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L-carnitine treatment of insulin resistance: A systematic review and meta-analysis Ying Xu 1 , Wenjie Jiang 2 , Guochang Chen 1 , Wenjiao Zhu 3 , Weiliang Ding 3 , Zhijun Ge 4 , Yongfei Tan 5 , Tieliang Ma 3 , Guoxing Cui 1 Affiliations Expand Affiliations 1 Department of Gastroenterology, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China. 2 Department of Anesthesiology, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China. 3 Central Laboratory, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China. 4 Department of Critical Care Medicine, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China. 5 Department of Cardiac & Thoracic Surgery, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China. PMID: 28791854 DOI: 10.17219/acem/61609 Free article Item in Clipboard Review L-carnitine treatment of insulin resistance: A systematic review and meta-analysis Ying Xu et al. Adv Clin Exp Med . 2017 Mar-Apr . Free article Show details Display options Display options Format Abstract PubMed PMID Adv Clin Exp Med Actions Search in PubMed Search in NLM Catalog Add to Search . 2017 Mar-Apr;26(2):333-338. doi: 10.17219/acem/61609. Authors Ying Xu 1 , Wenjie Jiang 2 , Guochang Chen 1 , Wenjiao Zhu 3 , Weiliang Ding 3 , Zhijun Ge 4 , Yongfei Tan 5 , Tieliang Ma 3 , Guoxing Cui 1 Affiliations 1 Department of Gastroenterology, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China. 2 Department of Anesthesiology, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China. 3 Central Laboratory, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China. 4 Department of Critical Care Medicine, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China. 5 Department of Cardiac & Thoracic Surgery, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China. PMID: 28791854 DOI: 10.17219/acem/61609 Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID Abstract Background: L-carnitine has been used for several years as an adjuvant therapy in oxidative stress, blood sugar, high-sensitivity C-reactive protein (CRP), anemia, etc. However, the efficacy of L-carnitine treating insulin resistance (IR) remains controversial. Homeostasis model assessment of Insulin Resistance (HOMA-IR) is widely used in the clinical evaluation of patients with IR. Objectives: A meta-analysis, including randomized controlled trials (RCTs), was performed to assess the effect of L-carnitine on HOMA-IR patients. Material and methods: The Cochrane Library, PubMed, and EMBASE databases were systematically searched to identify RCTs which evaluated the effects of L-carnitine on HOMA-IR patients. We screened relevant studies according to predefined inclusion and exclusion criteria. In the selected articles, we extracted the data: study design, sample size, age, L-carnitine dose and regimen, body mass index (BMI) of patients, mode of administration, study duration and study outcomes. Results: A total of 5 studies were included for the meta-analysis. The result showed L-carnitine was useful in the treatment of IR (WMD -0.724, CI -0.959 -0.488, p < 0.0001). Evaluation at 3, 6, 9, 12 months, the p-values were 0.875, 0.165, 0.031, 0, 007, respectively. Conclusions: L-carnitine was useful in treating patients with IR. L-carnitine can treat IR more effectively with prolonging the medication time. However, more RCTs with long-term L-carnitine treatment of IR are needed to confirm the viewpoint. Keywords: L-carnitine; insulin resistance; meta-analysis. PubMed Disclaimer Similar articles A meta-analysis of the effect of angiotensin receptor blockers and calcium channel blockers on blood pressure, glycemia and the HOMA-IR index in non-diabetic patients. Yang Y, Wei RB, Xing Y, Tang L, Zheng XY, Wang ZC, Gao YW, Li MX, Chen XM. Yang Y, et al. Metabolism. 2013 Dec;62(12):1858-66. doi: 10.1016/j.metabol.2013.08.008. Epub 2013 Sep 16. Metabolism. 2013. PMID: 24050270 Review. The effects of L-carnitine supplementation on glycemic control: a systematic review and meta-analysis of randomized controlled trials. Fathizadeh H, Milajerdi A, Reiner Ž, Kolahdooz F, Asemi Z. Fathizadeh H, et al. EXCLI J. 2019 Aug 19;18:631-643. doi: 10.17179/excli2019-1447. eCollection 2019. EXCLI J. 2019. PMID: 31611746 Free PMC article. The effects of L-carnitine supplementation on glycemic markers in adults: A systematic review and dose-response meta-analysis. Zamani M, Pahlavani N, Nikbaf-Shandiz M, Rasaei N, Ghaffarian-Ensaf R, Asbaghi O, Shiraseb F, Rastgoo S. Zamani M, et al. Front Nutr. 2023 Jan 10;9:1082097. doi: 10.3389/fnut.2022.1082097. eCollection 2022. Front Nutr. 2023. PMID: 36704801 Free PMC article. Effect of programmed exercise on insulin sensitivity in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. Bueno-Notivol J, Calvo-Latorre J, Alonso-Ventura V, Pasupuleti V, Hernandez AV, Pérez-López FR; Health Outcomes and Systematic Analyses (HOUSSAY) Project. Bueno-Notivol J, et al. Menopause. 2017 Dec;24(12):1404-1413. doi: 10.1097/GME.0000000000000936. Menopause. 2017. PMID: 28654627 Review. Caloric restriction and L-carnitine administration improves insulin sensitivity in patients with impaired glucose metabolism. Molfino A, Cascino A, Conte C, Ramaccini C, Rossi Fanelli F, Laviano A. Molfino A, et al. JPEN J Parenter Enteral Nutr. 2010 May-Jun;34(3):295-9. doi: 10.1177/0148607109353440. JPEN J Parenter Enteral Nutr. 2010. PMID: 20467011 Clinical Trial. See all similar articles Cited by High-throughput metabolomics identifies new biomarkers for cervical cancer. Li X, Zhang L, Huang X, Peng Q, Zhang S, Tang J, Wang J, Gui D, Zeng F. Li X, et al. Discov Oncol. 2024 Mar 29;15(1):90. doi: 10.1007/s12672-024-00948-8. Discov Oncol. 2024. PMID: 38551775 Free PMC article. Acetyllevocarnitine Hydrochloride for the Treatment of Diabetic Peripheral Neuropathy: A Phase 3 Randomized Clinical Trial in China. Guo L, Pan Q, Cheng Z, Li Z, Jiang H, Zhang F, Li Y, Qiu W, Lu S, Tian J, Fu Y, Li F, Li D. Guo L, et al. Diabetes. 2024 May 1;73(5):797-805. doi: 10.2337/db23-0377. Diabetes. 2024. PMID: 38320260 Free PMC article. Clinical Trial. Combined Exercise Training and Nutritional Interventions or Pharmacological Treatments to Improve Exercise Capacity and Body Composition in Chronic Obstructive Pulmonary Disease: A Narrative Review. Brauwers B, Machado FVC, Beijers RJHCG, Spruit MA, Franssen FME. Brauwers B, et al. Nutrients. 2023 Dec 18;15(24):5136. doi: 10.3390/nu15245136. Nutrients. 2023. PMID: 38140395 Free PMC article. Review. Ameliorating effects of L-carnitine and synbiotic co-supplementation on anthropometric measures and cardiometabolic traits in women with obesity: a randomized controlled clinical trial. Fallah F, Mahdavi R. Fallah F, et al. Front Endocrinol (Lausanne). 2023 Oct 18;14:1237882. doi: 10.3389/fendo.2023.1237882. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37929031 Free PMC article. Clinical Trial. Assessing the In Vitro and In Vivo Performance of L-Carnitine-Loaded Nanoparticles in Combating Obesity. Uner B, Ergin AD, Ansari IA, Macit-Celebi MS, Ansari SA, Kahtani HMA. Uner B, et al. Molecules. 2023 Oct 16;28(20):7115. doi: 10.3390/molecules28207115. Molecules. 2023. PMID: 37894594 Free PMC article. 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