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Epub 2010 Apr 13. Short term effects of reduced exposure to cigarette smoke on white blood cells, platelets and red blood cells in adult cigarette smokers Hans J Roethig 1 , Tamara Koval , Raheema Muhammad-Kah , Yan Jin , Paul Mendes , Martin Unverdorben Affiliations Expand Affiliation 1 Altria Client Services, Richmond, VA 23219, USA. PMID: 20394790 DOI: 10.1016/j.yrtph.2010.04.005 Item in Clipboard Randomized Controlled Trial Short term effects of reduced exposure to cigarette smoke on white blood cells, platelets and red blood cells in adult cigarette smokers Hans J Roethig et al. Regul Toxicol Pharmacol . 2010 Jul-Aug . Show details Display options Display options Format Abstract PubMed PMID Regul Toxicol Pharmacol Actions Search in PubMed Search in NLM Catalog Add to Search . 2010 Jul-Aug;57(2-3):333-7. doi: 10.1016/j.yrtph.2010.04.005. Epub 2010 Apr 13. Authors Hans J Roethig 1 , Tamara Koval , Raheema Muhammad-Kah , Yan Jin , Paul Mendes , Martin Unverdorben Affiliation 1 Altria Client Services, Richmond, VA 23219, USA. PMID: 20394790 DOI: 10.1016/j.yrtph.2010.04.005 Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID Abstract Previous studies indicate that cigarette smokers have a 5-30% higher white blood cell counts (WBC) compared to non-smokers and higher red blood cell counts. Methods: This study was to pool hematology data from three similar studies and analyze the data for effects on WBC, its subpopulations, platelets, red blood cell count (RBC) and hematocrit in adult cigarette smokers three days after using an electrically heated cigarette smoking system (EHCSS) as a potential reduced exposure product (PREP) or no-smoking compared to smoking a conventional cigarette. Results: Lower exposure to cigarette smoke in adult, long term smokers, by using an EHCSS or stopping smoking, leads to statistically significant decreases of up to 9% in WBC, neutrophils, lymphocytes, platelets, RBC and hematocrit within three days. Switching from CC-smoking to EHCSS-smoking or no-smoking resulted in lower WBC and vice versa within 3 days. Conclusion: This clinical model may be used as a screening tool to find new technologies that could provide insights on changes in inflammation resulting from the change in cigarette smoke. Copyright 2010 Elsevier Inc. All rights reserved. PubMed Disclaimer Similar articles Acute effects of cigarette smoking on pulmonary function. Unverdorben M, Mostert A, Munjal S, van der Bijl A, Potgieter L, Venter C, Liang Q, Meyer B, Roethig HJ. Unverdorben M, et al. Regul Toxicol Pharmacol. 2010 Jul-Aug;57(2-3):241-6. doi: 10.1016/j.yrtph.2009.12.013. Epub 2010 Mar 15. Regul Toxicol Pharmacol. 2010. PMID: 20233598 Clinical Trial. Effects of different levels of cigarette smoke exposure on prognostic heart rate and rate--pressure-product parameters. Unverdorben M, van der Bijl A, Potgieter L, Venter C, Munjal S, Qiwei Liang, Meyer B, Röthig HJ. Unverdorben M, et al. J Cardiovasc Pharmacol Ther. 2008 Sep;13(3):175-82. doi: 10.1177/1074248408321571. Epub 2008 Jul 15. J Cardiovasc Pharmacol Ther. 2008. PMID: 18628485 Clinical Trial. Short-term exposure evaluation of adult smokers switching from conventional to first-generation electrically heated cigarettes during controlled smoking. Roethig HJ, Kinser RD, Lau RW, Walk RA, Wang N. Roethig HJ, et al. J Clin Pharmacol. 2005 Feb;45(2):133-45. doi: 10.1177/0091270004271253. J Clin Pharmacol. 2005. PMID: 15647405 Clinical Trial. [Smoking reduction and temporary abstinence: new approaches for smoking cessation]. Le Houezec J, Säwe U. Le Houezec J, et al. J Mal Vasc. 2003 Dec;28(5):293-300. J Mal Vasc. 2003. PMID: 14978435 Review. French. Effects of cigarette smoke and nicotine on platelets and experimental coronary artery thrombosis. Folts JD, Gering SA, Laibly SW, Bertha BG, Bonebrake FC, Keller JW. Folts JD, et al. Adv Exp Med Biol. 1990;273:339-58. doi: 10.1007/978-1-4684-5829-9_33. Adv Exp Med Biol. 1990. PMID: 2288288 Review. See all similar articles Cited by Impacts of cigarette smoking on blood circulation: do we need a new approach to blood donor selection? Wang J, Wang Y, Zhou W, Huang Y, Yang J. Wang J, et al. J Health Popul Nutr. 2023 Jul 5;42(1):62. doi: 10.1186/s41043-023-00405-2. J Health Popul Nutr. 2023. PMID: 37408051 Free PMC article. Review. Biomarkers of Exposure and Potential Harm in Two Weeks of Smoking Abstinence: Changes in Biomarkers of Platelet Function, Oxidative Stress, and Inflammation. Makena P, Scott E, Chen P, Liu HP, Jones BA, Prasad GL. Makena P, et al. Int J Mol Sci. 2023 Mar 27;24(7):6286. doi: 10.3390/ijms24076286. Int J Mol Sci. 2023. PMID: 37047257 Free PMC article. Clearing the Haze: How Does Nicotine Affect Hematopoiesis before and after Birth? Cool T, Baena ARY, Forsberg EC. Cool T, et al. Cancers (Basel). 2021 Dec 30;14(1):184. doi: 10.3390/cancers14010184. Cancers (Basel). 2021. PMID: 35008347 Free PMC article. Review. Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation. Darabseh MZ, Maden-Wilkinson TM, Welbourne G, Wüst RCI, Ahmed N, Aushah H, Selfe J, Morse CI, Degens H. Darabseh MZ, et al. Sci Rep. 2021 Jun 10;11(1):12286. doi: 10.1038/s41598-021-91510-x. Sci Rep. 2021. PMID: 34112815 Free PMC article. Elevated Neutrophil to Lymphocyte Ratio in Older Adults with Cocaine Use Disorder as a Marker of Chronic Inflammation. Soder HE, Berumen AM, Gomez KE, Green CE, Suchting R, Wardle MC, Vincent J, Teixeira AL, Schmitz JM, Lane SD. Soder HE, et al. Clin Psychopharmacol Neurosci. 2020 Feb 29;18(1):32-40. doi: 10.9758/cpn.2020.18.1.32. Clin Psychopharmacol Neurosci. 2020. 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