TITLE: (Homotopy theory) When does the 2 of 3 property not imply 2 of 6?
QUESTION [11 upvotes]: A relative category is a category $C$ with a subcategory $W$ containing all the objects of $C$.  
Given a relative category $(C,W)$, $W$ is said to satisfy the ``2 implies 6'' property if, for any collection of three composable maps,
$$X\rightarrow Y\rightarrow Z\rightarrow A$$
the presence of the composites $X\rightarrow Z$ and $Y\rightarrow A$ in $W$ implies that each individual map is in $W$ (and so also the triple composition).
The property I'm more familiar with from thinking about weak equivalences is the ``2 implies 3" property, which says that, given a pair of composable maps
$$X\rightarrow Y\rightarrow Z$$
the presence of any two of the maps 
$$X\rightarrow Y$$
$$Y\rightarrow Z$$
$$X\rightarrow Z$$
in $W$ implies that the third is as well.
The "2 implies 6" property implies the "2 implies 3" property, and I've been told that "2 implies 6" is a strictly stronger property.  
QUESTION: What is the basic example of a relative category $(C,W)$ where $W$ satisfies "2 implies 3", but not "2 implies 6"?  
Edit: By "basic", I mean what is an example which comes up in applications, or better yet, what is the example to keep in mind?

REPLY [9 votes]: Here is an example, which I got from a discussion with Karol Szumilo (and maybe he got it from Cisinski?). 
Consider the notion of a cofibration category, which means essentially that you have weak equivalences (with 2 out of 3), cofibrations (closed under pushouts and the same is true for trivial cofibrations) and you can factor everything into a cofibration and a weak equivalence. According to the Radulescu-Banu article https://arxiv.org/pdf/math/0610009v4.pdf (Theorem 7.2.7) we have the following theorem:

A cofibration category is saturated iff weak equivalences fulfill 2
  out of 6 iff they are closed under retracts.

Thus, we have just to find a cofibration category where weak equivalences are not closed under retracts. Let $R$ be a ring such that its reduced $K_0$ is non-trivial (i.e. there are projective modules that are not stably free). Consider first the cofibration category $Ch_R$ of bounded chain complexes, where weak equivalences are quasi-isomorphisms and the cofibrations $\mathcal{C}$ are injections with levelwise projective cokernel. Its homotopy category $\mathrm{Ho}(Ch_R)$ is the usual bounded derived category of $R$. This is a triangulated category and its $K_0$ agrees with the $K_0$ of the ring (where we define $K_0$ of a triangulated category as the free abelian group on all isomorphism classes of objects modulo the relation that $[X]+[Z] = [Y]$ if there is a triangle 
$$X \to Y \to Z \to X[1].)$$ 
We define its reduced K-theory $\tilde{K}_0$ by taking the quotient by the subgroup generated by $R$ itself concentrated in degree $0$. 
We want to localize $Ch_R$ at the class of morphisms $f \in \mathcal{W}$ such that the cone $C(f)$ is zero in $\tilde{K}_0$. First we show that $\mathcal{W}$ satisfies $2$ out of $3$:
Let $f$ and $g$ be composable morphisms. Then we get by the octahedral axiom a triangle in $\mathrm{Ho}(Ch_R)$ of the form
$$C(f) \to C(gf) \to C(g) \to C(f)[1].$$
By the defining relation of K-theory, the third of these cones is zero in $\tilde{K}_0$ if the other two are. 
To show now that $(\mathcal{W},\mathcal{C})$ is a cofibration category, we just have to show $\mathcal{W}$ is closed under homotopy pushouts in $Ch_R$. This is clear as the homotopy pushout of a map $f$ has an equivalent cone to $C(f)$. 
Last we have to show that $\mathcal{W}$ is not closed under retracts. But this is clear: Just take a projective $R$-module $P$ that is nonzero in $\tilde{K}_0$ and write it as a retract of a free $R$-module $R^n$. Then $0 \to R^n$ is in $\mathcal{W}$, but $0\to P$ is not in $\mathcal{W}$ (where we view this maps as maps of chain complexes concentrated in degree $0$). 

Upshot: Most of the time $2$ out of $6$ is fine, but there are some natural examples where one only has $2$ out of $3$. This should be reason enough to set up the theory with $2$ out of $3$ and only later introduced $2$ out of $6$.