TITLE: Number of all different $n\times n$ matrices where sum of rows and columns is $3$
QUESTION [8 upvotes]: For a given positive integer $n$, I need to learn the number of $n\times n$ matrices of nonnegative integers with the following restrictions:

The sum of each row and column is equal to $3$.
Two matrices are considered equal if one can be obtained by permuting rows and/or columns.

For example, for $n=2$ there are two different matrices as follows:
$$M_1=\begin{pmatrix}
1&2\\2&1
\end{pmatrix},\qquad M_2=\begin{pmatrix}
3&0\\0&3
\end{pmatrix}.$$
For $n=3$ there are five different matrices as follows:
$$\begin{pmatrix}
1&1&1\\1&1&1\\1&1&1
\end{pmatrix},\quad \begin{pmatrix}
0&1&2\\1&2&0\\2&0&1
\end{pmatrix}, \quad \begin{pmatrix}
0&1&2\\1&1&1\\2&1&0
\end{pmatrix}, \quad \begin{pmatrix}
1&2&0\\2&1&0\\0&0&3
\end{pmatrix}, \quad \begin{pmatrix}
3&0&0\\0&3&0\\0&0&3
\end{pmatrix}.$$

REPLY [3 votes]: http://oeis.org/A001501 has an enumeration of binary matrices with row and column sums equal to 3.  If n is the order of the matrix, the count grows like n^{3n}. You want classes up to row and column permutations, so your number will grow like n^n.
There are some details to handle, but most of your cases reduce to the following. Such a matrix will be equivalent to one with t 3's on the diagonal, s 2x2 diagonal blocks with 2's and 1's, r more 2's on the diagonal with parallel offset diagonals having 1's, and a remaining block of size qxq with q=n-(t+2s+r), and this block is like one of your matrices but it is binary, and unless r is small you can arrange r zeros on the upper diagonal. When you flip those r diagonal entries from 0 to 1, the qxq block is like one of the matrices enumerated by the OEIS sequence above.  So an upper bound will be of order n^{n+3} or smaller.  A professional combinatorialist can tighten up the bound for you.
Gerhard "Doesn't Need To Be Professional" Paseman, 2016.10.11.