher Volume: 25L
- Net Weight: 8.8Kg
- No Load Speed: 3450/min
- Electric Cable: 10M
- Motor Rated Power: 1000W
- Covered by Hyundai 3 year warranty
- Dimensions: D 110 x W 32 x H 101 cm
- Colour: Blue
- HYM3800E Electric Lawnmower
- 45L Hard Top Grass Collector
- User Manual
Vendor Direct Products:
This product is delivered by our approved supplier on a Standard Delivery Service.
Please be aware that we currently cannot arrange for delivery of this product to the following postcodes: AB, FK, HS, IV, KA, KW, PA, PH, ZE, LL58-LL78, IM, TR, BT, PO30-41.
In the UK you have a legal right, under the Consumer Contracts Regulations June 2014, to cancel your order within fourteen (14) days following your receipt of the goods. Refunds for orders cancelled under the provisions of the Consumer Contracts Regulations will be processed in accordance with your legal rights.
You may not cancel orders for the following types of products:
- Electrical/Technical products which have been unsealed
- Customised or bespoke Products
- Anything of a nature that for hygiene or associated health and safety - this includes the Outdoor Spas, Mattresses and Divan Sets
- Fresh food
Under the Consumer Contracts Regulations June 2014 you have a duty to take reasonable care of Products whilst they are in your possession. You will receive a full refund of the purchase price of the Products.
This is not intended to be a full statement of your rights under the Consumer Contracts Regulations. Full details of your rights are available from your Local Authority’s Trading Standards Office.
How To Return A Product
If you wish to return your item to Robert Dyas, you can do so by the following method:
1. Request a Collection via Robert Dyas Customer Services
Contact our Customer Services team on 0333 103 6677 (Monday- Friday 08:00 - 19:00, Saturday & Sunday 09:00 - 17:00, Closed Bank holidays. - call charges may vary by network) or via email to: firstname.lastname@example.org who will be able to arrange a collection for your item with the supplier. Please ensure that you provide your order number when contacting customer services.
If you are returning the item under your 14 day right to cancel, then a collection charge will be applied:
- Products < 20kg: £7.50
- Products > 20kg: £30
If you are not at home when we try to collect we reserve the right to deduct from your refund or charge your credit card the direct costs to us of the failed return in accordance with the Consumer Protection (Distance Selling) Regulations 2000.


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This Zhenyi Grsaed Ionic Membrane Kit Multifunctional Box Space the gallery form Wondrous Breathable Pillow. Hopefully you can find the best inspiration from our gallery here.


Grow Pittsburgh and Big Green (formerly The Kitchen Community) previously partnered to bring schools Learning Gardens, ADA accessible outdoor classrooms built to fit organically into any school yard. They are designed to be easily managed spaces which schools take ownership over and incorporate into the structure and culture of their school community. The Learning Garden transforms urban schoolyards into vibrant gathering places bursting with life.
We recognize that each school and community is unique, which is why we design each Learning Garden specifically for each school. Additionally, we pair the school with a talented Grow Pittsburgh Garden Educator for two years. Their job is to support teachers’ use of the Learning Garden as a teaching tool, and to help schools build the groundwork for a thriving garden in the years to come.


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Have you ever insulted your child? Has your child suffered from name calling? Have you ever thought how this could cause a great mental harm to your child? Verbal abuse should not be taken lightly. This happens more with mothers than fathers. I believe after reading the article below , you will never do it again! You can as well watch the video below.
Daisy was a grade three child. She was a quiet girl who did her work silently. She wasn’t social and most of the time she spent all alone. Let me say that she wasn’t gifted in class work. She lived with her mother who didn’t understand her at all. Most of the time is when she scolded her calling her names like cow, dog, donkey, foolish and stupid.
There was this one name she liked calling her mostly, “Ng’ombe” meaning cow. Anytime she did something wrong, she would shout at her,” Ng’ombe!”
One day , while at school, they were asked to do a quiz which she got nothing.The teacher was so annoyed as she thought the quiz was easy for everyone in class. So she shouted at her,” Kwa nini unafanya kama ng’ombe? ” meaning, ” Why are you behaving like a cow?”
Daisy walked to her desk feeling devastated. She was afraid of becoming the laughing stock of the class. Having reached where she usually sat, she covered her face using her sweater and cried bitterly.
It was during the creative lesson one afternoon when the teacher issued the learners with plain papers. Then she told them, ” On this paper, draw anything you may think of. Make your picture as attractive as you can.”
Every learner was excited to have the lesson. They enjoyed the creative writing and after some time the teacher collected the papers for analysis.
When she was going through the work, she came across this one paper. On it, a cow with a human head was drawn! To her amazement, the paper belonged to Daisy. Before the class could leave for break, she requested Daisy to be left behind.
” Why did you draw such an animal? I haven’t seen such a creature!” she asked Daisy. Daisy looked at her and started crying. It took a long time before the teacher could convince her to talk. Finally, she was ready to let it out.
” My mother always calls me a cow anytime I do a mistake. I have never known I am one until you asked me why I was behaving like one! When you asked as to draw, I tried to imagine how I looked like in the eyes of my mother and that’s what I came out with.” she narrated.
The teacher was very sorry and remorseful. She apologized to Daisy and after some talk with her, she decided to invite the mother to come to school where they talked at length about the issue. They swallowed their pride by apologizing to Daisy and promised that it wouldn’t happen again.
This was the beginning of a new Daisy! Everything seemed to change beyond expectations. Her performance improved as her self esteem too. She became the peer leader in upper classes and participated in most of the school activities. What a good ending!
From the above we can all see what insults and verbal abuse can do to our children. Let’s all refrain from calling our children names, insulting and scolding unnecessarily. This may cause mental challenges in our children leaving them stressed. As we discipline and make them responsible , it is always good to use kind words. We should avoid damaging their self esteem as this may bring a great harm to their lives.
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domain: literature