anthonyyazdaniml/gliner-biomed-pre-training

tokenized_text listlengths 6 2.61k	ner listlengths 0 194
[ "People", "with", "moderate", "to", "severe", "chronic", "obstructive", "pulmonary", "disease", "(", "COPD", ")", "experience", "intense", "symptoms", "of", "dyspnea", "when", "they", "use", "their", "arms", "and", "shoulders", ".", "To", "control", "dyspnea", ...	[ [ 2, 11, "Condition" ], [ 16, 16, "Symptom" ], [ 27, 27, "Symptom" ], [ 212, 212, "Symptom" ], [ 21, 23, "Body parts" ], [ 40, 45, "Physical attribute" ], [ 53, 54, "Activity level" ], [ 57, 59, ...
[ "Carcinogenesis", "The", "carcinogenic", "potential", "of", "orally", "administered", "frovatriptan", "was", "evaluated", "in", "an", "84", "-", "week", "study", "in", "mice", "(", "4", ",", "13", ",", "and", "40", "mg", "/", "kg", "/", "day", ")", ",", ...	[ [ 7, 7, "Drug" ], [ 268, 268, "Drug" ], [ 294, 294, "Drug" ], [ 306, 306, "Drug" ], [ 338, 338, "Drug" ], [ 17, 17, "Animal model" ], [ 63, 63, "Animal model" ], [ 38, 38, "Animal model" ], ...
[ "BACKGROUND", ":", "Calcium", "(", "Ca", ")", "is", "a", "nutritional", "factor", "that", "associated", "with", "dental", "caries", ".", "A", "recent", "study", "showed", "that", "in", "the", "case", "of", "adequate", "Ca", "intake", ",", "a", "higher", ...	[ [ 2, 5, "Nutritional factor" ], [ 13, 14, "Disease" ], [ 70, 71, "Disease" ], [ 142, 143, "Disease" ], [ 190, 191, "Disease" ], [ 208, 209, "Disease" ], [ 296, 297, "Disease" ], [ 403, 404, "D...
[ "The", "present", "invention", "relates", "to", "a", "traditional", "Chinese", "medicine", "for", "treating", "hypertension", "emergency", ",", "which", "is", "derived", "from", "a", "clinical", "empirical", "prescription", ".", "The", "traditional", "Chinese", "m...	[ [ 11, 12, "Condition" ], [ 128, 129, "Condition" ], [ 323, 324, "Condition" ], [ 6, 8, "Treatment" ], [ 24, 26, "Treatment" ], [ 35, 36, "Ingredient" ], [ 43, 45, "Ingredient" ], [ 52, 53, "In...
[ "Hypercholesterolemia", "(", "Heterozygous", "Familial", "and", "Nonfamilial", ")", "and", "Mixed", "Dyslipidemia", "(", "Fredrickson", "Types", "IIa", "and", "IIb", ")", "\n\n", "The", "effects", "of", "fenofibrate", "at", "a", "dose", "equivalent", "to", "200"...	[ [ 0, 0, "Condition" ], [ 2, 3, "Subtype" ], [ 5, 5, "Subtype" ], [ 8, 9, "Condition" ], [ 11, 15, "Subtype" ], [ 21, 21, "Drug" ], [ 29, 29, "Drug" ], [ 90, 90, "Drug" ], [ 112, 11...
[ "In", "2018", ",", "rTMS", "received", "approval", "from", "the", "U.S.", "Food", "and", "Drug", "Administration", "(", "FDA", ")", "for", "the", "treatment", "of", "OCD", ".", "Based", "on", "randomized", "clinical", "trials", ",", "researchers", "have", ...	[ [ 3, 3, "Treatment" ], [ 174, 174, "Treatment" ], [ 249, 249, "Treatment" ], [ 275, 275, "Treatment" ], [ 8, 15, "Organization" ], [ 1, 1, "Year" ], [ 20, 20, "Condition" ], [ 73, 73, "Conditi...
[ "In", "active", "tACS", ",", "the", "target", "'", "active", "'", "electrode", "was", "placed", "over", "the", "MFC", "and", "the", "second", "'", "return", "'", "electrode", "was", "placed", "over", "the", "medial", "parietal", "cortex", ".", "6", "Hz",...	[ [ 1, 2, "Medical procedure" ], [ 5, 9, "Device" ], [ 14, 14, "Anatomical structure" ], [ 17, 21, "Device" ], [ 26, 28, "Anatomical structure" ], [ 30, 32, "Stimulation frequency" ], [ 37, 38, "Stimulation typ...
[ "Wilson", "'s", "disease", "(", "hepatolenticular", "degeneration", ")", "occurs", "in", "individuals", "who", "have", "inherited", "an", "autosomal", "recessive", "defect", "that", "leads", "to", "an", "accumulation", "of", "copper", "far", "in", "excess", "of"...	[ [ 0, 2, "Disease" ], [ 115, 117, "Disease" ], [ 4, 5, "Synonym" ], [ 14, 16, "Genetic condition" ], [ 23, 23, "Substance" ], [ 33, 33, "Substance" ], [ 69, 69, "Substance" ], [ 175, 175, "Subs...
[ "Microglia", ",", "the", "resident", "immune", "cells", "of", "the", "central", "nervous", "system", "(", "CNS", ")", ",", "have", "received", "significant", "attention", "due", "to", "their", "critical", "roles", "in", "maintaining", "brain", "homeostasis", "...	[ [ 0, 0, "Cell type" ], [ 38, 38, "Cell type" ], [ 52, 52, "Cell type" ], [ 67, 67, "Cell type" ], [ 109, 109, "Cell type" ], [ 159, 159, "Cell type" ], [ 177, 177, "Cell type" ], [ 188, 188, "...
[ "Effective", "exudate", "management", "is", "key", "for", "optimal", "ulcer", "healing", ".", "Superabsorbent", "dressings", "are", "designed", "to", "have", "high", "fluid", "handling", "capacity", ",", "reduced", "risk", "of", "exudate", "leakage", ",", "fluid...	[ [ 0, 2, "Concept" ], [ 7, 8, "Outcome" ], [ 10, 11, "Intervention" ], [ 56, 57, "Intervention" ], [ 199, 200, "Intervention" ], [ 211, 212, "Intervention" ], [ 269, 270, "Intervention" ], [ 16, 19...
[ "The", "purpose", "of", "this", "study", "is", "to", "pilot", "test", "a", "newly", "developed", "strengths", "-", "based", "clinical", "intervention", "delivered", "by", "diabetes", "care", "providers", "in", "the", "context", "of", "routine", "ambulatory", "...	[ [ 4, 4, "Research study" ], [ 16, 16, "Clinical intervention" ], [ 53, 53, "Clinical intervention" ], [ 100, 100, "Clinical intervention" ], [ 110, 110, "Clinical intervention" ], [ 177, 177, "Clinical intervention" ], [...
[ "Subjects", "will", "receive", "EnteraGam", "®", "(", "oral", "nutritional", "therapy", ")", "+", "standard", "of", "care", "for", "COVID-19", "for", "2", "weeks", ".", "Total", "study", "duration", "(", "including", "the", "screening", "phase", ")", "will",...	[ [ 3, 4, "Drug" ], [ 6, 8, "Treatment" ], [ 11, 15, "Treatment" ], [ 17, 18, "Duration" ], [ 32, 33, "Duration" ] ]
[ "The", "Device", "has", "the", "promise", "of", "providing", "a", "novel", "mechanism", "for", "reducing", "or", "preventing", "the", "likelihood", "of", "TBI", ",", "and", "may", "be", "used", "in", "conjunction", "with", "other", "protective", "equipment", ...	[ [ 1, 1, "Intervention" ], [ 120, 120, "Intervention" ], [ 437, 437, "Intervention" ], [ 456, 456, "Intervention" ], [ 493, 493, "Intervention" ], [ 510, 510, "Intervention" ], [ 536, 536, "Intervention" ], ...
[ "Cisplatin", "injection", "is", "a", "highly", "emetogenic", "antineoplastic", "agent", ".", "Premedicate", "with", "anti", "-", "emetic", "agents", "[", "see", "Dosage", "and", "Administration", "(", "2.1", ")", "]", ".", "Without", "antiemetic", "therapy", "...	[ [ 0, 1, "Drug" ], [ 40, 41, "Drug" ], [ 129, 130, "Drug" ], [ 6, 7, "Drug class" ], [ 11, 14, "Drug class" ], [ 17, 19, "Section" ], [ 30, 32, "Adverse drug event" ], [ 54, 56, "Adverse drug e...
[ "Group", "1", ":", "25", "healthy", "lean", "men", "(", "age", "30", "-", "45", ",", "BMI", "\\<28", ")", "with", "genetic", "predisposition", "for", "type", "2", "diabetes", "mellitus", "(", "T2DM", ")", "-", "i.e.", "their", "two", "first", "-", "d...	[ [ 0, 1, "Study group" ], [ 3, 6, "Participant characteristics" ], [ 8, 11, "Age range" ], [ 17, 66, "Inclusion criteria" ], [ 71, 92, "Exclusion criteria" ] ]
[ "Type", "2", "diabetes", "mellitus", "is", "regarded", "as", "one", "of", "the", "most", "prevalent", "disease", "of", "the", "adult", "population", ".", "In", "many", "developing", "countries", ",", "this", "condition", "is", "regarded", "as", "major", "pub...	[ [ 0, 3, "Disease" ], [ 15, 16, "Population group" ], [ 20, 21, "Location" ], [ 29, 31, "Health issue" ], [ 38, 39, "Condition" ], [ 42, 44, "Symptom" ], [ 50, 51, "Condition" ], [ 54, 55, "Con...
[ "Although", "endovascular", "treatment", "(", "EVT", ")", "has", "developed", "and", "still", "progressing", ",", "calcified", "lesions", "remain", "a", "big", "challenge", "to", "operators", "in", "obtaining", "good", "results", ".", "Whenever", ",", "the", "...	[ [ 1, 5, "Medical procedure" ], [ 12, 13, "Medical condition" ], [ 28, 33, "Medical condition" ], [ 37, 38, "Medical procedure" ], [ 43, 44, "Medical condition" ], [ 52, 57, "Patient" ], [ 60, 65, "Medical con...
[ "The", "invention", "discloses", "a", "traditional", "Chinese", "medicine", "composition", "for", "treating", "cold", "-", "dampness", "blockage", "type", "calcaneodynia", "and", "a", "preparation", "method", "thereof", ".", "The", "traditional", "Chinese", "medicin...	[ [ 4, 7, "Drug" ], [ 23, 26, "Drug" ], [ 195, 198, "Drug" ], [ 10, 15, "Condition" ], [ 203, 208, "Condition" ], [ 222, 227, "Condition" ], [ 42, 52, "Ingredient" ], [ 59, 60, "Ingredient" ],...
[ "PURPOSE", ":", "The", "objective", "of", "this", "retrospective", "cohort", "study", "was", "to", "investigate", "the", "predictive", "value", "of", "stress", "-", "induced", "hyperglycemia", "parameters", "for", "delayed", "healing", "after", "tibial", "fracture...	[ [ 16, 20, "Medical term" ], [ 70, 74, "Medical term" ], [ 167, 171, "Medical term" ], [ 221, 225, "Medical term" ], [ 246, 250, "Medical term" ], [ 287, 291, "Medical term" ], [ 22, 23, "Medical condition" ...
[ "Keloid", "scars", ",", "characterized", "by", "abnormal", "fibroproliferation", "and", "excessive", "extracellular", "matrix", "(", "ECM", ")", "production", "that", "extends", "beyond", "the", "original", "wound", ",", "often", "cause", "pruritus", ",", "pain", ...	[ [ 0, 1, "Condition" ], [ 204, 205, "Condition" ], [ 5, 6, "Pathological process" ], [ 8, 14, "Pathological process" ], [ 24, 24, "Symptom" ], [ 26, 26, "Symptom" ], [ 29, 29, "Symptom" ], [ 34, 36...
[ "BACKGROUND", ":", "A", "care", "bundle", "comprises", "a", "set", "of", "evidence", "-", "based", "practices", "in", "patient", "care", "that", "are", "grouped", "together", "with", "the", "assumption", "that", "these", "practices", "when", "performed", "toge...	[ [ 3, 4, "Medical intervention" ], [ 244, 245, "Medical intervention" ], [ 9, 12, "Medical practices" ], [ 14, 15, "Medical care" ], [ 33, 34, "Medical outcomes" ], [ 46, 46, "Medical devices" ], [ 56, 59, "In...
[ "Methadone", "Hydrochloride", "Oral", "Concentrate", ",", "USP", "dye", "-", "free", ",", "sugar", "-", "free", ",", "unflavored", "contains", "methadone", ",", "an", "opioid", "agonist", ",", "and", "is", "available", "as", "a", "dye", "-", "free", ",", ...	[ [ 0, 5, "Drug product" ], [ 0, 0, "Active pharmaceutical ingredient" ], [ 16, 16, "Active pharmaceutical ingredient" ], [ 39, 39, "Active pharmaceutical ingredient" ], [ 46, 46, "Active pharmaceutical ingredient" ], [ 59, 59, ...
[ "INTRODUCTION", ":", "Pisa", "syndrome", "(", "PS", ")", "is", "a", "postural", "abnormality", "that", "frequently", "manifests", "in", "various", "neurological", "disorders", ".", "In", "recent", "years", ",", "the", "dangers", "associated", "with", "Parkinson"...	[ [ 2, 6, "Condition" ], [ 27, 32, "Condition" ], [ 80, 80, "Treatment" ], [ 95, 95, "Treatment" ], [ 117, 117, "Treatment" ], [ 172, 172, "Treatment" ], [ 192, 192, "Treatment" ], [ 205, 205, "...
[ "Immunogenic", "compositions", "and", "methods", "for", "eliciting", "an", "immune", "response", "against", "S.", "epiderrnidis", "and", "other", "related", "staphylococci", "are", "provided", ".", "The", "immunogenic", "compositions", "can", "include", "immunogenic",...	[ [ 0, 1, "Composition" ], [ 20, 21, "Composition" ], [ 7, 8, "Biological process" ], [ 54, 55, "Biological process" ], [ 10, 11, "Pathogen" ], [ 15, 15, "Pathogen" ], [ 41, 41, "Pathogen" ], [ 62, ...
[ "There", "is", "a", "current", "need", "to", "develop", "a", "split", "-", "dose", "cisplatinum", "regimen", "in", "combination", "with", "pemetrexed", "with", "high", "efficacy", ",", "excellent", "treatment", "compliance", ",", "administration", "convenience", ...	[ [ 11, 12, "Treatment protocol" ], [ 16, 16, "Chemotherapy drug" ], [ 18, 19, "Outcome measure" ], [ 21, 23, "Outcome measure" ], [ 25, 26, "Outcome measure" ], [ 34, 35, "Treatment setting" ], [ 45, 53, "Dosa...
[ "Treatment", "with", "placebo", "combined", "with", "vedolizumab", ";", "Subjects", "will", "receive", "two", "sachets", "daily", "of", "Placebo", "for", "14", "weeks", ".", "Vedolizumab", "will", "be", "administere", "as", "per", "clinical", "practice", "with",...	[ [ 2, 2, "Drug" ], [ 14, 14, "Drug" ], [ 5, 5, "Drug" ], [ 19, 19, "Drug" ], [ 11, 11, "Dosage form" ], [ 12, 12, "Frequency" ], [ 16, 17, "Duration" ], [ 42, 43, "Duration" ], [ 25, ...
[ "Aims", ":", "Seawater", "immersion", "significantly", "aggravated", "organ", "dysfunction", "following", "hemorrhagic", "shock", ",", "leading", "to", "higher", "mortality", "rate", ".", "However", ",", "the", "effective", "treatment", "is", "still", "unavailable",...	[ [ 2, 3, "Condition" ], [ 51, 52, "Condition" ], [ 73, 74, "Condition" ], [ 110, 111, "Condition" ], [ 232, 233, "Condition" ], [ 253, 254, "Condition" ], [ 9, 10, "Condition" ], [ 55, 56, "Con...
[ "FIELD", ":", "medicine", ".", "SUBSTANCE", ":", "invention", "relates", "to", "the", "development", "of", "drugs", "of", "natural", "origin", "showing", "the", "broad", "spectrum", "of", "pharmacological", "effect", ".", "Invention", "proposes", "two", "agents"...	[ [ 2, 2, "Field of study" ], [ 12, 15, "Substance" ], [ 21, 22, "Effect" ], [ 26, 27, "Substance" ], [ 33, 33, "Substance" ], [ 97, 97, "Substance" ], [ 39, 40, "Substance" ], [ 47, 48, "Substa...
[ "This", "trial", "is", "open", "-", "label", ",", "prospective", "intervention", "study", ".", "A", "total", "of", "150", "subjects", "who", "had", "previously", "received", "complete", "primary", "doses", "of", "IndoVac", "®", "in", "phase", "III", "and", ...	[ [ 24, 25, "Vaccine" ], [ 27, 28, "Clinical trial phase" ], [ 14, 15, "Sample size" ], [ 40, 41, "Document" ], [ 55, 56, "Dosage" ], [ 60, 62, "Vaccine administration" ], [ 70, 70, "Outcome measure" ], [ ...
[ "Immunosuppressed", "patients", "are", "at", "increased", "risk", "for", "opportunistic", "infections", ",", "including", "activation", "of", "latent", "viral", "infections", ".", "These", "include", "BK", "virus", "-", "associated", "nephropathy", ",", "which", "...	[ [ 0, 1, "Patient group" ], [ 153, 154, "Patient group" ], [ 7, 8, "Condition" ], [ 13, 15, "Condition" ], [ 19, 23, "Condition" ], [ 74, 78, "Condition" ], [ 92, 96, "Condition" ], [ 30, 32, "...
[ "Neuromyelitis", "optica", "spectrum", "disorder", "(", "NMOSD", ")", "is", "a", "severe", "form", "of", "inflammation", "of", "the", "central", "nervous", "system", "(", "CNS", ")", "including", "acute", "myelitis", ",", "optic", "neuritis", "and", "brain", ...	[ [ 0, 6, "Disease" ], [ 15, 20, "Anatomical structure" ], [ 22, 23, "Symptom" ], [ 25, 26, "Symptom" ], [ 28, 29, "Symptom" ], [ 39, 40, "Diagnostic test" ], [ 47, 54, "Serological marker" ], [ 75, ...
[ "The", "study", "design", "includes", "an", "age-", "and", "dose", "-", "escalation", "(", "low", "/", "high", "dose", ")", "in", "two", "adult", "age", "groups", "(", "young", "adults", "\\[18", "-", "59", "years\\", "]", "and", "older", "adults", "\\...	[ [ 1, 2, "Entity" ], [ 5, 9, "Entity" ], [ 18, 20, "Entity" ], [ 22, 23, "Entity" ], [ 51, 52, "Entity" ], [ 30, 31, "Entity" ], [ 58, 59, "Entity" ], [ 47, 48, "Entity" ], [ 54, 55...
[ "Dense", "-", "granule", "deficiency", "(", "DGD", ")", "is", "an", "inherited", "platelet", "disorder", "due", "to", "the", "absence", "of", "dense", "granules", "essential", "for", "activation", "of", "platelets", "in", "the", "event", "of", "vascular", "i...	[ [ 0, 6, "Condition" ], [ 9, 11, "Condition" ], [ 17, 18, "Biological entity" ], [ 33, 34, "Biological entity" ], [ 21, 23, "Biological process" ], [ 28, 29, "Event" ], [ 39, 40, "Diagnostic test" ], [ ...
[ "Single", "pre", "-", "operative", "dose", "of", "intravenous", "antibiotics", "with", "intraoperative", "redosing", "(", "SPD", "):", "Intravenous", "cefazolin", ",", "a", "cephalosporin", "antibiotic", ",", "will", "be", "prescribed", "to", "all", "patients", ...	[ [ 14, 15, "Drug" ], [ 18, 19, "Drug class" ], [ 26, 26, "Patient group" ], [ 31, 31, "Patient group" ], [ 28, 28, "Procedure" ], [ 34, 37, "Drug administration" ], [ 39, 43, "Timing" ], [ 47, 50, ...
[ "Obesity", "has", "become", "a", "global", "health", "problem", ".", "In", "recent", "years", ",", "the", "influence", "of", "dietary", "microbes", "in", "the", "obese", "population", "has", "attracted", "the", "attention", "of", "scholars", ".", "Our", "stu...	[ [ 0, 0, "Condition" ], [ 40, 40, "Condition" ], [ 124, 124, "Condition" ], [ 127, 127, "Condition" ], [ 154, 154, "Condition" ], [ 203, 203, "Condition" ], [ 219, 219, "Condition" ], [ 269, 269, ...
[ "The", "most", "recent", "statistics", "from", "the", "Department", "of", "Health", "in", "Ireland", "(", "2005", ")", "indicate", "that", "the", "leading", "causes", "of", "death", "are", "those", "in", "which", "nutrition", "can", "play", "a", "key", "pr...	[ [ 6, 10, "Organization" ], [ 12, 12, "Year" ], [ 25, 25, "Factor" ], [ 197, 197, "Factor" ], [ 41, 42, "Condition" ], [ 51, 52, "Condition" ], [ 45, 46, "Measurement" ], [ 55, 58, "Procedure" ...
[ "QTL", "mapping", "combined", "with", "genome", "-", "wide", "association", "studies", ",", "revealed", "a", " ", "potential", "candidate", "gene", "for", " ", "resistance", "to", " ", "northern", "leaf", "blight", "in", "the", "tropical", " ", "CATETO", "-"...	[ [ 0, 1, "Genetic analysis technique" ], [ 115, 116, "Genetic analysis technique" ], [ 4, 8, "Genetic analysis technique" ], [ 28, 33, "Maize line" ], [ 21, 23, "Disease" ], [ 46, 48, "Disease" ], [ 39, 42, "B...
[ "AIM", ":", "Wide", "volume", "scan", "(", "WVS", ")", "coronary", "computed", "tomography", "angiography", "(", "CCTA", ")", "enables", "aortic", "arch", "visualization", ".", "This", "study", "assessed", "whether", "the", "thoracic", "aortic", "plaque", "bur...	[ [ 2, 14, "Medical imaging technique" ], [ 16, 18, "Medical imaging goal" ], [ 25, 32, "Medical scoring system" ], [ 35, 41, "Medical condition" ], [ 49, 55, "Medical condition" ], [ 95, 101, "Medical scoring system" ], [...
[ "The", "invention", "relates", "to", "an", "amphoteric", "co", "-", "continuous", "polymer", "network", ".", "The", "amphoteric", "co", "-", "continuous", "polymer", "network", "is", "prepared", "through", "chemical", "crosslinking", "reaction", "by", "using", "...	[ [ 5, 10, "Material" ], [ 13, 18, "Material" ], [ 106, 111, "Material" ], [ 166, 171, "Material" ], [ 29, 31, "Material" ], [ 139, 141, "Material" ], [ 37, 40, "Material" ], [ 48, 49, "Material...
[ "Initial", "Therapy", ":", "In", "patients", "with", "uncomplicated", "essential", "hypertension", "not", "on", "diuretic", "therapy", ",", "the", "recommended", "initial", "dose", "is", "10", "mg", "once", "a", "day", ".", "Dosage", "should", "be", "adjusted"...	[ [ 0, 1, "Therapy" ], [ 6, 8, "Condition" ], [ 11, 12, "Therapy" ], [ 273, 274, "Therapy" ], [ 19, 23, "Dosage" ], [ 31, 33, "Response" ], [ 256, 258, "Response" ], [ 40, 45, "Dosage" ], [ ...
[ "Adipose", "tissue", "(", "AT", ")", "expansion", "through", "hyperplasia", "or", "hypertrophy", "requires", "vascular", "remodeling", "that", "involves", "angiogenesis", ".", "There", "is", "quite", "some", "evidence", "that", "obese", "white", "AT", "(", "WAT"...	[ [ 0, 5, "Biological process" ], [ 7, 9, "Biological process" ], [ 11, 12, "Biological process" ], [ 15, 15, "Biological process" ], [ 78, 78, "Biological process" ], [ 105, 105, "Biological process" ], [ 264, 264...
[ "Risk", "Summary", "\n\n", "There", "is", "no", "information", "available", "on", "the", "presence", "of", "SIGNIFOR", "LAR", "in", "human", "milk", ",", "the", "effects", "of", "the", "drug", "on", "the", "breastfed", "infant", ",", "or", "the", "effects"...	[ [ 12, 13, "Drug" ], [ 98, 99, "Drug" ], [ 111, 112, "Drug" ], [ 15, 16, "Substance" ], [ 73, 74, "Substance" ], [ 25, 26, "Individual" ], [ 35, 36, "Physiological process" ], [ 41, 41, "Drug" ...
[ "Participants", "receive", "rizatriptan", "tablets", ",", "administered", "orally", "as", "a", "single", "dose", "at", "onset", "of", "migraine", ".", "If", "still", "experiencing", "a", "migraine", "2", "hours", "after", "the", "first", "dose", "of", "rizatri...	[ [ 2, 3, "Drug" ], [ 9, 10, "Dosage" ], [ 12, 14, "Condition" ], [ 21, 22, "Time period" ], [ 25, 26, "Dose" ], [ 35, 36, "Dose" ], [ 41, 45, "Drug" ], [ 52, 53, "Quantity" ], [ 60, ...
[ "Individuals", "may", "decide", "to", "participate", "in", "the", "research", "study", "and", "agree", "to", "be", "randomized", ".", "These", "individuals", "will", "be", "immediately", "randomized", "into", "an", "immediate", "or", "a", "wait", "list", "cont...	[ [ 0, 0, "Entity" ], [ 16, 16, "Entity" ], [ 7, 8, "Entity" ], [ 13, 13, "Action" ], [ 20, 20, "Action" ], [ 23, 23, "Group" ], [ 32, 32, "Group" ], [ 26, 29, "Group" ], [ 47, 50, ...
[ "Following", "the", "submission", "of", "tumor", "tissue", "for", "the", "FoundationOne", "®", "companion", "diagnostic", "(", "F1CDx", ")", "test", ",", "participants", "with", "tumors", "that", "have", "a", "≥16%genomic", "loss", "of", "heterozygosity", "(", ...	[ [ 4, 5, "Biological sample" ], [ 8, 15, "Medical test" ], [ 17, 17, "Study subjects" ], [ 38, 38, "Study subjects" ], [ 45, 45, "Study subjects" ], [ 58, 58, "Study subjects" ], [ 37, 38, "Enrollment limit" ...
[ "Patients", "should", "be", "told", "that", "the", "anti", "-", "anginal", "efficacy", "of", "isosorbide", "dinitrate", "is", "strongly", "related", "to", "its", "dosing", "regimen", ",", "so", "the", "prescribed", "schedule", "of", "dosing", "should", "be", ...	[ [ 11, 12, "Drug" ], [ 41, 42, "Drug" ], [ 79, 80, "Drug" ], [ 110, 111, "Drug" ], [ 120, 121, "Drug" ], [ 131, 132, "Drug" ], [ 6, 9, "Effect" ], [ 93, 96, "Effect" ], [ 123, 126, ...
[ "Because", "clinical", "trials", "are", "conducted", "under", "widely", "varying", "conditions", ",", "adverse", "reaction", "rates", "observed", "in", "the", "clinical", "trials", "of", "a", "drug", "can", "not", "be", "directly", "compared", "to", "rates", "...	[ [ 1, 2, "Study design" ], [ 16, 17, "Study design" ], [ 30, 31, "Study design" ], [ 63, 64, "Study design" ], [ 84, 85, "Study design" ], [ 274, 275, "Study design" ], [ 10, 12, "Outcome measure" ], [ ...
[ "The", "active", "ingredient", "in", "Famotidine", "Injection", "is", "a", "histamine", "H2", "-", "receptor", "antagonist", ".", "Famotidine", "is", "N'-(aminosulfonyl)-3-[[[2-[(diaminomethylene)amino]-4", "-", "thiazolyl]methyl]thio]propanimidamide", ".", "The", "empirica...	[ [ 4, 5, "Drug product" ], [ 76, 77, "Drug product" ], [ 8, 12, "Drug class" ], [ 16, 18, "Chemical name" ], [ 26, 26, "Empirical formula" ], [ 32, 32, "Molecular weight" ], [ 43, 48, "Physical description" ...
[ "The", "present", "invention", "provides", "a", "membrane", "the", "conductivity", "of", "which", "is", "dependent", "on", "the", "presence", "or", "absence", "of", "an", "analyte", ".", " ", "The", "membrane", "comprises", "a", "closely", "packed", "array", ...	[ [ 5, 5, "Device" ], [ 23, 23, "Device" ], [ 85, 85, "Device" ], [ 128, 128, "Device" ], [ 206, 206, "Device" ], [ 236, 236, "Device" ], [ 272, 272, "Device" ], [ 7, 7, "Property" ], [ ...
[ "INTRODUCTION", ":", "Women", "with", "a", "prior", "stillbirth", "or", "a", "history", "of", "recurrent", "first", "trimester", "miscarriages", "are", "at", "increased", "risk", "of", "adverse", "pregnancy", "outcomes", ".", "However", ",", "little", "is", "k...	[ [ 2, 6, "Patient group" ], [ 9, 14, "Medical history" ], [ 20, 22, "Outcome" ], [ 67, 69, "Outcome" ], [ 34, 37, "Event" ], [ 39, 41, "Outcome" ], [ 77, 78, "Study type" ], [ 80, 81, "Study ty...
[ "&", "lt;P>PROBLEM", "TO", "BE", "SOLVED", ":", "To", "provide", "an", "implantable", "device", "which", "can", "convey", "a", "therapeutic", "agent", "to", "tissue", "or", "organs", "for", "a", "long", "period", "of", "time", ".", " ", "&", "lt;P>SO...	[ [ 9, 10, "Device" ], [ 15, 16, "Substance" ], [ 82, 83, "Substance" ], [ 18, 18, "Organ" ], [ 106, 106, "Organ" ], [ 20, 20, "Organ" ], [ 36, 36, "Shape" ], [ 56, 56, "Shape" ], [ 91, ...
[ "BACKGROUND", ":", "Iran", "is", "facing", "an", "epidemiological", "transition", "with", "the", "increasing", "burden", "of", "non", "-", "communicable", "diseases", ",", "such", "as", "obesity", "-", "related", "disorders", "and", "cardiovascular", "diseases", ...	[ [ 2, 2, "Country" ], [ 85, 85, "Country" ], [ 373, 373, "Country" ], [ 13, 16, "Disease category" ], [ 367, 370, "Disease category" ], [ 20, 23, "Disease category" ], [ 25, 29, "Disease category" ], [ ...
[ "A", "medical", "information", "system", ".", "In", "one", "embodiment", ",", "the", "medical", "information", "system", "includes", ":", "a", "learning", "engine", ";", "a", "user", "interface", "in", "communication", "with", "the", "learning", "engine", ";",...	[ [ 1, 3, "System" ], [ 10, 12, "System" ], [ 16, 17, "Component" ], [ 26, 27, "Component" ], [ 37, 38, "Component" ], [ 42, 43, "Component" ], [ 91, 92, "Component" ], [ 20, 21, "Component" ]...
[ "In", "spring", "2020", "four", "regions", "of", "France", "faced", "a", "surge", "of", "severe", "Coronavirus", "(", "COVID", ")", "patients", "which", "threatened", "to", "overflow", "local", "intensive", "care", "units", "(", "ICU", ")", "capacities", "."...	[ [ 6, 6, "Country" ], [ 1, 2, "Time period" ], [ 12, 16, "Patient group" ], [ 22, 28, "Medical facility" ], [ 36, 38, "Time period" ], [ 42, 43, "Patient group" ], [ 66, 69, "Medical procedure" ], [ 72...
[ "Endophytic", "bacterium", "Serratia", "plymuthica", "A30", "was", "identified", "as", "a", "superior", "biocontrol", "agent", "due", "to", "its", "effective", "colonization", "of", "potato", "tuber", ",", "tolerance", "to", "cold", "conditions", ",", "and", "st...	[ [ 2, 4, "Bacterium" ], [ 18, 19, "Plant part" ], [ 23, 24, "Environmental factor" ], [ 37, 38, "Pathogen" ], [ 42, 43, "Biological process" ], [ 70, 71, "Time period" ], [ 176, 177, "Time period" ], [ ...
[ "The", "invention", "relates", "to", "a", "traditional", "Chinese", "medicine", "composition", "for", "treating", "functional", "constipation", "and", "application", "thereof", ",", "wherein", "the", "traditional", "Chinese", "medicine", "composition", "is", "prepared...	[ [ 5, 8, "Drug" ], [ 19, 22, "Drug" ], [ 140, 143, "Drug" ], [ 170, 173, "Drug" ], [ 227, 230, "Drug" ], [ 11, 12, "Condition" ], [ 73, 74, "Condition" ], [ 146, 147, "Condition" ], [ 2...
[ "ProAmatine", "®", "is", "indicated", "for", "the", "treatment", "of", "symptomatic", "orthostatic", "hypotension", "(", "OH", ")", ".", "Because", "ProAmatine", "®", "can", "cause", "marked", "elevation", "of", "supine", "blood", "pressure", "(", "BP>200", "m...	[ [ 0, 0, "Drug" ], [ 16, 16, "Drug" ], [ 72, 72, "Drug" ], [ 107, 107, "Drug" ], [ 136, 136, "Drug" ], [ 145, 145, "Drug" ], [ 8, 13, "Condition" ], [ 23, 25, "Measurement" ], [ 44, ...
[ "Our", "federally", "qualified", "health", "care", "center", "serves", "over", "7000", "diabetic", "patients", ",", "many", "of", "whom", "are", "uninsured", "(", "43", "%", ")", "or", "on", "medicaid", "(", "18", "%", ")", "or", "medicare", "(", "26", ...	[ [ 1, 5, "Healthcare facility" ], [ 9, 10, "Patient group" ], [ 16, 16, "Insurance status" ], [ 23, 23, "Insurance program" ], [ 29, 29, "Insurance program" ], [ 40, 40, "Ethnicity" ], [ 44, 44, "Ethnicity" ...
[ "As", "with", "other", "NSAIDs", ",", "anaphylactic", "/", "anaphylactoid", "reactions", "may", "occur", "in", "patients", "without", "known", "prior", "exposure", "to", "indomethacin", ".", "Indomethacin", "should", "not", "be", "given", "to", "patients", "with...	[ [ 5, 8, "Adverse drug event" ], [ 18, 18, "Drug" ], [ 20, 20, "Drug" ], [ 97, 97, "Drug" ], [ 186, 186, "Drug" ], [ 229, 229, "Drug" ], [ 246, 246, "Drug" ], [ 301, 301, "Drug" ], [ 33...
[ "1,051,461", ".", "Topical", "compositions", "comprising", "fatty", "amines", ".", "GILLETTE", "CO", ".", "Oct.", "28", ",", "1964", ".", "[", "Nov.", "4", ",", "1963", "]", ",", "No", ".", "43965/64", ".", "Heading", "A5B.", "[", "Also", "in", "Divisi...	[ [ 2, 3, "Composition" ], [ 5, 6, "Component" ], [ 8, 9, "Assignee" ], [ 11, 14, "Date" ], [ 17, 20, "Date" ], [ 23, 25, "Patent number" ], [ 32, 35, "Classification" ], [ 56, 57, "Component" ...
[ "A", "prospective", "imaging", "ancillary", "study", "coincides", "with", "recruitment", "of", "ICTuS", "2", "by", "using", "currently", "available", "imaging", "tools", "at", "a", "subset", "of", "multicenter", "sites", ".", "HASTIER", "will", "evaluate", "ther...	[ [ 9, 10, "Clinical trial" ], [ 24, 24, "Study" ], [ 15, 16, "Medical device" ], [ 21, 22, "Research location" ], [ 27, 28, "Outcome measure" ], [ 30, 32, "Outcome measure" ], [ 34, 34, "Medical procedure" ]...
[ "Flavored", "dosage", "forms", ",", "e.g.", ",", "lozenges", "and", "gums", ",", "are", "provided", "for", "sustained", "release", "of", "a", "flavoring", "agent", "in", "the", "mouth", ".", "The", "dosage", "forms", "provide", "sustained", "release", "by", ...	[ [ 0, 2, "Drug product" ], [ 6, 6, "Dosage form" ], [ 128, 128, "Dosage form" ], [ 150, 150, "Dosage form" ], [ 8, 8, "Dosage form" ], [ 162, 162, "Dosage form" ], [ 17, 18, "Active pharmaceutical ingredient" ...
[ "Hypertension", ":", "The", "adult", "starting", "indapamide", "dose", "for", "hypertension", "is", "1.25", "mg", "as", "a", "single", "daily", "dose", "taken", "in", "the", "morning", ".", "If", "the", "response", "to", "1.25", "mg", "is", "not", "satisfa...	[ [ 0, 0, "Condition" ], [ 8, 8, "Condition" ], [ 5, 5, "Drug" ], [ 92, 92, "Drug" ], [ 145, 145, "Drug" ], [ 149, 149, "Drug" ], [ 10, 11, "Dosage" ], [ 26, 27, "Dosage" ], [ 14, 16...
[ "&", "lt;P>PROBLEM", "TO", "BE", "SOLVED", ":", "To", "provide", "an", "effective", "and", "safe", "anti", "-", "viral", "agent", "capable", "of", "being", "applied", "to", "fields", "such", "as", "medicines", ",", "cosmetics", ",", "foods", ",", "clean...	[ [ 12, 15, "Substance" ], [ 61, 61, "Substance" ], [ 80, 80, "Substance" ], [ 85, 85, "Substance" ], [ 64, 72, "Property" ], [ 84, 85, "Substance" ], [ 24, 24, "Field of application" ], [ 91, 91, ...
[ "This", "multi", "-", "center", "randomized", ",", "double", "-", "blind", ",", "placebo", "-", "controlled", "study", "will", "evaluate", "the", "safety", "of", "ABI", "-", "M201", "and", "its", "effects", "on", "disease", "activity", "measures", "in", "m...	[ [ 19, 21, "Drug" ], [ 133, 135, "Drug" ], [ 164, 166, "Drug" ], [ 45, 45, "Drug" ], [ 40, 40, "Condition" ], [ 10, 10, "Control" ], [ 137, 137, "Control" ], [ 168, 168, "Control" ], [ ...
[ "The", "recommended", "dosage", "range", "for", "FETZIMA", "is", "40", "mg", "to", "120", "mg", "once", "daily", ",", "with", "or", "without", "food", ".", "FETZIMA", "should", "be", "initiated", "at", "20", "mg", "once", "daily", "for", "2", "days", "...	[ [ 5, 5, "Drug" ], [ 20, 20, "Drug" ], [ 48, 48, "Drug" ], [ 77, 77, "Drug" ], [ 87, 87, "Drug" ], [ 7, 8, "Dosage" ], [ 36, 37, "Dosage" ], [ 55, 56, "Dosage" ], [ 10, 11, "Dos...
[ "Participants", "in", "this", "group", "will", "continue", "with", "their", "usual", "care", "for", "the", "first", "10", "weeks", "of", "the", "study", ".", "At", "week", "10", ",", "they", "will", "receive", "the", "same", "VIVA", "intervention", "." ]	[ [ 0, 0, "Study group" ], [ 8, 9, "Intervention" ], [ 12, 14, "Time period" ], [ 28, 29, "Intervention" ], [ 20, 21, "Time point" ] ]
[ "Prolonged", "use", "of", "high", "doses", "of", "orally", "active", "17", "-", "alpha", "-", "alkyl", "androgens", "(", "methyltestosterone", ")", "has", "been", "associated", "with", "serious", "hepatic", "adverse", "effects", "(", "peliosis", "hepatitis", "...	[ [ 8, 13, "Drug class" ], [ 15, 15, "Drug" ], [ 22, 24, "Adverse effects" ], [ 26, 27, "Adverse effect" ], [ 39, 40, "Adverse effect" ], [ 29, 30, "Adverse effect" ], [ 32, 33, "Adverse effect" ], [ 36...
[ "Two", "sterile", "gauzes", "will", "be", "dampen", "with", "the", "content", "of", "the", "second", "syringe", "(", "the", "content", "of", "the", "first", "syringe", "is", "always", "20", "ml", "of", "saline", "solution", "and", "it", "is", "the", "fir...	[ [ 1, 2, "Medical supply" ], [ 32, 33, "Medical supply" ], [ 11, 12, "Medical device" ], [ 69, 70, "Medical device" ], [ 22, 26, "Substance" ], [ 18, 19, "Medical device" ], [ 40, 45, "Substance" ], [ ...
[ "Matrix", "metalloproteinases", "(", "MMP", ")", "-2", "and", "-9", "belong", "to", "a", "multigene", "family", "of", "degradative", "enzymes", "implicated", "in", "the", "neoangiogenesis", "required", "for", "tumor", "growth", ".", "In", "the", "central", "ne...	[ [ 0, 7, "Biomarkers" ], [ 11, 12, "Gene family" ], [ 14, 15, "Enzymes" ], [ 19, 19, "Biological process" ], [ 22, 23, "Biological process" ], [ 27, 32, "Anatomical structure" ], [ 34, 34, "Biomarker" ], [...
[ "Breath", "testing", "utilizing", "13C", "is", "a", "safe", ",", "non", "-", "invasive", "means", "for", "measuring", "a", "certain", "pathway", "'s", "metabolic", "rate", ".", "13C", "is", "a", "stable", ",", "non", "-", "radioactive", "isotope", "which",...	[ [ 0, 1, "Medical test" ], [ 3, 3, "Isotope" ], [ 21, 21, "Isotope" ], [ 18, 19, "Measurement target" ], [ 24, 24, "Property of 13C" ], [ 26, 28, "Property of 13C" ], [ 40, 41, "Substance used in testing" ],...
[ "Idiopathic", "pulmonary", "fibrosis", "(", "IPF", ")", "is", "a", "scarring", "lung", "disease", ".", "It", "damages", "the", "air", "sacs", "that", "allow", "oxygen", "to", "be", "transferred", "into", "the", "blood", "and", "transported", "to", "vital", ...	[ [ 0, 5, "Disease" ], [ 9, 10, "Disease" ], [ 15, 16, "Anatomical structure" ], [ 19, 19, "Substance" ], [ 25, 25, "Substance" ], [ 29, 30, "Anatomical structure" ], [ 38, 38, "Symptom" ], [ 51, 51...
[ "PURPOSE", ":", "To", "obtain", "the", "titled", "preparation", "comprising", "human", "interferon", "as", "an", "active", "ingredient", ".", "CONSTITUTION", ":", "A", "solution", "containing", "human", "interferon", "(", "h", "-", "IFN", ":", "h", "-", "IFN...	[ [ 8, 9, "Active ingredient" ], [ 20, 21, "Active ingredient" ], [ 23, 25, "Abbreviation" ], [ 27, 29, "Abbreviation" ], [ 44, 46, "Abbreviation" ], [ 50, 52, "Abbreviation" ], [ 69, 71, "Abbreviation" ], ...
[ "The", "tumour", "evolution", "model", "posits", "that", "malignant", "transformation", "is", "preceded", "by", "randomly", "distributed", "driver", "mutations", "in", "cancer", "genes", ",", "which", "cause", "clonal", "expansions", "in", "phenotypically", "normal"...	[ [ 1, 3, "Model" ], [ 6, 7, "Process" ], [ 13, 14, "Mutation" ], [ 16, 17, "Gene" ], [ 21, 22, "Process" ], [ 29, 30, "Process" ], [ 107, 108, "Process" ], [ 152, 153, "Process" ], [ 26...
[ "A", "surgical", "resection", "is", "currently", "the", "preferred", "treatment", "for", "esophageal", "cancer", "if", "the", "tumor", "is", "considered", "to", "be", "resectable", "without", "evidence", "of", "distant", "metastases", ".", "A", "higher", "percen...	[ [ 9, 10, "Disease" ], [ 1, 2, "Treatment" ], [ 13, 13, "Condition" ], [ 36, 37, "Treatment" ], [ 46, 47, "Treatment" ], [ 53, 54, "Treatment" ], [ 141, 142, "Treatment" ], [ 58, 58, "Drug" ]...
[ "The", "participants", "will", "receive", "a", "link", "to", "the", "baseline", "survey", "at", "www.surveymonkey.com", ".", "After", "completing", "the", "survey", ",", "the", "participants", "will", "be", "randomized", "into", "an", "intervention", "or", "a", ...	[ [ 1, 1, "Study subjects" ], [ 19, 19, "Study subjects" ], [ 68, 68, "Study subjects" ], [ 83, 83, "Study subjects" ], [ 131, 131, "Study subjects" ], [ 152, 152, "Study subjects" ], [ 178, 178, "Study subject...
[ "All", "patients", "with", "active", "ulcerative", "colitis", "who", "present", "to", "the", "Outpatient", "department", "or", "the", "emergency", "services", "of", "PGIMER", "shall", "be", "screened", ".", "Those", "patients", "who", "have", "acute", "severe", ...	[ [ 4, 5, "Condition" ], [ 28, 29, "Condition" ], [ 10, 11, "Location" ], [ 14, 15, "Location" ], [ 17, 17, "Location" ], [ 26, 29, "Condition" ], [ 43, 44, "Criteria" ], [ 53, 54, "Study group"...
[ "Methylene", "Blue", "100", "mg", "capsules", ".", "Patients", "will", "receive", "Methylene", "blue", "(", "MB", ")", "capsules", "of", "100", "mg", "every", "12", "hours", "for", "a", "total", "of", "5", "days", "." ]	[ [ 0, 1, "Drug" ], [ 9, 10, "Drug" ], [ 2, 3, "Dosage" ], [ 4, 4, "Formulation" ], [ 14, 14, "Formulation" ], [ 18, 20, "Frequency" ], [ 25, 26, "Duration" ] ]
[ "The", "employment", "of", "machine", "learning", "approaches", "has", "shown", "promising", "results", "in", "predicting", "cancer", ".", "In", "the", "current", "study", ",", "polymorphisms", "data", "of", "five", "single", "nucleotide", "polymorphisms", "(", ...	[ [ 3, 4, "Approach" ], [ 12, 12, "Condition" ], [ 81, 81, "Condition" ], [ 92, 92, "Condition" ], [ 175, 175, "Condition" ], [ 19, 20, "Data type" ], [ 23, 33, "Genetic marker" ], [ 35, 36, "Ge...
[ "A", "method", "for", "analyzing", "an", "electrocardiography", "(", "ECG", ")", "signal", "is", "provided", ".", "The", "ECG", "signal", "is", "measured", "through", "a", "sensor", ".", "One", "or", "more", "specified", "waveforms", "in", "the", "ECG", "s...	[ [ 1, 1, "Patent component" ], [ 3, 3, "Action" ], [ 5, 9, "Signal" ], [ 20, 20, "Device" ], [ 25, 26, "Signal component" ], [ 35, 36, "Signal characteristic" ], [ 45, 46, "Signal characteristic" ], [ ...
[ "INTRODUCTION", ":", "The", "lateral", "antebrachial", "cutaneous", "nerve", "(", "LACN", ")", "is", "a", "somatosensory", "nerve", "coursing", "in", "the", "lateral", "portion", "of", "the", "forearm", ".", "The", "nerve", "is", "located", "in", "a", "close...	[ [ 3, 9, "Anatomical Structure" ], [ 12, 13, "Nerve Type" ], [ 21, 21, "Body Part" ], [ 71, 71, "Body Part" ], [ 33, 37, "Blood Vessel" ], [ 49, 49, "Medical Procedure" ], [ 336, 336, "Medical Procedure" ], ...
[ "Despite", "therapeutic", "advancements", ",", "cervical", "cancer", "caused", "by", "high", "-", "risk", "subtypes", "of", "the", "human", "papillomavirus", "(", "HPV", ")", "remains", "a", "leading", "cause", "of", "cancer", "-", "related", "deaths", "among"...	[ [ 4, 5, "Disease" ], [ 45, 46, "Plant" ], [ 52, 53, "Protein" ], [ 175, 176, "Protein" ], [ 290, 291, "Protein" ], [ 142, 142, "Compound" ], [ 163, 163, "Compound" ], [ 165, 165, "Compound" ...
[ "PURPOSE", ":", "To", "display", "retrieved", "check", "data", "in", "an", "optimum", "form", "by", "showing", "the", "attributes", "of", "the", "check", "data", "in", "a", "matrix", "of", "checking", "time", "points", "and", "checking", "items", "and", "v...	[ [ 5, 6, "Data" ], [ 17, 18, "Data" ], [ 14, 14, "Characteristics" ], [ 21, 21, "Data structure" ], [ 42, 42, "Data structure" ], [ 71, 71, "Data structure" ], [ 23, 25, "Time points" ], [ 27, 28, ...
[ "PURPOSE", ":", "A", "composition", "containing", "soybean", "fermentation", "is", "provided", "to", "ensure", "antibacterial", "effect", "and", "prevent", "and", "treat", "food", "poisoning", ".", "CONSTITUTION", ":", "A", "composition", "for", "preventing", "and...	[ [ 3, 3, "Entity" ], [ 23, 23, "Entity" ], [ 91, 91, "Entity" ], [ 5, 6, "Entity" ], [ 31, 32, "Entity" ], [ 39, 40, "Entity" ], [ 11, 12, "Effect" ], [ 17, 18, "Condition" ], [ 28, ...
[ "Commercially", "-", "available", "tomato", "food", "product", ":", "men", "in", "this", "group", "consumed", "V8", "®", "juice", "(", "11", "-", "16.5", "fl", ".", "oz./day", ")", "." ]	[ [ 0, 5, "Intervention" ], [ 7, 7, "Study group" ], [ 12, 14, "Intervention" ], [ 16, 21, "Dosage" ] ]
[ "Symptoms", "and", "Signs", "\n\n", "Symptoms", "following", "acute", "NSAIDs", "overdoses", "are", "usually", "limited", "to", "lethargy", ",", "drowsiness", ",", "nausea", ",", "vomiting", ",", "and", "epigastric", "pain", ",", "which", "are", "generally", "...	[ [ 7, 7, "Drug class" ], [ 64, 64, "Drug class" ], [ 87, 87, "Drug class" ], [ 13, 13, "Symptom" ], [ 15, 15, "Symptom" ], [ 17, 17, "Symptom" ], [ 187, 187, "Symptom" ], [ 19, 19, "Symptom" ...
[ "ASMANEX", "HFA", "is", "a", "metered", "dose", "inhaler", "for", "oral", "inhalation", "only", ",", "consisting", "of", "50", "mcg", ",", "100", "mcg", ",", "or", "200", "mcg", "of", "mometasone", "furoate", "per", "actuation", ".", "\n\n", "Mometasone", ...	[ [ 0, 1, "Drug product" ], [ 37, 38, "Drug product" ], [ 109, 110, "Drug product" ], [ 233, 234, "Drug product" ], [ 249, 250, "Drug product" ], [ 24, 25, "Active ingredient" ], [ 30, 31, "Active ingredient" ...
[ "Patients", "undergo", "collection", "of", "blood", "and", "urine", "samples", "on", "day", "1", ".", "Patients", "also", "undergo", "clinical", "assessments", ",", "laboratory", ",", "radiographic", ",", "and", "other", "ancillary", "studies", "on", "day", "1...	[ [ 0, 0, "Entity" ], [ 12, 12, "Entity" ], [ 6, 7, "Sample" ], [ 9, 10, "Time point" ], [ 27, 28, "Time point" ], [ 15, 16, "Procedure" ], [ 24, 25, "Procedure" ] ]
[ "Dexmedetomidine", "is", "a", "potent", "selective", "α-2", "-", "adrenergic", "receptor", "agonist", "frequently", "used", "for", "sedation", "in", "the", "ICU", ",", "also", "among", "critically", "ill", "patients", ".", "It", "promotes", "sedation", ",", "a...	[ [ 0, 0, "Drug" ], [ 16, 16, "Medical setting" ], [ 47, 47, "Medical setting" ], [ 13, 13, "Effect" ], [ 26, 26, "Effect" ], [ 28, 28, "Effect" ], [ 32, 32, "Effect" ], [ 35, 36, "Effect" ], ...
[ "The", "present", "invention", "relates", "to", ":", "a", "novel", "bacteriophage", "EC14", "having", "unique", "extinction", "capacity", "to", "a", "pathogenic", "colon", "bacillus", ",", "specifically", ",", "an", "enterotoxigenic", "E.", "coli", "(", "ETEC", ...	[ [ 8, 9, "Entity" ], [ 129, 130, "Entity" ], [ 166, 167, "Entity" ], [ 201, 202, "Entity" ], [ 228, 229, "Entity" ], [ 273, 274, "Entity" ], [ 16, 18, "Entity" ], [ 43, 45, "Entity" ], [ ...
[ "Investigators", "developed", "a", "brief", "standardized", "and", "manualized", "internet", "-", "delivered", "cognitive", "-", "behavioral", "(", "iCBT", ")", "program", "for", "treating", "anxious", "and", "depressive", "symptoms", "in", "children", "and", "ado...	[ [ 0, 0, "Researcher" ], [ 7, 16, "Intervention" ], [ 19, 22, "Condition" ], [ 24, 26, "Population" ], [ 90, 92, "Population" ], [ 31, 32, "Event" ], [ 34, 34, "Location" ], [ 41, 41, "Healthca...
[ "Over", "150,000", "soldiers", "are", "currently", "deployed", "in", "Iraq", "as", "part", "of", "Operation", "Iraqi", "Freedom", "(", "OIF", ")", ",", "and", "12", "%", "of", "returning", "OIF", "veterans", "have", "posttraumatic", "stress", "disorder", "("...	[ [ 11, 16, "Military operation" ], [ 7, 7, "Location" ], [ 339, 339, "Location" ], [ 454, 454, "Location" ], [ 488, 488, "Location" ], [ 26, 31, "Condition" ], [ 40, 41, "Military conflict" ], [ 49, ...
[ "This", "group", "is", "composed", "by", "20", "ALS", "subjects", "under", "600", "mg", "valproate", "and", "600", "mg", "of", "litium", "carbonate", "per", "day", ",", "during", "21", "months", ".", "The", "tablets", "are", "given", "orally", "with", "m...	[ [ 6, 7, "Patient group" ], [ 9, 11, "Drug dosage" ], [ 13, 17, "Drug dosage" ], [ 22, 23, "Duration" ], [ 26, 26, "Drug form" ], [ 29, 29, "Administration route" ], [ 30, 31, "Administration condition" ] ]
[ "Tramadol", "hydrochloride", "tablets", ",", "USP", "are", "an", "opioid", "agonist", ".", "The", "chemical", "name", "for", "tramadol", "hydrochloride", "is", "(", "±", ")", "cis-2-[(dimethylamino)methyl]-1-(3", "-", "methoxyphenyl", ")", "cyclohexanol", "hydrochlo...	[ [ 0, 4, "Drug product" ], [ 7, 8, "Drug class" ], [ 17, 25, "Chemical name" ], [ 47, 54, "Physical description" ], [ 58, 63, "Solubility" ], [ 67, 69, "Acid-base property" ], [ 84, 87, "logP value" ], [ ...
[ "PURPOSE", ":", "To", "prepare", "an", "antibiotic", "composition", "preservable", "for", "a", "long", "period", ",", "by", "using", "a", "penicillanic", "acid", "salt", "in", "combination", "with", "an", "additive", "composed", "of", "cyclic", "monosaccharide",...	[ [ 5, 6, "Substance" ], [ 161, 162, "Substance" ], [ 16, 18, "Substance" ], [ 23, 23, "Substance" ], [ 64, 64, "Substance" ], [ 144, 144, "Substance" ], [ 26, 27, "Substance" ], [ 31, 32, "Subs...
[ "The", "acyl", "-", "β", "-", "glucuronide", "metabolite", "of", "clopidogrel", "is", "a", "strong", "inhibitor", "of", "CYP2C8", ".", "Clopidogrel", "can", "increase", "the", "systemic", "exposure", "to", "drugs", "that", "are", "primarily", "cleared", "by", ...	[ [ 8, 8, "Drug" ], [ 16, 16, "Drug" ], [ 44, 44, "Drug" ], [ 72, 72, "Drug" ], [ 105, 105, "Drug" ], [ 1, 6, "Metabolite" ], [ 14, 14, "Enzyme" ], [ 29, 29, "Enzyme" ], [ 46, 46, ...
[ "Participants", "will", "be", "advised", "to", "use", "a", "Probiotic", "toothpaste", "twice", "a", "day", "for", "3", "weeks", "after", "the", "bonding", ".", "A", "probiotic", "toothpaste", "and", "a", "standard", "brushing", "technique", "will", "be", "co...	[ [ 0, 0, "Study subject" ], [ 33, 33, "Study subject" ], [ 7, 8, "Intervention" ], [ 20, 21, "Intervention" ], [ 24, 26, "Intervention" ], [ 17, 17, "Procedure" ] ]
[ "Although", "cognitive", "-", "behavioral", "therapy", "(", "CBT", ")", "is", "the", "most", "effective", "intervention", "for", "pediatric", "obsessive", "-", "compulsive", "disorder", "(", "OCD", ")", ",", "many", "people", "do", "receive", "CBT", "initially...	[ [ 1, 7, "Intervention" ], [ 14, 21, "Condition" ], [ 61, 62, "Treatment" ], [ 74, 75, "Treatment" ], [ 143, 148, "Intervention" ], [ 157, 158, "Study population" ], [ 165, 167, "Intervention arm" ], [ ...
[ "There", "is", "no", "known", "antidote", "for", "overdoses", "of", "lapatinib", "tablets", ".", "The", "maximum", "oral", "doses", "of", "lapatinib", "that", "have", "been", "administered", "in", "clinical", "trials", "are", "1,800", "mg", "once", "daily", ...	[ [ 8, 9, "Drug" ], [ 34, 35, "Drug" ], [ 179, 180, "Drug" ], [ 6, 6, "Condition" ], [ 22, 23, "Study" ], [ 45, 46, "Study" ], [ 25, 28, "Dosage" ], [ 51, 52, "Risk" ], [ 56, 57, ...
[ "Adults", "\n\n", "Adult", "surgical", "patients", "receiving", "general", "balanced", "anesthesia", "(", "barbiturate", ":", "thiopental", ",", "methohexital", ",", "or", "thiamylal", ";", "opioid", ":", "alfentanil", "or", "fentanyl", ";", "nitrous", "oxide", ...	[ [ 0, 0, "Patient group" ], [ 134, 134, "Patient group" ], [ 3, 4, "Patient subgroup" ], [ 6, 8, "Anesthesia type" ], [ 12, 12, "Drug" ], [ 14, 14, "Drug" ], [ 17, 17, "Drug" ], [ 21, 21, "Drug...

[ "People", "with", "moderate", "to", "severe", "chronic", "obstructive", "pulmonary", "disease", "(", "COPD", ")", "experience", "intense", "symptoms", "of", "dyspnea", "when", "they", "use", "their", "arms", "and", "shoulders", ".", "To", "control", "dyspnea", ...

[ [ 2, 11, "Condition" ], [ 16, 16, "Symptom" ], [ 27, 27, "Symptom" ], [ 212, 212, "Symptom" ], [ 21, 23, "Body parts" ], [ 40, 45, "Physical attribute" ], [ 53, 54, "Activity level" ], [ 57, 59, ...

[ "Carcinogenesis", "The", "carcinogenic", "potential", "of", "orally", "administered", "frovatriptan", "was", "evaluated", "in", "an", "84", "-", "week", "study", "in", "mice", "(", "4", ",", "13", ",", "and", "40", "mg", "/", "kg", "/", "day", ")", ",", ...

[ [ 7, 7, "Drug" ], [ 268, 268, "Drug" ], [ 294, 294, "Drug" ], [ 306, 306, "Drug" ], [ 338, 338, "Drug" ], [ 17, 17, "Animal model" ], [ 63, 63, "Animal model" ], [ 38, 38, "Animal model" ], ...

[ "BACKGROUND", ":", "Calcium", "(", "Ca", ")", "is", "a", "nutritional", "factor", "that", "associated", "with", "dental", "caries", ".", "A", "recent", "study", "showed", "that", "in", "the", "case", "of", "adequate", "Ca", "intake", ",", "a", "higher", ...

[ [ 2, 5, "Nutritional factor" ], [ 13, 14, "Disease" ], [ 70, 71, "Disease" ], [ 142, 143, "Disease" ], [ 190, 191, "Disease" ], [ 208, 209, "Disease" ], [ 296, 297, "Disease" ], [ 403, 404, "D...

[ "The", "present", "invention", "relates", "to", "a", "traditional", "Chinese", "medicine", "for", "treating", "hypertension", "emergency", ",", "which", "is", "derived", "from", "a", "clinical", "empirical", "prescription", ".", "The", "traditional", "Chinese", "m...

[ [ 11, 12, "Condition" ], [ 128, 129, "Condition" ], [ 323, 324, "Condition" ], [ 6, 8, "Treatment" ], [ 24, 26, "Treatment" ], [ 35, 36, "Ingredient" ], [ 43, 45, "Ingredient" ], [ 52, 53, "In...

[ "Hypercholesterolemia", "(", "Heterozygous", "Familial", "and", "Nonfamilial", ")", "and", "Mixed", "Dyslipidemia", "(", "Fredrickson", "Types", "IIa", "and", "IIb", ")", "\n\n", "The", "effects", "of", "fenofibrate", "at", "a", "dose", "equivalent", "to", "200"...

[ [ 0, 0, "Condition" ], [ 2, 3, "Subtype" ], [ 5, 5, "Subtype" ], [ 8, 9, "Condition" ], [ 11, 15, "Subtype" ], [ 21, 21, "Drug" ], [ 29, 29, "Drug" ], [ 90, 90, "Drug" ], [ 112, 11...

[ "In", "2018", ",", "rTMS", "received", "approval", "from", "the", "U.S.", "Food", "and", "Drug", "Administration", "(", "FDA", ")", "for", "the", "treatment", "of", "OCD", ".", "Based", "on", "randomized", "clinical", "trials", ",", "researchers", "have", ...

[ [ 3, 3, "Treatment" ], [ 174, 174, "Treatment" ], [ 249, 249, "Treatment" ], [ 275, 275, "Treatment" ], [ 8, 15, "Organization" ], [ 1, 1, "Year" ], [ 20, 20, "Condition" ], [ 73, 73, "Conditi...

[ "In", "active", "tACS", ",", "the", "target", "'", "active", "'", "electrode", "was", "placed", "over", "the", "MFC", "and", "the", "second", "'", "return", "'", "electrode", "was", "placed", "over", "the", "medial", "parietal", "cortex", ".", "6", "Hz",...

[ [ 1, 2, "Medical procedure" ], [ 5, 9, "Device" ], [ 14, 14, "Anatomical structure" ], [ 17, 21, "Device" ], [ 26, 28, "Anatomical structure" ], [ 30, 32, "Stimulation frequency" ], [ 37, 38, "Stimulation typ...

[ "Wilson", "'s", "disease", "(", "hepatolenticular", "degeneration", ")", "occurs", "in", "individuals", "who", "have", "inherited", "an", "autosomal", "recessive", "defect", "that", "leads", "to", "an", "accumulation", "of", "copper", "far", "in", "excess", "of"...

[ [ 0, 2, "Disease" ], [ 115, 117, "Disease" ], [ 4, 5, "Synonym" ], [ 14, 16, "Genetic condition" ], [ 23, 23, "Substance" ], [ 33, 33, "Substance" ], [ 69, 69, "Substance" ], [ 175, 175, "Subs...

[ "Microglia", ",", "the", "resident", "immune", "cells", "of", "the", "central", "nervous", "system", "(", "CNS", ")", ",", "have", "received", "significant", "attention", "due", "to", "their", "critical", "roles", "in", "maintaining", "brain", "homeostasis", "...

[ [ 0, 0, "Cell type" ], [ 38, 38, "Cell type" ], [ 52, 52, "Cell type" ], [ 67, 67, "Cell type" ], [ 109, 109, "Cell type" ], [ 159, 159, "Cell type" ], [ 177, 177, "Cell type" ], [ 188, 188, "...

[ "Effective", "exudate", "management", "is", "key", "for", "optimal", "ulcer", "healing", ".", "Superabsorbent", "dressings", "are", "designed", "to", "have", "high", "fluid", "handling", "capacity", ",", "reduced", "risk", "of", "exudate", "leakage", ",", "fluid...

[ [ 0, 2, "Concept" ], [ 7, 8, "Outcome" ], [ 10, 11, "Intervention" ], [ 56, 57, "Intervention" ], [ 199, 200, "Intervention" ], [ 211, 212, "Intervention" ], [ 269, 270, "Intervention" ], [ 16, 19...

[ "The", "purpose", "of", "this", "study", "is", "to", "pilot", "test", "a", "newly", "developed", "strengths", "-", "based", "clinical", "intervention", "delivered", "by", "diabetes", "care", "providers", "in", "the", "context", "of", "routine", "ambulatory", "...

[ [ 4, 4, "Research study" ], [ 16, 16, "Clinical intervention" ], [ 53, 53, "Clinical intervention" ], [ 100, 100, "Clinical intervention" ], [ 110, 110, "Clinical intervention" ], [ 177, 177, "Clinical intervention" ], [...

[ "Subjects", "will", "receive", "EnteraGam", "®", "(", "oral", "nutritional", "therapy", ")", "+", "standard", "of", "care", "for", "COVID-19", "for", "2", "weeks", ".", "Total", "study", "duration", "(", "including", "the", "screening", "phase", ")", "will",...

[ [ 3, 4, "Drug" ], [ 6, 8, "Treatment" ], [ 11, 15, "Treatment" ], [ 17, 18, "Duration" ], [ 32, 33, "Duration" ] ]

[ "The", "Device", "has", "the", "promise", "of", "providing", "a", "novel", "mechanism", "for", "reducing", "or", "preventing", "the", "likelihood", "of", "TBI", ",", "and", "may", "be", "used", "in", "conjunction", "with", "other", "protective", "equipment", ...

[ [ 1, 1, "Intervention" ], [ 120, 120, "Intervention" ], [ 437, 437, "Intervention" ], [ 456, 456, "Intervention" ], [ 493, 493, "Intervention" ], [ 510, 510, "Intervention" ], [ 536, 536, "Intervention" ], ...

[ "Cisplatin", "injection", "is", "a", "highly", "emetogenic", "antineoplastic", "agent", ".", "Premedicate", "with", "anti", "-", "emetic", "agents", "[", "see", "Dosage", "and", "Administration", "(", "2.1", ")", "]", ".", "Without", "antiemetic", "therapy", "...

[ [ 0, 1, "Drug" ], [ 40, 41, "Drug" ], [ 129, 130, "Drug" ], [ 6, 7, "Drug class" ], [ 11, 14, "Drug class" ], [ 17, 19, "Section" ], [ 30, 32, "Adverse drug event" ], [ 54, 56, "Adverse drug e...

[ "Group", "1", ":", "25", "healthy", "lean", "men", "(", "age", "30", "-", "45", ",", "BMI", "\\<28", ")", "with", "genetic", "predisposition", "for", "type", "2", "diabetes", "mellitus", "(", "T2DM", ")", "-", "i.e.", "their", "two", "first", "-", "d...

[ [ 0, 1, "Study group" ], [ 3, 6, "Participant characteristics" ], [ 8, 11, "Age range" ], [ 17, 66, "Inclusion criteria" ], [ 71, 92, "Exclusion criteria" ] ]

[ "Type", "2", "diabetes", "mellitus", "is", "regarded", "as", "one", "of", "the", "most", "prevalent", "disease", "of", "the", "adult", "population", ".", "In", "many", "developing", "countries", ",", "this", "condition", "is", "regarded", "as", "major", "pub...

[ [ 0, 3, "Disease" ], [ 15, 16, "Population group" ], [ 20, 21, "Location" ], [ 29, 31, "Health issue" ], [ 38, 39, "Condition" ], [ 42, 44, "Symptom" ], [ 50, 51, "Condition" ], [ 54, 55, "Con...

[ "Although", "endovascular", "treatment", "(", "EVT", ")", "has", "developed", "and", "still", "progressing", ",", "calcified", "lesions", "remain", "a", "big", "challenge", "to", "operators", "in", "obtaining", "good", "results", ".", "Whenever", ",", "the", "...

[ [ 1, 5, "Medical procedure" ], [ 12, 13, "Medical condition" ], [ 28, 33, "Medical condition" ], [ 37, 38, "Medical procedure" ], [ 43, 44, "Medical condition" ], [ 52, 57, "Patient" ], [ 60, 65, "Medical con...

[ "The", "invention", "discloses", "a", "traditional", "Chinese", "medicine", "composition", "for", "treating", "cold", "-", "dampness", "blockage", "type", "calcaneodynia", "and", "a", "preparation", "method", "thereof", ".", "The", "traditional", "Chinese", "medicin...

[ [ 4, 7, "Drug" ], [ 23, 26, "Drug" ], [ 195, 198, "Drug" ], [ 10, 15, "Condition" ], [ 203, 208, "Condition" ], [ 222, 227, "Condition" ], [ 42, 52, "Ingredient" ], [ 59, 60, "Ingredient" ],...

[ "PURPOSE", ":", "The", "objective", "of", "this", "retrospective", "cohort", "study", "was", "to", "investigate", "the", "predictive", "value", "of", "stress", "-", "induced", "hyperglycemia", "parameters", "for", "delayed", "healing", "after", "tibial", "fracture...

[ [ 16, 20, "Medical term" ], [ 70, 74, "Medical term" ], [ 167, 171, "Medical term" ], [ 221, 225, "Medical term" ], [ 246, 250, "Medical term" ], [ 287, 291, "Medical term" ], [ 22, 23, "Medical condition" ...

[ "Keloid", "scars", ",", "characterized", "by", "abnormal", "fibroproliferation", "and", "excessive", "extracellular", "matrix", "(", "ECM", ")", "production", "that", "extends", "beyond", "the", "original", "wound", ",", "often", "cause", "pruritus", ",", "pain", ...

[ [ 0, 1, "Condition" ], [ 204, 205, "Condition" ], [ 5, 6, "Pathological process" ], [ 8, 14, "Pathological process" ], [ 24, 24, "Symptom" ], [ 26, 26, "Symptom" ], [ 29, 29, "Symptom" ], [ 34, 36...

[ "BACKGROUND", ":", "A", "care", "bundle", "comprises", "a", "set", "of", "evidence", "-", "based", "practices", "in", "patient", "care", "that", "are", "grouped", "together", "with", "the", "assumption", "that", "these", "practices", "when", "performed", "toge...

[ [ 3, 4, "Medical intervention" ], [ 244, 245, "Medical intervention" ], [ 9, 12, "Medical practices" ], [ 14, 15, "Medical care" ], [ 33, 34, "Medical outcomes" ], [ 46, 46, "Medical devices" ], [ 56, 59, "In...

[ "Methadone", "Hydrochloride", "Oral", "Concentrate", ",", "USP", "dye", "-", "free", ",", "sugar", "-", "free", ",", "unflavored", "contains", "methadone", ",", "an", "opioid", "agonist", ",", "and", "is", "available", "as", "a", "dye", "-", "free", ",", ...

[ [ 0, 5, "Drug product" ], [ 0, 0, "Active pharmaceutical ingredient" ], [ 16, 16, "Active pharmaceutical ingredient" ], [ 39, 39, "Active pharmaceutical ingredient" ], [ 46, 46, "Active pharmaceutical ingredient" ], [ 59, 59, ...

[ "INTRODUCTION", ":", "Pisa", "syndrome", "(", "PS", ")", "is", "a", "postural", "abnormality", "that", "frequently", "manifests", "in", "various", "neurological", "disorders", ".", "In", "recent", "years", ",", "the", "dangers", "associated", "with", "Parkinson"...

[ [ 2, 6, "Condition" ], [ 27, 32, "Condition" ], [ 80, 80, "Treatment" ], [ 95, 95, "Treatment" ], [ 117, 117, "Treatment" ], [ 172, 172, "Treatment" ], [ 192, 192, "Treatment" ], [ 205, 205, "...

[ "Immunogenic", "compositions", "and", "methods", "for", "eliciting", "an", "immune", "response", "against", "S.", "epiderrnidis", "and", "other", "related", "staphylococci", "are", "provided", ".", "The", "immunogenic", "compositions", "can", "include", "immunogenic",...

[ [ 0, 1, "Composition" ], [ 20, 21, "Composition" ], [ 7, 8, "Biological process" ], [ 54, 55, "Biological process" ], [ 10, 11, "Pathogen" ], [ 15, 15, "Pathogen" ], [ 41, 41, "Pathogen" ], [ 62, ...

[ "There", "is", "a", "current", "need", "to", "develop", "a", "split", "-", "dose", "cisplatinum", "regimen", "in", "combination", "with", "pemetrexed", "with", "high", "efficacy", ",", "excellent", "treatment", "compliance", ",", "administration", "convenience", ...

[ [ 11, 12, "Treatment protocol" ], [ 16, 16, "Chemotherapy drug" ], [ 18, 19, "Outcome measure" ], [ 21, 23, "Outcome measure" ], [ 25, 26, "Outcome measure" ], [ 34, 35, "Treatment setting" ], [ 45, 53, "Dosa...

[ "Treatment", "with", "placebo", "combined", "with", "vedolizumab", ";", "Subjects", "will", "receive", "two", "sachets", "daily", "of", "Placebo", "for", "14", "weeks", ".", "Vedolizumab", "will", "be", "administere", "as", "per", "clinical", "practice", "with",...

[ [ 2, 2, "Drug" ], [ 14, 14, "Drug" ], [ 5, 5, "Drug" ], [ 19, 19, "Drug" ], [ 11, 11, "Dosage form" ], [ 12, 12, "Frequency" ], [ 16, 17, "Duration" ], [ 42, 43, "Duration" ], [ 25, ...

[ "Aims", ":", "Seawater", "immersion", "significantly", "aggravated", "organ", "dysfunction", "following", "hemorrhagic", "shock", ",", "leading", "to", "higher", "mortality", "rate", ".", "However", ",", "the", "effective", "treatment", "is", "still", "unavailable",...

[ [ 2, 3, "Condition" ], [ 51, 52, "Condition" ], [ 73, 74, "Condition" ], [ 110, 111, "Condition" ], [ 232, 233, "Condition" ], [ 253, 254, "Condition" ], [ 9, 10, "Condition" ], [ 55, 56, "Con...

[ "FIELD", ":", "medicine", ".", "SUBSTANCE", ":", "invention", "relates", "to", "the", "development", "of", "drugs", "of", "natural", "origin", "showing", "the", "broad", "spectrum", "of", "pharmacological", "effect", ".", "Invention", "proposes", "two", "agents"...

[ [ 2, 2, "Field of study" ], [ 12, 15, "Substance" ], [ 21, 22, "Effect" ], [ 26, 27, "Substance" ], [ 33, 33, "Substance" ], [ 97, 97, "Substance" ], [ 39, 40, "Substance" ], [ 47, 48, "Substa...

[ "This", "trial", "is", "open", "-", "label", ",", "prospective", "intervention", "study", ".", "A", "total", "of", "150", "subjects", "who", "had", "previously", "received", "complete", "primary", "doses", "of", "IndoVac", "®", "in", "phase", "III", "and", ...

[ [ 24, 25, "Vaccine" ], [ 27, 28, "Clinical trial phase" ], [ 14, 15, "Sample size" ], [ 40, 41, "Document" ], [ 55, 56, "Dosage" ], [ 60, 62, "Vaccine administration" ], [ 70, 70, "Outcome measure" ], [ ...

[ "Immunosuppressed", "patients", "are", "at", "increased", "risk", "for", "opportunistic", "infections", ",", "including", "activation", "of", "latent", "viral", "infections", ".", "These", "include", "BK", "virus", "-", "associated", "nephropathy", ",", "which", "...

[ [ 0, 1, "Patient group" ], [ 153, 154, "Patient group" ], [ 7, 8, "Condition" ], [ 13, 15, "Condition" ], [ 19, 23, "Condition" ], [ 74, 78, "Condition" ], [ 92, 96, "Condition" ], [ 30, 32, "...

[ "Neuromyelitis", "optica", "spectrum", "disorder", "(", "NMOSD", ")", "is", "a", "severe", "form", "of", "inflammation", "of", "the", "central", "nervous", "system", "(", "CNS", ")", "including", "acute", "myelitis", ",", "optic", "neuritis", "and", "brain", ...

[ [ 0, 6, "Disease" ], [ 15, 20, "Anatomical structure" ], [ 22, 23, "Symptom" ], [ 25, 26, "Symptom" ], [ 28, 29, "Symptom" ], [ 39, 40, "Diagnostic test" ], [ 47, 54, "Serological marker" ], [ 75, ...

[ "The", "study", "design", "includes", "an", "age-", "and", "dose", "-", "escalation", "(", "low", "/", "high", "dose", ")", "in", "two", "adult", "age", "groups", "(", "young", "adults", "\\[18", "-", "59", "years\\", "]", "and", "older", "adults", "\\...

[ [ 1, 2, "Entity" ], [ 5, 9, "Entity" ], [ 18, 20, "Entity" ], [ 22, 23, "Entity" ], [ 51, 52, "Entity" ], [ 30, 31, "Entity" ], [ 58, 59, "Entity" ], [ 47, 48, "Entity" ], [ 54, 55...

[ "Dense", "-", "granule", "deficiency", "(", "DGD", ")", "is", "an", "inherited", "platelet", "disorder", "due", "to", "the", "absence", "of", "dense", "granules", "essential", "for", "activation", "of", "platelets", "in", "the", "event", "of", "vascular", "i...

[ [ 0, 6, "Condition" ], [ 9, 11, "Condition" ], [ 17, 18, "Biological entity" ], [ 33, 34, "Biological entity" ], [ 21, 23, "Biological process" ], [ 28, 29, "Event" ], [ 39, 40, "Diagnostic test" ], [ ...

[ "Single", "pre", "-", "operative", "dose", "of", "intravenous", "antibiotics", "with", "intraoperative", "redosing", "(", "SPD", "):", "Intravenous", "cefazolin", ",", "a", "cephalosporin", "antibiotic", ",", "will", "be", "prescribed", "to", "all", "patients", ...

[ [ 14, 15, "Drug" ], [ 18, 19, "Drug class" ], [ 26, 26, "Patient group" ], [ 31, 31, "Patient group" ], [ 28, 28, "Procedure" ], [ 34, 37, "Drug administration" ], [ 39, 43, "Timing" ], [ 47, 50, ...

[ "Obesity", "has", "become", "a", "global", "health", "problem", ".", "In", "recent", "years", ",", "the", "influence", "of", "dietary", "microbes", "in", "the", "obese", "population", "has", "attracted", "the", "attention", "of", "scholars", ".", "Our", "stu...

[ [ 0, 0, "Condition" ], [ 40, 40, "Condition" ], [ 124, 124, "Condition" ], [ 127, 127, "Condition" ], [ 154, 154, "Condition" ], [ 203, 203, "Condition" ], [ 219, 219, "Condition" ], [ 269, 269, ...

[ "The", "most", "recent", "statistics", "from", "the", "Department", "of", "Health", "in", "Ireland", "(", "2005", ")", "indicate", "that", "the", "leading", "causes", "of", "death", "are", "those", "in", "which", "nutrition", "can", "play", "a", "key", "pr...

[ [ 6, 10, "Organization" ], [ 12, 12, "Year" ], [ 25, 25, "Factor" ], [ 197, 197, "Factor" ], [ 41, 42, "Condition" ], [ 51, 52, "Condition" ], [ 45, 46, "Measurement" ], [ 55, 58, "Procedure" ...

[ "QTL", "mapping", "combined", "with", "genome", "-", "wide", "association", "studies", ",", "revealed", "a", " ", "potential", "candidate", "gene", "for", " ", "resistance", "to", " ", "northern", "leaf", "blight", "in", "the", "tropical", " ", "CATETO", "-"...

[ [ 0, 1, "Genetic analysis technique" ], [ 115, 116, "Genetic analysis technique" ], [ 4, 8, "Genetic analysis technique" ], [ 28, 33, "Maize line" ], [ 21, 23, "Disease" ], [ 46, 48, "Disease" ], [ 39, 42, "B...

[ "AIM", ":", "Wide", "volume", "scan", "(", "WVS", ")", "coronary", "computed", "tomography", "angiography", "(", "CCTA", ")", "enables", "aortic", "arch", "visualization", ".", "This", "study", "assessed", "whether", "the", "thoracic", "aortic", "plaque", "bur...

[ [ 2, 14, "Medical imaging technique" ], [ 16, 18, "Medical imaging goal" ], [ 25, 32, "Medical scoring system" ], [ 35, 41, "Medical condition" ], [ 49, 55, "Medical condition" ], [ 95, 101, "Medical scoring system" ], [...

[ "The", "invention", "relates", "to", "an", "amphoteric", "co", "-", "continuous", "polymer", "network", ".", "The", "amphoteric", "co", "-", "continuous", "polymer", "network", "is", "prepared", "through", "chemical", "crosslinking", "reaction", "by", "using", "...

[ [ 5, 10, "Material" ], [ 13, 18, "Material" ], [ 106, 111, "Material" ], [ 166, 171, "Material" ], [ 29, 31, "Material" ], [ 139, 141, "Material" ], [ 37, 40, "Material" ], [ 48, 49, "Material...

[ "Initial", "Therapy", ":", "In", "patients", "with", "uncomplicated", "essential", "hypertension", "not", "on", "diuretic", "therapy", ",", "the", "recommended", "initial", "dose", "is", "10", "mg", "once", "a", "day", ".", "Dosage", "should", "be", "adjusted"...

[ [ 0, 1, "Therapy" ], [ 6, 8, "Condition" ], [ 11, 12, "Therapy" ], [ 273, 274, "Therapy" ], [ 19, 23, "Dosage" ], [ 31, 33, "Response" ], [ 256, 258, "Response" ], [ 40, 45, "Dosage" ], [ ...

[ "Adipose", "tissue", "(", "AT", ")", "expansion", "through", "hyperplasia", "or", "hypertrophy", "requires", "vascular", "remodeling", "that", "involves", "angiogenesis", ".", "There", "is", "quite", "some", "evidence", "that", "obese", "white", "AT", "(", "WAT"...

[ [ 0, 5, "Biological process" ], [ 7, 9, "Biological process" ], [ 11, 12, "Biological process" ], [ 15, 15, "Biological process" ], [ 78, 78, "Biological process" ], [ 105, 105, "Biological process" ], [ 264, 264...

[ "Risk", "Summary", "\n\n", "There", "is", "no", "information", "available", "on", "the", "presence", "of", "SIGNIFOR", "LAR", "in", "human", "milk", ",", "the", "effects", "of", "the", "drug", "on", "the", "breastfed", "infant", ",", "or", "the", "effects"...

[ [ 12, 13, "Drug" ], [ 98, 99, "Drug" ], [ 111, 112, "Drug" ], [ 15, 16, "Substance" ], [ 73, 74, "Substance" ], [ 25, 26, "Individual" ], [ 35, 36, "Physiological process" ], [ 41, 41, "Drug" ...

[ "Participants", "receive", "rizatriptan", "tablets", ",", "administered", "orally", "as", "a", "single", "dose", "at", "onset", "of", "migraine", ".", "If", "still", "experiencing", "a", "migraine", "2", "hours", "after", "the", "first", "dose", "of", "rizatri...

[ [ 2, 3, "Drug" ], [ 9, 10, "Dosage" ], [ 12, 14, "Condition" ], [ 21, 22, "Time period" ], [ 25, 26, "Dose" ], [ 35, 36, "Dose" ], [ 41, 45, "Drug" ], [ 52, 53, "Quantity" ], [ 60, ...

[ "Individuals", "may", "decide", "to", "participate", "in", "the", "research", "study", "and", "agree", "to", "be", "randomized", ".", "These", "individuals", "will", "be", "immediately", "randomized", "into", "an", "immediate", "or", "a", "wait", "list", "cont...

[ [ 0, 0, "Entity" ], [ 16, 16, "Entity" ], [ 7, 8, "Entity" ], [ 13, 13, "Action" ], [ 20, 20, "Action" ], [ 23, 23, "Group" ], [ 32, 32, "Group" ], [ 26, 29, "Group" ], [ 47, 50, ...

[ "Following", "the", "submission", "of", "tumor", "tissue", "for", "the", "FoundationOne", "®", "companion", "diagnostic", "(", "F1CDx", ")", "test", ",", "participants", "with", "tumors", "that", "have", "a", "≥16%genomic", "loss", "of", "heterozygosity", "(", ...

[ [ 4, 5, "Biological sample" ], [ 8, 15, "Medical test" ], [ 17, 17, "Study subjects" ], [ 38, 38, "Study subjects" ], [ 45, 45, "Study subjects" ], [ 58, 58, "Study subjects" ], [ 37, 38, "Enrollment limit" ...

[ "Patients", "should", "be", "told", "that", "the", "anti", "-", "anginal", "efficacy", "of", "isosorbide", "dinitrate", "is", "strongly", "related", "to", "its", "dosing", "regimen", ",", "so", "the", "prescribed", "schedule", "of", "dosing", "should", "be", ...

[ [ 11, 12, "Drug" ], [ 41, 42, "Drug" ], [ 79, 80, "Drug" ], [ 110, 111, "Drug" ], [ 120, 121, "Drug" ], [ 131, 132, "Drug" ], [ 6, 9, "Effect" ], [ 93, 96, "Effect" ], [ 123, 126, ...

[ "Because", "clinical", "trials", "are", "conducted", "under", "widely", "varying", "conditions", ",", "adverse", "reaction", "rates", "observed", "in", "the", "clinical", "trials", "of", "a", "drug", "can", "not", "be", "directly", "compared", "to", "rates", "...

[ [ 1, 2, "Study design" ], [ 16, 17, "Study design" ], [ 30, 31, "Study design" ], [ 63, 64, "Study design" ], [ 84, 85, "Study design" ], [ 274, 275, "Study design" ], [ 10, 12, "Outcome measure" ], [ ...

[ "The", "active", "ingredient", "in", "Famotidine", "Injection", "is", "a", "histamine", "H2", "-", "receptor", "antagonist", ".", "Famotidine", "is", "N'-(aminosulfonyl)-3-[[[2-[(diaminomethylene)amino]-4", "-", "thiazolyl]methyl]thio]propanimidamide", ".", "The", "empirica...

[ [ 4, 5, "Drug product" ], [ 76, 77, "Drug product" ], [ 8, 12, "Drug class" ], [ 16, 18, "Chemical name" ], [ 26, 26, "Empirical formula" ], [ 32, 32, "Molecular weight" ], [ 43, 48, "Physical description" ...

[ "The", "present", "invention", "provides", "a", "membrane", "the", "conductivity", "of", "which", "is", "dependent", "on", "the", "presence", "or", "absence", "of", "an", "analyte", ".", " ", "The", "membrane", "comprises", "a", "closely", "packed", "array", ...

[ [ 5, 5, "Device" ], [ 23, 23, "Device" ], [ 85, 85, "Device" ], [ 128, 128, "Device" ], [ 206, 206, "Device" ], [ 236, 236, "Device" ], [ 272, 272, "Device" ], [ 7, 7, "Property" ], [ ...

[ "INTRODUCTION", ":", "Women", "with", "a", "prior", "stillbirth", "or", "a", "history", "of", "recurrent", "first", "trimester", "miscarriages", "are", "at", "increased", "risk", "of", "adverse", "pregnancy", "outcomes", ".", "However", ",", "little", "is", "k...

[ [ 2, 6, "Patient group" ], [ 9, 14, "Medical history" ], [ 20, 22, "Outcome" ], [ 67, 69, "Outcome" ], [ 34, 37, "Event" ], [ 39, 41, "Outcome" ], [ 77, 78, "Study type" ], [ 80, 81, "Study ty...

[ "&", "lt;P>PROBLEM", "TO", "BE", "SOLVED", ":", "To", "provide", "an", "implantable", "device", "which", "can", "convey", "a", "therapeutic", "agent", "to", "tissue", "or", "organs", "for", "a", "long", "period", "of", "time", ".", " ", "&", "lt;P>SO...

[ [ 9, 10, "Device" ], [ 15, 16, "Substance" ], [ 82, 83, "Substance" ], [ 18, 18, "Organ" ], [ 106, 106, "Organ" ], [ 20, 20, "Organ" ], [ 36, 36, "Shape" ], [ 56, 56, "Shape" ], [ 91, ...

[ "BACKGROUND", ":", "Iran", "is", "facing", "an", "epidemiological", "transition", "with", "the", "increasing", "burden", "of", "non", "-", "communicable", "diseases", ",", "such", "as", "obesity", "-", "related", "disorders", "and", "cardiovascular", "diseases", ...

[ [ 2, 2, "Country" ], [ 85, 85, "Country" ], [ 373, 373, "Country" ], [ 13, 16, "Disease category" ], [ 367, 370, "Disease category" ], [ 20, 23, "Disease category" ], [ 25, 29, "Disease category" ], [ ...

[ "A", "medical", "information", "system", ".", "In", "one", "embodiment", ",", "the", "medical", "information", "system", "includes", ":", "a", "learning", "engine", ";", "a", "user", "interface", "in", "communication", "with", "the", "learning", "engine", ";",...

[ [ 1, 3, "System" ], [ 10, 12, "System" ], [ 16, 17, "Component" ], [ 26, 27, "Component" ], [ 37, 38, "Component" ], [ 42, 43, "Component" ], [ 91, 92, "Component" ], [ 20, 21, "Component" ]...

[ "In", "spring", "2020", "four", "regions", "of", "France", "faced", "a", "surge", "of", "severe", "Coronavirus", "(", "COVID", ")", "patients", "which", "threatened", "to", "overflow", "local", "intensive", "care", "units", "(", "ICU", ")", "capacities", "."...

[ [ 6, 6, "Country" ], [ 1, 2, "Time period" ], [ 12, 16, "Patient group" ], [ 22, 28, "Medical facility" ], [ 36, 38, "Time period" ], [ 42, 43, "Patient group" ], [ 66, 69, "Medical procedure" ], [ 72...

[ "Endophytic", "bacterium", "Serratia", "plymuthica", "A30", "was", "identified", "as", "a", "superior", "biocontrol", "agent", "due", "to", "its", "effective", "colonization", "of", "potato", "tuber", ",", "tolerance", "to", "cold", "conditions", ",", "and", "st...

[ [ 2, 4, "Bacterium" ], [ 18, 19, "Plant part" ], [ 23, 24, "Environmental factor" ], [ 37, 38, "Pathogen" ], [ 42, 43, "Biological process" ], [ 70, 71, "Time period" ], [ 176, 177, "Time period" ], [ ...

[ "The", "invention", "relates", "to", "a", "traditional", "Chinese", "medicine", "composition", "for", "treating", "functional", "constipation", "and", "application", "thereof", ",", "wherein", "the", "traditional", "Chinese", "medicine", "composition", "is", "prepared...

[ [ 5, 8, "Drug" ], [ 19, 22, "Drug" ], [ 140, 143, "Drug" ], [ 170, 173, "Drug" ], [ 227, 230, "Drug" ], [ 11, 12, "Condition" ], [ 73, 74, "Condition" ], [ 146, 147, "Condition" ], [ 2...

[ "ProAmatine", "®", "is", "indicated", "for", "the", "treatment", "of", "symptomatic", "orthostatic", "hypotension", "(", "OH", ")", ".", "Because", "ProAmatine", "®", "can", "cause", "marked", "elevation", "of", "supine", "blood", "pressure", "(", "BP>200", "m...

[ [ 0, 0, "Drug" ], [ 16, 16, "Drug" ], [ 72, 72, "Drug" ], [ 107, 107, "Drug" ], [ 136, 136, "Drug" ], [ 145, 145, "Drug" ], [ 8, 13, "Condition" ], [ 23, 25, "Measurement" ], [ 44, ...

[ "Our", "federally", "qualified", "health", "care", "center", "serves", "over", "7000", "diabetic", "patients", ",", "many", "of", "whom", "are", "uninsured", "(", "43", "%", ")", "or", "on", "medicaid", "(", "18", "%", ")", "or", "medicare", "(", "26", ...

[ [ 1, 5, "Healthcare facility" ], [ 9, 10, "Patient group" ], [ 16, 16, "Insurance status" ], [ 23, 23, "Insurance program" ], [ 29, 29, "Insurance program" ], [ 40, 40, "Ethnicity" ], [ 44, 44, "Ethnicity" ...

[ "As", "with", "other", "NSAIDs", ",", "anaphylactic", "/", "anaphylactoid", "reactions", "may", "occur", "in", "patients", "without", "known", "prior", "exposure", "to", "indomethacin", ".", "Indomethacin", "should", "not", "be", "given", "to", "patients", "with...

[ [ 5, 8, "Adverse drug event" ], [ 18, 18, "Drug" ], [ 20, 20, "Drug" ], [ 97, 97, "Drug" ], [ 186, 186, "Drug" ], [ 229, 229, "Drug" ], [ 246, 246, "Drug" ], [ 301, 301, "Drug" ], [ 33...

[ "1,051,461", ".", "Topical", "compositions", "comprising", "fatty", "amines", ".", "GILLETTE", "CO", ".", "Oct.", "28", ",", "1964", ".", "[", "Nov.", "4", ",", "1963", "]", ",", "No", ".", "43965/64", ".", "Heading", "A5B.", "[", "Also", "in", "Divisi...

[ [ 2, 3, "Composition" ], [ 5, 6, "Component" ], [ 8, 9, "Assignee" ], [ 11, 14, "Date" ], [ 17, 20, "Date" ], [ 23, 25, "Patent number" ], [ 32, 35, "Classification" ], [ 56, 57, "Component" ...

[ "A", "prospective", "imaging", "ancillary", "study", "coincides", "with", "recruitment", "of", "ICTuS", "2", "by", "using", "currently", "available", "imaging", "tools", "at", "a", "subset", "of", "multicenter", "sites", ".", "HASTIER", "will", "evaluate", "ther...

[ [ 9, 10, "Clinical trial" ], [ 24, 24, "Study" ], [ 15, 16, "Medical device" ], [ 21, 22, "Research location" ], [ 27, 28, "Outcome measure" ], [ 30, 32, "Outcome measure" ], [ 34, 34, "Medical procedure" ]...

[ "Flavored", "dosage", "forms", ",", "e.g.", ",", "lozenges", "and", "gums", ",", "are", "provided", "for", "sustained", "release", "of", "a", "flavoring", "agent", "in", "the", "mouth", ".", "The", "dosage", "forms", "provide", "sustained", "release", "by", ...

[ [ 0, 2, "Drug product" ], [ 6, 6, "Dosage form" ], [ 128, 128, "Dosage form" ], [ 150, 150, "Dosage form" ], [ 8, 8, "Dosage form" ], [ 162, 162, "Dosage form" ], [ 17, 18, "Active pharmaceutical ingredient" ...

[ "Hypertension", ":", "The", "adult", "starting", "indapamide", "dose", "for", "hypertension", "is", "1.25", "mg", "as", "a", "single", "daily", "dose", "taken", "in", "the", "morning", ".", "If", "the", "response", "to", "1.25", "mg", "is", "not", "satisfa...

[ [ 0, 0, "Condition" ], [ 8, 8, "Condition" ], [ 5, 5, "Drug" ], [ 92, 92, "Drug" ], [ 145, 145, "Drug" ], [ 149, 149, "Drug" ], [ 10, 11, "Dosage" ], [ 26, 27, "Dosage" ], [ 14, 16...

[ "&", "lt;P>PROBLEM", "TO", "BE", "SOLVED", ":", "To", "provide", "an", "effective", "and", "safe", "anti", "-", "viral", "agent", "capable", "of", "being", "applied", "to", "fields", "such", "as", "medicines", ",", "cosmetics", ",", "foods", ",", "clean...

[ [ 12, 15, "Substance" ], [ 61, 61, "Substance" ], [ 80, 80, "Substance" ], [ 85, 85, "Substance" ], [ 64, 72, "Property" ], [ 84, 85, "Substance" ], [ 24, 24, "Field of application" ], [ 91, 91, ...

[ "This", "multi", "-", "center", "randomized", ",", "double", "-", "blind", ",", "placebo", "-", "controlled", "study", "will", "evaluate", "the", "safety", "of", "ABI", "-", "M201", "and", "its", "effects", "on", "disease", "activity", "measures", "in", "m...

[ [ 19, 21, "Drug" ], [ 133, 135, "Drug" ], [ 164, 166, "Drug" ], [ 45, 45, "Drug" ], [ 40, 40, "Condition" ], [ 10, 10, "Control" ], [ 137, 137, "Control" ], [ 168, 168, "Control" ], [ ...

[ "The", "recommended", "dosage", "range", "for", "FETZIMA", "is", "40", "mg", "to", "120", "mg", "once", "daily", ",", "with", "or", "without", "food", ".", "FETZIMA", "should", "be", "initiated", "at", "20", "mg", "once", "daily", "for", "2", "days", "...

[ [ 5, 5, "Drug" ], [ 20, 20, "Drug" ], [ 48, 48, "Drug" ], [ 77, 77, "Drug" ], [ 87, 87, "Drug" ], [ 7, 8, "Dosage" ], [ 36, 37, "Dosage" ], [ 55, 56, "Dosage" ], [ 10, 11, "Dos...

[ "Participants", "in", "this", "group", "will", "continue", "with", "their", "usual", "care", "for", "the", "first", "10", "weeks", "of", "the", "study", ".", "At", "week", "10", ",", "they", "will", "receive", "the", "same", "VIVA", "intervention", "." ]

[ [ 0, 0, "Study group" ], [ 8, 9, "Intervention" ], [ 12, 14, "Time period" ], [ 28, 29, "Intervention" ], [ 20, 21, "Time point" ] ]

[ "Prolonged", "use", "of", "high", "doses", "of", "orally", "active", "17", "-", "alpha", "-", "alkyl", "androgens", "(", "methyltestosterone", ")", "has", "been", "associated", "with", "serious", "hepatic", "adverse", "effects", "(", "peliosis", "hepatitis", "...

[ [ 8, 13, "Drug class" ], [ 15, 15, "Drug" ], [ 22, 24, "Adverse effects" ], [ 26, 27, "Adverse effect" ], [ 39, 40, "Adverse effect" ], [ 29, 30, "Adverse effect" ], [ 32, 33, "Adverse effect" ], [ 36...

[ "Two", "sterile", "gauzes", "will", "be", "dampen", "with", "the", "content", "of", "the", "second", "syringe", "(", "the", "content", "of", "the", "first", "syringe", "is", "always", "20", "ml", "of", "saline", "solution", "and", "it", "is", "the", "fir...

[ [ 1, 2, "Medical supply" ], [ 32, 33, "Medical supply" ], [ 11, 12, "Medical device" ], [ 69, 70, "Medical device" ], [ 22, 26, "Substance" ], [ 18, 19, "Medical device" ], [ 40, 45, "Substance" ], [ ...

[ "Matrix", "metalloproteinases", "(", "MMP", ")", "-2", "and", "-9", "belong", "to", "a", "multigene", "family", "of", "degradative", "enzymes", "implicated", "in", "the", "neoangiogenesis", "required", "for", "tumor", "growth", ".", "In", "the", "central", "ne...

[ [ 0, 7, "Biomarkers" ], [ 11, 12, "Gene family" ], [ 14, 15, "Enzymes" ], [ 19, 19, "Biological process" ], [ 22, 23, "Biological process" ], [ 27, 32, "Anatomical structure" ], [ 34, 34, "Biomarker" ], [...

[ "Breath", "testing", "utilizing", "13C", "is", "a", "safe", ",", "non", "-", "invasive", "means", "for", "measuring", "a", "certain", "pathway", "'s", "metabolic", "rate", ".", "13C", "is", "a", "stable", ",", "non", "-", "radioactive", "isotope", "which",...

[ [ 0, 1, "Medical test" ], [ 3, 3, "Isotope" ], [ 21, 21, "Isotope" ], [ 18, 19, "Measurement target" ], [ 24, 24, "Property of 13C" ], [ 26, 28, "Property of 13C" ], [ 40, 41, "Substance used in testing" ],...

[ "Idiopathic", "pulmonary", "fibrosis", "(", "IPF", ")", "is", "a", "scarring", "lung", "disease", ".", "It", "damages", "the", "air", "sacs", "that", "allow", "oxygen", "to", "be", "transferred", "into", "the", "blood", "and", "transported", "to", "vital", ...

[ [ 0, 5, "Disease" ], [ 9, 10, "Disease" ], [ 15, 16, "Anatomical structure" ], [ 19, 19, "Substance" ], [ 25, 25, "Substance" ], [ 29, 30, "Anatomical structure" ], [ 38, 38, "Symptom" ], [ 51, 51...

[ "PURPOSE", ":", "To", "obtain", "the", "titled", "preparation", "comprising", "human", "interferon", "as", "an", "active", "ingredient", ".", "CONSTITUTION", ":", "A", "solution", "containing", "human", "interferon", "(", "h", "-", "IFN", ":", "h", "-", "IFN...

[ [ 8, 9, "Active ingredient" ], [ 20, 21, "Active ingredient" ], [ 23, 25, "Abbreviation" ], [ 27, 29, "Abbreviation" ], [ 44, 46, "Abbreviation" ], [ 50, 52, "Abbreviation" ], [ 69, 71, "Abbreviation" ], ...

[ "The", "tumour", "evolution", "model", "posits", "that", "malignant", "transformation", "is", "preceded", "by", "randomly", "distributed", "driver", "mutations", "in", "cancer", "genes", ",", "which", "cause", "clonal", "expansions", "in", "phenotypically", "normal"...

[ [ 1, 3, "Model" ], [ 6, 7, "Process" ], [ 13, 14, "Mutation" ], [ 16, 17, "Gene" ], [ 21, 22, "Process" ], [ 29, 30, "Process" ], [ 107, 108, "Process" ], [ 152, 153, "Process" ], [ 26...

[ "A", "surgical", "resection", "is", "currently", "the", "preferred", "treatment", "for", "esophageal", "cancer", "if", "the", "tumor", "is", "considered", "to", "be", "resectable", "without", "evidence", "of", "distant", "metastases", ".", "A", "higher", "percen...

[ [ 9, 10, "Disease" ], [ 1, 2, "Treatment" ], [ 13, 13, "Condition" ], [ 36, 37, "Treatment" ], [ 46, 47, "Treatment" ], [ 53, 54, "Treatment" ], [ 141, 142, "Treatment" ], [ 58, 58, "Drug" ]...

[ "The", "participants", "will", "receive", "a", "link", "to", "the", "baseline", "survey", "at", "www.surveymonkey.com", ".", "After", "completing", "the", "survey", ",", "the", "participants", "will", "be", "randomized", "into", "an", "intervention", "or", "a", ...

[ [ 1, 1, "Study subjects" ], [ 19, 19, "Study subjects" ], [ 68, 68, "Study subjects" ], [ 83, 83, "Study subjects" ], [ 131, 131, "Study subjects" ], [ 152, 152, "Study subjects" ], [ 178, 178, "Study subject...

[ "All", "patients", "with", "active", "ulcerative", "colitis", "who", "present", "to", "the", "Outpatient", "department", "or", "the", "emergency", "services", "of", "PGIMER", "shall", "be", "screened", ".", "Those", "patients", "who", "have", "acute", "severe", ...

[ [ 4, 5, "Condition" ], [ 28, 29, "Condition" ], [ 10, 11, "Location" ], [ 14, 15, "Location" ], [ 17, 17, "Location" ], [ 26, 29, "Condition" ], [ 43, 44, "Criteria" ], [ 53, 54, "Study group"...

[ "Methylene", "Blue", "100", "mg", "capsules", ".", "Patients", "will", "receive", "Methylene", "blue", "(", "MB", ")", "capsules", "of", "100", "mg", "every", "12", "hours", "for", "a", "total", "of", "5", "days", "." ]

[ [ 0, 1, "Drug" ], [ 9, 10, "Drug" ], [ 2, 3, "Dosage" ], [ 4, 4, "Formulation" ], [ 14, 14, "Formulation" ], [ 18, 20, "Frequency" ], [ 25, 26, "Duration" ] ]

[ "The", "employment", "of", "machine", "learning", "approaches", "has", "shown", "promising", "results", "in", "predicting", "cancer", ".", "In", "the", "current", "study", ",", "polymorphisms", "data", "of", "five", "single", "nucleotide", "polymorphisms", "(", ...

[ [ 3, 4, "Approach" ], [ 12, 12, "Condition" ], [ 81, 81, "Condition" ], [ 92, 92, "Condition" ], [ 175, 175, "Condition" ], [ 19, 20, "Data type" ], [ 23, 33, "Genetic marker" ], [ 35, 36, "Ge...

[ "A", "method", "for", "analyzing", "an", "electrocardiography", "(", "ECG", ")", "signal", "is", "provided", ".", "The", "ECG", "signal", "is", "measured", "through", "a", "sensor", ".", "One", "or", "more", "specified", "waveforms", "in", "the", "ECG", "s...

[ [ 1, 1, "Patent component" ], [ 3, 3, "Action" ], [ 5, 9, "Signal" ], [ 20, 20, "Device" ], [ 25, 26, "Signal component" ], [ 35, 36, "Signal characteristic" ], [ 45, 46, "Signal characteristic" ], [ ...

[ "INTRODUCTION", ":", "The", "lateral", "antebrachial", "cutaneous", "nerve", "(", "LACN", ")", "is", "a", "somatosensory", "nerve", "coursing", "in", "the", "lateral", "portion", "of", "the", "forearm", ".", "The", "nerve", "is", "located", "in", "a", "close...

[ [ 3, 9, "Anatomical Structure" ], [ 12, 13, "Nerve Type" ], [ 21, 21, "Body Part" ], [ 71, 71, "Body Part" ], [ 33, 37, "Blood Vessel" ], [ 49, 49, "Medical Procedure" ], [ 336, 336, "Medical Procedure" ], ...

[ "Despite", "therapeutic", "advancements", ",", "cervical", "cancer", "caused", "by", "high", "-", "risk", "subtypes", "of", "the", "human", "papillomavirus", "(", "HPV", ")", "remains", "a", "leading", "cause", "of", "cancer", "-", "related", "deaths", "among"...

[ [ 4, 5, "Disease" ], [ 45, 46, "Plant" ], [ 52, 53, "Protein" ], [ 175, 176, "Protein" ], [ 290, 291, "Protein" ], [ 142, 142, "Compound" ], [ 163, 163, "Compound" ], [ 165, 165, "Compound" ...

[ "PURPOSE", ":", "To", "display", "retrieved", "check", "data", "in", "an", "optimum", "form", "by", "showing", "the", "attributes", "of", "the", "check", "data", "in", "a", "matrix", "of", "checking", "time", "points", "and", "checking", "items", "and", "v...

[ [ 5, 6, "Data" ], [ 17, 18, "Data" ], [ 14, 14, "Characteristics" ], [ 21, 21, "Data structure" ], [ 42, 42, "Data structure" ], [ 71, 71, "Data structure" ], [ 23, 25, "Time points" ], [ 27, 28, ...

[ "PURPOSE", ":", "A", "composition", "containing", "soybean", "fermentation", "is", "provided", "to", "ensure", "antibacterial", "effect", "and", "prevent", "and", "treat", "food", "poisoning", ".", "CONSTITUTION", ":", "A", "composition", "for", "preventing", "and...

[ [ 3, 3, "Entity" ], [ 23, 23, "Entity" ], [ 91, 91, "Entity" ], [ 5, 6, "Entity" ], [ 31, 32, "Entity" ], [ 39, 40, "Entity" ], [ 11, 12, "Effect" ], [ 17, 18, "Condition" ], [ 28, ...

[ "Commercially", "-", "available", "tomato", "food", "product", ":", "men", "in", "this", "group", "consumed", "V8", "®", "juice", "(", "11", "-", "16.5", "fl", ".", "oz./day", ")", "." ]

[ [ 0, 5, "Intervention" ], [ 7, 7, "Study group" ], [ 12, 14, "Intervention" ], [ 16, 21, "Dosage" ] ]

[ "Symptoms", "and", "Signs", "\n\n", "Symptoms", "following", "acute", "NSAIDs", "overdoses", "are", "usually", "limited", "to", "lethargy", ",", "drowsiness", ",", "nausea", ",", "vomiting", ",", "and", "epigastric", "pain", ",", "which", "are", "generally", "...

[ [ 7, 7, "Drug class" ], [ 64, 64, "Drug class" ], [ 87, 87, "Drug class" ], [ 13, 13, "Symptom" ], [ 15, 15, "Symptom" ], [ 17, 17, "Symptom" ], [ 187, 187, "Symptom" ], [ 19, 19, "Symptom" ...

[ "ASMANEX", "HFA", "is", "a", "metered", "dose", "inhaler", "for", "oral", "inhalation", "only", ",", "consisting", "of", "50", "mcg", ",", "100", "mcg", ",", "or", "200", "mcg", "of", "mometasone", "furoate", "per", "actuation", ".", "\n\n", "Mometasone", ...

[ [ 0, 1, "Drug product" ], [ 37, 38, "Drug product" ], [ 109, 110, "Drug product" ], [ 233, 234, "Drug product" ], [ 249, 250, "Drug product" ], [ 24, 25, "Active ingredient" ], [ 30, 31, "Active ingredient" ...

[ "Patients", "undergo", "collection", "of", "blood", "and", "urine", "samples", "on", "day", "1", ".", "Patients", "also", "undergo", "clinical", "assessments", ",", "laboratory", ",", "radiographic", ",", "and", "other", "ancillary", "studies", "on", "day", "1...

[ [ 0, 0, "Entity" ], [ 12, 12, "Entity" ], [ 6, 7, "Sample" ], [ 9, 10, "Time point" ], [ 27, 28, "Time point" ], [ 15, 16, "Procedure" ], [ 24, 25, "Procedure" ] ]

[ "Dexmedetomidine", "is", "a", "potent", "selective", "α-2", "-", "adrenergic", "receptor", "agonist", "frequently", "used", "for", "sedation", "in", "the", "ICU", ",", "also", "among", "critically", "ill", "patients", ".", "It", "promotes", "sedation", ",", "a...

[ [ 0, 0, "Drug" ], [ 16, 16, "Medical setting" ], [ 47, 47, "Medical setting" ], [ 13, 13, "Effect" ], [ 26, 26, "Effect" ], [ 28, 28, "Effect" ], [ 32, 32, "Effect" ], [ 35, 36, "Effect" ], ...

[ "The", "present", "invention", "relates", "to", ":", "a", "novel", "bacteriophage", "EC14", "having", "unique", "extinction", "capacity", "to", "a", "pathogenic", "colon", "bacillus", ",", "specifically", ",", "an", "enterotoxigenic", "E.", "coli", "(", "ETEC", ...

[ [ 8, 9, "Entity" ], [ 129, 130, "Entity" ], [ 166, 167, "Entity" ], [ 201, 202, "Entity" ], [ 228, 229, "Entity" ], [ 273, 274, "Entity" ], [ 16, 18, "Entity" ], [ 43, 45, "Entity" ], [ ...

[ "Investigators", "developed", "a", "brief", "standardized", "and", "manualized", "internet", "-", "delivered", "cognitive", "-", "behavioral", "(", "iCBT", ")", "program", "for", "treating", "anxious", "and", "depressive", "symptoms", "in", "children", "and", "ado...

[ [ 0, 0, "Researcher" ], [ 7, 16, "Intervention" ], [ 19, 22, "Condition" ], [ 24, 26, "Population" ], [ 90, 92, "Population" ], [ 31, 32, "Event" ], [ 34, 34, "Location" ], [ 41, 41, "Healthca...

[ "Over", "150,000", "soldiers", "are", "currently", "deployed", "in", "Iraq", "as", "part", "of", "Operation", "Iraqi", "Freedom", "(", "OIF", ")", ",", "and", "12", "%", "of", "returning", "OIF", "veterans", "have", "posttraumatic", "stress", "disorder", "("...

[ [ 11, 16, "Military operation" ], [ 7, 7, "Location" ], [ 339, 339, "Location" ], [ 454, 454, "Location" ], [ 488, 488, "Location" ], [ 26, 31, "Condition" ], [ 40, 41, "Military conflict" ], [ 49, ...

[ "This", "group", "is", "composed", "by", "20", "ALS", "subjects", "under", "600", "mg", "valproate", "and", "600", "mg", "of", "litium", "carbonate", "per", "day", ",", "during", "21", "months", ".", "The", "tablets", "are", "given", "orally", "with", "m...

[ [ 6, 7, "Patient group" ], [ 9, 11, "Drug dosage" ], [ 13, 17, "Drug dosage" ], [ 22, 23, "Duration" ], [ 26, 26, "Drug form" ], [ 29, 29, "Administration route" ], [ 30, 31, "Administration condition" ] ]

[ "Tramadol", "hydrochloride", "tablets", ",", "USP", "are", "an", "opioid", "agonist", ".", "The", "chemical", "name", "for", "tramadol", "hydrochloride", "is", "(", "±", ")", "cis-2-[(dimethylamino)methyl]-1-(3", "-", "methoxyphenyl", ")", "cyclohexanol", "hydrochlo...

[ [ 0, 4, "Drug product" ], [ 7, 8, "Drug class" ], [ 17, 25, "Chemical name" ], [ 47, 54, "Physical description" ], [ 58, 63, "Solubility" ], [ 67, 69, "Acid-base property" ], [ 84, 87, "logP value" ], [ ...

[ "PURPOSE", ":", "To", "prepare", "an", "antibiotic", "composition", "preservable", "for", "a", "long", "period", ",", "by", "using", "a", "penicillanic", "acid", "salt", "in", "combination", "with", "an", "additive", "composed", "of", "cyclic", "monosaccharide",...

[ [ 5, 6, "Substance" ], [ 161, 162, "Substance" ], [ 16, 18, "Substance" ], [ 23, 23, "Substance" ], [ 64, 64, "Substance" ], [ 144, 144, "Substance" ], [ 26, 27, "Substance" ], [ 31, 32, "Subs...

[ "The", "acyl", "-", "β", "-", "glucuronide", "metabolite", "of", "clopidogrel", "is", "a", "strong", "inhibitor", "of", "CYP2C8", ".", "Clopidogrel", "can", "increase", "the", "systemic", "exposure", "to", "drugs", "that", "are", "primarily", "cleared", "by", ...

[ [ 8, 8, "Drug" ], [ 16, 16, "Drug" ], [ 44, 44, "Drug" ], [ 72, 72, "Drug" ], [ 105, 105, "Drug" ], [ 1, 6, "Metabolite" ], [ 14, 14, "Enzyme" ], [ 29, 29, "Enzyme" ], [ 46, 46, ...

[ "Participants", "will", "be", "advised", "to", "use", "a", "Probiotic", "toothpaste", "twice", "a", "day", "for", "3", "weeks", "after", "the", "bonding", ".", "A", "probiotic", "toothpaste", "and", "a", "standard", "brushing", "technique", "will", "be", "co...

[ [ 0, 0, "Study subject" ], [ 33, 33, "Study subject" ], [ 7, 8, "Intervention" ], [ 20, 21, "Intervention" ], [ 24, 26, "Intervention" ], [ 17, 17, "Procedure" ] ]

[ "Although", "cognitive", "-", "behavioral", "therapy", "(", "CBT", ")", "is", "the", "most", "effective", "intervention", "for", "pediatric", "obsessive", "-", "compulsive", "disorder", "(", "OCD", ")", ",", "many", "people", "do", "receive", "CBT", "initially...

[ [ 1, 7, "Intervention" ], [ 14, 21, "Condition" ], [ 61, 62, "Treatment" ], [ 74, 75, "Treatment" ], [ 143, 148, "Intervention" ], [ 157, 158, "Study population" ], [ 165, 167, "Intervention arm" ], [ ...

[ "There", "is", "no", "known", "antidote", "for", "overdoses", "of", "lapatinib", "tablets", ".", "The", "maximum", "oral", "doses", "of", "lapatinib", "that", "have", "been", "administered", "in", "clinical", "trials", "are", "1,800", "mg", "once", "daily", ...

[ [ 8, 9, "Drug" ], [ 34, 35, "Drug" ], [ 179, 180, "Drug" ], [ 6, 6, "Condition" ], [ 22, 23, "Study" ], [ 45, 46, "Study" ], [ 25, 28, "Dosage" ], [ 51, 52, "Risk" ], [ 56, 57, ...

[ "Adults", "\n\n", "Adult", "surgical", "patients", "receiving", "general", "balanced", "anesthesia", "(", "barbiturate", ":", "thiopental", ",", "methohexital", ",", "or", "thiamylal", ";", "opioid", ":", "alfentanil", "or", "fentanyl", ";", "nitrous", "oxide", ...

[ [ 0, 0, "Patient group" ], [ 134, 134, "Patient group" ], [ 3, 4, "Patient subgroup" ], [ 6, 8, "Anesthesia type" ], [ 12, 12, "Drug" ], [ 14, 14, "Drug" ], [ 17, 17, "Drug" ], [ 21, 21, "Drug...