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Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers J B Whitfield 1 , G Zhu , A C Heath , L W Powell , N G Martin Affiliations Expand Affiliation 1 Department of Clinical Biochemistry, Royal Prince Alfred Hospital, and University of Sydney, Sydney, Australia. johnwit@bioc.rpa.cs.nsw.gov.au PMID: 11505030 Item in Clipboard Clinical Trial Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers J B Whitfield et al. Alcohol Clin Exp Res . 2001 Jul . Show details Display options Display options Format Abstract PubMed PMID Alcohol Clin Exp Res Actions Search in PubMed Search in NLM Catalog Add to Search . 2001 Jul;25(7):1037-45. Authors J B Whitfield 1 , G Zhu , A C Heath , L W Powell , N G Martin Affiliation 1 Department of Clinical Biochemistry, Royal Prince Alfred Hospital, and University of Sydney, Sydney, Australia. johnwit@bioc.rpa.cs.nsw.gov.au PMID: 11505030 Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID Abstract Background: Alcohol increases body iron stores. Alcohol and iron may increase oxidative stress and the risk of alcohol-related liver disease. The relationship between low or "safe" levels of alcohol use and indices of body iron stores, and the factors that affect the alcohol-iron relationship, have not been fully characterized. Other aspects of the biological response to alcohol use have been reported to depend on iron status. Methods: We have measured serum iron, transferrin, and ferritin as indices of iron stores in 3375 adult twin subjects recruited through the Australian Twin Registry. Information on alcohol use and dependence and smoking was obtained from questionnaires and interviews. Results: Serum iron and ferritin increased progressively across classes of alcohol intake. The effects of beer consumption were greater than those of wine or spirits. Ferritin concentration was significantly higher in subjects who had ever been alcohol dependent. There was no evidence of interactions between HFE genotype or body mass index and alcohol. Alcohol intake-adjusted carbohydrate-deficient transferrin was increased in women in the lowest quartile of ferritin results, whereas adjusted gamma-glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase values were increased in subjects with high ferritin. Conclusions: Alcohol intake at low level increases ferritin and, by inference, body iron stores. This may be either beneficial or harmful, depending on circumstances. The response of biological markers of alcohol intake can be affected by body iron stores; this has implications for test sensitivity and specificity and for variation in biological responses to alcohol use. PubMed Disclaimer Similar articles Effect of type of alcoholic beverages on carbohydrate-deficient transferrin, sialic acid, and liver enzymes. Sillanaukee P, van der Gaag MS, Sierksma A, Hendriks HF, Strid N, Pönniö M, Nikkari ST. Sillanaukee P, et al. Alcohol Clin Exp Res. 2003 Jan;27(1):57-60. doi: 10.1097/01.ALC.0000047302.67780.FA. Alcohol Clin Exp Res. 2003. PMID: 12544006 [Effect of body iron stores in the indicators of alcohol abuse and alcoholic liver injury]. Cylwik B, Daniluk M, Chrostek L, Szmitkowski M. Cylwik B, et al. Pol Merkur Lekarski. 2010 Jun;28(168):450-3. Pol Merkur Lekarski. 2010. PMID: 20642102 Polish. CDT, GGT, and AST as markers of alcohol use: the WHO/ISBRA collaborative project. Conigrave KM, Degenhardt LJ, Whitfield JB, Saunders JB, Helander A, Tabakoff B; WHO/ISBRA Study Group. Conigrave KM, et al. Alcohol Clin Exp Res. 2002 Mar;26(3):332-9. Alcohol Clin Exp Res. 2002. PMID: 11923585 [Diagnostic tests of alcohol consumption]. Chrostek L, Szmitkowski M. Chrostek L, et al. Pol Merkur Lekarski. 2002 Aug;13(74):154-7. Pol Merkur Lekarski. 2002. PMID: 12420351 Review. Polish. [The effect of alcohol on iron metabolism]. Cylwik B, Chrostek L, Szmitkowski M. Cylwik B, et al. Pol Merkur Lekarski. 2008 Jun;24(144):561-4. Pol Merkur Lekarski. 2008. PMID: 18702344 Review. Polish. See all similar articles Cited by The influence of iron on bone metabolism disorders. Zhang H, Yang F, Cao Z, Xu Y, Wang M. Zhang H, et al. Osteoporos Int. 2024 Feb;35(2):243-253. doi: 10.1007/s00198-023-06937-x. Epub 2023 Oct 19. Osteoporos Int. 2024. PMID: 37857915 Review. Sex difference in the association between blood alcohol concentration and serum ferritin. Yehia A, Sousa RAL, Abulseoud OA. Yehia A, et al. Front Psychiatry. 2023 Jul 21;14:1230406. doi: 10.3389/fpsyt.2023.1230406. eCollection 2023. Front Psychiatry. 2023. PMID: 37547205 Free PMC article. Association between iron accumulation in the dorsal striatum and compulsive drinking in alcohol use disorder. Tan H, Hubertus S, Thomas S, Lee AM, Gerhardt S, Gerchen MF, Sommer WH, Kiefer F, Schad L, Vollstädt-Klein S. Tan H, et al. Psychopharmacology (Berl). 2023 Feb;240(2):249-257. doi: 10.1007/s00213-022-06301-7. Epub 2022 Dec 29. Psychopharmacology (Berl). 2023. PMID: 36577866 Free PMC article. Dietary Iron Intake and Biomarkers of Iron Status in Slovenian Population: Results of SI.Menu/Nutrihealth Study. Lavriša Ž, Hristov H, Hribar M, Koroušić Seljak B, Gregorič M, Blaznik U, Zaletel K, Oblak A, Osredkar J, Kušar A, Žmitek K, Lainščak M, Pravst I. Lavriša Ž, et al. Nutrients. 2022 Dec 3;14(23):5144. doi: 10.3390/nu14235144. Nutrients. 2022. PMID: 36501175 Free PMC article. Lifestyle and dietary factors, iron status and one-carbon metabolism polymorphisms in a sample of Italian women and men attending a Transfusion Medicine Unit: a cross-sectional study. Bortolus R, Filippini F, Chiaffarino F, Udali S, Rinaldi M, Gandini G, Montagnana M, Lippi G, Olivieri O, Parazzini F, Friso S. Bortolus R, et al. Br J Nutr. 2023 Jul 14;130(1):65-70. doi: 10.1017/S0007114522003245. Epub 2022 Oct 28. Br J Nutr. 2023. PMID: 36305043 Free PMC article. See all "Cited by" articles Publication types Clinical Trial Actions Search in PubMed Search in MeSH Add to Search Research Support, Non-U.S. Gov't Actions Search in PubMed Search in MeSH Add to Search Research Support, U.S. Gov't, P.H.S. 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