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20860412 | Expanded π-electron systems, tri(phenanthro)hexaazatriphenylenes and tri(phenanthrolino)hexaazatriphenylenes, that are self-assembled to form one-dimensional aggregates. | This paper reports the self-assembling and electrochemical nature of hexaazatriphenylene-based electron-deficient heteroaromatics with an expanded π-electron system. The tri(phenanthro)hexaazatriphenylenes (TPHAT-Cs) and tri(phenanthrolino)hexaazatriphenylenes (TPHAT-Ns) were prepared by condensation reactions of the c... |
20860413 | A 50-week extension study on the safety and efficacy of colesevelam in adults with primary hypercholesterolemia. | Colesevelam is a bile acid sequestrant that differs structurally from traditional bile acid sequestrants, allowing it to bind bile acids with greater affinity. Studies have shown that colesevelam significantly reduces low-density lipoprotein cholesterol (LDL-C) levels and, in some cases, significantly increases high-de... |
20860414 | The role of Angiotensin receptor blocker and calcium channel blocker combination therapy in treating hypertension: focus on recent studies. | Hypertension remains a significant health problem, affecting approximately 30% of the US population. Of these, only 36.8% have BP controlled to mended levels of <140/90 mmHg for plicated hypertension and <130/80 mmHg for patients with diabetes mellitus or renal disease. For those with uncontrolled hypertension, the ris... |
20860415 | Cardiovascular risk-benefit profile of sibutramine. | Sibutramine is bined norepinephrine and serotonin reuptake inhibitor used as an antiobesity agent to reduce appetite and promote weight loss bination with diet and exercise. At a daily dose of 10-20 mg, it was initially considered to have a good safety profile, as it does not induce primary pulmonary hypertension or ad... |
20860416 | Candesartan cilexetil: in children and adolescents aged 1 to <17 years with hypertension. | Candesartan cilexetil is the orally administered prodrug of candesartan, an angiotensin II subtype 1 receptor antagonist. The pharmacokinetics (area under the plasma concentration-time curve and maximum plasma concentration) of candesartan do not appear to be affected by age, sex, or weight, with a similar exposure obs... |
20860417 | Riferminogene pecaplasmide. | Sanofi-aventis is developing riferminogene pecaplasmide, a fibroblast growth factor 1 (FGF-1; NV1FGF) gene therapy for the treatment of peripheral arterial disorders (PAD) such as critical limb ischemia. Following intramuscular injection into an area of restricted blood flow, riferminogene pecaplasmide is taken up by m... |
20860418 | Outcomes of children and adolescents with well-differentiated thyroid carcinoma and pulmonary metastases following ¹³¹I treatment: a systematic review. | The optimal dose and efficacy of ¹³¹I treatment of children and adolescents with well-differentiated thyroid carcinoma (WDTC) and pulmonary metastases are not well established. A therapeutic challenge is to achieve the maximum benefit of ¹³¹I to decrease disease-related morbidity and obtain disease-free survival while ... |
20860419 | The relationship of preconception thyrotropin levels to requirements for increasing the levothyroxine dose during pregnancy in women with primary hypothyroidism. | Most women with hypothyroidism require an increase in their dose of levothyroxine (LT4) after conception. To minimize fetal and plications of maternal hypothyroidism, it is thought that women should be rapidly restored to the euthyroid state. The objectives of this study was to determine the percentage of hypothyroid w... |
20860420 | Dietary iodine restriction in preparation for radioactive iodine treatment or scanning in well-differentiated thyroid cancer: a systematic review. | Dietary iodine is often restricted before radioactive iodine (RAI) scanning or treatment of well-differentiated thyroid cancer. Our objective was to examine the impact of a low-iodine diet (LID) before RAI treatment or scanning on the following es: (i) the efficacy of thyroid remnant ablation (or residual disease elimi... |
20860422 | Real-time elastography for the differentiation of benign and malignant thyroid nodules: a meta-analysis. | Work-up of thyroid nodules remains challenging. Fine-needle aspiration (FNA) has been shown to be the most cost-effective way to select patients for surgery with sensitivities of 54%–90% and specificities of 60%–96% for the detection of malignant lesions. Ultrasound-based real-time elastography (RTE) enables the determ... |
20860423 | Impact of pregnancy on outcome and prognosis of survivors of papillary thyroid cancer. | Papillary thyroid cancer monly affects women of child-bearing age. During normal pregnancy, several factors may have a stimulatory effect on normal and nodular thyroid growth. The aim of the study was to determine whether pregnancy in thyroid-cancer survivors poses a risk of progression or recurrence of the disease. |
20860424 | Thyroid cancer resistance to vitamin D receptor activation is associated with 24-hydroxylase levels but not the ff FokI polymorphism. | The vitamin D receptor (VDR) has been studied as a novel target for cancer therapy in many tissue types as VDR ligands decrease cell proliferation in vitro and decrease tumor growth in vivo in sensitive cells. The objective of this study was to analyze the response to VDR agonist therapy in a panel of validated thyroid... |
20860425 | Variable suppression of serum thyroxine in female mice of different inbred strains by triiodothyronine administered in drinking water. | binant-inbred mouse strains differ in their susceptibility to Graves'-like hyperthyroidism induced by immunization with adenovirus expressing the human thyrotropin (TSH) receptor. Because one ponent contributing to this susceptibility is altered thyroid sensitivity to TSH receptor agonist stimulation, we wished to quan... |
20860426 | Short-term exposure of umbilical cord blood CD34+ cells to granulocyte-macrophage colony-stimulating factor early in culture improves ex vivo expansion of neutrophils. | Despite the availability of modern antibiotics/antimycotics and cytokine support, neutropenic infection accounts for the majority of chemotherapy-associated deaths. While transfusion support with donor neutrophils is possible, cost plicated logistics make such an option unrealistic on a routine basis. A manufactured ne... |
20860427 | Isolation and characterization of equine amniotic fluid-derived multipotent stem cells. | Amniotic fluid (AF) is a well-known source of stem cells. However, there have been no reports regarding equine AF stem cells. We have isolated equine AF-derived multipotent stem cells (MSC) (eAF-MSC) and show that these cells exhibit self-renewal ability and multilineage differentiation. |
20860428 | Dental erosive wear among Norwegian wine tasters. | To assess the prevalence and severity of dental erosive wear among a group of professional wine tasters. |
20860429 | Sense of coherence and oral health status in an adult Swedish population. | To investigate sense of coherence in relation to oral health status in an adult Swedish population in order to better understand the determinants of positive oral health-promoting behavior and differences in oral health. |
20860430 | Molecular, morphologic, and outcome analysis of thyroid carcinomas according to degree of extrathyroid extension. | The impact of varying degrees of extrathyroid extension (ETE), especially microscopic ETE (METE), on survival in thyroid carcinomas (TC) has not been well established. Our objective was to analyze ETE at the molecular and histologic levels and assess the effect of its extent on e. |
20860431 | Quality improvement in palliative care services and networks: preliminary results of a benchmarking process in Catalonia, Spain. | A wide range of palliative care services has been implemented in Catalonia over the past 20 years. Quantitative and qualitative differences in the organization of palliative care services between districts and settings can result in wide variability in the quality of these services, and their accessibility. |
20860432 | Socioeconomic disparities in trajectories of adiposity across childhood. | Socioeconomic inequalities in obesity are consistently observed in e countries. The development of such inequalities across childhood; however, has not been studied using longitudinal data. |
20860433 | What factors are important in increasing junior doctors' willingness to provide palliative care in Taiwan? An educational intervention study. | To explore the factors that influence the willingness of junior doctors to provide palliative care in future clinical practice and to evaluate the effect of palliative care education in ameliorating these factors. |
20860434 | Simultaneous methylation profiling of tumor suppressor genes in head and neck cancer. | Head and neck cancer (HNC) is mon cancer, and its prognosis has not changed during the last decades. Detection of the disease at an early stage is crucial for successful treatment, as early diagnosis can significantly increase the survival rate. Methylation of tumor suppressor genes is an early event in cancer responsi... |
20860436 | Antianxiety activity of Gelsemium sempervirens. | The clinical applications of well-known benzodiazepines as anxiolytic agents are limited because of their side effects. Therefore, the development of new pharmacological agents, from medicinal plants, is well justified. |
20860437 | The antinociceptive and anti-inflammatory effects of Salvia officinalis leaf aqueous and butanol extracts. | The leaf of sage Salvia officinalis L. (Lamiaceae) is reputed in the folk medicine of Arabia, and Jordan in particular, to relieve pain associated with gastrointestinal disturbance. |
20860438 | Protective effect of Amaranthus spinosus against D-galactosamine/lipopolysaccharide-induced hepatic failure. | The current study is an effort to identify the hepatoprotective activity of the 50% ethanol extract of the whole plant of Amaranthus spinosus Linn. (Amaranthaceae) against d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced liver injury in rats. d-GalN/LPS (300 mg/kg body weight/30 µg/kg body weight)-induced hepati... |
20860440 | Hip resurfacing arthroplasty. | Hip resurfacing arthroplasty is claimed to allow higher activity levels and to give better quality of life than total hip arthroplasty. In this literature review, we assessed the therapeutic value of hip resurfacing arthroplasty as measured by functional e. |
20860441 | Neuropeptide Y innervation during fracture healing and remodeling. A study of angulated tibial fractures in the rat. | Autonomic neuropeptide Y (NPY) is involved in local bone remodeling via the central nervous system. However, the role of peripheral neuronal NPY in fracture healing is not known. We investigated the relationship between bone healing and side-specific occurrence of NPY in angular and straight fractures. |
20860439 | Immunosuppressive activity on the murine immune responses of glycyrol from Glycyrrhiza uralensis via inhibition of calcineurin activity. | Calcineurin (CN), a unique protein phosphatase, plays an important role in immune regulation. Our laboratory has established an effective molecular drug-screening model based on CN activity. |
20860442 | More intramedullary nails and arthroplasties for treatment of hip fractures in Sweden. | The surgical methods for treatment of femoral neck fractures and trochanteric hip fractures vary. We describe the changes in Sweden over the period 1998–2007 and the regional differences in treatment. Patients and methods Data on 144,607 patients were drawn from the National Patient Register. |
20860443 | The final follow-up plain radiograph is sufficient for clinical evaluation of polyethylene wear in total hip arthroplasty. A study of validity and reliability. | Radiostereometric analysis (RSA) is a highly accurate tool for assessment of polyethylene (PE) wear in total hip arthroplasty (THA); however, PE wear measurements in clinical studies are often limited to plain radiographs. We evaluated the agreement between PE wear measured with PolyWare software, which uses plain radi... |
20860444 | An important Norwegian contribution to the study of the bursae of the upper and lower extremities. | We present a critical analysis of the monograph of A.S.D. Synnestvedt (1869) “En anatomisk beskrivelse af de paa over- og underestremiteterne forekommende Bursae mucosae”. The analysis pleted using anatomical information from the historically oldest publications dealing with the bursae of the extremities: Albinus (1734... |
20860445 | Measurement of femoral head penetration in polyethylene using a 3-dimensional CT-scan technique. | Current techniques for measuring in vivo polyethylene wear suffer from a range of problems, resulting in an unacceptable lack of repeatability and/or insufficient accuracy when they are used to measure the low wear rates associated with new, highly crosslinked polyethylene. We describe an improved CT method for measure... |
20860446 | Lower limb amputations in Trondheim, Norway. | In the city of Trondheim, Norway, diabetic lower-limb amputations accounted for one-third of all lower-limb amputations (LLAs). In an attempt to reduce this rate, a diabetic foot team was established in 1996. We present the incidence of LLA in Trondheim as measured 10 years later. |
20860447 | A randomized, controlled trial comparing local infiltration analgesia with epidural infusion for total knee arthroplasty. | There have been few studies describing wound infiltration with additional intraarticular administration of multimodal analgesia for total knee arthroplasty (TKA). In this study, we assessed the efficacy of wound bined with intraarticular regional analgesia with epidural infusion on analgesic requirements and postoperat... |
20860448 | 6-year follow-up of 84 patients with cartilage defects in the knee. Knee scores improved but recovery was incomplete. | The natural history of focal cartilage injury is largely unknown. In this study we investigated 6-year es in patients with arthroscopically verified, focal, full-thickness cartilage injuries of the knee. |
20860451 | A new method for liposome preparation using a membrane contactor. | In this article, we present a novel, scalable liposomal preparation technique suitable for the entrapment of pharmaceutical agents into liposomes. This new method is based on the ethanol-injection technique and uses a membrane contactor module, specifically designed for colloidal system preparation. In order to investi... |
20860450 | Effects of metal-on-metal wear on the host immune system and infection in hip arthroplasty. | Joint replacement with metal-on-metal (MOM) bearings have gained popularity in the last decades in young and active patients. However, the possible effects of MOM wear debris and its corrosion products are still the subject of debate. Alongside the potential disadvantages such as toxicity, the influences of metal parti... |
20860452 | Reduced dislocation rate after hip arthroplasty for femoral neck fractures when changing from posterolateral to anterolateral approach. | Recent studies have shown pared to the posterolateral approach, the anterolateral approach reduces the risk of dislocation after hip arthroplasty in patients with femoral neck fractures. We have therefore started to use the anterolateral approach on these patients and we now report the consequences of this change for t... |
20860454 | Assessment of distraction callus in rabbits by monitoring of the electrical impedance of bone. | Evaluation of distraction callus is important for determination of the optimal time for removal of external fixation. We attempted to determine whether there might be a relationship between the electrical impedance of bone and callus maturation, with a view to using impedance as a way of knowing when to remove a fixato... |
20860453 | Risk factors for revision due to infection after primary total hip arthroplasty. A population-based study of 80,756 primary procedures in the Danish Hip Arthroplasty Registry. | There has been a limited amount of research on risk factors for revision due to infection following total hip arthroplasty (THA), probably due to low absolute numbers of revisions. We therefore studied patient- and surgery-related risk factors for revision due to infection after primary THA in a population-based settin... |
20860457 | Pharmacogenomic strategies against microbial resistance: from bright to bleak to innovative. | The last decade saw an alarming increase in antibiotic resistance in infections, with more than 13 million deaths per year from infections. Counter strategies include hygiene, antibiotic restriction and new antibiotics such as quinupristin, linezolid, tigecycline, daptomycin and dalbavancin. Presently, pharmacogenomics... |
20860463 | Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients. | Efavirenz (EFV) is characterized by interindividual pharmacokinetic variability causing inconsistent clinical responses. Previous studies have identified some possible genetic determinants of the variability in plasma concentrations. However, their impact on EFV intracellular pharmacokinetics remains mostly unexplored. |
20860464 | Effects of lipid-lowering drugs on reverse cholesterol transport gene expressions in peripheral blood mononuclear and HepG2 cells. | The ATP-binding cassette transporters, ABCA1 and ABCG1, are LXR-target genes that play an important role in reverse cholesterol transport. We examined the effects of inhibitors of the cholesterol absorption (ezetimibe) and synthesis (statins) on expression of these transporters in HepG2 cells and peripheral blood monon... |
20860465 | Host genetic variants in the IGF binding protein-3 impact on survival of patients with advanced gastric cancer treated with palliative chemotherapy. | IGF binding protein-3 (IGFBP-3) displays growth inhibitory/proapoptotic action and counteracts the IGF-1 tumor-promoting effects by downregulating its bioavailability. We investigated whether IGFBP-3 SNPs determining high IGFBP-3 circulating levels are associated with improved survival of patients with advanced gastric... |
20860462 | β-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein β-3 subunit variant. | Impaired heart rate (HR) response to exercise is associated with increased cardiovascular morbidity and mortality. We analyzed mon variants (rs5443/C825T and rs5442/G814A) in the G-protein β3 subunit (GNB3) gene modulate interindividual variation in β-blocker responses with respect to HR. |
20860466 | VKORC1 polymorphisms in Brazilians: comparison with the Portuguese and Portuguese-speaking Africans and pharmacogenetic implications. | The heterogeneity of the Brazilian population renders the extrapolation of pharmacogenomic data derived from well-defined ethnic groups inappropriate. We investigated the influence of self-reported 'race/color', geographical origin and genetic ancestry on the distribution of four VKORC1 SNPs and haplotypes in Brazilian... |
20860467 | Pharmacogenomics and active surveillance for serious adverse drug reactions in children. | Juxtaposing clinical pharmacology with human genetics, pharmacogenomics utilizes a patient's genetic information to identify genetic variants that have the potential to provide clinically relevant predictions of toxicity and efficacy. The goal is to develop personalized and genetic-based predictions of an individual's ... |
20860468 | Pharmacogenetics of osteoporosis-related bone fractures: moving towards the harmonization and validation of polymorphism diagnostic tools. | Osteoporosis is one of the mon skeletal chronic conditions in developed countries, hip fracture being one of its major healthcare es. There is considerable variation in the implementation of current pharmacological treatment and prevention, despite consistent mendations and guidelines. Many studies have reported confli... |
20860469 | Pharmacogenomic implications of variants of monoaminergic-related genes in geriatric psychiatry. | Response to psychiatric medications in later life is highly heterogeneous plex. Monoaminergic-related polymorphisms may influence medication response and susceptibility to side effects in elderly individuals. Individuals with the lower function short (S) allele of the serotonin transporter gene (SLC6A4) insertion/delet... |
20860470 | Pharmacogenomics instruction in US and Canadian medical schools: implications for personalized medicine. | To determine the extent of pharmacogenomics instruction at US and Canadian medical schools, characterize perceptions of curricular coverage, identify curricular resources pare responses with similar studies conducted in US pharmacy schools and British medical schools. |
20860477 | Managing invasive fungal infection in hematopoietic stem-cell transplantation. | Reduced intensity conditioning regimens and a wider range of donor sources, including cord blood, mean that more patients can be offered potentially curative allogeneic hematopoietic stem cell transplantation than ever before. Although these modalities aim to reduce procedure-related morbidity and mortality, their pote... |
20860474 | Anti-proliferative effect of levamisole on human myeloma cell lines in vitro. | Levamisole has been employed as an immunomodulatory agent in conjunction with 5-fluorouracil in the treatment of colon cancer relapse. At high doses, levamisole has been shown to have both anti-cancer and immunosuppressive activities. In vitro, levamisole has been shown to potentiate the anti-proliferative effect of 5-... |
20860479 | Advances in imaging the innate and adaptive immune response to Toxoplasma gondii. | Toxoplasma gondii is an intracellular protozoan parasite that infects a wide variety of warm-blooded hosts and can have devastating effects in the developing fetus as well as the promised host. An appreciation of how this organism interacts with the host immune system is crucial to understanding the pathogenesis of thi... |
20860482 | Third-generation smallpox vaccines: challenges in the absence of clinical smallpox. | Smallpox, a disease caused by variola virus, is estimated to have killed hundreds of millions to billions of people before it was certified as eradicated in 1980. However, there has been renewed interest in smallpox vaccine development due in part to zoonotic poxvirus infections and the possibility of a re-emergence of... |
20860480 | Type B coxsackieviruses and their interactions with the innate and adaptive immune systems. | Coxsackieviruses are important human pathogens, and their interactions with the innate and adaptive immune systems are of particular interest. Many viruses evade some aspects of the innate response, but coxsackieviruses go a step further by actively inducing, and then exploiting, some features of the host cell response... |
20860483 | Sensing by the membrane-bound sensor kinase DcuS: exogenous versus endogenous sensing of C(4)-dicarboxylates in bacteria. | Bacteria are able to grow at the expense of mon (succinate, L-malate, fumarate and aspartate) and mon (L-tartrate and D-malate) C(4)-dicarboxylates, which ponents of central metabolism. Two types of sensors/regulators responding to the C(4)-dicarboxylates function in Escherichia coli, Bacillus, Lactobacillus and relate... |
20860481 | Immune evasion by Kaposi's sarcoma-associated herpesvirus. | Persistent viral infections are often associated with serious diseases, primarily by altering functions of the host immune system. The hallmark of Kaposi's a-associated herpesvirus (KSHV) infection is the establishment of a life-long persistent infection, which leads to several clinical, epidemiological and infectious ... |
20860484 | The TonB energy transduction systems in Vibrio species. | Studying the organization and conservation of the TonB systems across the genus Vibrio, we can tease out trends in gene arrangement and function that lead to clues about the evolution and necessity of the proteins in multiple TonB systems. The TonB2 systems, with additional TtpC proteins, are in general more promiscuou... |
20860489 | Absent circadian rhythm of proteinuria in hospitalized patients with preeclampsia. | To study the variation of protein excretion in short-interval day-and-night collections in hospitalized preeclamptic patients on continuous bed rest. |
20860490 | A study of lipoproteins in normal and pregnancy induced hypertensive women in tertiary care hospitals of the north west frontier province-Pakistan. | To evaluate the levels of serum lipoproteins in women with pregnancy-induced hypertension pare it with the corresponding levels in pregnant women having normal blood pressure. |
20860486 | Antibiotic resistance in Chlamydiae. | There are few documented reports of antibiotic resistance in Chlamydia and no examples of natural and stable antibiotic resistance in strains collected from humans. While there are several reports of clinical isolates exhibiting resistance to antibiotics, these strains either lost their resistance phenotype in vitro, o... |
20860491 | Thrombophilia mediates lowering cardiovascular risk factors in women with a history of preeclampsia. | Preeclampsia is associated with increased risk of cardiovascular disease. The aim of this pilot study was to assess whether the presence of thrombophilia results in a greater tendency to develop endothelial dysfunction and cardiovascular diseases. |
20860492 | Factors associated with patient understanding of preeclampsia. | To explore the extent to which pregnant women understand the symptoms and plications related to preeclampsia and to determine the factors that are associated with better understanding. |
20860493 | Maternal cerebral blood flow and glucose metabolism in pregnancies complicated by severe preeclampsia. | To investigate maternal cerebral blood flow and glucose metabolism in plicated by severe pared to normal pregnancies. |
20860494 | Does sulfur-hexafluoride tamponade, as an adjunct to vitrectomy and internal-limiting-membrane peeling, suffice for the treatment of retinal detachment associated with macular hole? | To evaluate the efficacy of sulfur hexafluoride tamponade, as an adjunct to vitrectomy and internal-limiting-membrane peeling, for the treatment of retinal detachment (RD) associated with macular hole (MH). |
20860485 | Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses. | Leptospirosis, the most widespread zoonosis in the world, is an emerging public health problem, particularly in large urban centers of developing countries. Several pathogenic species of the genus Leptospira can cause a wide range of clinical manifestations, from a mild, flu-like illness to a severe disease form charac... |
20860495 | Energy metabolism of leukemia cells: glycolysis versus oxidative phosphorylation. | For generation of energy, cancer cells utilize glycolysis more vigorously than oxidative phosphorylation in mitochondria (Warburg effect). We examined the energy metabolism of four leukemia cell lines by using glycolysis inhibitor, 2-deoxy-d-glucose (2-DG) and inhibitor of oxidative phosphorylation, oligomycin. NB4 was... |
20860496 | Low-dose radiation employed in diagnostic imaging causes genetic effects in cultured cells. | Exposure to environmental, diagnostic, and occupational sources of radiation frequently involves low doses. Although these doses have no immediately noticeable impact on human health there is great interest in their long-term biological effects. |
20860497 | Dose levels from thoracic and pelvic examinations in two pediatric radiological departments in Norway - a comparison study of dose-area product and radiographic technique. | pediatric doses expressed in dose-area product (DAP) can be retrieved from only a few publications; most of which correlate DAP to patient size or large age spans. In clinical practice age is often the only available parameter describing the patient, and thus, evaluation of dose levels in pediatric radiology on the bas... |
20860502 | Effect of screening mammography on breast-cancer mortality in Norway. | A challenge in quantifying the effect of screening mammography on breast-cancer mortality is to provide parison groups. The use of historical control subjects does not take into account chronologic trends associated with advances in breast-cancer awareness and treatment. |
20860503 | A large-scale, consortium-based genomewide association study of asthma. | Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked ... |
20860506 | A randomized trial of a telephone care-management strategy. | Studies have shown that telephone interventions designed to promote patients' self-management skills and improve munication can increase patients' satisfaction and their use of preventive services. The effect of such a strategy on health care costs remains controversial. |
20860505 | A randomized study of endobronchial valves for advanced emphysema. | Endobronchial valves that allow air to escape from a pulmonary lobe but not enter it can induce a reduction in lobar volume that may thereby improve lung function and exercise tolerance in patients with pulmonary hyperinflation related to advanced emphysema. |
20860504 | Fondaparinux for the treatment of superficial-vein thrombosis in the legs. | The efficacy and safety of anticoagulant treatment for patients with acute, symptomatic superficial-vein thrombosis in the legs, but without itant deep-vein thrombosis or symptomatic pulmonary embolism at presentation, have not been established. |
20860522 | Comparison of flanged and unflanged acetabular cup design. An experimental study using ceramic and cadaveric acetabuli. | Adequate depth of cement penetration and cement mantle thickness is important for the durability of cemented cups. A flanged cup, as opposed to unflanged, has been suggested to give a more uniform cement mantle and superior cement pressurization, thus improving the depth of cement penetration. This hypothesis was teste... |
20860524 | Review of carbon nanotubes toxicity and exposure--appraisal of human health risk assessment based on open literature. | Carbon nanotubes (CNTs) possess many unique electronic and mechanical properties and are thus interesting for numerous novel industrial and biomedical applications. As the level of production and use of these materials increases, so too does the potential risk to human health. This study aims to investigate the feasibi... |
20860523 | Effect of appetizer administration on plasma leptin level in human volunteers. | The present study aimed at evaluating the effect of appetizer administration on plasma leptin levels of human volunteers. The ginger-based appetizers, namely ginger munch, fruit munch, jeera munch and appetizer drink, developed in the Defence Food Research Laboratory were used for 45 volunteers. Leptin was analyzed usi... |
20860525 | Use of uncertainty factors by the SCOEL in their derivation of health-based occupational exposure limits. | The aim of this study was to investigate how the Scientific Committee on Occupational Exposure Limits (SCOEL) of the European Commission uses uncertainty factors when proposing health-based indicative occupational exposure limit values (IOELVs). In total, 75 IOELVs in 62 summary documents published from 1991 to 2003 we... |
20860526 | Ecology of sexual dimorphism and clinal variation of coloration in a damselfly. | Sexual selection, more so than natural selection, is posited as the major cause of sex differences. Here I show ecological correlations between solar radiation levels and sexual dimorphism in body color of a Hawaiian damselfly. Megalagrion calliphya exhibits sexual monomorphism at high elevations, where both sexes are ... |
20860521 | Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal. | Heme is vital to our aerobic universe. Heme cellular content is finely tuned through an exquisite control of synthesis and degradation. Heme deficiency is deleterious to cells, whereas excess heme is toxic. Most of the cellular heme serves as the prosthetic moiety of functionally diverse hemoproteins, including cytochr... |
20860527 | Synthesis and characterisation of two novel proton transfer compounds and their inhibition studies on carbonic anhydrase isoenzymes. | Two novel proton pounds were prepared between 2,4-dichloro-5-sulphamoylbenzoic acid (lasamide) (Hsba) and ethylenediamine (en), namely ethane-1,2-diaminium 2,4-dichloro-5-sulphamoylbenzoate (1), and also between Hsba and 2-amino-3-methylpyridine (2-amino-3-picoline) (amp), namely 2-amino-3-methylpyridinium 2,4-dichloro... |
20860528 | Managing pain in the workplace: a focus group study of challenges, strategies and what matters most to workers with low back pain. | Most working adults with low back pain (LBP) continue to work despite pain, but few studies have assessed self-management strategies in this at-work population. The purpose of this study was to identify workplace challenges and self-management strategies reported by workers remaining at work despite recurrent or persis... |
20860529 | Efficacy and safety of ritonavir dose reduction based on the tipranavir inhibitory quotient in HIV-infected patients on salvage antiretroviral therapy with tipranavir/ritonavir. | Ritonavir-related adverse events have been reported in patients taking tipranavir/ritonavir at the licensed dosage of 500/200 mg twice daily (bid). The aim of this open-label, prospective, single-arm pilot study was to evaluate the efficacy and safety of a ritonavir dose reduction to 100 mg bid guided by the tipranavir... |
20860530 | Functional polymorphism of the MMP-1 promoter (-1607 1G/2G) in potentially malignant and malignant head and neck lesions in an Indian population. | Matrix metalloproteinases (MMP) are a family of zinc-dependent proteases that degrade the ponent of the extracellular matrix. Our study explores the association of the MMP1 gene promoter (-1607 1G/2G) polymorphisms in oral submucous fibrosis (OSMF) and head and neck squamous cell carcinoma (HNSCC) in an Indian populati... |
20860531 | Interferon-γ and IL-5 production correlate directly in HIV patients co-infected with mycobacterium tuberculosis with or without immune restoration disease. | IL-5 and interferon-γ responses were investigated in mitogen-stimulated whole-blood cultures from HIV patients with and without Mycobacterium tuberculosis disease, to determine whether an imbalance of Th1/Th2 cytokines contributes to susceptibility to M. tuberculosis disease or to immune restoration disease (IRD) assoc... |
20860532 | Incidence of HIV type 1 infection, antiretroviral drug resistance, and molecular characterization in newly diagnosed individuals in Argentina: A Global Fund Project. | An HIV incidence estimation was performed among men who have sex with men (MSM), drug users (DUs), sex workers (SWs), and pregnant women (PW) from Argentina. Volunteers older than 18 years old without a previous HIV-positive diagnosis were included. HIV-positive samples were analyzed by the Serological Testing Algorith... |
20860534 | HIV-1 drug resistance transmission networks in southwest Switzerland. | To determine viral subtypes and resistance mutations to antiretroviral treatment (ART) in untreated HIV-1 acutely infected subjects from Southwest Switzerland. Clinical samples were obtained from the HIV primary infection cohort from Lausanne. Briefly, pol gene was amplified by nested PCR and sequenced to generate a 1 ... |
20860533 | Oral mucoceles and ranulas may be part of initial manifestations of HIV infection. | It is well documented and generally accepted that enlargement of parotid salivary glands, as part of HIV-related salivary gland diseases (HIV-SGD), may be the initial symptoms/manifestations of the HIV infection. Oral mucoceles and ranulas are also frequently described as oral manifestations, in association with HIV in... |
20860536 | The pivotal role of VEGF in adipose-derived-stem-cell-mediated regeneration. | Several lines of evidence suggest that VEGF is a key regulator of the paracrine effects of adipose-derived stem cells (ASCs), but the mechanism of action remains to be identified. |
20860537 | Doubling of water intake increases daytime blood pressure and reduces vertigo in healthy subjects. | We studied the effect of increased water intake on ambulatory blood pressure (BP) in healthy individuals. Blood pressure was recorded after 2 weeks of either regular (RWI) or extra water intake (EWI, an additional 30 ml water/kg body weight per day) in 20 healthy subjects (10 males, 10 females). The extra water intake ... |
20860539 | Novel technologies to detect atelectotrauma in the injured lung. | Cyclical recruitment and derecruitment of lung parenchyma (R/D) remains a serious problem in ALI/ARDS patients, defined as atelectotrauma. Detection of cyclical R/D to titrate the optimal respiratory settings is of high clinical importance. Image-based technologies that are capable of detecting changes of lung ventilat... |
20860540 | Low-molecular-weight heparins do not modify obliterative airway disease in rat tracheal allografts. | Immunosuppressive and antiproliferative effects of heparin may be beneficial in the field of solid organ transplantation. The aim of this study was to examine the effect of low-molecular-weight heparin pounds on the development of obliterative airway disease (OAD) in the rat tracheal transplant model. Allogenic heterot... |
20860538 | Deficiency of matrix metalloproteinase-13 increases inflammation after acute lung injury. | Human and animal studies of acute lung injury (ALI) have shown that matrix metalloproteinases (MMPs) play an important role in disease pathogenesis, but despite being detected during ALI, the function of the collagenase MMP-13 in ALI is unknown. To evaluate this role of MMP-13, mice deficient in MMP-13 (KO) were examin... |
20860541 | Growth differentiation factor 15 in different stages of heart failure: potential screening implications. | Identification of individuals in the early stage of heart failure (HF) may allow earlier initiation of disease-modifying treatment. We evaluated concentrations of the growth differentiation factor (GDF)-15 at different stages and its potential screening value in 208 subjects. Plasma GDF-15 was measured by using an enzy... |
20860542 | Low-level laser therapy with a pulsed infrared laser accelerates second-degree burn healing in rat: a clinical and microbiologic study. | This study was carried out to investigate the influence of pulsed-wave low-level laser therapy (LLLT) on the healing of a deep second-degree burn model in rat. |
20860543 | Inflammation and immune response in acute aortic dissection. | The aim of our study was to evaluate the lymphocyte subpopulations and the cytokines in the peripheral blood of patients with type-A Stanford acute aortic dissection (AAD group) and to determine whether inflammatory cells are present at the site of aortic dissection. |
20860544 | Severe laryngeal dysplasia in a 20-year-old nonsmoker treated with CO2 laser excision: a case report and review of the literature. | We present the unusual case of a 20-year-old female nonsmoker with severe laryngeal dysplasia managed with endoscopic CO(2) laser resection with frozen-section analysis. We use her case as a platform for discussion of the current evidence surrounding laryngeal dysplasia, particularly etiology and the use of lasers in m... |
20860545 | Investigation of coronal leakage of root fillings after smear-layer removal with EDTA or Nd:YAG lasing through capillary-flow porometry. | This study investigates the effects of Nd:YAG laser bined with different irrigation protocols on the marginal seal of root fillings. |
20860547 | Current and new cytomegalovirus antivirals and novel animal model strategies. | Cytomegalovirus (CMV) is a significant health problem among immunosuppressed individuals. In particular, transplant and AIDS patients and the developing fetus in utero are highly susceptible to CMV. In these vulnerable populations, infection leads to life threatening end organ viral disease or in surviving newborn babi... |
20860548 | Drugs acting on mast cells functions: a cell biological perspective. | Mast cells are bone marrow derived cells capable of secreting many active molecules: mediators stored in specific granules, such as histamine and heparin; small molecules produced immediately upon stimulation, such as lipid derivatives and nitric oxide; and many constitutively secreted, pleiotropic cytokines. Thanks to... |
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