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22099770 | Cellular immunoisolation for islet transplantation by a novel dual porosity electrospun membrane. | Immunoisolation strategies have the potential to impact the treatment of several diseases, such as hemophilia, Parkinson's and endocrine disorders, such as parathryroid disorders and diabetes. The hallmark of these disease states is the amelioration of the disease process by replacement of the deficient protein. Natura... |
22099774 | Effect of tacrolimus versus cyclosporine on glucose metabolism of pancreas and kidney recipients in the late (> 8 years) posttransplant period. | Diabetogenic effects of immunosuppressive agents are of great importance in pancreas or islet transplantation. The aim of our study was pare the glucose metabolism in type 1 diabetic kidney and pancreas recipients on tacrolimus (Tacro) versus cyclosporine-based (Cyclo) immunosuppression in the late posttransplant perio... |
22099772 | Function and viability of human islets encapsulated in alginate sheets: in vitro and in vivo culture. | Islet encapsulation offers an immune system barrier for islet transplantation, and encapsulation within an alginate sheetlike structure offers the ability to be retrievable after transplanted. This study aims to show that human islets encapsulated into islet sheets remain functional and viable after 8 weeks in culture ... |
22099775 | Evaluation of segmental pancreatic function using 11C-methionine positron emission tomography for safe living donor operation of pancreas transplantation. | For a safe living pancreas donoration for transplantation, we evaluated the function of the residual pancreas head using 11C-methionine positron emission tomography (PET) in 13 cases before and after distal pancreatectomy. After 6 hours of fasting, we intravenously administered 11C-methionine (370 to 740 MBq), performi... |
22099777 | Assessment of mitochondrial DNA as an indicator of islet quality: an example in Goto Kakizaki rats. | Diabetic Goto Kakizaki (GK) rats represent an established model of type 2 diabetes that exhibit an onset of pancreatic islet (PI) pathology characterized by islet hypertrophy with a decreased number of insulin-secreting β-cells. Among the remaining β-cells, oxidative phosphorylation (OXPHOS) and consequently glucose-st... |
22099776 | Immunoregulatory effect of anti-thymocyte globulin monotherapy on peripheral lymphoid tissues of non-obese diabetic mice. | Experimental and clinical studies have shown that autoimmunity-causing diabetes may be abrogated by immune intervention. Several anti-T-lymphocyte antibodies focus on distinct T-cell targets. We tested the effect of murine anti-thymocyte globulin (ATG; Genzyme, Framingham, MA) in peripheral lymphoid organs of non-obese... |
22099778 | FTY720-loaded poly(DL-lactide-co-glycolide) electrospun scaffold significantly increases microvessel density over 7 days in streptozotocin-induced diabetic C57b16/J mice: preliminary results. | Nanofiber scaffolds could improve islet transplant success by physically mimicking the shape of extracellular matrix and by acting as a drug-delivery vehicle. Scaffolds implanted in alternate transplant sites must be prevascularized or very quickly vascularized following transplantation to prevent hypoxia-induced islet... |
22099779 | Neoplasm incidence in simultaneous pancreas and kidney transplantation: a single-center analysis. | Long-term immunosuppression is associated with an increased rate of cancer. The aim of this study was to analyze the incidence of newly diagnosed tumors in simultaneous kidney and pancreas transplantation (SPKT). |
22099780 | Nonmarginal-donor duodenal ulcers caused by rejection after simultaneous pancreas and kidney transplantation: a case report. | Pancreas transplantation has been associated with the highest plication rate among routinely performed organ transplant procedures. Complications can be caused not only from the pancreas itself but also from the simultaneously transplanted duodenum: gastrointestinal bleeding, duodenal ulcer, pseudoaneurysm, arterioente... |
22099781 | Resolution of long-standing necrobiosis lipoidica diabeticorum (NLD) lesion after restoration of euglycemia following successful pancreas after kidney (PAK) transplantation: a case report. | Necrobiosis lipoidica diabeticorum (NLD) is an inflammatory skin disorder of unknown cause which can be seen in patients with diabetes mellitus. Various treatments, including immunosuppressive agents have been tried, without consistent efficacy. NLD is generally thought not to correlate well with tight diabetic control... |
22099782 | Rituximab therapy and reduction of immunosuppression to rescue graft function after renal posttransplantation lymphoproliferative disorder found by macrohematuria in a pancreas and kidney transplant recipient: a case report. | Posttransplantation lymphoproliferative disorder (PTLD) remains an plication of solid organ transplantation, with a high mortality rate reported after conventional therapies. Epstein-Barr virus (EBV) may cause PTLD, but most EBV infections after transplantation are clinically silent reactivations, so the detection of P... |
22099783 | Hypersensitivity to rabbit antithymocyte globulin in an islet transplant recipient: a case report. | The aim was to describe a case of hypersensitivity to rabbit antithymocyte globulin (rATG) occurring in the context of islet transplantation. |
22099785 | Organizational model for a national system of donation and transplantation from deceased donors in Nicaragua. | System organization is one of the principal elements for success of a country's donation and transplantation activities. Nicaragua still does not have a specific institution that organizes and coordinates donation and transplantation; it does not perform transplantations from brain dead donors. With the counsel of the ... |
22099786 | Expanded criteria donors, histological scoring, and prolonged cold ischemia: impact on renal graft survival. | The use of expanded donors or kidneys with preexistent chronic damage remains controversial, but they offer the opportunity to expand the donor pool. We investigated the impact of these conditions as predictors of graft survival among a cohort of recipients with prolonged cold ischemia times and a high incidence of del... |
22099787 | Short-term immunossupressive treatment of the donor does not prevent ischemia-reperfusion kidney damage in the rat. | Ischemia-reperfusion (IR) kidney damage is an important factor for allograft survival in kidney transplantation. Recently it has been shown that immune factors from donor-derived cells are important in IR injury. The aim of this article was to evaluate the impact of short-term immunosuppressive treatment of the donor o... |
22099788 | Minor histocompatibility antigens as risk factor for poor prognosis in kidney transplantation. | Progress in transplantation has relied on similar human leukocyte antigen (HLA) matching between the donor and the patient, while the role of other immunologic factors like non-HLA markers including minor patibility antigens (miHA) are currently in the forefront. miHA are polymorphic proteins that vary even in monozygo... |
22099789 | Effect of implementing anti-HLA antibody detection by Luminex in the kidney transplant program in Chile. | The development of new highly sensitive, specific technologies to detect HLA antibodies has allowed a better definition of the profile of non-permitted antigens for patients awaiting kidney transplantation. The use of calculated or virtual panel reactive antibodies (CPRA or vPRA) seeks to improve the prediction of posi... |
22099790 | A comparative study of the traditional method, and a point-score system for allocation of deceased-donor kidneys: a national multicenter study in Mexico. | The National Transplant Center in Mexico has ruled that deceased-donor kidney allocation is a function of each hospital's Internal Transplant Committee. The aim of this study was pare and analyze results for of the traditional method and a point-score system in the allocation of deceased patient's kidneys. |
22099791 | De novo use of everolimus with elimination or minimization of cyclosporine in renal transplant recipients. | The purpose of two similarly designed multicenter, prospective, parallel-group, open-label studies was to evaluate early cyclosporine (CsA) elimination versus minimization from an everolimus-CsA-steroid regimen in de novo renal transplant patients. |
22099792 | Utilization of advanced-age donors in renal transplantation. | The shortage of organ availability in recent years has made it necessary to use grafts from advanced-aged donors to maintain the rate of renal transplantation in our country. The objective of this study was to evaluate the graft function and patient survival using kidneys from deceased donors of over 65 year of age. Fr... |
22099793 | Growth, chronic kidney disease and pediatric kidney transplantation: is it useful to use recombinant growth hormone in Colombian children with renal transplant? | Kidney transplantation has e the best treatment for children with chronic kidney disease (CKD). In recent times, knowledge concerning the effect of CKD and kidney transplantation over the normal growth rate has increased; now it is known that 40% of children with CKD do not reach the expected height for age. Growth ret... |
22099794 | Clinical description and evolution of renal transplant pediatric patients treated with alemtuzumab. | Renal transplantation is the most effective treatment for children with end-stage renal disease. Recent work suggests that induction with alemtuzumab in the pediatric population permits the use of lower doses of maintenance immunosuppressive therapy. In addition, it has a low pared with other induction therapies. |
22099795 | Preemptive kidney transplantation: experience in two centers. | End-stage renal disease (ESRD) is a prevalent, important cause of death. Transplantation increases survival and improves the quality of life of patients with ESRD while long-term dialysis is related to poor es even among patients who undergo subsequent transplantations. |
22099796 | Induction therapies in kidney transplantation: the experience of Hospital Pablo Tobon Uribe, Medellín, Colombia 2005-2010. | Induction therapies in kidney transplantation have led to prescriptions of lower doses of maintenance immunosuppression and fewer acute rejection episodes. We sought to assess the use of an affordable monoclonal antibody in terms of the incidences of rejection episodes as well as graft and patient survivals and cytomeg... |
22099797 | Barriers and strategies for taking medicines in adult patients with renal transplantation. | Adherence to the immunosuppressant medications is important for the proper function a renal graft, but there are factors that make this difficult. This study describes strategies and barriers to adequate intake of these medicines based upon 177 surveys in renal transplant patients. Medication adherence was reported to ... |
22099798 | Cost-effectiveness analysis of the early conversion of tacrolimus to mammalian target of rapamycin inhibitors in patients with renal transplantation. | Renal replacement therapies which consist of renal transplantation and dialysis are the only treatment options for patients with terminal renal failure. These therapies have changed the e from being fatal to being a chronic disease. Kidney transplantation involves the use of immunosuppressive agents to prevent rejectio... |
22099799 | Cutaneous manifestations in 100 renal and reno-pancreatic recipients of Uruguay. | Uruguay is the second country of Latin America in prevalence of renal replacement therapies, including functioning kidney allografts. Long-term immunosuppressive therapy is essential for adequate graft function, but results in reduced immunosurveillance leading to an increased risk plications such as infections and mal... |
22099800 | Significance of cytomegalovirus prophylaxis strategies and development of cancer in kidney transplant recipients. | Cytomegalovirus (CMV) infection is one of the plications among kidney transplant recipients; two approaches preventing plication are currently available: universal prophylaxis (UP) and pre-emptive therapy (PT). Despite some differences, similar effectiveness and safety have been proven in several studies for both strat... |
22099801 | Outpatient renal needle biopsy of the transplanted kidney: safety profile. | Since May 2005, we began performing renal graft biopsies as outpatient procedures when the patient's condition did not require hospitalization. To evaluate the safety profile of the 137 procedures performed in 111 patients, we performed a retrospective analysis plications after all biopsies between 4 May 2005 and 6 Jan... |
22099803 | Current practices of organ donation and transplantation among different French-speaking countries and regions. | The aim of the "Transplantation Sans Frontières" (TSF) questionnaire, which was sent to French-speaking centers in 6 different countries and regions, was to establish the current status of organ donation and transplantation in their environments. It was also to examine ways to collaborate and exchange scientific inform... |
22099804 | Donor advocacy with special reference to Belgium. | Before any published Belgian law, EU Directive, and/or EU Action Plan, the donor advocate was naturally a member of the transplantation team performing living kidney donation. The need of donor advocacy appeared obvious with liver living donation, which was and is still a risky procedure. Today, it is clear that the do... |
22099805 | Organ procurement from donors deceased from cardiac death: a single-center efficiency assessment. | Organ donation after cardiac death has been used for kidney and liver procurement in France since 2006. Until recently, most teams relied on in situ cold perfusion to prepare the donor before organ retrieval. Our team has used since 2007 normothermic abdominal recirculation. While this technique is presumed to be more ... |
22099807 | Liver preservation with SCOT 15 solution decreases posttransplantation cholestasis compared with University of Wisconsin solution: a retrospective study. | SCOT 15 is a new solution to preserve abdominal organs for transplantation. Its principal characteristic is the use of polyethylene glycol. Herein We report our experience using SCOT pared with the reference University of Wisconsin (UW) solution for hepatic transplantation. |
22099808 | Landmarks in clinical solid organ transplantation in Vietnam. | Renal transplantation was first performed in Vietnam in 1992. Up to the end of 2010, there have been 400 kidney and 16 liver transplantations from related and unrelated living donors. From 8 brain-dead donors between 2008 and 2010, we performed 15 kidney, 1 liver, and 1 heart transplantation. Few people agree to donate... |
22099806 | Pancreas preservation for pancreas and islet transplantation: a minireview. | Pancreas preservation by cold storage using University of Wisconsin solution was the mainstay method used for pancreas transplantation during the past 2 decades. Other solutions, such as HTK, Celsior, and SCOT 15, could not demonstrate any advantage for short preservation periods. But the advent of clinical islet trans... |
22099809 | Impact of pretransplant human leukocyte antigen-C and -DP antibodies on kidney graft outcome. | The aim of our study was to determine whether the presence of specific human leukocyte antigen (HLA)-C and -DP antibodies before transplantation influenced graft es in immunized recipients. Two groups of pretransplant immunized recipients were studied: patients with only classical HLA-A, -B, -DR, -DQ antibodies (n = 17... |
22099810 | Use of elderly living kidney donors: twenty years' experience in the Balkans. | The Balkan region has dramatically changed during the last 20 years. Despite transplantation efforts, dialysis remains the usual way to treat end stage renal diseases. Living donor renal transplantation is still the predominant transplant activity. Seeking to solve the problem, we decided to accept expanded criteria li... |
22099811 | Increased body mass index after kidney transplantation in activating transcription factor 6 single polymorphism gene carriers. | Endoplasmic reticulum stress has been implicated in the pathogenesis of new-onset diabetes after transplantation (NODAT) and of metabolic disorders. Activated Transcription Factor 6 (ATF6), which is activated during endoplasmic reticulum stress, is involved in lipogenesis and gluconeogenesis. Tacrolimus may induce endo... |
22099812 | Does kidney transplantation with multiple arteries affect graft survival? | pared short- and long-term es of renal transplants with single versus multiple arteries. |
22099814 | The first two cadaveric renal transplantations in Blida, Algeria. | Currently, living related donor renal transplantation is the mon source for transplantation in Algeria. To develop cadaveric organ donation, the Blida Transplantation Team (BTT) started a local education program and campaign. On March 31, 2010, we procured and transplanted 2 kidneys from a 17-year-old brain-dead donor.... |
22099813 | Xenotransplantation of galactosyl-transferase knockout, CD55, CD59, CD39, and fucosyl-transferase transgenic pig kidneys into baboons. | Galactosyl-transferase knockout (GT-KO) pigs represent the latest major progress to reduce immune reactions in xenotransplantation. However, their organs are still subject to rapid humoral rejection plement activation requiring the ongoing development of further genetic modifications in the pig. In a pig-to-baboon rena... |
22099816 | End of life care in the operating room for non-heart-beating donors: organization at the University Hospital of Liège. | Non-heart-beating (NHB) organ donation has e an alternative source to increase organ supply for transplantation. A NHB donation program was implemented in our institution in 2002. As in many institutions the end of life care of the NHB donor (NHBD) is terminated in the operating room (OR) to reduce warm ischemia time. ... |
22099817 | Hypothermic machine perfusion of the liver: is it more complex than for the kidney? | Hypothermic machine perfusion (HMP) is superior to simple cold storage (SCS) for the preservation of kidney grafts. Whether HMP is superior to SCS for liver preservation is not known. Before a HMP system can be used clinically for the liver, its superiority to SCS needs to be demonstrated in an in vivo large animal tra... |
22099818 | Presumed and actual concentrations of reduced glutathione in preservation solutions. | Reduced glutathione (GSH), an important radical scavenger, has been added to various organ preservation solutions. Because GSH oxidizes into oxidized glutathione (GSSG) and only GSH has scavenging capacity, only GSH in the solution at the time of clinical use is relevant. The concentrations of GSH (GSH(conc)) and GSSG(... |
22099819 | Attempt to rescue discarded human liver grafts by end ischemic hypothermic oxygenated machine perfusion. | In a porcine liver transplant model, a brief period of oxygenated hypothermic machine perfusion (HMP) at the end of simple cold storage (SCS) has been shown to improve the viability of damaged liver grafts. To test the clinical validity of this strategy, we randomized SCS-discarded human liver grafts to either 4 hours ... |
22099820 | Differential gene expression profile of porcine livers subjected to warm ischemia alone. | Livers exposed to warm ischemia (WI) are increasingly used for transplantation. The molecular mechanisms activated by WI alone (prior to procurement and transplantation) are not understood. To elucidate the pathways involved, we used microarrays to investigate the gene expression in porcine livers exposed to WI. |
22099821 | Incidence and risk factors for posttransplant subcapsular cataract: a long-term retrospective cohort study. | The occurrence and risk factors for posterior subcapsular cataract (PSC) after renal transplantation have received little attention. |
22099822 | Long-term evolution of the mineral metabolism after renal transplantation: a prospective, single-center cohort study. | Abnormalities in bone and mineral metabolism mon after renal transplantation (RT) but information on their long-term time course is scarce. |
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