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The California-based advocacy organization, Oakland Institute, was quick to take note of Ethiopia’s State of Emergency, issuing a statement on Friday last week, typically describing the measure as “authorizing oppression.” With the its usual effort at misdirection, it began its comment: “The government of Ethiopia has responded to a groundswell of protests, which are calling for democracy and human rights for all, by imposing a six-month long state of emergency, effective October 8.” Over the next two pages it then manages to totally ignore the fact that the declaration of the State of Emergency followed the draft of proposals for change and reform outlined in the President’s speech to Parliament a few days earlier, notably, of course, proportional representation. The proposals detailed by the President are, of course, proposals that require peace and stability for implementation. In a piece of deliberate duplicity, designed to deceive, Oakland Institute even claims the State of Emergency does not address the situation on the country but merely “legalizes and expand the authoritarian and repressive rule that the Ethiopian regime has maintained for years.”
The Oakland Institute claims that the State of Emergency is “far-reaching”, though in fact the regulations it imposes is normal in a situation where the government is concerned that the sort of gross exaggerations and false information, peddled all-too-often by organizations like Oakland Institute itself, among others, appears intended to generate ethnic conflict. It is hardly accurate to describe as appalling an attempt to limit listening to the abhorrent and dangerous encouragement of violence that are regularly put out over the US and Europe-based ESAT TV station or over the Oromo Media Network. Similarly, to claim a ban on the provision of information to “international civil society groups” such as the Oakland Institute begs the question as to whether Oakland Institute has any right to describe itself in those terms, given its record of support for violent opposition in Ethiopian politics, its own manipulation of information and its efforts to end development aid to Ethiopia.
In its comments last week, the Oakland Institute managed within a page to misquote the Prime Minister, seriously exaggerate the number of deaths that occurred in a prison fire and repeat a whole number of its previously unconfirmed allegations. It also launches into its usual attack on Ethiopia’s Anti-Terrorism Proclamation of 2009, which no more violates international humanitarian law than do the anti-terrorist laws of the US, the UK and other states around the world. It also launches into its usual attack on Ethiopia’s donors, accusing the US, the UN , the EU and Canada of “toothless rhetoric”, for failing to condemn “the violence and repression,” and mocking their calls for peaceful or inclusive dialogue. It accuses donors of failing to acknowledge what Oakland Institute calls “years of oppression and abuse” and claims there is no one left for the government to talk with. It goes on: “For years, the US, UK, and others have heralded Ethiopia as a blueprint for development, and provided massive financial support to their champion. But the model has failed.”
Oakland Institute claims its most recent report “Miracle or Mirage? Manufacturing Hunger and Poverty in Ethiopia”, published last month, shows that economic growth in Ethiopia has “not lifted up the masses.” Surprisingly admitting for the first time that there has actually been growth in Ethiopia, it claims this has happened “alongside widespread hunger and poverty, forced displacements, and massive human rights abuses,” arguing that it is this that has led to the tensions in the country “finally, understandably boiling over.” It is this sort of statement that makes it very clear that Oakland Institute has no understanding of what has been happening in Ethiopia in recent months, or years, or why demonstrations have been taking place. Even by its own accounts “the widespread hunger and poverty and forced displacements” it claims have been occurring have not been happening in areas where there have been demonstrations. Nor does the Oakland Institute seem to have any knowledge of the way some of the demonstrations have been high-jacked by criminal or opposition elements deliberately aiming to cause violence.
These exaggerated and inaccurate claims are exactly what the Oakland Institute, making no secret of its dislike of the Ethiopian Government and of its development policies, has persistently produced in a number of reports, viciously, if inaccurately, attacking government policies and criticizing any, and all, organizations that have provided support to the country’s development efforts. Its targets include the World Bank, the UN the EU, the UK’s DfID and most countries that provide developmental assistance and aid to Ethiopia.
“Miracle or Mirage? Manufacturing Hunger and Poverty in Ethiopia,” fits squarely into this negative approach to development in Ethiopia, as its title underlines. Indeed, in its press release on the publication of the report on September 27, the Oakland Institute enthusiastically claims that “as months of protest and civil unrest hurl Ethiopia into a severe political crisis,” it is now debunking “the myth that the country is the new “African Lion”, exposing how authoritarian development schemes have perpetuated cycles of poverty, food insecurity, and marginalized the country’s most vulnerable citizens.” It says food shortages over the last year were widely attributed” to the El Nino phenomenon, but calls this “very convenient” for the government and its international backers who have been closely involved in Ethiopia’s development strategy. For the Oakland Institute, “the 2016 crisis is a harsh reminder that despite the trumpeted economic model, Ethiopia has not moved beyond its tragic history of chronic hunger and famine. Every year since 2005, 8 to 18 million Ethiopians have relied on food assistance for their survival.”
Ms. Mittal, Executive Director of the Oakland Institute, in an interview with VOA this month underlined these views, and indeed it appears her own hopes: “You cannot just focus on building the economy and talk about double-digit growth….An economic model which is built on denying democracy, denying people basic human rights, isn’t sustainable, and it will collapse.” Underlining her support for the collapse she is predicting, Ms. Mittal said: “If I am a foreign investor, I look for opportunities. I understand that there are risks, but in the face of this growing unrest where foreign companies have been targets, given all that has happened in terms of displacement of people and their lands given away to foreign investors, it would be astute to not go into a country like that.” Ms. Mittal’s comments are, of course, based on the Oakland Institute’s own failures of research as well as the seriously exaggerated stories emanating from Diaspora social media in the US. These, as even the Washington Post, normally highly critical of the Ethiopian government, was constrained to admit a couple of weeks ago, are “a bit hard to swallow”; the Post even referred to more and more dissident voices being heard over social media “but often without the restraint or commitment to accuracy of more mainstream media”. It quoted Prime Minister Hailemariam at the UN General Assembly: “We are seeing how misinformation could easily go viral via social media and mislead many people, especially the youth…Social media has certainly empowered populists and other extremists to exploit people’s genuine concerns and spread their message of hate and bigotry without any inhibition.”
As the Oakland Institute has shown in a number of reports it always accepts, totally uncritically, all Diaspora information as a norm in support of its contention that the promotion of large-scale industrial farming along with large-scale land seizures has been the key governmental strategy to drive development in Ethiopia. It argues that this is the central element in what it claims has been the total failure of development – the mirage, “manufacturing hunger and poverty in Ethiopia.” Its latest report says, “By 2011, the government had earmarked 3.6 million hectares for large-scale agriculture, and recently announced that 11.5 million hectares are available to investors.” This is a statistic repeated from earlier reports. In December 2014, Oakland Institute said: “in recent years, the Ethiopian government has leased over 3 million hectares to corporations for the development of large-scale agricultural plantations and is making available a total of 11.5 million hectares to investors.” In an earlier paper in 2011, “Understanding Land Investment Deals in Africa,” it said: “since early 2008, the Ethiopian Government has embarked on a process to award millions of hectares (ha) of land to foreign and national agricultural investors. Our research shows that at least 3,619,509 ha of land have been transferred, though the actual number may be higher.”
This is quite simply untrue. After an extensive investigation, done in 2014, of all relevant deals over the previous two decades, the Gates Foundation found the actual figures amounted to just about a million hectares leased. These came from the federal land bank – 380,000 hectares; regional government allocations – 335,000 hectares; and a further 335,000 hectares allocated for state-run sugar plantations. The Gates Foundation also pointed out these figures gave no indication of how much of this was actually in process of development. A great deal is not. The amount of land actually being used by large-scale investors is no more than a fraction of what the Oakland Institute, despite being corrected on a number of occasions, still persists in claiming is 3.6 million hectares.
This disparity, or rather this major error, on which much of Oakland Institute’s subsequent comments are based, must raise serious questions about the quality of Oakland Institute ‘research’ and the sources it employs. Similar questions arise out of other assertions that it persists in making. It claims, for example, in another repeated inaccuracy that the Gilgel Gibe III Dam, and the creation of sugar plantations in the Lower Omo River, could reduce the flow of the Omo River by as much as 70%, threatening the livelihoods of 200,000 Ethiopians and 300,000 Kenyans who depend on the water for herding, fishing, and flood-recession agriculture. The most recent studies of the Omo flow, ignored by the Oakland Institute, show that the amount of water needed for irrigation of the sugar plantations will only be extracted over three or four months each year, and will take out no more than 4%-6% of the river’s flow, and will have a minimal impact on Lake Turkana. In July this year, the World Heritage Committee concluded Ethiopia’s Kuraz Sugar Development Project neither endangered the Lower Omo Valley World Heritage Site nor compromised any environmental issues. As usual, the Oakland Institute’s ‘research’ ignores inconvenient facts like these. It prefers to quote problems that arose from the flawed attempts to set up sugar and cotton plantations in the Awash Valley in the Afar Region in the 1950s. Those projects did indeed drastically reduce land and water availability for people and livestock in the Awash Valley. But that was sixty years ago, and it has little bearing on the very different current development projects.
The central claim of the Oakland Institute is that the government is only interested in accelerating industrialization through large scale farming projects, through land grabs and driving indigenous groups off the land through its Commune Development or Resettlement Program. In order to support these allegations, it has to ignore the mass of publicly available information about all the programs that support, directly and indirectly, development of smallholder farmers. This is, in fact a core element of both the Growth and Transformation Plans 1 (2010/11-2014/5) and II (2015/16-2019/2020) as well as central element in the Government’s commitment to pro-poor spending, the progress achieved in poverty reduction and massive contributions to health, education and employment across the country. Over 70% of the federal budget is dedicated to pro-poor policies.
In fact, with its central aim of poverty reduction, much of Ethiopia’s growth strategy has been centered on the Agricultural Development-Led Industrialization program, focused on agriculture supplying commodities for export, domestic food supply and industrial output and expansion of the market for domestic manufactured goods. This has, of course, involved some support for large-scale commercial agricultural development, but it has also, necessarily and consistently involved major support for commercialization of smallholder agriculture, which makes up the far larger part of the country’s agricultural production. The ADLI operates through product diversification, a shift to value-added crops, promotion of high-value export crops and integration of local farm production with internal and external markets. A key element has been the deployment of agricultural extension workers, supported by an extensive TVET program, to every kebele in the country where they can provide support to smallholder farmers. Between 2004/05 and 2009/10, 61,785 agricultural extension agents were trained and 9,265 farmer-training centers were established. A very large part of the finance for this came from the Government, allowing it to ensure agricultural extension programs continued to be aimed at smallholder farmers.
Other pro-poor development programs have included the Sustainable Land Management Program (SLMP II), specifically aimed at reducing land degradation and increasing land productivity of smallholder farmers; and the Purchase for Progress (P4P) program to provide training for smallholder farmers in key techniques such as post-harvest handling, group marketing, agricultural finance and contracting; the Productive Safety Net Program (PSNP), the largest social protection program in Africa and a key driver of poverty reduction, targeting the most vulnerable areas and households in order to increase rural poor families’ long-term resilience to food shortages; and the Promotion of Basic Services (PBS) program, much of which specifically benefits smallholder agriculture with its continued decentralization of basic services, increasing completion of primary levels of education, lowering maternal mortality rates, increasing agricultural productivity, lowering the average time to reach all-weather roads, increasing access to potable water, increasing local government budget controls and audits controls, and increasing information flows to people in the woredas (districts). As the financial breakdown of the PBS demonstrates, education (62%), health (17%), and agriculture (18%) account for 97% of woreda spending. It is complemented by support for greater engagement among the people, improvements in local capacity to manage resources, and better access to information on national and local budgeting and development objectives. Increased woreda-level spending on agricultural extension workers is associated with higher yields for major crops, including cereals, vegetables, enset, coffee and fruit, and increases the probability that farmers, regardless of the size of their plots, will use improved farming techniques. The latest World Bank report noted the PBS was one of the few examples of a development program that has clearly quantifiable achievements. Indeed, not only does PBS meet its objectives, it has helped to make government spending more effective. The PBS has been described by those who know as “the most successful project of its kind in the world.”
All these pro-poor programs operate at local and regional state levels and thus place special emphasis on enhancing the productivity of smallholder farmers and pastoralists, strengthening market systems, improving participation of the private sector in agriculture, expanding the amount of land under irrigation and reducing the number of chronically food insecure households. They have achieved some impressive progress, an 8% or more growth rate for agriculture, the reduction of safety net program beneficiaries from 7.8 million to 1.8 million households, doubling production of major crops, and raising the emergency food reserve to 3 million tones. The delivery of public services across the country has allowed woredas, inter alia, to hire 100,000 additional primary school teachers, 38,000 health extension workers and 45,000 agricultural extension workers. It has helped people gain access to public budget information and provide basic budget literacy training for thousands. The proportion of people living below the poverty line has fallen steadily in the last few years, reducing to 22% last year. The Oakland Institute ignores all this, and equally disregards the fact that Ethiopia’s policies over the last decade or more have been specifically based on pro-poor and pro-development strategies, implemented though integrated planning, coordination, management and cooperation of government at federal, regional and local levels, aid agencies and the people. The fact that poverty reduction and food security have yet to be fully achieved does not render the policy a failure, whatever the Oakland Institute may think.
A good example of the way the Oakland Institute operates can be seen in its response to the Commune Development or Resettlement Program, instituted in 2003 for relevant areas of Afar, Gambella, Benishangul Gumuz, Southern Nations, Nationalities and Peoples, Somali, Amhara and Tigrai regional states. This is a program based on voluntary resettlement after full consultation; the use of under-utilized land; resettlement within the same regional state; and adequate preparation and provision of infrastructure and public services. The programs have achieved considerable level of success, and despite Oakland Institute claims of forced resettlement and widespread abuse, no independent investigations have found any serious failures or extensive abuse, though there have certainly been some minor hiccups.
The Oakland Institute, however, persists in claiming the World Bank, the IMF, UN agencies, EU agencies, the African Development Bank, the Donors Assistance Group, donor ambassadors and embassies in Ethiopia, NGOs working on the ground, and visitors to these areas, including Sir Malcolm Bruce, Chair of the UK Parliament’s Committee for International Development, and former US Ambassador, Donald Booth, either repeatedly and consistently lie, or deliberately refuse to see all the “numerous atrocities” that the Oakland Institute has seen from California. It dismisses out of hand all World Bank investigations and assessment missions, 34 investigations and evaluations of the PBS program by officials and experts of a dozen INGOs, assessments by representatives of the Governments of Austria, Spain, the Netherlands and others, Ethiopian federal, regional and local officials and others.
In its latest paper the Oakland Institute complains that the Ministry of Foreign Affairs has labeled it as anti-development. We have. It is a conclusion that is difficult to avoid when one considers the repeated efforts of the Institute to put a stop to the assistance provided by DfID, the World Bank and other partners to support the PBS and other highly successful pro-poor development programs aimed at improving smallholder agriculture. The Oakland Institute uses flawed methodology, unacceptable by any normal evidential research standards, built up from unverified and unverifiable information, with inaccurate and exaggerated accounts drawn from externally-based politically-motivated sources and seldom, if ever, checked on the ground. It ignores any criticisms of its reports. It refuses to accept any factual corrections. Indeed, despite a significant number of highly detailed and accurate refutations of its claims, it remains armored in its own “certainties”. It repeatedly criticizes the development programs that Ethiopia is trying to implement and even invents facts and figures to try to buttress its claims. In fact, it gives every indication of propagating a political agenda aiming to stop the contributions of the World Bank and other donors to Ethiopia’s pro-poor developmental programs and of supporting violent opposition to the government as well as contributing to the country’s destabilization. Indeed, in one of its recent report, the Institute specifically said, “Our hope is that this report will further pressure the US Congress and State Department to renegotiate the development assistance to Ethiopia.”


Posted by Richard A. Davey, MBTA General Manager
I am pleased to report that led by a big jump in customers on the subway lines, MBTA ridership in October reached its highest level in two years. October’s average weekday ridership topped 1.3 million for the first time since October 2008, and represents a 0.9% increase over October 2009.
The most significant ridership increase occurred on the Red, Orange, and Blue Lines, where October’s weekday ridership averaged 532,400, the highest level in four year for the T’s subway lines.
The Green Line’s average weekday ridership of 236,000 was the highest in more than a year.
Compared to 2009 when ridership fell every single month, the MBTA system has experienced growth in ridership this year in eight out of ten months.
I’ll be at Alewife Station tomorrow morning, Thursday December 2, from 7:00 a.m. to 9:00 a.m. for the next “Join the GM” session. I look forward to meeting with more MBTA customers and hearing what’s on their minds.
A First in the State: MassDOT Uses New Construction Technique on Route 2/I-95 Project posted on Aug 28
From smaller projects to the largest, MassDOT uses the latest, proven innovative techniques. For the first time in the state, MassDOT is using precast, modular concrete abutments on the Route 2/I-95 Bridge Replacement Project. Accelerated Bridge Construction technologies, such as this one, reduce project duration …Continue Reading A First in the State: MassDOT Uses New Construction Technique on Route 2/I-95 Project
Route 107 Corridor Public Meetings Scheduled posted on Aug 26
Public Information Meetings for the Route 107 Corridor Study have been scheduled as follows: Wednesday, September 7, 6:00 PM to 8:00 PM, Lynn English High School, Auditorium, 50 Goodridge Street Tuesday, September 13, 6:00 PM to 8:00 PM, Collins Middle School, Auditorium, 29 Highland Avenue, …Continue Reading Route 107 Corridor Public Meetings Scheduled
Gill-Montague Bridge Rehabilitation Celebrated posted on Aug 25
MassDOT Secretary and CEO Stephanie Pollack and Highway Administrator Thomas J. Tinlin joined Director of Governor Charlie Baker’s Western Massachusetts Office Michael Knapik, Senate President Stanley C. Rosenberg, state and local officials today in Turners Falls to celebrate the complete rehabilitation of the Avenue A …Continue Reading Gill-Montague Bridge Rehabilitation Celebrated


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Brighter The Moon
Brighter The Moon is an up and coming Virginia rock band. Inspired by the sounds of some of their favorite musicians such as Chris Carrabba (Dashboard Confessional), Andrew McMahon (SoCo, Jack's Mannequin), Brighter The Moon brings a unique sound focused on placing meaningful, heartfelt lyrics around driving melodies. With two EP's under their belt, Brighter The Moon has already shared the stage with many national touring acts such as New Politics, Morning Parade, Smallpools, The Dangerous Summer, RDGLDGRN, Rookie Of The Year, Transit, Hit The Lights, Sparks The Rescue and many more. The boys of Brighter The Moon have also been featured in XL102 Richmond's Rock Station's Artist in Residence Project. The guys are currently touring on their latest release, "In Search For Sound".
Deep Creek is a group of young talented high school musicians in northern Virginia who create their own music to share with the world. They are a rock band with roots and inspiration from classic rock legends such as Led Zeppelin, Rush, Pink Floyd, and Jimi Hendrix. Band members are also influenced by a wide range of backgrounds including blues, folk, jazz, and even a little reggae.

domain: entertainment


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Protests flared in Bangkok on Monday against the suspected kidnapping of a Thai activist in Cambodia which has reignited protests against Thailand’s military-royalist elite, with some online questioning a law banning criticism of the monarchy.
People hold signs in support of abducted Thai activist Wanchalearm Satsaksit during a protest calling for an investigation, in front of the Cambodian embassy in Bangkok, Thailand, June 8, 2020. REUTERS/Jorge Silva
Small student protests over the banning of a youth-oriented opposition party had bubbled up before the coronavirus pandemic, but were stopped by government restrictions during the health crisis.
Now anger is building again around Wanchalearm Satsaksit, 37, a previously little-known activist who fled Thailand following a 2014 coup.
Wanchalearm was abducted by unknown gunmen on Thursday in Cambodia’s capital, Phnom Penh, where he had lived to escape criminal charges for criticising the former Thai junta.
Dozens of protesters outside the Cambodian embassy in Bangkok demanded an investigation into the disappearance and accused the Thai state of orchestrating his kidnapping, which Thailand’s police and government have denied.
“I want the Thai government to protect people who are living abroad whether they are political exiles or not,” said protester Tattep Ruangprapaikitseree.
Thai Deputy Prime Minister Prawit Wongsuwan told reporters he had no information on the case but that Thailand would discuss it with Cambodian authorities.
“This case is their matter,” he said.
Cambodia’s government and police were not available for comment. They had previously denied knowledge of the incident.
At the weekend, posters labelled “Missing” appeared around Bangkok featuring photos of Wanchalearm and other critics of military governments who have disappeared in past decades.
The posters were the work of the Spring Movement, a small group of students at Bangkok’s elite Chulalongkorn University, group member Pun Thongsai told Reuters.
“After Wanchalearm disappeared, we wanted to do something beyond online,” said Pun, 26, a maths graduate. “We do not know who directly ordered the abduction, but we can see the ruling elite of this country does not care about this issue.”
In recent years, at least eight Thai activists who fled after a 2014 military coup have disappeared (here) from Laos, Cambodia or Vietnam, with the bodies of two of them later found floating in the Mekong River.
Wanchalearm was speaking on his mobile phone to his elder sister, Sitanun Satsaksit, on Thursday, she said.
The line was abruptly cut and after 20 minutes of frantic calls, she was told by a friend that her brother had been kidnapped from the street.
In a sign that the incident had stirred rare open questioning of the Thai monarchy as well as the government, the hashtag “#abolish112” trended on Thai-language Twitter, used or retweeted more than 450,000 times by midday on Monday.
It was an apparent reference to Article 112 of Thailand’s criminal code, which makes it illegal to insult the royal family and is punishable by up to 15 years in prison.
Any questioning of the monarchy’s sacrosanct position was once rare in the traditionalist Buddhist society.
Several of the missing dissidents had been accused of violating Article 112, but Thai officials denied that Wanchalearm faced lese majeste charges and his sister said he was not an anti-monarchist.
“The palace has no comment on this issue,” an official there said.

domain: law


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Adele's Lovesong cover of The Cure's Lovesong
Arctic Monkeys's Hold On, We're Going Home cover of Drake feat. Majid Jordan's Hold On, We're Going Home
Jimi Hendrix's All Along the Watchtower cover of Bob Dylan's All Along the Watchtower
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Five Finger Death Punch feat. Tech N9ne's Mama Said Knock You Out cover of LL Cool J's Mama Said Knock You Out
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Victoria Beckham ‘expanding at phenomenal rate’
Victoria Beckham has reportedly purchased a new convenience shop just around the corner from her current offices in South West London, as her fashion line is rapidly expanding.
The singer-turned-designer has four children with her football player husband David and her line is going from strength to strength.
Victoria and the family recently moved back to London from Los Angeles following the end of David’s contract with the Galaxy soccer team.
Now that she is back in the UK, Victoria has apparently purchased a property in which to open up shop in the neighbourhood of Battersea.
“Victoria’s range is going from strength to strength, and expanding at a phenomenal rate. Quite simply, she desperately needs more space,” a source explained to British newspaper The Mirror.
"She’s been looking at disused warehouses and shops for some time and heard the Spar newsagent around the corner had come on the market. Victoria is a canny businesswoman and has negotiated a great deal for herself.”
The convenience store will clearly require ample refurbishment before Victoria moves in.
"Whilst it’s not the most glamorous of operating spaces, it is functional and, once renovated, will provide a perfect base,” the insider said.
“Obviously she hasn’t bought it as her inaugural flagship store but she will be using it primarily as extra work space for her rapidly growing team.”
It has been reported Victoria has been a little lonely since she’s moved back to her native country.
Apparently it has been all work and little play.
"Victoria sometimes feels like, despite everything she's achieved over the years, she's failed somewhat because she doesn't have many friends. She's not settling into London well yet - it's all family and work. It's brought home the fact that some friendships have fallen by the wayside," an insider told the British edition of Closer magazine recently.
© Cover Media

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Types Of Btc Gambling
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Bitcoin Gambling Sites
Cryptocurrency gambling sites are a dime a dozen now that blockchain has swept into technology companies around the world. Online gambling sites should always provide clear descriptions of their fair play policies, even though every bitcoin dice game script should intrinsically be fair. This means that casinos should never be able to manipulate the outcomes of randomly generated rolls created by the user. The bitcoin casinos have many gambling and dice game which can be accessed by those who play. There is sports betting allowed with bitcoin. A fair sports betting site allows you to place bets on games like cricket. This is another simple bitcoin dice gambling site. Even though primedice is not much different from other dice platforms like duckdice and kingdice, it still offers an excellent gaming experience.
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Author: Charles Gillespie

domain: finance


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Pre-clinical studies with OP-101 have shown normalization of microglia, prevention of neuronal loss, and restoration of motor function. OP-101 is currently being evaluated for safety and pharmacokinetics in a healthy volunteer study in the United States (view on clinicaltrials.gov).
Summary of OP-101 Nonclinical Studies
- Efficacy demonstrated in animal models of human neonatal inflammation
- Maternal-fetal inflammation (rabbit-IV), Hypoxic-ischemia (mouse – IV), Necrotizing enterocolitis (mouse – oral)
- In all three models, OP-101 transitions reactive microglia from a pro-inflammatory state to a normal state
- Pharmacokinetics & clearance in mice and monkeys
- Completely cleared in 24 hr after IV dosing; 2-4 hr half-life
- SC dosing in monkeys results in slower absorption, lower Cmax, and more time on target than IV bolus
- OP-101 excreted intact in urine
- Bolus IV dosing in GLP tox studies limited to only dose dependent histological changes in rat kidneys
- NOAEL determined to be 200 mg/kg as single IV infusion
- Currently assessing potential for SC dosing to minimize potential Cmax effects on kidney clearance
OP-101 Mechanism of Action
OP-101 consists of N-acetyl cysteine (NAC) linked to a hydroxyl dendrimer via a disulfide bond. NAC prevents activation of the NF-κB pathway under oxidative and inflammatory stress conditions. NF-κB inhibition decreases expression of pro-inflammatory cytokines and chemokines (IL-6, IL-1β, TNFα, and CCL2).
NAC is approved by FDA for the treatment of treat paracetamol (acetaminophen) overdose and has demonstrated potent anti-oxidant properties. Orpheris is leveraging the drugs’ favorable safety profile and anti-inflammatory/anti-oxidant properties. By chemically linking NAC to the hydroxyl dendrimer dendrimer, we are able to avoid previous challenges of delivering NAC across the BBB to target neuroinflammation. Free-NAC is taken up by cells through the XCT transporter causing glutamate release (excitotoxicity). NAC also binds to plasma proteins and has limited BBB penetration. The pharmacology of NAC is altered to address these limitations by linking it to a hydroxyl dendrimer via a disulfide bond causing release primarily inside cells by intracellular glutathione (GSH). OP-101 selectively and efficiently delivers 20 NAC molecules per molecule of OP-101 inside reactive microglia returning the cells to their normal state (Navath 2008, 2010; Kurtoglu 2009; Wang 2009).
The differences in pharmacology and efficacy between OP-101 and NAC alone have been demonstrated in multiple animal models of neuroinflammation. For example, in a rabbit model of neonatal inflammation (similar to human chorioamnionitis), OP-101, but not NAC restores motor function after single dose (Kannan 2012). By restoring microglia to their normal state in this acute inflammation model, the rabbits are able to mature normally and return to normal function with no notable differences in function or histology from normal healthy controls at adulthood. The dramatic effect of OP-101 therapy in this model is illustrated in videos of treated and untreated rabbits (Download “supplemental video 2” – untreated; Download “supplemental video 3” – treated).
Recovery of Motor Function after a Single OP-101 Dose
Restoring Activated Microglia to Normal State with OP-101 (D-NAC)
First Indication: Childhood Cerebral Adrenoleukodystrophy (ccALD)
ccALD is a rare disease caused by the accumulation of very long chain fatty acids (VLCFA) and children with ALD present with severe neuroinflammation driven by activation of microglia (Eichler 2008; click here for more on ccALD).
While no preclinical model of the cerebral form of ALD exists, ex vivo studies with blood samples from ccALD patients have been tested to evaluate the effects of OP-101 and NAC alone. In a collaboration with Kennedy Krieger Institute, monocytes were isolated from the blood of normal volunteers, AMN (spinal form of ALD) and ccALD patients (n=4). Macrophages derived from the isolated monocytes were activated with the molar equivalent of VLCFA burden in ccALD – mimicking reactive microglia in patients. No effect of VLCFA stimulation was observed in macrophages from normal or AMN patients, as expected. In contrast, OP-101 restores ccALD specific macrophages – stimulated with VLCFA – to the normal state.

domain: medical


Car Temperature Gauge Goes Up And Down
The gauge showing your car’s temperature might be the most important in the vehicle. This gauge helps to prevent engine damage and warns you when it is overheating. You can pull your car over to let the engine cool off if the temperature goes up. What do you do if the temperature of your car goes up or down?
Temperature gauges can be affected by a poor thermostat or lack of coolant. It’s also possible that there is air in the cooling system. Alternately, it might be due to a deficient coolant temp sensor.
We will be discussing the issues that can lead to problems with temperature gauges in this guide. This guide will show you how to correct the problem as well as discuss the importance and benefits of diagnostics.
- What is the purpose of the car temperature gauge?
- The Car Temperature Gauge Changes Between Up and Down
- How to fix fluctuating temperature gauge
What is the purpose of the car temperature gauge?
The engine temperature can be viewed by the car temperature gauge. It’s normally located on the dashboard, near the speedometer. It’s designed to measure the coolant temperature, helping you see how hot or cold the motor is at any given time.
Coolant is circulated throughout the system by the water pump. It heats up when it's in an engine. Then, it’s cooled down when it gets to the radiator. To maintain the right temperature, the thermostat must stop or start the flow of coolant. There’s also a coolant temperature sensor found near the thermostat that sends the signal needed to create the gauge reading.
To determine whether the needle is in a good position, you must first know the engine's normal operating temperature. The gauge will be at the bottom when the engine is cool. The reading for most cars is at 122 degrees Fahrenheit.
The engine heats up once you start driving. The engine heats up and the heat transfers to the coolant. This regulates the temperature. It will display between 180 to 220 degrees Fahrenheit once the engine is warm and it is operating normally.
The coolant should stay at these temperatures until the engine is turned off. This is when the coolant ceases to flow and the temperature begins to drop.
The Car Temperature Gauge Changes Between Up and Down
1. Bad Thermostat
To regulate coolant temperature, the thermostat is installed. It can fail and cause the temperature gauge to fluctuate. If it starts to fail, the gauge will not respond in this manner.
When the thermostat is stuck closed, the coolant isn’t able to flow, so the engine won’t get cooled off. The motor heats up because of this.
Engine temperatures will drop to below the normal range if you leave your thermostat open. It is possible that you will have difficulty heating the HVAC system.
RELATED: 5 Signs that a Car Thermostat is Not Working
2. Low Coolant
Too much water can cause the temperature gauge to behave oddly. While some people mix water with the coolant, it’s important that too much doesn’t get into the system.
Temperatures will rise if there isn't enough coolant. Because water can’t adequately carry the heat away from the engine as coolant does, you could see unusual fluctuations in the temperature.
If the engine starts to overheat, it’s best to replace the coolant. Follow the recommended mixture of antifreeze and water based on your car’s service requirements.
Related: How low is the engine coolant level? (Causes & Consequences)
3. Air in Cooling System
Air could cause temperature drops in your system. A defective or broken head gasket can allow air to enter the system. You can also let air infiltrate the cooling system by leaking in the radiator hose, or doing improper coolant flush procedures.
If the coolant gets trapped in the air pocket, it can cause the engine to heat up. The engine can be re-started once it is moving.
4. Defective Temperature Gauge
It’s always possible that the temperature gauge itself is to blame. The instrument cluster isn’t the first thing to look at, but it always is a possibility if you can’t find anything else that’s wrong.
You will often see problems with other gauges when your instrument cluster has issues. Take a look at the other gauges to see if there’s an electrical fault.
RELATED: Temperature Gauge Stays On Cold? (Causes & How to Fix It)
5. Faulty Temperature Sensor
It’s more likely that the faulty readings are coming from a malfunctioning coolant temperature sensor (CTS). It is located in the engine, and can get contaminated.
The wrong signal could be sent if the sensor is damaged or corroded. If the sensor is not working properly, it can cause irregular readings.
6. Bad Computer Module
A bad module in the computer could cause your temperature gauge to behave erratically. It is necessary to relay data from other vehicles and engines.
It’s the module’s job to relay data that moves the temperature gauge. You may notice strange problems if your module goes bad. This part controls many other systems.
How to fix fluctuating temperature gauge
1. Thermostat should be replaced
You will pay $125 to $300 on average to get your thermostat changed. However, it’s not a difficult job to do yourself.
Find the thermostat first. The thermostat is likely located at the junction of the engine's top radiator hose and the bottom radiator hose. Take off the clamp, and place the coolant into a bucket.
Take out the thermostat, and replace it with a replacement gasket. Install the thermostat again, and then fill it with coolant.
2. Filter Cooling System
On average, a professional coolant flush costs between $65-$150. You can also do this job at home.
Fill the radiator with water. The vehicle should run for at least ten minutes. Then turn off the engine. Make sure to mix the appropriate amount of coolant in your system.
3. Bleed Cooling System
If you feel that air is getting stuck, it's possible to bleed your cooling system. You can remove the radiator cap. Fill it with as much coolant as you want. Turn the heat up to high and the fan on low.
Keep topping up the coolant until the levels fall. To circulate coolant, loosen the bleed valves. Keep doing this until your temperature does not fluctuate.
RELATED : How to Bleed Cars Cooling System (In 9 Simple Steps).
4. Change the temperature gauge sensor or gauge
Replacement of the temperature sensor cost should range from $200 to $450. You could need to change the coolant temperature sensor on the top or side of the engine, plus there’s a chance that the gauges themselves are to blame.
Before you replace parts, make sure to do proper diagnosis. Don't waste your money by doing unnecessary repairs.
5. Replace the Computer Module
The most expensive option of all repair options. The average cost of a new Engine Controller Module is between $300-$1,500, including labor and parts.
A good code scanner should reveal if there’s an issue with the Engine Control Module. As the central hub fails, you may notice additional unusual symptoms.
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The system to generate levels was going to be one of the more complex items to tackle for me and a cornerstone for the game as whole. Which is exactly why I put it off for a while and decided to start creating some nicer graphic assets which would be closer to the final product. As I mentioned in a previous post this kind of asset creation should probably be left for later while you’re still trying to get core functions of you game working, but here we are!
For all of my pixel art sprite work I use Asesprite. This was my first time using the software and I continue to be impressed by just how many features and options it had.
Using the rescaled elements from the prototype as a reference I created this new design for the Recon Rover. This lowfi pixel art style was much closer to what I originally had in mind compared to the vector assets seen previously. I knew this wouldn’t be the final version of the design but I was pretty happy with the vehicle shape and general style.
This wasn’t nearly as time consuming as I needed for this degree of procrastination so I started working on some of the different weapon types I’d been planning.
Those with a keen eye will notice these are broken up in to some different color highlights.
- Orange Beam Weapons
- Purple Rapid Fire Cannons
- Yellow Rail Guns
- Red Charge Beams
- Blue Wave Launchers
- Green Missile Launchers
The final item on the end is a cargo unit which would replace your turret for special challenge maps.
Recon Auth Signing Out

domain: hobby


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What is a Keto Diet ?
A keto meals are well known if you are a reduced carb diet, the spot that the body produces ketones within the liver to be utilized as energy. It's called many different names – ketogenic diet, reduced carb diet, low carbohydrate high fat (LCHF), etc. When you eat something an excellent source of carbs, your system will produce glucose and insulin. Glucose would be the easiest. Understanding the Keto Diet. The ketogenic meals are a lower carbohydrate, moderate protein, and fatty diet which puts one's body into a metabolic state generally known as ketosis. When you're person is in a state of ketosis, the liver produced ketones which get to be the main source of energy for the entire body. The ketogenic meals are also known as keto The ketogenic diet — better referred to as “keto” — is a bit of a moment today. It's been incredibly popular on social media marketing in recent weeks, and Google looks for keto-related terms have skyrocketed since new year; celebrities the kind of Tim Tebow and Kourtney Kardashian have touted it as a a.A keto weight loss program is a very low-carb diet, in which the body turns fat into ketones to use as energy. This increases weight loss, reduces hunger plus more. Learn how to consume a keto diet depending on real foods – things know about eat,
Ketogenic Diet Foods Allowed
Are you unclear what to eat using a keto diet? Here you can find a comprehensive food list and straightforward visual guides, showing you what things to eat and steer clear of on keto. For example, the very best and the worst keto vegetables, fruits, snacks, alcohol, fats & sauces etc. Not sure things to eat over a ketogenic diet? Here's a quick food list that you should reference. Below you can find a brief review of what you are able to eat. Scroll further as a result of see additional information on each section. Being over a diet isn't easiest thing in the entire world, specially when you don't know what you ought to eat. We've build this ...What can you eat for the keto diet? Learn the most effective and worst ketogenic foods to load on, including good choices like fish, eggs, poultry, meat, plus more. Plus, determine whether it is possible to eat commonly questioned foods including fruit and peanut butter! I understand it may be difficult to follow a healthy low-carb diet, specifically if you are not used to it.Printable Ketogenic Diet Food List I hope this comprehensive listing of keto-friendly foods will allow you to make the right choices. The KetoDiet approach is easy: It's about carrying out a low-carb diet the place that the focus is on eating real food, Are you trying to stick to a ketogenic diet yet not entirely sure what foods increase the risk for ketogenic diet food list? Find out the most effective high fat reduced carbohydrate foods. There are 108 ketogenic diet foods to prevent that will reduce (or banned) your fat burning capability. Ketogenic Diet Food Recipes The number of foods to prevent is extremely important within the ketogenic diet. Remember that carbs has to be kept small to remain in ketosis. Most people must stay within 20-30 grams of net carbs every day Jumping to the ketogenic diet and not using a rock-solid plan sets you up for failure . Use this approach, crafted by researchers and athletes who may have done the effort and made the switch already!
Ketogenic Mediterranean Diet Reviews
I evaluate the pros and cons in the Keto Diet and what I actually think of people while using ketogenic diet for weight reduction. I wasn't considering writing concerning the ketogenic diet but that most changed with my recent YouTube video. If you guys caught this video in my channel. However, many experts say ketosis itself is possibly not harmful. Some studies , actually, declare that a ketogenic weight loss program is safe for significantly overweight or obese people. However, other clinical reviews mention that patients on low- carbohydrate diets regain a selection of their lost weight inside of a year.increase which has a ketogenic diet. Harvard Health has discussing lipid particle size here before: -advanced-cholesterol-testing-. Although four years old now, that is a nice review with the literature on ketogenic diets many different health conditionsou can be hearing lots about the ketogenic diet so that you can slim down while noshing on butter and cream. This way of eating is suddenly hot among funding your company in Silicon Valley, who accept it will help them live longer and healthier, CNBC reports. Some praise the high-fat/ultra low-carb Ketogenic Diet Review. First of all, is there a Ketogenic Diet plan? The Ketogenic Diet plan is regarded a low carbohydrate and high fat diet. Often when compared to Atkins Diet along with other low carb diets available today Finding yourself confused with the seemingly endless promotion of weight-loss strategies and diet programs? In this series, we examine some popular diets— and assess the research to their rear. What is it? The ketogenic or “keto” dishes are a low-carbohydrate, fat-rich weight loss plan that has been used in centuries to help remedy
Many prefer doing a training that is finished with a mixture of body movements; just like the aerobic exercise while using cyclical ketogenic diet. It is not really an easy way to do as it requires a large amount of energy in performing it. This kind of exercise is not better to those who are over a restricted calorie diet particularly when their energy is additionally affected. When doing an aerobic fitness exercise you must have enough energy to achieve it so how will you able to accomplish it in case you are just eating a restricted amount of food. Once an individual is over a diet they may only do limited activities. It can even cause them to become easily get tired and become weak. This does not happen when you are over a ketogenic diet. It does not mean that when you're already on the diet you will also become healthy. Actually, oahu is the most affected in your life because you happen to be not eating enough food to give your body the nutrients that it needs. You may become slimmer however your health are usually in great danger. The only thing that can be done is to invest into dietary supplements that apart from losing weight it'll likewise provide your body with the nutrients which it requires. There are a lots of products that promises this type of benefits but most of it doesn't give your body the right amount of energy to do intense task. With the ketogenic diet you won't just achieve the perfect body which you wish to have but you will probably acquire huge amount of energy that you simply can use to do other job or the aerobic fitness exercise. Aerobic exercise with ketogenic weight loss program is the perfect combination that you simply can ever encounter because most of us wish to have a physically top fit and healthy body. W

domain: food


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OSF Saint Francis Recognized for Nursing Excellence
OSF HealthCare Saint Francis Medical Center has once again received Magnet Recognition for excellence in nursing. This latest designation means the Medical Center is one of only 58 health care organizations in the country to have received the honor four times in a row.
“Our fourth Magnet designation is confirmation of the outstanding care OSF Saint Francis nurses provide to our patients,” says Jennifer Hopwood, chief nursing officer. “Our nurses continue to exceed national benchmarks in quality and safety. This designation recognizes the actions we’ve taken to advance the profession of nursing through leadership, innovation, clinical excellence and research.”
Magnet Recognition from the American Nurses Credentialing Center is the highest and most prestigious distinction a health care organization can receive for nursing excellence and high-quality patient care. It’s earned by only 8 percent of U.S. hospitals.
Hospitals must reapply for the status every four years with each facility providing evidence of excellence and undergoing a site visit that verifies all documentation, nursing satisfaction and engagement. Hopwood notes that OSF Saint Francis invests in the re-designation because it keeps the hospital on a trajectory of excellence.

domain: news


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The U.S. Golf Association as announced the four-player team that will represent the United States in January at the Copa de las Americas. The co-ed team will include Lindy Duncan, Erynne Lee, Chris Williams and Steven Fox.
Williams and Fox were members of the U.S. team that recently won the World Amateur Team Championship in Antalya, Turkey. Williams, a senior at Washington, won the Mark H. McCormack Medal, awarded to the No. 1 player in the R&A World Amateur Golf Ranking. Fox is the reigning U.S. Amateur champion and a senior at Chattanooga.
Duncan, a senior at Duke, was a member of the U.S. Curtis Cup team. She was last year’s college Player of the Year. Lee, a sophomore at UCLA, represented the U.S. earlier this fall at the Women’s World Amateur Team Championship.
The Copa de las Americas is an amateur team competition for countries in North America, Central America, South America and the Caribbean. There are three 72-hole competitions – men’s, women’s and overall – with 18 holes played on each of the four days. Jim Williams of Orinda, Calif., will captain the Americans. He is a member of the USGA Executive Committee and a member of the USGA International Team Selection Committee.
“These four players are to be congratulated for being named to the USA Teams and for outstanding achievements throughout their careers,” said Williams. “They are undoubtedly up to this challenge, and I am honored to serve as their captain.”
Now in its fifth playing, the tournament will be played on U.S. soil for the first time in history. It takes place Jan. 3-6 at Doral Resort and Spa in Miami, Fla. The U.S. won in 2010, when the Copa de las Americas was played in Buenos Aires, Argentina.
Information from the USGA used in this report


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Women/Ladies/Teens Fighting For A Cure T-shirt
This T-shirt was made with a special touch, because it was made for a special cause. This shirt was made for cancer awareness. It was made for the woman who made a stand and decided to fight. This shirt was made for her, and for anyone else fighting for a cure.
The Cancer Awareness Fighting for a Cure t-shirt is a woman's shirt made of cotton and embellished with rhinestones. The form fitted women cut t-shirt would be a great gift to a cancer fighting woman to motivate her during her fight to beat cancer.
Rhinestones are well secured and do not wash off in laundry
Form fitting (order 1 size bigger for looser fit)

domain: design


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The Winter 2017 issue of the American Journal of Psychology is now online. Included as part of the journal’s continuing 130th anniversary coverage are articles on S. S. Stevens’s work on scaling and early work foreshadowing ecological psychology. A further article in the issue offers a digital history of authorship in the American Journal of Psychology and the Psychological Review. Full details below.
“S. S. Stevens’s Invariant Legacy: Scale Types and the Power Law,” by Lawrence M. Ward. Abstract:
S. S. Stevens was one of a number of prominent psychologists who published seminal articles in The American Journal of Psychology (AJP). Indeed, the first or, arguably, most important articles in several of his research strands were published there. In this brief treatment of his monumental work, I review these articles and some of their sequelae, both in Stevens’s own work and in that of others, in an attempt to sketch out how Stevens’s contributions in AJP helped form the development of experimental sensory and perceptual psychology throughout the 20th century. I focus on his work in psychophysical scaling, because in my opinion that has been his most important legacy. Indeed, the article that probably generated the flurry of work in psychophysical scaling that persisted into the 1990s was a brilliant work published in 1956 in AJP. In that article Stevens not only demonstrated the validity and reliability of direct scaling (in this case magnitude estimation and production) but also investigated a range of factors that could affect its results, anchoring the later work that led to its adoption as the fundamental and most popular approach to psychophysical scaling still in use today. In this section I also expand on a few of the modern directions in which this work has gone. Stevens also published in AJP classic articles on the localization of sound, the dimensions of sound, the relation of volume to intensity, and the neural quantum in pitch and loudness discrimination. He even contributed an article on scaling coffee odor. His work is a stellar example of how AJP has influenced psychological science then and now.
What is the relationship between being highly prolific in the realm of publication and being remembered as a great psychologist of the past? In this study, the PsycINFO database was used to identify the historical figures who wrote the most journal articles during the half-century from 1890 to 1939. Although a number of the 10 most prolific authors are widely remembered for their influence on the discipline today—E. L. Thorndike, Karl Pearson, E. B. Titchener, Henri Piéron—the majority are mostly forgotten. The data were also separated into the 5 distinct decades. Once again, a mixture of eminent and obscure individuals made appearances. Most striking, perhaps, was the great increase in articles published over the course of the half-century—approximately doubling each decade—and the enormous turnover in who was most prolific, decade over decade. In total, 100 distinct individuals appeared across just 5 lists of about 25 names each.
A new national project, After the Asylum/Après l’asile, documenting the shift from institutional care to community mental health in Canada has recently launched. As historians Megan Davies and Erika Dyck discuss in a recent blog post,
The shift from institutional to community mental health was among the most significant social changes of the late 20th century. Between 1965 and 1980 nearly 50,000 beds were closed in residential psychiatric facilities across Canada. De-institutionalization profoundly changed the lives of former patients and those who worked with them, impacting the larger economy, public health and social planning, and challenging ideas of individual rights and capabilities.
The first national project of its kind, After the Asylum/Après l’asilepresents this complex and often difficult history, making clear its continuing relevance. We examine early mental health initiatives, we consider how therapeutic and professional contours of care were reshaped, and we explore new consumer / user networks and cultures that emerged. Many of the exhibits speak to the continuing social and economic marginalization of people deemed mentally ill, whose lives are often poignant testaments to the limits of a reconstituted mental health system.
Stephanie Kingsley (over on the American Historical Association‘s blog) put up a post on the ethical and technical challenges of retaining records of the web. Summarizing the proceedings of a day symposium on the topic, Kingsley also consults with the York Psyborg lab’s good fried Ian Milligan (Waterloo) to expound on the complex topic. She also provides a compendium of resources for those historians interested in contributing to projects being undertaken to #SaveTheWeb. Find the full post here.
This interactive timeline offers the reader a brief guide to this longer history. I define replication fairly broadly, but attempt to not simply offer a history of psychology in its entirety. Instead, I have focused on famous replication controversies from the past alongside the development of psychology’s favored research methods.
I am personally quite agnostic as to the value of the current interest in direct replication. My worry is that it distracts (as is often the case in psychology) from questions of external validity. My goal is to provide a richer context for contemporary controversies animating psychology.
I welcome corrections, updates, and suggestions of relevant topics. Please contact me at mpettit at yorku.ca
Phoebe Harkins, the Library Communications Co-ordinator at Wellcome, has posted an application announcement for a new contractual position of Wikimedian in Residence on their blog (flexible 6-12 months, depending on the projects the Wikimedian proposes and develops).
Excerpts from the post:
Incurably curious? Interested in the history of medicine? Know a bit about Wikipedia?
Our collections cover so much more than the history of medicine – essentially life, death and everything in between, so there’s huge potential for improving the content on Wikipedia. We’ll also be looking at enriching other Wikimedia projects.
The Wikimedian will work with us on the project to help develop areas of Wikipedia covered by our amazing holdings. We’d love you to help us to make our world-renowned collections, knowledge and expertise here at the Wellcome Library even more accessible.
Looking for a little bit of nerdy entertainment before diving into the winter work season? Well you’ve come to the right place! Amuse yourself and assist the research of Dr. Christopher Green out of York’s Psyborgs Lab at the same time by playing Psychology’s Elorater.
It’s easy and addictive: simply rate the greater impact on psychology between pairs of psychologists (click here), or learn a bunch exploring the full profiles (click here); also check out the current ranking lists (click here)!
The American Journal of Psychology (AJP) was the first academic journal in the united states dedicated to the “new” scientific form of the discipline. But where did the journal’s founding owner/editor, G. Stanley Hall, find the “psychologists” he needed to fill the pages of such a venture 1887, when he was still virtually the only professor of psychology in the country? To investigate this question we used the substantive vocabularies of every full article published in AJP’s first 14 volumes to generate networks of verbally similar articles. These networks reveal the variety of research communities that hall drew on to launch and support the journal. three separate networks, corresponding to 3 successive time blocks, show how hall’s constellation of participating research communities changed over AJP’s first 17 years. Many of these communities started with rather nebulous boundaries but soon began to differentiate into groups of more distinct specialties. some topics declined over time, but new ones regularly appeared to replace them. We sketch a quasievolutionary model to describe the intellectual ecology of AJP’s early years.
AHP is pleased to announce the launch of a rich new web resource: the Museu de História das Neurociências Comportamentais [the History Museum of Behavioral Neuroscience]. The site features a digital collection of scientific instruments connected to the history of neuroscience, particularly behavioral neuroscience, in Brazil. It likewise highlights several key researchers who contributed to the development of behavioral neuroscience in Brazil.
The Museu de História das Neurociências Comportamentais will be of particular interest to those interested in scientific instrument collections and will make for a great online resource for both historians of psychology and their students alike. If your Portuguese is on the weak side, do not despair! You can use your browser settings to translate the pages to your language of choice (Google Chrome makes this particularly easy – see instructions here).
The Museu de História das Neurociências Comportamentais has plans to continue growing and contributions to the site are welcomed. To submit a photograph of an instrument, laboratory space, or researcher connected to the history of behavioral neuroscience in Brazil, contact firstname.lastname@example.org with a description of the person or object featured in the image, the name of the institution to which it is connected, and any references or links you would want included with the entry (You can download the contribution form here).
The May 2015 issue of History of Psychology (vol 18, issue 2) is now available (find online here), and is chock-full of interesting content. From analyses exploring the materiality of psychological and psychiatric instruments (including the Cattell Infant Intelligence Scale, the ‘Utica Crib,’ and the controversial transorbital ice pick lobotomy instrument introduced by Walter Freeman), to historiographic discussions (about how to further internationalize the practice of the history of psychology in North America, and about the necessity of attention to multiple temporalities and contexts within the history of psychology in Brazil), there’s a little something for everyone.
The abstracts read as follows:
Test or toy? Materiality and the measurement of infant intelligence.
By: Young, Jacy L.
Adopting a material culture perspective, this article interrogates the composition of the copy of the Cattell Infant Intelligence Scale housed at the University of Toronto Scientific Instruments Collection. As a deliberately assembled collection of toys, the Cattell Scale makes clear the indefinite boundary between test and toy in 20th-century American psychology. Consideration of the current condition of some of the material constituents of this particular Cattell Scale provides valuable insight into some of the elusive practices of intelligence testers in situ and highlights the dynamic nature of the testing process. At the same time, attending to the materiality of this intelligence test reveals some of the more general assumptions about the nature of intelligence inherent in tests for young children. The scale and others like it, I argue, exposes psychologists’ often-uncritical equation of childhood intelligence with appropriate play undertaken with an appropriate toy, an approach complicit in, and fostered by, midcentury efforts to cultivate particular forms of selfhood. This analysis serves as an example of the kind of work that may be done on the history of intelligence testing when the material objects that were (and are) inherently a part of the testing process are included in historical scholarship.

domain: library


Talking from Elton John’s Oscar-viewing party (alright for some: we just watched the ceremony in our lounge with an industrial-sized vat of tea), he spoke about the technical process involved in playing a dragon, and his relationship with the cast and crew.
On his Hobbit experience, Sherlock star Cumberbatch said, “I was very lucky [ to work ] with Pete [ Jackson ].”
“As far as the experience, what an extraordinary one it was because at the time I was in my work, I was in isolation with him and this incredible tag team. And at the very cool place with that technology doing mo-cap for two characters, Smaug the dragon and another character, which will remain nameless, and it was an awful lot of fun.”
“It’s a sort of wonderful ongoing process,” he added. “I spent a lot of time recording voice as well as doing movements. So, it was sort of freeing; it was fun. It was like playing a game.
“It’s going to be an amazing film; it’s going to be a real treat. I watched The Lord Of The Rings again before I started working, and the way those films grow in depth of craft on every level are extraordinary. Their mark is for that.”
And on working with his Sherlock co-star Martin Freeman (who plays Bilbo), Cumberbatch said: “It was great. I got to hang out with him, and I kept a straight face for a bit and then I started giggling because I know Martin, I don’t know Bilbo.
“For Martin to be sitting there playing Bilbo is amazing. He’s going to be amazing, he’s going to be fantastic in this film.”
The Hobbit: An Unexpected Journey opens on 14 December 2012. We’re possibly even more excited about it than Cumberbatch is.


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Return of The Orange Squirrel One Night Only
6:30 PM - 10:00 PM Saturday, May 4
An accomplished and visionary chef, Chef Francesco spent eight years working at top New York City restaurants and owned and operated his own acclaimed restaurant, The Orange Squirrel, in his hometown of Bloomfield, New Jersey for eight years.
Chef Francesco’s culinary interest was sparked at an early age by his mother’s Italian home cooking that was prepared with organic vegetables grown in their garden. This started the path to his education at Culinary Institute of America (CIA), which included a culinary externship in Frankfurt, Germany. Upon graduating CIA in 2000, Chef Francesco’s first foray into the culinary field began at the world-renowned Windows on the World restaurant in the World Trade Center in New York City where he trained with his mentor, Chef Michael Lomonaco for two years until the tragic events of 9/11.
Immediately following Windows on the World, Palmieri joined Pino Luongo’s team at Coco Pazzo as Sous Chef where he honed his skills under Chef Marta Pulini. During his two years at Coco Pazzo he cooked for a host of celebrities and notable clientele and finished as acting Executive Chef. He then spent three years as Sous Chef with Iron Chef Geoffrey Zakarian at Town, a Three Star restaurant.
At The Orange Squirrel, his innovative culinary style is reflected in the contemporary American upscale comfort cuisine with European accents made with premium, fresh ingredients that include house-made pastas; ‘couture’ pizzas and a selection of main entrees with an extensive assortment of side dishes. A multi-creative talent, Chef Francesco also attended the Fashion Institute of Technology for Interior Design, which proved beneficial as he personally designed and hand-crafted The Orange Squirrel. His inspiration for the décor was a modern, art deco style featuring a one-of-a-kind Wood Stone oven, a custom made “floating” Brazilian birch and limestone bar, and imported Italian furniture and lighting.
He is married to Elaine, a make-up artist and currently lives in his hometown of Bloomfield, NJ. A 21st century Renaissance man, he is passionate about applying his creativity in all his artistic endeavors.