TITLE: Why is $2^{16}=65536$ the only power of $2$ less than $2^{31000}$ that doesn't contain the digits $1$, $2$, $4$ or $8$ in its decimal representation?
QUESTION [6 upvotes]: $65536$ is the only power of $2$ less than $2^{31000}$ that does not contain the digits $1$, $2$, $4$ or $8$ in its decimal representation.

http://en.wikipedia.org/wiki/65536_%28number%29

REPLY [3 votes]: A simple explanation turns on the apparent randomness of the base-$b$ digits of sufficiently large powers of two, in the sense that they tend to behave like random samples. (However, this leaves the apparent randomness unexplained.) 
Thus, let $S_k$ denote the multiset of digits appearing in the numeral of $2^k$, and let $n_k$ be their number; i.e., $n_k = \lfloor 1 + k\cdot log_{b}2\rfloor $. If each $S_k$ were a simple random sample, then, for any $K$ and any subset $D\subset \{0,1,...,b-1\}$ (e.g., $D=\{1,2,4,8\}, \ b=10$), 
$$\begin{align}
P_K &= P(\text{at least one digit from D appears in *every* }S_K, S_{K+1}, S_{K+2},...)\\
&= P\left( \bigcap_{i=K}^\infty C_{i} \right)\\
&= \prod_{i=K}^\infty P(C_{i})\\
&= \prod_{i=K}^\infty(1-q^{n_i})
\end{align}
$$
where 
$C_i = \{S_i\cap D \ne \oslash\}$,  
$q = P(\text{digit } \notin D) = 1 - \frac{|D|}{b}$.
Here are some computed cases (rounded) for $b=10$ and $|D|=4$:
\begin{array}{|c|c|} K & P_K \\
\hline
1&0.002\\
10&0.304\\
15&0.575\\
20&0.780\\
50&0.998\\
100&0.999999\\
200&0.9999999999999
\end{array}
As examples, I've verified that 

with $D=\{1,2,4,8\}$ and $b=10$, a digit from $D$ occurs among the digits of every $2^k$ for the range $17\le k\le 200000$ 
with $D=\{1,2,3,4\}$ and $b=10$, a digit from $D$ occurs among the digits of every $2^k$ for the range $4\le k\le 200000$

Therefore, it seems extremely likely that both of these statements are true:

$2^{16}$ is the only power of two that does not contain a digit from $\{1,2,4,8\}$.
$2^3$ is the only power of two that does not contain a digit from $\{1,2,3,4\}$.

NB: These are examples of probably true and unprovable "Dyson statements".