Update oral V25 L5 to degree 24 and refit per-level targets

README.md

@@ -12,7 +12,7 @@ configs:
 # Oral bioavailability V25
 
 Independent L2-L6 releases derived from the frozen consolidated oral V24.1 splits.
-Record degree is six separately for query and reference roles. Parent molecule
+Record degree is 24 for L5 and six for L2/L3/L4/L6, separately for query and reference roles. Parent molecule
 budgets remain 4096 per role, level, and binary/nonbinary family. Minority-first
 sampling, compatible-endpoint repair, and final binary 75/25 trimming are retained.
 Low degree and binary trimming can leave records unused; see record_coverage.json.
@@ -32,4 +32,4 @@ Internal v24.2 sampler/schema names identify reused algorithms, not the release.
 
 Level: L5
 
-Pair rows: {'train': 6892, 'validation_ranking': 23836, 'test_ranking': 22957}
+Pair rows: {'train': 29954, 'validation_ranking': 23836, 'test_ranking': 22957}

calibration.json

@@ -34475,10 +34475,10 @@
     "group_by": "level",
     "levels": {
       "L5": {
-        "far_numeric_pair_count": 1757,
-        "match_probability": 0.8757556917398003,
-        "mismatch_probability": 0.07795156768942206,
-        "near_numeric_pair_count": 1737
+        "far_numeric_pair_count": 6012,
+        "match_probability": 0.8867075712609757,
+        "mismatch_probability": 0.07231156681921541,
+        "near_numeric_pair_count": 4893
       }
     },
     "schema_version": "assay_transfer_empirical_binary_targets.v24.2.level",

manifest.json

@@ -1,17 +1,17 @@
 {
   "artifacts": {
-    "README.md": "bbff05e6ce27ce31c5503d57ef81dceafdef8fea37fcceb18a0377dd75de1895",
-    "calibration.json": "b0911153c12072bc869aa71243a25cea2f35551590d6fb305dcfdf78a547a782",
-    "record_coverage.json": "156cbb624f668767c671641896c6f94af4823be509713475f45040b20191ed57",
-    "test_ranking/data.parquet": "2c531077c83ec21c8f108f3baa31b6616126f24ccb810a41dd3ff10f62744ad5",
-    "train/data.parquet": "9f05b4255f279e703d1367912c6e6362efd88eb33fc3bade636c5d12ade4ee92",
-    "validation_ranking/data.parquet": "ca349a68706c7d79f2154bbbfde5aede4e6e642e16b9c3b27a621d836d00574f"
+    "README.md": "276c5cc4059114155698a3f5f380227b579df3e8d45685b7e345e05e44714f6a",
+    "calibration.json": "ba5f07c876284074163b9ec5a6e974ff8b00efecae4679c6e0cbab7b47d0d8a0",
+    "record_coverage.json": "a8cecbe8bfb864424c4d70833547c0f7d38bdc4598a21659e30077dbe978c33f",
+    "test_ranking/data.parquet": "f98cd90ac8f861f3d6193be7b2fd7caab47d73bfcb77b233bc76c57b6124ce36",
+    "train/data.parquet": "2a0f76c7fb4a13d136371bb0042c0512b6c7ead0ddb30495714e91de67190ff4",
+    "validation_ranking/data.parquet": "7092756431eada40aca87965e4d2d7277ba701a080fee11f549aeaaa9b1dcdaa"
   },
   "binary_limit": "75/25",
-  "binary_target_fit_train_sha256": "03ca24437409a387bbb0f26f7313ac6dcaff28fcf2946c77d03eb8c3cb0c5232",
+  "binary_target_fit_train_sha256": "5cd935b39acb9b9e5d80f591ec9e398bc47977c4661c39fac082560d99d7ba1c",
   "binary_target_group_by": "level",
   "continuous_limit": "soft",
-  "degree_cap": 6,
+  "degree_cap": 24,
   "full_universe_audit": {
     "test_gate_only": {
       "parent_id_count": 454,
@@ -41,18 +41,18 @@
     "/vast/projects/myatskar/design-documents/joseph/starling_assay_transfer/assay_transfer/record_level/oral_v24_2/sampling.py": "9e2b8171246b07aa6c57b6824a48ec240512773d2f1c95054ffdffc5d0ca534f",
     "/vast/projects/myatskar/design-documents/joseph/starling_assay_transfer/assay_transfer/record_level/oral_v24_2/splits.py": "ac982cb9e20dc35c9ef043d0d421c08a1b470129e80ecf472aa6c19aa5720a3c",
     "/vast/projects/myatskar/design-documents/joseph/starling_assay_transfer/assay_transfer/record_level/oral_v24_2/verify.py": "6ec4f8913d2861639a77ef1f906219a0fd8258eb35c8b61405b5658cd3137f49",
-    "/vast/projects/myatskar/design-documents/joseph/starling_assay_transfer/assay_transfer/record_level/oral_v25.py": "70e935aeb35ab21ec5754391eadab8cdf65a86a5c7cb0ecb086df6b3eb13798e"
+    "/vast/projects/myatskar/design-documents/joseph/starling_assay_transfer/assay_transfer/record_level/oral_v25.py": "365184843e25f3430abad12f44e373775d2a2b259572fdfcd63dd0b8433d1017"
   },
   "independent_test_evaluation": true,
   "level": "L5",
-  "pair_manifest_sha256": "fdd8417fdb76bb1ec67150d3665c162d76412307f4b50c6ecb00338533aad222",
+  "pair_manifest_sha256": "a593fecebf093e91a8626185ccf9e1599d87337649b27524b75ec3b83eb5672e",
   "parent_cap_per_role_within_level": 4096,
   "parent_cap_scope": "within_level_and_budget_family",
   "ranking_id_max_references": 50,
   "release_id": "oral_v25",
   "rows": {
     "test_ranking": 22957,
-    "train": 6892,
+    "train": 29954,
     "validation_ranking": 23836
   },
   "selection": {

record_coverage.json

@@ -1,26 +1,26 @@
 {
   "query": {
-    "maximum": 6,
-    "median": 0.0,
+    "maximum": 24,
+    "median": 7.0,
     "minimum": 0,
     "p10": 0.0,
     "records": 3386,
-    "zero": 1899
+    "zero": 837
   },
   "reference": {
-    "maximum": 6,
-    "median": 1.0,
+    "maximum": 24,
+    "median": 5.0,
     "minimum": 0,
-    "p10": 0.0,
+    "p10": 2.0,
     "records": 3386,
-    "zero": 961
+    "zero": 12
   },
   "total": {
-    "maximum": 12,
-    "median": 2.0,
+    "maximum": 48,
+    "median": 13.0,
     "minimum": 0,
-    "p10": 0.0,
+    "p10": 4.0,
     "records": 3386,
-    "zero": 698
+    "zero": 9
   }
 }

test_ranking/data.parquet

@@ -1,3 +1,3 @@
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+size 8776372

train/data.parquet

@@ -1,3 +1,3 @@
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+size 11503768

validation_ranking/data.parquet

@@ -1,3 +1,3 @@
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