You spend countless hours, not to mention considerable money, to secure your SAP and Oracle ERP data. One day, you discover that cybercriminals have exposed a vulnerability using an application misconfiguration. This has become increasingly common as criminals seek methods to covertly infiltrate applications to gain access to thousands of employee records.
This situation happened to Microsoft in December 2019 and didn’t generate the kind of headlines usually associated with data breaches. This was simply a human error. But these kinds of human errors and misconfigurations are one way that hackers can gain a foothold into your SAP or PeopleSoft ERP system. Now the question is, how are you going to protect your data after an attacker side-stepped your perimeter defenses?
Misconfiguration is the Fastest Growing Security Risk
According to the 2020 Verizon Data Breach Investigations Report, misconfiguration errors (failing to implement all security controls) are up 4.9% from last year’s report and are the fastest-growing risk to web applications. It’s easy to apply this kind of risk to legacy ERP systems because SAP and PeopleSoft environments often consist of millions of lines of custom code and custom-built components communicating with each other and to external systems through various APIs and interfaces bolted together over time.
On top of that, you’re dealing with an abundance of changes to roles, configurations, access controls, and compliance protocols to accommodate new business processes and evolving data privacy policies. If companies are not analyzing and monitoring the underlying security implications of all these changes and movement, they’re bound to face a similar situation as Microsoft with a backdoor left unlocked for any hacker to stroll through.
Finally, don’t forget that many organizations simply do not stay current with system updates and security patches. According to the Data Breach Investigations Report, only half of the vulnerabilities are patched within three months after discovery, leaving companies exposed to attacks against known exploits.
The Multi-Layered ERP Data Security Approach
The growing complexity of SAP and PeopleSoft environments make securing ERP data an enormous challenge. To prevent inadvertent exposures from misconfiguration, Greg Wendt, executive director of Appsian, suggests that companies “must adopt a multi-layered security approach with dynamic security tools that can monitor user access in real-time, providing transparency over what data is accessed and by whom.”
This multi-layered approach includes masking sensitive data, verifying identity via multi-factor authentication (MFA), and enhanced logging and analytics. Appsian adds layers of security WITHIN your ERP system to help ensure your data is still protected when a hacker strolls past your perimeter defenses, thanks to a misconfiguration.
Dynamic Data Masking provides contextual masking policies that adapt to the context of access. That means when a hacker attempts to access sensitive data fields but doesn’t match key attributes such as user ID, privilege, device, location, or IP address, they will encounter full, partial, click-to-view masking or complete redaction of the data field.
Adaptive MFA ensures that contextual attributes (ex. device, network, location) are the determining factor for deploying MFA challenges. For example, customers can require an MFA challenge when a user account is accessing the system from a remote IP address or after business hours.
Enhanced Logging and Analytics with Appsian360 allow you to monitor your networks for suspicious activity and provide detailed insights regarding how, when, and by whom transactions and data fields are being accessed. This visibility is particularly important for identifying users with high-privilege access who are accessing pages they shouldn’t be. The enhanced logging can trace all the pages a user accessed during a session, helping to identify a potential intrusion. This kind of real-time data access and usage visibility was previously unavailable to SAP and Oracle ERP customers.
Eyes and Ears on the Entire ERP Data Ecosystem at All Times
“The enterprise must learn to have eyes and ears on their entire data ecosystem at all times,” said Wendt. Microsoft’s recent data breach due to misconfiguration highlights the importance of a security strategy that continuously looks for misconfigurations and compliance violations. Next, they should establish a multi-layered security approach to prevent unauthorized data access, along with enabling organizations with the ability to identify access trends that may be indicative of incorrect access controls.
Misconfigurations are, unfortunately, a common error and should be treated with the same sense of urgency and level of effort by security professionals as their network perimeter. After all, not all attacks are external.
Contact us today to learn how the Appsian Security Platform and Appsian360 can help you establish a multi-layered security solution.
The news is flooded with stories about cybercriminals successfully engaging in phishing and social engineering aimed at exploiting people’s COVID-19 fears, all in order to steal user credentials to business applications and VPNs. From fake delivery notifications to World Health Organization (WHO) impersonations, malicious actors are preying on people’s emotions during this pandemic.
The credentials used for authentication are ultimately an organization’s network perimeter. This puts organizations in a difficult position — they can limit employee’s access to these systems and risk negative impacts on productivity and business continuity, or they could bury their head in the sand and hope nothing bad happens. Many are choosing the latter, and the implications are being felt worldwide.
Why There is a Correlation Between a Stressful Environment and Cyber Attack Volume
Social engineering fundamentally relies on taking advantage of strong emotions to trick people into taking actions that can cause them harm. This crisis has emotions running high, and many employees are stuck in a state of fight or flight.
Research shows that stress impairs the brain’s ability to make decisions. That’s why, when people are under stress, they often take more risks and engage in activities that could cause them harm. In other words, employees are not forgetting their phishing trainings, their brains are functionally incapable of making good decisions.
Cybercriminals rely on emotional responses — whether it’s clicking on links, downloading documents, or opening attachments — emotionally charged content (e.g., fake layoff announcement email with a malware attachment) is more likely to result in a successful attack
The problem isn’t the people, it’s the cybercriminals and the tactics they use.
The Principle of Least Privilege
Often, companies view data protection solely from the compliance and financial risk perspective. Unfortunately, this doesn’t go nearly far enough. It is recommended that companies consider limiting user access to resources based on the principle of least privilege, or the absolute minimum access necessary to complete a job function. Least privilege is a governance strategy that has never been more relevant than today — especially as organizations rely on remote workforces. Fundamentally, when users have more access than necessary, they may accidentally (or intentionally) violate compliance requirements designed to protect the organization.
Today, access governance is largely dictated by predetermined roles and permissions usually classified into groups (administrator, power user, etc.) This classification of permissions is tied to authentication processes like username/password security models that are heavily targeted by cybercriminals through phishing and social engineering. Further, if a phishing attack compromises a user’s credentials, then the cybercriminal may access or acquire as much sensitive data as their victim’s role will allow. This is precisely were least privilege should kick in.
The rise of phishing attacks that target coronavirus fears not only places organizational data at risk, but it also places employees at risk — especially those with high privileges. Many employees use the same credentials for multiple applications, such as social media networks and shared cloud drives. If one set of credentials is compromised, multiple systems are now at risk.
Limiting access to data according to the principle of least privilege provides organizations with the tools necessary to prevent catastrophic data breaches. A good question to ask yourself is, what data should my administrators and power users have access to? Do they need easy access to executive payroll data? Do they need easy access to other employee social security numbers? What do they really need easy access to in order to do their job?
The truth is, they will likely need access to some sensitive data, so how do you protect data that still falls under the principal of least privilege?
“Zero trust” often sounds harsh — trust no one, assume a threat at all access points, and never grant access by default (e.g., a predetermined role and privilege.) At first glance, this mentality appears to go against corporate values like collaboration and integrity, but, in reality, it fosters them.
Moving toward an IT culture based on zero trust means that an organization can identify all devices, users, applications, and data across its ecosystem. Then, the organization can establish the appropriate controls that limit access where appropriate.
Fundamentally, a zero trust model encourages collaboration and integrity while also supporting employees who mean well but could be making risky decisions while under stress — coronavirus related or otherwise. By setting zero trust identity and access controls, organizations ensure constant alignment between who an employee is and what they have access to, thus, mitigating risk.
Part of establishing an effective zero trust model involves finding solutions that allow organizations to apply contextual attributes when granting access. Attribute-based controls adapt to different contexts and ultimately drive how and when users can access information. For example, an attribute might be geolocation or time of day. Adaptive multi-factor authentication (MFA) takes these attributes and requires additional authentication as users move across systems or within applications. For example, to log into an ERP system, passing a standard authentication challenge is required. Then, to update direct deposit or access payroll information, an adaptive MFA challenge should be deployed. Zero trust means that just because they passed through the front door of the application, they can’t execute the most sensitive transactions.
As employees work remotely, organizations may want to incorporate adaptive MFA so employees in finance or human resources can securely authenticate to their ERP systems. Adaptive MFA will detect anomalous locations or times for activity, trigger an additional authentication process, and prevent malicious actor access.
Ultimately, zero trust and adaptive MFA protect the organization, the person whose information was almost leaked, and the employee whose credentials were stolen. The organization can be alerted to the cyber criminal’s attempt to gain entry to its networks, the person whose data was almost leaked retains privacy, and the employee whose credentials were phished is protected from the negative impact of their privilege being hijacked.
Remote Access Means Phishing and Phishing Requires Additional Strategies
Organizations have tried to protect themselves from phishing attacks for years. What they have not done is protect themselves during a time of social, emotional, and physical upheaval. But, the current upward trend in phishing attacks should come as no surprise to organizations. Cybercriminals never rest — they take advantage of any weaknesses in an IT ecosystem, both digital and human.
Maintaining strong identity and access governance strategies ensures that both data and end-users can be protected during these strange and unusual times.
This article was originally published by Mission Critical Magazine.
On April 19, 2020, Oracle announced on its PeopleSoft Support blog that the company is extending support for the ERP application through 2031. As stated on the blog, Oracle remains “committed to a rolling ten years of support for PeopleSoft. We will review and plan to extend support again next year, and the year after that, so that you have a decade of committed support and can plan your enterprise software investments accordingly.”
This news should give PeopleSoft customers a sense of certainty that investing in the long-term success of their PeopleSoft applications is mission-critical. Thanks to COVID-19, organizations may be concerned about their short-term financial stability. Add in the newfound uncertainly of continuing large-scale IT projects in this climate (like a cloud ERP migration) – organizations have now found themselves looking for ways to reap maximum benefits with the lowest degree of overhead and project completion time.
Three “Home Improvement” PeopleSoft Data Security Projects
With large-scale projects on hold, it’s a good time to invest in smaller-scale projects that focus on what is truly mission-critical today (and for the near future) – PeopleSoft data security. You’re already working hard to secure data while users are accessing remotely and while bandaids may be in place right now, organizations must consider strategies that scale long-term.
Here are three smaller “home improvement” projects that strengthen your PeopleSoft data security posture:
Integrate your SAML Identity Provider (IdP) for Single Sign-On (SSO)
When you count the hours spent managing passwords (80% of help desk calls) or tackling SSO projects using customizations and home-grown solutions, you find that removing the complexity of PeopleSoft password management is an ROI positive project. Add in the lost productivity of users not being able to access business transactions (because they’re waiting for their password to be reset), then the ROI increases. The bottom line, a SAML-configured Single Sign-On for PeopleSoft will make everybody happy. A SAML SSO provides the combination of security and productivity that organizations are striving for. And, given the alarming uptick in phishing attacks – user credentials have become an obvious liability.
Strengthen IAM with Adaptive Multi-Factor Authentication (MFA)
When you’re buying new appliances for a remodeling project, you buy a washer and dryer in pairs. Yes, you can wash and dry your clothes using one or the other, but using both is a better option. Same with applying an adaptive multi-factor authentication (MFA) with your SSO as an effective method for verifying identity. Adaptive MFA ensures that contextual attributes (ex. device, network, location) are the determining factor for deploying MFA challenges. The context of access varies in mobile and work-from-home environments, and your level of control should do the same. This is essential if your users are accessing remotely, as managing authentication (especially for high privilege users) can be challenging.
It is also recommended to expand the use of MFA and apply step-up challenges on transactions that may be considered ‘highly sensitive.’
Real-Time Visibility for User Activity Monitoring and Transaction Logging
Just like a rug can tie a room together, real-time visibility via user activity monitoring and transaction logging can be the perfect complement to your PeopleSoft data security fixer upper. There are a lot of sensitive transactions being executed outside of the office these days, and monitoring user activity gives you a better sense of how your data is being accessed and used.
Invest in Today and Plan for Tomorrow
Now is a good time to take Oracle’s lead in their extension of PeopleSoft support – and alleviate a lot of the complexity around PeopleSoft data security, identity, and access management. Securing remote access with SSO and adaptive MFA today provides significant PeopleSoft ROI – along with applying a strong data security framework that can scale with a myriad of workforce and landscape changes.
Best yet, you can complete these projects in only two to four weeks, and we guarantee you won’t be cleaning up any sawdust when you’re done.
Request a demonstration of the Appsian Security Platform today.
With remote workplaces being put to the test, organizations are looking to quickly scale their security practices. Unfortunately, many are learning the hard way. They find themselves at the intersection of using conventional security technology like a virtual private network (VPN) to secure data residing in traditional, on-premise ERP applications like PeopleSoft and SAP ECC. This can be a toxic combination that may leave you feeling secure, but it should be noted that your data remains at risk.
A VPN is Not Data Security
Plain and simple – a VPN is a connection point. While it may shrink your threat surface, there are still many risk factors to consider. For instance: where is a user coming from? What data are they trying to access? What device are they using? Is that device actually being used by the right person? What PeopleSoft data are they trying to extract onto their personal device? And so on, and so one…
Once a VPN authenticates a user, a myriad of risk factors remain. This is where a VPN ends and data security should begin. However, most organizations are simply not prepared to mitigate the risks that come once a user has passed a VPN. Here are a few examples:
Federating High Privilege Users
High privilege users should face the most scrutiny. Ideally, a high privilege user should authenticate through Active Directory or whatever identity provider an organization is using. They should then receive federated privileges to PeopleSoft based on the contextual attributes of their access (ex. are they accessing from a foreign country?) Federating high privilege access is a fundamental way to ensure a user is provided with the appropriate level of privilege. However, a VPN cannot do this. In fact, authenticating to PeopleSoft using a SAML identity provider (like Active Directory) can be challenging unto itself (see this blog for more info.)
If the point of a VPN is securing remote access, then why not consider the contextual attributes that come with said access? After all, the remoteness is what is considered the risk. In this scenario, a VPN is merely acting as a thin authentication layer, on top of PeopleSoft’s typical username and password model. What if a user opts to make their VPN password the same as their PeopleSoft password? This is what hackers anticipate and sadly, they are usually correct.
Malicious Insiders Tend to be High Privilege Users
This is a touchy subject but should be acknowledged. While no one wants to assume the worst in their employees, the fact remains that the more access you have, the more damage you can do. Given the right motivation – bad things can happen. This is the most compelling case for data security because the highest stakes surround high privilege users. A/P, A/R, Finance, Supply Chain, Payroll – all these functions deal with money. Having the ability to lock down and limit access to data and transactions will have a tremendous impact on an organization’s ability to mitigate financial losses from fraud, theft, and espionage. And because of COVID-19, all of these functions are now being executed remotely. The potential for damage is exponentially greater than before.
Ask yourself – should payroll queries be run and exported onto a personal device? Should wires be sent outside of normal business hours? Should a vendor be created when access is coming from a foreign country? I believe the answer you’re looking for is… NOOOOOOO!!!
Integrating dynamic, risk aware controls on sensitive financial transactions (and data fields) mitigates much of this risk. In addition, transaction logging and analytics prove to be extremely beneficial, as many organizations would prefer not to hamstring their employees with restrictions. However, they would prefer to gain better visibility in case an anomaly is detected.
A VPN Can Be Costly, Unscalable, and Leave You in The Lurch
Like any addition to your architecture, downtime can occur. VPN vendors can experience enterprise-wide outages – causing major disruption. In addition, with organizations moving toward a 100% remote access, VPNs can be prone to kicking people off after a period of time. Adjusting to remote work environments is frustrating enough, but if access is limited or hindered, and you don’t have the benefit of a readily available help desk – your users will become agitated. With so many senior leaders focused on business continuity, having additional hoops for your employees to jump through is counter to productivity.
And then there is the cost factor – which will certainly balloon with the increased number of users. We understand that costs will vary, but the ROI of 100% of your employees requiring a VPN to log into PeopleSoft is not positive. And as we established above, if the point of a VPN is increasing data security/maintaining integrity of financial transactions – then the ROI is even further from positive.
How Appsian Provides ERP Data Security for PeopleSoft and SAP Applications
Appsian believes user authentication is important, but it’s only one part of an ERP data security posture. This is why we developed the Appsian Security Platform for PeopleSoft. Enhancing an organizations ability to authenticate users is most effective when its: integrated with your existing identity management strategy and risk aware. This is where Appsian provides far greater value than a VPN. We enable seamless, secure access to PeopleSoft (specifically) via Single Sign-On (integrated with a SAML IdP), along with adaptive Multi-Factor Authentication. These solutions combine to provide a much better user experience and a vastly superior value if protecting PeopleSoft from bad actors is the primary intention of your VPN.
Lastly, visibility is key. With sensitive transactions being executed outside of the office having a better sense of how your data is being accessed and used is critically important. Using transaction logging and real-time analytics, Appsian provides PeopleSoft customers with unparalleled levels of visibility. Thus, allowing you to keep a watchful eye on your data at all times.
When approaching how you can enable secure, remote access – its best to identify what are the key objectives and invest in the technology that best suits those needs. Are you concerned that the data inside your ERP applications could be breached or exfiltrated? Are you concerned that financial transactions could be corrupted? If the answer is yes, then data security – and not solely a VPN are the answer.
At the end of the day, COVID-19 has forced organizations into unprecedented challenges. With an unstable market and unpredictable year(s) ahead, it’s important to focus security efforts on internal data and processes – as these being corrupted will result in losses that can make recovery significantly harder.


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Platform(s): PC (Reviewed), PlayStation 4,
Gene(s): Action, Casual, Indie, Massively Multiplayer, Sports
Publisher: Devolver Digital
Fall Guys is the ultimate party game that we needed in 2020. This is a last bean standing game in a battle royale mode. It’s the virtual equivalent of Takeshi’s Castle, Ninja Warrior, and Wipeout. The game is this wonderfully bright and fruit-filled levels of chaos where 60 beans start and get whittled down the winner bean through multiple puzzles (24 levels). It takes the approach of being focussed on the mechanics of a few puzzles and putting players against each other in a frenetic race to the finish.
The game hits the sweet spot of being amazingly fun, a mix of chaos, frustrating, and having a huge sense of accomplishment and relief if you win. The game isn’t perfect but everyone starts on the same level, a mixture of luck and good gameplay will get you through the challenges. The random events like a banana or an orange squishing you as you negotiate a travelator will happen, but you need to get up and persist. All the spills, the falls, and, squishing are hugely entertaining even if you are on the receiving end. This game hugely emphasises fun and playfulness but does have a competitive edge, these all combined are a superb treat. It nails the fun factor so well.
I have to say this such a breath of fresh air, a party game that is amazingly simple but super addictive and so fun. It requires very little to pick up and play. It’s fun if even if you don’t know what you are doing at the start. You will still enjoy the straight forward game mechanics in the multiple puzzles.
This is an online gaming experience that could do with offline local party mode but this doesn’t detract from how awesome and fun the game is. The game will leave you a little frustrated at the start as you constantly get bundled over as you try to qualify from your heat, but as you progress through the levels you have a huge pay-off which makes the game such fun.

domain: game


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Remakes, re-imaginings, reboots, re-inventions, other re-… Hollywood seems to like re-cycling of ideas and have been in serious innovation drought for years. I know, remakes of classic (and not so classic) movies are nothing new, neither are sequels – but there are a few things they could do in order to inject some imagination into their fantasy films.
This essay was originally written for Planet Origo and published there in February 2009. The essay does not pertain directly to specific Scandinavian films, but suggest Hollywood take more notice of themes that are native to Nordic cinema.
Fortunately, the sci-fi and fantasy film genres have been spared the biggest remake waves. Horror has been hit much worse, with classics such as Texas Chainsaw Massacre, The Hitcher, Friday the 13th, and Helloween having been remade, among many others. There was even talk about The Evil Dead getting a remake, and it actually has an IMDb entry labelled “announced”. Is nothing holy to Hollyweird??!?!
Fantasy films are in a slightly different position. While horror movies have been huge since the 1970s and established long before that, fantasy and science fiction films were mocked and looked down upon longer, and it wasn’t until the mid or late 1990s that fantasy in litterature became the foundation for a wave of movies. Granted, fantasy movies have been around for a long time but in fact the growth in the 90s in numbers of young people who read fantasy stories paved the way for movie adaptions of popular novels. With The Lord of The Rings and Harry Potter it was proven true that popular fantasy books could translate well to box office success.
In other words, the makers of fantastical cinema have a vast library of already proven stories to choose from, a library that is not yet empty. They don’t need to recycle. However, it is just a matter of time before remakes or sequels to popular 1980s movies start to appear. They are already preparing remakes of He-Man and V, in the wake of the reboots of the comic franchises Superman and Batman.
So, Hollyweird, let me give you some advice. A free tip, an original and new idea you have not explored much before. You can pay me a hefty royalty if you want. Here it is: Nordic mythology.
I am not talking about Viking movies. Vikings have acted in front of the camera since at least the 1950s, usually with a large dose of, shall we say, artistic freedom. Myths and misconceptions and adaptions of Viking history and / or facts are, if not a staple, at least well known among movie fans. No, I am talking about Nordic mythology; the gods, beliefs, myths and legends of the Vikings. You know, Thor, Loki, the giant jotnar creatures, Odin, the eight-legged horse Sleipnir, etc. Also, a whole range of worlds and universes inhabited by magic, spirits and supernatural creatures. There’s much to dig into!
I am not suggesting a movie about Norse mythology, but perhaps Hollyweird could look to Scandinavia for some juicy inspiration for original stories. It has been done before, in all fairness, although not as a rule when making fantasy films inspired by the past, or even when making “plain” Viking epics. Tolkien took alot of inspiration from ancient Scandinavian culture when writing both The Silmarillion and The Rings trilogy, in fact so much that the mythology crept into popular culture and has become clichés. The John McTiernan-directed The 13th Warrior (1999) is borderline historical fantasy as it involves the fictional and non-historical cave cannibals attacking a Viking village, and Outlander (2009) sees Vikings and space aliens clashing, a rare thing even in fantasy movies. None of these two movies draw much from actual Viking mythology though. Beowulf (2007) is probably the best cinematic adaption of old Scandinavian legends (though it’s an English poem), even though the character Beowulf supposedly lived 4-500 years before the Viking age.
However, apart from the Thor comic books from Marvel Comics, Nordic mythology is not exploited enough in popular entertainment. In stead, Greek legends, Arabian folk tales and Asian history forms much of the basis for fantasy epics, with the occasional dip into Britain’s Merlin or American Indian folkore. I guess there is alot to explore in sub-Sahara African legends too (Tarzan aside – it wasn’t really an African legend) but being a Norwegian myself, I’d like to see more Nordic mythology on the big screen.
So there you have it, Hollyweird. Why don’t you google or wiki terms such as Jotun, Yggdrasil, Valhalla, Ragnarok, the vættir, Freya. You don’t even have to pay authors any rights, because all Nordic mythology is in the public domain, one could say. There goes my royalty cheque!
I am of course available as historical consultant, and won’t charge you more than you can afford.
Addendum: After this essay was written, Marvel studios has filmed Thor under the direction of Kenneth Branagh. Scheduled to open on May 6th, 2011, the film is based on the Marvel comic book rather than actual Norse mythology, and is as such more a comic book movie than a Norse mythology movie. Still, we applaud the idea!

domain: artistic


UNECE is an implementing partner in the United Nations Development Account project “Global Initiative towards post-Covid-19 resurgence of the MSME sector”, conceived to strengthen the capacity and resilience of micro-, small and medium enterprises (MSME) in developing countries and economies in transition to mitigate the economic and social impact of the COVID-19 crisis.
One of the UNECE activities is to explore best practices and develop guidelines for MSME in delivering energy-efficient products and services and in providing renewable energy equipment in response to the crisis. One of the outputs of this work is a report "Guidelines and best practices for MSME in delivering energy-efficient products and in providing renewable energy equipment" (August 2020) that is available in English and in Russian. This report was used to develop a related online training course whereby two workshops were held (in English,14 September 2020, and in Russian,1 October 2020). The report was discussed by the Group of Experts on Energy Efficiency at its seventh session (Geneva and online, 22 and 25 September 2020). The work under the project also provided the basis for a publication entitled "Guidelines and Best Practices for Micro-, Small and Medium Enterprises in Delivering Energy-Efficient Products and in Providing Renewable Energy Equipment", which is available for download.
Intensive Learning Session at the EE Global 2018 on Overcoming Barriers to Investing in Energy Efficiency (21 May 2018, Copenhagen)
The session organized jointly by UNECE, Copenhagen Centre on Energy Efficiency, and Institute for Energy Efficiency in Production/EEP looked in more detail into investment decisions in the industry sector, in particular what helps viable projects to be identified and implemented and what stimulates companies to make decisions to finance and implement energy efficiency measures and projects.
Peer learning round table Improving the efficiency of the energy system (1 March 2018, Geneva)
This round table is held in the framework of the Regional Forum on Sustainable Development (1-2 March 2018).
It facilitated peer learning and practical exchange of experiences and best practices for implementing the Sustainable Development Goal 7 (SDG7). The Regional Forum on Sustainable Development (RFSD) follows up on and reviews the implementation of the 2030 Agenda and its Sustainable Development Goals (SDGs) in the UNECE region.
SDG 7 Sustainable Energy
- What are countries doing to overcome barriers to improving energy efficiency?
- What approaches have been effective in accelerating investments in energy efficiency?
- What is being done to improve energy efficiency in industry?
- What steps are countries taking to improve energy performance of buildings?
|Ukraine: Improving Energy Efficiency – Launch of the State Program on Energy Efficiency
|Establishment and operation of the Budgetary Fund for Energy Efficiency
|The former Yugoslav Republic of Macedonia
|Raising awareness for energy consumption through a marketing campaign “Energy Mathematics”
|Applying industrial waste heat to supply new city district in Hamburg


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Material & Care
- sizes 6-16
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- 1970's Style
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- model is 5'9/12"
- non stretch fabric is designed to be worn loose with room to move
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Shes by Habbot
- all measurements in cm on a flat garment
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Leonard St garments are designed to make you feel good in them and about who made them.
Read more about our sustainable and ethical production.

domain: design


text:
|Year : 2014 | Volume
| Issue : 2 | Page : 35-40
Bioadhesive chlorhexidine gel for reduction of alveolar osteitis incidence: Systematic review and meta-analysis of randomized controlled trials
Mahmood Reza Kalantar Motamedi1, Saber Khazaei2
1 Dental Students Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
2 Research Department, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
|Date of Web Publication||2-Jun-2014|
Research Department, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah
Source of Support: None, Conflict of Interest: None
Introduction: Alveolar osteitis (AO) creates severe and self-limiting pain, which needs to be treated with several postoperative visits, leading to increases in patient's morbidity and costs. Hence, the most basic and best treatment could be prevention. The aim of this study was to investigate the efficacy of bioadhesive chlorhexidine (CHX) gel in reducing AO occurrence with published studies. Materials and Methods: Medline/PubMed, Scopus, EBSCO, Ovid and Cochrane central registry for control trial were searched up to 28 February 2014 using "alveolar osteitis" and "chlorhexidine" as key words for systematic review and meta-analysis. Inclusion criteria were prospective and randomized controlled trials (RCTs) published on this topic. From the chosen studies, the eligible articles were reviewed. Data were analyzed using Review Manager 5.2 software. Results: Out of 43 studies, seven eligible trials with 593 participants were selected. Bioadhesive 0.2% CHX gel prevented approximately 72% of AO (Odd ratio (OR) = 0.28, 95% confidence Interval (CI): 0.18-0.44; P < 0.001). Conclusion: Bioadhesive 0.2% CHX gel may be effective as a post-medication to reduce incidence of AO.
Keywords: Alveolar osteitis, chlorhexidine, systematic review
|How to cite this article:|
Motamedi MK, Khazaei S. Bioadhesive chlorhexidine gel for reduction of alveolar osteitis incidence: Systematic review and meta-analysis of randomized controlled trials. Dent Hypotheses 2014;5:35-40
|How to cite this URL:|
Motamedi MK, Khazaei S. Bioadhesive chlorhexidine gel for reduction of alveolar osteitis incidence: Systematic review and meta-analysis of randomized controlled trials. Dent Hypotheses [serial online] 2014 [cited 2023 May 31];5:35-40. Available from: http://www.dentalhypotheses.com/text.asp?2014/5/2/35/133420
| Introduction|| |
Alveolar osteitis (AO) known as dry socket and is identified as a severe pain in or around the site of an extracted tooth, intensifying any time between the first and third postoperative days, accompanying with partial or total blood clot loss in the alveolar socket.  AO is a common complication following surgical removal of impacted mandibular third molar (up to 30%) and extraction of any other teeth (up to 70%). ,,,, This is a multifactorial condition and the exact causative agent is not clear; however, fibrinolytic cascade and bacterial factors have been reported as the main ones. ,
AO leads to severe pain, which needs several postoperative visits to be treated, leading to increase in patient's morbidity and costs. Owing to the proposed microbial origin, prevention of AO has focused on systemic and topical antimicrobial therapies.
Chlorhexidine (CHX), povidone iodine, 9-aminoacridine, metronidazole, tetracycline, and clindamycin in both systemic and localized regimens have been utilized as preventatives with varying degrees of success. ,, Of them, the most extensively tested therapy was CHX due to its broad spectrum of activity versus oral aerobes and anaerobes, general tolerability, and absence of resistance development. , On the contrary, a number of authors found it ineffective. ,,
The introduction of bioadhesive CHX gel turned lights on a new line of investigation. ,, The gel could be more effective than mouthwash because when positioned intra-alveolar provides more bioavailability and prolonged release of the active substance and also can act directly on the alveolus. ,,
Several studies regarding local interventions, especially, the use of CHX for prevention of AO have been performed, but no one has focused particularly on bioadhesive CHX gel. ,,, On the other hand, it has been reported that short-term use of CHX mouthwash can cause some adverse effects such as an irritation or a burning sensation in oral mucosa and also discoloration of teeth or mucosa. , It seems that CHX gel due to the local placement within the alveolar socket and a single-dose administration may alleviate such adverse effects.
The aim of present study was to systematically review pervious randomized controlled trials (RCTs) on the efficacy of bioadhesive CHX gel in reducing of AO occurrence.
| Materials and Methods|| |
Electronic searches were performed using "alveolar osteitis" and "chlorhexidine" as key words for title and abstract in medical subject headings (MeSH) word search. References of each article were also reviewed.
This review study has been searched up to 28 February 2014 in Medline/PubMed, Scopus, EBSCO, Ovid and Cochrane central registry for controlled trial by searching mentioned key words. A total of 43 studies were found. PubMed query translation was "dry socket" [MeSH] or "alveolar osteitis" [MeSH], and "chlorhexidine" [MeSH]. The search through Medline and Cochrane central register for control trial listed out 37 and 17 articles, respectively, which all overlapped with the results found in PubMed.
Inclusion criteria were limited to the journal articles in prospective RCTs in English language. Articles were excluded if they did not fulfill one or all of the inclusion criteria, if no control group (e.g. placebo (any material different from CHX gel), rinse, and no intervention) was used, and if the outcome of interest was other than incidence of AO.
The outcome measure was set on incidence of AO.
For data extraction, we designed a check list, regarding AO and CHX gel including author, year, country, sample size, study design, and main outcomes of each study [Table 1]. Two authors [Mahmood Reza Kalantar Motamedi and Saber Khazaei], who were not blinded, performed all searches and review procedures from the beginning to the end, independently. In the case of disagreement between evaluators, it reassessed by discussion and a final consensus was agreed on. [Figure 1] provides information on the number of papers identified through the search strategy. Moreover, cross-references were screened to identify further trials that probably were missed through the search strategy. However, no additional trials were found.
The data were analyzed using review manager software (version 5.2). Inverse-variance weighting was implemented to calculate the random effect summary estimates and to produce a forest plot using the number of participants with events and total number of participants in experimental and control groups of each study.
| Results|| |
Out of initial 43 articles, seven letters to the editor (comments on previous studies), nine reviews, nine studies due to lacking relevance to the subject, and 10 articles because they had evaluated CHX rinse (CHX gel was not tested) were excluded. Among eight remained articles, the full texts were obtained, and they were considered based on compliance with exclusion/inclusion criteria. Finally, seven RCTs ,,,,,, fully met the criteria for detailed analysis. The reasons for excluding the one study was that Rodríguez-Pérez et al., did not used any placebo gel, in fact, they compared two different amounts of CHX gel (1 and 0.2%) without using another control group using some materials different from CHX gel.
CHX (0.2% concentrations) after surgery prevented 72% of AO (OR = 0.28, 95% confidence interval (CI): 0.18-0.44; P < 0.001) (seven trials, 593 participants) [Figure 2]. Also, the prevalence of dry socket varied from 6.67 to 32.5% in surgically extracted third molars. Out of the selected RCTs, two studies had a split-mouth design and five did not have. Four and two trials were performed in Spain and Iran, respectively, with same study authors [Table 1].
|Figure 2: Forest plot of comparison between CHX gel versus placebo; CHX = Chlorhexidine; M-H = Mantel-Haenszel, 95% CI: 95% confidence interval, df: degree of freedom|
Click here to view
| Discussion|| |
This meta-analysis study was carried out to review and study the efficacy of bioadhesive CHX gel compared with placebo used to reduce the incidence of AO in patients who were candidate for bilateral tooth extractions. Considering this searching strategy, seven articles met the criteria for final evaluation. Based on these studies, a single-dose administration of 0.2% bioadhesive CHX gel reduces the incidence of AO.
Several factors can increase the risk of AO incidence such as tobacco smoking, ,, drinking,  herpes,  level of tooth impaction, , periodontal problems, , poor oral hygiene, ,, surgical site, , preoperative infection, , aging, , female gender, ,, use of local anesthesia with a vasoconstrictor, , ingestion of oral contraceptives, ,, traumatic exodontias, , and lack of experience in the surgeon. ,,, However, the results are controversial  and statistical analyses are mostly inadequate as only a few studies have conducted multivariable analyses. ,,, In a great number of previous studies, such risk factors were included. Therefore, when evaluating the role of CHX in reducing AO incidence, these risk factors can serve as confounding variables. Most of the selected studies included analgesic and antibiotic medications, contraceptive pills, and smoker patients. ,,,, In two included trials with split-mouth design, , the main risk factors comprised smoking and receiving contraceptives; however, due to the use of split-mouth design, the role of confounding variables might be controlled. Haraji et al., , were in this opinion as well, which stated due to the split-mouth design, the variables gender, age, receiving contraceptives, different oral hygiene, and smoking were equal in the treatment and control groups.
It is worth mentioning, Haraji et al., , extracted the teeth with similar surgery difficulty index in both sides of a mouth. This may lead to a further accurate and calibrated split-mouth evaluation. However, of the Haraji's et al., , limitations, although most of confounders were limited in their studies, enrolling only patients who could tolerate postoperative pain without analgesic consumption might be questionable, as the results might not be generalizable to the routine clinical practice.
A proposed responsible factor regarding incidence of AO was microbial agents that may contribute to fibrinolysis and consequent blood clot disintegration.  Several studies have focused on reducing the incidence of AO by decreasing bacterial count in oral cavity.  Therefore, the fact that CHX can reduce the frequency of AO might be due to its broad spectrum of activity versus oral aerobes and anaerobes. ,
A limitation of our study was that only relevant studies in PubMed/Medline, Scopus, EBSCO, Ovid and Cochrane library were searched. The authors suggest for future surveys to utilize split-mouth design with a more control on included AO risk factors.
In conclusion, bioadhesive CHX gel can reduce incidence of AO.
| References|| |
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Berwick JE, Lessin ME. Effects of a chlorhexidine gluconate oral rinse on the incidence of alveolar osteitis in mandibular third molar surgery. J Oral Maxillofac Surg1990;48:444-8.
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Larsen PE. The effect of a chlorhexidine rinse on the incidence of alveolar osteitis following the surgical removal of impacted mandibular third molars. J Oral Maxillofac Surg 1991;49:932-7.
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Hita-Iglesias P, Torres-Lagares D, Flores-Ruiz R, Magallanes-Abad N, Basallote-Gonzalez M, Gutierrez-Perez JL. Effectiveness of chlorhexidine gel versus chlorhexidine rinse in reducing alveolar osteitis in mandibular third molar surgery. J Oral Maxillofac Surg 2008;66:441-5.
Torres-Lagares D, Gutierrez-Perez J, Infante-Cossio P, Garcia-Calderon M, Romero-Ruiz M, Serrera-Figallo M. Randomized, double-blind study on effectiveness of intra-alveolar chlorhexidine gel in reducing the incidence of alveolar osteitis in mandibular third molar surgery. Int J Oral Maxillofac Surg 2006;35:348-51.
Torres-Lagares D, Gutierrez-Perez JL, Hita-Iglesias P, Magallanes-Abad N, Flores-Ruiz R, Basallote-Garcia M, Gonzalez-Martin M. Randomized, double-blind study of effectiveness of intra-alveolar application of chlorhexidine gel in reducing incidence of alveolar osteitis and bleeding complications in mandibular third molar surgery in patients with bleeding disorders. J Oral Maxillofac Surg 2010;68:1322-6.
Torres-Lagares D, Infante-Cossio P, Gutierrez-Perez JL, Romero-Ruiz MM, Garcia-Calderon M, Serrera-Figallo MA. Intra-alveolar chlorhexidine gel for the prevention of dry socket in mandibular third molar surgery. A pilot study. Med Oral Patol Oral Cir Bucal 2006;179:84.
Daly B, Sharif MO, Newton T, Jones K, Worthington HV. Local interventions for the management of alveolar osteitis (dry socket). Cochrane Database Syst Rev 2012;12:CD006968.
Flötra L, Gjermo P, Rölla G, Waerhaug J. Side effects of chlorhexidine mouth washes. Scand J Dent Res 1971;79:119-25.
Gürgan CA, Zaim E, Bakirsoy I, Soykan E. Short-term side effects of 0.2% alcohol-free chlorhexidine mouthrinse used as an adjunct to non-surgical periodontal treatment: A double-blind clinical study. J Periodontol 2006;77:370-84.
Haraji A, Rakhshan V. Single-dose intra-alveolar chlorhexidine gel application, easier surgeries, and younger ages are associated with reduced dry socket risk. J Oral Maxillofac Surg 2014;72:259-65.
Haraji A, Rakhshan V, Khamverdi N, Alishahi HK. Effects of intra-alveolar placement of 0.2% chlorhexidine bioadhesive gel on dry socket incidence and postsurgical pain: A double-blind split-mouth randomized controlled clinical trial. J Orafac Pain 2013;27:256-62.
Babar A, Ibrahim MW, Baig NJ, Shah I, Amin E. Effcacy of intra-alveolar chlorhexidine gel in reducing frequency of alveolar osteitis in mandibular third molar surgery. J Coll Physicians Surg Pak 2012;22:91-4.
Rodríguez-Pérez M, Bravo-Pérez M, Sánchez-López JD, Muñoz-Soto E, Romero-Olid MN, Baca-García P. Effectiveness of 1% versus 0.2% chlorhexidine gels in reducing alveolar osteitis from mandibular third molar surgery: A randomized, double-blind clinical trial. Med Oral Patol Oral Cir Bucal 2013;18:e693-700.
Abu Younis MH, Abu Hantash RO. Dry socket: Frequency, clinical picture, and risk factors in a palestinian dental teaching center. Open Dent J 2011;5:7-12.
Kolokythas A, Olech E, Miloro M. Alveolar osteitis: A comprehensive review of concepts and controversies. Int J Dent 2010;2010:249073.
Halabí D, Escobar J, Muñoz C, Uribe S. Logistic regression analysis of risk factors for the development of alveolar osteitis. J Oral Maxillofac Surg 2012;70:1040-4.
Parthasarathi K, Smith A, Chandu A. Factors affecting incidence of dry socket: A prospective community-based study. J Oral Maxillofac Surg 2011;69:1880-4.
Cardoso CL, Rodrigues MT, Ferreira Júnior O, Garlet GP, de Carvalho PS. Clinical concepts of dry socket. J Oral Maxillofac Surg 2010;68:1922-32.
Baqain ZH, Karaky AA, Sawair F, Khaisat A, Duaibis R, Rajab LD. Frequency estimates and risk factors for postoperative morbidity after third molar removal: A prospective cohort study. J Oral Maxillofac Surg 2008;66:2276-83.
Oginni FO, Fatusi OA, Alagbe AO. A clinical evaluation of dry socket in a Nigerian teaching hospital. J Oral Maxillofac Surg 2003;61:871-6.
al-Khateeb TL, El-Marsafi AI, Butler NP. The relationship between the indications for the surgical removal of impacted third molars and the incidence of alveolar osteitis. J Oral Maxillofac Surg 1991;49:141-5.
Benediktsdóttir IS, Wenzel A, Petersen JK, Hintze H. Mandibular third molar removal: Risk indicators for extended operation time, postoperative pain, and complications. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004;97:438-46.
Meechan J, Venchard G, Rogers S, Hobson R, Prior I, Tavares C, et al.
Local anaesthesia and dry socket. A clinical investigation of single extractions in male patients. Int J Oral Maxillofac Surg 1987;16:279-84.
Eshghpour M, Rezaei NM, Nejat A. Effect of menstrual cycle on frequency of alveolar osteitis in women undergoing surgical removal of mandibular third molar: A single-blind randomized clinical trial. J Oral Maxillofac Surg 2013;71:1484-9.
Chuang S-K, Perrott DH, Susarla SM, Dodson TB. Age as a risk factor for third molar surgery complications. J Oral Maxillofac Surg 2007;65:1685-92.
Hermesch CB, Hilton TJ, Biesbrock AR, Baker RA, Cain-Hamlin J, McClanahan SF, et al
. Perioperative use of 0.12% chlorhexidine gluconate for the prevention of alveolar osteitis: Efficacy and risk factor analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:381-7.
[Figure 1], [Figure 2]

domain: medical


text:
not sure. that i know for sure. when do i know something - when i am sure of it.
maybe the task is to seek out what is worth searching for. i remain me and will always remain so - even after this body is no more. my mind with its feelings and thoughts and images and sensations - is still something foreign to me. i will remain after that is changed. as is all - all is change all the time - change is the only constant - other than me of course. me constant - change without may be the better way to define it.

domain: literature


text:
Estimated read time: 3-4 minutes
This archived news story is available only for your personal, non-commercial use. Information in the story may be outdated or superseded by additional information. Reading or replaying the story in its archived form does not constitute a republication of the story.
LOGAN — So nice, he said it twice. The plan: Stop Kerwynn Williams.
That is the idea San Jose State University head coach Mike MacIntyre has instilled in his team for the upcoming game against Utah State. For good reason, too. Williams leads the WAC in rushing yards and is in the top 10 in receiving yards. But San Jose State (4-1) knows that USU (4-2) is more than just a running offensive team. It has a great defense as well, second in the WAC in sacks trailing only San Jose State.
Date: Saturday, Oct. 13, 2012 Kickoff: 2:07 p.m. (MT) Location: San Jose, Calif. Stadium: Spartan Stadium (30,456) Series: Utah State trails, 13-20-1 TV: ESPN Regional (Altitude) Trey Bender (Play-by-Play) Jay Taylor (Analyst) Radio: Utah State Sports Network Al Lewis (Play-by-Play) Craig Hislop (Analyst) Live Stats: UtahStateAggies.com Twitter Updates: /USUFootball YouTube: /USUAthletics Facebook: /USUFootball Tickets: 1-877-SJSU-TIX
SJSU will host USU at its own homecoming on Saturday, Oct. 13, to open conference play. Kickoff is set at 2:00 p.m. MT and will be televised on ESPN Regional.
MacIntyre said some positive things about SJSU's opponent this coming weekend. Here's what he had to say.
Thoughts on Utah State overall:
"Utah State has the No. 8 scoring defense in America. It has the WAC all-purpose yards leader in Kerwynn Williams. Excellent, excellent football player. So we've got our work cut out for us. It's going to be a great game and we're looking forward to it."
On Utah State's offensive weapons:
"Williams is a really good football player. We just need to know where he is. They throw it to him. He runs it. He has a lot of speed and athleticism. And Chuckie Keeton, the quarterback, is second in the league in passing. He moves around. He's a very athletic quarterback. He's able to move around and not stay in the pocket. He reminds me a little bit of a quarterback at San Diego State that can run around and make some plays. He has done a great job with their offense. They're moving the ball well. They had a tough time against BYU, but everyone has had a tough time against BYU."
On Utah State's defense:
"I think Utah State's defense is excellent. They're eighth in the nation in scoring. I don't think anybody scored a touchdown on them in the first half, which is unheard of after six football games. They've proved it over the last six football games that they're a top 10 defense in America. And that's something we're going have to deal with, and we're going to have to move the ball. Hopefully we score a touchdown in the first half and throughout the game."
On what to expect offensively for Saturday's game:
"I expect a great game. I don't know if it'll be high-scoring or low-scoring. I think it all depends on the flow of the game and how everybody reacts. But I do think you will see two really good football teams playing. Usually that equates into a littble bit of scoring because I think they have some playmakers and I think we have some playmakers, and I don't know if you can always hold them down on both sides of the ball continuously. And I know they'll find a way to try to get the ball to Williams more than they did last week, because when he carries the ball and catches the ball and does things, they seem like they're pretty successful."
Alex Rivera is the assistant sports editor of the UVU Review. You can contact him at firstname.lastname@example.org or through his Twitter account @A_River_Uh.

domain: news


text:
🌟 Introducing The Hotel Victoria Mews: Your Perfect Investment Opportunity! 🌟
Discover a timeless gem in the heart of the city - The Hotel Victoria Mews! With 11 charming rooms, a central location, and a plethora of amenities, this is not just a property; it's a golden opportunity for you to make your mark in the hospitality industry. Don't miss your chance to own a piece of history and an incredible business venture rolled into one.
🏨 Centrally Located Excellence: Nestled in the bustling CBD, The Hotel Victoria Mews boasts a prime location that is second to none. Situated just 500 meters from the prestigious Rhodes University, this establishment is perfectly positioned to cater to the academic community and beyond. With public parking conveniently adjacent, guests can enjoy stress-free arrivals and departures.
🏊♂ Relaxation and Culinary Delights: Imagine your guests enjoying a refreshing dip in the pool after a day of exploration. Picture them relishing gourmet meals in the 60-seat restaurant, an experience that's more than just dining - it's a journey of flavours. The adjacent takeaway, abuzz with activity, adds a modern twist to convenience. And that's not all! Envision a retail section harmoniously linked to the pool and bar, where guests can shop for treasures to remember their stay.
🎉 Events, Entertainment, and History: Hosting events and conferences has never been easier, thanks to the dedicated conference room near the hotel entrance. Your guests can connect effortlessly with the available Wi-Fi, making business a pleasure. Meanwhile, the outside entertainment area and braai facilities around the pool set the stage for unforgettable gatherings. The hotel's history dates back to 1849, with "The Vic" bar - a legendary establishment where students once sowed their wild oats. Owning this property means becoming a steward of its rich legacy.
💰 Irresistible Investment: The Hotel Victoria Mews comes fully furnished and equipped, ready for you to step in and make your mark. The asking price of R6,995,000 is a remarkable opportunity in itself, but we're open to offers starting from R5,000,000. This is your chance to secure a lucrative business venture with tremendous potential for growth and success.
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Steve Birt, 083 656 8810, firstname.lastname@example.org

domain: travel


Bad news for Poland’s government: a central banker it was eager to replace will stay on the country’s rate-setting panel.
A Polish appeals court Friday overturned a defamation conviction against Jan Winiecki, in a ruling that will allow the inflation-averse official to remain on the job. By vacating Mr. Winiecki’s lower-court conviction on charges of defaming a now-dead central-bank governor, the appellate judge effectively closed the door on speculation he could be replaced by someone more likely to cut interest rates.
Under Poland’s central-bank law, members of the Monetary Policy Council, on which Mr. Winiecki has served since 2010, are dismissed in the event of a criminal conviction.
Poland’s government has been vocal in pushing the central bank to more aggressively ease monetary policy to boost economic growth. Analysts had expected the government to seize the opportunity to select a banker more sympathetic to its views if Mr. Winiecki were removed. Poland’s Prime Minister Donald Tusk on Thursday said he wanted to have a say in the appointment of Mr. Winiecki’s replacement.


text:
Long multicolored mittens with a thumb gusset.
This pattern is great for colorplay. I use six different colors in my charts, but that does not mean you cannot use more or less colors. If you don't like the idea of weaving in ends (there'll be a lot of those!), try some color-changing yarn over solid color, just make sure the contrast is strong.
The pattern is written for circular needles (magic loop method), adjust if using DPNs.
I am currently working on Lubava gloves pattern, hope to post it soon.

domain: hobby


text:
Inheritance of mitochondrial disease determined when mother is still an embryo
The risk of a child to inherit mitochondrial diseases – i. e. malfunction in what is usually referred to as the power plants of the cell – is largely decided when the future mother herself is still an embryo. This according to a novel study by scientists at Karolinska Institutet and the Max Planck Institute in Germany, which is published in the journal Nature Genetics.
Mitochondria are small structures within almost every cell in the body, responsible mainly for energy production and fat metabolism. Their function is very important, and they contain their own genome, called mitochondrial DNA (mtDNA). The mitochondrial genome is inherited via the mother, where hundreds of thousands of mtDNA copies are packed in the female germ cell.
"Mutations in the mitochondrial genome can cause a variety of severe diseases, such as muscle weakness, neurodegenerative diseases, heart disease and diabetes", says Christoph Freyer, one of the study authors. "Many of these diseases only develop once a certain ratio of mutant and normal mtDNA molecules is reached within the cell. It is therefore important that we learn more about how mtDNA is inherited from mother to child."
A mother carrying a mutation in her mitochondrial genome can pass on a mixture of normal and mutated mtDNA to her children, but what determines the levels inherited and the driving force behind this mechanism is poorly understood. In the current study in Nature Genetics, scientists generated a novel mouse model, carrying a pathogenic mutation in the mitochondrial tRNA methionine gene.
Three different phases
This allowed the group to look at the ratio of mutated to non-mutated genes, or mutation level, in three different phases of the hereditary process. First they analysed germ cells from mouse embryos and established how the degree of mutation varies from germ cell to germ cell. After birth they looked at that degree in the immature egg cells of the mouse. And later they examined the degree of mutation in the mtDNA of the offspring.
The analysis shows, that in contrast to the protein-coding genes, shown by recent research to be subject to prenatal selection, tRNA genes are not selected out by the female germline. So whether and to what extent mutant genes can be transmitted to the next generation is decided when the future mother is still herself an embryo, during the development of her germ cells. Mutant genes often coexist with normal genes, a condition called heteroplasmy, in the affected egg cells. In other words, mutated and non-mutated genes occur in each egg cell in a particular ratio and thus the mutation may or may not be transmitted to the next generation. This also explains the differences arising within a family.
At the same time, the scientists note that the mitochondria in these mice try to compensate for the defect, giving further insight into the hereditary mechanisms underlying mitochondrial disease.
"Understanding the signals required for this compensation will potentially help in treating mitochondrial disease, which is very exciting", says Christoph Freyer.
The study is the result of a collaboration between Karolinska Institutet, the Max Planck Institute for Biology of Ageing in Cologne, Germany, and the University of Newcastle, United Kingdom. The works was funded by the Max Planck Society, the Swedish Research Council, the Leduqc Foundation, the ERC, and the NIH amongst others.
Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.
Nat. Genet. 2012 Nov;44(11):1282-5


At least four persons were killed in firing by federal security forces when a mob attempted to snatch their weapons outside a polling booth in election-bound West Bengal, triggering a blame-game between the eastern Indian state's ruling Trinamool Congress and Prime Minister Narendra Modi's nationalist Bharatiya Janata Party.
Police said that clashes broke out between a group of local residents and personnel of the para-military Central Indian Security Force in West Bengal's Cooch Behar district, following rumours that an aged man passed out after being thrashed by the federal troops at a polling booth in Sitalkuchi, about 680 km from state capital Kolkata.
"Actually the man who had come to vote fainted, and his treatment was going on across the booth. As rumours spread, locals thought he was beaten by the central forces. A mob soon gathered and tried snatching weapons from the federal troops," police officer Debasish Dhar told the local media.
In self-defence, the Central Indian Security Force personnel opened fire, in which four men, including a first-time voter, died, another police officer said. "The Election Commission of India has stopped polling at the booth in Sitalkuchi and sought a detailed report from the local administration."
Both the Trinamool Congress and the BJP were, however, quick to blame each other for the four deaths.
While Bengal Chief Minister and Trinamool Congress supremo Mamata Banerjee accused the central security forces of "planned murder" and demanded Indian Home Minister Amit Shah's resignation, Prime Minister Modi apparently attributed the clashes to the "goons of Trinamool".
"Home Minister Amit Shah is completely responsible for the incident and he himself is the conspirator. I don't blame central forces because they work under the Home Minister's order. We will demand his resignation," Banerjee said at a press conference in the evening, calling the deaths "murder by central forces".
On the other hand, Prime Minister Modi, currently campaigning in the state, slammed Chief Minister Banerjee and her party for the violence. "What happened in Cooch Behar is sad... I offer condolences to bereaved families. Mamata Didi and her goons are jittery because of groundswell of support for the BJP," he said.
However, Banerjee soon hit back at Modi. "The BJP knows it won't win so it's resorting to bombs and violence. The central forces are torturing people in villages. Women, boys and girls are being threatened that they should vote for the BJP. In the state election, 20 people have been killed so far and 13 of them are from our party," she said.
West Bengal is currently witnessing the most high-profile contest in India's ongoing state elections. While Chief Minister Banerjee has harped on being Bengal’s daughter, the BJP has been asking people to vote for "change and socio-economic development" after nearly 50 years of Communist and Trinamool Congress rule.


text:
Championship Weekend Rumford-Riverside Littlers
All East Providence Final in 9-10 Little League Tourney
Mid-summer means all-star play and the district features a 9-10 year old tournament. District Two is the largest of the state's four Little League districts. Teams participating in the double-elimination tourney are Riverside, Rumford, Tiverton, Barrington, Warren, Portsmouth, Newport, King Phillip, Pineview and Darlington Americans. It is mandatory that each player is in the field for at least 6 outs and has at least 1 at bat regardless of the number of players on the roster.
The tournament is named the Ron Silva 9-10 District Two Tournament. Ron Silva was a long time Riverside Little League volunteer and a District Two official. The 2018 tournament has been exciting and will culminate this weekend, July 28 and 29. Two East Providence teams have reached the finals. Rumford will play Riverside Saturday at 5:45 pm at the Kim Rock Little League complex in Rumford. Rumford, playing from the winner's bracket with a 3-0 tourney record, can win the tournament with a Saturday win. Rumford has defeated King Phillip, Pineview and Warren to reach the finals.
If Riverside wins on Saturday, the championship game will be played at 5:45 pm on Sunday at the Riverside Forbes Field little league complex. Riverside was thrown into the loser's bracket with an opening round loss to Warren on July 2nd. However the Riverside club stormed back to reach the finals with 5 impressive wins over Barrington, Portsmouth, Pineview, Darlington and a 10-1 win over Warren, avenging that earlier loss.
"These boys continue to work hard. A great 10-1 win over Warren, the team that sent us to the losers bracket in game 1. They have worked hard and not given up. On to Rumford Saturday for the final series," said Riverside coach Kris Hallene.
"Our kids have had a great time. Especially that big win over Warren. Down 5 - 1 heading into the 5th inning, we came back to tie the game and went on to win 6 - 5 in extra innings. Great plays in the field and clutch at bats for both teams as well as some timely pitching. On to the championship this weekend," said Rumford coach Eddie Wencis.
Indeed, on to the Rhode Island 9-10 District Two Championship. It's an all East Providence party. Bring an appetite for baseball and food. Both leagues have extensive concession stands. A win-win for the locals.


Vodafone has urged the UK government to act to ensure access for mobile companies to a new publicly funded wireless network being built by its rival EE.
Vodafone has been frustrated that EE, which won the £1.2bn contract to transfer police, fire and ambulance communications to its 4G network in 2015, has not provided detailed information on where the majority of its new masts in rural areas will be located.
It has written to the Home Office to call for a fully transparent process to be established to monitor the project. It has suggested a similar process to that used for BDUK, the programme for delivering subsidised funds to roll out fibre networks in rural areas.
The “blue lights” network, which replaces the dedicated Airwave network, has to be opened up to EE’s rivals to increase mobile coverage in rural areas. The government received European Commission approval for the publicly funded network to avoid state aid restrictions.
Yet EE has been slow to provide its rivals with the information. That detail is critical for Vodafone, O2 and Three to decide whether they want to install their own equipment on new masts better to cover rural areas. BT, which owns EE, said last month that it had received planning permission for “99 per cent” of the sites needed to fulfil the emergency services network.
Vodafone said that until last month, it had received information on only two sites from EE, despite the Welsh and Scottish governments handing over an entire list of mast locations for the towers that they will install. One of the EE sites was a “pole on an end of a barn in Cumbria” which would be unsuitable to support equipment from other networks. Details of a further 27 sites were submitted at the start of February, but that represents only around 10 per cent of the total mast estate being built by EE.
A Vodafone spokesman said: “EE has offered up just 29 from a possible 200 to 300 sites it could build with taxpayers’ money. We can only assume that this apparent indifference to parliamentary advice and the use of public money is deliberate.”
A spokesman for EE dismissed Vodafone’s concerns and said that consulting over every site would slow down the rollout of the emergency services network (ESN). “We are not being obstructive [but] they [Vodafone] are not our priority,” he said.
EE said its priority was hitting the emergency services’ contract deadline. It added it expected to hand over information on more than a hundred rural masts “within months”.
The Airwave contract comes to a hard stop in 2020 and any delays to the EE network being launched could cost the taxpayer hundreds of millions of pounds to maintain the old network, which uses Vodafone’s access network.
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So the only way all the brake lights can be on is if there is voltage flowing through the switch or if there is a short to power somewhere in the wiring before any of the lamps so that the voltage would go to all the lamps.
We need to measure voltage before and after the switch and see if there is any there. If there is, either you got a faulty switch or the brake switch is depressed (plunger sticking) which is actually letting the brakes stay on. This means it will need to be adjusted.
Let me know if you have questions and we can go from there. Thanks.
Images (Click to make bigger)
Thursday, November 14th, 2019 AT 5:56 PM


Rear door for Suzuki and Santana Jimny, petrol or diesel from 1998 to 2018, sheet metal. Delivered without accessories. Raw product to paint. Quality: original
Fixes the interior door panels on Suzuki or Santana 410, 413, Samurai, petrol, diesel and turbo diesel.
Fixes the door’s bottom moulding.
Purchase a gift voucher


my 1st friend gave me 1000 and 2nd gave me 500 i have loos 1000 rupees then i purchase some thing with the cost of 300 and gave 100 100 both friends 1st friend remaining 900 and 2nd remaining 400 900+400+300=1600 why58 317019
1. What are good characteristics of good combustion in a boiler? 2. What do you analyze from boiler water analysis? 3. What do you treat in high alkalinity of boiler water? 4. What is a feed water pump? Dearator feed heater? 5. What is the purpose of the nozzle of impulse turbine? 6. What are the things needed to have an efficient boiler burning? 7. Name Of Parts And Each Purpose 8. What are the causes of emergency stop in a steam engine? 9. What is the normal vacuum pressure in a steam turbine atmospheric condenser? What would cause the press to falls? 10. Steam turbine (function an parts) 11. What is the boiling point of water? 12. What are the safety devices of boiler? 13. What is the effect of high alkaline water to a boiler? 14. Steps In starting boilers. 15. Small gear found in the steam turbine. 16. What is an Economizer? 17. What are the methods of heat transfer? 18. Types of pressure 19. What are the different parts of impulse reaction turbine? 20. What is the color of the flame of the boiler running in good condition? 21. What type of pump is commonly used is feed water system in auxiliary boiler? 22. What is the specific heat of water? 23. What do you do to prevent flare black? 24. What is a brake horsepower? 25. What is the purpose of a de-superheater? 26. What is the purpose of corrugated furnaces? 27. What are the causes of steam turbine failure? 28. What is the purpose of superheater? 29. Given a cutaway isometric view of the steam turbine. Examinee was asked to identify the following Parts: 30. What is thrust bearing? 31. Give five boiler mounting valves. 32. In steam boiler, what are the various test in water boiler? 33. How much calorific value of heat is needed to heat 00c of 34. What will happen if boiler backfires? 35. What is the color of flame if the boiler is running in good condition? How about when it is not in good condition? 36. How does the steam work in a steam turbine? 37. What are the causes of boiler backfire and steps in how to prevent it from happening? 38. What are the causes of high alkalinity in boiler water? 39. What are sensible heat, latent heat, and specific heat of water? 40. What are the causes of turbine vibration 41. Identify the parts of steam turbine 42. What is the normal Ph value of boiler water 43. Causes of dilution of lubricating oil in a steam turbine? 44. Explain briefly- good combustion of auxiliary boiler? 45. Method of testing or checking boiler water? 46. What is mean carry over of Aux. Boiler? 47. What are steam turbine parts usually come into damage? 48. Why must we pay attention when we drain steam in steam turbine. What factors are observed? 49. What type of pump use in boiler F.O. system? 50. What parameters to be reported when we send lubricating oil for shore analysis? 51. In boiler, what does steam and smoke goes out to the funnel. What reason? 52. Where can you find the feed check valve and feed stop valve and give the purpose of it? 53. What are the causes of troubles in boiler during operations? 54. Give the purpose of nozzle in impulse turbine? 55. What s gland sealing steam? 56. How to prevent back fire of boiler? 57. What is the used of economizer in boiler? 58. What is the seal packing gland for turbine? 59. What is the flow of steam in an impulse turbine? 60. What will happen if you blow the soot in the boiler? 61. State the purpose of air heater? 62. How to operate soot blower boiler and economizer? 63. What do you mean by A.CC.? 64. What is the thermal efficiency of a diesel engine? 65. What is a blow down valves?
what is the difference between toggle checkpoint and checkpoint?
the official time (working hours) of juan magalang is 7:00 am to 4:00pm.lunch break is one hour that is from 12:00-1:00pm. the management allows a grace period of 10 minutes for lates. more than 10 minutes late is deducted one hour as punishment. juan works from monday to friday his official time are as follows. am pm overtime in out in out in out monday 7:05 12:05 1:00 4:05 tuesday 6:59 12:01 12:58 4:03 wednesday 7:15 12:04 12:56 4:00 thursday 6:56 12:01 1:05 4:00 4:00 10:00 friday 7:01 12:10 12:50 4:05 his daily rate is 404 pesos, this include the COLA. if SSS deduction is 100 pesos per month Philhealth contribution is 100 pesos and Pag-ibig fund is 100 pesos. if he is married with 2 kids ages 10 to 12 years old how much tax will be deducted from his income? assuming payroll is every 15th and 30th of the month, compute for his take home pay, if tax,SSS, Pag-ibig and Philhealth are deducted on the 15th of the month, how much will be received on the 15th and 30th assuming table shown are the same for the three other weeks.
composition of cast iron fc-500,fc-550,& fc-260 which is use in sheet metal industries as a piller set
What are the two or three key features you plan to add? - Venture Capitalists
c program for searching a student details among 10 student details
Write the test cases for godaddy home page
First round was HR round. The questions asked were: Tell me about yourself? Where were u born and brought up? I'l give u a sentence like a "walk in the park" or "walk in the vegetable market". Now frame a short story around it. Next was aptitude round, where 1 logical question such as "A works not in mangalore, not in mysore. B works in Mysore and not in mangalore, not in bangalore. C works in Mangalore. Then where does A work?" The rest were simple english questions and a passage was given and some questions asked from it. Next was technical round. The questions asked were: What is an IP address? What are the different types of networks(A,B,C,D,E) Can u tell me the address range of A,B,C,D,E networks? Why do we use these different networks? What is static Ip address? What is Dynamic IP address? How do we find out the IP address from your computer? What is the use of DNS? Next was OPS round. The questions asked were: Tell me more about yourself. What are ur expectations from the job? Describe success in terms of job? What is ur ideal job? Are u comfortable to work in night shifts? Sometimes a person younger to u might be in a better position. Are u comfortable taking directions from him? What is ur expected salary? If the software sector booms, Would u change ur job?
wat is mass allocation and when it is used
How to Sort Strings which are given in List and display in ascending order without using java api.
Can any one know what are the symbols at the down (below) the analog ammeter??? there are 4 symbols which are they ?????
Business communication is very vital for successful business organization in the globalization era discuss
How to size fuse? How to size MCB?
What are the safety devices that are fitted in a refrigeration system?
in block masonry l=10',b=0.5',H=10',Calculate cement ,sand and no.Of blocks?


text:
Sunshine State Survey: Water is environmental issue of greatest concern to voters
USF's school of Public Affairs and Nielsen's latest results on their annual
Sunshine State Survey were released on Sept. 30th, asking how Floridians feel about crime and environmental issues.
USF Political Scientist Dr. Susan MacManus said Floridians believe Florida's biggest environmental issue is water.
"What is the biggest environmental problem facing Florida, hands down it's water, water-related problems," she said. "Specifically, 32 percent - almost the third - mention either the quality or the shortage of water."
The Sunshine State Survey shows Floridians are now more critical of the state's job protecting the environment since the 2012 survey. Only one-third of those polled believe the state is doing a good job.
When asked to identify “What is the biggest
environmental problem facing Florida today?” 39%
of the respondents refer to a problem involving
water; 19% cite a pollution problem; 8% mention a
political problem; another 7% point to potential
disasters stemming from humans or nature; food
production-related problems are the top concern
of 2%, while 6% cite a wide range of other
problems. Almost one-fifth (18%) gave no
response to the question, reflecting less general
knowledge of environmental challenges than of
those in some other policy areas.

domain: sociology


text:
… to when we were living on the sea in Egypt and shooting sharks for fun. Incredible times. Here’s my gorgeous wife Natalia filming an Oceanic White Tip.
Battling through the fierce winds - the DJI Mavic Pro 2 held it’s own and still managed to turn out some buttery smooth footage. Pretty incredible for a Drone that fits in your coat pocket!
It’s been a couple of weeks since the most incredible spontaneous trip to Iceland with my 6 year old. I’ve still got numerous photos to go through - but my usual commercial photography has taken hold. Gotta feed the fam! ha ha… so here’s a quick photo of the amazing Skogafoss waterfall. Back soon with more Iceland action!
Ok ok... I have to admit have been a little slack on the blog front recently! Only excuse was a round the world trip that was so much fun, the laptop was stored away for most of it! I'll be posting more now i'm back... so for starters here's a quick shot from a night in Singapore. I didn't take a tripod with me - so a 5 second exposure on a fence railing was precarious at best! Looking across to our hotel - The Marina Bay Sands was amazing enough... then they turned on the laser light show! Singapore - you rock!
Always a pleasure to be photographing a Grand Designs house. And it's always fascinating to hear the story of the owners and how they came to create their very own Grand Design. They have their own unique wood-working company - so it was fitting that they teamed up with Accoya (a raw Dutch wood product) to give their home it's own unique flavour.
Here's some photos from the shoot:
It's not just incredibly gorgeous artistic pieces of snowflake glory... it's snowflake multimedia heaven too! It's that good that I took my 4 year old round - after downloading the iphone app - and making it all come to life!
If you get the chance - don't miss the opportunity to see this fantastic art installment in Liverpool City Centre. Here's some marketing photos I nabbed for Open Culture - the event organisers...
Just going through some images from the new DJI Phantom 4 Pro Drone. And they are AMAZING. With a sensor size almost four times larger than the standard Phantom 4 - this Drone is setting incredible new benchmarks in image quality.
This is the one I had been waiting for- and it's now here!
What a beautiful part of the world to discover for a long weekend. On a bit of a whim we headed over to Germany to soak up some proper European festive cheer! Based in Nuremberg we also had a day trip out to the amazing Rothenburg. A beautifully preserved "Gingerbread House" town. So photogenic I found myself snapping madly in every direction! There's plenty more photos going up - so stick around!
The inaugural Liverpool Snowflake Trail is on! Some of Liverpool's most creative artistes have put their horse hair brushes to good use on some fantastically captivating Snowflakes arising from the pavement. Grab a Snowflake trail leaflet from any respectable Info office or retailer and use it as great excuse for a wander round the great little Liverpool Village!
One of my beloved clients - the Pullman Hotel Liverpool (part of the Accor Hotel group) are now getting set-up for super stylish weddings in Liverpool. With views over Albert Dock and the Mersey River... it is one of the best new venues in town. This photo above and more will be in a freshly pressed brochure available very very soon!
Am still reveling in the memory of this incredible location. Here's a quick video I pieced together with some of the aerial footage compiled on the trip. Enjoy!
In what is always such a fitting and moving tribute to the soldiers and military who have died. It's the faces that get me every time. Wherever you look there is a story to be told. Here is literally just a snapshot of the servicemen in Liverpool today.
"They went with songs to the battle, they were young.
Straight of limb, true of eye, steady and aglow.
They were staunch to the end against odds uncounted,
They fell with their faces to the foe.
They shall grow not old, as we that are left grow old:
Age shall not weary them, nor the years condemn.
At the going down of the sun and in the morning,
We will remember them."
This is an aerial photo of Albert Dock. Shot with a DJI Phantom 4 Drone. 27th October 2016. In the early 80's Margaret Thatcher wanted to tear it down as part of a "managed decline" operative for the city of Liverpool. Kinda glad she didn't get her way! These incredible buildings still stand majestically on the Mersey River. The afternoon light hitting them perfectly. Get on down and check them out if you're popping into Liverpool for a visit...
The Atlantic Container Line vessel - Atlantic Sea was christened successfully in Liverpool this week - and here's the photos to prove it!
Another magical day of photography in Liverpool - with the christening of the new Atlantic Container Line vessel - Atlantic Sea. HRH Princess Anne made a special trip up for the event - and I had the pleasure of photographing her visit. I've photographed her on 3 other occasions, which in comparison were rather hurried affairs. This day there was plenty of time for her to relax and enjoy the wonderful hospitality that Liverpool brings! As you can see from her many different expressions - she had a fantastic day!
Massive congratulations to the Museum of Liverpool for winning the best view in the UK and it was with this photo that they took the top prize... Always more than happy to help!
Travelling across Europe with a Drone sounds a little cumbersome and complicated - but it really is pretty straightforward. Grab yourself a small padded backpack off Amazon for around £40... then pack it inside your hardshell suitcase and forget about it till you arrive on a beautiful Greek Island. Once there get up nice and early and drive across the Greek countryside to a very very special place. Navagio Beach - or Shipwreck Bay as it's colloquially known. All the more special first thing in the morning before all the tourists hit it. This place is something else. Dramatic white chalky cliffs descend dramatically into the Aegean Sea. A boat that was once used to transport contraband washed up on the beach years ago. Culminating in a stunning spectacle. One of the most photogenic spots on the planet.
Here's a quick photo taken from the Drone to give you an idea.
One of my favourite venues on the planet - the Liverpool Cathedral. I first spotted Ben Fogle early in the evening looking a little lost. It was the first time he'd been in the cathedral and was in awe of the sheer size of it. He wandered over in the near darkness and asked me if I knew where the client was. So we wandered through the incredible structure to the ornate Lady Chapel where guests were arriving. Lovely guy, totally chilled and just how I expected him to be. It never ceases to amaze me just how many British people have never heard of, let alone set foot in, the Liverpool Cathedral. Here's a few photos from the evening.

domain: geography


TSI Incorporated Completes Expansion At Its Shoreview, Minnesota, Headquarters
TSI designs and manufactures precision measurement instrumentation from Dust Monitors to Particle Counters and Sizers. This two-story addition includes seven new conference rooms, eight engineering labs and a large meeting space that seats up to 500. As well as 26,000-sq.-ft. of additional manufacturing space. The completion of TSI’s 58,000-sq.-ft. expansion will bring the building’s total square footage to more than 200,000 sq. ft.
“Designed with an open, flexible layout of utilities to aid in lean manufacturing, this space was designed for future growth and the addition of new employees,” said Tom Kennedy, TSI Incorporated President.
2019 Top States for Doing Business: Georgia Ranks #1 Sixth Year in a Row
Hot Jobs: Growing Industrial Sectors
A Site Selector’s Checklist for Locating in the U.S.
Location USA 2019
Where to Invest in the Booming Aerospace Manufacturing Industry
2019 Auto/Aero Site Guide
Hiring Challenges Continue Throughout the U.S.
Tips for Navigating Incentives in Site Selection Process


Americablog provides an excellent analysis of what we know and don’t know about the leak of Plame’s name (and of course now so much more).
* Who authored the INR (State Department’s intelligence branch) memo, and why and how was it misleading?
* Who leaked the name, ‘Valerie Plame,’ and how did he or she receive that
* Who else was complicit in the worse crime of outing a clandestine CIA
officer? In the lesser crime of revealing classified information?
* What did the Vice President know, and when did he know it?
* What did the President know, and when did he know it?
* Why were people in the White House so afraid of what Joe Wilson had to say?


plyr: Tools for splitting, applying and combining data. plyr is a set of tools that solves a common set of problems: you need to break a big problem down into manageable pieces, operate on each pieces and then put all the pieces back together. For example, you might want to fit a model to each spatial location or time point in your study, summarise data by panels or collapse high-dimensional arrays to simpler summary statistics. The development of plyr has been generously supported by BD (Becton Dickinson).
Keywords for this software
References in zbMATH (referenced in 11 articles , 1 standard article )
Showing results 1 to 11 of 11.
- Yavuv, Fulya Gokalp; Schloerke, Barret: Parallel computing in linear mixed models (2020)
- Zhuang, Yonghua; Wade, Kristen; Saba, Laura M.; Kechris, Katerina: Development of a tissue augmented Bayesian model for expression quantitative trait loci analysis (2020)
- Kaplan, Andee J.; Hare, Eric R.: Putting down roots: a graphical exploration of community attachment (2019)
- Maurer, Karsten; Osthus, Dave; Loy, Adam: A tale of four cities: exploring the soul of State College, Detroit, Milledgeville and Biloxi (2019)
- McNamara, Amelia A.: Community engagement and subgroup meta-knowledge: some factors in the soul of a community (2019)
- Quach, Anna; Symanzik, Jürgen; Forsgren, Nicole: Soul of the community: an attempt to assess attachment to a community (2019)
- Niemi, Jarad; Mittman, Eric; Landau, Will; Nettleton, Dan: Empirical Bayes analysis of RNA-seq data for detection of gene expression heterosis (2015)
- Lawrence, Michael; Morgan, Martin: Scalable genomics with \textttRand bioconductor (2014)
- Gałecki, Andrzej; Burzykowski, Tomasz: Linear mixed-effects models using R. A step-by-step approach (2013)
- Kuhn, Max; Johnson, Kjell: Applied predictive modeling (2013)
- Hadley Wickham: The Split-Apply-Combine Strategy for Data Analysis (2011) not zbMATH


text:
The film, which was developed by Media Rights Capital, is a comedy about a man and his teddy bear.
The feature will mix live action and CG with MacFarlane also co-starring and providing the voice for the title character. The Hollywood Insider blog says the story centers on a seemingly normal man who, as a child, made a wish that he could talk to his bear, only to have his bear come alive.
The bear grows up alongside the man but one day the man’s girlfriend poses an ultimatum: her or the bear. Sources told HI that MacFarlane wants to cast Mila Kunis, who has voiced Meg Griffin on Family Guy since 1999, as the girlfriend.
MacFarlane wrote the script with Family Guy cohorts Alec Sulkin and Wellesley Wild. He will produce with MRC, Scott Stuber and John Jacobs.
Deadline says the plan is for the film to go into production this year.


text:
Members of the public are welcome to consult rare material at the Rare Books & Special Collections Library and at the Osler Library of the History of Medicine at no charge. To do so, please see the staff member at the front desk at either library. You will be asked to present a photo ID card and to fill out a registration form. The staff will create a McGill Library Consultation Card for you and show you how to submit an online request for the material. Material must be viewed on-site and staff will show you how to handle the items, which are often very delicate or fragile.
To save time, if you have several items to request, please ask us to retrieve the items ahead of your visit by emailing the rarebooks.library [at] mcgill.ca (Rare Books & Special Collections Library) or the osler.library [at] mcgill.ca (Osler Library of the History of Medicine). If you have already obtained your McGill Library Consultation Card, you may also place hold requests using the McGill Library Catalogue.
Note: Consultation Cards are valid only for consultation of rare items housed at these two libraries. The Consultation Card cannot be used to borrow books from the McGill Library.

domain: library


text:
*The world lost Marable Manning April 1.
He is one of the most prolific celebrated authors of the black experience.
He was in the process of writing yet another book, “Malcolm X: A Life of Reinvention”, when he passed away. The book was nearly completed and the most interesting aspects were already included.
According to Richard Prince’s Journal-isms, the author wrote about how Malcolm X’s assassination affected Alex Haley’s autobiography of Malcolm X.
Immediately following Malcolm’s assassination, the autobiography was in trouble. The deal had already been struck with Doubleday and Haley contacted the publishing company owned by Nelson Doubleday, to let them know (more…)


text:
The assets for Vigil Games, developers of the Darksiders series, were not sold at auction today and Vigil employees jobs have ended as the studio's fate remains part of THQ's Chapter 11 bankruptcy case, according to a letter from THQ CEO Brian Farrell.
"Some assets, including our publishing businesses and Vigil, along with some other intellectual properties are not included in the sale agreements," Farrell wrote in a letter to all THQ employees provided to Polygon by a former employee. "They will remain part of the Chapter 11 case. We will make every effort to find appropriate buyers, if possible."
Farrell sent the letter today as an auction took place in which THQ's games were sold title by title, but Vigil and its assets apparently failed to find a purchaser.
"If you are an employee of an entity that is not included in the sale, we regret that your position will end," Farrell wrote.
Polygon is in the courtroom and will update this story as more information becomes available. You can read more about the games and developers involved in our THQ Storystream below.

domain: economics