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Shrimp Tacos with Best Shrimp Taco Sauce (VIDEO)
These Shrimp Tacos are loaded with plump juicy shrimp, crisp cabbage, avocado, cotija cheese, cilantro and an easy shrimp taco sauce that will win you over. They are served over toasted corn tortillas so they are naturally gluten-free.
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What makes these Shrimp Tacos is the mouthwatering Shrimp Taco Sauce! This is the same sauce we use on our famous Fish Tacos and it’s mesmerizing. These tacos are an easy 30-minute meal that comes together fast. Taco night will never be the same!
Watch How to Make Shrimp Tacos:
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Ingredients for Shrimp Tacos:
- Shrimp – We used large 21-25 count shrimp, but the medium (26-30 count) or even small shrimp (31-35 count) would work well. Keep in mind smaller shrimp will cook faster.
- Red Cabbage – the color and flavor is perfect for tacos, but you can sub with green cabbage or even a coleslaw blend
- Cheese – Cotija is a Mexican cheese that is the traditional cheese for Mexican tacos. I found cotija at the grocery store next to the refrigerated tortillas.
- Toppings – avocado, red onion, and cilantro are our go-to toppings for tacos.
The Best Tortillas for Shrimp Tacos:
- Corn tortillas are best for making shrimp tacos. Either yellow or white corn tortillas will do but we love the flavor and texture of white corn tortillas best. Also, corn tortillas are naturally gluten-free which is always appreciated by those with food sensitivities.
- Flour tortillas will work if that is what you have on hand, but corn tortillas are the traditional and more authentic choice for Mexican tacos.
Our Go-To Shrimp Taco Sauce:
We use an easy garlic-lime crema with just a touch of spice from the hot sauce. If you love spicy shrimp tacos, add more sriracha hot sauce to taste. If you like it mild, add less hot sauce.
Serve this with a spoon or transfer to a zip bag to drizzle, but serving it out of a squeeze bottle makes it feel like dining out.
How to Toast Tortillas for Tacos:
- Over a Gas Stove Flame – We love this method for authentic lightly charred edges. Toast the tortilla directly over a medium/low open flame on a gas stove. Use tongs to rotate the tortilla about every 5 seconds. Flip as soon as the tortilla is lightly blackened on the edges and repeat with the second side. Keep your eye on that tortilla and adjust the flame as needed because they can burn quickly.
- On a Griddle – This is our favorite way to make a bunch of tortillas at once. Preheat a dry griddle to medium/high heat. Add tortillas in a single layer and toast 15-30 seconds per side until golden brown in some spots on each side.
- On a Skillet (preferably cast iron)- Heat a large skillet over medium-high heat. Add tortillas in a single layer (a very large pan can accommodate up to 3 at a time) and toast 15-30 seconds on each side until golden and hot on each side.
Keep these Shrimp Tacos in mind for your next Taco Night and make a taco bar out of it.
Love Tacos? Try these Taco Recipes Next:
- Fish Tacos – our #1 recipe for 3 years in a row
- Ground Beef Tacos – easy peasy and so juicy
- Slow Cooker Chicken Tacos – with tender shredded chicken
- Beef Bulgogi Tacos – Korean beef tacos
Shrimp Tacos with Best Shrimp Taco Sauce
For the Shrimp:
Shrimp Taco Toppings:
- 8 white corn tortillas, (small, 6” diameter), or Hard Taco Shells
- 1/2 small purple cabbage, 2 cups shredded
- 1 large avocado, pitted, peeled and diced
- 1/2 red onion, diced
- 4 oz Cotija cheese, (1 cup grated on a box grater)
- 1/4 bunch cilantro, coarsely chopped
- 1 lime , cut into 8 wedges
Shrimp Taco Sauce Ingredients:
- 1/3 cup sour cream
- 1/3 cup mayonnaise
- 1 1/2 Tbsp lime juice, squeezed from 1 medium lime
- 3/4 tsp garlic powder
- 3/4 tsp Sriracha sauce, or to taste
Thaw and pat dry shrimp with paper towels and place in a medium bowl. Add seasonings and garlic and stir to combine.
Place a large non-stick pan over medium-high heat. Add 1 Tbsp olive oil and add shrimp in a single layer. Sauté 1-2 minutes per side or just until cooked through. As soon as they are cooked through (white inside with some pink and red accents outside), transfer to a serving platter and set aside to cool.
Toast 8 tortillas over an open gas stovetop flame on medium/low heat (about 10 seconds per side) until lightly charred on the edges (or on a medium-hot skillet or griddle) until golden brown in some spots (30 seconds per side).
Thinly slice cabbage, dice the avocado, finely dice the red onion, and coarsley chop the cilantro. Add these to your serving platter along with lime wedges. Build tacos by arranging toppings and shrimp over each toasted tortilla.
In a small bowl, whisk together all sauce ingredients and serve with assembled shrimp tacos.
If you make this recipe, I’d love to see pics of your creations on Instagram, Facebook and Twitter! Hashtag them #natashaskitchen
These tacos are absolutely amazing! I make them for parties, they always get rave reviews!
That’s great, Jacqueline! I’m so glad they are a hit!
Amazing!!! Dont hesitate to make these! All 4 kids loved them. We doubled the recipe, except for sauce. Definitely a family favorite.
That’s lovely feedback, thank you for sharing!
I would love to make these but I generally do not like spicy food. Could the Sriracha be omitted or substituted in the sauce?
Hi Diane! That would be fine to omit the sriracha sauce. I hope you love the recipe.
Love, love, love this recipe! And your video is so adorable!❤
Keep doing what you are doing!
Thank you so much, Abbie!
How many tacos in a serving according to the nutrition facts
Hi E, it’s one taco per serving if using 6″ tortillas.
I want to begin by saying I’m not a huge fan of shrimp but MAN! this was delicious. Perfect shrimp tacos and perfect for lent. I switched up the recipe slightly, instead of salt, I used adobo.
That’s so great! It sounds like you have a new favorite, Genesis!
These were fantastic. Everyone loved them Definitely will make these again.
That’s just awesome! Thank you for sharing your wonderful review, Scott!
These were fantastic. I made the basic recipe, adding avocado and cilantro. I almost skipped the sauce, but I’m glad I didn’t, it really added tot he recipe. The only drawback is that the recipe was not in large enough quantities and next time I will add 1/2 as much shrimp and sweet potatoe chunks. Loved it.
Thank you, Patti! So glad it was a nit.
Fantastic! My daughter found your recipe and made these for us last night. They are better than a restaurant and bursting with authentic Mexican flavors!
That’s so great! It sounds like you have a new favorite, Diane!
I made this recipe for my boyfriend and he now thinks i’m a good cook. I won’t tell him my secrets
Great job! I hope you’ll both enjoy all the recipes that you will try.
I made these a few nights ago but combined the sauce with the slaw also and was so delicious 🤤
Hi Melissa! That’s wonderful. I’m glad you loved the recipe.
If we do not have a gas stove, how do you recommend cooking the corn tortillas? I’d love them to be charred like you described.
Never mind. I guess I did not read the instructions very carefully. Thank you!
No worries! 🙂
I just made this tonight and it was very, very good. I followed the recipe, made no substitutions. I tasted the sauce and thought it was just OK, but when combined with everything else, it is delicious. Thank you for this recipe, will definitely make it again and we’ll make it for company.
It’s my pleasure. I hope your friends and colleagues will love it too!
Just saw your video for these tacos. You are the cutest thing 😂 and the tacos look so delicious!
Making these for my family this week!! Thank you for the recipe!
You’re so nice! Thank you, T! I hope you all love this taco recipe!
Ooook. Made these for dinner last night. The husband and kids LOVED them. Kids kept commenting how good the tacos were and the sauce was. Will definitely make again SOON! Thank you!
That’s great! So glad the family loved them.
Yum! Perfect ingredients and the sauce is chef’s 💋! Served with home made refried black beans and guacamole…so good!
Hi Shawnna! I’m so glad you loved this recipe, it’s one of our go-to’s! 🙂
I came here for the shrimp sauce because, I was making fajitas and I didn’t have a recipe for one. I’m so happy I stumbled across this one. The sauce was delicious and perfect to lighten up all the spices in my shrimp fajitas. I used fresh lemon because I didn’t have a lime. I will definitely need to try the recipe in its entirety next time! Thank you. 🙂
That’s just awesome! Thank you for sharing your wonderful review, Yolanda!
Hi, can I use non dairy plain yogurt for the sour cream and mayo? I’m lactose intolerant.
Hi Paula, I haven’t tried that myself to advise, but you can try using Plain Greek Yogurt. I hope you love it!
I made these for taco night with the family……HUGE HIT!!! Thank you for another DELISH recipe, we will definitely be making these again!
Wonderful to hear, Janet! Thanks so much for the feedback.
Will continue to make this pretty regularly ! So good 👍🏻😊
So glad you loved it! Thank you for sharing.
Can you use frozen shrimp that is already cooked and thawed?
Hi Dawn! We prefer fresh, but that may work. Pre-cooked shrimp tends to get rubbery when heated.
Delicious! Only thing we added was some zucchini and corn salsa. Our whole family loved the tacos! No leftovers at all.
That’s when you know its good, Allison! THank you for your great review!
Delicious! But I have not had a bad recipe from this website! Every time I am looking for a recipe, I try here first!
Thanks so much, Laura! I’m so glad you love my recipes! I appreciate the support.
So amazing! The spice rub for the shrimp perfect but don’t breathe deep when cooking the shrimp or you’ll cough a bit. Worth it though. This is a keeper recipe that I’ll be making again and again! Thank you, Natasha!
I’m so glad you enjoyed it, Lisa! Thank you so much for sharing that with me.
Hello! Your recipe says it yields 8 tacos, but how many tacos are in a serving? Need to know for macro and micro nutrient calculations. Thanks!
Hi Danielle! It’s one taco per serving if using 6″ tortillas.
Excellent shrimp taco recipe! It’s become a household favorite.
This is 5 Star rated recipe and I just wanted to clarify. 🙂
Thank you, Ted for your perfect rating!
Great to hear that, Ted!
Do you think I could add the sauce to the cabbage to make a flavored slaw?
Hi Laura! I don’t see why not. 🙂
These pop up adds and banners are making it impossible to read the recipe on my phone! Seriously can’t even screenshot the directions because there is constantly something in the way on the screen! I can’t rate a recipe I can’t use. Ugh
Hi M! I’m sorry for the frustration. In order to keep our recipes free, we need to have ads. You could look into installing an Ad Blocker app to see if that would help.
i just go into developer mode and delete the ads, also recipe is delish
This is soooo on my Taco Tuesday rotation. Is there a place for me to make notes as I “heart” a recipe?
Hi Mary! I’m so glad you loved it! You can ❤ the recipe, but I don’t have a notes option. Thank you for that suggestion, though!
Do you add the cheese right to the coleslaw dressing or is it served on the side?
Hi Michelle! We use cheese as a topping on the taco.
Hi, have made this many times and think it is delicious, thanks. Do you think it would work to make a much larger portion of the fish and them freeze into smaller portions for batch cooking?
Hi! I’m glad you love the recipe. I have not tested freezing to advise. I think it could work but you’d have to experiment with it. Shrimp can get chewy and rubbery when reheated.
Oh my gosh!!! This recipe is a chefs kiss!!! The whole family loved it!! Don’t change a thing!!! It’s absolutely perfect!!!!
That’s so great! It sounds like you have a new favorite, Joy! I’m so glad it was a hit!
This recipe is delicious! The only thing I added was mango salsa, yummy!
We made these last night and will use this recipe again. We didn’t have red cabbage so used green cabbage instead.
I couldn’t find the cotija cheese so we used crumbled feta. They were delicious! The sauce is so good. Thank you very much for sharing this recipe.
Thank you for sharing, Jacquie! That sounds wonderful. So glad they turned out great.
Good, but a bit too spicy for us. Next time maybe a little less cayenne will help. Loved the sauce it was delicious. Will definitely make again.
Sounds good, Missy. Feel free to adjust the spice next time according to your preference. I hope you’ll love all the recipes that you will try!
Delicious! Easy peazy and packed a punch! I used shrimp- because it’s all I had lol- and I couldn’t not make this after reading. Worked just fine! I adjusted the cooking time and voila!!!! Used all the garnishes and now everyone thinks I’m a rockstar! Thanks Natasha!!! You ALWAYS make me look good! ALWAYS!!!!
Hi Tanya! Thank you for the wonderful feedback and review.
it would seem that by the time you uild the taco that everything would be cold? Do you reheat or eat at luke warm temps?
Hi Rich! We like to keep the shrimp covered until we are ready to build the taco. The shrimp tends to remain warm once we get to eat. BUT, some people have enjoyed it with cooled shrimp too! I hope you love this recipe!
A little sweet chili sauce added to the taco to top it off
I made this tonight and it was awesome. I made the cream sauce and was not impressed until I put it on the tacos. The sauce went perfectly with the tacos. Also, toasting the tortillas is a must. Restaurant quality.
I’m so glad you loved it, Jason! We believe it perfectly balances the shrimp flavor!
If there was a 10 star rating I would gladly give it. These tacos are easy to make and the pay off in taste is out of this world! So many flavors bursting through and she is right – the sauce is a killer!
Aaaw that’s amazing feedback, thank you!
Hey Natasha, I was wondering if you used cooked or raw shrimp and what size of shrimp is best for these tacos?
We used raw shrimp, the large 21-25 count shrimp. Medium (26-30 count) or even small shrimp (31-35 count) would work well. Keep in mind smaller shrimp will cook faster.
My husband and I made these taco’s and loved them. Putting in our rotation.
I’m so happy this was a hit, Kelly! Thank you so much for sharing that with me!
I had never had shrimp tacos before I tried the recipe. I was skeptical for whatever reason. This is an easy, yummy, recipe that my picky son will even eat and gets excited for! Fresh vegetables and all you have to cook are the shrimp!!! The sauce was sooo good. I used Miracle Whip instead of Mayonnaise. I love this recipe! It will be my go to for shrimp tacos now and forever!!!
Yay that’s perfect! Thanks a lot for your good comments and feedback, Brittney.
This recipe is wonderful. I had to keep eating. Nothing I have made compares to this. Thank you.
Wow! I’m so glad to hear that, Linda. Thank you for sharing.
I tried Tasha’s shrimp taco recipe, it was the BEST TACOS I’ve ever had and family also commented that it was the best I’ve ever made!! Better than any restaurant and was super easy! Also did the sauce and it was wonderful Thank you
You’re welcome! I’m so happy you enjoyed them. Thank you for sharing with us.
Hello Natasha, These were amazing and pretty simple. I put the shrimp on skewers and grilled them. I will definitely be making this again. Thank you!!
You’re welcome! I’m so happy you enjoyed it, Julie!
How long can you keep the sauce? I was thinking about making it ahead of time to have more time with company.
Hi Carolyn, I haven’t had it in the fridge for longer than two days; it doesn’t last long enough in our house, haha. But a think a couple of days will be fine.
Made quite a few of Natasha’s recipes and they’re always a winner!
Thank you for that wonderful comment, Michele! I’m so happy you’re enjoying my recipes!
I just made these tonight. Absolutely the best. I lived in mexico for 10 years and they remind me of how the Mexicans make there’s. Thank you for sharing your recipe. I didn’t change a thing no need to, and will be making them again.
That’s awesome! So glad you enjoyed this recipe, Donna. Thank you for the wonderful review.
These tacos were fabulous. The sauce was so good. The shrimp alone was seasoned perfectly. I Would not change anything and followed the recipe exactly.
Thank you for the awesome feedback! We appreciate it.
Well this sure put a wrench in my meal plan for tonight. Found this last night after I had thawed out pork chops and planned a meal around them. Instead we are having shrimp tacos for supper tonight, prok chops were breakfast with waffles instead. Thanks so much for this, the sauce is divine.
You’re very welcome, Mary! Enjoy the recipes that you will try.
I followed the recipe almost exactly but actually made this into a burrito bowl for my husband’s work lunch instead!
In lieu of tortillas I made lime rice and warmed up a can of Mexican style black beans.
The sauce really is amazing and the shrimp was delicious.
I will have to come back for the sauce every tacoo night from here on out! Totally understand why there was emphasis on amazing!
I also ended up adding a splash of rice vinegar, lime juice and sea salt to the cabbage and massaging it in with my hands just for an extra bit of flavor.
Didn’t have cotija but subbed with feta.
Overall, the recipe provided is definitely a 10/10!
I highly recommend it, and if not the shrimp, at least make the sauce!
Thank you for your excellent review, Victoria! I’m so happy you loved it!
I’ve been looking for a good shrimp taco recipe and think I’ve found it based on the great reviews! Can’t find cotija, feta or monterey jack? Also since we don’t like cilantro, should I just leave it out or use parsley? Thanks!
Hi Cathy, you can leave out the cilantro if you’re not a fan. I found cotija at the grocery store next to the refrigerated tortil; dependinging on the store they may be in sections other than your cheese section. Some of my readers mentioned using fresco or Panela cheese, others said feta cheese, and they liked it too. I hope this is helpful!
Made this recipe tonight and it was delicious! I used pre made coleslaw and added my homemade dressing then put that on the tacos and also used as our side dish. I also added garlic powder, onion powder and chilli powder to the shrimp. Lastly I added a bit of cayenne pepper to the sauce as we like a little bit of heat. They were so good! Will definitely make again.
Thank you for you sharing that with us, good to know that you loved the result!
I just got married a week ago and didn’t know what to cook. Found this recipe and my husband LOVED it!! So simple, yet flavorful! Thank you!!
Hi Vanessa, that’s wonderful! So glad you both enjoyed this recipe.
great recipe! only thing i did different was saute’ the red onions. if not cooked thoroughly they are really bad for the female private parts. i am always careful with any type of raw onion. Saute’ed or grilled onions work well too!
Thank you for sharing that with us, Christine. We appreciate the tip!
Thank you so much for sharing that with us, Christine!
Amazing and easy to make. My husband loved them. No leftovers. Just the right amount of spice
Thank you for sharing that with us! I hope your family will love all the recipes that you will try for them.
Making this recipe for my family tonight! May I ask what kind of mayonnaise did you use?
Hi Petula, I believe I used Hellmann’s for this recipe! I hope that helps!
My family LOVED your shrimp taco recipe and the sauce was AMAZING!!
So glad it was enjoyed!
I first made the fish taco recipe using tilapia and followed the recipe exactly. This fish sauce is the best ever!!! Tonight, I made the shrimp tacos and cooked them on the grill. They were better than any I have had at a restaurant. The seasoning is so delicious and the tang of the cotija cheese and brightness of the lime just makes these tacos the best! No more going to a restaurant for fish/shrimp tacos. These are the best! Thank you, we will be making these often
Love this! Thank you for sharing your detailed feedback with us, we appreciate it!
Wow! I have never been inspired to ever leave a review on a recipe…until today. I made this from my husband who requested a shrimp dish for Father’s Day and my family can’t stop sharing how delicious the tacos are! “Restaurant quality… Mom can we have more… Why haven’t we had this before!” Thanks for sharing the recipe Natasha!
Hi Julie, that’s so heartwarming. Thank you so much for sharing that with us. I hope your family will love all the recipes that you will try for them.
Hi Natasha..I would like to see you make spaghetti salad…I love your salads..but I don’t like avocados…
Hi Donna, thanks for your suggestion. I’ll try to add that to our list.
Soooooo good!!! What a great recipe to mix things up a bit! Super easy to prepare, staple ingredients, but far from an ordinary dinner! My entire family enjoyed this, kids included!
That’s wonderful! So glad it was enjoyed.
Any tips on what I should use in place of Siracha sauce since it seems there is a severe shortage at this time? Perhaps a tabasco sauce (which my husband has a wide variety of)?
Hi Holly, we always stick with the same one, but I think it would work to substitute with another and add to the taste. If you happen to experiment with tobacco or another brand, I’d like to know how you like that.
My family doesn’t like Shrimp. (I do though LOL) Can I substitute Chicken for this recipe instead?
Hi Tracey! Yes, I think that would be just fine.
OMG, I did it with Chicken and it was delicious!! I used Chicken Breast and diced it very fine, fried them like she did the Shrimp. I used a little bit more spice than the recipe because the Chicken Breast was over 1 Pound. I didn’t change anything else and it was delicious!!
That’s wonderful! So glad you enjoyed this.
As a new housewife, I work hard at making amazing dinners for my husband, which is way harder when you don’t really know how to cook!! I choose different recipes and give them a whirl. My husband gave this recipe 10 out of 10! So super easy and amazing flavor! Definitely a keeper for the cookbook. I will be making this again and again!!
Hi Anne! Thank you for the wonderful review. So glad you found a keeper.
This was fantastic! I changed the order of the directions. I made the sauce first, seasoned and refrigerated the shrimp, then cut up the toppings. I cooked the shrimp and tortillas last. We like the shrimp warm. I will definitely cook this again!
I’m glad you liked the result, Roni!
Made these tonight and my son said, these are better than Tin Roof tacos. I made double of the sauce so we can have shrimp or fish tacos this week! Really great- bravo!
So glad to hear that!
This is literally the *BEST* recipe ever! I made this 3 days in a row because my family couldn’t get enough of these. Incredibly easy to throw together and the fresh taste is better than anything I’ve ever had in a restaurant. Perfect amount of spice for flavor as well. Definitely an award winning recipe, thank you so much for sharing!! Now I’m hooked on trying all your recipes so keep them coming because I’m telling everyone about you.
Wow! That’s just awesome! Thank you for sharing your wonderful review, Sandra! It sounds like you found a new family favorite!
What kind of shrimps do you recommend? wild caught? a lot of shrimps have bad preservatives. I appreciate your help.
Hi! I don’t have a preferred brand. We used raw shrimp, the large 21-25 count shrimp. Medium (26-30 count) or even small shrimp (31-35 count) would work well. Keep in mind smaller shrimp will cook faster.
she said shrimps as opposed to shrimp ,, i love a good chuckle.
Making these tonight for the first time. Can you tell me how many servings you would estimate this is. I am counting calories and I see it is 308 calories per serving but how many tacos make a serving? Thank you!
Hi Nancy, it’s one taco per serving if using 6″ tortillas.
I’m making these for the 500th time…I might not be exaggerating! Everyone I’ve served these to is in LOVE! You won’t be sad if you give these a try! I promise!!!
That’s lovely feedback, Amanda. Thank you so much!
Made this tonight; it is so quick and so good! Sauce is the bomb. We also topped with some mango salsa. Thanks for another great recipe.
Yum! I’m craving this today! I’m so glad you loved these tacos, Susan!
We love your shrimp fajitas but THESE TACOS! So good! We almost cut corners and used a prepared sauce and so glad we didn’t. It has so much flavor! I also forgot to squeeze lime juice on my first taco and really missed out. The lime juice really freshens up the flavor. We can’t wait to make again!
That’s so great! It sounds like you have a new favorite, Tricia!
I didn’t create the sauce but I followed the way to cook the shrimp and the the tortilla. Turned out amazing!
Happy to know that you enjoyed it!
These shrimp tacos are seriously just wow we enjoyed them so much! First time making them tonight mouthwatering. 10/10 thanks for the recipe Natasha never a disappointment with your recipes. As I’ve made quite a few. Your website is always a go to website for me!
Wow, thank you for the perfect rating. That really makes us feel inspired and happy!
These shrimp tacos are excellent. And the sauce is exactly what I was looking for. We are enjoying this recipe very much. THANK YOU
You’re welcome, Vicki! I’m happy to know that you loved this recipe a lot.
WOWWWWW SO GOOD .!!
Just made them for me and my
Mom and it was DELICIOUS.!!
Definitely 5 stars
Thank you so much
Thanks for the perfect rating and great feedback, Erica!
Natasha has done it again. These are amazingly delicious tacos. And the sauce soooo good. We use it on so many different dishes and types of meats. WOW. And so easy to put together.
You’re so nice! Thank you for that great review, Andrea!
This is one of my family’s favorite recipes and one that we make often. I follow the recipe exactly and it’s just perfect.
Aww, that’s the best! Thank you so much for sharing that with me, Janet!
do you think I could make this recipe in the oven
I am trying to make something for toddlers to eat and thought If I could make the tacos flat and layered I could cut them up for them to eat?
Hi Shelby, I haven’t tested that method, the only thing that needs to be cooked here in the shrimp and the tortillas warmed.
Natasha, I was nervous about trying & eating shrimp tacos. Once I saw your recipe I decided I trust you and would give it a try. It was absolutely amazing!! I will be treating my friends & family with this dish. Thank you so much! You’ve never disappointed me with your recipes!
Thank you for the trust and I’m happy that you loved it!
PS: The sauce is ah-mazing!! I’ve used it on several other dishes!
I’m so glad you enjoyed it!
NEVER had any kind of fish tacos before. This one is awesome and easy (best combo!) Making it for the umpteenth time tonight–by request!! Thanks for all your recipes!!
That’s so great! It sounds like you have a new favorite!
My go-to Shrimp Taco recipe. So easy and delicious! My family does not like purple cabbage, so I just use regular out-of-the-bag coleslaw…the Shrimp Taco Sauce makes tacos so tasty!
Sounds great and glad you loved this recipe, Virginia!
This is my 3rd time making this recipe. It was a hit with my husband who loves fish tacos. I used Shrimp twice and Cod once. It will be a regular at mealtime!
That is great! I’m happy you enjoy this recipe! Thank you for the review.
This is our second time first tike was fish!! Thus time around its Shrimps can’t wait also made Bacon wrapped Jalepeno Poppers but instead of cream cheese we are using a whipped cheddar !! Can’t wait!!!
Super simple and super tasty! A winner meal in our home. Thank you Natasha for sharing this awesome recipe!
You’re welcome, Mary. So glad you love it!
These were absolutely friggin DELICIOUS. Followed the recipe to a T and everything turned out great. That sauce is next level. Wow. My tummy is happy! Mmmm!
Excellent! Thank you for the review. I am happy to hear that!
We loved this recipe! I was worried about the shrimp being too spicy but it wasn’t. My family said it was the right amount of spices and they loved the taste. Thank You 🙂
That’s just awesome! Thank you for sharing your wonderful review, Jennifer!
Are these super spicy cause of the cayenne pepper? We like spicy but not so spicy your mouth is on fire the whole time.
HI Candy, the spice is pretty mild with only 1/4 tsp cayenne pepper and not overly fiery or spicy.
Recipe sounds delish. I am curious though is all that sodium from the cojito cheese?
Hi Karen, the cotija and mayo have sodium, but the shrimp itself has sodium also!
Great recipe! I wouldn’t change a thing. Very easy to follow.
I’m glad you loved it, Lucille!
Have to tell you, these came out great. 11 yr old daughter loves seafood, couldn’t get enough. 10 yr old boy who is iffy on seafood said he would eat it every day. Wife was out for the evening, not a seafood fan so that’s when I make it, and she ended up jealous and wants to try next time. Will be doubling the recipe for sure. After this, I will be looking through more of your recipes.
That is awesome, Sean. Great to hear that your family enjoyed this recipe. I hope you will all love the recipes that you will try!
I’ve made countless of your recipes, and this and the chicken & rice/plov are my absolute favorites! The sauce in these tacos is unbelievably tasty (and the kids love squirting it out of a fancy restaurant-like bottle). This is the 3rd time I’ve made it, and will NOT be the last. Thank you for alllll your amazing recipes and for making my kids and hubby think I’m the best cook!
Love it! Thank you for sharing your experience trying this recipe, Alisha. I’m happy to hear that you liked it!
This receipe was a hit with the family, they said it was the best shrimp tacos they have ever had…the creamy sauce was delicious and used it to grill some salmon and it was so yummy…Thanks Natasha!
Thanks for the compliment and great review, Jeffrey! Happy to know that your family enjoyed these tacos.
My husband said it’s the best thing he ate in the last 6 months!
That’s just awesome! Thank you for sharing your wonderful review, Victoria!
Love this! We used oregano instead of cilantro (Mexican oregano).
Hello Melinda, great to hear that you loved this recipe! Thanks for your review.
Hi, can I use lemon instead of lime?
Hi Dami, we prefer it with lime but I bet that could work with lemon too.
I only have precooked shrimp at hand. Can I still make this recipe work out?
Hi Andrea, we prefer fresh, but that may work. Pre-cooked shrimp tends to get rubbery when heated. If you experiment, I would love to know how you like that!
I make these OFTEN! My family absolutely loves this recipe! I also make the fish tacos and bulgogi tacos! YUM! Better than restaurants or takeout!
Our favorite too! I’m so glad you all enjoyed this recipe, Amanda!
Delicious! We made this for dinner tonight. They were delicious. The whole family loved them and the sauce was so good.
That is awesome! I’m glad the recipe was a hit, Janet. Thanks for sharing that with us.
Delicious! My husband and I both really enjoyed these! I used broccoli slaw instead of the cabbage. Next time we make it, we’ll add a little of that delicious sauce into the slaw before we assemble the tacos.
That’s just awesome! Thank you for sharing your wonderful review!
This is gonna be my Mother’s Day fiesta dinner, made by my family, not me. I can’t wait !
Yum! The perfect Mother’s Day treat!
I made these yesterday, and had some as leftovers today. So good! I kept snacking on the cooked shrimp before I finished the recipe.
Then, I accidently ate the first taco without sauce! It was yummy even without the sauce. I have lots of leftover sauce. I was thinking it would taste great on hamburgers, too.
That’s so great! It sounds like you have a new favorite!
You mentioned that you could make this ahead…how would you heat it up? Looking forward to giving this a try!
Hi Mary, yes, the sauce can be stored for a couple of days in the fridge.
Hi I see per the nutrition facts 1 serving is 308 calories. However, it doesn’t say how many tacos make 1 serving?
Hi Paula, the number of servings is always at the top of the recipe card and the nutrition label is per serving. In this case it is per taco.
Delicious and this sauce was amazing!
I’m so happy you enjoyed that. Thank you for sharing that with us, Jolie!
I just need to tell you how fun I find you and your cooking videos!! Thank you for being you, Natasha! You’re a bright spot in my world. 😀
You’re so sweet! Thank you for your good words and feedback. I appreciate your support, Sallie.
Really really good! So good Im going to buy more shrimp next time I go to the store!! Loved them. Recipe could probably be adapted to other fillings besides shrimp pretty easily too. Easy to make too!
Yes, I imagine that would work! Glad you enjoyed this recipe, Sally.
OMG Natasha these are so delicious. I tweaked them a little to go with I could find. I kept my shrimp warm. Thank you so much for your wonderful recipes.
You’re welcome, Gial! I’m so happy you enjoyed that. Thank you for sharing that with us!
Just finished eating these tonight. They were a huge hit! I will make them again very soon!
That’s just awesome! Thank you for sharing your wonderful review!
How long would this sauce be good for once mixed? Thanks in advance!
Hi Liz, I haven’t had it in the fridge for longer than two days; it doesn’t last long enough in our house, haha. But a think a couple of days will be fine.
Ive use the sauce on salad as a light dressing… delish
Made these this weekend and we loved them… the sauce was great, this is our 3rd recipe we have made with your help
Thank you again for sharing
Hello Iliana, I’m glad you loved this recipe! Thank you so much for sharing that with us.
Made this delicious meal for dinner tonight. It’s a gorgeous platter of tasty flavours and textures
That’s so great! It sounds like you have a new favorite!
Is there any way to adapt this to the Air Fryer for the shrimp?
Hi Denise, I haven’t tested that, but it may work. If you experiment, let me know how you liked the recipe.
Would this receipt be considered gluten free?
Hi Susan, yes, They are served over toasted corn tortillas, so they are naturally gluten-free.
i made this for dinner and kids loved it.
That is the best when kids love what we parents make. That’s so great!
Made these for dinner and they were amazing! My picky husband loved them. Definitely will be making again.
Perfect! I’m glad you and your husband enjoyed this recipe for dinner.

domain: food


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One of the paradoxes of drug regulation is that children have ended up being denied the protections afforded by the very laws which were introduced to ensure the efficacy and safety of drugs following disasters such as the thalidomide tragedy. Children have become therapeutic orphans1 because they are either denied the use of many new medications or exposed to medications that have bypassed rigorous evaluation. Many marketed drugs that are commonly used, or could potentially be used in children, have not been studied in the relevant age groups2 and so are not approved by regulatory authorities for use in children.
Information about the safety and efficacy of medications in the youngest, and most vulnerable, paediatric age groups is especially scarce.2Any prescription of drugs outside the specifications of the product licence (such as for a different age, dose, route or indication) is 'off-label' use.3Some medicines that are given to children are not registered by the Therapeutic Goods Administration for any indication in adults or children ('unlicensed' use).
This paradox poses significant clinical, ethical and legal dilemmas for prescribers4. It is difficult to practise evidence-based medicine when there is little (or no) evidence. Yet, clinicians tend to choose to prescribe a new drug despite a lack of paediatric data rather than deprive children of a potentially beneficial therapy. The practice is widespread; between 40 and 90% of paediatric prescribing is for off-label use or for unlicensed drugs.3,5 Although unlicensed or off-label prescribing is not illegal, and in some cases may be entirely appropriate, it does bypass the safeguards of the drug regulatory process and places a greater onus of responsibility on the individual prescriber. The validity of 'informed consent' to therapy based on little or no information also raises ethical concerns.4
While unlicensed or off-label prescribing may be acceptable as an exception, it is clearly unacceptable when it becomes the rule. Children are disadvantaged in many ways by this situation.
First, extrapolating the results of adult studies means that children may be exposed to ineffective therapies (or to ineffective doses of potentially effective therapies) and to unknown risks of adverse effects. There are many biological differences between adults and children of different ages which mean that the evidence of effectiveness and safety in adult studies is not generally applicable to children (for example chloramphenicol and the grey baby syndrome).
While it may be tempting to give the benefit of the doubt to new drugs that have not been studied in children, this may place more children at risk than if the drug was used as part of a controlled trial.6Adverse effects are more common when drugs are used off-label7and some children have died as a result.8Ironically, this information is also hard to come by since spontaneous reporting of adverse drug reactions as part of standard post-marketing surveillance may be less likely with off-label prescribing.2,4
Second, the lack of information about new drugs means that children may be unable to benefit from therapeutic advances that are available to adults.
Third, even if a drug has good evidence of paediatric efficacy and safety, it may be unavailable in formulations (for example liquids) that are suitable for children.
Fourth, evidence from well-conducted studies in children may not always be reflected in the product information, if it becomes available after marketing of a new drug. This results in the contradictory and confusing situation (for the prescriber and consumer) where prescribing is evidence-based yet not consistent with the product information, which may state 'Not approved for use in children'. As Consumer Medicine Information leaflets are based on the product information, children and parents are further disadvantaged by not having access to appropriate drug information.
Fifth, the current system also means that children are denied equitable access to subsidised medication. The Pharmaceutical Benefits Scheme does not include off-label prescribing.
Finally, uncritical acceptance of widespread off-label drug use by prescribers additionally disadvantages children by removing the incentive for the pharmaceutical industry to properly evaluate drugs for paediatric use.
The pharmaceutical industry has been reluctant to conduct drug studies in children, mainly because of the low profitability and perceived greater risks of paediatric drug research. Many of the other obstacles to drug research in children have been largely overcome by recent advances in research methods and development of collaborative approaches between investigators.9,10 Drug studies that are scientifically valid, feasible and ethical are now possible and 'there is a moral imperative to formally study drugs in children so that they can enjoy equal access to existing as well as new therapeutic agents'.6The Food and Drug Administration in the USA now requires manufacturers of new and marketed drugs to conduct paediatric studies and in some circumstances will provide financial incentives for this research.9 Similar changes are currently being proposed by the European Union.11
The policy changes in the USA have vastly increased the number of drug studies in children and expanded the evidence base for paediatric therapeutics. However, it is evident that these initiatives have favoured the study of more profitable drugs. Drugs lacking patent protection (for example most older antibiotics) and those with a small market still remain unstudied.12 Public funding is therefore being made available in the USA specifically for the study of off-patent drugs used in children. This initiative should go a long way towards remedying the woeful state of the evidence base for paediatric therapeutics. Australian children will no doubt benefit greatly from these global initiatives, but much more work needs to be done before they enjoy truly equitable access to useful medicines.
Developing successful solutions for this age-old problem requires new ways of thinking and action by all concerned. Clinicians should work with researchers to ensure that the study of medicines likely to deliver the greatest health benefit to children receives the highest priority. Drug companies should be encouraged to conduct more high quality research on drugs that may be used in children and to ensure that available research is incorporated into the product information.
Clinicians, researchers, policy makers and consumers should work together with the pharmaceutical industry to develop innovative ways of achieving these goals as a matter of urgency.
We have allowed children to remain therapeutic orphans for far too long. Clear and feasible solutions now exist to remedy this problem. It is time that we stopped discriminating against our children and high time that we finally gave them their rights to the benefits of full therapeutic 'citizenship'. They deserve nothing less and nothing less will do!
- Shirkey H. Therapeutic orphans. J Pediatr 1968;72:119-20 .
- Stephenson T. Medicines for children - the last century and the next. Arch Dis Child 2001;85:177-9.
- Conroy S, Choonara I, Impicciatore P, Mohn A, Arnell H, Rane A, et al. Survey of unlicensed and off label drug use in paediatric wards in European countries. Br Med J 2000;320:79-82.
- Collier J. Paediatric prescribing: using unlicensed drugs and medicines outside their licensed indications. Br J Clin Pharmacol 1999;48:5-8.
- Pandolfini C, Impicciatore P, Provasi D, Rocchi F, Campi R, Bonati M, et al. Off-label use of drugs in Italy: a prospective, observational and multi centre study. Acta Paediatr 2002;91:339-47.
- Committee on Drugs, American Academy of Pediatrics. Guidelines for the ethical conduct of studies to evaluate drugs in pediatric populations. Pediatrics 1995;95:286-94.
- Turner S, Nunn AJ, Fielding K, Choonara I. Adverse drug reactions to unlicensed and off-label drugs on paediatric wards: a prospective study. Acta Paediatr 1999;88:965-8.
- Bray RJ. Propofol infusion syndrome in children. Paediatr Anaesth 1998;8:491-9.
- Conroy S, McIntyre J, Choonara I, Stephenson T. Drug trials in children: problems and the way forward. Br J Clin Pharmacol 2000;49:93-7.
- Cohen SN. The Pediatric Pharmacology Research Unit (PPRU) network and its role in meeting pediatric labeling needs. Pediatrics 1999;104:644-5.
- Better medicines for children: proposed regulatory actions on paediatric medicinal products. Brussels: European Commission; 2002. http://pharmacos.eudra.org/F2/pharmacos/docs/Doc2002/feb /cd_pediatrics_en.pdf Overview of comments on Better Medicines for Children. Brussels: European Commission; 2002. http://pharmacos.eudra.org/F2/pharmacos/docs/Doc2002/june /overchild.pdf
- Department of Health and Human Services. US Food and Drug Administration. The pediatric exclusivity provision. January 2001 Status Report to Congress. Rockville (MD): FDA; 2001 www.fda.gov/cder/pediatric/reportcong01.pdf
- Gazarian M, Murray K, Roberton D. Discontinuation of naproxen suspension [letter]. Aust Prescr 2002;25:104-7.

domain: medical


This project was funded by the National Institute for Transportation and Communities (NITC) under grant number (1024). The project also benefitted from matches from the Oregon Department of Transportation, TriMet, University of Utah, and Portland State University. Furthermore, we acknowledge and thank the anonymous peer reviewers who provided helpful insights and corrections to the report, which is published in the Journal of Transport Geography (Wei et al., 2017).
Transit oriented development -- Research, Transit oriented development -- Case studies, Local transit -- Planning, Transportation -- Planning
Assessing the performance of public transit services has long been an important yet challenging issue for transportation agencies and researchers. Transit service performance measurement reflects a very first step towards an efficient and proactive management, where public transit agencies are increasingly pressured to provide high-quality services in spite of constrained resources. However, the performance evaluation of transit services is complicated by an array of quantitative measures available to assess the goals and the diversity in the goals themselves, which usually include improving operational efficiency and providing equitable access. While much previous work has examined public transit services for achieving optimal operational efficiency and/or access equity separately, the interplay of the two has rarely been investigated to date. This project developed a comprehensive framework and an open-source toolbox for evaluating and enhancing the overall performance of public transit systems by using a combination of mathematical programming methods, GIS-based analysis and multi-objective spatial optimization techniques. This framework enabled operational efficiency and access equity of transit systems to be assessed in an integrated manner. The python open-source toolbox operationalized the framework and make it accessible to transit planners, decision-makers and the public. The framework and the toolbox are applied to assessing the performance of fixed-route bus services operated by the Utah Transit Authorities (UTA) in the Wasatch Front, Utah, and transit services operated by TriMet in the Portland metropolitan area. Results demonstrate that the developed framework and toolbox can effectively account for operational efficiency and access equity in an integrated manner, providing a more comprehensive assessment for transit service performance.
Wei, Ran, Aaron Golub, Liming Wang, and Thomas Cova. Evaluating and enhancing public transit systems for operational efficiency, service quality and access equity. NITC-RR-1024. Portland, OR: Transportation Research and Education Center (TREC), 2018. https://doi.org/10.15760/trec.203


Reserve Bank of India governor Shaktikanta Das on Monday made it clear that there was no plan to reintroduce ₹1,000 currency notes. Addressing the media on the RBI’s recent decision to withdraw ₹2,000 currency notes, Das said the impact of the move will be “very very marginal” on the economy because it accounts for only 10.8 per cent of the currency in circulation.
RBI Governor Shaktikanta Das.(PTI) When asked about the potential reintroduction of ₹1,000 currency notes, Das responded, “That’s speculative. There’s currently no proposal for such a measure.”
Also Read | How to exchange your ₹2,000 notes after RBI scraps circulation: All FAQs answeredHe emphasised that the current denominations of ₹500 and ₹100 are abundant and readily accessible to the public, alleviating any apprehensions about the central bank’s ability to manage without the highest-valued currency in India.
The governor highlighted the ample quantity of printed notes already present within the system, stressing their availability not only with the RBI but also at the currency chests managed by banks.
Das reiterated that ₹2,000 notes will retain their legal tender status even after the central bank’s decision to withdraw them from circulation. He also urged the public not to create a rush at bank branches, expressing his belief that there is no need for people to hastily visit banks.
₹2,000 notes withdrawal: What did RBI governor say on impact?The RBI governor said the introduction of ₹2,000 bank notes aimed primarily at replenishing the notes withdrawn during demonetisation has served its purpose.
Further answering the questions arising on what will be the impact of the move, he said, “There will be no impact on economic activity.” He cited personal experience and informal surveys that reveal the limited usage of ₹2,000 notes in economic transactions.
Also Read | After RBI’s big order, Zomato says 72% of CoD bills paid in ₹2,000 notesNews agency PTI reported that 89 per cent of the ₹2,000 denomination banknotes were issued before March 2017 and have reached the end of their estimated lifespan of four to five years.
The total value of these banknotes in circulation has significantly decreased from its peak of ₹6.73 lakh crore on March 31, 2018, (accounting for 37.3 per cent of the notes in circulation) to ₹3.62 lakh crore, constituting a mere 10.8 per cent of the Notes in Circulation as of March 31, 2023, the report further said.
Exchange to begin on Tuesday, deadline till September 30Starting from Tuesday, the process of exchanging or depositing ₹2,000 currency notes will be facilitated, subject to the RBI’s current deadline of September 30. Individuals can exchange a maximum of 10 currency notes at a time, while the existing Income Tax requirement of PAN for deposits of ₹50,000 or more will be applicable to ₹2,000 notes as well.
Also Read | Why RBI decided to withdraw ₹2000 notes within 7 yearsNotably, the State Bank of India has announced that no ID proof or requisition slips will be necessary to exchange ₹2,000 notes. In anticipation of the summer season, the RBI has instructed banks to ensure suitable infrastructure at branches, including shaded waiting areas and drinking water facilities. Banks are also required to maintain daily data on the deposit and exchange of ₹2,000 banknotes.
However, the governor of the central bank mentioned that the September deadline may be revisited based on the prevailing circumstances.
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This gorgeous maxi dress will have you dreaming of fabulous summer occasions! Featuring a lovely solid color paired with a flowing silhouette, this beautiful look is so easy to dress up or down for any event! Featuring sexy v-neckline with lace-up and ruffle detail, elastically cinched high waistline, while the flowing high-low skirt makes it a graceful and elegant look! Add heels and a statement necklace to dress this look up for a spring wedding, or keep it casual with wedges and a few statement bracelets for Easter brunch!
Features •Lightsome flowing dress for summer •Simple color and delicate details makes perfect •It is great to show your sexiness and elegance in it •Wholesale maxi dresses are timeless fashion for women
Note: 1. There maybe 1-2 cm deviation in different sizes, locations and stretch of fabrics. Size chart is for reference only; there may be a little difference with what you get. 2. There are four kinds of elasticity: High Elasticity, Medium Elasticity, Low Elasticity and None Elasticity. 3. Color may be lighter or darker due to the different PC display. 4. Wash it by hand in 30-degree water, hang to dry in shade, prohibit bleaching. 5. There maybe a slightly difference on detail and pattern of this dress.

domain: design


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Ali Xeeshan’s ART – Sold Out Before It Was Hung
Ali Xeeshan is one of the biggest names in the fashion industry. Quirky and eccentric, Ali Xeeshanlives and breathes grandeur. His designs can be anything, but insignificant. He is essentially a visual artist and his craft is not limited to clothes.

domain: artistic


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BBC Play of the Month: Season 8, Episode 5
The Adventures of Don Quixote (23 Apr. 1973)
TV Episode | | Drama
A self-proclaimed "knight" and his hapless squire travel the Spanish countryside, attacking "giants" that are really windmills in his attempt to win the love of the fair Dulcinea.


Sioux Falls Stampede
Waterloo Scores Convincing Win Over Stampede
Payback was on the on the minds of the Waterloo Black Hawks as they avenged a lopsided 8-3 loss to the Sioux Falls Stampede on Jan. 9 with a 7-1 victory at the Arena Friday night.
Stampede Come Up Short In A Shootout At Sioux City
The Sioux Falls Stampede rallied from a late 4-3 deficit to tie, but came up short in a shootout, falling 5-4 to the Sioux City Musketeers Saturday night at the Tyson Events Center.
Stampede’s Win Streak Snapped In Omaha
The Sioux Falls Stampede saw their three-game winning streak come to an end Wednesday night in a 5-3 loss to the Omaha Lancers at Ralston Arena.
Stampede Hold Off Sioux City for 9th Straight Win
SIOUX CITY, IA - Two goals in the first period and strong goaltending by Charlie Lindgren were enough for the Stampede on Saturday night in Sioux City as they took down the Musketeers 2-1 for their ninth straight win.
Stampede Rally To Sweep Away Musketeers
Sam Rothstein scored the game winning goal and Charlie Lindgren stopped all three shots he faced in the shootout to give the Sioux Falls Stampede a 5-4 win over the Sioux City Musketeers Saturday night at the Sioux Falls Arena. The Herd overcame a 4-2 third period deficit to earn a weekend sweep of…
Stampede Top Bucs for Fourth Straight Win
A pair of big nights from Zeb Knutson and Thomas Forgione powered the Sioux Falls Stampede offense as they overwhelmed the Des Moines Buccaneers 4-2 at the Arena Sunday night in front of 3,478 fans.
Stampede Stumble In Omaha
C. J. Franklin scored the lone goal for the Sioux Falls Stampede in a 5-1 loss to the Omaha Lancers Sunday night. Despite the loss, the Herd remain in first place in the USHL Western Conference.
Stampede Tops in USHL Attendance
The Sioux Falls Stampede announced that the club leads the USHL in attendance through the first two and half months of the season.
Stampede Move Into First Place With Win at Sioux City
Preston Hodge’s first goal as a member of the Sioux Falls Stampede in the second period proved to be the eventual game winner as the Herd downed the Sioux City Musketeers 3-1 Sunday night at the Tyson Events Center.
Shorthanded Stampede Shut Out Storm
Missing their top three scorers, the Sioux Falls Stampede got goals from Thomas Forgione and Ryan Siiro and a stellar performance between the pipes from Charlie Lindgren to earn a 2-0 victory at the Viaero Event Center over Tri-City Friday night.


Focusing on reducing emissions and improving fuel economy, automotive manufactories are developing Electric Vehicles (EV) to replace fuel and diesel vehicles starting in 2030~2040. The green power supply EVs to make a maximum environmental benefit, zero-emission, and lower pollution. However, changing climate occurs intermittently which results in spinning reserve of electric power. Fortunately, a stable electric storage system (ESS) may compensate for this problem.
Electromagnetic induction transmits power from the source to the load via air gap based on the Faraday theorem, Ampere theorem, and Maxwell equation. A power pad combines with a turned network (or compensation network) constituting a resonant circuit to transmit and receive more massive energy efficiently. As a result, it can efficiently transmit massive power with a higher efficiency up to 90%, the quality factor of 5~100, a coupling factor of 0.2~0.5, and fundamental operating frequency range from hundreds of Hz to several 100 kHz through an acceptable air gap. These achievements are a credit to high-frequency semiconducting switching components with less power loss, and a tuned compensation network can compensate for power transmission loss due to lateral misalignment between coils. In addition, high quality power pads can provide a higher magnetic flux to overcome the limitation of air gap.
A static battery charging system with a heavy electric storage tank will definitely help the vehicle to achieve a longer traveling distance. However, the heavy electric storage system will encumber the vehicle and produce more pollution to environment. On the contrary, a dynamic battery charging system can reduce the vehicle battery size and weight while increase vehicle driving efficiency. However, the system needs to integrate various infrastructures such as the wide spread battery charging stations.
Adaptive compensation of the magnetic inductive system (ACMIS), based on zero voltage switch (ZVS), transmitting electric power from a single-end inverter combined with a compensated network of parallel to parallel (P-P) type and an auto-tuning impedance of LC tank is introduced in this book. The issue of simultaneous power and data communication is covered. The coherent wireless data transferring scheme including handshaking communication, current trimming mechanism, and a data attached scheme which synchronizes with the power flow via magnetic link. The advantages are low cost and RF radiation and interference. In addition, it simultaneously carries feedback of the load side’s message in real time. The experiment for a multifunctional contactless power flow of the G2V mode and bidirectional outer communication and inner communication with giant magnetoresistance (GMR) effect for car parking guidance is introduced. The experiment analyzes data transferring performance including the current trimming method and data attached method to evaluate data transmission quality according to the varying lateral offset, output power, an air gap between two inductive power pads.
About the Author:
Chih-Cheng Huang was born in Taichung, Taiwan, in 1970. He received the M.S. degree in electrical engineering from National Chung Hsing University, Taichung, Taiwan, in 2012 and the Ph.D. degree in 2017 from the same university. He is currently an Assistant Researcher who works with the Department of Electrical Engineering, National Applied Research Laboratories, Taiwan. His research interests include wireless power transfer, communication, industrial electronics, and optimization techniques in power system economics and applications.
Chun-Liang Lin was born in Tainan, Taiwan, in 1958. He received the Ph.D. degree in aeronautical and astronautical engineering from the National Cheng Kung University, Tainan, Taiwan, in 1991. He was an Associate Professor and Professor with the Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, from 1995 to 2003. He is currently a Chair Professor with the Department of Electrical Engineering, National Chung Hsing University, Taichung, Taiwan. His research interests include guidance and control, wireless power transmission, and biometrics with applications. He was the recipient of the Distinguished Research Award three times from the National Science Council of Taiwan in 2000, 2003, and 2010, respectively.
Inductive resonance, Magnetic resonance, Quality factor (Q factor), Resonant circuit, Tuned network, Dynamic battery charging system, Emissions, Regenerative brake, Renewable power sources, Static battery charging system.
For more Information, Please visit: https://bit.ly/3eQ72o0


The tool cavities of drop forging presses are in part geometrically so complex that conventional manufacturing methods of spray heads reach their limits. This is exactly where additive manufacturing, also known as 3D printing, reveals its strengths.
Drop forging presses are used, for example, in the automotive industry. The spray head removes scale from the dies, cools the die surface, applies lubricants and dries the dies. But let’s start from the top.
The new additive-manufactured 3D spray heads are based on the same principle as the plate spray heads, which were also developed by SMS group, and incorporate all the advantages of this proven technology: The external-mix two-fluid nozzles produce an extremely fine aerosol. Of course, unmixing, unlike in internal-mix systems, cannot occur with this technology. The homogeneous, constant-over-time spray pattern provides for a long tool service life and optimal spraying results. The nozzles can also be divided into spray zones that can be turned on and off at will over time. To switch the nozzles, SMS group continues to use the tried and proven membrane material of the plate spray heads for the 3D spray heads. The membrane platelets are located directly at the nozzle. The short switching periods allow for high dynamics, but dripping is precluded. Furthermore, zones with different spray times permit optimizing spray medium consumption.
The new 3D spray heads even go a step further: The spray medium can - like the atomizing air - be switched individually and with time offsets at will for each nozzle. The adapted control opens entirely new options in this context. However, the outstanding difference to conventional spray heads is the low material weight and the weight-optimized construction. The 3D spray heads are extremely light-weight. This results in several advantages:
- The low weight of the automation reduces wear
- An improved range of choices results from acquiring a new automation
- The cycle times can be positively affected
The additive manufacture enables different nozzle shapes and orientations. SMS group has developed expertise in producing 3D spray heads, thereby reducing the production time to a minimum. Positioning of the nozzles is highly flexible and determined by the client. The interrupted structure prevents collection of the spray medium on the spray head. At the same time, the 3D spray heads have a low structure height, so the tool cavity can be used in other ways. Heat resistance has been demonstrated during testing. In addition, SMS group is always researching materials for these applications.
The low weight burden during re-fitting ensures fast acceptance of the light 3D spray heads among users. Even a crash will only cause minimal damage. Fast reacquisition minimizes idle periods during production. Spots in which deposits collect do not form due to the flow-optimized canals. Cleaning is in any case a thing of the past because the one part construction of the 3D spray heads does not have joints and, therefore, does not dry out. Due to the one-part construction, the 3D spray heads can also be operated at low pressures of 3 bar and high pressures of 10 bar or higher.
Just like plate spray heads, the 3D spray heads require three medium feeds:
- Atomizing air (about 6 bar)
- Spray medium (about 5 bar, there is the option to switch between cooling water and lubricant mixture)
- Instrument air (about 6 bar)
SMS group offers you an optimal, perfectly attuned 3D spray system consisting of spray technology, 3D spray head and spray automation. The client can select different automation solutions, such as linear spray automation or an industrial robot.
New 3D spray systems can be delivered or legacy spray systems can be retooled for 3D spray heads, even if the existing system doesn’t have instrument air. Regardless of whether it’s a new installation or retooling, SMS group initially surveys the actual situation on site. Based on this survey, an offer is produced that includes the 3D spray head and a standardized connection plate. The standardized connection plate only needs to be installed once and holds the 3D spray heads in different nozzle positions. The client determines the position and properties of the nozzles. With this product, SMS offers its clients another option for increasing productivity without stressing people, material or the environment.


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Brownsville, TX — Since beginning operations in 1965, the use of the Port of Brownsville’s grain elevator was in high demand. Millions of tons of grains like sorghum, corn, seed meal and oats were shipped from the port all over the world.
In a deal that seeks to recapture those glory years, West Plains LLC signed an agreement with the Brownsville Navigation District to modernize and reactivate the grain elevator in support of grain farmers throughout South Texas.
During its meeting Wednesday, May 4, the BND Board unanimously approved the lease, pumping new life into one of the port’s most iconic buildings.
“Farming is part of the DNA of the people of the Rio Grande Valley and many of its residents remember when the port used to move millions of tons of sorghum, corn, and other grain commodities,” stated BND Chairman Ralph Cowen. “We worked really hard to make this project become a reality and I am very pleased to have had the full support of the board as well as the support from the port’s staff who worked diligently to achieve this objective.
“We need to make full use of all of the port’s assets and the grain elevator is one of them. This agreement will be of tremendous benefit to local farmers who will now be able to move their crops via our port and ship it to the rest of the world,” added Cowen.
The lease is structured in three phases, with the primary lease term of 10 years and two 15-year renewal options. The agreement also allows the option to purchase the grain elevator as long as the company fulfills certain requirements within the agreement, including job creation thresholds.
Paul Johnson, director of operations for West Plains, said his company is excited to bring the grain elevator back to business.
“We’re very pleased to be a part of the Brownsville community and the Port of Brownsville,” he said. “The grain elevator is kind of a landmark here at the port, it’s one of the first things you see when you fly into town so we’re very excited to bring it back into production.”
West Plains owns and operates 24 grain elevators across four states: Nebraska, South Dakota, Colorado, and Wyoming. The grain elevator at the Port of Brownsville will be their first facility in Texas.
Johnson said the company looks to bring new markets to local growers, for crops like sorghum and corn. It plans to take full advantage of the port’s strategic location, with direct access to Mexico and other international markets via ocean-going vessels.
“It will take a big undertaking to rehabilitate the facility. There’s a lot of work to be done, but we have a goal set to be able to accept grains this year,” Johnson added.

domain: agronomy


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What is a French Press?
A French Press also known as a Press Pot or Plunger Pot
is an unique easy way to make your coffee. Using
this Process will give you an excellent cup of coffee and
your friends will be amazed watching you prepare and brew
the coffee right at your dinner table. The French Press is
used at the restaurants in the old Colonial Williamsburg,
Virginia. This was the brewing process used back in the
1700's and everything there brings you back to that time.
Colonial Williamsburg brings you back to a time when our
country and Constitution was founded and makes for an
excellent vacation and history lesson. So much for that.
What do I need?
A French Press and a heat source, coffee,
filtered or bottled water preferred. Purchase a French Press
What type of coffee grind?
The French Press uses a medium to coarse grind. The grind
must be large enough so that the mesh filter on the plunger works and does
not get clogged. Because of the larger grind, the brewing
time is a bit longer than with other methods. I use 5
minutes as a general rule but you can adjust the time a
minute or two either way to suite your taste. A grind set
between drip and percolator is a good place to start as it
varies from one press pot brand to another
What else should I know?
Water temperature is vital and doing it correctly
makes a world of difference. You can
make what many say is the perfect cup of coffee buy using
fresh filtered or bottled water. I do not recommend using an
aluminum pot to boil water in. Stainless steel or a Pyrex
glass container is preferred. Ideally,
you want the temperature between 195 and 200 degrees F. One
way to do this is to boil the water and use an instant
read thermometer from any kitchen store. Once you remove the
water from the heat, see how long it takes to reach 200
degrees. It will probably take about 10 to 20 seconds to
cool to the desired temperature. In some
places, your water may boil at the proper temperature of 212
degrees. The elevation does have an effect at what
temperature the warder actually starts to boil. Do not allow
the water to boil more than a couple of seconds. Once you
know the timing, you are all set for your future coffee
the lid and plunger. Use two rounded tablespoons of coffee
for each 8 oz. of water. Note that coffee cups range from 5
to 10 ounces. The press
in the picture above
holds 32 oz. of water, that goes up to the bottom of the
silver band. I use five to six rounded coffee scoops
depending on the coffee beans I'm using that day.
Put the dry coffee into the clean pot.
the proper temperature water, start slowly adding it to the
pot. Most of the coffee will float. You can briefly, gently
stir the water at this point and many grinds will sink.
The screen should be up against the bottom of the
lid. Place the lid on the press. Many lids have a position
that does not allow steam to escape, use this position if
you have it.
After one minute, if you did not stir in Step 2, you can
remove the lid, give a brief stir, and replace the lid.
Now this time depends on your grind so you will need to
practice. Timing from the addition of the water, after a
total of THREE to FIVE minutes you will need to start the
plunge. The finer a grind you use, the shorter the time. I
typically brew for 5 minutes plus or minus 1 minute.
the lid with one hand and carefully push the plunger down,
the screen will push the grinds to the bottom. If the filter
screen is tilted and grinds are escaping, just remove it,
give a quick rinse, and replunge.
It should take about 20 seconds, this is not a fast push,
there is resistance and it gets a bit tougher as you go.
You are now ready to enjoy your
coffee. Just pour a cup and enjoy.
Note: Don’t let the coffee sit in the pot, it will actually
keep brewing. Also, be aware, there will be some grinds in
the bottom of your cup, it is best not to go for the last
French Press - Easiest form of rich flavor coffee brewing
- The French press method is a form of coffee brewing
which involves placing coarsely ground beans into a glass or
ceramic carafe and pouring heated water over the grounds and
letting it steep.
Coffee - No one type and size fits all. -
When it comes to coffee I can truly say:
"No one size or type fits all" because in this coffee
drinking City of New Orleans there are so many different
types of coffee that it will get your head spinning.
Best Espresso Maker
Under $90 -
Don't make the mistake and buy an
espresso maker based strictly on price because more expensive does not
always translate into better product. Pressure rating of 15-bars makes
DeLonghi EC155 Espresso Maker
the perfect choice for your home and priced under $90.
Buying the Right Espresso Machine-Just
as there are many different kinds of espresso flavors and drinks on the
market today, so too are there just as many different ways to make an
espresso beverage. The main difference, however, in making an espresso
base coffee beverage lies in the machine that is used to make it.
What Is Espresso-
Espresso really does have quite a different nature than
other coffees! Not only is espresso a more concentrated cup
of coffee, but the taste is very different as well and may
account for some of the reason why espresso is usually liked
more than coffee.
Magic Brew - How to Make Your Own Espresso
- once you get started making espresso then you will
have not only more control over your own beverage, but
you'll be able to perfect the art of making espresso so that
it comes out the same every time!
Why Should you buy a Home Espresso Machine? - Home
espresso machines are available everywhere and if you are
really passionate about coffee then there is no reason why
you shouldn’t have one in your kitchen. Just imagine waking
up every morning to your home brewed espresso, how would
Espresso - Unbelievable Shock & Awe of Rich Flavor Burst!
- You can believe you are in for an unbelievable flavor and
caffeine shock from the espresso coffee bean with your first
shot of espresso coffee beans.

domain: hobby


text:
Predicting preterm birth based on vaginal microbiota assessment by real-time PCR in the first trimester
Prevention and early diagnosis of gestational complications are crucial for reducing maternal and neonatal mortality rates, as well as for reducing morbidity throughout the rest of their lives . Preterm birth (PB) accounts for estimated 70% of neonatal mortality and 36% of child mortality. Long-term consequences of PB take the form of neurological disorders in children in 25-50% of cases , and therefore, it represents not only a medical, but also a social problem worldwide.
Preterm birth occurs during 22nd to 36th weeks of pregnancy . PB is one of the great obstetrical syndromes, which are characterized by a long preclinical stage [1, 2, 3, 4]. The prevalence of PB in Russia is about 6% of the total number of births . Moreover, in 70–80% of PB cases, the labor occurs spontaneously, and only 20–30% of the cases manifest with early signs from mother and/or fetus [2, 3].
In recent years, a number of the most significant complications of pregnancy (premature birth, placental insufficiency, fetal growth retardation syndrome, and preeclampsia) are increasingly considered as a single group called "the great obstetrical syndromes" [4, 5]. These pathological conditions are based on placental disorders in the early stages of pregnancy, associated with defects in the gestational transformation of spiral arteries, which in turn can be caused by a number of etiological factors (luteal insufficiency, disorders in the formation of immunological tolerance, acquired or congenital thrombophilia, direct or indirect effects of infectious agents) [6, 7]. In clinical practice, as a rule, there is a complex combination of several etiological factors and pathogenetic mechanisms.
The 2020 clinical recommendations on preterm birth management emphasize the scientifically proven relationship between PB and genital tract infections (GTIs). The course of GTIs in most cases is asymptomatic [2, 8]. A change in the microbiota of the genital tract leads to an increase in the contractile activity of the myometrium and degradation of the extracellular matrix with the remodeling of the cervix and amniotic membrane [2, 8, 9].
The structure of genital infections in pregnant women is dominated by vaginal microbiota disorders. More than half of women have at least one episode of genital pathology associated with dysbiotic disorders during pregnancy . At the same time, pregnancy itself is a risk factor for the development of a pathology caused by opportunistic microbiota and microorganisms with weak virulence and aggression factors .
Vaginal dysbiosis is caused by an imbalance between the opportunistic and physiological microflora, the extreme degree of which is pronounced dysbiosis, which definitely requires treatment [12, 13, 14]. The state of vaginal microbiocenosis, where the proportion of lactobacilli is in the range of 20–80% of the total bacterial load (TBL), is regarded as moderate dysbiosis . Whether this option is normal or requires treatment to date remains unclear.
The emergence of quantitative molecular based methods has significantly expanded our understanding of the quantitative and qualitative vaginal microbiota composition in normal and pathological conditions, including pregnancy .
Given the long preclinical stage of PB, development of new prognostic models for this state is crucial. Vaginal microbiota analysis and timely treatment in high-risk women may lead to a decrease in the preterm birth rates and thus improve the perinatal outcomes.
The aim of the work was to develop a mathematical predictive model for assessing the risk of preterm birth based on a quantitative analysis of the vaginal microbiota in the first trimester of pregnancy.
A single-center cohort retrospective comparative study included 199 patients who received prenatal care at the ‘Garmonia' Medical Center (Yekaterinburg) in the period from 2012 to 2021. The study was conducted on the basis of the laboratory department of the ‘Garmonia’ Medical Center.
Inclusion and exclusion criteria
Inclusion criteria for the main group: age from 20 to 42 years, spontaneous preterm birth (28–36 weeks gestation), consent to participate in the study.
Inclusion criteria for the control group: age from 20 to 42 years, term birth, consent to participate in the study.
Exclusion criteria for the main group: severe endocrine diseases; arterial hypertension of 2nd–3rd degrees; thyroid diseases in the decompensation stage; coagulopathy; antiphospholipid syndrome; intrauterine infectious processes during pregnancy; severe chronic diseases (kidneys, liver, respiratory organs, cardiovascular system, central nervous system); mental ilnesses; present or history of oncological diseases; chronic alcohol or nicotine intoxication, substances abuse; uterine malformations.
Exclusion criteria for the control group: refusal to participate in the study, indications for induced preterm birth or preterm surgical delivery, infections of the genital tract caused by obligate pathogens.
Groups of patients
The main group (group 1) included patients with PB (n = 41), the control group (group 2) consisted of women with successful full-term delivery (n = 158).
All participants of the study underwent a clinical and laboratory examination, in accordance with the current standards.
All patients underwent vaginal microbiota analysis by qPCR at 6–12 weeks of gestation (I trimester). The material for the study was collected in an Eppendorf tube containing 1 ml of sterile saline solution from the posterolateral vaginal wall. DNA was extracted using the PREP GS PLUS reagent kit (DNA Technology LLC; Russia), was performed using Femoflor ® 16 REAL-TIME PCR Detection Kit (DNA Technology LLC; Russia) according to the manufacturer's instructions. 16 groups of bacteria were typed and quantified. According to the test results, each vaginal sample was automatically characterized using the software provided by the manufacturer.
The design of the study was reviewed and approved by the local ethics committee of the Federal State Budgetary Educational Institution of the Ministry of Health of the Russian Federation, Protocol No. 7 of 28.03.2011. All participants of the study were informed about the methods and nature of the study, the inclusion of the survey results in the scientific study and signed a voluntary informed consent.
Methods of statistical analysis
Statistical processing of the study results was carried out using computer programs Statistica 7.0 (StatSoft Inc.; USA), Microsoft Excel 2016 and StatPlus:mac 8.0.3 (AnalystSoft; USA). The normality of the distribution was checked using the Kolmogorov–Smirnov criterion. The distribution was not normal. For quantitative indicators, the median value (Me) and the interquartile range (Q1–Q3) were indicated, and the nonparametric Mann–Whitney criterion was used to assess the Statistical processing of the study results was carried out using computer programs Statistica 7.0 (StatSoft Inc.; USA), Microsoft Excel 2016 and StatPlus:mac 8.0.3 (AnalystSoft; USA). The normality of the distribution was checked using the Kolmogorov–Smirnov criterion. The distribution was not normal. For quantitative indicators, the median value (Me) and the interquartile range (Q1–Q3) were indicated, and the nonparametric Mann–Whitney criterion was used to assess the statistical significance of the differences. Absolute and relative values (%) were presented for qualitative indicators, the statistical significance of the differences was determined using the criterion χ2. The strength of the association of the obtained values was estimated in the values of the odds ratio indicator (OR) with a 95% confidence interval (95% CI). The differences were considered statistically significant at p < 0.05. To form the regression equation, which formed the basis of the predictive model, the method of discriminant analysis with the calculation of canonical coefficients of the discriminant function (CCDF) was used. ROC analysis was applied to evaluate the effectiveness of the proposed predictive model.
Clinical and anamnesis characteristics of the examined patients
Initially, the groups were compared according to their medical history parameters. The data of somatic and obstetricgynecological history of the patients were taken into account. The average age of the examined patients was 29.04 ± 4.62 years for the main group and 28.53 ± 4.03 years for the control group (p > 0.05). In terms of weight and height parameters, the differences were not significant (p > 0.05). The frequency of detection of somatic pathologies (diseases of the cardiovascular, urinary, respiratory, nervous systems, endocrinopathies, pathology of the gastrointestinal tract and autoimmune diseases) also did not differ between the groups (p > 0.05). Thus, the groups were clinically comparable.
Vaginal microbiota analysis
Vaginal microbiota composition was assessed by qPCR. In accordance with the previously proposed criteria , 4 variants of vaginal microbiocenosis were distinguished, the frequency of detection of which differed in pregnant women of the analyzed groups (fig. 1).
In the main group, dysbiosis of varying severity was determined in 16 (39.0%) patients, in the control group it was determined in 18 (11.39%) patients (χ2 =17.457; p < 0.001 [2.9E-5]). The detection rates of Ureaplasma spp in an amount of more than 104 genomequivalents in ml (GE/ml) differed significantly: 18 (43.9%) in the main group, 39 (24.7%) in the control group (χ2 = 5.853; p = 0.016). Moreover, in group 1 dysbiosis in combination with Ureaplasma spp. in an amount of more than 104 GE/ml was detected in 11 (26.8%) women, and in the control group — in 6 (3.8%) pregnant women (χ2 = 21.991; p < 0.001 [2.7E-6]). At the same time, detection rates of conditional normocenosis associated with Ureaplasma spp. in the amount of more than 104 GE/ml, did not differ between the groups. Also, there were no statistically significant differences in the detection rates of absolute normocenosis and conditional normocenosis associated with Candida spp.
For the convenience of assessing the risk of PB and the distribution of pregnant women into low- or high-risk groups, based on the results of vaginal microbiota analysis by using qPCR, we have developed a prognostic method with the calculation of the prognostic index PRIMA (Preterm birth. Index of Microbiological Analysis). To develop a prognostic index a discriminant analysis was carried out in the obtained matrices of laboratory parameters for patients of the analyzed groups.
Lactobacillus spp., Staphylococcus spp., Sneathia spp. / Leptotrichia spp. / Fusobacterium spp., Gardnerella vaginalis / Prevotella bivia / Porphyromonas spp., Eubacterium spp., Lachnobacterium spp. / Clostridium spp., Mobiluncus spp. / Corynebacterium spp., Ureaplasma spp were the most significant in predicting the risk of PB. The total bacterial load (TBL) was also taken into account. The data were determined in the Lg GE/ml format.
CCDF are presented in tab. 1.
The PRIMA index is calculated by the following formula:
PRIMA = 0.25 – 0.49 × X1 + 0.74 × X2 – 0.16 × X3 – 0.22 × X4 – 0.04 × X5 – 0.22 × X6 – 0.03 × X7 – 0.03 × X8 + 0.3 – X9, where
X1 is TBL, Lg GE/ml;
X2 is Lactobacillus spp., Lg GE/ml;
X 3 is Gardnerella vaginalis / Prevotella bivia / Porphyromonas spp., Lg GE/ml;
X4 is Lactobacillus spp., Lg GE/ml;
X5 is Sneathia spp. / Leptotrichia spp. / Fusobacterium spp., Lg GE/ml;
X6 is Lachnobacterium spp. / Clostridium spp., Lg GE/ml; X7 is Mobiluncus spp. / Corynebacterium spp., Lg GE/ml;
X8 is Ureaplasma spp., Lg GE/ml;
X9 is Staphylococcus spp., Lg GE/ml;
If the value of PRIMA > 0 — the risk of preterm birth is low, if PRIMA < 0 — the risk is high.
The average PRIMA value in groups 1 and 2 was –0.39 (–1.43 –0) and 0.33 (–0.15 –0.84) respectively. The differences were statistically significant (p < 0.001). Graphically, the value of the PRIMA index is represented by fig. 2.
To assess the effectiveness of the presented predictive model, ROC analysis was performed. The ROC curve for the PRIMA index is represented by fig. 3. The area under the curve (area under curve, AUC) was 0.76 (95% CI 0.68–0.84), which corresponds to the good quality of the predictive model.
To determine the sensitivity and specificity of the presented prognostic method, a holdout sample was used. The sensitivity and specificity parameters were respectively 70.7% and 79.75%, the effectiveness of the method was 77.89% (tab. 2).
Sensitivity and specificity at different values of the PRIMA index are shown in fig. 4.
According to previous studies, the lactobacilli-dominated type of the vaginal microbiota, which is established by the beginning of the second trimester, is the most favorable for the successful course and timely completion of pregnancy . Normal microbiota in such pregnant women, as a rule, persists in the second and third trimesters . In our study, we did not find statistically significant differences in the incidence of absolute and relative normocenosis in the 1st trimester of pregnancy, however, it was shown that severe dysbiosis is a risk factor for preterm birth: in group 1, it was significantly more common.
The presence of various opportunistic microorganisms, especially those associated with bacterial vaginosis, in the vaginal microbiota is prognostically unfavorable . At the same time, treatment of bacterial vaginosis during pregnancy is often unsuccessful, and the proven elimination of G. vaginalis does not reduce the risk of PB due to the presence of other obligate anaerobes with a reduced proportion of lactobacilli . Earlier studies have shown that the presence of Ureaplasma spp in a high titer is a risk factor for PB . In our work, we confirmed these data — in the main group, Ureaplasma spp. in the amount of more than 104 GE/ml was detected significantly more often. Moreover, in group 1, dysbiosis in combination with Ureaplasma spp. in an amount of more than 104 GE/ml was detected in 11 (26.8%) women, and in the control group — in 6 (3.8%) women (χ2 = 21.991; p < 0.001). At the same time, detection rates of conditional normocenosis associated with Ureaplasma spp. in the amount of more than 104 GE/ml, did not differ between the groups. Probably Ureaplasma spp. has the greatest significance in patients with dysbiosis.
Other opportunistic microorganisms have no independent significance, however, together they can form the type of vaginal microbiota, which increases or, conversely, reduces the risk of PB. To effectively predict this condition, a comprehensive assessment is necessary.
Previously, an attempt was made to develop a prognostic model for assessing the risk of PB based on the results of vaginal microbiota evaluation . However, the authors of the proposed method used the NGS sequencing method (the target site of the bacterial genome is the 16S rRNA gene). Despite high informativeness, this approach has a number of disadvantages: complex sample preparation, difficulty in controlling the collection of material, long duration of analysis, difficulty in interpreting the results, high cost of equipment and reagents for research. These disadvantages make it almost impossible to use NGS sequencing in routine medical practice. For this purpose, realtime PCR method is much more convenient.
On this basis, we have developed a method for predicting preterm birth, taking into account data on the qualitative and quantitative composition of the vaginal microbiota of pregnant women obtained using qPCR. The novelty of the proposed method is that for the first time, a highly effective prediction of preterm birth is carried out solely on the basis of the qualitative and quantitative composition of vaginal microbiota. The proposed prognostic PRIMA index takes into account the role of 8 out of 16 determined parameters in the complex vaginal microbial community. It is noteworthy that in addition to G. vaginalis, which is traditionally associated with an increased risk of PB , 4 other groups of obligate anaerobes were significant in the formation of the prognostic index. This fact emphasizes the expediency of a comprehensive analysis of vaginal microbiota with an assessment of the significance of all potentially present microorganisms.
The limitation of this study is the exclusion of clinical and medical history data, as well as the results of other analyses from the number of parameters used to compile a prognostic index. We understand that preterm births cannot be entirely attributed to vaginal microbiota disorders. Therefore, it is possible to increase the sensitivity and specificity of the predictive model by including additional markers.
The predictive model developed by us makes it possible to detect pregnant women at risk of PB early on the basis of a comprehensive assessment of the vaginal microbiota by realtime PCR in the first trimester of pregnancy. The use of the proposed prognostic PRIMA index justifies the need to treat vaginal dysbiosis already in the first trimester of pregnancy to reduce the risks of preterm birth and, consequently, reduce perinatal morbidity and mortality. Distinguishing patients at risk for preterm birth based on the PRIMA index creates prerequisites for the use of already known preventive methods, for example, vaginal micronized progesterone from 22 to 34 weeks of pregnancy. The proposed prognostic method can be widely used in clinical practice, does not require significant additional costs.


text:
In these challenging times, many people are looking for ways that they can give back and help others. Children’s book author, Eric DeSio, wants to do his part to keep kid entertained and learning and offer a resource for parents and teachers and kids to read and learn and pass the time in a healthy and productive way.
The only thing he asks is that you share this opportunity with as many people as you can.
The process is super simple: Go to https://ericauthor.com/portfolio/social-distance-king/ and click on the link that says “Free” and the the complete eBook will be mailed to you.
Why is he doing this?
Eric truly recognizes and appreciates the importance of having an entertaining and healthy distraction at times like this. Currently, battling his way back from a rare inflammatory neurological condition, “Clippers”, that left him hospitalized, unable to walk, and with impaired speech, Eric found himself inspired to write. Eric found his purpose and mission to ‘share stories’ while he was recovering and hasn’t stopped writing since. And now he wants to give back.
We hope you enjoy!

domain: literature