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16113533 | Attitudes about genetics in underserved, culturally diverse populations. | New medical discoveries regarding genetic susceptibility mon chronic diseases, and the decoding of the human genome have increased public attention to genetics. What information is understood and what attitudes exist towards genetics and genetic research have not been well examined in underserved, culturally munities. |
16113534 | Prevalence of three hereditary hemochromatosis mutant alleles in the Michigan Caucasian population. | To investigate the prevalence in the Michigan non-Hispanic Caucasian population of the C282Y, H63D and S65C mutations in the HFE gene associated with hereditary hemochromatosis. |
16113535 | Prevalence of eNOS Glu298Asp polymorphism in healthy volunteers from a region of Northern India. | Endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphisms are under extensive study worldwide due to their suggested role in cardiovascular disorders. This polymorphism had gained more attention since several reports suggest its association with hypertension and coronary artery disease (CAD). Asian Indians are h... |
16113536 | United Arab Emirates: communities and community genetics. | The UAE society is cosmopolitan, but the indigenous inhabitants are traditional with puritanical values despite their exposure to other vastly different cultures and habits. Marriages between consanguineous couples are still the norm rather than the exception. As a result, there is a high frequency of genetic disorders... |
16113537 | Effects of different titanium alloys and nanosize surface patterning on adhesion, differentiation, and orientation of osteoblast-like cells. | To test nanosize surface patterning for application as implant material, a suitable position has to be found first. Therefore we investigated the effect of surface chemistry on attachment and differentiation of osteoblast-like cells on pure titanium prepared by pulsed laser deposition (TiPLD) and different Ti alloys (T... |
16113538 | Identification and functional characterization of the muscarinic receptor M3 in the human keratinocyte cell line HaCaT. | In the epidermis muscarinic cholinergic receptors are expressed in keratinocytes during normal differentiation and in regeneration of the skin. The muscarinic receptors were implicated to regulate proliferation, migration and differentiation of keratinocytes. Therefore, we characterized the muscarinic receptor in the s... |
16113539 | Identification of myosin heavy chain I, IIa and IIx in canine skeletal muscles by an electrophoretic and immunoblotting study. | To determine which myosin heavy chain (MHC) isoforms are expressed in canine skeletal muscles, different muscle samples of five mixed-breed dogs were analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). The separated MHC isoforms were identified by immunoblotting technique using a set of s... |
16113540 | Ultrastructural identification of a sympathetic component in the hypoglossal nerve of hamsters using experimental degeneration and horseradish peroxidase methods. | We employed experimental degeneration, tract-tracing with wheatgerm agglutinin conjugated with horseradish peroxidase (WGA-HRP) and electron microscopy to explore the postganglionic sympathetic fibers in the hypoglossal nerve of hamsters. Quantitative results of normal untreated animals at the electron microscopic leve... |
16113541 | A morphometric study of age-related changes in adult human epiglottis using quantitative digital analysis of cartilage calcification. | The epiglottis plays an important role in deglutition in humans. The present study investigated age-related changes in the epiglottis using macroscopic and microscopic measurements. Epiglottic specimens from 281 Japanese adult cadavers (177 males, 104 females) were obtained. Specimens were divided into three groups acc... |
16113543 | Probiotics as a treatment strategy for gastrointestinal diseases? | Current interest in probiotics is motivated not only by the clinical data showing efficacy of some probiotic bacteria but also by the increasing antibiotic resistance of pathogenic bacteria (particularly in hospitals) and the rise of consumers' demand for natural substitutes of drugs. Only few randomized, double-blind ... |
16113542 | Is Lactobacillus rhamnosus GG effective in preventing the onset of antibiotic-associated diarrhoea: a systematic review. | To evaluate the efficacy of Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea. |
16113545 | Follow-up of exocrine pancreatic function in type-1 diabetes mellitus. | In a previous study, mild to moderate exocrine pancreatic insufficiency, as measured by the secretin-pancreozymin test, was found in 23 (43%) of 53 patients with type-1 diabetes mellitus. Of these 53 patients, 20 (7 of whom initially had an abnormal secretin-pancreozymin test) were available for a follow-up examination... |
16113546 | On-demand therapy with pantoprazole 20 mg as effective long-term management of reflux disease in patients with mild GERD: the ORION trial. | pare safety and efficacy of on-demand pantoprazole 20 mg/40 mg versus placebo in the long-term management of patients with mild gastroesophageal reflux disease (GERD) after heartburn relief. |
16113548 | Automatic computerized diagnosis of fetal sinusoidal heart rate. | Computerized automatic detection of pathologic fetal sinusoidal heart rate (FSHR) and its differentiation from physiologic FSHR is the purpose of this study. The results will be applied in the objective evaluation of fetal heart rate (FHR) with artificial neural puter. |
16113554 | Effects on the maternofetal unit of the rabbit model after substitution of the amniotic fluid with perfluorocarbons. | Exchanging amniotic fluid (AF) with perfluorocarbon (PFC) may serve as a medium for fetoscopic surgery. This study evaluates the distribution and physiologic effects of intraamniotic PFC as a medium for fetoscopy. |
16113552 | Increased C282Y heterozygosity in gestational diabetes. | Hereditary hemochromatosis is an autosomal recessive disorder of iron metabolism that is characterized by excess accumulation of iron in various organs and often leads to diabetes mellitus (DM). To study whether mutations in the hemochromatosis gene (HFE) could be a risk factor for the development of gestational diabet... |
16113547 | Parental decision-making after ultrasound diagnosis of a serious foetal abnormality. | The purpose of this article is to provide clinicians who are involved in the field of foetal medicine with prehensive overview of theories that are relevant for the parental decision-making process after ultrasound diagnosis of a serious foetal abnormality. |
16113549 | In utero repair of an experimental neural tube defect in a chronic sheep model using biomatrices. | Persistent exposure of the unprotected spinal cord to amniotic fluid and the uterine wall can lead to progressive damage of neural tissue in case of a myelomeningocele (two-hit hypothesis). The aim of this study was to evaluate whether in utero repair of an experimental neural tube defect in a fetal lamb could protect ... |
16113556 | Effect of betamethasone administration on fetal heart rate tracing: a blinded longitudinal study. | Computerized fetal heart rate (FHR) analysis revealed that antenatal corticosteroids transiently suppress multiple parameters of fetal well-being, potentially leading to the erroneous diagnosis of fetal distress and to unnecessary iatrogenic delivery of premature infants. Our aim was to determine whether clinicians who... |
16113550 | Reassuring fetal middle cerebral artery doppler velocimetry in alloimmunised pregnancies: neonatal outcomes without invasive procedures. | To assess the neonatal e in red blood cell alloimmunised pregnancies at increased risk of fetal anaemia where invasive testing was avoided based on reassuring middle cerebral artery (MCA) Doppler velocity results. |
16113562 | Coelomic fluid leptin concentration in normal first-trimester pregnancies and missed miscarriages. | Investigation of the possible role of leptin in early pregnancy failure. |
16113551 | Omphalocoele-exstrophy-imperforate anus-spinal defects complex in dizygotic twins. | plex refers to bination of defects consisting of omphalocoele, exstrophy of the cloaca, imperforate anus, and spinal defects. The incidence of the plex is very rare, estimated to occur in 1 of 200,000-400,000 pregnancies. The aetiology of the plex is still unclear, single defects in blastogenesis and mutations in homeo... |
16113553 | Identification of maternal hematopoietic cells in a 2nd-trimester fetus. | To study the subset of maternal cells in fetal tissue in a 2nd-trimester fetus with malformations. |
16113555 | Predicting outcome in primary fetal hydrothorax. | This study examines the role of serial ultrasound in predicting fetal es based on progress, resolution or stability of pleural effusions in primary fetal hydrothorax (PFHT). |
16113560 | Diagnosis and management of Rh alloimmunization. | To assess the current problem of alloimmunization in a tertiary referral center in Croatia. The results obtained pared to data published worldwide. |
16113558 | Ductus venosus blood flow velocity waveforms as a predictor for fetal outcome in isolated congenital heart disease. | To investigate whether pulsatility of ductus venosus (DV) flow velocity waveforms is of diagnostic value in predicting survival in fetuses with congenital heart disease (CHD). |
16113557 | Effects of cafedrine/theodrenaline, etilefrine and ephedrine on uterine blood flow during epidural-induced hypotension in pregnant sheep. | Maternal hypotension is a major concern in obstetric anesthesia, and concerns have been raised about standard vasopressor therapy with ephedrine. Therefore, we evaluated the maternal and fetal hemodynamic effects of two potential alternatives to ephedrine. |
16113561 | Prenatal diagnosis and management of fetal xerocytosis associated with ascites. | To discuss the prenatal diagnosis and management of fetal xerocytosis associated with ascites. |
16113565 | The Role of RCAS1 and oxytocinase in immune tolerance during pregnancy. | To determine pare the level of RCAS1 (receptor-binding cancer antigen expressed in SiSo cells) in placentas at term as well as oxytocinase/cystine amino peptidase (CAP) serum level a few days before labor in order to evaluate their possible role in the regulation of maternal immune response during pregnancy and in init... |
16113567 | Fetal intravascular transfusion for hydropic disease due to rhesus isoimmunization. | To evaluate the management of hydropic fetuses, due to rhesus isoimmunization, with fetal intrauterine intravascular transfusions. |
16113563 | Short rib polydactyly syndrome type 3 with absence of fibulae (Verma-Naumoff syndrome). | Short rib polydactyly syndrome (SRPS) is a group of skeletal dysplasias manifested by short-limb dwarfism, short ribs with thoracic dysplasia and polydactyly. SRPS is an inherited autosomal-recessive disorder with different prenatal sonographic and postnatal clinical, histological and radiologic findings. SRPS type 1 (... |
16113569 | Infiltrative breast cancer during pregnancy and conservative surgery. | Mastectomy is considered as the standard therapy for gestational breast cancer. Since radiation therapy is harmful for the fetus, conservative surgery is rarely used during pregnancy. Among 16 patients with gestational breast cancer, 10 and 6 were treated with conservative surgery and mastectomy, respectively. No local... |
16113559 | Sudden death because of massive pulmonary thromboembolism and concomitant cerebrovascular trophoblastic embolism following artificial abortion. | A rare case of sudden death due to cerebral embolization of trophoblastic tissue and itant massive pulmonary embolization following artificial abortion in a 42-year-old woman with poorly regulated hypertension and chronic smoking is described. Histopathological analysis showed syncytiotrophoblast cells, positive on hPL... |
16113579 | Oronasopharyngeal suction versus no suction in normal and term infants delivered by elective cesarean section: a prospective randomized controlled trial. | There are controversies about the routine use of oronasopharyngeal suction (ONPS) in healthy infants. This study aimed pare the effects of oronasopharyngeal suction with those of no suction in normal, term infants delivered by cesarean section. |
16113568 | Arnold-Chiari in a fetal rat model of dysraphism. | Dysraphism is a defect in neural tube development, leading to dysplastic growth of the spinal cord and meninges. Myelomeningocele (MM) is just one of its forms. Hydrocephalus is among the most important alterations in MM and occurs as a consequence of Arnold-Chiari malformation (AC). Experimental models have been devel... |
16113574 | Escherichia coli septic shock following second-trimester amniocentesis. | Genetic amniocentesis is considered a safe procedure with a low incidence plications including infection. |
16113576 | Uterine rupture during second trimester abortion with misoprostol. | Data are limited regarding the use of misoprostol in the midtrimester, therefore few cases with uterine rupture during the second trimester with a previous uterine scar have been reported in the literature. |
16113580 | Endocrine abnormalities in patients with frontoethmoidal encephalomeningocele. A preliminary study. | Frontoethmoidal encephalomeningocele (FEEM) is a congenital neural tube defect which is mon in Southeast Asia. Its etiology is unknown. No one has ever reported endocrine abnormalities in this condition. |
16113582 | Psychosocial functioning of adolescents with idiopathic short stature or persistent short stature born small for gestational age during three years of combined growth hormone and gonadotropin-releasing hormone agonist treatment. | To examine psychosocial functioning of medically referred adolescents with idiopathic short stature (ISS) or persistent short stature born small for gestational age (SGA) during 3 years bined growth hormone (GH) and gonadotropin-releasing hormone agonist (GnRHa) treatment. |
16113570 | Fetal hydrocephalus and intrauterine cerebral ventriculoscopy: an animal model. | The aim of this study was to create an animal model of obstructive ventriculomegaly in the fetal lamb at 78 days of gestation by injecting maternal blood into the lateral ventricles under ultrasound guidance. |
16113577 | Congenital cystic adenomatoid malformation in the fetus: a hypothesis of its development. | We present a case of congenital cystic adenomatoid malformation of the lung diagnosed at 34 weeks of gestation in the setting of polyhydramnios. The fetus had CCAM in the L lung, with mediastinal shift to the right and ascites. The neonate underwent drainage of cysts and subsequent left lung lobar resection with improv... |
16113583 | Impaired coronary flow reserve in hemodialysis patients: a transthoracic Doppler echocardiographic study. | Coronary flow reserve (CFR) reflects the functional capacity of microcirculation to adapt to blood demand during increased cardiac work. In this study, CFR of hemodialysis patients with angiographically normal coronary arteries was evaluated using transthoracic second harmonic Doppler echocardiography. |
16113572 | Is conservative management of prenatal and neonatal ovarian cysts justifiable? | To evaluate conservative management of fetal and neonatal ovarian cysts. |
16113581 | IGF-I and IGF binding protein-3 levels during initial GH dosage step-up are indicators of GH sensitivity in GH-deficient children and short children born small for gestational age. | A stepwise increment of the GH dose is an approach aimed at avoiding adverse events. We investigated GH sensitivity by studying IGF-I and IGFBP-3 concentrations during the initial phase of GH treatment. |
16113566 | Plasma atrial natriuretic peptide in fetuses with cardiac disease. | To investigate atrial natriuretic peptide (ANP) levels in fetuses with cardiac defects and to evaluate the relationships between plasma ANP levels and the presence of polyhydramnios. |
16113564 | Development of a new model to investigate the fetal nociceptive pathways. | The aim of the study was to develop an experimental model to investigate the fetal nociceptive pathways and fetal analgesia. |
16113584 | Influence of apolipoprotein E genotype on progression of diabetic nephropathy. | Diabetic nephropathy progresses at a variable rate part of which may be explained by genetic polymorphisms. ApoE polymorphisms are associated with progression of atherosclerosis and because of the similarities between atherosclerosis and glomerulosclerosis, we chose to examine apoE and its role in progression of diabet... |
16113571 | Relationship between oxidative stress in cord blood and route of delivery. | To investigate the effect of route of delivery on the antioxidant system of newborns. |
16113573 | Successful management of supraventricular tachycardia in a fetus using fetal magnetocardiography. | We report a fetus at 33 weeks of gestation with supraventricular tachycardia, which was successfully managed by transplacental administration of an antiarrhythmic agent. Fetal magnetocardiography (fMCG) revealed supraventricular tachycardia of the long RP' tachycardia type. Transplacental administration of sotalol, ins... |
16113585 | Biology of vascular calcification in renal disease. | The high rates of atherosclerotic vascular disease in patients with end-stage renal disease (ESRD) cannot be fully explained by the excess of traditional risk factors. Interest has therefore arisen in the possible role of vascular calcification, which is increased in these patients and may effect plaque stability and h... |
16113586 | Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat. | Thyroid hormones play a crucial role in new neuron production and maturation during brain development. However, the knowledge about the involvement of these hormones on adult neurogenesis is still plete. Hippocampus is an anatomical region where neurogenesis occurs throughout adulthood and where high levels of thyroid ... |
16113578 | Preliminary investigations into a new method of functional assessment of the fetal heart using a novel application of 'real-time' cardiac magnetic resonance imaging. | Because of quantitative echocardiographic limitations of fetal ventricular volumes as well as poor windows, we sought to determine if real-time magnetic resonance imaging (MRI) could be used. |
16113588 | Renal handling of NH3/NH4+: recent concepts. | To be appropriately excreted in urine, NH4+, the ponent of urinary acid excretion, must be synthesized by proximal tubular cells, secreted into the proximal tubular fluid, reabsorbed by the medullary thick ascending limb (MTAL) to be accumulated in the medullary interstitium, and finally secreted in medullary collectin... |
16113587 | Galanin-Like peptide elicits a robust discharge of growth hormone in the rhesus monkey (Macaca mulatta). | Galanin-like peptide (GALP) stimulates the release of gonadotropin-releasing hormone in rodent and primate species. The widespread distribution of GALP fibers in the hypothalamus suggests that this neuropeptide may influence hypophysiotropic factors that control other aspects of adenohypophysial function. Here we studi... |
16113589 | Statin monotherapy attenuates renal injury in a salt-sensitive hypertension model of renal disease. | Several salutary biological effects of statins have been described. We sought to investigate more closely the anti-inflammatory and antiproliferative effects of simvastatin (SIMV) in a model of hypertension and progressive renal disease, as well as its effects on the cyclin-cdk inhibitors p21 and p27. |
16113590 | Monoamine oxidase activity and tri-iodothyronine level in violent offenders with early behavioural problems. | The focus is on evaluating the relationships between early behavioural problems and biochemical variables at adult age and their significance for early criminality and violent behaviour in a life perspective. In the present study, using prospective longitudinal data, a sample of males with a history of early criminal b... |
16113575 | Preimplantation genetic diagnosis of Canavan disease. | Canavan disease is an autosomal recessive disorder which is mon in Ashkenazi Jews. It is characterized by developmental delay, severe hypotonia and early death, and is caused by a deficiency of aspartoacylase which is encoded by the ASPA gene. In Ashkenazi Jews, one major mutation (E285A) and one minor mutation (Y231X)... |
16113592 | Preoperative assessment of pancreatic tumors using magnetic resonance imaging, endoscopic ultrasonography, positron emission tomography and laparoscopy. | The appropriate preoperative evaluation of a pancreatic tumor remains a matter of debate. |
16113596 | In vivo evaluation of limonene-based transdermal therapeutic system of nicorandil in healthy human volunteers. | Hydroxypropyl methylcellulose (HPMC) gel drug reservoir system prepared with 70:30 v/v ethanol-water solvent system containing 6% w/w of limonene was effective in promoting the in vitro transdermal delivery of nicorandil. The objective of the present study was to fabricate and evaluate a limonene-based transdermal ther... |
16113597 | Deep subcutaneous application of poly-L-lactic acid as a filler for facial lipoatrophy in HIV-infected patients. | Facial lipoatrophy is a crucial problem of HIV-infected patients undergoing highly active antiretroviral therapy (HAART). Poly-L-lactic acid (PLA), provided as New-Fill/Sculptra, is known as one possible treatment option. In 2004 PLA was approved by the FDA as Sculptra for the treatment of lipoatrophy of the face in HI... |
16113595 | Sunscreens - which and what for? | It is well established that sun exposure is the main cause for the development of skin cancer. Chronic continuous UV radiation is believed to induce malignant melanoma, whereas intermittent high-dose UV exposure contributes to the occurrence of actinic keratosis as precursor lesions of squamous cell carcinoma as well a... |
16113599 | Transcutaneous immunization with cytotoxic T-cell peptide epitopes provides effective antitumor immunity in mice. | Much attention has been focused on transcutaneous immunization strategies to stimulate systemic cytotoxic T lymphocyte responses leading to anti-tumor or anti-microbial immunity. Here we report that topical application of vaccines consisting of synthetic peptides formulated with imiquimod, a Toll-like receptor agonist ... |
16113600 | Protection of NOD mice from type 1 diabetes after oral inoculation with vaccinia viruses expressing adjuvanted islet autoantigens. | Oral administration of autoantigens and allergens can delay or suppress clinical disease in experimental autoimmune and allergic disorders. However, repeated feeding of large amounts of the tolerogens is required over long periods and is only partially effective in animals systemically sensitized to the ingested antige... |
16113605 | Histologic predictors of renal cell carcinoma response to interleukin-2-based therapy. | The authors examined pathology from patients with renal cancer (RCC) treated with IL-2 to determine response rates for clear cell and variant RCC and to identify histologic features that predict response. Pathology specimens were reviewed by a single pathologist who was blinded to both the prior pathology interpretatio... |
16113615 | Pediatric bipolar disorder: a review of the past 10 years. | To review the literature of the past decade covering the epidemiology, clinical characteristics, assessment, longitudinal course, biological and psychosocial correlates, and treatment and prevention of pediatric bipolar disorder (BD). |
16113601 | Neuroblastoma cells transiently transfected to simultaneously express the co-stimulatory molecules CD54, CD80, CD86, and CD137L generate antitumor immunity in mice. | The goal of this study was to show that nonviral gene transfection technology can be used to genetically modify neuroblastoma cells with immune stimulatory molecules, and that the modified cells can generate an antitumor immune response. The authors found that an electroporation-based gene transfection method, nucleofe... |
16113602 | B-cell lymphoma and myeloma protection induced by idiotype vaccination with dendritic cells is mediated entirely by T cells in mice. | Immunoglobulin idiotypes (Id) of malignant B cells are tumor-specific antigens that may be targeted for immunotherapy. Id-directed immunotherapy by immunization with autologous Id has been initiated in clinical trials to control residual disease in B-cell lymphoma and multiple myeloma. The effector mechanisms responsib... |
16113616 | Family-based treatment research: a 10-year update. | To provide an update on the state of the art of family-based treatment research. |
16113617 | A randomized effectiveness trial of brief cognitive-behavioral therapy for depressed adolescents receiving antidepressant medication. | To test a collaborative-care, cognitive-behavioral therapy (CBT) program adjunctive to selective serotonin reuptake inhibitor (SSRI) treatment in HMO pediatric primary care. |
16113607 | Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. | Twenty-two HLA A*0201 patients with stage IV melanoma were enrolled in a phase 1 safety and feasibility trial using posite dendritic cell (DC) vaccine generated by culturing CD34 hematopoietic progenitors and activated with IFN-alpha. The DC vaccine was loaded with peptides derived from four melanoma tissue differentia... |
16113618 | Predictive validity in a prospective follow-up of PTSD in preschool children. | To examine the predictive validity of an alternative to the DSM-IV for diagnosing posttraumatic stress disorder (PTSD) in preschool children and prospectively explore the course of PTSD symptomatology. |
16113603 | Tumor vaccination by Salmonella typhimurium after transformation with a eukaryotic expression vector in mice: impact of a Salmonella typhimurium gene interfering with MHC class I presentation. | Transformed attenuated Salmonella typhimurium (ST) have been suggested as an efficient means of tumor vaccination. However, ST themselves might be immunosuppressive, and the question has arisen as to whether this impedes vaccination efficacy even if ST are transformed with a eukaryotic expression vector such that "tumo... |
16113604 | Th1-polarizing capacity of clinical-grade dendritic cells is triggered by Ribomunyl but is compromised by PGE2: the importance of maturation cocktails. | The maturation state of (monocyte-derived) dendritic cells (DCs) determines the type of T-cell response. Currently, several maturation cocktails are used in clinical trials, monly a cocktail of TNF-alpha, PGE2, IL-1beta, and IL-6. The authors studied DC phenotype and functional ability to stimulate TH1 responses after ... |
16113619 | The genetic and environmental contributions to oppositional defiant behavior: a multi-informant twin study. | To estimate the genetic and environmental contributions to oppositional defiant behavior (ODB) from mother, father, and teacher report using the Conners Revised Short Forms in a large twin sample. |
16113606 | Vaccination of advanced hepatocellular carcinoma patients with tumor lysate-pulsed dendritic cells: a clinical trial. | Hepatocellular carcinoma (HCC) is mon and rapidly progressing malignancy. Current treatment options for advanced HCC are limited. This clinical study of dendritic cell (DC)-based immunotherapy for HCC enrolled 31 patients with advanced HCC. DCs, propagated from peripheral blood monocytes, were pulsed with autologous tu... |
16113620 | Atomoxetine alone or combined with fluoxetine for treating ADHD with comorbid depressive or anxiety symptoms. | Symptoms of depression and anxiety orbid with attention-deficit/hyperactivity disorder (ADHD). The authors assessed the safety and effectiveness of atomoxetine pared bined atomoxetine/fluoxetine therapy in a population of children and adolescents with ADHD and concurrent symptoms of depression or anxiety. |
16113621 | Hormonal correlates of clozapine-induced weight gain in psychotic children: an exploratory study. | Weight gain is a serious side effect of atypical antipsychotics, especially in childhood. In this study, the authors examined six weight gain-related hormones in patients with childhood-onset schizophrenia (COS) after 6 weeks of clozapine treatment. |
16113622 | White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study. | To investigate abnormalities in the structural integrity of brain white matter as suggested by diffusion tensor imaging in adolescents with early-onset schizophrenia (onset of psychosis by age 18). |
16113628 | Implications of the cAMP signaling pathway in psychiatric disorders: a systematic review of the evidence. | The last decade has seen a shift in the theoretical framework addressing the pathophysiology of psychiatric disorders. During this period, research endeavors have been directed toward investigating the biochemical mechanisms involved in the transduction of information from the cell surface to the cell interior. The eme... |
16113629 | Depression and Huntington's disease: prevalence, clinical manifestations, etiology, and treatment. | In order to determine the extent to which plicates Huntington's disease (HD), we have analyzed the existing literature on depression in HD in order to report the prevalence, clinical manifestations, and treatment of HD depression. By means of MEDLINE literature searches and reviews of HD articles' bibliographies, we id... |
16113630 | Partial Kluver-Bucy syndrome: two cases. | Kluver-Bucy syndrome (KBS) is a rare neuropsychiatric disorder that may be characterized by visual agnosia, placidity, altered sexual activity, hypermetamorphosis, and hyperorality. Patients with KBS present with plex behavioral syndrome. KBS is usually associated with lesions of the amygdala or amygdaloid pathways. Ho... |
16113631 | An innovative approach to clinical communication in schizophrenia: the approaches to schizophrenia communication checklists. | Side effects from antipsychotic medications can have a profound effect on patients' lives and may adversely affect their willingness ply with treatment. Identification of side effects through munication between psychiatrists, other members of the healthcare team, and their patients might increase pliance. The Approache... |
16113632 | The syndrome of traumatic grief. | Traumatic grief is mon and debilitating syndrome whose clinical presentation is well recognized but whose diagnostic criteria have only recently been delineated. Though it shares features with major depressive disorder, adjustment disorder, and posttraumatic stress disorder, none of these subsume the criteria set for t... |
16113633 | Increased oxidative DNA damage, 8-hydroxydeoxy- guanosine, in human pterygium. | Chronic exposure to ultraviolet (UV) light is a widely accepted aetiological factor in the development of pterygium. UV radiation may induce production of reactive oxygen species via photosensitized oxidation, thus causing oxidative damage. This study was conducted to test the hypothesis that oxidative damage to DNA is... |
16113636 | Association of hospital and surgeon operation volume with the incidence of postoperative endophthalmitis: Taiwan experience. | To determine the association between hospital and surgeon volume with the incidence of postoperative endophthalmitis. |
16113645 | p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation. | Target-derived neurotrophins regulate neuronal survival and growth by interacting with cell-surface tyrosine kinase receptors. The p75 neurotrophin receptor (p75 NTR) is coexpressed with Trk receptors in long-range projection neurons, in which it facilitates neurotrophin binding to Trk and enhances Trk activity. Here, ... |
16113646 | Transcriptional activation by bidirectional RNA polymerase II elongation over a silent promoter. | Transcriptional interference denotes negative cis effects between promoters. Here, we show that promoters can also interact positively. Bidirectional RNA polymerase II (Pol II) elongation over the silent human endogenous retrovirus (HERV)-K 18 promoter (representative of 2.5 x 10(3) similar promoters genomewide) activa... |
16113647 | Bcr-Abl activates the AKT/Fox O3 signalling pathway to restrict transforming growth factor-beta-mediated cytostatic signals. | The fusion of Abl with either Bcr or Tel in human leukaemia leads to the constitutive activation of Abl tyrosine kinase, which in turn induces growth-factor-independent proliferation and cell survival. However, the mechanism by which Bcr-Abl induces cellular transformation has not yet been well characterized. Here, we ... |
16113648 | Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs. | During asymmetric cell division in Drosophila sensory organ precursors (SOPs), the Numb protein segregates into one of the two daughter cells, in which it inhibits Notch signalling to specify pIIb cell fate. We show here that Numb acts in SOP cells by inducing the endocytosis of Sanpodo, a four-pass transmembrane prote... |
16113650 | Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation. | Given that ligand binding is essential for the rapid internalization of epidermal growth factor receptor (EGFR), the events induced by ligand binding probably contribute to the regulation of EGFR internalization. These events include receptor dimerization, activation of intrinsic tyrosine kinase activity and autophosph... |
16113649 | The small chemical vacuolin-1 alters the morphology of lysosomes without inhibiting Ca2+-regulated exocytosis. | Ca2+-regulated exocytosis of lysosomes was previously shown to be required for the repair of plasma membrane wounds. The small chemical vacuolin-1 alters the morphology of lysosomes without affecting the ability of cells to reseal their plasma membrane after injury. On the basis of a failure to detect Ca2+-triggered ly... |
16113651 | Separate fusion of outer and inner mitochondrial membranes. | Mitochondria are enveloped by two closely apposed boundary membranes with different properties and functions. It is known that they undergo fusion and fission, but it has remained unclear whether outer and inner membranes fuse simultaneously, coordinately or separately. We set up assays for the study of inner and outer... |
16113652 | Plant and animal homeodomains use convergent mechanisms for intercellular transfer. | Homeoproteins are defined by the structure of their DNA-binding domain, the homeodomain. Intercellular transfer of homeoprotein was observed ex vivo between animal cells and in vivo in higher plants. In the latter case, transfer is through intercytoplasmic channels that connect plant cells, but these do not exist in an... |
16113653 | Ablation of the spindle assembly checkpoint by a compound targeting Mps1. | The spindle assembly checkpoint ensures accurate chromosome segregation by delaying anaphase initiation until all chromosomes are properly attached to the mitotic spindle. Here, we show that the previously reported c-Jun amino-terminal kinase (JNK) inhibitor SP600125 effectively disrupts spindle checkpoint function in ... |
16113654 | Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition. | The plex/cyclosome (APC/C) is a multisubunit E3 ligase required for ubiquitin-dependent proteolysis of cell-cycle-regulatory proteins, including mitotic cyclins and securin/Pds1. Regulation of APC/C activity and substrate recognition, mediated by the coactivators Cdc20 and Cdh1, is fundamental to cell-cycle control. Ho... |
16113656 | Anopheles gambiae SRPN2 facilitates midgut invasion by the malaria parasite Plasmodium berghei. | We report on a phylogenetic and functional analysis of genes encoding three mosquito serpins (SRPN1, SRPN2 and SRPN3), which resemble known inhibitors of prophenoloxidase-activating enzymes in other insects. Following RNA interference induction by double-stranded RNA injection, knockdown of SRPN2 in adult Anopheles gam... |
16113655 | tRNA-balanced expression of a eukaryal aminoacyl-tRNA synthetase by an mRNA-mediated pathway. | Aminoacylation of transfer RNAs is a key step during translation. It is catalysed by the aminoacyl-tRNA synthetases (aaRSs) and requires the specific recognition of their cognate substrates, one or several tRNAs, ATP and the amino acid. Whereas the control of certain aaRS genes is well known in prokaryotes, little is k... |
16113659 | Myeloablative allogeneic hematopoietic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia in adults: significant roles of total body irradiation and chronic graft-versus-host disease. | Disease-free survival in Philadelphia chromosome-positive ALL (Ph + ALL) is very poor, and allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently considered the only procedure with curative potential. To identify factors affecting transplant e, we analyzed the data from 197 Ph + ALL patients aged 1... |
16113660 | Impact of different strategies of second-line stem cell harvest on the outcome of autologous transplantation in poor peripheral blood stem cell mobilizers. | The optimal approach to obtain an adequate graft for transplantation in patients with poor peripheral blood stem cell (PBSC) mobilization remains unclear. We retrospectively assessed the impact of different strategies of second-line stem cell harvest on the transplantation e of patients who failed PBSC mobilization in ... |
16113661 | Cardiac complications after haploidentical HLA-mismatched hematopoietic stem cell transplantation using in vivo alemtuzumab. | Alemtuzumab is a humanized monoclonal antibody directed against human CD52 with a strong lympholytic effect. We have performed unmanipulated hematopoietic stem cell transplantation (HSCT) from 2- or 3-locus-mismatched family donors in 14 patients using in vivo alemtuzumab. All plete donor cell engraftment and grade III... |
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