{ "accepted_buckets": { "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"CCK-8 cell viability/proliferation (2D planar)\",\"human\",\"L3\"]": { "bucket_total_parent_count": 30, "bucket_total_record_count": 51, "bucket_train_parent_count": 30, "bucket_train_record_count": 51, "calibration_sample_standard_deviation": 129.30552431378766, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.8795746940534701, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.06283410536697116, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 30, "ratio_gate_record_count": 51, "ratio_gate_repeated_parent_count": 9, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 21, "train_parent_count": 30, "train_record_count": 51, "unweighted_parent_mean_variance": 0.9753693382300287, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"CCK-8 cell viability/proliferation (2D planar)\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.06442083311845151 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"HepG2 antiproliferative/cytotoxicity IC50 assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 37, "bucket_total_record_count": 38, "bucket_train_parent_count": 36, "bucket_train_record_count": 37, "calibration_sample_standard_deviation": 2926.899203361862, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.9186780763305126, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.0033473660208366007, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 38, "ratio_gate_record_count": 39, "ratio_gate_repeated_parent_count": 1, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 1, "ratio_gate_within_df": 1, "train_parent_count": 36, "train_record_count": 37, "unweighted_parent_mean_variance": 0.8341521417709525, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"HepG2 antiproliferative/cytotoxicity IC50 assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.004012896273010763 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"HepG2 cell viability/cytotoxicity IC50 assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 27, "bucket_total_record_count": 27, "bucket_train_parent_count": 26, "bucket_train_record_count": 26, "calibration_sample_standard_deviation": 108.09071710302487, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.8067257649055743, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": null, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 27, "ratio_gate_record_count": 27, "ratio_gate_repeated_parent_count": 0, "ratio_gate_status": "undefined_allowed", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 0, "train_parent_count": 26, "train_record_count": 26, "unweighted_parent_mean_variance": 0.6542759982004306, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"HepG2 cell viability/cytotoxicity IC50 assay\",\"human\"]", "within_to_parent_mean_variance_ratio": null }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"MTT cell viability assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 346, "bucket_total_record_count": 525, "bucket_train_parent_count": 340, "bucket_train_record_count": 513, "calibration_sample_standard_deviation": 192.48109941531678, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.8355137874727669, "logit_geometry_sd_inflation": 1.0634082367245186, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.14822172161253133, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 349, "ratio_gate_record_count": 529, "ratio_gate_repeated_parent_count": 82, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 4, "ratio_gate_within_df": 180, "train_parent_count": 340, "train_record_count": 513, "unweighted_parent_mean_variance": 0.702204609125776, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"MTT cell viability assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.21108053078299074 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"MTT cell viability assay\",\"mouse\",\"L3\"]": { "bucket_total_parent_count": 16, "bucket_total_record_count": 20, "bucket_train_parent_count": 16, "bucket_train_record_count": 20, "calibration_sample_standard_deviation": 11.672372870203068, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 11.672372870203068, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 11.58125, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 16, "ratio_gate_record_count": 20, "ratio_gate_repeated_parent_count": 2, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 4, "train_parent_count": 16, "train_record_count": 20, "unweighted_parent_mean_variance": 146.44415625, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"MTT cell viability assay\",\"mouse\"]", "within_to_parent_mean_variance_ratio": 0.07908304637454594 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"MTT reduction cell viability assay\",\"human\",\"L2\"]": { "bucket_total_parent_count": 11, "bucket_total_record_count": 11, "bucket_train_parent_count": 9, "bucket_train_record_count": 9, "calibration_sample_standard_deviation": 303.86179979418876, "calibration_scope": "whole_bucket_ood.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L2", "logit_calibration_sample_standard_deviation": 303.86179979418876, "logit_geometry_sd_inflation": 2.451029793139828, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": null, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 11, "ratio_gate_record_count": 11, "ratio_gate_repeated_parent_count": 0, "ratio_gate_status": "undefined_allowed", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 0, "train_parent_count": 11, "train_record_count": 11, "unweighted_parent_mean_variance": 92331.99337416363, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"MTT reduction cell viability assay\",\"human\"]", "within_to_parent_mean_variance_ratio": null }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"MTT reduction cell viability assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 93, "bucket_total_record_count": 144, "bucket_train_parent_count": 91, "bucket_train_record_count": 142, "calibration_sample_standard_deviation": 157.39211923947983, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 1.029881762852343, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.10747351370657571, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 93, "ratio_gate_record_count": 144, "ratio_gate_repeated_parent_count": 21, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 51, "train_parent_count": 91, "train_record_count": 142, "unweighted_parent_mean_variance": 1.0146606855778848, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"MTT reduction cell viability assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.10592064444220166 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"MTT reduction cell viability assay\",\"rat\",\"L3\"]": { "bucket_total_parent_count": 37, "bucket_total_record_count": 56, "bucket_train_parent_count": 35, "bucket_train_record_count": 53, "calibration_sample_standard_deviation": 927.0724272449751, "calibration_scope": "whole_bucket_ood.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.8131193824332958, "logit_geometry_sd_inflation": 1.1763922681491918, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.08693025924061706, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 37, "ratio_gate_record_count": 56, "ratio_gate_repeated_parent_count": 13, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 19, "train_parent_count": 37, "train_record_count": 56, "unweighted_parent_mean_variance": 0.8464072388948943, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"MTT reduction cell viability assay\",\"rat\"]", "within_to_parent_mean_variance_ratio": 0.10270500445402257 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"MTT reduction cell viability/metabolic activity assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 106, "bucket_total_record_count": 134, "bucket_train_parent_count": 104, "bucket_train_record_count": 132, "calibration_sample_standard_deviation": 51.15528209418186, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.8253574663614801, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.13917851823008545, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 106, "ratio_gate_record_count": 134, "ratio_gate_repeated_parent_count": 14, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 28, "train_parent_count": 104, "train_record_count": 132, "unweighted_parent_mean_variance": 0.6398461222746632, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"MTT reduction cell viability/metabolic activity assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.21751873362192709 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"MTT reduction metabolic viability assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 34, "bucket_total_record_count": 36, "bucket_train_parent_count": 34, "bucket_train_record_count": 36, "calibration_sample_standard_deviation": 31.005597757527386, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 31.005597757527386, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 11.222500000000009, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 34, "ratio_gate_record_count": 36, "ratio_gate_repeated_parent_count": 2, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 2, "train_parent_count": 34, "train_record_count": 36, "unweighted_parent_mean_variance": 682.5392962566845, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"MTT reduction metabolic viability assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.016442276747358927 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"WST-1 tetrazolium reduction viability assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 16, "bucket_total_record_count": 25, "bucket_train_parent_count": 16, "bucket_train_record_count": 25, "calibration_sample_standard_deviation": 4383.292826091593, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 1.252905083672256, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.16399670116474527, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 18, "ratio_gate_record_count": 27, "ratio_gate_repeated_parent_count": 2, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 2, "ratio_gate_within_df": 9, "train_parent_count": 16, "train_record_count": 25, "unweighted_parent_mean_variance": 1.128513164185606, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"WST-1 tetrazolium reduction viability assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.14532103511888922 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"WST-8/CCK-8 cell viability assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 22, "bucket_total_record_count": 46, "bucket_train_parent_count": 21, "bucket_train_record_count": 44, "calibration_sample_standard_deviation": 70.9887278241625, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.8729688262032563, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.2129457211002677, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 22, "ratio_gate_record_count": 46, "ratio_gate_repeated_parent_count": 9, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 24, "train_parent_count": 21, "train_record_count": 44, "unweighted_parent_mean_variance": 0.5632932996065242, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"WST-8/CCK-8 cell viability assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.3780370212978143 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"WST-8/CCK-8 cell viability/proliferation assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 16, "bucket_total_record_count": 48, "bucket_train_parent_count": 16, "bucket_train_record_count": 48, "calibration_sample_standard_deviation": 39.65663910435109, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 39.65663910435109, "logit_geometry_sd_inflation": 1.3152179590743547, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 200.02903596788192, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 16, "ratio_gate_record_count": 48, "ratio_gate_repeated_parent_count": 11, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 32, "train_parent_count": 16, "train_record_count": 48, "unweighted_parent_mean_variance": 2748.932651569107, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"WST-8/CCK-8 cell viability/proliferation assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.07276607371726775 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"cell death\",\"mouse\",\"L6\"]": { "bucket_total_parent_count": 14, "bucket_total_record_count": 18, "bucket_train_parent_count": 14, "bucket_train_record_count": 18, "calibration_sample_standard_deviation": 31.25772322863437, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L6", "logit_calibration_sample_standard_deviation": 31.25772322863437, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.0, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 14, "ratio_gate_record_count": 18, "ratio_gate_repeated_parent_count": 4, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 4, "train_parent_count": 14, "train_record_count": 18, "unweighted_parent_mean_variance": 1087.7853296703297, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"cell death\",\"mouse\"]", "within_to_parent_mean_variance_ratio": 0.0 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"cell proliferation/growth inhibition assay (IC50)\",\"human\",\"L3\"]": { "bucket_total_parent_count": 58, "bucket_total_record_count": 74, "bucket_train_parent_count": 58, "bucket_train_record_count": 74, "calibration_sample_standard_deviation": 49.38728632170571, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.8430915376817272, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.2622629356181083, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 59, "ratio_gate_record_count": 76, "ratio_gate_repeated_parent_count": 7, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 2, "ratio_gate_within_df": 17, "train_parent_count": 58, "train_record_count": 74, "unweighted_parent_mean_variance": 0.7096210827635242, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"cell proliferation/growth inhibition assay (IC50)\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.369581657011599 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"cell viability (CCK-8/WST-8)\",\"human\",\"L3\"]": { "bucket_total_parent_count": 18, "bucket_total_record_count": 22, "bucket_train_parent_count": 16, "bucket_train_record_count": 20, "calibration_sample_standard_deviation": 83.3259805295051, "calibration_scope": "whole_bucket_ood.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.8320905613471077, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.04835992441502905, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 18, "ratio_gate_record_count": 22, "ratio_gate_repeated_parent_count": 3, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 4, "train_parent_count": 18, "train_record_count": 22, "unweighted_parent_mean_variance": 0.7562307173904611, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"cell viability (CCK-8/WST-8)\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.06394863803192961 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"cell viability (unspecified method)\",\"human\",\"L3\"]": { "bucket_total_parent_count": 58, "bucket_total_record_count": 88, "bucket_train_parent_count": 58, "bucket_train_record_count": 88, "calibration_sample_standard_deviation": 133.219821649025, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.8357810259410935, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.20344458340405444, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 59, "ratio_gate_record_count": 90, "ratio_gate_repeated_parent_count": 16, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 2, "ratio_gate_within_df": 31, "train_parent_count": 58, "train_record_count": 88, "unweighted_parent_mean_variance": 0.6880802926701463, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"cell viability (unspecified method)\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.2956698303544965 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"cell viability (unspecified method)\",\"mouse\",\"L6\"]": { "bucket_total_parent_count": 25, "bucket_total_record_count": 26, "bucket_train_parent_count": 25, "bucket_train_record_count": 26, "calibration_sample_standard_deviation": 39.076645002039065, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L6", "logit_calibration_sample_standard_deviation": 39.076645002039065, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 47.04499999999996, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 25, "ratio_gate_record_count": 26, "ratio_gate_repeated_parent_count": 1, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 1, "train_parent_count": 25, "train_record_count": 26, "unweighted_parent_mean_variance": 1572.6675166666666, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"cell viability (unspecified method)\",\"mouse\"]", "within_to_parent_mean_variance_ratio": 0.029914142373661898 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"cell viability assay\",\"human\",\"L2\"]": { "bucket_total_parent_count": 23, "bucket_total_record_count": 24, "bucket_train_parent_count": 21, "bucket_train_record_count": 22, "calibration_sample_standard_deviation": 85.0867941029166, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L2", "logit_calibration_sample_standard_deviation": 1.1224406316500148, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.010056352939579885, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 25, "ratio_gate_record_count": 26, "ratio_gate_repeated_parent_count": 1, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 2, "ratio_gate_within_df": 1, "train_parent_count": 21, "train_record_count": 22, "unweighted_parent_mean_variance": 1.237606489373962, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"cell viability assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.008125646581464557 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"cell viability assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 79, "bucket_total_record_count": 114, "bucket_train_parent_count": 77, "bucket_train_record_count": 108, "calibration_sample_standard_deviation": 2174.7007519345543, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 1.0788518557621194, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.14461208636669698, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 79, "ratio_gate_record_count": 114, "ratio_gate_repeated_parent_count": 21, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 35, "train_parent_count": 77, "train_record_count": 108, "unweighted_parent_mean_variance": 1.0368805008788717, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"cell viability assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.13946842113832994 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"cellular IC50 determination assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 22, "bucket_total_record_count": 22, "bucket_train_parent_count": 22, "bucket_train_record_count": 22, "calibration_sample_standard_deviation": 19.95595910501086, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 19.95595910501086, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": null, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 22, "ratio_gate_record_count": 22, "ratio_gate_repeated_parent_count": 0, "ratio_gate_status": "undefined_allowed", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 0, "train_parent_count": 22, "train_record_count": 22, "unweighted_parent_mean_variance": 398.24030380086583, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"cellular IC50 determination assay\",\"human\"]", "within_to_parent_mean_variance_ratio": null }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"cytotoxicity (cell viability)\",\"rat\",\"L3\"]": { "bucket_total_parent_count": 18, "bucket_total_record_count": 26, "bucket_train_parent_count": 18, "bucket_train_record_count": 26, "calibration_sample_standard_deviation": 7375.2230959336985, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.8857702375310351, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.03473162841828443, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 18, "ratio_gate_record_count": 26, "ratio_gate_repeated_parent_count": 8, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 8, "train_parent_count": 18, "train_record_count": 26, "unweighted_parent_mean_variance": 0.6583909088130694, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"cytotoxicity (cell viability)\",\"rat\"]", "within_to_parent_mean_variance_ratio": 0.05275229039978352 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"cytotoxicity (unspecified readout)\",\"rat\",\"L3\"]": { "bucket_total_parent_count": 15, "bucket_total_record_count": 15, "bucket_train_parent_count": 15, "bucket_train_record_count": 15, "calibration_sample_standard_deviation": 11535.861604690455, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 11535.861604690455, "logit_geometry_sd_inflation": 34.55942085452155, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": null, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 16, "ratio_gate_record_count": 16, "ratio_gate_repeated_parent_count": 0, "ratio_gate_status": "undefined_allowed", "ratio_gate_test_record_count": 1, "ratio_gate_within_df": 0, "train_parent_count": 15, "train_record_count": 15, "unweighted_parent_mean_variance": 124831056.65466666, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"cytotoxicity (unspecified readout)\",\"rat\"]", "within_to_parent_mean_variance_ratio": null }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"cytotoxicity IC50\",\"human\",\"L3\"]": { "bucket_total_parent_count": 47, "bucket_total_record_count": 62, "bucket_train_parent_count": 45, "bucket_train_record_count": 60, "calibration_sample_standard_deviation": 1076.8110928613025, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.7869143277068095, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.058821966050979585, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 47, "ratio_gate_record_count": 62, "ratio_gate_repeated_parent_count": 12, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 15, "train_parent_count": 45, "train_record_count": 60, "unweighted_parent_mean_variance": 0.600945074208201, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"cytotoxicity IC50\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.09788243314662792 }, "[\"dili_v1\",\"cell_viability\",\"\\u00b5M\",\"__unknown__\",\"resazurin reduction cell viability/metabolic activity assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 30, "bucket_total_record_count": 41, "bucket_train_parent_count": 29, "bucket_train_record_count": 40, "calibration_sample_standard_deviation": 115.26060964328158, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.9589280607203547, "logit_geometry_sd_inflation": 1.3538846189122837, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.057795562716845224, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 30, "ratio_gate_record_count": 41, "ratio_gate_repeated_parent_count": 8, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 11, "train_parent_count": 29, "train_record_count": 40, "unweighted_parent_mean_variance": 1.3925692446488838, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"\u00b5M\",\"__unknown__\",\"resazurin reduction cell viability/metabolic activity assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.04150282863055585 }, "[\"dili_v1\",\"cell_viability\",\"mmol_per_l\",\"__unknown__\",\"MTT cell viability assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 27, "bucket_total_record_count": 37, "bucket_train_parent_count": 26, "bucket_train_record_count": 36, "calibration_sample_standard_deviation": 144.26213857882362, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.7879125938575728, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.050997654028284246, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 28, "ratio_gate_record_count": 39, "ratio_gate_repeated_parent_count": 9, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 2, "ratio_gate_within_df": 11, "train_parent_count": 26, "train_record_count": 36, "unweighted_parent_mean_variance": 0.7452606416856501, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"mmol_per_l\",\"__unknown__\",\"MTT cell viability assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.06842928658212302 }, "[\"dili_v1\",\"cell_viability\",\"uM\",\"__unknown__\",\"MTT cell viability assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 69, "bucket_total_record_count": 107, "bucket_train_parent_count": 69, "bucket_train_record_count": 107, "calibration_sample_standard_deviation": 193.06719777838646, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.9597514216088792, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.07793805162835214, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 69, "ratio_gate_record_count": 107, "ratio_gate_repeated_parent_count": 21, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 38, "train_parent_count": 69, "train_record_count": 107, "unweighted_parent_mean_variance": 1.1578263554712167, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"uM\",\"__unknown__\",\"MTT cell viability assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.06731411084232282 }, "[\"dili_v1\",\"cell_viability\",\"uM\",\"__unknown__\",\"MTT reduction cell viability assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 63, "bucket_total_record_count": 75, "bucket_train_parent_count": 63, "bucket_train_record_count": 75, "calibration_sample_standard_deviation": 26.73682510816991, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 26.73682510816991, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 394.0686763888889, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 63, "ratio_gate_record_count": 75, "ratio_gate_repeated_parent_count": 8, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 12, "train_parent_count": 63, "train_record_count": 75, "unweighted_parent_mean_variance": 643.5009170819822, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"uM\",\"__unknown__\",\"MTT reduction cell viability assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.6123824627567461 }, "[\"dili_v1\",\"cell_viability\",\"uM\",\"__unknown__\",\"antiproliferative/cytotoxicity IC50\",\"human\",\"L3\"]": { "bucket_total_parent_count": 16, "bucket_total_record_count": 21, "bucket_train_parent_count": 16, "bucket_train_record_count": 21, "calibration_sample_standard_deviation": 6.881854703632209, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.8206971173942648, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.32809243168896574, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 16, "ratio_gate_record_count": 21, "ratio_gate_repeated_parent_count": 3, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 5, "train_parent_count": 16, "train_record_count": 21, "unweighted_parent_mean_variance": 0.7045395392410638, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"uM\",\"__unknown__\",\"antiproliferative/cytotoxicity IC50\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.4656834903011828 }, "[\"dili_v1\",\"cell_viability\",\"uM\",\"__unknown__\",\"cell proliferation/cytotoxicity assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 25, "bucket_total_record_count": 25, "bucket_train_parent_count": 25, "bucket_train_record_count": 25, "calibration_sample_standard_deviation": 7.528011712265066, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 7.528011712265066, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": null, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 25, "ratio_gate_record_count": 25, "ratio_gate_repeated_parent_count": 0, "ratio_gate_status": "undefined_allowed", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 0, "train_parent_count": 25, "train_record_count": 25, "unweighted_parent_mean_variance": 56.67096034, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"uM\",\"__unknown__\",\"cell proliferation/cytotoxicity assay\",\"human\"]", "within_to_parent_mean_variance_ratio": null }, "[\"dili_v1\",\"cell_viability\",\"uM\",\"__unknown__\",\"cell viability (unspecified method)\",\"human\",\"L3\"]": { "bucket_total_parent_count": 18, "bucket_total_record_count": 19, "bucket_train_parent_count": 18, "bucket_train_record_count": 19, "calibration_sample_standard_deviation": 15709.416357783131, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 15709.416357783131, "logit_geometry_sd_inflation": 684.7586967890443, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 6.160049999999993, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 19, "ratio_gate_record_count": 20, "ratio_gate_repeated_parent_count": 1, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 1, "ratio_gate_within_df": 1, "train_parent_count": 18, "train_record_count": 19, "unweighted_parent_mean_variance": 246599856.40201798, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"uM\",\"__unknown__\",\"cell viability (unspecified method)\",\"human\"]", "within_to_parent_mean_variance_ratio": 2.4979941553403044e-08 }, "[\"dili_v1\",\"cell_viability\",\"uM\",\"__unknown__\",\"cell viability/cytotoxicity assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 13, "bucket_total_record_count": 14, "bucket_train_parent_count": 12, "bucket_train_record_count": 13, "calibration_sample_standard_deviation": 166.37606456387812, "calibration_scope": "whole_bucket_ood.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 166.37606456387812, "logit_geometry_sd_inflation": 3.579191567105308, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.050244499999999914, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 13, "ratio_gate_record_count": 14, "ratio_gate_repeated_parent_count": 1, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 1, "train_parent_count": 13, "train_record_count": 14, "unweighted_parent_mean_variance": 29368.892096647436, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"uM\",\"__unknown__\",\"cell viability/cytotoxicity assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 1.7108067895327758e-06 }, "[\"dili_v1\",\"cell_viability\",\"ug_per_ml\",\"__unknown__\",\"MTT cell viability assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 47, "bucket_total_record_count": 121, "bucket_train_parent_count": 45, "bucket_train_record_count": 116, "calibration_sample_standard_deviation": 179.82563788136414, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.9478943948212648, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.18646781510276625, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 47, "ratio_gate_record_count": 121, "ratio_gate_repeated_parent_count": 21, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 74, "train_parent_count": 45, "train_record_count": 116, "unweighted_parent_mean_variance": 0.6205798519620845, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"ug_per_ml\",\"__unknown__\",\"MTT cell viability assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.3004735240972001 }, "[\"dili_v1\",\"cell_viability\",\"ug_per_ml\",\"__unknown__\",\"MTT reduction cell viability assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 32, "bucket_total_record_count": 51, "bucket_train_parent_count": 26, "bucket_train_record_count": 45, "calibration_sample_standard_deviation": 26.154966131335616, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 26.154966131335616, "logit_geometry_sd_inflation": 1.5287920381370785, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 41.72084054736842, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 33, "ratio_gate_record_count": 52, "ratio_gate_repeated_parent_count": 5, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 1, "ratio_gate_within_df": 19, "train_parent_count": 26, "train_record_count": 45, "unweighted_parent_mean_variance": 808.4431567180051, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"ug_per_ml\",\"__unknown__\",\"MTT reduction cell viability assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.051606399535547264 }, "[\"dili_v1\",\"cell_viability\",\"ug_per_ml\",\"__unknown__\",\"MTT reduction cell viability/metabolic activity assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 27, "bucket_total_record_count": 34, "bucket_train_parent_count": 27, "bucket_train_record_count": 34, "calibration_sample_standard_deviation": 30.141632183307472, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 30.141632183307472, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 418.87943810714285, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 28, "ratio_gate_record_count": 35, "ratio_gate_repeated_parent_count": 5, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 1, "ratio_gate_within_df": 7, "train_parent_count": 27, "train_record_count": 34, "unweighted_parent_mean_variance": 714.9618765815973, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"ug_per_ml\",\"__unknown__\",\"MTT reduction cell viability/metabolic activity assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.5858766066099986 }, "[\"dili_v1\",\"cell_viability\",\"ug_per_ml\",\"__unknown__\",\"cell viability (unspecified method)\",\"human\",\"L3\"]": { "bucket_total_parent_count": 23, "bucket_total_record_count": 42, "bucket_train_parent_count": 22, "bucket_train_record_count": 41, "calibration_sample_standard_deviation": 322.4447430417643, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 0.9289598952037788, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.3450892243507285, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 23, "ratio_gate_record_count": 42, "ratio_gate_repeated_parent_count": 9, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 19, "train_parent_count": 22, "train_record_count": 41, "unweighted_parent_mean_variance": 0.5458216674908772, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"ug_per_ml\",\"__unknown__\",\"cell viability (unspecified method)\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.632238045691904 }, "[\"dili_v1\",\"cell_viability\",\"ug_per_ml\",\"__unknown__\",\"cell viability/cytotoxicity assay\",\"human\",\"L3\"]": { "bucket_total_parent_count": 18, "bucket_total_record_count": 25, "bucket_train_parent_count": 16, "bucket_train_record_count": 22, "calibration_sample_standard_deviation": 134.23209254620645, "calibration_scope": "whole_bucket_ood.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 1.1096254459203367, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.2593014384072535, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 18, "ratio_gate_record_count": 25, "ratio_gate_repeated_parent_count": 3, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 7, "train_parent_count": 18, "train_record_count": 25, "unweighted_parent_mean_variance": 0.9498358541140267, "upstream_pair_bucket_key": "[\"dili_v1\",\"cell_viability\",\"ug_per_ml\",\"__unknown__\",\"cell viability/cytotoxicity assay\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.2729960521959036 }, "[\"dili_v1\",\"cellular_energy_or_atp\",\"\\u00b5M\",\"__unknown__\",\"ATP content\",\"human\",\"L5\"]": { "bucket_total_parent_count": 17, "bucket_total_record_count": 26, "bucket_train_parent_count": 15, "bucket_train_record_count": 24, "calibration_sample_standard_deviation": 197.63336169872886, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L5", "logit_calibration_sample_standard_deviation": 1.081237818798408, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.04701545030049069, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 19, "ratio_gate_record_count": 29, "ratio_gate_repeated_parent_count": 9, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 3, "ratio_gate_within_df": 10, "train_parent_count": 15, "train_record_count": 24, "unweighted_parent_mean_variance": 0.8540480654422872, "upstream_pair_bucket_key": "[\"dili_v1\",\"cellular_energy_or_atp\",\"\u00b5M\",\"__unknown__\",\"ATP content\",\"human\"]", "within_to_parent_mean_variance_ratio": 0.055050122121806724 }, "[\"dili_v1\",\"cellular_energy_or_atp\",\"nmol_per_million_cells\",\"__unknown__\",\"ATP content\",\"rat\",\"L5\"]": { "bucket_total_parent_count": 17, "bucket_total_record_count": 24, "bucket_train_parent_count": 16, "bucket_train_record_count": 23, "calibration_sample_standard_deviation": 8.583962422422713, "calibration_scope": "whole_bucket_ood.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L5", "logit_calibration_sample_standard_deviation": 8.583962422422713, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 15.815714285714282, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 17, "ratio_gate_record_count": 24, "ratio_gate_repeated_parent_count": 5, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 7, "train_parent_count": 17, "train_record_count": 24, "unweighted_parent_mean_variance": 61.88718602941176, "upstream_pair_bucket_key": "[\"dili_v1\",\"cellular_energy_or_atp\",\"nmol_per_million_cells\",\"__unknown__\",\"ATP content\",\"rat\"]", "within_to_parent_mean_variance_ratio": 0.2555571726624942 }, "[\"dili_v1\",\"membrane_integrity_or_necrosis\",\"\\u00b5M\",\"__unknown__\",\"LDH release\",\"rat\",\"L3\"]": { "bucket_total_parent_count": 17, "bucket_total_record_count": 21, "bucket_train_parent_count": 16, "bucket_train_record_count": 20, "calibration_sample_standard_deviation": 12711.068191480848, "calibration_scope": "whole_bucket_ood.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L3", "logit_calibration_sample_standard_deviation": 1.0015083126851643, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.5547621264284822, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 17, "ratio_gate_record_count": 21, "ratio_gate_repeated_parent_count": 4, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 4, "train_parent_count": 17, "train_record_count": 21, "unweighted_parent_mean_variance": 1.0124314021695575, "upstream_pair_bucket_key": "[\"dili_v1\",\"membrane_integrity_or_necrosis\",\"\u00b5M\",\"__unknown__\",\"LDH release\",\"rat\"]", "within_to_parent_mean_variance_ratio": 0.5479503354396875 }, "[\"dili_v2\",\"mitochondrial_fatty_acid_oxidation\",\"uM\",\"__unknown__\",\"palmitoyl-CoA beta-oxidation\",\"rat\",\"L5\"]": { "bucket_total_parent_count": 22, "bucket_total_record_count": 22, "bucket_train_parent_count": 22, "bucket_train_record_count": 22, "calibration_sample_standard_deviation": 7.7874471084902055, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L5", "logit_calibration_sample_standard_deviation": 7.7874471084902055, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": null, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 22, "ratio_gate_record_count": 22, "ratio_gate_repeated_parent_count": 0, "ratio_gate_status": "undefined_allowed", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 0, "train_parent_count": 22, "train_record_count": 22, "unweighted_parent_mean_variance": 60.644332467532465, "upstream_pair_bucket_key": "[\"dili_v2\",\"mitochondrial_fatty_acid_oxidation\",\"uM\",\"__unknown__\",\"palmitoyl-CoA beta-oxidation\",\"rat\"]", "within_to_parent_mean_variance_ratio": null }, "[\"dili_v3\",\"bile_acid_accumulation_or_pool\",\"\\u00b5mol/L\",\"__unknown__\",\"serum total bile acids\",\"L4\"]": { "bucket_total_parent_count": 20, "bucket_total_record_count": 29, "bucket_train_parent_count": 18, "bucket_train_record_count": 26, "calibration_sample_standard_deviation": 94.93623826008364, "calibration_scope": "whole_bucket_ood.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L4", "logit_calibration_sample_standard_deviation": 0.5303566919864915, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.13991731861476814, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 25, "ratio_gate_record_count": 51, "ratio_gate_repeated_parent_count": 9, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 22, "ratio_gate_within_df": 26, "train_parent_count": 20, "train_record_count": 29, "unweighted_parent_mean_variance": 0.2920903559405915, "upstream_pair_bucket_key": "[\"dili_v3\",\"bile_acid_accumulation_or_pool\",\"\u00b5mol/L\",\"__unknown__\",\"serum total bile acids\"]", "within_to_parent_mean_variance_ratio": 0.47902067209376137 }, "[\"dili_v3\",\"biliary_secretion_or_bile_flow\",\"\\u00b5L/\\u00b5mol\",\"__unknown__\",\"bile flow\",\"L4\"]": { "bucket_total_parent_count": 12, "bucket_total_record_count": 16, "bucket_train_parent_count": 11, "bucket_train_record_count": 15, "calibration_sample_standard_deviation": 18.65649163160105, "calibration_scope": "whole_bucket_ood.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L4", "logit_calibration_sample_standard_deviation": 18.65649163160105, "logit_geometry_sd_inflation": 1.6522012359520586, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 204.0231378125, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 20, "ratio_gate_record_count": 36, "ratio_gate_repeated_parent_count": 7, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 20, "ratio_gate_within_df": 16, "train_parent_count": 12, "train_record_count": 16, "unweighted_parent_mean_variance": 424.6201636967105, "upstream_pair_bucket_key": "[\"dili_v3\",\"biliary_secretion_or_bile_flow\",\"\u00b5L/\u00b5mol\",\"__unknown__\",\"bile flow\"]", "within_to_parent_mean_variance_ratio": 0.48048386594807524 }, "[\"dili_v3\",\"biliary_secretion_or_bile_flow\",\"\\u00b5L/min/100 g body weight\",\"__unknown__\",\"bile flow\",\"L4\"]": { "bucket_total_parent_count": 14, "bucket_total_record_count": 17, "bucket_train_parent_count": 14, "bucket_train_record_count": 17, "calibration_sample_standard_deviation": 5.584500017116704, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L4", "logit_calibration_sample_standard_deviation": 5.584500017116704, "logit_geometry_sd_inflation": 1.252798300765317, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 9.074020833333334, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 16, "ratio_gate_record_count": 22, "ratio_gate_repeated_parent_count": 4, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 5, "ratio_gate_within_df": 6, "train_parent_count": 14, "train_record_count": 17, "unweighted_parent_mean_variance": 30.391236015624997, "upstream_pair_bucket_key": "[\"dili_v3\",\"biliary_secretion_or_bile_flow\",\"\u00b5L/min/100 g body weight\",\"__unknown__\",\"bile flow\"]", "within_to_parent_mean_variance_ratio": 0.2985736028856517 }, "[\"dili_v3\",\"biliary_secretion_or_bile_flow\",\"\\u00b5L/min/100 g\",\"__unknown__\",\"bile flow\",\"L4\"]": { "bucket_total_parent_count": 11, "bucket_total_record_count": 21, "bucket_train_parent_count": 10, "bucket_train_record_count": 15, "calibration_sample_standard_deviation": 9.325016941131043, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L4", "logit_calibration_sample_standard_deviation": 9.325016941131043, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 5.170889393939394, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 16, "ratio_gate_record_count": 27, "ratio_gate_repeated_parent_count": 5, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 6, "ratio_gate_within_df": 11, "train_parent_count": 10, "train_record_count": 15, "unweighted_parent_mean_variance": 62.94366961805556, "upstream_pair_bucket_key": "[\"dili_v3\",\"biliary_secretion_or_bile_flow\",\"\u00b5L/min/100 g\",\"__unknown__\",\"bile flow\"]", "within_to_parent_mean_variance_ratio": 0.08215106340822732 }, "[\"dili_v3\",\"biliary_secretion_or_bile_flow\",\"\\u00b5l/min/g liver\",\"__unknown__\",\"bile flow\",\"L4\"]": { "bucket_total_parent_count": 19, "bucket_total_record_count": 19, "bucket_train_parent_count": 18, "bucket_train_record_count": 18, "calibration_sample_standard_deviation": 1.241903839352641, "calibration_scope": "whole_bucket_ood.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L4", "logit_calibration_sample_standard_deviation": 1.241903839352641, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.9139861111111112, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 26, "ratio_gate_record_count": 35, "ratio_gate_repeated_parent_count": 5, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 16, "ratio_gate_within_df": 9, "train_parent_count": 19, "train_record_count": 19, "unweighted_parent_mean_variance": 1.4598620096153847, "upstream_pair_bucket_key": "[\"dili_v3\",\"biliary_secretion_or_bile_flow\",\"\u00b5l/min/g liver\",\"__unknown__\",\"bile flow\"]", "within_to_parent_mean_variance_ratio": 0.6260770573459268 }, "[\"dili_v4\",\"cell_viability\",\"U/L\",\"__unknown__\",\"serum AST activity\",\"L2\"]": { "bucket_total_parent_count": 15, "bucket_total_record_count": 22, "bucket_train_parent_count": 15, "bucket_train_record_count": 22, "calibration_sample_standard_deviation": 668.5726810573979, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L2", "logit_calibration_sample_standard_deviation": 668.5726810573979, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 69776.2770969697, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 17, "ratio_gate_record_count": 28, "ratio_gate_repeated_parent_count": 7, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 6, "ratio_gate_within_df": 11, "train_parent_count": 15, "train_record_count": 22, "unweighted_parent_mean_variance": 397793.3519656046, "upstream_pair_bucket_key": "[\"dili_v4\",\"cell_viability\",\"U/L\",\"__unknown__\",\"serum AST activity\"]", "within_to_parent_mean_variance_ratio": 0.17540835399130286 }, "[\"dili_v4\",\"cell_viability\",\"U/L\",\"__unknown__\",\"serum/plasma ALT activity\",\"L2\"]": { "bucket_total_parent_count": 23, "bucket_total_record_count": 37, "bucket_train_parent_count": 23, "bucket_train_record_count": 37, "calibration_sample_standard_deviation": 4035.2568894650035, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L2", "logit_calibration_sample_standard_deviation": 0.731344242508505, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.18917807881694298, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 24, "ratio_gate_record_count": 38, "ratio_gate_repeated_parent_count": 6, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 1, "ratio_gate_within_df": 14, "train_parent_count": 23, "train_record_count": 37, "unweighted_parent_mean_variance": 0.5891539260456531, "upstream_pair_bucket_key": "[\"dili_v4\",\"cell_viability\",\"U/L\",\"__unknown__\",\"serum/plasma ALT activity\"]", "within_to_parent_mean_variance_ratio": 0.3211012783818464 }, "[\"dili_v4\",\"cell_viability\",\"percent\",\"__unknown__\",\"Survival in in vivo mouse D-GalN/LPS-induced acute liver failure/injury model\",\"L2\"]": { "bucket_total_parent_count": 17, "bucket_total_record_count": 23, "bucket_train_parent_count": 16, "bucket_train_record_count": 22, "calibration_sample_standard_deviation": 24.381307838931836, "calibration_scope": "whole_bucket_ood.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L2", "logit_calibration_sample_standard_deviation": 24.381307838931836, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 313.4375, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 17, "ratio_gate_record_count": 23, "ratio_gate_repeated_parent_count": 4, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 6, "train_parent_count": 17, "train_record_count": 23, "unweighted_parent_mean_variance": 556.7131617647059, "upstream_pair_bucket_key": "[\"dili_v4\",\"cell_viability\",\"percent\",\"__unknown__\",\"Survival in in vivo mouse D-GalN/LPS-induced acute liver failure/injury model\"]", "within_to_parent_mean_variance_ratio": 0.5630143519625892 }, "[\"dili_v4\",\"cytokine_chemokine_or_eicosanoid\",\"pg/mL\",\"__unknown__\",\"Serum IL-6 concentration\",\"L2\"]": { "bucket_total_parent_count": 14, "bucket_total_record_count": 20, "bucket_train_parent_count": 14, "bucket_train_record_count": 20, "calibration_sample_standard_deviation": 323.8561326280382, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L2", "logit_calibration_sample_standard_deviation": 323.8561326280382, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 13396.100952777777, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 14, "ratio_gate_record_count": 20, "ratio_gate_repeated_parent_count": 5, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 6, "train_parent_count": 14, "train_record_count": 20, "unweighted_parent_mean_variance": 85122.96242803724, "upstream_pair_bucket_key": "[\"dili_v4\",\"cytokine_chemokine_or_eicosanoid\",\"pg/mL\",\"__unknown__\",\"Serum IL-6 concentration\"]", "within_to_parent_mean_variance_ratio": 0.15737352848948144 }, "[\"dili_v4\",\"cytokine_chemokine_or_eicosanoid\",\"pg/mL\",\"__unknown__\",\"Serum IL-6 concentration\",\"L6\"]": { "bucket_total_parent_count": 12, "bucket_total_record_count": 16, "bucket_train_parent_count": 12, "bucket_train_record_count": 16, "calibration_sample_standard_deviation": 202.42802516367803, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L6", "logit_calibration_sample_standard_deviation": 202.42802516367803, "logit_geometry_sd_inflation": 1.2546671185666989, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 23003.177929166668, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 12, "ratio_gate_record_count": 16, "ratio_gate_repeated_parent_count": 3, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 4, "train_parent_count": 12, "train_record_count": 16, "unweighted_parent_mean_variance": 40797.085358312295, "upstream_pair_bucket_key": "[\"dili_v4\",\"cytokine_chemokine_or_eicosanoid\",\"pg/mL\",\"__unknown__\",\"Serum IL-6 concentration\"]", "within_to_parent_mean_variance_ratio": 0.5638436600834239 }, "[\"dili_v4\",\"cytokine_chemokine_or_eicosanoid\",\"pg/mL\",\"__unknown__\",\"serum IL-1\\u03b2 level\",\"L2\"]": { "bucket_total_parent_count": 8, "bucket_total_record_count": 12, "bucket_train_parent_count": 8, "bucket_train_record_count": 12, "calibration_sample_standard_deviation": 284.11982627240326, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L2", "logit_calibration_sample_standard_deviation": 284.11982627240326, "logit_geometry_sd_inflation": 18.55082878280382, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 19.520779166666664, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 8, "ratio_gate_record_count": 12, "ratio_gate_repeated_parent_count": 3, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 4, "train_parent_count": 8, "train_record_count": 12, "unweighted_parent_mean_variance": 121515.12414796627, "upstream_pair_bucket_key": "[\"dili_v4\",\"cytokine_chemokine_or_eicosanoid\",\"pg/mL\",\"__unknown__\",\"serum IL-1\u03b2 level\"]", "within_to_parent_mean_variance_ratio": 0.00016064485226461724 }, "[\"dili_v4\",\"cytokine_chemokine_or_eicosanoid\",\"pg/mL\",\"__unknown__\",\"serum TNF-alpha concentration\",\"L2\"]": { "bucket_total_parent_count": 21, "bucket_total_record_count": 30, "bucket_train_parent_count": 21, "bucket_train_record_count": 30, "calibration_sample_standard_deviation": 103.10767013474842, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L2", "logit_calibration_sample_standard_deviation": 103.10767013474842, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 6220.058574074073, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 21, "ratio_gate_record_count": 30, "ratio_gate_repeated_parent_count": 7, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 9, "train_parent_count": 21, "train_record_count": 30, "unweighted_parent_mean_variance": 10123.15776308148, "upstream_pair_bucket_key": "[\"dili_v4\",\"cytokine_chemokine_or_eicosanoid\",\"pg/mL\",\"__unknown__\",\"serum TNF-alpha concentration\"]", "within_to_parent_mean_variance_ratio": 0.6144385694311941 }, "[\"dili_v4\",\"cytokine_chemokine_or_eicosanoid\",\"pg/mL\",\"__unknown__\",\"serum TNF-alpha concentration\",\"L6\"]": { "bucket_total_parent_count": 20, "bucket_total_record_count": 23, "bucket_train_parent_count": 20, "bucket_train_record_count": 23, "calibration_sample_standard_deviation": 456.3117483157629, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L6", "logit_calibration_sample_standard_deviation": 456.3117483157629, "logit_geometry_sd_inflation": 1.6491019040141417, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 130.66868333333335, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 20, "ratio_gate_record_count": 23, "ratio_gate_repeated_parent_count": 3, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 3, "train_parent_count": 20, "train_record_count": 23, "unweighted_parent_mean_variance": 217105.33147756578, "upstream_pair_bucket_key": "[\"dili_v4\",\"cytokine_chemokine_or_eicosanoid\",\"pg/mL\",\"__unknown__\",\"serum TNF-alpha concentration\"]", "within_to_parent_mean_variance_ratio": 0.0006018676853490159 }, "[\"dili_v5\",\"antioxidant_system\",\"U/mL\",\"__unknown__\",\"SOD activity\",\"L7\"]": { "bucket_total_parent_count": 18, "bucket_total_record_count": 26, "bucket_train_parent_count": 18, "bucket_train_record_count": 26, "calibration_sample_standard_deviation": 41.54466024190575, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 41.54466024190575, "logit_geometry_sd_inflation": 1.5205981476563977, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 74.90877083333332, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 18, "ratio_gate_record_count": 26, "ratio_gate_repeated_parent_count": 6, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 8, "train_parent_count": 18, "train_record_count": 26, "unweighted_parent_mean_variance": 1439.0697163035586, "upstream_pair_bucket_key": "[\"dili_v5\",\"antioxidant_system\",\"U/mL\",\"__unknown__\",\"SOD activity\"]", "within_to_parent_mean_variance_ratio": 0.05205360795566349 }, "[\"dili_v5\",\"antioxidant_system\",\"U/mg protein\",\"__unknown__\",\"SOD activity assay\",\"L7\"]": { "bucket_total_parent_count": 16, "bucket_total_record_count": 33, "bucket_train_parent_count": 16, "bucket_train_record_count": 33, "calibration_sample_standard_deviation": 45.364720081260685, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 45.364720081260685, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 73.30049542483661, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 16, "ratio_gate_record_count": 33, "ratio_gate_repeated_parent_count": 4, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 17, "train_parent_count": 16, "train_record_count": 33, "unweighted_parent_mean_variance": 1555.7575437407406, "upstream_pair_bucket_key": "[\"dili_v5\",\"antioxidant_system\",\"U/mg protein\",\"__unknown__\",\"SOD activity assay\"]", "within_to_parent_mean_variance_ratio": 0.047115629115697076 }, "[\"dili_v5\",\"antioxidant_system\",\"U/mg protein\",\"__unknown__\",\"SOD activity\",\"L7\"]": { "bucket_total_parent_count": 62, "bucket_total_record_count": 109, "bucket_train_parent_count": 61, "bucket_train_record_count": 108, "calibration_sample_standard_deviation": 77.76910236154662, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 0.7543253767306254, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.20434328613122366, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 62, "ratio_gate_record_count": 109, "ratio_gate_repeated_parent_count": 22, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 47, "train_parent_count": 61, "train_record_count": 108, "unweighted_parent_mean_variance": 0.5532243472151875, "upstream_pair_bucket_key": "[\"dili_v5\",\"antioxidant_system\",\"U/mg protein\",\"__unknown__\",\"SOD activity\"]", "within_to_parent_mean_variance_ratio": 0.3693678471669655 }, "[\"dili_v5\",\"antioxidant_system\",\"U/mg protein\",\"__unknown__\",\"glutathione peroxidase (GPx) activity\",\"L7\"]": { "bucket_total_parent_count": 29, "bucket_total_record_count": 62, "bucket_train_parent_count": 29, "bucket_train_record_count": 62, "calibration_sample_standard_deviation": 269.8869490560181, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 0.8727429014553687, "logit_geometry_sd_inflation": 1.0990111116394259, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.03371969450621433, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 29, "ratio_gate_record_count": 62, "ratio_gate_repeated_parent_count": 14, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 33, "train_parent_count": 29, "train_record_count": 62, "unweighted_parent_mean_variance": 0.8418100536203842, "upstream_pair_bucket_key": "[\"dili_v5\",\"antioxidant_system\",\"U/mg protein\",\"__unknown__\",\"glutathione peroxidase (GPx) activity\"]", "within_to_parent_mean_variance_ratio": 0.04005617937347691 }, "[\"dili_v5\",\"antioxidant_system\",\"U/mg protein\",\"__unknown__\",\"superoxide dismutase (SOD) activity\",\"L7\"]": { "bucket_total_parent_count": 17, "bucket_total_record_count": 32, "bucket_train_parent_count": 17, "bucket_train_record_count": 32, "calibration_sample_standard_deviation": 107.55199087223185, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 107.55199087223185, "logit_geometry_sd_inflation": 1.3206862365022187, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 564.9354588888888, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 17, "ratio_gate_record_count": 32, "ratio_gate_repeated_parent_count": 10, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 15, "train_parent_count": 17, "train_record_count": 32, "unweighted_parent_mean_variance": 16303.616881566177, "upstream_pair_bucket_key": "[\"dili_v5\",\"antioxidant_system\",\"U/mg protein\",\"__unknown__\",\"superoxide dismutase (SOD) activity\"]", "within_to_parent_mean_variance_ratio": 0.03465092825676233 }, "[\"dili_v5\",\"antioxidant_system\",\"U/mgprot\",\"__unknown__\",\"SOD activity\",\"L7\"]": { "bucket_total_parent_count": 23, "bucket_total_record_count": 43, "bucket_train_parent_count": 22, "bucket_train_record_count": 42, "calibration_sample_standard_deviation": 52.35969352680795, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 52.35969352680795, "logit_geometry_sd_inflation": 1.1847812747957904, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 465.87808393333336, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 24, "ratio_gate_record_count": 44, "ratio_gate_repeated_parent_count": 10, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 1, "ratio_gate_within_df": 20, "train_parent_count": 22, "train_record_count": 42, "unweighted_parent_mean_variance": 2825.466630932166, "upstream_pair_bucket_key": "[\"dili_v5\",\"antioxidant_system\",\"U/mgprot\",\"__unknown__\",\"SOD activity\"]", "within_to_parent_mean_variance_ratio": 0.16488536046862914 }, "[\"dili_v5\",\"antioxidant_system\",\"nmol/min/mg protein\",\"__unknown__\",\"glutathione peroxidase (GPx) activity\",\"L7\"]": { "bucket_total_parent_count": 23, "bucket_total_record_count": 30, "bucket_train_parent_count": 23, "bucket_train_record_count": 30, "calibration_sample_standard_deviation": 94.67673162598776, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 94.67673162598776, "logit_geometry_sd_inflation": 1.6407585273770802, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 45.01863571428567, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 23, "ratio_gate_record_count": 30, "ratio_gate_repeated_parent_count": 7, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 7, "train_parent_count": 23, "train_record_count": 30, "unweighted_parent_mean_variance": 10954.368374209487, "upstream_pair_bucket_key": "[\"dili_v5\",\"antioxidant_system\",\"nmol/min/mg protein\",\"__unknown__\",\"glutathione peroxidase (GPx) activity\"]", "within_to_parent_mean_variance_ratio": 0.004109651435520069 }, "[\"dili_v5\",\"glutathione_thiol_redox\",\"GSH/GSSG ratio\",\"__unknown__\",\"GSH/GSSG ratio\",\"L7\"]": { "bucket_total_parent_count": 42, "bucket_total_record_count": 72, "bucket_train_parent_count": 42, "bucket_train_record_count": 72, "calibration_sample_standard_deviation": 58.21953912340417, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 0.7003216680926765, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.2572026084652858, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 43, "ratio_gate_record_count": 74, "ratio_gate_repeated_parent_count": 20, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 2, "ratio_gate_within_df": 31, "train_parent_count": 42, "train_record_count": 72, "unweighted_parent_mean_variance": 0.4366552108568054, "upstream_pair_bucket_key": "[\"dili_v5\",\"glutathione_thiol_redox\",\"GSH/GSSG ratio\",\"__unknown__\",\"GSH/GSSG ratio\"]", "within_to_parent_mean_variance_ratio": 0.5890290601607674 }, "[\"dili_v5\",\"glutathione_thiol_redox\",\"mV\",\"__unknown__\",\"GSH/GSSG redox potential\",\"L7\"]": { "bucket_total_parent_count": 23, "bucket_total_record_count": 32, "bucket_train_parent_count": 23, "bucket_train_record_count": 32, "calibration_sample_standard_deviation": 68.65214326001445, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 68.65214326001445, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 1107.000740740741, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 23, "ratio_gate_record_count": 32, "ratio_gate_repeated_parent_count": 8, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 9, "train_parent_count": 23, "train_record_count": 32, "unweighted_parent_mean_variance": 4679.835015371103, "upstream_pair_bucket_key": "[\"dili_v5\",\"glutathione_thiol_redox\",\"mV\",\"__unknown__\",\"GSH/GSSG redox potential\"]", "within_to_parent_mean_variance_ratio": 0.23654695883610288 }, "[\"dili_v5\",\"glutathione_thiol_redox\",\"nmol/10^6 cells\",\"__unknown__\",\"cellular GSH content\",\"L7\"]": { "bucket_total_parent_count": 26, "bucket_total_record_count": 39, "bucket_train_parent_count": 26, "bucket_train_record_count": 39, "calibration_sample_standard_deviation": 14.862498282445031, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 14.862498282445031, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 19.559224358974355, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 27, "ratio_gate_record_count": 40, "ratio_gate_repeated_parent_count": 6, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 1, "ratio_gate_within_df": 13, "train_parent_count": 26, "train_record_count": 39, "unweighted_parent_mean_variance": 215.1290049461855, "upstream_pair_bucket_key": "[\"dili_v5\",\"glutathione_thiol_redox\",\"nmol/10^6 cells\",\"__unknown__\",\"cellular GSH content\"]", "within_to_parent_mean_variance_ratio": 0.0909185833117533 }, "[\"dili_v5\",\"glutathione_thiol_redox\",\"nmol/mg protein\",\"__unknown__\",\"GSH content normalized to protein\",\"L7\"]": { "bucket_total_parent_count": 29, "bucket_total_record_count": 49, "bucket_train_parent_count": 29, "bucket_train_record_count": 49, "calibration_sample_standard_deviation": 91.19087800856393, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 0.5906176705457739, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.008300588748809113, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 29, "ratio_gate_record_count": 49, "ratio_gate_repeated_parent_count": 13, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 20, "train_parent_count": 29, "train_record_count": 49, "unweighted_parent_mean_variance": 0.49996920745424916, "upstream_pair_bucket_key": "[\"dili_v5\",\"glutathione_thiol_redox\",\"nmol/mg protein\",\"__unknown__\",\"GSH content normalized to protein\"]", "within_to_parent_mean_variance_ratio": 0.016602199945621007 }, "[\"dili_v5\",\"glutathione_thiol_redox\",\"nmol/mg protein\",\"__unknown__\",\"cellular GSH content\",\"L7\"]": { "bucket_total_parent_count": 16, "bucket_total_record_count": 25, "bucket_train_parent_count": 16, "bucket_train_record_count": 25, "calibration_sample_standard_deviation": 56.0958302817598, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 56.0958302817598, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 557.6362962962963, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 16, "ratio_gate_record_count": 25, "ratio_gate_repeated_parent_count": 6, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 9, "train_parent_count": 16, "train_record_count": 25, "unweighted_parent_mean_variance": 4216.0179873611105, "upstream_pair_bucket_key": "[\"dili_v5\",\"glutathione_thiol_redox\",\"nmol/mg protein\",\"__unknown__\",\"cellular GSH content\"]", "within_to_parent_mean_variance_ratio": 0.13226610938757688 }, "[\"dili_v5\",\"glutathione_thiol_redox\",\"nmol/mg protein\",\"__unknown__\",\"reduced glutathione (GSH) level\",\"L7\"]": { "bucket_total_parent_count": 17, "bucket_total_record_count": 23, "bucket_train_parent_count": 17, "bucket_train_record_count": 23, "calibration_sample_standard_deviation": 24.926196388602133, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 24.926196388602133, "logit_geometry_sd_inflation": 1.7393674537767518, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 43.12157500000001, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 17, "ratio_gate_record_count": 23, "ratio_gate_repeated_parent_count": 5, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 6, "train_parent_count": 17, "train_record_count": 23, "unweighted_parent_mean_variance": 629.02333125, "upstream_pair_bucket_key": "[\"dili_v5\",\"glutathione_thiol_redox\",\"nmol/mg protein\",\"__unknown__\",\"reduced glutathione (GSH) level\"]", "within_to_parent_mean_variance_ratio": 0.06855322029837667 }, "[\"dili_v5\",\"glutathione_thiol_redox\",\"ratio (unitless)\",\"__unknown__\",\"GSH/GSSG ratio\",\"L7\"]": { "bucket_total_parent_count": 15, "bucket_total_record_count": 18, "bucket_train_parent_count": 14, "bucket_train_record_count": 15, "calibration_sample_standard_deviation": 11.061027668574349, "calibration_scope": "whole_bucket_ood.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 11.061027668574349, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 60.77715555555554, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 15, "ratio_gate_record_count": 18, "ratio_gate_repeated_parent_count": 2, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 3, "train_parent_count": 15, "train_record_count": 18, "unweighted_parent_mean_variance": 124.71782595978834, "upstream_pair_bucket_key": "[\"dili_v5\",\"glutathione_thiol_redox\",\"ratio (unitless)\",\"__unknown__\",\"GSH/GSSG ratio\"]", "within_to_parent_mean_variance_ratio": 0.4873173108000726 }, "[\"dili_v5\",\"lipid_peroxidation\",\"nmol/mg protein\",\"__unknown__\",\"MDA level\",\"L7\"]": { "bucket_total_parent_count": 24, "bucket_total_record_count": 41, "bucket_train_parent_count": 24, "bucket_train_record_count": 41, "calibration_sample_standard_deviation": 2.2906737479423374, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 2.2906737479423374, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.833956862745098, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 24, "ratio_gate_record_count": 41, "ratio_gate_repeated_parent_count": 9, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 17, "train_parent_count": 24, "train_record_count": 41, "unweighted_parent_mean_variance": 5.688636936392914, "upstream_pair_bucket_key": "[\"dili_v5\",\"lipid_peroxidation\",\"nmol/mg protein\",\"__unknown__\",\"MDA level\"]", "within_to_parent_mean_variance_ratio": 0.14660047249805652 }, "[\"dili_v5\",\"lipid_peroxidation\",\"nmol/mg protein\",\"__unknown__\",\"MDA measurement\",\"L7\"]": { "bucket_total_parent_count": 26, "bucket_total_record_count": 46, "bucket_train_parent_count": 26, "bucket_train_record_count": 46, "calibration_sample_standard_deviation": 21.16638358153733, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 0.734157768013081, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "log10", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.14103513186342026, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 26, "ratio_gate_record_count": 46, "ratio_gate_repeated_parent_count": 12, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 20, "train_parent_count": 26, "train_record_count": 46, "unweighted_parent_mean_variance": 0.43857476349481717, "upstream_pair_bucket_key": "[\"dili_v5\",\"lipid_peroxidation\",\"nmol/mg protein\",\"__unknown__\",\"MDA measurement\"]", "within_to_parent_mean_variance_ratio": 0.3215760312781584 }, "[\"dili_v5\",\"lipid_peroxidation\",\"nmol/mg protein\",\"__unknown__\",\"TBARS assay\",\"L7\"]": { "bucket_total_parent_count": 17, "bucket_total_record_count": 32, "bucket_train_parent_count": 17, "bucket_train_record_count": 32, "calibration_sample_standard_deviation": 3.8707330449726896, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 3.8707330449726896, "logit_geometry_sd_inflation": 1.8445611114447915, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 0.8324331111111111, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 17, "ratio_gate_record_count": 32, "ratio_gate_repeated_parent_count": 8, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 15, "train_parent_count": 17, "train_record_count": 32, "unweighted_parent_mean_variance": 21.140455312908497, "upstream_pair_bucket_key": "[\"dili_v5\",\"lipid_peroxidation\",\"nmol/mg protein\",\"__unknown__\",\"TBARS assay\"]", "within_to_parent_mean_variance_ratio": 0.03937630948765905 }, "[\"dili_v5\",\"reactive_species\",\"FI units\",\"__unknown__\",\"cellular ROS assay in hepatocytes (fluorescence intensity units)\",\"L7\"]": { "bucket_total_parent_count": 17, "bucket_total_record_count": 41, "bucket_train_parent_count": 17, "bucket_train_record_count": 41, "calibration_sample_standard_deviation": 73.52127616398187, "calibration_scope": "train_exact_bucket.v27_safety", "calibration_standard_deviation_ddof": 1, "level": "L7", "logit_calibration_sample_standard_deviation": 73.52127616398187, "logit_geometry_sd_inflation": 1.0, "logit_geometry_transform": "identity", "measurement_kind": "continuous", "pooled_within_parent_variance": 686.2840277777777, "ratio_gate_fit_split": "train_validation_and_test_gate", "ratio_gate_maximum": 0.65, "ratio_gate_parent_count": 17, "ratio_gate_record_count": 41, "ratio_gate_repeated_parent_count": 7, "ratio_gate_status": "pass", "ratio_gate_test_record_count": 0, "ratio_gate_within_df": 24, "train_parent_count": 17, "train_record_count": 41, "unweighted_parent_mean_variance": 8304.57951388889, "upstream_pair_bucket_key": "[\"dili_v5\",\"reactive_species\",\"FI units\",\"__unknown__\",\"cellular ROS assay in hepatocytes (fluorescence intensity units)\"]", "within_to_parent_mean_variance_ratio": 0.08263922654121267 } }, "empirical_binary_targets": { "boundary_sd": 0.4, "fit_split": "train", "group_by": "level", "levels": {}, "schema_version": "assay_transfer_empirical_binary_targets.v24.level", "scope": "realized_continuous_training_pairs_pooled_across_sources_within_level", "temperature": 0.1 } }