Unnamed: 0 int64 0 1.1k | MICROBE stringlengths 2 45 | DISEASE stringlengths 2 53 | EVIDENCE stringlengths 58 610 | RELATION stringclasses 4
values | QUESTIONS stringlengths 44 112 |
|---|---|---|---|---|---|
1,000 | Bacteroides vulgatus | ASD | (b) A lower abundance of the usually highly abundant Bacteroides vulgatus is significantly correlated with lower levels of d-glutamine and d-glutamate metabolic pathways in the guts of ASD children. | negative | What is the relationship between Bacteroides vulgatus and ASD? |
1,001 | NTHi | mucosal epithelium | Another virulence factor that has been reported by Murphy and co-workers to play a pivotal role for NTHi survival in COPD settings is IgA-protease, a hydrolytic enzyme that cleaves secretory IgA (sIgA) antibodies in the mucosal epithelium (226?228). | na | What is the relationship between NTHi and mucosal epithelium? |
1,002 | Lactobacillus | AD | [96] on 27 AD patients and 6 healthy controls, the bacterial EV composition differs significantly between the two groups evaluated, with a marked reduction of Lactococcus, Leuconostoc, and Lactobacillus EV proportions and an increase of those from Alicyclobacillus and Propionibacterium in AD patients with respect to co... | negative | What is the relationship between Lactobacillus and AD? |
1,003 | Porphyromonas endodontalis | gingivitis | Approximately 46% of the assigned OTUs were more abundant in diseased individuals (particularly in patients with gingivitis), while few classified OTUs were predominant in samples from PH individuals, including known oral pathogens such as Porphyromonas endodontalis and Prevotella tannerae. | na | What is the relationship between Porphyromonas endodontalis and gingivitis? |
1,004 | Clostridium | necrotic enteritis | Dietary supplementation of chickens with virginiamycin decreased intestinal colonization by Clostridium perfringens35, and decreased the severity and mortality due to necrotic enteritis caused by C. perfringens36, both compared with unsupplemented controls. | positive | What is the relationship between Clostridium and necrotic enteritis? |
1,005 | Clostridium | ASD | A reduced capacity for nutrient digestion and transport in children with ASD has been related to increased levels of Clostridium species, Bacteriodetes depletion, and loss of metabolites related to energy homeostastis (e.g disaccharidases, hexose transporters) (Williams et?al., 2011). | positive | What is the relationship between Clostridium and ASD? |
1,006 | Prevotella copri | CRC | The most significantly overrepresented species in normal samples compared to CRC samples were Prevotella copri, Prevotella stercorea, and Faecalibacterium prausnitzii, while for the CRC samples we found that Collinsella aerofaciens (Actinobacteria), [Eubacterium] biforme (Firmicutes), Oxalobacter formigenes (Proteobact... | negative | What is the relationship between Prevotella copri and CRC? |
1,007 | Porphyromonas gingivalis | diabetes mellitus | (25) described the association of Porphyromonas gingivalis and Porphyromonas endodontalis isolated in samples from root canals with necrotic pulp and a history of diabetes mellitus (OR > 2), but the sample was too small to establish any definitive association. | positive | What is the relationship between Porphyromonas gingivalis and diabetes mellitus? |
1,008 | Pseudomonas aeruginosa | cystic fibrosis | Pseudomonas aeruginosa is a Gram-negative, versatile, opportunistic pathogen that causes chronic lung infections in cystic fibrosis (CF) patients. | positive | What is the relationship between Pseudomonas aeruginosa and cystic fibrosis? |
1,009 | Eggerthella lenta | DM | Interestingly, Eggerthella lenta, which was not detected in the DM cohort, was found in the DM+HT cohort. | na | What is the relationship between Eggerthella lenta and DM? |
1,010 | CD | CDI | Consequently, in vitro models lacking host factors may only provide partial understanding of the CD colonization mechanisms involved with CDI. | relate | What is the relationship between CD and CDI? |
1,011 | Neisseria flavescens | OSCC | Despite significant inter-individual variation, 14 species were detected across all samples, including Actinomyces odontolyticus, Prevotella melaninogenica, Prevotella scopos, Capnocytophaga gingivalis, Gemella sanguinis, Granulicatella adiacens, Streptococcus oralis, Streptococcus salivarius, Lachnoanaerobaculum umeae... | positive | What is the relationship between Neisseria flavescens and OSCC? |
1,012 | Fusobacterium | pancreatic cancers | Detection of Fusobacterium species in cancer tissue specimens of pancreatic cancer We assessed 302 formalin-fixed, paraffin-embedded (FFPE) tissue specimens of pancreatic cancers using the TaqMan Gene Expression Assay for Fusobacterium species and obtained 283 (94%) positive results. | positive | What is the relationship between Fusobacterium and pancreatic cancers? |
1,013 | Fusobacterium nucleatum | colitis | On the other hand, Fusobacterium nucleatum does not exacerbate colitis, enteritis, or inflammation- associated intestinal carcinogenesis, which is contrary to the role of other colon cancer-associated bacteria [71]. | negative | What is the relationship between Fusobacterium nucleatum and colitis? |
1,014 | Escherichia | osteoporosis | In contrast, the abundances of members of the Enterobacteriaceae and Pseudomonadaceae families, such as Enterobacter, Klebsiella, Escherichia/Shigella, Citrobacter, Pseudomonas, Succinivibrio and Desulfovibrio, were enriched in the osteopenia and osteoporosis groups. | positive | What is the relationship between Escherichia and osteoporosis? |
1,015 | Fusobacterium | UUI | The abundance of Fusobacterium was lower in the EDM group, although it has previously been shown to increase in patients with UUI [37]. | positive | What is the relationship between Fusobacterium and UUI? |
1,016 | Fusobacterium | colorectal adenomas | This was the first Portuguese study using this method to determine the Fusobacterium spp load in both colorectal adenomas or carcinomas and paired normal tissue, making it possible to measure total and specific bacterial DNA copies in the very same reaction with clear cost-effective advantages for the clinical setting. | relate | What is the relationship between Fusobacterium and colorectal adenomas? |
1,017 | Clostridium perfringens | intestinal adenoma | High DCA concentrations (>1?mmol/L) inhibit the growth of many intestinal bacteria, including Clostridium perfringens, Bacteroides fragilis, lactobacilli, and bifidobacteria in vitro.32 Thus, it is reasonable to consider that the interaction between bile acids and the gut microbiota controls the progression of intestin... | relate | What is the relationship between Clostridium perfringens and intestinal adenoma? |
1,018 | Roseburia inulinivorans | CD | At the species level, a considerable reduction of butyrate-producing bacterial species, as Blautia faecis, Roseburia inulinivorans, Ruminococcus torques, Clostridium lavalense, Bacteroides uniformis, and F. prausnitzii characterized CD patients respect to healthy subjects. | positive | What is the relationship between Roseburia inulinivorans and CD? |
1,019 | Ruminococcus | atherosclerosis | In studies of other cohorts, less clear dominance of the genus Ruminococcus and stronger clustering around the genera Bacteroides and Prevotella have been found, yet both long-term diet and disease (atherosclerosis) have been linked to these enterotypes. | relate | What is the relationship between Ruminococcus and atherosclerosis? |
1,020 | Dialister invisus | IBD | The genera Acinetobacter and Bacteroides are increased significantly in IBD patients during the active phase (Andoh et al., 2012; Tang et al., 2015), though a massive amount of Dialister invisus has been identified in the state of inactivity or dormancy in the gut of patients with IBD (Schirmer et al., 2018). | negative | What is the relationship between Dialister invisus and IBD? |
1,021 | Streptococcus | periodontitis | The healthy group dominated by Streptococcus sp., the gingivitis group was composed mostly by the genera Streptococcus, Capnocytophaga, Haemophilus, and Leptotrichia and the periodontitis group with a high abundance of Porphyromonas. | relate | What is the relationship between Streptococcus and periodontitis? |
1,022 | Bacteroides thetaiotaomicron | tumor | Furthermore, at the species level, we also found that Alistipes shahii (Figure 6G), Akkermansia muciniphila (Figure 6H), Bacteroides thetaiotaomicron (Figure 6I), Bacteroides acidifaciens and Lactobacillus johnsonii (Figure S5) were increased in EcN-respond mice compared with tumor bearing controls. | na | What is the relationship between Bacteroides thetaiotaomicron and tumor? |
1,023 | Bacteroides dorei | PD | Interestingly we have identified (with databank RDP v11.4) an increase in Akkermansia muciniphila and Bacteroides dorei in PD groups compared to HD and ND groups (Figure 6C). | positive | What is the relationship between Bacteroides dorei and PD? |
1,024 | Mycobacterium avium | CD | With CD in particular, individual species such as Mycobacterium avium subspecies paratuberculosis or Escherichia coli have been implicated in disease aetiology [20,21] while the emerging "dysbiosis" hypothesis implicates multi-species assemblages in an overall imbalance between harmful and protective bacteria [22,23]. | relate | What is the relationship between Mycobacterium avium and CD? |
1,025 | Fusobacterium | gastric cancer | Recent studies showed that Fusobacterium species are detected in gastrointestinal tract cancers, such as gastric cancer [34] and colorectal cancer [26, 29, 30]; however, published studies have not examined the relationship of Fusobacterium species with the cancer outcome in a large sample (n > 100) of such patients. | relate | What is the relationship between Fusobacterium and gastric cancer? |
1,026 | Actinomyces neuii | UUI | Also, Actinobaculum schaalii, Actinomyces neuii, Aerococcus urinae, Arthrobacter cumminsii, Corynebacterium coyleae, Gardnerella vaginalis, Oligella urethralis, and Streptococcus anginosus were more frequently isolated from UUI women (see Table?S2 in the supplemental material). | positive | What is the relationship between Actinomyces neuii and UUI? |
1,027 | Streptococcus | PSC | At the species level, seven taxa belonging to genera Rothia, Lactobacillus, Streptococcus and Veillonella, were overrepresented, specifically in PSC patients, compared with both HCs and patients with UC (Table 3). | positive | What is the relationship between Streptococcus and PSC? |
1,028 | Fusobacterium | pancreatic cancer | Although neither CIMP status nor MLH1 methylation correlate with tumor Fusobacterium species status, our results show that the CIMP-high status is associated with an unfavorable prognosis of pancreatic cancer. | na | What is the relationship between Fusobacterium and pancreatic cancer? |
1,029 | EAEC | diarrhea | It is worth noting, however, that the association between bacterial pathogens and RV1 response was contingent on the exclusion of EAEC, which we omitted from primary comparisons because of its high prevalence and limited association with diarrhea during previous studies in resource-poor settings using TACs. | na | What is the relationship between EAEC and diarrhea? |
1,030 | Escherichia | UC | A marginal inverse correlation between Escherichia phage and Escherichia genus bacteria in UC mucosa was observed (figure 7B). | negative | What is the relationship between Escherichia and UC? |
1,031 | Yersinia enterocolitica | IBD | [2] showed that individual T cell clones from IBD patients were reactive to Bacteroides thetaiotaomicron, Bifidobacterium bifidum, Escherichia coli, and Yersinia enterocolitica. | relate | What is the relationship between Yersinia enterocolitica and IBD? |
1,032 | Streptococcus salivarius | IBD | Two facultative anaerobes showed increased abundance in IBD patients (Streptococcus salivarius and Streptococcus parasanguinis), whereas six anaerobes showed decreased abundance in the IBD samples (including Blautia obeum and Alistipes putredinis; Additional file 3: Table S3). | positive | What is the relationship between Streptococcus salivarius and IBD? |
1,033 | Fn | CRC | These findings not only suggest the immense potential of Fn as a clinically actionable biomarker for precise treatment in stage III/IV patients, but also provide a promising adjuvant therapeutic strategy for them that targeting Fn may be helpful for preventing CRC metastasis and improving chemotherapy efficacy. | negative | What is the relationship between Fn and CRC? |
1,034 | Desulfovibrio | nonalcoholic steatohepatitis | Xie et al.found that Desulfovibrio was markedly increased in STZ-HFD-induced nonalcoholic steatohepatitis and was positively correlated with LPS levels [53]. | positive | What is the relationship between Desulfovibrio and nonalcoholic steatohepatitis? |
1,035 | Klebsiella | colitis | In summary, our study demonstrates that cinobufacini could modulate the composition of the intestinal flora and restore the relative abundances of vital bacteria including Klebsiella, Proteus, Entrobacter and Bacteroides, preventing the imbalance of gut microbiota in DSS-induced colitis. | negative | What is the relationship between Klebsiella and colitis? |
1,036 | Enterococcus faecalis | colon cancer14 | Oxygen free radicals in the intestinal environment can have a negative influence on intestinal homeostasis; specifically, O2?? is reportedly produced in the colon of rats inoculated with a specific strain of Enterococcus faecalis, and this radical has been implicated in colon cancer14. | relate | What is the relationship between Enterococcus faecalis and colon cancer14? |
1,037 | enterococcus | pneumonia | Individually selected and cultured probiotic strains of lactobacillus or enterococcus were successfully tested in the clinic on patients with irritable bowel syndrome (IBS) and pneumonia (Suvorov, 2013). | relate | What is the relationship between enterococcus and pneumonia? |
1,038 | Citrobacter Koseri ATCC BAA-895 | colorectal cancer | Since different strains were available for these species, only strains described in human colorectal cancer and available in biocyc.org were chosen: Fusobcterium nucleatum animalis 11_3_2; Microbacterium testaceum 87StLB037; Slackia exgua ATCC 700122 and Citrobacter Koseri ATCC BAA-895. | relate | What is the relationship between Citrobacter Koseri ATCC BAA-895 and colorectal cancer? |
1,039 | Brucella | ASD | Furthermore, when the taxa abudance between ASD and DD children were compared, two taxa were elevated in children with ASD, Brucella (FDR?=?0.05) and Enterococcus faecalis OG1RF (FDR?=?0.05), while one taxa (Flavobacterium sp. | positive | What is the relationship between Brucella and ASD? |
1,040 | Mycobacterium avium | IBD | Species-level analysis also failed to identify any pathogenic species that have been previously associated with IBD such as Mycobacterium avium subspecies paratuberculosis, Yersinia spp or Listeria spp. | relate | What is the relationship between Mycobacterium avium and IBD? |
1,041 | Blautia coccoides | RA | No previous association of Blautia coccoides (which was depleted in our na?ve group) with RA was reported; nonetheless, it was shown that enriching the gut microbiota of systemic lupus erythematosus patients with Blautia coccoides, together with Ruminococcus obeum and Bifidobacterium bifidum, improved the inflammatory ... | relate | What is the relationship between Blautia coccoides and RA? |
1,042 | Streptococcus | CD | Similarly, Streptococcus and Fusicatenibacter were found in higher levels in MP than in CD and DU (p = 0.021?0.043). | relate | What is the relationship between Streptococcus and CD? |
1,043 | Klebsiella pneumoniae | gut dysbiosis | We found that the increased susceptibility to Klebsiella pneumoniae in alcohol-fed animals is, in part, mediated by gut dysbiosis, as alcohol-na?ve animals recolonized with a microbiota isolated from alcohol-fed mice had an increased K. pneumoniae burden compared to mice recolonized with a control microbiota. | relate | What is the relationship between Klebsiella pneumoniae and gut dysbiosis? |
1,044 | Veillonella | periodontitis | On the other side, Streptococcus, Prevotella, Veillonella and Fusobacterium are genera in which different species have been related to healthy and diseased conditions (caries, periodontitis, halitosis and even oral cancer) [21?25]. | relate | What is the relationship between Veillonella and periodontitis? |
1,045 | Enterococcus faecalis | gastric cancer | In the present study, the probiotic combination of Bifidobacterium infantis, Lactobacillus acidophilus, Enterococcus faecalis and Bacillus cereus was supplied to gastric cancer patients with partial gastrectomy, and their effect on reducing the severity of physiological disorders and microbial diversity in the stomach ... | relate | What is the relationship between Enterococcus faecalis and gastric cancer? |
1,046 | Ruminococcus | CD | To further support these claims, we also examined the anaerobic bacteria F. plautii and Ruminococcus sp., which display increased ICI in CD patients compared to non-IBD patients and were isolated live from our pediatric cohort. | relate | What is the relationship between Ruminococcus and CD? |
1,047 | GBS | maternal infection | Maternal UTI during pregnancy and maternal GBS captured using ICD-9-CM codes served as our indicator of maternal infection and antibiotic use during pregnancy. | relate | What is the relationship between GBS and maternal infection? |
1,048 | Salmonella enterica | advanced solid tumours | Additionally, a Salmonella enterica flagellin derivative (CBLB502), is under investigation for the treatment of patients with advanced solid tumours. | relate | What is the relationship between Salmonella enterica and advanced solid tumours? |
1,049 | Ruminococcus gnavus | CHD | Therefore, in this study, Ruminococcus gnavus might show different characteristics in two different diseases of CHD-NAFLD and CHD and further research was needed. | relate | What is the relationship between Ruminococcus gnavus and CHD? |
1,050 | Clostridium | atopic disease | Infants fed formula from ruminant milk, lacking fucosylated RMOs, display lower abundances of Lactobacilli and Bifidobacterium relative to increased abundances of Clostridium, Bacteroides, and members of the Enterobactereaceae family, which may result in a predisposition to colitis and atopic disease later in life [42]... | positive | What is the relationship between Clostridium and atopic disease? |
1,051 | S. pneumoniae | influenza A virus infection | Specifically, S. pneumoniae has been shown to establish a mutually beneficial relationship with the influenza virus, with studies suggesting that influenza A virus infection can enhance the transmission of S. pneumoniae.44,45 Wen et?al. | positive | What is the relationship between S. pneumoniae and influenza A virus infection? |
1,052 | Propionibacterium acnes | periodontitis | A few years before, in 2012, the same author, together with R??as (11), isolated Propionibacterium acnes (52% prevalence), as the most frequently present microorganism in cases of post-treatment apical periodontitis. | positive | What is the relationship between Propionibacterium acnes and periodontitis? |
1,053 | Citrobacter freundii | atrophic gastritis | False-positive results were observed in case of adult patients with acid-free stomach, caused by atrophic gastritis or a long-term use of PPIs, where urease-positive bacterial species such as Proteus mirabilis, Citrobacter freundii, Klebsiella pneumoniae, Staphylococcus aureus, and Enterobacter cloacae were cultured. | na | What is the relationship between Citrobacter freundii and atrophic gastritis? |
1,054 | Lactobacillus sakei | colitis | In this context, the administration of Lactobacillus sakei, a bacterium isolated from the traditional seed mash used for brewing sake, showed the capacity to ameliorate colon shortening and MPO activity, as well as the infiltration of antigen presenting cells (APC) into the colon in the TNBS-induced colitis model. | relate | What is the relationship between Lactobacillus sakei and colitis? |
1,055 | Proteus mirabilis | gastroduodenal infections | In fact, ureolytic activity has a key role in the pathogenesis of bacteria such as Clostridium perfringens, Helicobacter pylori, Klebsiella pneumoniae, Proteus mirabilis, Salmonella spp., Staphylococcus saprophyticus, Ureoplasma urealyticum, and Yersinia enterocolitica, and such activity has been reported in diseases s... | relate | What is the relationship between Proteus mirabilis and gastroduodenal infections? |
1,056 | Stenotrophomonas maltophilia | Clostridium botulinum | Accordingly, Acinetobacter baumannii, Clostridium botulinum, Escherichia coli, Pseudomonas aeruginosa, Ralstonia pickettii, Salmonella enterica, Stenotrophomonas maltophilia, Aspergillus ostianus, A. sydowii, Penicillium citrinum, and P. steckii have been detected. | na | What is the relationship between Stenotrophomonas maltophilia and Clostridium botulinum? |
1,057 | Fusobacterium | colorectal cancer | Similarly, Enterotoxigenic Bacteroides fragilis and Fusobacterium nucletum are identified to be highly expressed in colorectal cancer tissue compared to the matched tissue, and Fusobacterium nucletum is proved to be associated with high microsatellite instability [24]. | positive | What is the relationship between Fusobacterium and colorectal cancer? |
1,058 | Lactobacillus casei | diabetes | Oral inoculation (0.05%) or diet supplementation (0.1%) of heat-killed Lactobacillus casei in several mouse models including KK-Ay mice, NOD mice, and Alloxan-induced diabetic mice led to reduced plasma glucose level and diabetes development (171, 172). | negative | What is the relationship between Lactobacillus casei and diabetes? |
1,059 | Bacteroides fragilis | CRC | For example polysaccharide A (PSA) in Bacteroides fragilis inhibited CRC cell proliferation by controlling the cell cycle and impaired CRC cell migration and invasion by suppressing EMT (23). | negative | What is the relationship between Bacteroides fragilis and CRC? |
1,060 | SA | hypogammaglobulinemia | On the other hand, non-SA carriers seemed to have lower CD4 counts and a steeper decline of total Ig after 2 g of RTX and were more prone to infections and to discontinue RTX due to hypogammaglobulinemia. | na | What is the relationship between SA and hypogammaglobulinemia? |
1,061 | Enterococcus | UC | There were four genera significantly altered in all the PSC subgroups as compared with healthy controls?Enterococcus, Streptococcus, Lactobacillus and Fusobacterium, all but the latter exclusively associated?with PSC dysbiosis, and not with UC nor CD dysbiosis (figure 3B). | na | What is the relationship between Enterococcus and UC? |
1,062 | Lactobacillus acidophilus | gastric cancer | In the present study, the probiotic combination of Bifidobacterium infantis, Lactobacillus acidophilus, Enterococcus faecalis and Bacillus cereus was supplied to gastric cancer patients with partial gastrectomy, and their effect on reducing the severity of physiological disorders and microbial diversity in the stomach ... | relate | What is the relationship between Lactobacillus acidophilus and gastric cancer? |
1,063 | Hp | ulcer disease | Molecular interaction between streptococci and Hp may play a role in ulcer disease and deserves further investigation. | relate | What is the relationship between Hp and ulcer disease? |
1,064 | Clostridium | intestinal disorder | Bloom of a novel Clostridium species characterizes the ERE onset ERE is an intestinal disorder that develops very rapidly (rabbits diminish food intake abruptly and other signs of the disease appear within 48?h after disease initiation [8]). | relate | What is the relationship between Clostridium and intestinal disorder? |
1,065 | Clostridium | atherosclerosis | In contrast, HF diet induced significant increase in abundances of Lactobacillus, Allobaculum, Clostridium and Bifidobacterium (p?<?0.05), of which Clostridium and Bifidobacterium showed significant positive correlations with atherosclerotic lesion size at the sinus, aortic tree, plasma A-FABP, cholesterol, MMP-9 or sE... | positive | What is the relationship between Clostridium and atherosclerosis? |
1,066 | Akkermansia muciniphila | obesity | Postulated bacterial targets include: Akkermansia muciniphila, Lower numbers of this bacterium have been associated with diabetes, obesity, and IBD (31), and supplying a gluten-free diet to mice increased fecal levels of Akkermansia species (32). | negative | What is the relationship between Akkermansia muciniphila and obesity? |
1,067 | Lactobacillus fermentum | systemic inflammation | In combination with Lactobacillus fermentum, FOS were effective in preventing intestinal permeability, systemic inflammation, hepatic steatosis and insulin resistance without inducing an innate immune system reaction at the intestinal level during high fat diet (61). | positive | What is the relationship between Lactobacillus fermentum and systemic inflammation? |
1,068 | Fusobacterium nucleatum | tumor | Several bacterial populations, including Escherichia coli, Bacteroides fragilis, and Fusobacterium nucleatum, have been shown to directly influence tumor development in the colon. | relate | What is the relationship between Fusobacterium nucleatum and tumor? |
1,069 | Clostridium difficile | nosocomial GI?infection | Clostridioides difficile (previously?named Clostridium difficile 1) infection (CDI) is the major global cause of nosocomial GI?infection, with incidence rates increasing worldwide. | positive | What is the relationship between Clostridium difficile and nosocomial GI?infection? |
1,070 | Escherichia coli | PWD | However, all of the proposed putative pathogens including also Campylobacter jejuni, rota-, calici-, and mink coronavirus, Escherichia coli, and Staphylococcus delphini have also been isolated from clinically healthy kits, so their role in PWD remains elusive [10?13]. | na | What is the relationship between Escherichia coli and PWD? |
1,071 | Helicobacter pylori | immunodeficiency | In most cases, minimal lesions are attributable to other causes, including food allergies (e.g., cow milk proteins), Crohn?s disease, lymphocytic colitis, bacterial and parasitic intestinal infections, such as Giardia, common variable immunodeficiency, small intestinal bacterial overgrowth, non-steroidal anti-inflammat... | na | What is the relationship between Helicobacter pylori and immunodeficiency? |
1,072 | Fusobacterium | cancer | The candidate reason for observed poor prognosis may due to the inverse association between Fusobacterium nucletum and the infiltrated T-cell amount, which has a negative correlation with cancer, in the cancer sites [108]. | negative | What is the relationship between Fusobacterium and cancer? |
1,073 | Ruminococcus gnavus | UC | We observed a significant decrease of Ruminococcus gnavus in all diseased individuals, Png et al[46] described a manifold increase of this mucin-degrading species in the colonic mucosa of both CD and UC patients. | negative | What is the relationship between Ruminococcus gnavus and UC? |
1,074 | Blautia faecis | CD | At the species level, a considerable reduction of butyrate-producing bacterial species, as Blautia faecis, Roseburia inulinivorans, Ruminococcus torques, Clostridium lavalense, Bacteroides uniformis, and F. prausnitzii characterized CD patients respect to healthy subjects. | negative | What is the relationship between Blautia faecis and CD? |
1,075 | Akkermansia muciniphila | obesity | The Gram-negative, strictly anaerobic bacteria, Akkermansia muciniphila, widely studied for its anti-inflammatory effects, has been shown to be in close proximity to the intestinal epithelium, supporting the hypothesis that A. muciniphila plays a role in mutualistic interactions between the gut microbiota and host that... | relate | What is the relationship between Akkermansia muciniphila and obesity? |
1,076 | Lactobacillus reuteri | rheumatoid arthritis | Out of several hundreds of candidate strains, we selected Bifidobacterium bifidum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus reuteri, and Streptococcus thermophiles; mixture of these was named IRT5.22 Administration of IRT5 suppressed the development and progression of experimental autoimmune uveiti... | negative | What is the relationship between Lactobacillus reuteri and rheumatoid arthritis? |
1,077 | Lactococcus lactis | colitis | A mutant of Lactococcus lactis NZ3900 that produces mCRAMP was tested in a murine model of DSS-induced colitis for seven days. | na | What is the relationship between Lactococcus lactis and colitis? |
1,078 | Bacteroides fragilis | DSS-induced colitis | For example, TLR2 knockout mice demonstrated gut dysbiosis and aberrant immune responses, which were essential for Bacteroides fragilis-mediated prevention of DSS-induced colitis. | na | What is the relationship between Bacteroides fragilis and DSS-induced colitis? |
1,079 | PA | inflammatory bowel disease | Recent surveys revealed that intestinal PA detection rates were higher in patients with intestinal inflammatory morbidities including irritable bowel syndrome [17] or inflammatory bowel disease (IBD) such as ulcerative colitis [18]. | positive | What is the relationship between PA and inflammatory bowel disease? |
1,080 | Bifidobacterium breve | tumor | Oral administration of Bifidobacterium breve M-16V to the experimental NEC rats significantly decreased the expression of TLR-4, enhanced the expression of TLR-2, and suppressed pro-inflammatory cytokines, including IL-1 beta, IL-6 and tumor necrosis factor alpha that resulted from NEC induction. | na | What is the relationship between Bifidobacterium breve and tumor? |
1,081 | Akkermansia muciniphila | tumors | The abundance of Akkermansia is inversely related to mouse body weight, which contrasts the positive correlation of Bacteroides with high-fat and high-protein diets.33 Recent studies have shown that Akkermansia muciniphila can improve immunotherapy for epithelial-derived tumors.34 Therefore, the correlation between liv... | relate | What is the relationship between Akkermansia muciniphila and tumors? |
1,082 | Escherichia | IBD | Interestingly, Proteobacteria (Shigella/Escherichia) was among the top five dysbiosis?contributing bacterial groups for both IBS and IBD, implying similarities in dysbiosis between IBS and IBD. | relate | What is the relationship between Escherichia and IBD? |
1,083 | Clostridium difficile | inflammatory bowel disease | Most clinical experience with FMT to date has been in relation to the treatment of Clostridium difficile infections.11,12 However, FMT may also be effective in the treatment of other conditions associated with dysbiosis, such as inflammatory bowel disease, irritable bowel syndrome (IBS), and metabolic syndrome. | na | What is the relationship between Clostridium difficile and inflammatory bowel disease? |
1,084 | Akkermansia muciniphila | psoriasis | The skin microbiota in psoriasis patients seems to be less diverse when compared to healthy persons with a decrease in Coprococcus species[76], and more recently Akkermansia muciniphila[85]. | negative | What is the relationship between Akkermansia muciniphila and psoriasis? |
1,085 | Lactobacillus acidophilus | FMF | The probiotic Lactobacillus acidophilus INMIA 9602 Er 317/402 strain (Narine, Vitamax-E, Armenia) were prescribed to patients in each Narine FMF group. | na | What is the relationship between Lactobacillus acidophilus and FMF? |
1,086 | Lactobacillus gasseri | schizophrenia | Of these, the largest effect was observed in Lactobacillus gasseri, which appeared to be at least 400 times more abundant in schizophrenia patients than controls (log2 = 8.4 ? 1.2 standard error). | positive | What is the relationship between Lactobacillus gasseri and schizophrenia? |
1,087 | Lactobacillus acidophilus | hyperinsulinemia | [19] demonstrated that, Dahi (containing probiotic Lactobacillus acidophilus and Lactobacillus casei), a traditional India fermented milk product, demonstrated an inhibitory effect on development of glucose intolerance, hyperglycemia, hyperinsulinemia, dyslipidemia, and oxidative stress in high fructose-induced diabeti... | negative | What is the relationship between Lactobacillus acidophilus and hyperinsulinemia? |
1,088 | Prevotella copri | bacterial infection | Among the bacteria constituting the intestinal microbiota, Lmo2776 specifically inhibits Prevotella copri that causes mucus erosion and exacerbates inflammation and bacterial infection in the intestine [53]. | negative | What is the relationship between Prevotella copri and bacterial infection? |
1,089 | Ruminococcus | obese | Previous studies have demonstrated that decreased relative abundance of Akkermansia and increased relative abundance of Bacteroides, Ruminococcus and Parabacteroides in the gut microbiome can improve glucose homeostasis in obese mice and provide a catabolic pathway through a novel mannosylglucose phosphorylase, suggest... | na | What is the relationship between Ruminococcus and obese? |
1,090 | Streptococcus | pneumonia | These findings are pertinent in light of our re-analysis of the Monaco et al.cohort which indicates that gut microbiome enrichment of Streptococcus and Veillonella in HIV-infected patients with low CD4+ cell counts is more generalizable and occurs irrespective of pneumonia or HIV treatment, and?may be indicative of tra... | relate | What is the relationship between Streptococcus and pneumonia? |
1,091 | Clostridium | CD | In line with previous studies, some representative species from phylum Firmicutes including genus Eubacterium, Blautia, Clostridium and Lactobacillus, increased in HFD group compared with CD group (Fig?5d). | na | What is the relationship between Clostridium and CD? |
1,092 | Blautia hydrogenotrophica | IBS | Single LBPs being considered, in development or under evaluation, include Blautia hydrogenotrophica for IBS (http://www.researchandmarkets.com/reports/3961131/irritable-bowel-syndrome-pipeline-review-h2#), Eubacterium hallii for metabolic disease (Udayappan et?al., 2016), Lactobacillus reuteri for type 2 diabetes (Mobi... | relate | What is the relationship between Blautia hydrogenotrophica and IBS? |
1,093 | Escherichia | ASD | Our study also suggested Streptococcus and Escherichia were depleted in ASD subjects in comparison to control subjects, in line with the results obtained in previous study44. | negative | What is the relationship between Escherichia and ASD? |
1,094 | Bacteroides caccae | type 2 diabetes | Metagenome?wide?association?study evaluation of the gut microbial metagenome data of 345 type 2 diabetes patients and non?type 2 diabetes Chinese individuals by Qin et al.28 showed that genes enriched in the type 2 diabetes group mainly comprised of opportunistic pathogens, such as Bacteroides caccae, Clostridium hathe... | positive | What is the relationship between Bacteroides caccae and type 2 diabetes? |
1,095 | Lactobacillus | PSC | At the species level, seven taxa belonging to genera Rothia, Lactobacillus, Streptococcus and Veillonella, were overrepresented, specifically in PSC patients, compared with both HCs and patients with UC (Table 3). | positive | What is the relationship between Lactobacillus and PSC? |
1,096 | Ruminococcus | IBD | As with A. muciniphila, mucosal numbers of Ruminococcus species are altered in individuals with IBD [12]. | relate | What is the relationship between Ruminococcus and IBD? |
1,097 | Clostridium | WD | Among these, Lactobacillus, Faecalibacterium, Clostridium, Oscillospira, and Prevotella exhibited the most prominent difference with significantly or insignificantly higher abundance in MD vs. WD group (Figure 3B) whereas Ruminococcus and Coprococcus exhibited an opposite trend, i.e., a significantly lower relative abu... | positive | What is the relationship between Clostridium and WD? |
1,098 | Lactobacillus rhamnosus | colon cancer | The aim of this work is to investigate the effect of supplementation of a Lactobacillus acidophilus, Lactobacillus rhamnosus and Bifidobacterium bifidum mixture on the intestinal microbiota composition, inflammation and neoplastic alterations in the colon during the development of an experimental model of colitis assoc... | na | What is the relationship between Lactobacillus rhamnosus and colon cancer? |
1,099 | Clostridium | Cancer | Furthermore, nine bacteria, Alistipes, Bacteroides, Blautia, Clostridium, Dorea, Escherichia, Faecalibacterium, Megamonas, and Phascolarctobacterium, displayed positive correlations with each other in the Epithelial precursor lesion and Cancer groups. | positive | What is the relationship between Clostridium and Cancer? |
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