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You possibly can journey the world free of charge by turning into an “Outdoors Agent” or “Group Travel Organizer” for travel companies. This is the third time that we used Dee’s Travel Agency they usually make are group vacation one to recollect. Moreover, the agent ought to mention something in regards to the local weather, especially for those who could be touring with your loved ones. Seaton says reserving through a journey agent sometimes will not value you extra.
There are all the time incentives from totally different travel corporations for agents to promote their product. Contact any of our travel brokers by cellphone, e mail or text – however you like. I am very satisfied with the service of Dee’s travel company. With hundreds of journey brokers to choose from, you will want to discover just the suitable Japan journey agent to your journey.
Make sure you find out exactly how many individuals you need to join the tour so you may journey without cost. Many journey agencies speak with networks of accommodations, airways, and vacationer guide businesses. The airlines have not paid commissions to journey agents for the reason that mid 1990’s.
Taking a flight with a wheelchair is possible on all the major airways so you may e-book your journey on-line. Typical airline meals are composed of various parts relying on the airline class of the passengers. Webjet means that you can browse through and compare cheap flights to America over the following six months with our Deal Finder software. All flights are proven in native time.
Skyscanner simply provides you a list of countries that you would be able to get to using funds airlines from your chosen departure airport. Lauda Air Flight 004 crashed into the jungles of Thailand after the No. 1 thrust reverser inadvertently deployed whereas the aircraft was at 31,000 ft inflicting the plane to plunge to the ground.
Save some money for souvenirs with low cost Delta flights. All airways have confirmed they broke no rules set down by ICAO in relation to which flight-paths they need to have been utilizing and have now confirmed they’re avoiding Ukraine’s airspace all together.
The small airport was fully unable to handle the big number of massive planes. The crew may have saved the plane even within the final seconds had they reverted to primary flight procedures and …
Atlantic Metropolis is for Lovers, sizzling tub lovers that’s. Here are our top picks for the very best Hotel and On line casino Jacuzzi experiences. Be aware: be certain the hotel you are considering has the services you need as not all hotels supply issues like all-inclusive, and what you get for each kind of service might fluctuate from one hotel or nation to another depending on their policies (discover out before making your reservation to keep away from disappointments).
I do not fish a lot but I think it is an effective way to take pleasure in your seashore trip or holiday. One thing you could be assured of when staying in a hotel that boasts 5 stars is that you will receive a first-class service from every member of the crew.
One of the space’s newer hotels, this institution gives its friends free WiFi, an indoor heated pool, health middle, up to date enterprise center, and a compliment breakfast that includes, biscuits, gravy, eggs, waffles, and more. Right now, aware of our heritage of more than 130 years, friends nonetheless sit up for our well-known service standards, that are second to none right here in Australia.
JetAirways India is the most important non-public airline in India and is head quartered in Mumbai. International flight booking has turned rather a lot easier lately with the help of on-line journey portals. The concept is to guide a Flexifare on the same route at a much less busy time when flights are cheaper. We offer a simple navigation system to allow you to see all the data and flight ticket prices you need in your preferred destination.
This worth differs by reserving class. Reserving a flight right now from London to Bali may cost £600, however tomorrow it may very well be £300 on the same airline. Some airways announce special sales to Fb fans as well. Ebook Low-cost Air tickets to any vacation spot internationally.
One can ebook their low cost flight tickets easily with Makemytrip. OUR GREATEST DEALS Airline ticket deals and prices to worldwide destinations are continuously up to date as a consequence of our one-of-a-kind enhanced software engine. has identified five “zones” that travelers could use to find out the perfect time to ebook a ticket.
Now Flight reserving is simple with Makemytrip. Over time, Traveloka has performed the perfect to improve our system in …
So you are going to Sanibel Island, Florida on vacation! This small island off the coast of St. Maarten has a few of the best beaches in the Caribbean, especially at Shoal Bay East and Rendezvous Bay. If in case you have kids with you on a boat trip then be watchful to them and take enough quantity of foods and water with you.
Once parked, you won’t usually need to go to your automotive, so long as you plan on staying inside the city. Our family nearly decided on “we cannot afford to take any more vacations until the youngsters graduate from college” mode when an advertisement on the internet website caught my consideration.
From solar-drenched European city breaks to beach vacations in unique lands, there is a world of goals to discover. Seahaven Beach Lodge: On a fantastic stretch of seashore, Seahaven encompasses a gulf-entrance pool, personal balconies, picnic areas, and barbecue grills.
Are you planning to go to aboard to visit well-known beaches? Long Time period Guests Areas (referred to as LTVAs) which typically cost $forty for a 14 day keep or $a hundred and eighty for a seven month keep. I tell individuals on a regular …


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GEJE Eustaquio's One FC bid ended quick as he bowed to Adriano Moraes in the inaugural flyweight title bout on Friday night in Rise of the Kingdom in Cambodia.
The 25-year-old aspiring lawyer from Baguio tapped out after his Brazilian opponent caught him in a guillotine choke late in the second round of the main event.
It was a tough loss for Eustaquio, who won two straight bouts to earn a title shot. The Team Lakay product lost for the third time in nine bouts.
The 5-foot-5 Eustaquio actually dictated the fight in the opening round as he leaned on his striking prowess, before Moraes turned the game around in Round 2, where the Brazilian managed to pin down the Pinoy and secure the head lock.
Focus now turns to Eric Kelly, who is expected to see action in a featherweight title fight after scoring a sensational come-from-behind submission victory over Rob Lisita in July.

domain: news


Date(s) - 07/20/2018
6:30 pm - 7:30 pm
Mariposa County Fairgrounds
Ferguson Fire: Community Meeting for Wawona and Mariposa
FERGUSON FIRE COMMUNITY MEETING WHAT: The Unified Commanders, US Forest Service, CAL FIRE, and Mariposa County Sheriff’s Office, along with the National Park Service will be hosting a community meeting to discuss the current situation of the Ferguson Fire. Officials will be giving a briefing highlighting the current actions that firefighters are taking on the fire. Current maps of the fire will be available, as well as other handouts. Additionally, agency officials will also be available to answer questions.
DATE: 7/20/18 TIME: 3:00 P.M. – 4:00 P.M.
WHERE: Wawona Community Center 7925 Chilnualna Falls Rd. Wawona, CA 95389
DATE: 7/20/18 TIME: 6:30 P.M. – 7:30 P.M.
WHERE: Mariposa County Fairgrounds – Building A 5007 Fairgrounds Rd. Mariposa, CA 95338
NOTES: If you have questions about the meeting, please call the Ferguson Fire Info Line (530) 377-6221. The community meeting will be live streamed via Mariposa County Sheriff’s Office Facebook page: https://www.facebook.com/mariposacountysheriff/
To sign up for the Mariposa Sheriff’s Office Emergency Alert System visit: https://local.nixle.com/register/
To register for email updates for the Ferguson Fire Information: www.tinyurl.com/fergusonfire
For additional information on returning home after a wildfire, go to: http://www.readyforwildfire.org/After-a-Wildfire/


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Grains have long been a nutritional staple and continue to be an important part of many people’s diets. But as more consumers are looking for ways to lead healthier lifestyles, some are opting to go “grain-free.”
While the popularity of grain-free eating is fueled in part by diets like Paleo and Keto, consumers report a host of other reasons for eliminating grains from their diets. Many consumers looking for ways to reduce inflammation, ease digestion, and help with autoimmune conditions turn to grain-free lifestyles. Others find that eliminating grain from their diets results in more energy, clearer cognition, and an overall better mood.
With more and more consumers adopting this lifestyle, the demand for grain-free snack options is on the rise. Food manufacturers turn to grain alternatives like cassava, almond, coconut, and chickpea flours to formulate snack options. According to Mintel, there was a 134% increase in the launch of bakery products with non-grain flours over a five year period beginning in 2010. The same Mintel report suggests that “grain-free is starting to emerge as the next generation of (and healthier alternative to) gluten-free.”
According to Kim Holman, Marketing Director for TH Foods, “We’re seeing an increased demand for plant-based snack products that complement a grain-free lifestyle.”
This trend has led our talented R&D team to develop new grain-free, plant-based product concepts. We can custom formulate tasty snacks that are paleo-friendly and meet a number of desired claims.
“Grain alternative ingredients like Cauliflower and Cassava are on the rise. They allow us to develop a low-calorie, grain-free snack that still pack a punch with great flavor and crunch,” said Hipolito Sanchez, R&D manager for TH Foods.
Cassava flour, which is derived from the root plant yucca, boasts a number of desirable claims including gluten-free, grain-free and nut-free. Cassava is also mild in flavor and a good binding agent, making it ideal for baking applications, unlike some other non-grain flour alternatives.
Like cassava, cauliflower lends itself to a number of applications where grains are traditional. Cauliflower pizza crust, rice, and gnocchi are just a few examples of the vegetable’s versatility in replacing grains. It can also be used as a base in crackers and other snacks.
TH Foods has developed a number of grain-free snacks using cassava and cauliflower as a base, including three new flavors of grain-free Crunchmaster® crackers.
Contact TH Foods to get started on your next snack innovation.

domain: food


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(Times of India) It is well-known that stem cells exist in adult tissues. The most commonly known stem cell, the bone marrow stem cell, plays the physiological role of generating billions of blood cells per hour while being capable of making copies of itself. Subsequent to the discovery of the bone marrow stem cell in the 1960s by Till and McCulloch, other types of stem cells were subsequently identified in other tissues. For example, the brain contains a stem cell compartment term the “dentate gyrus” which is capable of creating new neurons at a basal rate, with acceleration of new neuron formation during pregnancy or after stroke. Other tissue specific stem cells include those found the in liver, the heart, and the spleen. One common characteristic amongst stem cells is their ability to efflux various drugs through expression of the multi-drug resistance (MDR) protein, as well as preferential state of quiescence in absence of growth factor activation.
One important reason to seek tissue-specific stem cells is that if they could be expanded in large numbers they may theoretically be superior to other stem cell types for therapeutic uses. For example, culture-expanded cardiac specific stem cells are superior to bone marrow stem cells at accelerating healing of the heart muscle after a myocardial infarction. These types of stem cells are actually in clinical trials at present.
The other reason for identifying tissue-specific stem cells is that they may be useful in identifying molecular events that occur in the process of normal tissue changing to cancer. This is of interest because cancer stem cells are believed to originate from tissue-specific stem cells acquiring numerous mutations.
Currently researchers from the Fred Hutchinson Cancer Research Center have identified a tissue-specific stem cell in the breast. The scientists developed genetically engineered mice in which the green marker protein GFP was used to identify only breast cells that express the stem cell phenotype. The findings appeared in peer-reviewed journal Genes and Development.
“Until now, we have not been able to identify stem cells in mammary tissue. They have never been detected before with such specificity. It is extraordinary. You can see these green stem cells under the microscope in their pure, natural state,” said Larry Rohrschneider of the Hutchinson Center.
It was demonstrated that the activity of the mammary stem cells is modulated during times associated with breast growth such as puberty and pregnancy.
“We have found that those transplanted green stem cells can generate new mammary tissue and this tissue can produce milk, just like normal mammary epithelial cells,” said co-author Lixia Bai.
“Identification of the exact stem cell and its location is the first critical and fundamental step toward understanding the regulatory mechanisms of these important cells,” she said.
The technology described in the publication may be useful in isolating and expanding human breast specific stem cells. If these studies are reproducible, it will be of great interest to see whether they still possess ability to home to injured tissue, which to date has been clearly demonstrated in bone marrow stem cells but not with too much clarity with cardiac –specific stem cells or other types of tissue-specific stem cells.

domain: medical


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ORLANDO, Fla. (WOFL FOX 35) - A 9-year-old girl is recovering after she was shot on New Year's Day while leaving church.
Orlando Police responded to Majestic Life Church off of South Kirkman Road after receiving reports of a shooting just after midnight. Upon arrival, officers located the 9-year-old with an apparent gunshot wound to her right arm. Police believe the bullet came from celebratory gunfire, marking the new year. The child was treated at the scene by paramedics and a church supervisor tells FOX 35 that the little girl is doing ok.
A parishioner at the church said he assisted the child after she was struck by the bullet. "My wife and I saw and heard the gunshots, but we weren't sure if they were fireworks or gunshots, and the mother of the girl was screaming, 'Oh my gosh! Oh my gosh! Sshe's been shot!' And she had a wound on her arm," explained Claude Eugene. "I was very upset, because we just came out of the church, and it's a bad way to start the new year, so I was helping out the mother, stopped the bleeding by applying pressure, and the police arrived later on."
Eugene said there was no room for the ambulance to reach the child, because of heavy traffic, so he ended up carrying the girl down the streets so they would have better access for her. "It's tragic," Eugene added, "because now you want justice to be done out there, and it's sad that people are irresponsible shooting guns."
The name of the child wasn't released. Police said they do not have any suspects and the bullet was never found.

domain: sociology


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New Delhi: The first ever global maps of human emissions of carbon dioxide have been created by scientists solely using satellite observations of the greenhouse gas.
Based on data from NASA's Orbiting Carbon Observatory-2 (OCO-2) satellite, scientists from the Finnish Meteorological Institute, Helsinki, produced three main maps that generated with a new data-processing technique and agree well with inventories of known carbon dioxide emissions.
As per NASA, no satellite before OCO-2 was capable of measuring carbon dioxide in fine enough detail to allow researchers to create maps of human emissions from the satellite data alone. Instead, earlier maps also incorporated estimates from economic data and modeling results.
The maps, each centered on one of Earth's highest-emitting regions - the eastern United States, central Europe and East Asia - show widespread carbon dioxide across major urban areas and smaller pockets of high emissions.
(Human carbon dioxide emissions over Europe, the Middle East and northern Africa- Credits: FMI)
"OCO-2 can even detect smaller, isolated emitting areas like individual cities," said research scientist Janne Hakkarainen, who led the study. "It's a very powerful tool that gives new insight."
To be sure their method was correct, scientists compared the results with measurements of nitrogen dioxide - another gas emitted from fossil fuel combustion - from the Ozone Monitoring Instrument (OMI), a Dutch-Finnish instrument on NASA's Aura satellite.
OMI and OCO-2 are both in the A-Train satellite constellation, so the two measurements cover the same area of Earth and are separated in time by only 15 minutes.
The two measurements correlated well, giving the researchers confidence that their new technique produced reliable results.
Human emissions of carbon dioxide have grown at a significant rate since the Industrial Revolution, and the greenhouse gas lingers in the atmosphere for a century or more.
The results appear in a paper titled published November 1 in the journal Geophysical Research Letters.

domain: geography


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Assigned to the 615 Squadron, Royal Air Force August 23, 1940.
On 15th February 1941 the Squadron flew a sweep to the Netherlands. Stewart was shot down in Hurricane I P3231 into the sea off Vlissingen, Netherlands and was reported 'Missing'.
In April 1941 a body was recovered from the sea and was buried in Zeebrugge, Belgium as 'an unknown flyer'. After the war this was found to be Stewart, identified by a Tailor's tab from his tunic.
*Additional information/ service records requested!*
Personal details have been collected from official Service Records and the Commonwealth War Graves Commission website. Some of the additional information has been provided by War Diaries, Libera Me (G.E. Spittael), Polder Fighting (R.W. Catsburg), Veterans Affairs Canada, WW2 Talk, Aircrew Remembered and other sources. The commonwealth-adegem.com website is not responsible for incorrect information.

domain: history


Nov 1998PPT VISIONRequest Info
PPT Vision has introduced its PPT4240, a turnkey, in-tray component inspection system that provides complete inspection for a wide range of semiconductor components. A tray-flipper simplifies inspection of both sides of a component while eliminating individual handling. Offering a resolution of 2.5 µm, the system uses PPT's SMI 3-D technology to achieve speeds over 10,000 pph for complete coplanarity, package and mark inspection. A series of 2-D and 3-D inspection stations operates simultaneously.


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front man Michael Stipe to dub Wagner a “future superstar.” Notable releases include 2010's "Forever Young," 2008's "The Invention Of Everything Else," and ” 2004’s “Love & Other Indoor Games." “My father worked for the EPA, so I moved around like the stereotypical army ‘brat’,” Wagner says. Born in Iowa City, Iowa, Wagner lived in Washington D.C., Indianapolis, and Chicago, before his tenth birthday. After his parents divorce, Wagner, his brother and mother moved to Philadelphia. Growing up in the 80s, he vividly recalls getting his first transistor radio and listening, transfixed, to top forty radio stations in Chicago and Philly, loving everything from Hall and Oates to Phil Collins.
But like James Joyce’s Stephen Daedalus, Wagner finally had his defining, life-changing musical epiphany. “My big brother brought R.E.M.’s Reckoning home from college which immediately woke me up and snapped me out of my Phil Collins stupor,” Wagner laughs. “Hearing ‘So. Central Rain’ for the first time changed everything.” Reveling in bands like the Replacements and the Pixies (Wagner even does a “twisted” cover of the Pixies’ “Here Comes Your Man”), the young songwriter strapped on a Martin acoustic and began playing in bands in high school and later, at Syracuse University. There, Wagner fronted the funky — and popular — local alt.pop band Smoky Junglefrog, opening for majors like the Mighty Mighty Bosstones, the Samples and Dada.
Following the bands’ demise, Wagner moved to New York City and began playing a wide array of clubs like Mercury Lounge, Rockwood Music Hall, Arlene Grocery, Sin-e, and Brownie’s. Read more on Last.fm. User-contributed text is available under the Creative Commons By-SA License; additional terms may apply..
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domain: artistic


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[Show abstract][Hide abstract] ABSTRACT: Anti-HLA antibodies hamper successful transplantation, and activation of the complement cascade is involved in antibody-mediated rejection. We investigated whether the complement-binding capacity of anti-HLA antibodies plays a role in kidney-allograft failure.
We enrolled patients who received kidney allografts at two transplantation centers in Paris between January 1, 2005, and January 1, 2011, in a population-based study. Patients were screened for the presence of circulating donor-specific anti-HLA antibodies and their complement-binding capacity. Graft injury phenotype and the time to kidney-allograft loss were assessed.
The primary analysis included 1016 patients. Patients with complement-binding donor-specific anti-HLA antibodies after transplantation had the lowest 5-year rate of graft survival (54%), as compared with patients with non-complement-binding donor-specific anti-HLA antibodies (93%) and patients without donor-specific anti-HLA antibodies (94%) (P<0.001 for both comparisons). The presence of complement-binding donor-specific anti-HLA antibodies after transplantation was associated with a risk of graft loss that was more than quadrupled (hazard ratio, 4.78; 95% confidence interval [CI], 2.69 to 8.49) when adjusted for clinical, functional, histologic, and immunologic factors. These antibodies were also associated with an increased rate of antibody-mediated rejection, a more severe graft injury phenotype with more extensive microvascular inflammation, and increased deposition of complement fraction C4d within graft capillaries. Adding complement-binding donor-specific anti-HLA antibodies to a traditional risk model improved the stratification of patients at risk for graft failure (continuous net reclassification improvement, 0.75; 95% CI, 0.54 to 0.97).
Assessment of the complement-binding capacity of donor-specific anti-HLA antibodies appears to be useful in identifying patients at high risk for kidney-allograft loss.
New England Journal of Medicine 09/2013; 369(13):1215-26. · 51.66 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Humoral immune responses during heart transplantation may result in antibody-mediated rejection (AMR), which is now taken into account on endomyocardial biopsy (EMB) specimens and ranked according to the pathologic AMR (pAMR) grades of the International Society for Heart and Lung Transplantation classification. This classification might benefit from new immunohistological markers and validation by others biomarkers, namely donor-specific antibodies (DSA).
From the 293 protocol EMBs performed in 113 patients in our institution during a 1-year period for this prospective study, 280 EMB specimens were available with both histology and immunohistochemistry. C4d and labeling of intravascular cells by cluster of differentiation (CD) 68 were performed on paraffin sections. Available sera (n = 150) concomitant of EMB specimens were tested for the presence of DSA. All of the pAMR+ EMB specimens, along with a set of randomized pAMR0 EMB specimens, were immunolabeled for mammalian target of rapamycin (mTOR) effectors, phosphorylated 70 S6-kinase (p70S6K) and phosphorylated S6 ribosomal protein (pS6RP).
AMR was diagnosed in 37 EMB specimens (13.2%): 1 pAMR1(I+), 27 pAMR1(H+), and 9 pAMR2. The proportion of DSA-positive EMB varied according to the pAMR grade, with pAMR0, pAMR1(H+), and pAMR2 EMB presenting 17.6%, 77.3%, and 100% of DSA-positivity, respectively. Among the 30 pAMR+ specimens with available DSA testing and the 30 pAMR0 randomized specimens, mTOR pathway immunohistochemistry showed endothelial cell positivity for p70S6K in 17 pAMR+ EMB specimens (56.7%) and in 1 pAMR0 EMB specimen (3.3%). pS6RP was detected in 8 pAMR+ EMB specimens (26.7%) and in 1 pAMR0 EMB specimen (3.3%).
p70S6K and pS6RP immunohistochemistry afford new markers of AMR on EMB specimens because their expression is correlated with microcirculation inflammation and DSA. The correlation of DSA with pAMR grade suggests that this grading system is valid.
The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation 08/2013; 32(8):769-76. · 3.54 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: BACKGROUND: Rejection of allografts has always been the major obstacle to transplantation success. We aimed to improve characterisation of different kidney-allograft rejection phenotypes, identify how each one is associated with anti-HLA antibodies, and investigate their distinct prognoses. METHODS: Patients who underwent ABO-compatible kidney transplantations in Necker Hospital and Saint-Louis Hospital (Paris, France) between Jan 1, 1998, and Dec 31, 2008, were included in our population-based study. We assessed patients who provided biopsy samples for acute allograft rejection, which was defined as the association of deterioration in function and histopathological lesions. The main outcome was kidney allograft loss-ie, return to dialysis. To investigate distinct rejection patterns, we retrospectively assessed rejection episodes with review of graft histology, C4d in allograft biopsies, and donor-specific anti-HLA antibodies. FINDINGS: 2079 patients were included in the main analyses, of whom 302 (15%) had acute biopsy-proven rejection. We identified four distinct patterns of kidney allograft rejection: T cell-mediated vascular rejection (26 patients [9%]), antibody-mediated vascular rejection (64 [21%]), T cell-mediated rejection without vasculitis (139 [46%]), and antibody-mediated rejection without vasculitis (73 [24%]). Risk of graft loss was 9·07 times (95 CI 3·62-19·7) higher in antibody-mediated vascular rejection than in T cell-mediated rejection without vasculitis (p<0·0001), compared with an increase of 2·93 times (1·1-7·9; P=0·0237) in antibody-mediated rejection without vasculitis and no significant rise in T cell-mediated vascular rejection (hazard ratio [HR] 1·5, 95% CI 0·33-7·6; p=0·60). INTERPRETATION: We have identified a type of kidney rejection not presently included in classifications: antibody-mediated vascular rejection. Recognition of this distinct phenotype could lead to the development of new treatment strategies that could salvage many kidney allografts. FUNDING: None.
[Show abstract][Hide abstract] ABSTRACT: Collapsing glomerulopathy(CG), characterized by collapse of the glomerular capillary loops onto the mesangial stalks is rarely associated to systemic lupus erythematosus (SLE). Recently a genetic predisposition to HIV associated nephropathy (HIVAN) has been shown in Afro-Americans: MYH9 polymorhism in 2008 and then APOL1 variants (G1 and G2 alleles) in 2010 were shown to be strongly associated with HIVAN. We describe here for the first time the association of CG in a young Afro-American female with SLE having a homozygous mutation of APOL1. The clinical history, laboratory findings and immunofluorescence all confirmed a diagnosis of SLE. However, studies for factors associated with collapsing glomerulopathy in other situations were consistently negative. As this Afro-American patient developed a CG, we performed genotyping of APOL1. It was found that she is homozygotic for the G2 allele of APOL1. Despite.
[Show abstract][Hide abstract] ABSTRACT: The incidence of organic renal lesions in patients with end-stage liver disease is unknown. The goal of this study was to make a prospective evaluation of renal histological lesions in a group of unselected patients awaiting liver transplantation.
Sixty cirrhotic patients underwent a renal biopsy via the transjugular route. The potential effect of renal lesions on renal function was evaluated five years after transplantation.
The yield of biopsies enabling satisfactory analysis was 77%, and no major complications occurred. Proteinuria>0.5 g/day was observed in only 8.7% of these patients, microscopic haematuria in 4.3%, creatinine levels>133 mmol/L (1.5mg/dl) in 10.9%, and Modification of the Diet in Renal Disease (MDRD) clearance<60 ml/min in 13.0%. Twenty-five patients (55.3%) had a morphological diagnosis of renal disease, 15 displayed IgA nephropathy and immunofluorescence testing showed that 12 had specific diabetic linear staining for IgG and albumin, of whom seven had associated histological lesions of diabetic nephropathy. Five years after liver transplantation, renal function had significantly deteriorated more in patients with initial diabetic lesions than in those with normal histology or IgA nephropathy alone.
In patients with end-stage liver disease, IgA nephropathy and diabetic lesions were frequently found despite the absence of renal impairment and/or urinalysis anomalies. Our results strongly suggest that severe renal failure develops preferentially in liver transplant recipients with diabetes or carbohydrate intolerance, and that pre-existing arterial lesions may favour the nephrotoxicity of calcineurin inhibitors. Diabetes prior to transplantation needs to be strictly managed and requires a renal sparing immunosuppressive regimen after transplantation.
Journal of Hepatology 05/2012; 57(3):572-6. · 9.86 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Despite improvements in outcomes of renal transplantation, kidney allograft loss remains substantial, and is associated with increased morbidity, mortality and costs. Identifying the pathologic pathways responsible for allograft loss, and the attendant development of therapeutic interventions, will be one of the guiding future objectives of transplant medicine. One of the most important advances of the past decade has been the demonstration of the destructive power of anti-HLA alloantibodies and their association with antibody-mediated rejection (ABMR). Compelling evidence exists to show that donor-specific anti-HLA antibodies (DSAs) are largely responsible for the chronic deterioration of allografts, a condition previously attributed to calcineurin inhibitor toxicity and chronic allograft nephropathy. The emergence of sensitive techniques to detect DSAs, together with advances in the assessment of graft pathology, have expanded the spectrum of what constitutes ABMR. Today, subtler forms of rejection--such as indolent ABMR, C4d-negative ABMR, and transplant arteriopathy--are seen in which DSAs exert a marked pathological effect. In addition, arteriosclerosis, previously thought to be a bystander lesion related to the vicissitudes of aging, is accelerated in ABMR. Advances in our understanding of the pathological significance of DSAs and ABMR show their primacy in the mediation of chronic allograft destruction. Therapies aimed at B cells, plasma cells and antibodies will be important therapeutic options to improve the length and quality of kidney allograft survival.
[Show abstract][Hide abstract] ABSTRACT: Thrombotic microangiopathy (TMA) occurs in IgA nephropathy, but its clinical significance is not well described. We retrospectively examined a series of 128 patients diagnosed with IgA nephropathy between 2002 and 2008 who had a mean follow-up of 44±27 months. In our series, 53% presented with lesions of TMA, acute or organized, in arteries and/or arterioles. Among patients with TMA, 4% were normotensive, 25% had controlled hypertension, and 71% had uncontrolled hypertension. Of those with uncontrolled hypertension, 26% had malignant hypertension. Histologically, the group with TMA had a significantly greater percentage of sclerotic glomeruli and worse tubulointerstitial fibrosis than those of the group without TMA. However, a significant minority of patients had near-normal histology, with minimal tubular atrophy (20%) and/or <20% interstitial fibrosis (24%). TMA rarely occurred in the absence of significant proteinuria. During follow-up, a doubling of serum creatinine or ESRD occurred in all patients with laboratory evidence of TMA, in 42% of those with morphologic evidence but no laboratory evidence of TMA, and in 11% of those without TMA. In summary, lesions of TMA are frequent in IgA nephropathy and may occur in normotensive patients with near-normal renal histology. Although the pathophysiologic mechanisms involved remain undetermined, the current study rules out severe hypertension or advanced renal disease as sole causes.
Journal of the American Society of Nephrology 11/2011; 23(1):137-48. · 8.99 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: In biopsies of renal allografts, arteriosclerosis is often more severe than expected based on the age of the donor, even without a history of rejection vasculitis. To determine whether preformed donor-specific antibodies (DSAs) may contribute to the severity of arteriosclerosis, we examined protocol biopsies from patients with (n=40) or without (n=59) DSA after excluding those with any evidence of vasculitis. Among DSA-positive patients, arteriosclerosis significantly progressed between month 3 and month 12 after transplant (mean Banff cv score 0.65 ± 0.11 to 1.12 ± 0.10, P=0.014); in contrast, among DSA-negative patients, we did not detect a statistically significant progression during the same timeframe (mean Banff cv score 0.65 ± 0.11 to 0.81 ± 0.10, P=not significant). Available biopsies at later time points supported a rate of progression of arteriosclerosis in DSA-negative patients that was approximately one third that in DSA-positive patients. Accelerated arteriosclerosis was significantly associated with peritubular capillary leukocytic infiltration, glomerulitis, subclinical antibody-mediated rejection, and interstitial inflammation. In conclusion, these data support the hypothesis that donor-specific antibodies dramatically accelerate post-transplant progression of arteriosclerosis.
Journal of the American Society of Nephrology 05/2011; 22(5):975-83. · 8.99 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: It is well known that lesions morphologically identical with focal segmental glomerulosclerosis (FSGS) may appear in IgA nephropathy (IgAN). Capsular adhesions without underlying abnormalities in the tuft, often the first sign of FSGS, are frequent in IgAN. In this retrospective study, a new cohort of 128 adult patients with IgAN was used to validate the new Oxford classification system of IgAN, and shown to have highly significant associations with clinical and outcome parameters. We then used these patients to determine the extent to which IgAN could be accounted for in terms of FSGS. Some form of lesion consistent with FSGS, notably hyalinosis and collapsing glomerulopathy, was found in 101 of these patients. No glomerular lesions were found in 16 patients, and 11 had mild lesions not definable as FSGS. Those with FSGS had significantly worse renal survival at 80 months than those without. Comparison of pure forms of FSGS (excluding collapsing glomerulopathy) with cases of FSGS having other glomerular lesions (mesangial hyperplasia, endocapillary hypercellularity, glomerular necroses, extracapillary proliferation) revealed that those with FSGS and other superimposed lesions did significantly worse than cases of pure FSGS at 80 months following diagnosis. Importantly, patients with pure FSGS had relatively poor survival even without other superimposed glomerular abnormalities. Thus, the majority of cases of IgAN can be interpreted as representing one or another variant of FSGS. Hence, interpreting IgAN in terms of FSGS emphasizes the role that podocyte lesions may play in the pathogenesis and progression of this disease.
Kidney International 12/2010; 79(6):643-54. · 8.52 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: IgA nephropathy (IgAN) often shows lesions morphologically identical with those of focal segmental glomerulosclerosis (FSGS). In order to determine the possible role of FSGS in IgAN lesions, we measured glomerular capsular adhesions, often the first step toward FSGS, in biopsies from 127 patients with IgAN, 100 with lupus nephritis, and 26 with primary FSGS. Capsular adhesions with no lesions in the underlying tuft, consistent with podocyte abnormality or loss, were found regularly in FSGS and IgAN, but infrequently in lupus. Fifteen biopsies of patients with IgAN were studied immunohistochemically using markers for podocytes, Bowman's parietal epithelial cells, proliferating cells, and macrophages. Cytokeratins CK-8 and C2562 differentiated normal podocytes (negative) from parietal epithelial cells (variably positive). There was focal loss of the podocyte markers synaptopodin, glomerular epithelial protein 1 (GLEPP-1), nephrin, and vascular endothelial growth factor (VEGF), particularly at sites of capsular adhesions in otherwise histologically normal glomeruli. Cells displaying the parietal epithelial cell markers PAX2 (paired box gene 2) and the cytokeratins were also positive for the proliferating cell marker, proliferating cell nuclear antigen. These cells gathered at sites of adhesion, and in response to active lesions in the tuft, grew inward along the adhesion onto the tuft, forming a monolayer positive for parietal markers and the podocyte marker Wilms tumor protein-1 (WT-1). These cells deposited a layer of collagen over the sclerosing tuft. Thus, all biopsies of patients with IgAN had changes basically identical to those classically described in FSGS. Hence, our study strongly suggests that podocytopathy of a type similar to that in primary FSGS occurs frequently in IgAN.
Kidney International 12/2010; 79(6):635-42. · 8.52 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The clinical importance of preexisting HLA antibodies at the time of transplantation, identified by contemporary techniques, is not well understood. We conducted an observational study analyzing the association between preexisting donor-specific HLA antibodies (HLA-DSA) and incidence of acute antibody-mediated rejection (AMR) and survival of patients and grafts among 402 consecutive deceased-donor kidney transplant recipients. We detected HLA-DSA using Luminex single-antigen assays on the peak reactive and current sera. All patients had a negative lymphocytotoxic cross-match test on the day of transplantation. We found that 8-year graft survival was significantly worse (61%) among patients with preexisting HLA-DSA compared with both sensitized patients without HLA-DSA (93%) and nonsensitized patients (84%). Peak HLA-DSA Luminex mean fluorescence intensity (MFI) predicted AMR better than current HLA-DSA MFI (P = 0.028). As MFI of the highest ranked HLA-DSA detected on peak serum increased, graft survival decreased and the relative risk for AMR increased: Patients with MFI >6000 had >100-fold higher risk for AMR than patients with MFI <465 (relative risk 113; 95% confidence interval 31 to 414). The presence of HLA-DSA did not associate with patient survival. In conclusion, the risk for both AMR and graft loss directly correlates with peak HLA-DSA strength. Quantification of HLA antibodies allows stratification of immunologic risk, which should help guide selection of acceptable grafts for sensitized patients.
Journal of the American Society of Nephrology 08/2010; 21(8):1398-406. · 8.99 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: This study assesses the immunologic, functional, and histologic course of kidney recipients with preformed donor-specific alloantibodies (DSA) receiving deceased donor kidneys according to two prophylactic strategies that have been sequentially applied posttransplant.
The first strategy combined posttransplant quadritherapy/intravenous immunoglobulin (group 1, n=36) and the second added to the above protocol anti-CD20/plasmapheresis (group 2, n=18). All patients had a concomitant evaluation of glomerular filtration rate, protocol biopsies, and DSA mean intensity of fluorescence (MFI) at 3 month and 1 year posttransplant.
Peak and day-0 class-I or II DSAmax-MFI were similar in both groups. The rate of acute antibody-mediated rejection (AMR) was similar in both groups (19.6% vs. 16.6%, respectively). At 1 year posttransplant, group 2 was characterized by lower microcirculation inflammation lesions (glomerulitis+capilaritis score of 1.8+/-0.2 vs. 2.7+/-0.2, respectively, P=0.03), a lower rate of transplant glomerulopathy (7% vs. 38%, P=0.02), and a lower rate of chronic AMR (41.3% vs. 13.3%, respectively, P=0.03). The decline in DSA-MFI from day 0 to 1 year was 44%+/-13% in group 1 compared with 80%+/-8% in group 2 (P=0.02). Finally, the 1-year glomerular filtration rate was 43+/-16 vs. 54+/-16 mL/min/1.73 m(2) in groups 1 and 2, respectively (P=0.04).
This study raises the possibility that a more intensive day 0 prophylactic immunosuppressive strategy combining intravenous immunoglobulin/anti-CD20/plasmapheresis in this high-risk population, despite similar rates of early acute clinical humoral rejection, is associated with significant differences in long-term function and chronic AMR rate. Future prospective randomized studies are needed to assess the best strategies to be applied in light of the pretransplant immunologic risk stratification.
[Show abstract][Hide abstract] ABSTRACT: The relevance of borderline change (BL) and subclinical cellular rejection (SCR) observed in renal transplantation remains to be determined. Several studies have shown in BL and SCR the presence of a Th1 immune response, qualitatively similar to but quantitatively reduced in comparison with infiltrates typical of acute cellular rejection (ACR).
To elucidate the role of regulatory T cells (Tregs) in the local control of the allogenic response, we studied their presence by immunohistochemistry in 24 biopsies with graft dysfunction (12 ACR and 12 BL) and in 16 protocol biopsies at 1 year (eight SCR and eight subclinical BL).
The proportion of Tregs in CD4 T infiltrates was higher in BL and SCR when compared with ACR. Moreover, their presence was correlated with the intensity of interstitial inflammation (r=-0.35, P=0.027, n=40) and with graft function at the time of the biopsy (r=-0.37, P=0.018, n=40).
These data suggest Treg recruitment at the acute phase of the allogenic response, where they could act to diminish the interstitial inflammation and its associated lesions.
[Show abstract][Hide abstract] ABSTRACT: Terminology for posttransplant renal arterial lesions is confusing, with multiple terms being applied, the more common among them being the comprehensive terms, transplant arteriosclerosis and transplant atherosclerosis; endarteritis, for intimal lesions with an inflammatory component; and finally for advanced lesions with or without intimal inflammation, transplant arteriopathy. However, these latter lesions may present the appearance of banal arteriosclerosis, albeit more advanced expected on the basis of donor age. This review explores the distinctions to be drawn among these various descriptive terms.
Cell-mediated arterial lesions due to T-cell cell-endothelial interactions and antibody-mediated lesions, due to antiendothelial cell antibodies, show many common features: myofibroblasts, some of recipient origin, laying down extracellular matrix. However, they differ in that cell-mediated intimal lesions initially have a prominent leukocytic component, usually absent in antibody-mediated lesions. The antibodies most frequently implicated are antihuman leukocyte antigen class I and class 2 antibodies. With the exception of a sometimes more cellular intima and initial absence of dense collagen and elastic fibers, these latter lesions resemble those of arteriosclerosis of aging.
Many instances of lesions designated as transplant arteriopathy are morphologically similar or identical to typical renal arteriosclerosis and could equally be regarded as accelerated arteriosclerosis.
Current opinion in organ transplantation 11/2009; 15(1):11-5. · 3.27 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Septic shock is one of the leading causes of acute kidney injury. The mechanisms of this injury remain mostly unknown notably because of the lack of data on renal histological lesions in humans.
Kidney biopsy was performed immediately post-mortem in consecutive patients who died of septic shock. Comparisons were made with specimens from eight patients who died of trauma on scene and nine ICU patients that died of non-septic causes.
Nineteen septic patients were included, 11 were male, and age was 72 +/- 12 years. Anuria occurred in all patients 2.2 +/- 1.4 days before death. Seven patients had disseminated intravascular coagulation. In all patients we observed (1) acute tubular lesions whose intensity correlated with blood lactate concentration; (2) intense infiltration by leukocytes, mainly monocytic, in glomeruli and interstitial capillaries as compared to controls; (3) presence of tubular cell apoptosis proved by the presence of apoptotic bodies (2.9% of tubular cells) significantly more frequently than in controls and confirmed by TUNEL and activated caspase-3 staining. Arteriolar/arterial thromboses were observed in only 4 of 19 patients, without any association with presence of disseminated intravascular coagulation.
Kidney lesions in septic shock go beyond those associated with simple acute tubular injury, notably capillary leukocytic infiltration and apoptosis. Vascular thrombosis, however, did not appear to play a major role in the majority of patients. The extent to which these lesions are specific to sepsis or are common to all multi-organ failure independent of its cause is yet to be elucidated. Electronic supplementary material The online version of this article (doi:10.1007/s00134-009-1723-x) contains supplementary material, which is available to authorized users.
European Journal of Intensive Care Medicine 11/2009; 36(3):471-8. · 5.17 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: During sepsis, von Willebrand factor (VWF) is abundantly secreted; the main mechanism regulating its size involves specific proteolysis by the metalloprotease ADAMTS-13.
To determine whether ADAMTS-13 consumption due to its binding to, and/or cleavage, of VWF contributes to its decrease during sepsis and whether abrogating or enhancing ADAMTS-13 activity influences sepsis outcome.
ADAMTS-13 activity was evaluated in a model of sepsis induced by cecum ligature and puncture (CLP) in wild-type and Vwf(-/-) mice. Sepsis outcome was studied in those mice and in Adamts-13(-/-) mice. Finally, survival was studied in wild-type mice injected hydrodynamically with the human ADAMTS-13 gene.
In wild-type mice, CLP-induced sepsis elicited a significant ADAMTS-13 decrease, and a strong negative correlation existed between VWF and ADAMTS-13. In Vwf(-/-) mice, CLP also induced severe sepsis, but ADAMTS-13 was not significantly diminished. Notably, Vwf(-/-) mice lived significantly longer than wild-type mice. In contrast, Adamts-13(-/-) mice and wild-type mice were comparable with regard to thrombocytopenia, VWF concentrations, absence of thrombi, and survival. Hydrodynamic hADAMTS-13 gene transfer with the pLIVE expression vector resulted in high and stable ADAMTS13 activity in CLP mice; however, no impact on survival was observed.
VWF secretion is a major determinant of ADAMTS-13 decrease in the CLP model, and plays an important role in sepsis-induced mortality, but the complete absence of its regulating protease, ADAMTS-13, had no detectable impact in this sepsis model. Furthermore, increasing ADAMTS-13 activity had no impact on survival.
Journal of Thrombosis and Haemostasis 02/2009; 7(5):843-50. · 6.08 Impact Factor

domain: biology


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Gallas stays away from Premiership party
Last updated at 08:45 15 May 2006
It was that kind of day as the club joyously staged a victory parade of the Barclays Premiership and FA Community Shield through the streets of west London.
Iceland forward Gudjohnsen is convinced they are here to stay after back-to-back titles.
"It is brilliant and they say everything comes in threes," he suggested before being interrupted by cries from his team-mates of "Eidur, Eidur give us a song".
Thousands of fans lined the streets to greet Frank Lampard, John Terry and Co on the same day Liverpool paraded the FA Cup.
There were a couple of notable absentees, though.
Unsettled defender William Gallas took no part in the parade, although it was stated he has France's World Cup campaign to prepare for.
Coach Jose Mourinho was there at the start, only to mysteriously disappear en route, perhaps for a spot of lunch with Michael Ballack.
Two open-top buses left the Britannia Gate at Stamford Bridge and made their way via the Fulham Road to Hortensia Road.
Then it turned on to Kings Road and New Kings Road before stopping at Eel Brook Common, where groups of supporters had been watching the parade on a giant TV screen.
There the bus stopped with the players happy to sign shirts, balls and memorabilia that were thrown at them.
Speeches were for another day, though. They were just happy to lift the Premiership trophy and scream 'Champions', which got the crowd going.
It was a fitting finale for the club at the top of football's rich list.
Bizarrely, though, it was more about celery than salaries with the vegetable being launched by players and fans alike in a reference to a song traditionally sung at Stamford Bridge.
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Dr. Juan Martinez
Dr. Juan Diego Martinez specializes in Interventional Cardiology, Peripheral Vascular Medicine, Preventive Cardiology and Nuclear Cardiology. Dr. Martinez is working with PVA Cardiology in San Antonio, Texas.
He speaks both English and Spanish.
Education & Training
- Medical School – University of Texas Medical Branch School of Medicine
- American Board of Internal Medicine
- Certified in Internal Medicine
- Certified in Cardiovascular Disease
- Certified in Interventional Cardiology
- Certified in Nuclear Cardiology
- Methodist Hospital
- Baptist Medical Center
- Christus Santa Rosa Medical Center
- Southwest General Hospital
- Metropolitan Methodist Hospital
- Prevention, early detection and treatment of cardiovascular disease, including invasive therapies and medical management.
- Peripheral arterial disease
- Structural heart disease
- Simple and Complex Coronary arterial disease
Fax: (210) 756-6199
Tuesday: 9:00 AM - 5:00 PM
Wednesday: 9:00 AM - 5:00 PM
Thursday: 9:00 AM - 5:00 PM
Friday: 9:00 AM - 5:00 PM
Juan Diego Martinez is on of the most talented young physicians in the practice of interventional cardiology in the Southwestern United States. He has superb diagnostic and clinical care skills, he is attentive to details, and has superb relationships with colleagues, staff and patients.


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Jenny loves to share what she’s reading! Below, find reviews of her favorite reads.
Sweetbitter by Stephanie Danler is a stunning new coming-of-age novel about a young woman who leaves her small hometown for NYC where she lands employment at one of the poshest restaurants in town. The author poetically describes food as an accompaniment to and metaphor for the story. The book begins: “You will develop a palate. A palate is a spot on your tongue wher you remember. Where you assign words to the textures of taste. Eating becomes a discipline, language-obsesses. You will never … [Read more...] about Sweetbitter
“What have I done with my life?” "What do I have time left to do?" "What am I still capable of?" Perhaps these stirrings and unmet longings live within all of us as we approach new stages of our lives. Gerald Marzorati explores this idea in his wonderful new memoir, Late to the Ball. After a gratifying career successfully editing the New York Times Magazine, Marzorati sets out in his late 50’s to learn the game of tennis. He begins to train seriously with a coach. The book is not only about … [Read more...] about Late to the Ball
My daughter, the psychology major and recent college graduate, was fascinated when she first read Helter Skelter a few years ago. Despite the harsh reality of the subject matter, the murders committed by Charles Manson and his followers, there is something darkly intriguing about his cult and the devotion and obedience he engendered in his minions, most of them young, vulnerable girls. I was equally intrigued by Emma Cline’s fascinating and extremely well-told new novel, The Girls, in which … [Read more...] about The Girls
Hope Jahren is a brilliant storyteller. She’ also a scientist who grew up in her father’s laboratory. In essence, her father taught her 42 consecutive years worth of introductory physics and earth science in that lab, nestled within a community college deep in rural Minnesota. Her father loved that lab, and so did she. While her childhood is captured in astonishing, vivid detail--one of the best writers I’ve encountered in a long time--it is her journey to become a female scientist, her love for … [Read more...] about Lab Girl

domain: library


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- This event has passed.
Imagination Friday with Kate DiCamillo and Sophie Blackall
November 12, 2021 @ 1:00 pm - 1:40 pm
Meet Kate DiCamillo and Sophie Blackall as they introduce their highly anticipated new graphic novel, The Beatryce Prophecy, a fantasy about fate, love, and the power of words. Set in a time of war, Beatryce lives in a world where reading and writing are against the law, leading her on a dangerous quest to unseat the king and change that world.
Kate and Sophie share their new book and process of writing and illustrating, invite children to create their own stories, and answer questions.
You must register for the webinar to attend. You will receive a link to join this exciting interaction with Kate and Sophie. Teachers who want to show the webinar live to their classes can live-stream the webinar. The webinar will be recorded. Those who register will receive a link to watch the recording if unable to join us live. You can also return to this event entry to watch the recording.
Host: Kathy Short, Professor of Teaching, Learning and Sociocultural Studies and Director of WOW
Panelists: Kate DiCamillo and Sophie Blackall
Co-Sponsor: Tucson Festival of Books
Kate DiCamillo is one of America’s most revered storytellers. She is a former Ambassador for Young People’s Literature and a two-time Newbery Medalist for The Tale of Desperaux and Flora & Ulysses. Born in Philadelphia, she grew up in Florida and now lives in Minneapolis.
Sophie Blackall is the acclaimed illustrator of more than forty-five books for young readers and a two-time Caldecott Medalist for Finding Winnie and Hello Lighthouse. Born and raised in Australia, she now lives in Brooklyn.
Imagination Fridays is co-sponsored by the Tucson Festival of Books and Worlds of Words/University of Arizona and will occur one Friday a month at 1:00-1:45 pm from September to December with a new author and/or illustrator to introduce a brand new book. Add excitement to Fridays with world-renowned children’s authors and illustrator to promote new books and encourage children as readers, writers, and illustrators.


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PRIMITIVE PILGRIM RAGGEDY ANN DOLL w/ TURKEY
This auction is for a tea dyed hand made Raggedy Ann doll and her hand made turkey. Annie is dressed in a calico burgundy print with lace around the bottom and around her sleeves. Her square collar is felt with primitive stitching all around the outside edges tied on with a bow.
Annie's bloomers are the same fabric as her dress also edged with lace. Her shoes are painted black with laces. Her bonnet is off white the brim is calico with lace . Her hair color is heather yarn ...her eyes are buttons her prim face is stitched. Her hang tag has the word "BLESSINGS". .
Mr Turkey is 8" tall counting his plaid homespun wings. He is tan with a square felt collar.
More items came be found at:


The Diamante Pro Radiale tire is extremely supple and durable thanks to a radial casing to improve the ride quality with a lower rolling resistance compared to the previous model. We were given a set to try out and logged enough miles to get a good feel for these high-performance tires. The Diamante has always been a well performing tire that was overshadowed by the Vittoria Open Corsa models. Not any more though. The Daimante Pro Radiale version ups the performance, making it a competitive alternative to the less robust, more race minded Open Corsa. I was excited to try these tires out because I’m a big fan of radial casings. To understand the advantages of a radial casing it’s important to understand how tires are made. We won’t go into too much detail here, but a video is provided below for your enjoyment.
So why didn’t I show you a Vittoria video? Well the only Vittoria videos online show how a tubular and open tubular (such as the Open Corsa Evo CX) are made. However, those tires are not vulcanized so the process doesn’t represent how a Diamante Pro-Radiale is made. In the construction of the tire carcass, the nylon fibers are mated to the rubber. The orientation of those fibers is crucial to how the tire rides. Most tires have the fibers oriented at a 30-60 degree angle from the direction of rotation. In order for a casing to be called radial, the nylon fibers must be laid up in a near 90 degree orientation to the direction of rotation. This eliminates the fibers from rubbing each other when they are folded over and consequently reduces rolling resistance and makes the tire more supple. In the automotive market, a full radial is so supple that it doesn’t provide enough structure for the rubber so belts are inserted to help the tire hold form, hence the name “steel belted radial.” In the bicycle world the same is true except that adding steel belts defeats the purpose of making a lightweight bicycle tire. Vittoria thus orients the fibers at an 85 degree angle giving the tire enough structure to hold shape under load, but still gaining the benefits of radial technology.
Vittoria also is the leader in thread count for its tire carcasses. The more threads there are the less need for rubber and consequently the lighter the tire is. Diamante Pro Radiale tires have a true 250 tpi (threads per inch) which means that in one layer of fibers there are 250 threads per square inch. This makes the Pro Radiale extremely supple. So supple that Vittoria released it as a 22c and a 24c instead of the more common 23c and 25c. The reason being that a Diamante Pro-Radiale 22c is so supple that it rides like a 23c. The same goes for the 24 in relation to a standard 25.
I was given a set of 22c Diamante Pro-Radiales to try out and can confirm that they are possibly the most supple tires I have ever ridden. I put about 600 miles on the tires and came away very impressed. Everything Vittoria claims about the suppleness of this tire is true. I would even speculate they may be more supple than the Corsa tires, though that is purely subjective on my part. Another side benefit of the Pro Radiale is it’s incredibly light weight. My tires weighed out to 187 grams each. Combined with Vittoria’s own latex tubes, these tires will help your wheels spin up faster than you may be used to. Lastly, 600 miles isn’t enough to thoroughly test a tire’s durability, but I can confidently say these tires are more durable than the Corsa models. The tread is much more resistant to cuts and slashes, as proven by the lack of slits or cuts in my tires. The last time I rode Open Corsa tires they only lasted 4 rides before they had more cuts in the tread than I was comfortable with. That’s not to say the Open Corsa isn’t an excellent tire, it is… for racing. The tread on the Open Corsa is super sticky, so it picks up more road debris, a natural consequence of having more grip. I would say that comparing the GP 4000 S to the Diamante Pro Radiale is a fair comparison. The durability is on par. The GP 4000 S might have a little more grip with its black chili compound, but the Diamante Pro-Radiale unquestionably rides better.
We would encourage anyone who is looking for excellent ride quality to try out the Diamante Pro-Radiale tires. If you ride one of the current crop of wider rims, go with the 24c model. If you are running Mavic Open Pro rims or another 19mm rim, the 22c will give you better cornering. The 24c will work fine if you’re not doing any crits or taking a lot of hard corners at speed. My personal recommendation is a 22c up front for better cornering with a 24c model on the rear to provide extra comfort. Diamante Pro-Radiale tires can be purchased through Art’s Cyclery, and don’t forget that all tires are 20% off with the purchase of a wheelset.


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Classic vintage poster style digital art Influenced by everything from travel posters to matchbooks
and inspired by some of the great commercial artists of the first half of the last century.
Specializing in posters, covers, logos, and lettering for advertising, sales promotion and licensing.
James Carey studied at the London College of Printing, graduating in 2002 with a degree in Graphic Media Design.
James Carey's image making combines traditional draughtsmanship with a modern, graphic approach. James works first by hand, and then digitally finesses the separate layers of found ...
Panczyszyn, Shauna Lynn
Shauna Lynn Panczyszyn is the go-to illustrator for vibrant, hand rendered type and she’s honed her wonderful chalk-board aesthetic down to perfection. Based in Orlando, Florida, her talents go well beyond brilliant lettering. She has a classically trained voice and is also a figure skater. When she’s ...
Simple eloquent illustrations that engage, inspire and entertain. Please email me at firstname.lastname@example.org
Award-winning conceptual illustration
Patrick started his career as a freelance designer after gaining a Degree in Graphics and Illustration with Commendations for Print Making at Kingston University (London) in 1998.
Patrick has done high profile work for global clients including: Transport of London, Cingular, Starbucks, Bacardi, ...


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Renowned Nigerian actress Bukunmi Oluwasina provided insights into her collaborative rapport with fellow actor Lateef Adedimeji, particularly in the context of their roles in the film “Jagun Jagun.”
Having developed a strong on-screen connection over time, the recent remarks made by Bukunmi Oluwasina shed light on the mutually beneficial working relationship between the two actors. In a candid interview, Bukunmi delved into her experiences of collaborating with Lateef Adedimeji and underscored the remarkable synergy they share. This synergy was particularly evident in their performances within the movie “Jagun Jagun.”
Bukunmi Oluwasina accentuated the significance of the on-screen chemistry she shares with Lateef Adedimeji, as well as their profound understanding of each other’s acting styles and nuances. This harmony and understanding translated seamlessly into their portrayals in “Jagun Jagun,” enhancing the authenticity and impact of their performances.
The insights provided by Bukunmi Oluwasina illuminate the depth of their working relationship, underscoring how their shared rapport contributes significantly to the success of their collaborative endeavors. Their ability to connect and synchronize their talents has resulted in compelling and convincing on-screen portrayals, capturing the attention and admiration of audiences.
In her statement, Bukunmi Oluwasina addressed the prevalent discussions surrounding the undeniable chemistry she shares with Lateef Adedimeji. She expressed her belief that when two exceptionally talented actors collaborate, the outcome is always extraordinary and unparalleled. Drawing from her previous experiences of working alongside him on multiple occasions, Bukunmi conveyed her enthusiasm for reuniting with Lateef Adedimeji for their latest project.
Bukunmi Oluwasina emphasized the unique nature of their working relationship, suggesting that their combined talents yield a synergy that greatly enhances their performances. The depth of their connection becomes evident through their on-screen interactions, adding an exceptional layer of authenticity and emotion to their portrayals.
Her mention of a particular scene where Lateef Adedimeji continued to display intense emotion even after the director had called for a cut provides a glimpse into the dedication and commitment both actors bring to their roles. This dedication to their craft not only speaks to their professionalism but also highlights the level of investment they have in creating impactful and genuine performances.
Overall, Bukunmi Oluwasina’s remarks shed light on the chemistry, dedication, and shared commitment that underlie her collaboration with Lateef Adedimeji. Their ability to evoke powerful emotions and create resonant scenes attests to their prowess as actors and their ability to captivate audiences with their exceptional on-screen dynamic.


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Who are we?
The BEST Solutions group is the result of over 40 years combined experience in horticulture, agriculture, waste management and processing operations. We specialise in sourcing the BEST available technologies to provide an outcome that meets if not exceeds our client’s expectations and requirements. Using a combination of technologies from around the world, our detailed and comprehensive approach to provides solutions specifically tailored to improve the achieve the quality of water and soils. Our team has an immense amount of practical experience in the key areas of our biological based products and services both in Australia and internationally.
As the developers behind BEST Solutions research, development and final products, we pride ourselves on delivering the highest quality soil and water conditioners and cleaning products to industry sectors of home, commercial and industrial alike.
What do we do?
The BEST Solutions Group provide natural solutions made from biologically and environmentally sustainable technologies.
Microbes are responsible for utilising the last energy in the ecosystem and providing the elemental building blocks for the next generation of living things. We have embraced these natural systems and have applied the findings to applications in waste water treatment, restructuring of soils, assisting in the process of composting and in the conditioning of water.
Why do we do it?
The core purpose of the BEST Solutions group is to provide beneficial biological, environmentally sustainable technologies and solutions that will naturally improve the environmental outcomes for soil and water.
Our passion is to harness and implement innovative technologies and natural solutions that will assist in putting beneficial biological life back into soil and water.
How do we do it?
We provide biological and environmentally sustainable proven technologies to treat soil, water and waste. This is achieved through a range of patented solutions including unique aeration systems, biological additives and non-toxic cleaning methods.

domain: agronomy


We want to make a website useful for many individuals. Under the brand name Ram Trucks, full-size cargo pick-ups with a frame type of body are produced. There are literally thousands of pages of information and diagrams for your vehicle's model. Cut off the tail to our zip ties. One for the right side, and one for the left side. Go ahead to take a moment to take our 4-pull cover, we'll put it onto our 4-pull end.
These are big vehicles that are made to handle hard work and anything thrown at them. It's going to be this connection that goes right into the tail light. This is tough to do without a wiring diagram to help guide you through your diagnostic procedure. You could be a technician that intends to seek references or solve existing problems. Then we'll push the other end back into the tail light.
You may need to locate a specific color wire and its exact location. We'll connect it using the provided butt connector. A ring terminal, a fuse for the fuse holder, a ground screw. Upon completion you are given full access to view the manual online for your chosen vehicle and access period of 1-year or 4-years. In 1986, the stylistics of the body underwent a slight correction, and in 1988 the engine scale was renewed - the Slant-6 in-line unit was replaced by a 3. Drive - rear or plug-in full.
As a rule, in the case of full-size pickups, this is 500, 750 and 1 thousand kilograms the carrying capacity is increased from generation to generation. Or you are a student, or perhaps even you that simply need to know about Ram Promaster Backup Light Wiring Diagram. Let's take a moment to work with this black wire here. All of our interior panels right here are basically glued to the sheet metal, so what I'm doing i. We'll put the ring terminal on top of that. There'll be two screws here and here, and one at the very bottom right here.
Access to Factory Part Numbers and Labor Times. After some time in the range appeared 8. You might come from an online search engine, after that discover this site. This topic is a lot of individuals searching on the net, as a result we gather photos from numerous trusted sources and understand in their area. The length of the body is from 1 meter 97 centimeters to 2 meters 43 centimeters.
We're actually going to use a factory ground located right here. I'm going to take this t-connector. Trying to find info concerning Ram Promaster Backup Light Wiring Diagram? We'll take our module and run that to the inside as well. Then we'll repeat this process over on the passenger side. Next we'll go ahead and route our green wire over to the other side.
The main family of options for the pickup includes three models - Ram 1500, 2500 and 3500 until 1994, there were four: 100, 150, 250 and 350 , whose graduation depends on the load capacity measured in pounds. What happens inside the module is that it copies the signal that goes into it, and uses battery power to power a trailer through a 4-pull flat trailer connector. Now for our 4-pull wire harness I'm actually going to run it back inside here and down as close to the wall and this corner as possible. Full transcript: Today on a 2014 Ram Pro Master 2500 we're going to review and install the curt t-connector vehicle wire harness for the four pull flat trailer connector. In 2004, a modification with a V10 engine from the Dodge Viper 8. We offer a money back refund on all legitimate complaints should you not be satisfied with the product. This of course is our main wire harness.
We'll use a 10 millimeter socket to remove the nut. In 2012 at the Auto Show in New York debuted the improved Ram 1500 with a modified exterior, improved aerodynamics, a revised power range and the newest automatic transmission TorqueFlite with eight steps. The t connectors are these guys right here. It also comes with a cover for the 4-pull flat connector. Unlike some other products, these are vehicle specific and not generic, nothing is left out. F150 Backup Light Wiring Diagram Ford F Lovely Floralfrocks, size: 800 x 600 px, source: floralfrocks.
Pull it out just enough to where we can run our 4-pull down. Then there's a small wire harness behind the bumper we can attach it too. We'll be working on the driver side first. Find the free Dodge wiring diagram you need and get started repairing your Dodge electrical problems. These two lead it to the module, which gets power from the battery.


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I really appreciated how Dr. Dietz thoroughly explained my dog’s condition and I especially appreciated his home remedy recommendations which will save me money. I truly believe he genuinely cares for my pet’s welfare and now I know why he was recommended! I’ll continue to see him for all our veterinary care and will be telling my friends to see him too!
Dr. Portie is the best! He has been taking care of my dogs for several years. He has been very caring when 3 of my dogs have passed away. Currently I have 2 dogs under his care and appreciate his attention to their needs. He always calls me back the same day when I have questions. I drive from South Austin for him to take care of my dogs.
Dr. Kotzur and his assistant arrived right on time for our farm call. He gave our horses and donkey their vaccinations and a good going over – all the while explaining everything he was doing and why. Afterward we had a good visit and we felt like Dr. Kotzur was very friendly and down to earth. He took the time to answer our questions and didn’t make us feel like he was rushing to get out of here. I highly recommend not only Sunset Canyon, but Dr. Kotzur as well.
I was very impressed with this vet clinic. The vets and staff were all very friendly and informative. I wasn’t pushed to do expensive tests that might not be needed before trying a first line of defense for my dog first. I will definitely be back and I’m glad to have found this clinic!
You guys are great! Especially Dr. Portie and Dr. Pruitt.
My 3 dogs are privileged to have been in the care of Sunset Canyon Veterinary Clinic since we arrived in Austin 4 years ago. Throughout this time we have experienced nothing but outstanding, empathetic and professional treatment. This Vet practice is indeed first class. i would never take my furry ‘kids’ anywhere else. Thank you to all the many wonderful staff members I have interacted with!
Dr. West consistently provides great care to our horse with time to explain everything and answer our questions.
Best Vet I have ever had! Everyone in the office is extremely helpful and professional. i was extremely impressed by the updates and follow-up post surgery for Bisou. It is obvious that you care deeply about your clients and their pets, and prices are always extremely reasonable. Thank you!
You guys are the best. We’re so happy our friend referred you to us. The drive to get to you is substantially longer than we wanted, and we drive past a good 20 vets on the way, but it’s totally worth it. Thor loves all the doctors there and the cost is much more reasonable than Austin vets. Keep up the good work!

domain: pet


The “damning report” of the Auditor General not only reflects the inefficiencies of the ruling Barbados Labour Party (BLP), but also the governance strategy of giving more to the rich at the expense of the poor.
President of the Democratic Labour Party (DLP) Dr Ronnie Yearwood made that charge on Sunday night during a St Philip South branch meeting at Clara’s Bar, Nursery Drive.
“The Auditor General’s Report reflects a transfer of wealth from the poorest to the richest in society because what bad governance entails is that the poorest are often punished by bad governance. The [inefficiency] of this Government is exemplified by the fact that [Minister in the Ministry of Finance] Ryan Straughn could not defend their position . . . . The fact remains that the context is there to discredit the work of an agency that works on behalf of the people of Barbados,” he said.
He admitted that both BLP and DLP administrations had fallen short when it came to the Auditor General’s Report so Government needs to accept the findings and pledge to the country that better will be done. (CLM)


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Longtime Refugio pilot dies in Colorado snowstorm plane crash
Feb. 20, 2012 at 7:04 p.m.
Updated Feb. 20, 2012 at 8:21 p.m.
REFUGIO - A close-knit community is mourning the loss of a longtime pilot who coached people at Refugio County Airport for several years.
Hans Vandervlugt, 75, of Refugio was piloting a twin-engine Cessna 414A carrying five passengers en route to Yampa Valley Regional Airport about 125 miles northwest of Denver on Sunday when the plane crashed in a snow storm.
Vandervlugt and Gaby Humpal, of Corpus Christi, were killed, said Routt County Coroner Rob Ryg.
Also in the plane were Humpal's husband, Scott, and their three children.
The family was on their way to Steamboat Ski Resort.
Vandervlugt's death came as a surprise to James Henry, a former Refugio County commissioner, who knew Vandervlugt.
Henry said Vandervlugt moved to Refugio in 1972.
"We're pretty much shocked with it," Henry said. "He was a real professional pilot."
Vandervlugt flew airplanes and was a flight instructor for more than 50 years at the airport.
This was not the first time Vandervlugt had flown to the ski resort, Henry said.
Vandervlugt's wife, Ruth, who answered the phone at the Refugio airport, did not want to comment on the death.
"It looks like they bumped into some weather phenomenon that was not predicted," Henry added.
According to a 2010 Advocate story about young pilots, Vandervlugt enjoyed teaching younger students because he felt they were aviation's future.
"They're such a rare breed," he said in the 2010 story.
Scott Humpal, a physical therapist, suffered several broken bones. Their sons, 18-year-old Tad and 13-year-old Dillon, also had broken bones.
The family's 10-year-old daughter, Sara, suffered critical injuries and was flown to a Denver hospital.
A snow squall reduced visibility to less than a quarter of a mile just before the crash, Airport Manager Dave Ruppel told the Steamboat Today newspaper.
The newspaper said the plane came to rest in knee-deep snow and airport crews plowed a path to the wreckage for emergency responders.
The airport was closed to incoming traffic until Monday morning.
The National Transportation Safety Board is investigating.


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- Moncton, NB
- Cover Band / Classic Rock Band
- 84 miles from Saint John
Lori R. said “From start to finish, working with Loaded Dice was totally pro. They responded to all of our phone calls and emails quickly and did everything they said…”
In the past year, Classic Rock Bands have sent 1,687 quotes to event planners
Classic Rock Bands rank #69 in popularity out of 546 categories on GigSalad
2,090 Classic Rock Band reviews on GigSalad with an average rating of 4.9 stars
From request to booking, it takes 1.4 days (on average) to hire a Classic Rock Band
Hey Billie Jean, why don't you walk this way like an Egyptian, but be careful because Janie over there's got a gun. Now if you caught all those song drops then a classic rock band should be on the agenda for your party, club, or other event! These cover bands bring back the songs of Led Zeppelin, Bon Jovi, Journey, Aerosmith, and all the other great bands that rocked out back in the 60s, 70s, and 80s. Book one of these great classic rock bands because they're under pressure to make sure you rock out all night long! Search for Classic Rock Bands in Saint John, New Brunswick above.
Please note that these Classic Rock Bands may also travel to Duck Cove, Fairville, Kennebecasis Island, Summerville, Red Head, Bayswater, Mispec, East Riverside-Kingshurst, Rothesay, Clover Valley, Westfield Beach, Carters Point, Fairvale Stn, Morrisdale, Grand Bay-Westfield, Woodmans Point, Garnett Settlement, Upper Golden Grove, Public Landing, Prince Of Wales, Quispamsis, Lower Greenwich, Clifton Royal, South Musquash, Willow Grove, Black River, Long Reach, Upper Loch Lomond, Browns Flat, and Nerepis.

domain: entertainment


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Whether you wish to establish a small business or you want to take your business public, there are numerous steps to follow. These consist of deciding whether you wish to form a corporation or an llc, preparing an operating contract, and drafting the certificate of formation. Goldenwest Diamond Corporation Redwood City Ca Usa.
Articles of company vs certificate of development
No matter whether or not you are forming a restricted liability business (LLC), you will need to file articles of company with the state in which you are forming your service. In the majority of states, filing a short article of company will permit your LLC to start conducting organization as a registered entity in that state. It will likewise supply the legal defenses that an LLC supplies, such as defense from personal liabilities.
Depending upon the state you are in, there might be a couple of different requirements. You might require to offer a service name and a signed up agent. You may likewise require to offer the variety of authorized shares in the business. You might also have to pay a franchise tax. The amount of information you will need to provide may vary from state to state. Some states likewise have an expedited process for a fee.
In order to form an LLC, you will need to provide the name of the LLC, the members of the LLC, the registered agent and the address of the principal office of the LLC. You might likewise have to supply other info such as the number of authorized shares in the LLC.
In addition to the short articles of company, you might need to submit a certificate of registration with the state. This file is similar to the posts of organization, but there are some distinctions. For the most part, you may require to pay a franchise tax for the business. In some states, the certificate of registration may not be needed. You may also require to pay a filing charge. The filing fee will differ by state. In some states, it will cost you as little as $50, while in others it might cost as much as $150.
If you are forming a restricted liability company, you might desire to consider forming a restricted liability collaboration (LLP) instead of an LLC. An LLP can minimize your liability and tax concern, however you will not get the exact same liability protection that a LLC can provide.
There are many advantages to forming an LLC. You will lower your individual liability, but it is important that you keep your business monetary separation in order to safeguard your individual properties. A restricted liability business can also be an excellent way to decrease the quantity of documentation you will need to submit and keep.
There are many advantages to forming an LLC. You will reduce your individual liability, however it is crucial that you keep your company monetary separation in order to protect your personal possessions.
Creating an Operating agreement for a minimal liability business (LLC) is a crucial step in ensuring the success of your organization. It sets the regards to your company ‘s legal structure, governs the internal operations of your company, and secures you from individual liability. Whether you are looking or starting a brand-new business to broaden your existing one, an operating agreement will help you plan ahead.
An operating agreement is a legal contract between the owners of an LLC. The arrangement information how the LLC will run, the regards to its ownership, and the relationship contracts between the members. It is also a tool for developing succession plans in case among the owners passes away.
An operating arrangement is generally 5 to twenty pages long. Depending upon the specific company, this document might include information about the ownership structure, revenue divides, financial information, and the management of the business.
An LLC can be set up like a sole proprietorship, or it can be set up like a partnership. Whether you ‘re starting a service from scratch or looking to broaden your existing company, an operating arrangement will protect your limited liability status.
An operating arrangement is important to every LLC. It also develops the rules for management, and makes sure that the service is run according to the wishes of the owners.
An operating arrangement for a LLC need to consist of information about the members ‘ expenditures and contributions, the manager ‘s duties, and the supervisor ‘s income. It may also consist of a conflict resolution arrangement, which outlines the procedure for handling disagreements. The operating contract is likewise a crucial document that can be utilized to show potential financiers. It can help you think through your business plan and decide on the best method to run your organization.
The members of an LLC report the earnings and losses on their individual tax returns. It is crucial that the members of an LLC understand how the organization will be assigned, and how much of each earnings will go to each member.
Running arrangements can likewise be used to safeguard the restricted liability of members. The agreement may include a liability declaration, which outlines the minimal liability of members. In addition, the contract might also consist of provisions for a right of first rejection. This implies that a member might buy out a departing member, or that the members can offer their interest.
Operating agreements can likewise be utilized to secure the restricted liability of members. In addition, the arrangement may likewise consist of arrangements for a right of very first refusal.
Whether you ‘re new to business or have stayed in business for several years, you need to comprehend the tax ramifications of forming a restricted liability company. There are a number of tax benefits that a LLC can supply. Among these benefits is that it can assist prevent double taxation. It ‘s important to remember that, while you can select to have an LLC taxed as a corporation, most states also treat an LLC as a pass-through entity for earnings tax functions. If you choose this, you ‘ll pay federal income tax on your company ‘ earnings, but all of your income will be omitted from your personal earnings tax.
When you established an LLC, you ‘ll need to create an operating arrangement that describes how your service will be run. This agreement needs to likewise consist of how you ‘ll choose to treat the LLC for tax purposes. If you ‘re running a service that has several members, you ‘ll require to consist of a provision for each member ‘s distributive share of products of LLC residential or commercial property. This is very important due to the fact that you ‘ll need to consider each member ‘s share of LLC items for federal earnings tax functions.
When a member of an LLC works for the company, he or she is considered a staff member. If the member works for the LLC full-time, he or she must pay self-employment tax.
Goldenwest Diamond Corporation Redwood City Ca Usa
LLCs are also qualified for the Qualified Organization Income reduction, which permits you to declare a deduction of 20% of your business ‘ net income. The amount of this reduction is divided up among the members based upon their portion of ownership. The internal revenue service likewise enables you to subtract certain expenses associated with forming an LLC. These expenditures consist of the expenses of registering the LLC, purchasing organization equipment and paying organization lease.
When you have an LLC, you ‘ll need to file quarterly tax payments with the IRS. You ‘ll likewise require to approximate the amount of tax you owe for the year. You ‘ll require to reserve sufficient money to cover the tax liability. If you sanctuary ‘t currently filed a tax return for your business, you ‘ll require to do so prior to the tax due date. A tax specialist can assist you find out what your tax burden will be and prepare the essential paperwork. Goldenwest Diamond Corporation Redwood City Ca Usa.
For tax purposes, you can choose to have your LLC taxed as a collaboration or a corporation. You ‘ll require to file Internal revenue service Form 8832, which informs the Internal revenue service of your decision. Depending upon the kind of LLC you have, you ‘ll need to pay state and regional business taxes, along with company taxes. Some states likewise have a business franchise tax.
In order to form an LLC, you will need to offer the name of the LLC, the members of the LLC, the signed up agent and the address of the principal workplace of the LLC. It ‘s important to keep in mind that, while you can choose to have actually an LLC taxed as a corporation, most states likewise deal with an LLC as a pass-through entity for income tax functions. If you ‘re running an organization that has multiple members, you ‘ll need to consist of a provision for each member ‘s distributive share of products of LLC property. LLCs are also eligible for the Qualified Service Income reduction, which enables you to claim a deduction of 20% of your service ‘ net earnings. These costs consist of the expenses of signing up the LLC, acquiring company equipment and paying business lease. Goldenwest Diamond Corporation Redwood City Ca Usa.

domain: finance


Also found in: Encyclopedia, Wikipedia.
a species found in cases of melioidosis in humans and other animals and in soil and water in tropical regions. New name for Pseudomonas pseudomallei.
a species that inhabits water and soil and causes melioidosis. Infection is spread via contact with a contaminated source and is a predominant disease of tropical climates. The species is a potential agent for bioterrorism. See also melioidosis.
Burkholderia pseudomalleiA gram-negative Pseudomonas-like bacillus found in the environment—e.g., plants, water, and soil of the tropics and subtropics—which is not part of normal human flora, but may be acquired by inhalation or direct inoculation through disrupted skin.
Human disease ranges from asymptomatic to melioidosis, which is characterised by multifocal abscesses, pneumonia, septicaemia and shock. It has a 20–50% mortality rate.
Burkholderia pseudomalleiPseudomonas pseudomallei Bacteriology A Pseudomonas-like bacterium Clinical Ranges from asymptomatic to melioidosis; skin infection and multifocal abscesses, URI, septicemia and shock
Burk·hol·der·i·a pseu·do·mal·le·i(bŭrk-hol-der'ē-ă sū-dō-mal'ē-ī)
A bacterial species found in cases of melioidosis in humans and other animals and in soil and water in tropical regions.
a genus of gram-negative, aerobic, rod-shaped bacteria.
the causative agent of glanders, a disease of horses that is communicable to humans. Previously called Pseudomonas mallei.
the causative agent of melioidosis, a disease of rodents occasionally transmitted to all domestic animal species and humans. Formerly called Pseudomonas pseudomallei.


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Just over 50 counties in Minnesota are still being classified in the D2 severe drought stage, portions of nine counties are currently classified as being in an extreme drought and many crops are being affected. State Ag Commissioner Thom Peterson:
The latest US Drought Monitor Map for Minnesota is showing the far southern edge of Mower County as being in a severe drought, while the rest of the county is listed as being in a moderate drought. The map is also currently showing all or parts of Wabasha, Winona, Olmsted, Fillmore and Houston Counties being abnormally dry, all or portions of over 60 counties throughout the state as being in a moderate drought all or parts of over 50 counties in southern, southwestern, west-central, central, north-central, northwestern and northern Minnesota as being in a severe drought and most or portions of Wadena, Stearns, Hubbard, Beltrami, Clearwater, Marshall, Pennington, Red Lake and Polk Counties in central, north-central and northwestern Minnesota as being in an extreme drought.
Petersen says livestock producers should be thinking ahead about forage needs and recommends crop farmers who anticipate losses reach out to their insurance agents about what needs to be documented.


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When you stop to think about it, Europe is actually pretty small. Look at a World Map and it becomes apparent that you can get from Dublin to Athens quicker than Perth to Sydney. It’s no surprise then that InterRailing has been, and will continue to be, one of the most diverse summer adventures you can have, and on a budget too!
Each year thousands of Irish students pass through USIT’s offices picking up Global or One Country Passes to hop on the European train network and start exploring. We guarantee you it is the cheapest way to have six holidays in one! InterRail routes and passes operate year round but here are five reasons why September is absolutely the best time to get going…
On the continent, September is very much still a summer month with the likes of Italy, Spain, and the Balkan countries are still pumping out high temperatures and glorious sunshine. The further east you go, the hotter it will tend to be with the likes of Budapest and Athens still averaging in the high 20’s. You will literally be chasing the sun across Europe!
We’ve got to be honest here, children and travelling don’t really go together too well. Of course, exceptions abound but I’m guessing if you’re in your early twenties or thirties the priorities are going to be the nightclubs and museums rather than the calibre of kid’s entertainment. Going in September means it’s going to be less crowded as a result, perfect.
InterRailing on a budget is very, very doable as this super cheap route proves and if you go in September you’re officially in ‘off-peak’ season for flights meaning starting and finishing will be even cheaper again.
Speaking as a man who had to stand for nearly four hours on a train from Berlin to Prague in the past, there’s nothing that ruins your InterRail buzz than attempting to get some shut eye like a cow, standing up on a packed train, with no air conditioning and the open windows cruelly out of reach.
July & August is the peak time of the year for InterRailing but it does calm down quite a bit in September, which is especially helpful for getting a cabin on the night trains.
For any of you still making your way through the turbulent times of exam pressure and thesis writing, there is no better way to forget it all for a while; before you have to start worrying about those late-night library sessions again. Plus living life on the continent for even a short time will teach you a thing or two about a thing or two.
Ready to go? Our 15-Day Flexi Passes start at just €200! Book now!

domain: travel


text: I am making a fingerless glove for the first time using the magic loop. Look Mom no double points! The first glove of the pair I made with double points. They told me I would not go back and I think they may be right. The Pattern is Jive Mitts by Colleen Powley, “Funky mitts with an easy mock-cable pattern”. They make think it is easy but I really have to concentrate and count my rows. The pattern calls for 1 hank Blue Sky Alpacas Techno. I think it is a strange yarn for the pattern. It doesn’t really show off the details off that well.

domain: design


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Peace Concert - Solidarity and Unity for One Human Race
From 6:00pm until 8:30pm
At St. Paul United Methodist Church
2500 Montgomery Ave
Interfaith Paths to Peace / 502-777-2714Tonight’s Peace Concert is to promote inter-religious and intercultural music and dialogue for global unity and peace. There are many who seek to divide people of faith – this concert intends to bring us all together as one – regardless of our faith, traditions, or backgrounds. This event is dedicated to our local community refugees.


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Gallant taps Sufjan Stevens for ‘TOOGOODTOBETRUE’
The four-minute track sees both artists flexing their harmonies and serenading that special someone. A tender guitar backs the artists’ lush introduction, leading into a smooth, subtle beat. On the hook, Gallant sings, “I’ll lay down the cards just like the way you fold your arms / Too good to be true,” before Stevens gifts fans with his own verse.
Following his last single “Doesn’t Matter” released in May of this year, “TOOGOODTOBETRUE” serves as the second single off Gallant’s sophomore album titled This Song Does Not Fit. The record also features Sugar — the creator of Steven Universe on the Cartoon Network — on the outro.
Photo credit: Forbes


text: hi. I recently had sex with a new partner, and it turns out that just after we had sex he developed a small reddish/purple "bruise" or "spot" that is slightly raised. He said it feels uncomfortable and he is conscious of it during the day. He went to the doctor, and the doctor said it was probably mechanical and should go away, but a week later the bruise and raised area have not gone down at all. What would cause a symptom like that? Is there an STD or infection visible immediately or within a couple of hours of having sex? Could it be an irritation to a condom?

domain: health


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Television viewers apparently had their fill of football by the time NBC's Sunday Night Football telecast began Sunday night. The Washington-Baltimore match-up attracted 12.56 million viewers, according to overnight Nielsen's -- somewhat below average. The figure was almost half what Fox registered earlier in the evening for its NFL overrun -- 23.45 million. A Hallmark Hall of Fame special, "Front of the Class," competed strongly with the game. Although the drama averaged 11 million viewers during its first hour on Sunday, the ratings climbed with each half hour, peaking with 12.75 million AT 10 30 p.m. for fourth place.
The album is the first in history to chart without selling a single copy.
Earlier this month a twitter campaign asking Disney to make Elsa their first LGBT princess in the ‘Frozen’ sequel went viral.


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Aquableu´s Sweet Orange Vanilla Shampoo’s sulfate-free, moisturizing anti-inflammatory formula cleanses hair with a combination of powerful sweet orange essential oil, vanilla, and Jojoba oil. This shampoo moisturizes brittle hair while soothing an irritated scalp. With its antiseptic and anti-inflammatory properties, it is perfect for those prone to dandruff. Sweet orange oil Infuses the hair with Vitamin C, an essential nutrient for preventing hair loss by strengthening the hair at the roots and stimulating growth.
Water, Sodium Cocoyl Isethionate, Cocamidopropyl Betaine, Sodium Lauroamphoacetate, Sodium Methyl Cocoyl Taurate, Sodium Lauryl Glucoside Carboxylate, Lauryl Glucoside, Sodium Cocoyl Glutamate, Acrylates Copolymer, Coco-Glucoside, Glyceryl Oleate, Caprylhydroxamic Acid, Glyceryl Caprylate, Glycerin, Sweet Orange Essential Oil, Natural Fragrance, Hydrolyzed Keratin, Jojoba Oil, Sodium PCA, D-Panthenol.
Generously apply shampoo to wet hair, concentrating on the scalp. Gently massage into the scalp for a few minutes. Then, apply to mid-hair shaft and ends only for the last couple seconds. Rinse thoroughly and follow with conditioner.

domain: chemistry