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20860278 | Do viscid secretions have a role in nasal polyp formation? | pared histologic findings on light microscopy of viscid secretions found in association with nasal polyps with those found in patients with chronic sinusitis without polyposis (CSWP). The differences might further understanding of nasal polyp pathogenesis. |
20860277 | Bacteremia during adenoidectomy: a comparison of suction diathermy adenoid ablation and adenoid curettage. | Transient bacteremia is induced by adenoidectomy when the integrity of the nasopharyngeal membrane is broken. The aim of this study was to determine the incidence of bacteremia in patients undergoing adenoidectomy, to identify the causative organisms, and pare the incidences of bacteremia between the two techniques suc... |
20860279 | Bone marrow stem cell transplantation to olfactory epithelium. | We sought to develop a new therapeutic strategy for degeneration of olfactory receptor neurons (ORNs). |
20860280 | Age-specific size of the upper airway structures in children during development. | The purpose of this study was to establish the largest magnetic resonance imaging study so far, by including 292 cases in a prospective fashion, to investigate the normative values of the upper airway and surrounding tissues during development. |
20860281 | Rationale for targeting pepsin in the treatment of reflux disease. | We undertook to (1) obtain unequivocal evidence to confirm or rebut our initial observations that pepsin is taken up by hypopharyngeal epithelial cells by receptor-mediated endocytosis, (2) investigate whether uptake of pepsin at pH 7, in nonacidic refluxate, is of pathological significance, and 3) test our hypothesis ... |
20860282 | How does the absence or presence of subglottal medialization affect glottal airflow? | Our previous work has shown that the symmetric, smooth, convergent shape of the subglottis reduces turbulent airflow at the glottal entrance. Medialization thyroplasty may alter the glottal shape and is very likely to introduce some degree of glottal asymmetry, which could result in increased turbulence and a reduction... |
20860283 | In vitro and in vivo effects of D-allose: up-regulation of thioredoxin-interacting protein in head and neck cancer cells. | This study was aimed to investigate the relationship between the antiproliferative effects of D-allose and the up-regulation of thioredoxin-interacting protein (TXNIP) in head and neck cancer cells. |
20860298 | [Application of hair analysis of selected psychoactive substances for medico-legal purposes. Part I. Segmental hair analysis in cases of fatal opioids and amphetamines poisoning]. | The present experimental investigations were inspired by the necessity of standardizing the procedures and analytical methods employed in hair analysis aiming at a retrospective evaluation of ingestion of various xenobiotics. Thus, in keeping with the principal premises, the main objective of the study was development ... |
20860299 | [Analysis of taxus baccata alkaloids in biological samples with the use of chromatographic methods]. | The aim of the experiment was to develop a method of the identification of taxines (taxine B and isotaxine B) from Taxus leaves and its application to the analysis of biological samples collected from the deceased girl. The object of the investigation was the analysis of taxines in post-mortem samples collected from a ... |
20860300 | [Population genetics of 11 STR loci in the Upper Silesia population]. | The report present the results of population studies of 11 STR loci: D16S5539, D7S820, D13S317, CSF1PO, TPOX, TH01, F13A01, FESFPS, VWA, F13B, LPL originating from samples examined in Laboratory of Biological traces, Chair and Department of Forensic Medicine, Silesian Medical University. The examinations were performed... |
20860301 | [Application of the QIAamp DNA Investigator Kit and Prepfiler Forensic DNA Extraction Kit in genomic DNA extraction from skeletal remains]. | The report presents an application of the QIAamp DNA Investigator Kit and PrepFiler Forensic DNA Extraction Kit in genomic DNA extraction from post-mortem highly degraded skeletal remains. The analysis included 25 bone samples collected on autopsy. DNA extraction was performed in accordance with the QIAamp DNA Investig... |
20860302 | [Do contusions cause skin dysfunction?]. | Basing on the acquaintance with anatomy and physiology of the skin, the authors show that the emphasis placed on the functional aspect of human health, introduced by the Penal Code of 6 June 1997, should change the way contusions are subsumed under provisions of the aforementioned code. |
20860304 | [Mental state and the criminal responsibility--legal regulations and medical criteria in Poland and other countries]. | In contemporary civilized legal systems, sanity is a prerequisite for criminal responsibility of the perpetrator. Thus, insanity resulting from certain psychiatric and psychological disorders is a circumstance excluding the guilt. General assumptions of insanity criteria are close and similar in legal systems of the ma... |
20860306 | [Reconstruction of an air-gun injury track in the neck region--a case report]. | The authors present a case of an air-gun injury of the neck region with a foreign body left in situ. The DICOM files obtained during clinical CT examination puted tomography angiography) gave the opportunity for three-dimensional reconstructions of the location of the pellet, neighboring blood vessels and the bullet tr... |
20860303 | [Common paths of psychiatry and forensic medicine--history and evolution of insanity defense concept from antiquity to modern times]. | Forensic psychiatry and psychology were in their beginnings inseparably associated with the forensic medicine, constituting one of its related branches of knowledge. Progress and development of these disciplines, education and the practical application for the purposes of the law were a contribution of a several genera... |
20860305 | [A rare D19S433*7 variant in the paternity case with mutation]. | During a routine paternity casework performed with an automated genotyping using the AmpFISTR Identifiler kit, a lack of paternal allele segregation in D21S11 and off-ladder allele in D19S433 locus was observed. This raised suspicion of mutation because the other systems showed transmission of putative father's alleles... |
20860307 | [Postmortem CT examination in a case of alleged drowning--a case report]. | The authors present an analysis of postmortem CT examination in a case of drowning in fresh water of a young male. Both the results of conventional forensic autopsy and radiologic examination have pared. The analysis is illustrated by two-dimensional and three-dimensional reconstructions based on the DICOM files obtain... |
20860313 | Clinical manifestation of central nervous system tumor. | Tumors of the brain and spinal cord (central nervous system, CNS) are rare pared with other sites and other diseases that can affect the length of an individual's life. However, about 20,000 new cases of primary CNS tumors are diagnosed in the United States each year, not an insignificant number. The CNS is "locked" in... |
20860314 | Practical molecular diagnostics in neuropathology: making a tough job a little easier. | Neuropathology is a challenging field, in large part because of the consequential decisions that must be made with small biopsy material. This is especially true concerning the mon primary brain tumor, the infiltrative glioma. Fortunately, abundant research has identified specific molecular alterations that are charact... |
20860315 | Astrocytic neoplasms of the central nervous system and orbit: a morphologic perspective. | Astrocytic neoplasms constitute a highly diverse category of neoplasms in the central nervous system and the orbit that span from almost benign to highly malignant neoplasms. Most tumors in the former category are potentially cured by surgery alone, while the latter group of tumors do not respond to any form of current... |
20860316 | Infectious lesions mimicking central nervous system neoplasms. | Infections of the central nervous system (CNS) presenting as space-occupying lesions are not mon, particularly in developing countries. Most often, infective organisms gain entry into the CNS through the hematogenous route, seed the parenchyma, and cause tissue destruction. Subsequently, some form mass lesions in a man... |
20860317 | Oligodendroglial tumors: diagnostic and molecular pathology. | Oligodendroglial tumors, which pass pure oligodendroglioma and mixed oligoastrocytoma, represent the second mon glioma in adults after glioblastoma. They remain controversial neoplasms in the realm of surgical neuropathology. The early recognition of their more favorable prognosis and responsiveness to treatment pared ... |
20860319 | Building a case with hard facts. | Skill mix and staffing e under the spotlight in the final part of a Nursing Standard series in which RCN fellows consider nursing challenges. |
20860321 | Leadership challenge. | Nursing Standard's Power to Care campaign aims to boost the authority and status of ward sisters and charge nurses. Here we examine how nurses in Milton Keynes are pursuing its goals. |
20860324 | Implementation of the Mental Health Act 2007. | This article aims to contribute to an understanding of the Mental Health Act 2007, which came into force in November 2008. The article explains the link between the Mental Health Act, the Mental Health Act Code of Practice and mental health case law. It describes the guiding principles outlined in the Code of Practice,... |
20860332 | Appalachian women: health beliefs, self-care, and basic conditioning factors. | The purposes of this study were to: (a) describe the health beliefs and self-care of Appalachian women; and (b) describe the relationships among health beliefs, self-care, and the basic conditioning factors of Appalachian women. Orem's SCDNT was used as the theory for this study. This study used qualitative and quantit... |
20860331 | Strategies for providing cultural competent health care for Hmong Americans. | In the early 1980's the United States gave the Hmong preferred refugee status and a large number immigrated to the U.S. The Hmong refugees brought with them their language, social structure and customs, religious beliefs and rituals as well as their health care beliefs and practices. They were uprooted from munity and ... |
20860323 | Role of the ward sister: tensions, pressures and opportunities. | This article investigates the factors that have shaped the role and work experiences of ward sisters and charge nurses. The article considers how ward sisters make sense of the tensions between their clinical and managerial responsibilities and the contradictions inherent in different aspects of their role. It offers s... |
20860333 | Native Hawaiian attitudes of culturally sensitive healthcare provider traits and behaviors. | Provision of petent healthcare has been an area of increasing focus in research due to increased mobility of individuals and Increased ethnic and cultural diversity within the populations being served. A descriptive, exploratory design was used to investigate attitudes and perceptions of 61 Native Hawaiian adults regar... |
20860334 | Paradise Lost: how older adult Taiwanese immigrants make decisions about their living arrangements. | Understanding the process of making living arrangement decisions among older adult immigrants is essential to developing and optimizing health promotion strategies. The purpose of this study was to discover how older adult Taiwanese immigrants made decisions about their living arrangements. Fourteen Taiwanese older adu... |
20860320 | Beware of the dog. | An anomaly in the Dangerous Dogs Act means that nurses who visit people in their own homes have little redress if they are bitten. |
20860335 | Aging in America: quality of life among older Vietnamese women immigrants. | The purpose of this ethnographic research was to describe factors related to and elicit the meaning of "quality of life" in a group of older Vietnamese women immigrants. Thirty-three women who emigrated from Vietnam to the United States after 1978 participated in audiotaped interviews. Ethnographic content analysis was... |
20860325 | Learning how to undertake a systematic review: Part 2. | This article, the second in a two-part series, continues to describe the stages involved in conducting a systematic review. The article discusses how to select and appraise studies for inclusion in the review, and how to extract, synthesise and present the findings. A summary of the key points for writing the results a... |
20860336 | Overcoming cultural barriers to diabetes control: a qualitative study of southwestern New Mexico Hispanics. | This qualitative study examined the impact of cultural barriers on self-management of diabetes among Hispanic participants in LA VIDA (Lifestyle and Values Impact Diabetes Awareness), a diabetes intervention program in southwestern New Mexico. As part of the LA VIDA program evaluation, in depth interviews were conducte... |
20860347 | Solid-state (127)I NMR and GIPAW DFT study of metal iodides and their hydrates: structure, symmetry, and higher-order quadrupole-induced effects. | Central-transition (127)I solid-state nuclear magnetic resonance (SSNMR) spectra are presented for several anhydrous group 2 metal iodides (MgI(2), CaI(2), SrI(2), and BaI(2)), hydrates (BaI(2)·2H(2)O and SrI(2)·6H(2)O), and CdI(2) (4H polytype). Variable offset cumulative spectrum data acquisition coupled with echo pu... |
20860348 | Tuning the intramolecular charge transfer emission from deep blue to green in ambipolar systems based on dibenzothiophene S,S-dioxide by manipulation of conjugation and strength of the electron donor units. | The efficient synthesis and photophysical properties of a series of ambipolar donor-acceptor-donor systems is described where the acceptor is dibenzothiophene S,S-dioxide and the donor is fluorene, carbazole, or arylamine. The systems exhibit intramolecular charge transfer (ICT) states (of variable ICT character streng... |
20860349 | Re-engineering erythropoietin as an IgG fusion protein that penetrates the blood-brain barrier in the mouse. | Erythropoietin (EPO) is a potent neuroprotective agent that could be developed for the treatment of multiple brain disorders. However, EPO does not cross the blood-brain barrier (BBB). A brain-penetrating form of EPO, specific for the mouse, was engineered by fusion of the 166 amino acid EPO to the carboxyl terminus of... |
20860350 | Electronic structure and (1)H NMR chemical shifts in host-guest complexes of cucurbit[6]uril and sym-tetramethyl cucurbit[6]uril with imidazole derivatives. | Binding patterns and (1)H NMR chemical shifts in plexes of protonated N-(4-hydroxylphenyl)imidazole (g1), N-(4-aminophenyl)imidazole (g2), 2-phenylimidazole (g3) guests with cucurbit[6]uril (CB[6]), and sym-substituted tetramethyl cucurbit[6]uril (TMeCB[6]) in the gas phase as well as in water have been investigated us... |
20860345 | Cone beam CT--anatomic assessment and legal issues: the new standards of care. | Until the recent introduction of cone puted tomography scanners, standard 2-D imaging provided a moderate contribution to overall treatment planning when considering the diagnostic potential, costs of study and risks to the patient. Cone puted tomography-dedicated maxillofacial imaging scanners provide broader imaging ... |
20860351 | Selective binding of antiinfluenza drugs and their analogues to 'open' and 'closed' conformations of H5N1 neuraminidase. | It was suggested that the open conformation of the 150-loop of H5N1 avian influenza neuraminidase is intrinsically lower in energy than the closed conformation and that oseltamivir (tamiflu) favors binding to the closed conformation through a relatively slow conformational change [Russell, R. J. Nature 2006, 443, 45-49... |
20860352 | Analysis of measured and calculated Raman spectra of indole, 3-methylindole, and tryptophan on the basis of observed and predicted isotope shifts. | The aromatic amino acid tryptophan plays an important role in protein electron-transfer and in enzyme catalysis. Tryptophan is also used as a probe of its local protein environment and of dynamic changes in this environment. Raman spectroscopy of tryptophan has been an important tool to monitor tryptophan, its radicals... |
20860353 | A combined experimental and computational thermodynamic study of difluoronitrobenzene isomers. | This work reports the experimental putational thermochemical study performed on three difluorinated nitrobenzene isomers: 2,4-difluoronitrobenzene (2,4-DFNB), 2,5-difluoronitrobenzene (2,5-DFNB), and 3,4-difluoronitrobenzene (3,4-DFNB). The standard (p° = 0.1 MPa) molar enthalpies of formation in the liquid phase of po... |
20860354 | Miniaturized high-resolution time-of-flight mass spectrometer MULTUM-S II with an infinite flight path. | A new miniature multiturn time-of-flight (TOF) analyzer "MULTUM-S II" has been designed and constructed. This instrument consists of an electron ionization source, the multiturn TOF ion optics, a detector, vacuum system, and electronic circuits. The multiturn TOF analyzer consists of four electrostatic toroidal sectors... |
20860355 | Metallacarboranes: toward promising hydrogen storage metal organic frameworks. | Using first principles calculations, we show the high hydrogen storage capacity of metallacarboranes, where the transition metal (TM) atoms can bind up to 5 H(2)-molecules. The average binding energy of ∼0.3 eV/H favorably lies within the reversible adsorption range. Among the first row TM atoms, Sc and Ti are found to... |
20860356 | Photocatalytic formation of I-I bonds using DNA which enables detection of single nucleotide polymorphisms. | By decreasing the HOMO energy gap between the base-pairs to increase the charge conductivity of DNA, the positive charge photochemically generated in DNA can be made to migrate along the π-way of DNA over long distances to form a long-lived charge-separated state. By fine-tuning the kinetics of the charge-transfer reac... |
20860357 | The structure of formaldehyde-inhibited xanthine oxidase determined by 35 GHz 2H ENDOR spectroscopy. | The formaldehyde-inhibited Mo(V) state of xanthine oxidase (I) has been studied for four decades, yet it has not proven possible to distinguish unequivocally among the several structures proposed for this form. The uniquely large isotropic hyperfine coupling for (13)C from CH(2)O led to the intriguing suggestion of a d... |
20860358 | Stimuli-responsive smart gels realized via modular protein design. | Smart gels have a variety of applications, including tissue engineering and controlled drug delivery. Here we present a modular, bottom-up approach that permits the creation of protein-based smart gels with encoded morphology, functionality, and responsiveness to external stimuli. The properties of these gels are encod... |
20860359 | Nickel-catalyzed stereoselective glycosylation with C(2)-N-substituted benzylidene D-glucosamine and galactosamine trichloroacetimidates for the formation of 1,2-cis-2-amino glycosides. Applications to the synthesis of heparin disaccharides, GPI anchor pseudodisaccharides, and α-GalNAc. | The 1,2-cis-2-amino glycosides are ponents found within a variety of biologically important oligosaccharides and glycopeptides. Although there are remarkable advances in the synthesis of 1,2-cis-2-amino glycosides, disadvantages of the current state-of-the-art methods include limited substrate scope, low yields, long r... |
20860360 | Ratiometric and intensity-based zinc sensors built on rhodol and rhodamine platforms. | A xanthene-forming condensation reaction yields rhodol and rhodamine dyes carrying a zinc-binding ligand that includes the aniline-type nitrogen donor of the fluorophores. Upon zinc coordination in neutral aqueous solution, rhodol RF3 behaves as a ratiometric sensor, and rhodamine RA1 acts as a turn-off intensity-based... |
20860361 | A coordination cage with an adaptable cavity size. | A hexanuclear coordination cage can increase the size of its cavity from nearly zero to more than 500 Å(3), which allows the encapsulation of two coronene molecules. |
20860362 | Highly fluorescent platinum(II) organometallic complexes of perylene and perylene monoimide, with Pt σ-bonded directly to the perylene core. | 3-Bromoperylene (BrPer) or N-(2,5-di-tert-butylphenyl)-9-bromo-perylene-3,4-dicarboximide (BrPMI) react with [Pt(PEt(3))(4)] to yield trans-[PtR(PEt(3))(2)Br] (R = Per, 1a; R = PMI, 1b). Neutral and cationic plexes containing a Pt(PEt(3))X group have been prepared from 1a,b by substitution of the Br ligand by a variety... |
20860363 | Three-dimensional metal-organic frameworks based on tetrahedral and square-planar building blocks: hydrogen sorption and dye uptake studies. | Two three-dimensional metal-organic frameworks (MOFs) with tetraphenylmethane-derived tetracarboxylate linkers and copper paddle-wheel secondary building units were synthesized and characterized by single-crystal X-ray crystallographic studies. The two MOFs show a similar 4,4-connectivity but very different homocrossin... |
20860364 | (Ag2TeS3)2·A2S6 (A = Rb, Cs): layers of silver thiotellurite intergrown with alkali-metal polysulfides. | The pounds RbAg(2)TeS(6) and CsAg(2)TeS(6) crystallize in the noncentrosymmetric space group P6(3)cm, with a = 19.15 Å, c = 14.64 Å, and V = 4648 Å(3) and a = 19.41 Å, c = 14.84 Å, and V = 4839 Å(3), respectively. The structures posed of neutral [Ag(2)TeS(3)] layers alternating with charge-balanced salt layers containi... |
20860365 | Synthesis of quaternary carbon stereogenic centers through enantioselective Cu-catalyzed allylic substitutions with vinylaluminum reagents. | Catalytic enantioselective allylic substitution (EAS) reactions, which involve the use of alkyl- or aryl-substituted vinylaluminum reagents and afford 1,4-dienes containing a quaternary carbon stereogenic center at their C-3 site, are disclosed. The C-C bond-forming transformations are promoted by 0.5-2.5 mol % of sulf... |
20860366 | New anthracenedione derivatives with improved biological activity by virtue of stable drug-DNA adduct formation. | Mitoxantrone is an anticancer agent that acts as a topoisomerase II poison, however, it can also be activated by formaldehyde to form DNA adducts. Pixantrone, a 2-aza-anthracenedione with terminal primary amino groups in its side chains, forms formaldehyde-mediated adducts with DNA more efficiently than mitoxantrone. M... |
20860367 | Dynamics of biocatalytic microengines mediated by variable friction control. | We describe the motion of self-propelled hybrid microengines containing catalase enzyme covalently bound to the cavity of rolled-up microtubes. The high efficiency of these hybrid microengines allows them to move at a very low concentration of peroxide fuel. The dynamics of the catalytic engines is mediated by the gene... |
20860368 | Magnetic properties of segregated layers containing M(II)3(μ3-OH)2 (M = Co or Ni) diamond chains bridged by cis,cis,cis-1,2,4,5-cyclohexanetetracarboxylate. | We report the hydrothermal synthesis, X-ray crystal structures, and thermal, optical, and magnetic properties of two isostructural layered coordination polymers, [M(II)(5)(OH)(2)(chtc)(2)(H(2)O)(10)]·2H(2)O where M = Co (1Co) or Ni (2Ni) and chtc = cis,cis,cis-1,2,4,5-cyclohexanetetracarboxylate. The structures consist... |
20860369 | The use of polarizable [AuX2(CN)2]- (X = Br, I) building blocks toward the formation of birefringent coordination polymers. | The [(n)Bu(4)N][AuX(2)(CN)(2)] (X = Br, I) salts were synthesized and structurally characterized. Both feature square-planar [AuX(2)(CN)(2)](-) anions, with trans cyano and halo ligands, which aggregate via halogen-halogen interactions. The aggregation of [AuX(2)(CN)(2)](-) units results in the parallel alignment of al... |
20860371 | Effects of organic and conventional growth systems on the content of flavonoids in onions and phenolic acids in carrots and potatoes. | The demand for organic food products is steadily increasing partly due to the expected health benefits of organic food consumption. Polyphenols, such as flavonoids and phenolic acids, are a group of secondary plant metabolites with presumably beneficial health effects, and contents in plants are affected by, for exampl... |
20860370 | Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. | The mTOR protein is a master regulator of cell growth and proliferation, and inhibitors of its kinase activity have the potential to e new class of anticancer drugs. Starting from quinoline 1, which was identified in a biochemical mTOR assay, we developed a tricyclic benzonaphthyridinone inhibitor 37 (Torin1), which in... |
20860372 | Facile access to tetravalent cerium compounds: one-electron oxidation using iodine(III) reagents. | Readily accessible and easy-to-use phenyliodine(III) dichloride, PhICl(2), has been established as an innovative and superior reagent for the one-electron oxidation of prising amide, amidinate, and cyclopentadienyl derivatives. Its use allowed the successful synthesis and structural characterization of the first member... |
20860373 | High resolution measurement of methyl 13C(m)-13C and 1H(m)-13C(m) residual dipolar couplings in large proteins. | NMR methodology is developed for high-resolution, accurate measurements of methyl (1)H(m)-(13)C(m) ((1)D(CH)) and (13)C(m)-(13)C ((1)D(CC)) residual dipolar couplings (RDCs) in ILV-methyl-protonated high-molecular-weight proteins. Both types of RDCs are measured in a three-dimensional (3D) mode that allows dispersion o... |
20860374 | Synthesis of graphene aerogel with high electrical conductivity. | We report the synthesis of ultra-low-density three-dimensional macroassemblies of graphene sheets that exhibit high electrical conductivities and large internal surface areas. These materials are prepared as monolithic solids from suspensions of single-layer graphene oxide in which organic sol-gel chemistry is used to ... |
20860376 | Long-term simulation of human exposure to atmospheric perfluorooctanoic acid (PFOA) and perfluorooctanoate (PFO) in the Osaka urban area, Japan. | A publicly available atmospheric transport model, the Weather Research and Forecasting Chemistry Model ( ), was used to simulate atmospheric perfluorooctanoic acid (PFOA) and perfluorooctanoate (PFO) emitted from a point source in the Osaka urban area (also known as Keihanshin), Japan. The time period of the simulatio... |
20860377 | Amino acids at water-vapor interfaces: surface activity and orientational ordering. | The surface activity and orientational ordering of amino acids at water-vapor interfaces were studied with molecular dynamics simulations bination with thermodynamic integration and umbrella sampling. Asparagine, representing amino acids with polar side chains, displays no surface activity. Tryptophan, in contrast, wit... |
20860375 | Photocleavable peptide-conjugated magnetic beads for protein kinase assays by MALDI-TOF MS. | Peptides were immobilized onto superparamagnetic beads via photocleavable linkers. This enabled simple, rapid, and label-free protein kinase assays via MALDI-TOF MS detection of substrate peptide phosphorylation. Abltide, a model substrate for the Abl protein tyrosine kinase model, was coupled onto amine-terminated bea... |
20860378 | Proteome analysis of multiple compartments in a mouse model of chemical-induced asthma. | Occupational asthma is the principal cause of work-related respiratory disease in the industrial world. Toluene-2,4-diisocyanate (TDI) is one of the mon respiratory sensitizers leading to occupational asthma. Using a mouse model of chemical-induced asthma, we explored proteome changes in partments of mice sensitized an... |
20860379 | Atomistic simulation of water percolation and proton hopping in Nafion fuel cell membrane. | We have performed a detailed analysis of water clustering and percolation in hydrated Nafion configurations generated by classical molecular dynamics simulations. Our results show that at low hydration levels H(2)O molecules are isolated and a continuous hydrogen-bonded network forms as the hydration level is increased... |
20860380 | Dynamic hybrid life cycle assessment of energy and carbon of multicrystalline silicon photovoltaic systems. | This paper advances the life cycle assessment (LCA) of photovoltaic systems by expanding the boundary of the included processes using hybrid LCA and accounting for the technology-driven dynamics of embodied energy and carbon emissions. Hybrid LCA is an extended method bines bottom-up process-sum and top-down economic i... |
20860381 | Novel pyridylmethylamines as highly selective 5-HT(1A) superagonists. | To further improve the maximal serotonergic efficacy and better understand the configurational requirements for 5-HT(1A) binding and activation, we generated and biologically investigated structural variants of the lead structure befiradol. For a bioisosteric replacement of the 3-chloro-4-fluoro moiety, a focused libra... |
20860383 | The thermosalient phenomenon. "Jumping crystals" and crystal chemistry of the anticholinergic agent oxitropium bromide. | The anticholinergic agent oxitropium bromide possesses rich crystal chemistry, most remarkably exhibiting a strong thermosalient effect ("jumping crystal" effect), a mechanical property with potential applications in organic-based actuators. The thermosalient effect, manifested in forceful jumps of up to several centim... |
20860382 | Crystals in which some metal atoms are more equal than others: inequalities from crystal packing and their spectroscopic/magnetic consequences. | Crystal structures of the pounds CrCrFe(dpa)(4)Cl(2) (1), CrCrMn(dpa)(4)Cl(2) (2), and MoMoMn(dpa)(4)Cl(2) (3) (dpa = 2,2'-dipyridylamide) show disorder in the metal atom positions such that the linear M(A)[quadruple bond]M(A)···M(B) array for a given molecule in the crystal is oriented in one of two opposing direction... |
20860384 | Boronic acid porphyrin receptor for ginsenoside sensing. | Ginsenoside detection was pursued through the design of a porphyrin receptor containing two boronic acid units. This receptor was found to undergo different degrees of fluorescence quenching with five ginsenoside guests and an acylated derivative. The trends in the 1:1 binding constants, as well as ESI-HRMS analysis, s... |
20860385 | High-pressure dielectric investigations of nanocolloidal Aerosil-nematic liquid crystal composites. | We report the effect of applied pressure on the dielectric properties posites of a nematic liquid crystal with hydrophilic Aerosil particles. The study, which is the first of its kind on the nanocolloidal Aerosil systems, also has the novelty that a weakly polar nematogen is used as the host material. In conjunction wi... |
20860386 | Length scales and dynamics in the reorientational relaxation of tracers in molecular and polymeric glass formers via electron spin resonance spectroscopy. | It is widely accepted that a temperature region exists above the glass transition temperature, playing a fundamental role in the physics of polymers and glass formers. In this region, several dynamic crossovers have been experimentally and numerically revealed in the past years and the onset of glassy behavior is gener... |
20860387 | Toward a prediction of the redox properties of electroactive SAMs: a free energy calculation by molecular simulation. | We report free energy calculations of FcC(6)S-/C(4)S-Au and FcC(6)S-/C(12)S-Au binary self-assembled monolayers (SAMs) formed by one ferrocenylhexanethiolate chain and alkylthiolate chains. We demonstrate that the free energy perturbation methods are able to reproduce the positive shift of the redox potential when the ... |
20860388 | Simulations of a protein crystal with a high resolution X-ray structure: evaluation of force fields and water models. | We use classical molecular dynamics and binations of force fields and water models to simulate a protein crystal observed by room-temperature X-ray diffraction. The high resolution of the diffraction data (0.96 Å) and the simplicity of the crystallization solution (nearly pure water) make it possible to attribute any i... |
20860389 | Cationic alkylaluminum-complexed zirconocene hydrides as participants in olefin polymerization catalysis. | The plexed zirconocene trihydride cation [(SBI)Zr(μ-H)(3)(Al(i)Bu(2))(2)](+), which is obtained by reaction of (SBI)ZrCl(2) with [Ph(3)C][B(C(6)F(5))(4)] and excess HAl(i)Bu(2) in toluene solution, catalyzes the formation of isotactic polypropene when exposed to propene at -30 °C. This cation remains the sole observabl... |
20860390 | Characterization of plant exudates by principal-component and cluster analyses with nuclear magnetic resonance variables. | ponent and cluster analyses have been applied to nuclear magnetic resonance data for exudates derived from both conifers and angiosperms in order to classify these materials on the basis of molecular structure. The method succeeds in distinguishing resins produced by the conifer families Araucariaceae, Cupressaceae, an... |
20860391 | Isolation and characterization of diastereomers of discorhabdins H and K and assignment of absolute configuration to discorhabdins D, N, Q, S, T, and U. | Investigations of four different sponge populations of Latrunculia species collected in New Zealand waters has led to the characterization of a new diastereomer of discorhabdin H, named discorhabdin H2, confirmation of the structure of discorhabdin K ((+)-7), and presentation of a new diastereomer, discorhabdin K2 ((-)... |
20860392 | Chemical interactions of surface-active agents with growing resorcinol-formaldehyde gels. | The influence of cationic, anionic, and nonionic surfactants (S) on the characteristics of carbon xerogels was analyzed. The polymerization of resorcinol (R) and formaldehyde (F) was developed in an aqueous solution of S without any additional catalyst. The gels obtained were dried in air to obtain organic xerogels and... |
20860393 | Palladium-catalyzed amination of unprotected halo-7-azaindoles. | Simple and efficient procedures for the Pd-catalyzed cross-coupling of primary and secondary amines with halo-7-azaindoles(pyrrolo[2,3-b]pyridine) are presented. Previously, no general method was available to ensure the highly selective reaction of the heteroaryl halide in the presence of the unprotected azaindole N-H.... |
20860394 | A five-step synthesis of (S)-macrostomine from (S)-nicotine. | A concise synthesis of (S)-macrostomine has been plished in five steps from natural nicotine in 19% overall yield via a pyridyne Diels-Alder cycloaddition reaction as the key step. A Kumada cross-coupling reaction on a 1-chloroisoquinoline intermediate provided the natural product. |
20860395 | Cleavage and reorganization of Zr-C/Si-C bonds leading to Zr/Si-N organometallic and heterocyclic compounds. | The t-BuCN-stabilized plexes 2 are generated in situ in high yields from the Si-tethered diynes, Cp(2)Zr(II) species, and 2 equiv of t-BuCN via a coordination-induced Zr-C/Si-C bond cleavage and reorganization. Complexes 2 have been demonstrated to be synthetically very useful. A variety of novel Zr/Si pounds and Si/N ... |
20860396 | Supramolecular chirality in organogels: a detailed spectroscopic, morphological, and rheological investigation of gels (and xerogels) derived from alkyl pyrenyl urethanes. | This Article addresses the formation of chiral supramolecular structures in the organogels derived from chiral organogelator 1R (or 2R), and its mixtures with its enantiomer (1S) and achiral analogue 3 by extensive circular dichroism (CD) spectroscopic measurements. Morphological analysis by atomic force microscopy (AF... |
20860398 | How micropatterns and air pressure affect splashing on surfaces. | We experimentally investigate the splashing mechanism of a millimeter-sized ethanol drop impinging on a structured solid posed of micropillars, through side-view and top-view high-speed imaging. By increasing the impact velocity, we can tune the impact e from a gentle deposition to a violent splash, at which tiny dropl... |
20860397 | Cellular response of polyvalent oligonucleotide-gold nanoparticle conjugates. | Nanoparticles are finding utility in myriad biotechnological applications, including gene regulation, intracellular imaging, and medical diagnostics. Thus, evaluating the patibility of these nanomaterials is imperative. Here we use genome-wide expression profiling to study the biological response of HeLa cells to gold ... |
20860399 | Computer simulation of argon adsorption on graphite surface from subcritical to supercritical conditions: the behavior of differential and integral molar enthalpies of adsorption. | We investigate in detail puter simulation of argon adsorption on a graphite surface over a very wide range of temperature, from below the triple point to well above the critical point. Adsorption over such a wide temperature range has not been reported previously in the form of adsorption isotherms and enthalpy change ... |
20860400 | Reactive dynamics in micelles: auramine O in solution and adsorbed on regular micelles. | The role of confinement in the suppression of the excited-state reaction of the dye molecule auramine O in nanoscale water droplets is investigated by contrasting the behavior of the dye in solution and on regular and reverse micelles. Auramine O photophysics are studied in bulk water, at the interface between regular ... |
20860401 | Metallic nanoshells with semiconductor cores: optical characteristics modified by core medium properties. | It is well-known that the geometry of a nanoshell controls the resonance frequencies of its plasmon modes; however, the properties of the core material also strongly influence its optical properties. Here we report the synthesis of Au nanoshells with semiconductor cores of cuprous oxide and examine their optical charac... |
20860402 | Self-assembled enzyme capsules in ionic liquid [BMIM][BF4] as templating nanoreactors for hollow silica nanocontainers. | Most of the self-assembly studies have hitherto explored the aqueous media as fluid phase for self-assembly of amphiphilic biomacromolecules, wherein architectural modification of biomolecules is generally a prerequisite for self-assembly of modified biomolecules. We demonstrate for the first time that ionic liquids ca... |
20860403 | Efficient Pd-catalyzed amination reactions for heterocycle functionalization. | The Pd-catalyzed amination of unprotected benzo-fused heterocycles is reported, which allows for greater flexibility and efficiency in the modification of this important class of molecules. The generality of these simple and efficient procedures is demonstrated through the synthesis of a wide variety of structural type... |
20860404 | Stereocontrol of 5,5-spiroketals in the synthesis of cephalosporolide H epimers. | A blueprint for controlling the stereochemistry of oxygenated 5,5-spiroketals using chelation effects is provided. Chelation specifically of zinc salts (other protic and Lewis acids were less effective) between the spiroketal oxygen and an appropriately positioned alcohol group overrides normal biases in the preparatio... |
20860405 | Calculated nuclear magnetic resonance parameters for multiproton-exchange and nonbonded-hydrogen rotation processes in cyclic water clusters. | In this work we report, for the first time, calculations of nuclear magnetic resonance parameters for the processes of multiproton-exchange and nonbonded-proton rotations in small, cyclic water clusters. The simultaneous proton exchange induces a large decrease in the oxygen shielding constants in both clusters, with a... |
20860406 | Complex surface concentration gradients by stenciled "electro click chemistry". | Complex one- or two-dimensional concentration gradients of alkynated molecules are produced on azidized conducting polymer substrates by stenciled "electro click chemistry". The latter describes the local electrochemical generation of catalytically active Cu(I) required plete a "click reaction" between alkynes and azid... |
20860407 | Dioxin-like activity in Japanese indoor dusts evaluated by means of in vitro bioassay and instrumental analysis: brominated dibenzofurans are an important contributor. | In our previous study, we demonstrated that dioxin-like activity in sulfuric-acid-treated extracts of Japanese indoor dust was higher than the activity in contaminated sediments. In the current study, we used high-performance liquid chromatography (HPLC) fractionation bination with the dioxin-responsive chemical-activa... |
20860408 | Myo1e binds anionic phospholipids with high affinity. | Myo1e is a single-headed motor protein that has been shown to play roles in clathrin-mediated endocytosis in HeLa cells and podocyte function in the kidney. The myo1e C-terminal tail domain includes a basic region that is required for localization to clathrin-coated vesicles and contains a putative pleckstrin-homology ... |
20860409 | Molecular studies of model surfaces of metals from single crystals to nanoparticles under catalytic reaction conditions. Evolution from prenatal and postmortem studies of catalysts. | Molecular level studies of metal crystal and nanoparticle surfaces under catalytic reaction conditions at ambient pressures during turnover were made possible by the use of instruments developed at the University of California at Berkeley. Sum frequency generation vibrational spectroscopy (SFGVS), owing to its surface ... |
20860411 | Hess-Schaad group additivity type model predicts superaromaticity. | The classical Hess-Schaad reference state and group additivity (GA) model has been adapted to evaluate the resonance energies of several polycyclic aromatic hydrocarbons (PAHs). It was found that benzene is the least stable species in this series, and hence, claims that the concept of superaromaticity is dead are overe... |
20860410 | Long-range interaction networks in the function and fidelity of poliovirus RNA-dependent RNA polymerase studied by nuclear magnetic resonance. | The fidelity of the poliovirus RNA-dependent RNA polymerase (3D(pol)) plays a direct role in the genomic evolution and pathogenesis of the virus. A single site mutation (Gly64Ser) that is remote from the catalytic center results in a higher fidelity polymerase. NMR studies with [methyl-(13)C]methionine-labeled protein ... |
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