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It is the bitterest child that has no empathy for their elders. I fear for the day when those born in the last few decades, growing up in their relatively comfortable domestic suburbia and with no memory of race riots, try to run this country on the pretext that our nation has come to terms with its bigoted past.
America as a whole still grapples violently with both current and historical racial oppression, and in fact its regions and counties are almost ubiquitously inept when handling the subject. Headlines abound involving police violence towards minorities or barrel rolling cops scattering black kids congregating by a pool, and it is not uncommon to hear about disproportionate incarceration rates.
Warrior cop culture is cultivated in poverty, and as anyone who likes to joke about the ghetto knows, black people are more likely to live in the ghetto than white people. A quick explanation of this process from a white boy with an unabridged history book goes as follows.
As slaves, education was unheard of, families were forcibly separated when an owner decided to sell, and owning property was illegal. A century past abolition and the civil rights movement came to address the fact that the black population were still intentionally being given substandard education, families were forcibly separated by an era of police which defined a new low for American self-harm, and what little property had been earned from white America was being foreclosed upon.
Hundreds of years of truly rapacious inhumanity slowly giving way to subtler forms of extortion culminates in the tumult of the Civil Rights Movement. It’s easy to forget how many people were alive when the last state abolished bans on interracial marriage, or how recently people of color won the right to vote.
It defines shortsightedness to believe the disgusting excesses or subtle depravity of bigotry disappear when five out of nine justices rule against racism, or 60 percent of Americans vote for a black president. A majority opinion does not mean that the rest of the country disappears, nor does it mean that there aren’t states that are mostly racist, which the country as a whole has mostly agreed is abhorrent. Further, simply taking an oppressed people and setting them free does not erase the effects of history.
If one does not believe a thing has roots, one will act like a child and pinch the dandelion off where it meets the earth. A thing must be pulled from the roots.
But racism is not simply some historical scar that neo-Nazis look back on with nostalgia. In many states with the largest disproportionality of death sentences, judges are elected on their tough on crime stance, which essentially equals political incentive to put convicts on death row regardless of the strength of evidence. Convicts are disproportionately black, because aggressive cops are disproportionately put into poor neighborhoods, which are disproportionately black for the same socioeconomic reasons ghettos are disproportionately black in South Africa.
The goal of today’s civil rights defenders is not simply to censor bad words, to imply so is juvenile and discredits past struggles as jokes. It is to make sure that prisons are housed by races proportionate to the area, not by giving get out of jail free cards, but by providing an equal education so that black Americans aren’t more likely to be poor. This needs to be achieved not by the occasional president who parcels out a dozen clemencies, but by the retroactive restructuring of a legal system (and intrinsically the policing system) which has dogged the intersections of race and poverty in the form of the war on drugs.
But even if monumental and sincere changes are made, it cannot be said that America will be a post-racial society for generations. It takes centuries for a culture of shame to assimilate fully, for hate and pain to be forgotten, not relegated to a hidden or distorted truth but a thing truly without relevance that can be acceptably forgotten.


Star Tracks: Monday, May 16, 2016 42 years, 2,191 covers and 55,436 stories from PEOPLE magazine's history for you to enjoy
- The Truth Behind Lauren Conrad's Famous Mascara Tears from The Hills
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People Top 5
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- June 16, 2008
- Vol. 69
- No. 23
Tatum O'Neal Busted for Drugs
After Struggling with Sobriety, the Oscar-Winning Actress—and Mom of Three—is Arrested for Allegedly Buying Cocaine
Friends were surprised by the news. "She said she wasn't using," says Peter Bogdanovich, who directed O'Neal in 1973's Paper Moon, for which she won an Oscar at age 10. "She seemed like she was in good shape." The eldest child of actors Ryan O'Neal and Joanna Moore (who died in 1997), O'Neal has said she suffered emotional and physical abuse during her childhood. A rocky marriage and bitter divorce from tennis star John McEnroe followed. In 1995, O'Neal lost custody of their kids, Kevin, now 22, Sean, 20, and Emily, 17, due to her drug use. After numerous trips to rehab, she won joint custody. Now those close to O'Neal—who appears on the FX drama Rescue Me—are hoping the troubled star can bounce back once again. "She's had some tough breaks," says Bogdanovich. "I'm sure she can recover. She's a good girl."
- Reported by K.C. Baker/New York City,
- Paul Chi/New York City,
- Kathy Ehrich Dowd/New York City.
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text:
Overexpression of Prolyl-4-Hydroxylase-α1 Stabilizes but Increases Shear Stress-Induced Atherosclerotic Plaque in Apolipoprotein E-Deficient Mice
The rupture and erosion of atherosclerotic plaque can induce coronary thrombosis. Prolyl-4-hydroxylase (P4H) plays a central role in the synthesis of all known types of collagens, which are the most abundant constituent of the extracellular matrix in atherosclerotic plaque. The pathogenesis of atherosclerosis is thought to be in part caused by shear stress. In this study, we aimed to investigate a relationship between P4Hα1 and shear stress-induced atherosclerotic plaque. Carotid arteries of ApoE−/− mice were exposed to low and oscillatory shear stress conditions by the placement of a shear stress cast for 2 weeks; we divided 60 male ApoE−/− mice into three groups for treatments with saline (mock) (), empty lentivirus (lenti-EGFP) (), and lentivirus-P4Hα1 (lenti-P4Hα1) (). Our results reveal that after 2 weeks of lenti-P4Hα1 treatment both low and oscillatory shear stress-induced plaques increased collagen and the thickness of fibrous cap and decreased macrophage accumulation but no change in lipid accumulation. We also observed that overexpression of P4Ha1 increased plaque size. Our study suggests that P4Hα1 overexpression might be a potential therapeutic target in stabilizing vulnerable plaques.
Coronary thrombosis, induced by plaque rupture and plaque erosion, can cause acute coronary syndromes (ACS) such as unstable angina, acute myocardial infarction, and sudden coronary death . Histopathologically, the plaque vulnerability is enhanced if plaque contains a large lipid-rich necrotic core covered by a thin fibrous cap [2–4]. As the main components of plaque’s fibrous cap, collagen determines the plaque vulnerability [5, 6]. Furthermore, the physical state of collagen can have a great impact on the development of atherosclerotic plaque by interfering with SMCs and macrophages [7, 8].
Prolyl-4-hydroxylase (P4H) plays a central role in the synthesis of all known types of collagens . As an isoenzyme of P4H, P4Hα1 is a rate-limiting enzyme and is essential for collagen maturation and secretion . It has been shown that manipulating expression of P4Hα1 affects atherosclerotic plaque stabilization, while different manipulations of P4Hα1 have different influences on lesional collagen synthesis [11–13].
Shear stress, the force of blood flow on the endothelium, is thought to play a critical role in the pathogenesis of cardiovascular diseases, such as atherosclerosis. Cheng et al.  developed a perivascular shear stress modifier (called a cast) which could induce changes in shear stress patterns in a straight vessel for studying the development of carotid atherosclerotic lesions of stable and vulnerable phenotypes in apolipoprotein E-deficient (ApoE−/−) mice. Using this technique, stable lesions develop distal to the cast under conditions of oscillatory shear stress, whereas vulnerable lesions (containing a small amount of collagen) develop proximal to the cast due to a low shear stress.
In the current study, we tested the hypothesis that P4Ha1, a key factor for regulating collagen, affects the stabilization of shear stress-induced atherosclerotic plaque. Our study data suggested a new therapeutic target candidate to attenuate coronary thrombosis.
2. Materials and Methods
Male ApoE−/− mice (), 8 weeks old, were obtained from Beijing University Animal Research Center. They were housed in standard cages on 12 h light/12 h dark cycle with free access to water and food. All experimental procedures were in compliance with the Guide for the Care and Use of Laboratory Animals, published by the US National Institutes of Health (NIH Publication number 85-23, revised 1985) and Shandong University.
2.2. Shear Stress Modifier Placement and Grouping
All 60 mice were given a high-fat diet containing 0.25% cholesterol and 15% cocoa butter, starting at 2 weeks before surgery. As described previously by Cheng et al. , we used a shear stress cast that imposed a fixed geometry on the right common carotid artery to induce standardized changes in shear stress, which resulted in a gradual stenosis. Sixty mice were randomly assigned to three groups ( in each group): mock group; lenti-EGFP group; and lenti-P4Ha1 group. Two weeks after cast placement, the mice in each group were given a tail vein injection of saline, empty lentivirus (3.5 × 106 TU null lentivirus), or lentivirus-P4Hα1 (3.5 × 106 TU lentivirus containing P4Hα1) transgenic therapy, respectively. The mice were killed at 4 weeks after cast placement. Blood samples were taken before and after injection to detect the levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, and hydroxyproline.
2.3. Immunohistochemistry and Histology
To compare the effect of low shear stress on lesion formation in the three groups, the mice were humanely euthanized at 4 weeks after surgery, followed by transcardial perfusion with phosphate-buffered saline and 4% paraformaldehyde. The right common carotid arteries were carefully stripped and fixed in 4% paraformaldehyde overnight. The tissues were frozen in OCT compound and then cut at 5 μm thickness continuously. The serial cryosections were stained with hematoxylin (Sigma, St. Louis, MO, USA) and eosin (Merck, Whitehouse Station, NJ, USA). The sirius red staining was used for collagen and Oil Red 0 (Sigma) staining was used for lipid-rich lesions. The macrophages were detected with anti-rabbit CD68 (dilution 1 : 100, Proteintech, Chicago, USA) by immunohistochemistry.
2.4. RNA Extraction and Quantitative Real-Time PCR
The carotid artery specimens after low and oscillatory shear stress were pooled for RNA isolation with TriZol (Invitrogen) according to the manufacturer’s instructions. The concentration of total RNA was tested by spectrophotometry and reverse-transcribed into cDNA. The PCR was performed to determine the gene expression using SYBR Green Technology (Bio-Rad, USA), and the housekeeping gene was used as an internal control. The sequences of primers for β-actin were as follows: forward: 5′-TGGAACGGTGAAGGTGACA-3′, reverse: 5′-GGACTTCCTGTAACAATGCA-3′; the sequences of primers for P4Ha1 were as follows: forward: 5′-ATGACCCTGAGACTGGAAA-3′, reverse: 5′-GCCAGGCACTCTTAGATACT-3′. The data were estimated by the method. All experiments were repeated for three times and only the mean value was used for analysis.
2.5. Western Blot Analysis
The right carotid arteries, after low and oscillatory shear stress treatment, were collected for protein extraction. The equal amounts of protein were separated with a 10% SDS-PAGE and transferred to polyvinylidene difluoride membranes (Millipore, Plano, TX, USA). The membrane was blocked with 5% nonfat milk in TBS-T (50 mmol/Tris, pH 7.5, 150 mmol/L NaCl, 0.05% Tween-20) for 2 h at room temperature and then washed in TBS-T 3x for 10 min. After wash, the blots were incubated overnight at 4°C with an appropriate primary antibody. The membranes were then washed with TBS-T and incubated with horseradish peroxidase-conjugated secondary antibodies for 2 h at room temperature. After 3 washes in TBS-T, the membranes were visualized with ECL plus reagents (Millipore, Plano, TX, USA).
The primary antibodies used in the experiments were goat anti-P4Hα1 (1 : 500, Abcam, Cambridge, UK), rabbit anti-TGF-β1 (1 : 500, Proteintech, Chicago, USA), and rabbit anti-β-actin (1 : 1000, Cell Signaling Technology, Boston, MA, USA).
2.6. Statistical Analysis
All data are expressed as mean ± SD. SPSS for Windows, and version 16.0 (SPSS, Chicago, IL, USA) was used for statistical analysis. When comparing more than two groups, one-way ANOVA was used and the least significant difference test to further compare the two groups for significant differences. A group difference was considered significant when .
3.1. TC, TG, LDL-C, HDL-C, and Hydroxyproline Concentrations
During the experiments, one mouse in the mock group and two in the lenti-P4Ha1 group died. Thus, the sample sizes were 19, 20, and 18 for the three groups, respectively. The body weight and level of serum lipids did not differ between virally transfected and sham mice (, Table 1). However, the level of hydroxyproline in lenti-P4Hα1 group was much higher than the other two groups (, Table 1). Therefore, empty lentivirus or lentivirus-P4Ha1 had no significant effect on lipid levels in the circulation system, suggesting that diet or lipid levels did not appear to play a role in the atherosclerotic lesion differences between the three groups.
3.2. Overexpression of P4Ha1 Increased Plaque Size
To test our hypothesis that altered collagen contents by P4Ha1 overexpression affects the development of atherosclerotic plaque, we studied the development of carotid atherosclerotic lesions of vulnerable and stable phenotypes induced by a perivascular cast . Using this technique, stable lesions develop under oscillatory shear stress, whereas vulnerable lesions develop under low shear stress. The lesion size under low and oscillatory shear stress was increased in lenti-P4Hα1 mice (, Figures 1(a) and 1(b)).
To determine the transfection efficiency of lentivirus-P4Ha1 in mice, we measured the expressions of P4Ha1 in different regions using RT-PCR and western blot. The mRNA and protein expressions of P4Hα1 were higher in lenti-P4Ha1 mice than in mock or lenti-EGFP mice (, Figures 1(c) and 1(d)).
3.3. Collagen Content Was Increased in P4Ha1-Overexpressed Plaques
The role of collagens in atherogenesis is double-edged. That is, defective fiber assembly or degradation can cause plaque rupture and subsequent thrombosis, whereas an excessive collagen production can promote plaque growth and thereby contributes to vascular stenosis . We measured the thickness of fibrous cap and collagen content in shear stress-induced carotid plaques. Sirius red staining showed that P4Hα1 overexpression increased the thickness of fibrous cap and collagen content in both low and oscillatory shear stress-induced carotid plaques as compared to controls (, , Figures 2(a), 2(b), and 2(c)). Furthermore, we failed to find any difference between two control groups, that is, mock and lenti-EGFP mice.
Transforming growth factor beta-1 (TGF-β1) is known to be a major profibrotic cytokine that plays a critical role in matrix remodeling and collagen synthesis . To determine whether TGF-β1 plays a role in atherosclerotic plaque formation in conjunction with lenti-P4Ha1 treatment, we measured the expression levels of TGF-β1 in carotid plaques using western blot. The protein expressions of TGF-β1 were higher in lenti-P4Ha1 mice than in mock or lenti-EGFP mice (, Figure 2(d)).
3.4. No Difference of Lipid Accumulation in P4Ha1-Overexpressed Plaques
Lipid retention is another essential process in atherosclerosis development , and Type I collagen can influence LDL-retention . Oil Red 0 staining was used to measure the lipid content in the shear stress-induced plaques. However, the lipid accumulation did not differ among all three groups (, Figures 3(a) and 3(b)).
3.5. Overexpression of P4Ha1 Reduced Macrophage Infiltration
As macrophages play an important role in the progression of atherosclerotic plaque [19, 20] and can promote formation of unstable plaques by maintaining proinflammatory microenvironment , we investigated the infiltration of macrophages in plaque tissues by being stained with macrophage marker CD68. Compared to controls, overexpression of P4Hα1 significantly reduced the expression of CD68 in both low and oscillatory shear stress-induced carotid plaques (, Figures 4(a) and 4(b)). However, there were no significant differences in expression of CD68 between two control groups, that is, mock and lenti-EGFP mice.
Shear stress, particularly the low and oscillatory shear stress, is widely assumed to play a crucial pathophysiological role in coronary atherosclerosis. Recent studies  have revealed that patterns of shear stress can affect the size and phenotype of the lesions. In animal models, atherosclerotic plaques induced by low shear stress appear to be a vulnerable phenotype. As a rupture of the vulnerable atherosclerotic plaques is the major cause of mortality in humans, our animal results may have a strong implication on the pathogenesis of coronary atherosclerosis. In particular, we for the first time demonstrated that P4Hα1 overexpression affected the size and composition of shear stress-induced plaques.
Collagens are the most abundant constituent of the extracellular matrix in atherosclerotic plaques and play a crucial role in keeping the atherosclerotic plaques intact and stable. P4Hα1, which is essential for collagen biogenesis, plays a central role in the synthesis of all known types of collagens [9, 10]. P4Hα1 catalyzes the formation of hydroxyproline that is required for folding newly synthesized procollagen polypeptide chains into stable triple helical molecules [22, 23]. Our previous works [11, 12] have shown that P4Hα1 expression decreases gradually during the pathological course of atherosclerotic plaques and the decreased expression of P4Hα1 correlates with atherosclerotic plaque instability. In the present study, we attempted to elucidate a relationship between an enhanced level of lesional P4Hα1 and shear stress-induced atherosclerotic plaques in ApoE−/− mouse. We used a slow viral vector that successfully delivered P4Hα1 gene into the atherosclerotic plaque as demonstrated by enhanced mRNA and protein expressions of P4Hα1 and an increase in plasma level of hydroxyproline in lenti-P4Hα1 mice.
Previous studies  have suggested that plaque stability depends upon the plaque composition and state of the fibrous cap. The tensile strength of the intima increases as a rupture of the fibrous cap occurs. The ability of the atherosclerotic plaques to resist mechanical tensile force increases as the collagen component in plaques increases, whereas an increase in the lipid component reduces the plaques’ resistance to mechanical tensile force. Therefore, the ratio of lipid to collagen content is a useful index for evaluating plaque stability . Here, we found that overexpression of P4Hα1 increased collagen content in both low and oscillatory shear stress regions. Interestingly, we failed to find any change in lipid accumulation. As such, overexpression of P4Hα1 appeared to decrease the ratio of lipid to collagen in both low and oscillatory shear stress-induced plaques. In addition, macrophages play a pivotal role in atherosclerotic plaque destabilization [26, 27]. Increased macrophages infiltration is a hallmark of atherosclerotic plaques prone to acute complications . Our data suggested that overexpression of P4Hα1 could significantly decrease the accumulation of macrophages in both low and oscillatory shear stress-induced plaques.
The lesional fibrous cap is an important factor of stability of atherosclerotic plaques. The lesional fibrous cap mainly consists of Types I and III collagens. We showed that lentivirus-mediated overexpression of P4Hα1 increased the collagen content and thickened the fibrous cap in low and oscillatory shear stress-induced plaques.
In addition, we found that overexpression of P4Hα1 increased the size of the atherosclerotic plaques formed in both low and oscillatory shear stress regions. To the best of our knowledge, this was the first evidence that P4Hα1 overexpression regulates the process of atherogenesis under low/oscillatory shear stress. That is, overexpression of P4Hα1 appeared to accelerate atheromatous plaque formation in the ApoE−/− mice. These findings are consistent with our previous results , where overexpression of P4Hα1 accelerated aortic lesion formation in ApoE−/− mice. It is noteworthy that previous studies did not elucidate a relationship between P4Hα1 and atherosclerotic plaques formation under shear stress.
Transforming growth factor beta-1 (TGF-β1) has an essential role in atherogenesis [29–31]. Some studies have shown that TGF-β1 could accelerate atherosclerosis by increasing extracellular matrix (ECM) accumulation [32, 33]. In the present study, we showed that overexpression of P4Hα1 increased the level of TGF-β1 in carotid plaques. We speculate that elevated expression of TGF-β1 in atheroma lesions may be partly correlated with plaques growth in ApoE−/− mice with P4Hα1 overexpression. Thus, overexpression of P4Hα1 promotes fibrosis via increasing the collagen content and possibly ECM accumulation in shear stress-induced plaques. However, whether increasing atheroma fibrosis would be beneficial or detrimental still needs to be determined. On the one side, enhanced fibrosis would stabilize the plaque with a high extracellular matrix content, which may help to reduce plaque vulnerability and make plaque rupture less likely. On the other side, enhanced fibrosis augments plaque size, which leads to vascular stenosis and an increased likelihood of clinical symptoms of atherosclerosis. Therefore, increasing atheroma fibrosis shows a double-edged sword effect on atherogenesis.
From a therapeutic standpoint, our results have a clinical implication on treating shear stress-related atherosclerosis. Modulating the expression of P4Hα1 appears a novel approach to increase the stability of atherosclerotic plaques. Our previous studies  showed that downregulation of P4Hα1 by IL-6 destabilizes atherosclerotic plaques, while upregulation of P4Hα1 by adiponectin increases collagen production that lowers the vulnerability of plaques . Together with our current results, P4Hα1 overexpression appeared a potential therapeutic target to stabilize vulnerable plaques. But future studies are needed to determine how to prevent vascular stenosis due to an excessive collagen production.
In summary, our study identified that overexpression of P4Hα1 may increase the stability of shear stress-induced plaques in ApoE-deficient mice. This result provides supporting evidence that P4Hα1 overexpression might be helpful in designing novel therapeutic strategies to stabilize shear stress-induced atherosclerosis.
The authors have declared that no competing interests exist.
Xiao-qing Cao and Xin-xin Liu contributed equally to this work.
The study was supported by grants from the National Basic Research Program of China (973 Program, 2011CB503906) and the National Natural Science Foundation of China (nos. 81270404 and 81470559).
P. Annunen, H. Autio-Harmainen, and K. I. Kivirikko, “The novel type II prolyl 4-hydroxylase is the main enzyme form in chondrocytes and capillary endothelial cells, whereas the type I enzyme predominates in most cells,” The Journal of Biological Chemistry, vol. 273, no. 11, pp. 5989–5992, 1998.View at: Publisher Site | Google Scholar
K. Zhang, X.-Z. Huang, X.-N. Li et al., “Interleukin 6 destabilizes atherosclerotic plaques by downregulating prolyl-4-hydroxylase α1 via a mitogen-activated protein kinase and c-Jun pathway,” Archives of Biochemistry and Biophysics, vol. 528, no. 2, pp. 127–133, 2012.View at: Publisher Site | Google Scholar
E. P. Amento, N. Ehsani, H. Palmer, and P. Libby, “Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 11, no. 5, pp. 1223–1230, 1991.View at: Publisher Site | Google Scholar
R. B. Wesley II, X. P. Meng, D. Godin, and Z. S. Galis, “Extracellular matrix modulates macrophage functions characteristic to atheroma—collagen type I enhances acquisition of resident macrophage traits by human peripheral blood monocytes in vitro,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 18, no. 3, pp. 432–440, 1998.View at: Publisher Site | Google Scholar
K. Zhang, X. Meng, J. Kong et al., “Simvastatin increases prolyl-4-Hydroxylase α1 expression in atherosclerotic plaque and ox-LDL-stimulated human aortic smooth muscle cells via p38 MAPK and ERK1/2 signaling,” Journal of Molecular and Cellular Cardiology, vol. 65, pp. 43–50, 2013.View at: Publisher Site | Google Scholar
S. Redondo, E. Ruiz, C. G. Santos-Gallego, E. Padilla, and T. Tejerina, “Pioglitazone induces vascular smooth muscle cell apoptosis through a peroxisome proliferator-activated receptor-γ, transforming growth factor-β1, and a Smad2-dependent mechanism,” Diabetes, vol. 54, no. 3, pp. 811–817, 2005.View at: Publisher Site | Google Scholar
P. J. Little, L. Tannock, K. L. Olin, A. Chait, and T. N. Wight, “Proteoglycans synthesized by arterial smooth muscle cells in the presence of transforming growth factor-β1 exhibit increased binding to LDLs,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 22, no. 1, pp. 55–60, 2002.View at: Publisher Site | Google Scholar

domain: literature


Download ThinkRF R5500/R5550 firmware v1.6.6 in the attachment.
Refer to the instruction here for how to do a firmware update.
This document describes version 1.6.6 of the firmware for the ThinkRF R55x0 family of real-time
spectrum analyzers. It is distributed as a single binary file, ThinkRF_R55x0_firmware_v1-6-6.img.
This version of the R55x0 firmware is compatible with all ThinkRF R55x0 products, including R5500
(all models) and R5550 (all models).
1. Added support for new R5550-*-WBIQ products.
Known Issues and Limitations
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text:
After SZA created the drums-drenched, reggae-tinged song Consideration, she thought she had finally found the sound of her debut album. But there was one problem: Rihanna heard the song and wanted it.
“And I’m just like, ‘It has a video. I shot a video already to it. It’s coming out on Wednesday. That was going to be the first song to prep the album,’” SZA recalled in a recent interview.
Rihanna kept SZA as a featured artist on the track, which opens her critically acclaimed Anti album, released last year. And while SZA said recording with the pop star “was a learning experience, it was just dope” — as for her own project? She felt lost. She cried like a baby. She was devastated. She had never given away something she cared so much about.
“I was crying [and thinking], ‘I’ll never make anything better,’” said SZA, now 28. “And Kendrick [Lamar] was like, ‘Well, this is what separates great people. Because great people make better things than that.’”
SZA proved herself to be great — and also proved her earlier prediction wrong.
The songs that make up Ctrl, her major-label debut released in June nominated for five Grammy Awards, have resonated with fans around the world, making SZA both a critical darling and a commercial success. The album is at the forefront of the alternative R&B movement, with SZA earning praise for her vocal delivery and direct lyrics that both female and male fans vibe to.
“My favourite game to play at her shows is finding the tough guy, the straight dude who doesn’t want to show no emotion, and as soon as his song comes on, he loses his mind,” said Terrence “Punch” Henderson, the co-president of independent record label Top Dawg Entertainment, home to SZA and Lamar.
“She’s the voice of this generation right now,” he added. “The words she’s saying is honest and raw [and] she’s speaking for these girls and also these guys.”
On some of her songs, SZA fires off her lyrics more like a rapper than a singer — switching topics quickly as she talks about having sex, failed relationships, persevering in life and if being herself is enough.
“I’m so ashamed of myself think I need therapy,” she even sings on Normal Girl.
The hit The Weekend is about sharing a boyfriend and SZA wonders if her body type is enough for her lover on Garden (Say It Like Dat). She asks for “another Valium” on Love Galore, where she also sings, “Why you bother me when you know you got a woman?”
Issa Rae was such a fan that the actress and producer used much of Ctrl in the second season of her acclaimed comedy series Insecure on HBO.
“SZA’s album is so good and just even thematically for season two, it’s so odd that we could literally put the whole album in,” said Rae. “If I get a cut of an episode and the music isn’t right, it takes me out of it. I’ll be like, ‘This episode is trash.’ [Music] really guides so much of the feel of the show and it has to be perfect.”
Ctrl, which has achieved gold status, has launched two platinum singles with Love Galore and The Weekend, recently remixed by Calvin Harris. The project was named the No 1 album of the year by several critics, including Time, Vice, New York Daily News and The Associated Press; it was ranked No 2 by the New York Times, NPR, Pitchfork and Billboard.
The success makes SZA, who appeared in an ad for Rihanna’s ultra-successful Fenty make-up line, the belle of the Grammys — she’s the most nominated female act.
“You know what’s crazy? I feel like you’re never as good as people say you are. And you’re never as bad as people say you are. So, it’s like, you just gotta take it like with a grain of salt. Like, it’s an experience. A responsibility more so. I think it’s like a knock on the head. Like, you have a responsibility, you have a purpose, so it’s like, uh, get to work and focus,” she said.
SZA’s nominations include best new artist and best urban contemporary album for Ctrl. Three of her songs also earned nominations — the Travis Scott-assisted Love Galore (best rap/sung performance); the fan-favourite The Weekend (best R&B performance); and album opener Supermodel (best R&B song).
But music didn’t almost happen for SZA, born Solana Rowe in St. Louis but raised in New Jersey.
“I had no idea. I just really wanted to be a scientist or just, like, do something like a gymnast... Then I wanted to be in fashion marketing. I really wanted an office, badly. Needed an office. Needed a corner. Needed, like, the wood grain. Needed the good view. Needed the long lunch. Like, I needed all that,” she said. “I just wanted to wear power suits. And like, you know, hair slick, skin immaculate. Like, you know, you always crave what’s the hardest for you to attain.”
“So the music thing I just stumbled on, that was not my plan at all,” she added. “I fought this hard. Like, I fought this whole process so hard. I’m even fighting it now... But it’s getting easier... I’m accepting. I’m accepting where I am. And this is true direction.”
Punch first met the big-haired SZA in 2011 at a Lamar show in New York. SZA was helping sell merchandise but they didn’t have his size. When she arrived in the lobby of Punch’s hotel to bring him clothes, he overheard the music blasting out of headphones of SZA’s friend.
It was SZA’s song.
“SZA got all embarrassed. She wasn’t going to say anything about singing,” said Punch, who co-wrote four songs on Ctrl and is nominated alongside the singer for best R&B song. “I heard her voice and her voice was so distinctive, and then I heard what she was actually saying. I’m like, ‘Yo, she is like a lyricist.’”
That song was one of the first SZA recorded. They kept in touch, she let him listen to more songs and he would give her advice. After two years, she asked Punch to manage her.
“We really talked about it seriously and here we are,” he said.
SZA, who recently won two Soul Train Awards and is nominated for four NAACP Image Awards, is now looking ahead to the Grammys. She plans on bringing her grandmother to the event, to be held in New York City on January 28.
“She’s getting her outfit ready,” SZA said of her grandmother, who lives in St. Louis and is heard giving feisty advice and words of encouragement to SZA, along with the singer’s mother, throughout the “Ctrl” album.
“She’s 90, and this is the one time that the Grammys is near my hometown,” she said. “I’m thankful.”

domain: entertainment


text:
The Millaray Montessori workshops in Puerto Vallarta are a great training complement for children of all levels.
Evening workshops with small groups.
Cultural and social activities
Being a Humanist school, we seek the development and awakening of consciousness in our children. Throughout the school year we carry out different activities that promote social skills, a sense of belonging and self-confidence in them.
We seek harmony and integration as a Millaray community between parents, students and teachers.

domain: sociology


Turkish Defense Minister Fikri Işık has announced that there will be a new expulsion of officers in the Turkish Armed Forces (TSK) and that an upcoming meeting of the Supreme Military Council (YAŞ) will be the opportunity to carry this out.
Speaking to TRT Haber on Tuesday, Işık said: “We will never show any tolerance for the individuals we have found out to have links [with terror organizations]. YAŞ is an opportunity for this, both for an extension of duty and for retirement as well.”
Thousands of military officers have been removed from the TSK in the aftermath of a failed coup attempt on July 15, 2016.
Most of the officers were expelled on the grounds that they had links to the faith-based Gülen movement, which is accused by the Turkish government of masterminding the failed coup attempt. The movement strongly denies any involvement in the putsch.
The next YAŞ meeting, where expulsions and promotions as well as the retirement of military officers are decided, will be held in August.


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About Rwanda Tea
Taste: Refreshing, crisp taste
3-5 minutes brewing time
100° C water temperature
4-5 heaped tsp./1 litre
Our Rwanda tea is a bright, flavourful tea with a bright coppery colour and a wonderful brisk taste. One of our popular tea's and Africa's best kept secrets.
"We can drink this all day, it's the wonderful Rwanda Tea"
PLEASE NOTE: This is a very fine leaf tea but of good quality, because it is a fine leaf tea does not mean its an inferior tea it is just how the tea is processed. This is not fannings as sometimes used by other producers for tea bags.
To help you get the best from our tea, click here to download our
FREE Tea Brewing Guide
Order today for same day dispatch.
TEA BAGS: unfortunately we can no longer get the grade of tea we require to produce tea bags so this tea is now only available as loose tea.

domain: food


Jay Z becomes first rapper nominated for the Songwriters Hall Of Fame
Jay Z has become the first rapper to be nominated for the Songwriters Hall of Fame.
Other nominees that could be inducted into the prestigious music organisation include Madonna, George Michael, Bryan Adams, Swedish pop hit-maker Max Martin and Kool & the Gang.
Members can vote for three non-performing songwriters and two performing songwriters until December 16.
Five songwriters, or songwriting groups, will be officially inducted at a gala in New York on June 15 next year.
Other performing nominees include Cat Stevens, Chicago, Gloria Estefan, Jeff Lynne and David Gates.
Songwriters are eligible for induction after writing hit songs for at least 20 years. Jay Z, who released his debut album, Reasonable Doubt, in 1996, has had multiple hits in the last two decades, from Big Pimpin' to Empire State of Mind.


Spencer Noon '13 Named Men's Soccer Co-Player of the Week
Spencer Noon was named the NESCAC
Men's Soccer Co-Player of the Week.
AMHERST, MA- The New England Small College Athletic Conference named Amherst College sophomore Spencer Noon (Farmington, CT) the Men’s Soccer Co-Player of the Week alongside Middlebury’s Jake Edwards this afternoon. Noon helped Amherst to wins over Connecticut College and Bridgewater State this weekend, lifting the Lord Jeffs to an unbeaten 4-0-2 record after six games.
Heading into the weekend, Noon sat atop the Amherst scoring ranks with a pair of goals and an assist through four games. Against Conn College on Saturday, Noon converted a penalty kick in the 68th minute to break a scoreless deadlock. The goal was a huge shift in momentum for Amherst, which seemed destined for overtime for the third straight conference game.
Shortly after the score, the Camels were reduced to ten men on the field following a second yellow card for Ryland Hormel. Noon needed just 43 seconds to seal the victory, making a near post run on a corner kick to redirect a header into the far side netting for his second tally of the day.
On Sunday, Amherst traveled to Bridgewater State for a non-conference tilt. The Amherst offense continued to roll, scoring five goals in the shutout win, with Noon putting home the third goal of the game. The win was Amherst’s third straight shutout victory, capping an eight day period that saw the Jeffs outscore their opposition by a 14-0 margin.
With his three goal weekend, Noon sits on five goals and an assist for 11 points in six games. The award is also Noon's second career Player of the Week honor after earning the title for the week ending September 14, 2009.
Noon and the Lord Jeffs will return to action on Saturday afternoon at NESCAC and Little Three archrival Williams College for a 12 p.m. game.


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Tag: Poly Network
Poly Network, the decentralized finance protocol, has asked the man behind the $610 million scam an advisory position and $500,000 whether he likes it or not.
Poly Network, the cryptocurrency exchange that was hacked earlier this week and lost $610 million (approximately Rs. 4,530 crores), revealed on Friday that it has awarded the hacker or hackers a $500,000 (about Rs. 3.7 crores) "bug bounty."
After claiming the big crypto theft was done ‘for fun,’ hackers have returned $342 million to Poly Network.
As hacker "Mr. White Hat" continues to restore stolen money to Poly Network, one of the largest cryptocurrency heists in history is gradually being undone.

domain: economics


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Starting on its second decade in the region, C3AFA Singapore is the biggest Japanese pop culture event in Asia! Check it out at the Suntec Singapore Convention & Exhibition Centre from 29th November to 1st December 2019!
One of the major series making their world debut at the event is the new multimedia franchise “Null & Peta”! Featuring the voice talents of Reina Ueda and Azumi Waki, So Japan is happy to be able to talk to both!
Is this your first time in Singapore? What do you most look forward to trying?
This will be my first time in Singapore, so I want to take a picture at the famous photo spot the Merlion!
“Null & Peta” is a new original project; can you tell us something interesting about the recording process that you were involved in?
We were only given five minutes so the speed was quite fast, and there are even times I had no idea which line I was supposed to say!
If you could be reborn in a robot body like “Peta”, what would it look like? What functions would you like it to have?
Peta is quite big, so I want to be a small robot, like a pet! And I’d be delighted if I had the ability to fly into the sky!
The “Null & Peta” trailer featured some fun retro games. What was your favourite childhood video game?
I’ve loved games since I was little, and I play a lot of Smash Bros. and Mario Kart! I beat my older brothers all the time!
C3AFASG 2019 is here very soon. What can your fans look forward to?
I would like to talk a lot about “Null & Peta”, so I hope you will all look forward to it!
Please give a message to your fans in Singapore and South East Asia.
It’s my first time in Singapore, so I am looking forward to meeting all the local fans very much!
We’re really excited to learn more about “Null & Peta”! Head on over to C3AFA Singapore 2019 to find out more! It’s not yet too late to purchase your tickets now via APACTix.com!
C3AFA Singapore 2019
29 November to 1 December
Suntec Singapore Convention & Exhibition Centre

domain: hobby


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Hi! We have a great promotion for those who want to buy two apartments from the following projects: Brilliant, Center, Flora, Lemon, Miami, Ekinova, Baraj Konutları, Eagle Terrace, Evim, Rio and Silver. If you buy two apartments you will get a discount of 3000 €!
We also have a special offer: the down payment is only 40% of the cost of apartments, and the remaining amount you can installments for 18 months!
Let's look at an example. Suppose you want to buy apartments in the RIO and Center projects. The price of an apartment in RIO is 92,000 € and in Center - 35,600 €. With a discount of 3,000 €, the total cost would be 89,000 €.
You can make a down payment of 35,600 € and the remaining 53,400 € in installments of 24 months. Thus, you can own two apartments for only 2,966 € per month!
If you prefer a different payment method, we offer a "balloon" option. With this option, you make a down payment of 35,600 € and install the remaining amount over 18 months. Thus, the monthly payment will be only 1,928 €!
Do not miss the opportunity to own two apartments at favorable conditions! Prices for the projects are 39 000 € and 53 000 €.

domain: finance


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Best Sewing Machine For Doll Making
Are you a seamstress, a quilter, dressmaker, crafter, or a sewing lover? Whichever title fits you best, you are an artist waiting to produce your most recent work of art with particular fabric, shades of thread and also special styles. You are one of the special individuals that create stunning art via the eye of the stitching needle. Best Sewing Machine For Doll Making
Sewing is enjoyable and also rewarding. From making easy points to creating masterful creative attached garments, it all begins with an idea, a pattern, color selections, designs and of course, a excellent sewing maker. Picking the right embroidery equipment will certainly save you time, power as well as maintain stress away.
If you are a novice, just starting to meddle the wonderful world of embroidery, or a seasoned expert, choosing the proper stitching machine is vital. Before you also consider a specific stitching maker, ask yourself what sort of drain you are or picture to be?
Then you must decide what functions are very important to you and your price variety. Understanding your needs ahead of time will assist you choose the most effective machine for you.
There are generally two kinds of sewing makers: Mechanical and Electronic. A mechanical machine will certainly require you to set and also manipulate the controls by hand, carrying out fundamental stitching jobs such as threading the needle, sew size, hemming, producing buttonholes together with standard maintenance.
An electronic embroidery machine will certainly automate most of the basic functions noted above, have an easily read LED screen, offer functions that are not offered on a mechanical equipment as well as reduce the problem of tiresome embroidery work.
A few attributes that are excellent are integrated lights to help with sewing darker items as well as for stitching during the night, a free arm for hemming, cuff stitching as well as sleeves, blind stitching, buttonhole capability, a string cutter, and a needle threader.
A variety of adaptable presser feet are invaluable to manage exactly how the material is being held and also moving as you are sewing to avoid puckering and unpleasant stretching of weaved textiles and various other fine materials. The ended up item will look a lot more specialist and also enticing.
I would rule out any type of equipment that does not come furnished with at the very least 6-10 built-in stitches, a zipper foot, free arm, drop-in bobbin, and also buttonhole maker that sews a buttonhole, preferably in one action eliminating the need for you to stop, turn the textile as well as readjust the dial. Best Sewing Machine For Doll Making
Whether mechanical or electronic, every one will have fundamental features and also sew functions that will certainly allow you to sew a selection of textiles using straight or zigzag stitches as well as sew lengths. Do not be satisfied with the basic capability however look beyond to the additional attributes and devices that makes each sewing maker one-of-a-kind to satisfy the demands you will place on it.
You need to likewise ask just how effective the motor is, how many stitches per minute, as well as just how it is constructed. The motor is the life of any kind of stitching machine. You do not wish to obtain caught without enough power to finish your task.
Every embroidery device will certainly have some plastic on the outside. Nevertheless, if you are going to sew a fair bit, you ought to take a look at the indoor framing and also style. Plastic interiors have a tendency to breakdown and flex while stitching, which can create the needle to relocate. On the other hand, a metal structure inside will offer years of sturdiness and specific sewing.
I would certainly be remiss if I did not touch on guarantees. While not typical, periodically a stitching maker will certainly damage or malfunction. It is very important to understand what the guarantee covers and for how long. It is best to be prepared must a circumstance emerge that needs interest beyond simple maintenance.
Allow us look at certain sewing makers and also that they are customized for.
Top Sewing Machines Reviewed
Let us consider particular stitching makers and also who they are customized for.
A nice novice design is appropriately called the “Confidence” by as it has all the attributes required to offer you all the self-confidence you require to develop amazing projects. The 7363 model consists of push-button stitch option, 30 built-in stitches, lock stitching for decorative embroidery, automated threader, tension control, and 1-step buttonhole maker. Best Sewing Machine For Doll Making
The framework is constructed of steel giving general toughness. This maker will grow with any kind of newbie, from easy tasks to a lot more complicated ones. offers a 25-year minimal service warranty as well as a variety of practical online video tutorials on using the device fundamentals in addition to suggestions and tricks to make stitching easier.
additionally offers the 1304 ” Begin” sewing machine that any person beginning to stitch ought to consider purchasing. This is a budget-friendly basic equipment created with a strong steel framework. Even though it only has 6 built-in stitches, other features make this machine rewarding so you can just start stitching promptly.
The preset stitch lengths as well as size take the uncertainty out of establishing the dials correctly. The zigzag and also straight stitching allows you to dabble in sewing appliques or adding a decorative scallop to the material. The complimentary arm allows you to hem garments or service cuffs and also collars.
With dual spool pins, you can stitch with a twin needle to double stitch in one pass. It has easy threading as well as bobbin winding along with an LED light. It is lightweight and can be taken anywhere.
For the advanced sewage system and also those looking to go up to the next degree of sewing with haute couture as your area of focus, after that the Singer 2010 Superb Computerized Embroidery Maker will stimulate your creativity.
The Singer Superb is a full-featured top quality version with extremely good stitch quality. It supplies 210 built-in stitches, adjustable speed, automated needle threading and also 10 presser feet for the freedom to let your creativity shine in your ended up job.
The 10 various presser feet range, including those used for zippers, hemming, and also buttonholes, along with a drop-in bobbin and also etched markings on the needle plate for a sewing overview. This device can stitch 750 stitches per min at maximum speed.
Singer likewise has a extremely great durable stitching maker if you are stitching several layers of material, denim, vinyl, canvas, pillows, drapes or creating costumes. The Singer durable 4452 sewing equipment is just one of the most effective on the market.
It has a powerful motor, size 16 long lasting needles as well as a non-stick foot that glides along the textile as opposed to binding and pulling it. It can sew any sort of product, normal fabric in addition to sturdy. Vocalist innovation supplies a great stitching application to give support as well as help anytime. Best Sewing Machine For Doll Making
If needlework is your wish plus embroidery, the Brother SE625 is specifically for needlework. This equipment has numerous superior attributes that include 80 integrated styles besides having a USB drive to integrate your own styles. The Brother site likewise supplies a huge selection of alternatives for this maker.
It has a color wise touch screen display to preview your job. Layout attributes consist of the ability to alter thread colors in a layout, use specialty letters, monogrammed therefore a lot more. There are 103 built-in stitches and 7 quick-change stress feet.
An intense workspace is featured with an automated needle threader and also free-motion stitching is paramount to embroidering, crafts, and also style. What is cool is the built-in tutorials that can be seen directly on the stitching equipment’s display screen. Making customized clothing and also presents is just the begin of the things you can do with this embroidery equipment.
Advance quilters as well as embroiderers will definitely fall in love with the Bernina 530 sewing device. The Bernina name alone is top quality and this maker will draw out creativity. Providing 148 stitches, the sophisticated sewage system can start any type of embroidery, quilting task while still having the capability of all fundamental common embroidery.
If you are a present drain looking for a first-rate sewing device upgrade, look no more than at Bernina devices.
The Bernina 530 has 11 different needle placements, suitable stitch control, optional stitch regulatory authority as well as an automated one-step buttonhole manufacturer that gives you, the developer, control over all your tasks. It has an easy-to-use control panel for fast access to the settings as well as patterns.
This equipment is a spectacular embroidery maker that can hold up against constant usage and also provides excellent features for an expert sewer. Identified with high quality, this deluxe equipment provides embroidery, quilting, and also typical stitching capabilities.
With a collection of 148 stitches, nine buttonhole choices, and 4 stitching alphabets, this device allows you to create your very own combinations of layouts by remembering your exact stitch specs as well as textiles in the onboard memory.
An additional specialty stitching equipment is a Serger. A serger is distinctively different from a normal sewing maker insofar as the serger stitches as well as reduces the product at the same time. You can consider it a certain style of stitching device that is frequently referred to as an overlock embroidery device. A serger utilizes 3 or 4 strings to develop a locked stitch at a quicker sewing rate. Babylock has been a leader in serger technology. It is perfect for finishing garment sides, rolled hemming and also Flatlock sewing. Clearly made for the sophisticated customer.
The Bro CS-5055 Job Path 50 Stitch Computerized Embroidery Device is appropriately called due to the fact that this sewing maker can take your sewing, fashion, as well as accessory layouts to the next level. With 87 Integrated stitches and 5 styles of buttonhole options, all will see your wonderfully influenced initial layouts. Best Sewing Machine For Doll Making
Regardless of your experience, there is a sewing machine that meets your needs as well as your spending plan. Singer, Bernina, Bro, and also Babylock are all popular quality makers of sewing equipments that have features that will take your creative thinking to the next degree.
All the sewing devices detailed can be located at sewingmachinesplus.com where the expert personnel can aid you with any concerns as well as obtain the best sewing equipment to you promptly. There is no demand to wait on your desire sewing machine. If you can imagine it, you can develop it, and we can place the best sewing device in your hands today.
Discover your creative thinking today.
- 1 Best Sewing Machine For Doll Making
- 2 Top Sewing Machines Reviewed
- 3 Specialty machines


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Nou Camp is closer to experiencing the greatest shock in this football era as the Argentine football legend, Lionel Messi is uncontrollably considering leaving the club before Summer transfer window shuts. If come to true, Messi would be the second major player to leave the club in a single season after the exit of Neymar Jnr who was sold to PSG for a world record fee.
Messi, whose current transfer expires next year, agreed with Barcelona in July to extend his contract with the club for another four years but it seems the Argentina legend is refusing to sign the deal. It was, however, learned that English football team, Manchester City is doing great to convince the player.
Though Messi could reconsider his deal with Barcelona for if signed, he would likely be the highest paid footballer on the planet but Manchester City can afford higher pay to convince the football wizard.
Sources from Barcelona has revealed that Manchester City is ready to sign Lionel Messi with his £275m release clause. The source further disclosed that Lionel Messi is "seriously considering leaving.

domain: news


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There will be no cancellations of major events and rallies because of the current situation regarding the coronavirus, which has also arrived in Serbia, said Serbian Prime Minister Ana Brnabic on Sunday.
„As Prime Minister, I follow the recommendations of expert bodies, the line ministry, and experts. There is no need to cancel such events at this time. If necessary, we will respond to it immediately,“ Brnabic said.
The Prime Minister reiterated that there is no room for panic about the emergence of the coronavirus in Serbia, that expert services are working daily, and that the Government would react if needed.
So far, only one case of coronavirus infection has been registered in Serbia, and 91 people have been tested.


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domain: health


text:
University Of California Berkeley Cal Medallion Engraved Encore Diploma Frame.
247681 – Gold Engraved Medallion (Encore)
· Features a gold engraved medallion of the University of California at Berkeley seal set into a 23K bezel. It is recessed into navy museum-quality matting in our Encore moulding with the school name gold embossed below.
· The Encore moulding is crafted of solid hardwood with a striking high-gloss cherry finish and black accents.
· This frame fits a Bachelor's, Master's and PhD degree
This frame fits a Bachelor's, Master's and PhD degree. This product comes with UPS and Fed-X certified packaging to ensure safe arrival.

domain: design


text:
It all started last may, when I decided to try and sew myself a new handbag for spring. Using a pattern from this book, I made the bag above. It was so much fun, that I decided to make another on with a different pattern, which became a gift.Then I was inspired to try my hand at felting a bag for the fall, and created this.
My mother really liked the felted look and asked me to make one for her for Christmas. I was thrilled. Here's what I came up with for my mom.
I also made 8 of these tote bags for Christmas gifts.
I have no good reason to make another bag, but today I bought some more wool yarn (on sale-yay!) for yet another bag. I saw a design that I just HAVE to try out. I love the idea of creating something pretty, and so useful too! I anticipate that 2008 is going to be "the year of the bag" for me. ;)

domain: artistic


On Tuesday, December 12, 2017, President Trump signed into law: the National Defense Authorization Act. This bill reinstates the Federal Aviation Administration (FAA) drone registration requirement for all drones weighing between 0.55 and 55 pounds.
Drone registration provides a way to quickly identify a small unmanned aircraft systems (sUAS) in the event of an incident or accident involving the sUAS. Registration also provides a way for the FAA to communicate directly with drone owners to provide education on safety requirements during the pre-flight registration process.
“We welcome the reinstatement of registration rules for all small unmanned aircraft,” the FAA said. “Ownership identification helps promote safe and responsible drone operation and is a key component to full integration.”
This reinstatement goes back into effect immediately. The FAA drone registration website states that those who do not comply will be subject to civil and criminal penalties. So everyone with a hobbyist or consumer drone weighing between .55 and 55 pounds will need to get their drones registered asap. You can register by visiting the FAA drone registration website (https://registermyuas.faa.gov/).


Roberts court takes aim at gun control
ON THE U.S. SUPREME COURT DECISIONS
Published 4:00 am, Tuesday, June 29, 2010
As Elena Kagan's confirmation hearings began Monday, the Roberts court offered a reminder of the criticality of each vote by the highest court in the land. In a 5-4 ruling, the high court all but declared open season on state and local gun laws. It asserted in its clearest terms yet that the Second Amendment gives Americans a fundamental right to bear arms. The majority opinion also cited the 14th Amendment, which asserts, "no state shall make or enforce any law which shall abridge the privileges or immunities of citizens of the United States."
The immediate effect of the ruling is to all but doom severe restrictions on handguns in Chicago and its suburb of Oak Park. But the ruling almost certainly invites challenges to state and local laws everywhere that were designed to limit the types and volume of lethal weapons on our streets.


text:
FREE | Wednesday, November 11, 12-2pm
Registration is required to access this event.
Description: J.D. Shields is an award-winning director and writer of film, television and interactive media. She will share her experiences as a writer and director for interactive and gaming media.
The official VPA events calendar www.hccs.edu/hccevents |
All Fall 2020 VPA events and classes are online only.
• Venues and Galleries are ACCESSIBLE and OPEN to the public during CAMPUS HOURS except where otherwise noted. • ALL events are FREE. • PARK in student lots, FREE. • Houston Community College SUPPORTS ACADEMIC FREEDOM and First Amendment rights. • Some artwork may be objectionable to some viewers and some productions may contain sensitive language and/or subject matter.
This event is presented by the VISUAL & PERFORMING ARTS Center of Excellence. DEAN, Colleen Reilly, PhD. • VISUAL ARTS DIVISION (Studio Art & Art History) CHAIR, Katherine Rhodes Fields, MFA, MA TESL • PERFORMING ARTS DIVISION (Dance, Drama, Music) CHAIR, Susan Hines, MM • MEDIA ARTS DIVISION (Filmmaking, Audio Recording, Music Business) CHAIR, Michael Cohn, MA


Dubai: Temperatures have reached 50 degrees Celsius in the UAE with humidity levels as high as 85 per cent.
So why is it raining in some parts of the country in August?
According to the National Centre of Meteorology and Seismology (NCMS), it’s the monsoon season in India. Bearing that in mind, the convective clouds are blowing in from the south eastern part of India, and what’s left of the rain ultimately ends up in the UAE, such as in the areas of Masafi, Al Madam and Fili.
— UAE WEATHER (@NCMS_media) August 2, 2017
So while it will continue raining in some parts of the eastern and southern region, the inland areas and cities of Abu Dhabi, Dubai and Sharjah will remain hot and dry without a raindrop in sight.— UAE WEATHER (@NCMS_media) August 2, 2017
The NCMS is warning residents not to stay outdoors, especially from 2-4pm, as the level of humidity will reach 85 per cent until Friday.— UAE WEATHER (@NCMS_media) August 1, 2017
Convective clouds are expected to continue forming in some hot to very hot in general, hazy and partly cloudy at times. The amount of clouds will also increase over some eastern and southern areas by the afternoon, which will bring in more rain.
Temperatures are expected to reach 39C in mountain areas, and will peak at 49C and 46C in internal and coastal areas respectively.