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CITATION.cff

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+cff-version: 1.2.0
+title: "SpliceAI MANE Select v1.5 GRCh38 SNV scores (D=500, masked)"
+message: "Please cite this dataset, the generation software, the original SpliceAI publication, and MANE."
+type: dataset
+authors:
+  - family-names: Luo
+    given-names: Yiming
+version: 1.0.0
+date-released: 2026-10-03
+license: CC-BY-NC-4.0
+repository-code: "https://github.com/yimingluo-md/batched-inference-for-spliceai"
+references:
+  - type: software
+    title: "Batched inference for SpliceAI"
+    authors:
+      - family-names: Luo
+        given-names: Yiming
+    version: 0.1.0rc4
+    repository-code: "https://github.com/yimingluo-md/batched-inference-for-spliceai"
+  - type: article
+    title: "Predicting Splicing from Primary Sequence with Deep Learning"
+    authors:
+      - family-names: Jaganathan
+        given-names: Kishore
+    year: 2019
+    journal: Cell
+    doi: 10.1016/j.cell.2018.12.015
+  - type: article
+    title: "A joint NCBI and EMBL-EBI transcript set for clinical genomics and research"
+    authors:
+      - family-names: Morales
+        given-names: Joannella
+    year: 2022
+    journal: Nature
+    doi: 10.1038/s41586-022-04558-8

LICENSE.md

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+# Creative Commons Attribution-NonCommercial 4.0 International
+
+This dataset is licensed under the Creative Commons Attribution-NonCommercial
+4.0 International license (CC BY-NC 4.0).
+
+You are free to share and adapt the material under the following terms:
+
+- **Attribution:** Give appropriate credit, provide a link to the license, and
+  indicate whether changes were made. Do not imply endorsement.
+- **NonCommercial:** You may not use the material for commercial purposes.
+- **No additional restrictions:** You may not apply legal or technological
+  measures that legally restrict others from doing anything the license permits.
+
+The complete, controlling legal code is available at:
+
+<https://creativecommons.org/licenses/by-nc/4.0/legalcode>
+
+The license applies to the dataset and generated score files to the extent they
+are licensable by the dataset publisher. SpliceAI, its trained models, MANE,
+GRCh38, third-party software, names, and trademarks retain their respective
+rights and terms. No rights beyond those held by the dataset publisher are
+granted.

NOTICE.md

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+# Notices and attribution
+
+## SpliceAI
+
+The scores were produced using SpliceAI 1.3.1 and its five-model ensemble.
+SpliceAI was developed by Illumina, Inc. This dataset is independent and is not
+affiliated with or endorsed by Illumina. The SpliceAI name is used only to
+identify compatibility with the upstream method and score format.
+
+Please cite:
+
+Jaganathan K, et al. Predicting Splicing from Primary Sequence with Deep
+Learning. *Cell*. 2019;176(3):535–548.e24.
+<https://doi.org/10.1016/j.cell.2018.12.015>
+
+## MANE
+
+Transcript definitions are derived from MANE Select v1.5. The source MANE
+annotation itself is not redistributed in this dataset.
+
+Please cite:
+
+Morales J, et al. A joint NCBI and EMBL-EBI transcript set for clinical
+genomics and research. *Nature*. 2022;604:310–315.
+<https://doi.org/10.1038/s41586-022-04558-8>
+
+## Reference genome
+
+Scores use GRCh38/hg38 coordinates. Reference genome sequence is not included.
+
+## Generation software
+
+The generation software is available separately under GPL-3.0-or-later:
+
+<https://github.com/yimingluo-md/batched-inference-for-spliceai>
+
+The dataset license does not alter the software license, and the software
+license does not replace the dataset license.
+
+## External validation
+
+The Broad SpliceAI Lookup service was used as an external scientific
+comparator. Raw API responses are not included. Broad Institute does not
+endorse this dataset.
+
+## Research-use notice
+
+This dataset is not a validated clinical diagnostic device. Predictions require
+independent review and must not be the sole basis for patient-care decisions.

README.md

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 ---
+pretty_name: "SpliceAI MANE Select v1.5 GRCh38 SNV scores (D=500, masked)"
 license: cc-by-nc-4.0
+language:
+- en
+tags:
+- biology
+- genomics
+- bioinformatics
+- variants
+- vcf
+- spliceai
+- grch38
+- mane-select
+size_categories:
+- 1B<n<10B
 ---
+
+# SpliceAI MANE Select v1.5 GRCh38 SNV scores
+
+Masked SpliceAI 1.3.1 scores for all three possible non-reference single-
+nucleotide variants at every A/C/G/T position within the union of MANE Select
+v1.5 transcript spans on the 24 GRCh38 primary chromosomes.
+
+The predictions were computed with a maximum distance of 500 nucleotides
+(`D=500`) and masking enabled (`M=1`). The release contains **3,408,398,835
+SNV records** in 24 bgzip-compressed, tabix-indexed VCF files. The compressed
+VCFs total 34.32 GB (31.96 GiB).
+
+This is an independent research dataset. It is not affiliated with or endorsed
+by Illumina. “SpliceAI” is used descriptively to identify compatibility with
+the SpliceAI score format.
+
+## Why this dataset was generated
+
+The original GRCh38 precomputed SpliceAI scores used an older transcript set
+and genome-build liftover. Martin-Geary et al. reported transcript-selection
+and liftover-related discrepancies in that resource
+([doi:10.1101/2025.08.27.25334471](https://doi.org/10.1101/2025.08.27.25334471)).
+The Broad SpliceAI Lookup service provides updated calculations but is designed
+for small, rate-limited queries rather than genome-wide annotation. Ensembl
+provides MANE-based SNV scores with a smaller reported distance. This dataset
+provides a bulk, reproducible MANE Select v1.5 resource with `D=500` and
+`M=1`. A wider search distance permits SpliceAI to report predicted splice-site
+changes farther from the queried variant; see Pitsava et al.
+([doi:10.1016/j.gim.2025.101574](https://doi.org/10.1016/j.gim.2025.101574)).
+
+## Dataset contents
+
+```text
+data/
+  spliceai-mane-v1.5-d500-m1.snv.chr1.vcf.gz
+  spliceai-mane-v1.5-d500-m1.snv.chr1.vcf.gz.tbi
+  ...
+  spliceai-mane-v1.5-d500-m1.snv.chrY.vcf.gz
+  spliceai-mane-v1.5-d500-m1.snv.chrY.vcf.gz.tbi
+metadata/
+  release-manifest.json
+  broad-validation-summary.json
+README.md
+USAGE.md
+LICENSE.md
+NOTICE.md
+CITATION.cff
+SHA256SUMS
+```
+
+Each VCF record has one alternate allele and a `SpliceAI` INFO value:
+
+```text
+ALLELE|SYMBOL|DS_AG|DS_AL|DS_DG|DS_DL|DP_AG|DP_AL|DP_DG|DP_DL
+```
+
+`DS` fields are delta scores for acceptor gain, acceptor loss, donor gain, and
+donor loss. `DP` fields are the corresponding signed positions relative to the
+variant. Scores are stored to two decimal places. A delta position associated
+with a displayed score of `0.00` should not be interpreted as evidence of an
+effect.
+
+No score threshold was applied. Users can select thresholds appropriate to
+their intended research application.
+
+## Genome and transcript scope
+
+- Genome assembly: GRCh38/hg38
+- Contigs: `1`–`22`, `X`, and `Y`
+- Transcript set: MANE Select v1.5
+- Primary-assembly MANE Select transcripts: 19,299
+- Variant class: SNVs only
+- Search distance: 500 nucleotides
+- Masking: enabled (`M=1`)
+- SpliceAI version: 1.3.1, five-model ensemble
+
+The release excludes 64 MANE Select v1.5 transcripts located only on GRCh38
+patch or alternate sequences. It does not contain MANE Plus Clinical-only
+transcripts, indels, mitochondrial variants, alternate loci, or patches.
+
+## Validation
+
+The completed production release was audited across all 3,419 source shards:
+
+- expected and observed records: 3,408,398,835;
+- missing SpliceAI annotations: 0;
+- all 24 primary chromosomes present;
+- all chromosome VCFs passed BGZF, tabix, count, and checksum checks;
+- deterministic production validation against the official SpliceAI 1.3.1
+  implementation passed;
+- 120 chromosome-balanced production SNVs were compared with the Broad
+  SpliceAI Lookup API at GRCh38, `D=500`, and `M=1`;
+- comparisons performed: 120/120;
+- matching MANE Select responses: 120/120;
+- delta-position differences: 0;
+- maximum absolute score difference: 0.005.
+
+The Broad service reports three decimal places while this VCF stores two, so a
+maximum difference of 0.005 is consistent with two-decimal quantization.
+
+Checksums and the machine-readable release manifest are included. The public
+VCF headers and manifests contain no execution-host paths.
+
+## Usage
+
+See [USAGE.md](USAGE.md) for download, checksum verification, tabix lookup,
+VCF annotation, chromosome naming, and interpretation examples.
+
+## Limitations and responsible use
+
+SpliceAI scores are computational predictions, not measurements of RNA
+splicing and not classifications of pathogenicity. They should be considered
+with transcript relevance, phenotype, population frequency, other evidence,
+and—when appropriate—RNA or other functional studies.
+
+This dataset is research material, not a validated clinical diagnostic device.
+It must not be the sole basis for diagnosis, treatment, or other patient-care
+decisions. Users are responsible for validation appropriate to their setting
+and for compliance with applicable professional, institutional, and regulatory
+requirements.
+
+Because this resource is limited to MANE Select transcripts, clinically
+important effects on alternative transcripts may be absent. Masking suppresses
+some predictions that coincide with annotated splice gains or unannotated
+splice losses. GRCh38 coordinates must not be used directly with another
+assembly.
+
+## License
+
+The dataset is distributed under the
+[Creative Commons Attribution-NonCommercial 4.0 International license](LICENSE.md)
+(CC BY-NC 4.0). Commercial use is not permitted under this license.
+
+The source software used to produce the data has separate GPL-3.0-or-later
+terms. The SpliceAI trained models and upstream materials retain their own
+terms and attribution. No model files, reference genome sequence, MANE source
+annotation, patient data, or Broad API response cache is included here.
+
+## Citation
+
+Please cite this dataset, the generation software, and the original SpliceAI
+publication:
+
+- Luo Y. *SpliceAI MANE Select v1.5 GRCh38 SNV scores (D=500, masked).* Dataset,
+  version 1.0.0, 2026.
+- Luo Y. *Batched inference for SpliceAI.* Version 0.1.0rc4.
+  <https://github.com/yimingluo-md/batched-inference-for-spliceai>
+- Jaganathan K, et al. Predicting Splicing from Primary Sequence with Deep
+  Learning. *Cell*. 2019;176(3):535–548.e24.
+  [doi:10.1016/j.cell.2018.12.015](https://doi.org/10.1016/j.cell.2018.12.015)
+- Morales J, et al. A joint NCBI and EMBL-EBI transcript set for clinical
+  genomics and research. *Nature*. 2022;604:310–315.
+  [doi:10.1038/s41586-022-04558-8](https://doi.org/10.1038/s41586-022-04558-8)
+
+## Reproducibility
+
+Generation software:
+<https://github.com/yimingluo-md/batched-inference-for-spliceai>
+
+Production source revision:
+[`a145b3c6aeee8fe020033a8a6a0e71816772e73a`](https://github.com/yimingluo-md/batched-inference-for-spliceai/commit/a145b3c6aeee8fe020033a8a6a0e71816772e73a)
+
+The public manifest records the reference, MANE annotation, runner, container,
+and source-code SHA-256 identifiers used for production.
+
+## AI-assisted development disclosure
+
+The generation software and release preparation were developed with assistance
+from OpenAI Codex (GPT-5.6 Sol) and Anthropic Claude Code (Claude Opus 5).
+AI-generated suggestions were reviewed and tested before inclusion. These tools
+are not project authors, and their use does not imply endorsement by OpenAI or
+Anthropic.

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+49d652fd8996bdbe6428329154986e1f8bfbefd39552281d2f91441183acf9d2  metadata/chromosomes/chr17.json
+32bc72a102f5fd3049da80aeb8c9878c0bc51dcbbbccd5558ca522d67e29e0aa  metadata/chromosomes/chr18.json
+2a85b325a39a90b39a21930f4e1507790396d5831a7bcc2cb9fba5a960aa4e51  metadata/chromosomes/chr19.json
+abd41bd84303e833cb4e1c3a80257dc8fa81a8305707784d1741a6da4a8bcb76  metadata/chromosomes/chr2.json
+dfb8fd1dff8888775e86110d8c58a3de86e3bf40fc6cb4e1365ad1aa03419601  metadata/chromosomes/chr20.json
+3d6d9f3d41f8aff231a2bec1b459ba6b9b881f94eb64024ad1061971e9e3e2a6  metadata/chromosomes/chr21.json
+76f1662c123ffee3ab852d5ca3695c3b6ce87de586541e5e9f2c41e1509095d3  metadata/chromosomes/chr22.json
+f871e75af8f4fc406deb3461992dd0d7a5f68101adcce699e967975fad6eb5a6  metadata/chromosomes/chr3.json
+fccc388db834899badb0c2029e6abe12c77864c0bb8e9be64b77ad19bb37e550  metadata/chromosomes/chr4.json
+33e3d5bb304bec183ec027d35ca8ebe65453e8519f9c404808aa31169a3948b6  metadata/chromosomes/chr5.json
+b3acd6074cbced79cbaea65715889368152c061abbe2aca1672131fb147c1066  metadata/chromosomes/chr6.json
+5c2d5f0712a285337c8509ee4670459f0d03a016fb010f01af243707d2c500d7  metadata/chromosomes/chr7.json
+d004d38bf9090855eb16086975086509529a2d0b80806f92be00ad88aa40129d  metadata/chromosomes/chr8.json
+a51234c29d7e9caa75d677ee639c60ba14b0d1823e0fbbc276ad2b0f3645afdb  metadata/chromosomes/chr9.json
+33cc5ce21b2fb961f3b156d296fc5bc87c9d97e6f518835ededc110b62da8492  metadata/chromosomes/chrX.json
+7ed9dfd511dbed884adfe3d015ed6e314b3d270c0ec6189656a8569d431866d1  metadata/chromosomes/chrY.json
+a994415f75ddd59fc37f31fd87697c1f5af45b7e12283a17bd2c1699909a0b27  metadata/release-manifest.json

UPLOAD_READY.json

@@ -0,0 +1,11 @@
+{
+  "status": "passed",
+  "dataset_version": "1.0.0",
+  "records": 3408398835,
+  "chromosomes": 24,
+  "license": "CC-BY-NC-4.0",
+  "metadata_sanitized": true,
+  "records_byte_identical_to_audited_source": true,
+  "release_manifest_sha256": "a994415f75ddd59fc37f31fd87697c1f5af45b7e12283a17bd2c1699909a0b27",
+  "finalized_at": "2026-10-03T20:18:00.511235+00:00"
+}

USAGE.md

@@ -0,0 +1,117 @@
+# Usage
+
+## Download
+
+Install the Hugging Face command-line client and download the dataset:
+
+```bash
+python -m pip install --upgrade "huggingface_hub[hf_xet]"
+hf download luoyiming1991/spliceai-mane-v1.5-d500-m1-snv --repo-type dataset --local-dir spliceai-mane-v1.5-d500-m1-snv
+```
+
+To download only one chromosome, add the corresponding include patterns:
+
+```bash
+hf download luoyiming1991/spliceai-mane-v1.5-d500-m1-snv \
+  --repo-type dataset \
+  --include "data/*chr21.vcf.gz" "data/*chr21.vcf.gz.tbi" \
+  --local-dir spliceai-mane-v1.5-d500-m1-snv
+```
+
+## Verify the release
+
+Run checksum verification from the repository root:
+
+```bash
+sha256sum -c SHA256SUMS
+```
+
+On macOS, use:
+
+```bash
+shasum -a 256 -c SHA256SUMS
+```
+
+## Query a region
+
+The VCFs use contig names `1`–`22`, `X`, and `Y`, without a `chr` prefix.
+
+```bash
+bcftools view \
+  --regions 21:31705473-31705473 \
+  data/spliceai-mane-v1.5-d500-m1.snv.chr21.vcf.gz
+```
+
+Query selected INFO fields:
+
+```bash
+bcftools query \
+  --regions 21:31705473-31705473 \
+  --format '%CHROM\t%POS\t%REF\t%ALT\t%INFO/SpliceAI\n' \
+  data/spliceai-mane-v1.5-d500-m1.snv.chr21.vcf.gz
+```
+
+## Annotate an existing SNV VCF
+
+Normalize and split multiallelic records before annotation. The input must use
+GRCh38 coordinates and contig names compatible with the annotation VCF.
+
+```bash
+bcftools norm \
+  --fasta-ref GRCh38.fa \
+  --multiallelics -any \
+  input.vcf.gz \
+  --output-type z \
+  --output normalized.vcf.gz
+
+tabix --preset vcf normalized.vcf.gz
+
+bcftools annotate \
+  --annotations data/spliceai-mane-v1.5-d500-m1.snv.chr21.vcf.gz \
+  --columns INFO/SpliceAI \
+  --output-type z \
+  --output annotated.chr21.vcf.gz \
+  normalized.chr21.vcf.gz
+
+tabix --preset vcf annotated.chr21.vcf.gz
+```
+
+For a genome-wide input, split by chromosome and use the corresponding
+annotation file, then concatenate the annotated outputs in reference contig
+order. The separate VEP integration project will provide a pinned VEP plugin
+and workflow; it is not part of this dataset release.
+
+## SpliceAI field interpretation
+
+```text
+ALLELE|SYMBOL|DS_AG|DS_AL|DS_DG|DS_DL|DP_AG|DP_AL|DP_DG|DP_DL
+```
+
+- `DS_AG`: acceptor-gain delta score
+- `DS_AL`: acceptor-loss delta score
+- `DS_DG`: donor-gain delta score
+- `DS_DL`: donor-loss delta score
+- `DP_AG`, `DP_AL`, `DP_DG`, `DP_DL`: signed positions relative to the variant
+
+Scores range from 0 to 1 and are stored to two decimal places. No cutoff is
+applied in the dataset. Delta positions should be interpreted together with
+their corresponding scores, especially when the displayed score is `0.00`.
+
+`M=1` means predictions corresponding to annotated splice-site gains and
+unannotated splice-site losses are masked following SpliceAI semantics.
+`D=500` means the reported maximum score and position were selected within a
+500-nucleotide search distance on either side of the variant.
+
+## Programmatic access with pysam
+
+```python
+import pysam
+
+path = "data/spliceai-mane-v1.5-d500-m1.snv.chr21.vcf.gz"
+with pysam.VariantFile(path) as variants:
+    for record in variants.fetch("21", 31_705_472, 31_705_473):
+        print(record.chrom, record.pos, record.ref, record.alts, record.info["SpliceAI"])
+```
+
+The `pysam.fetch` interval is zero-based, half-open, while `record.pos` is
+one-based as specified by VCF.

metadata/broad-validation-summary.json

@@ -0,0 +1,47 @@
+{
+  "validation_date": "2026-10-03",
+  "endpoint": "https://spliceai-38-xwkwwwxdwq-uc.a.run.app/spliceai/",
+  "genome_assembly": "GRCh38",
+  "distance": 500,
+  "mask": 1,
+  "certificate_verification_disabled": false,
+  "sets": [
+    {
+      "name": "chromosome-balanced-random",
+      "sampling_design": "Four uniformly sampled production records per primary chromosome",
+      "seed": 20261003,
+      "queries": 96,
+      "comparisons_performed": 96,
+      "matched_mane_select": 96,
+      "response_parameters_match": 96,
+      "local_unscored": 0,
+      "position_fields_different": 0,
+      "max_score_difference": 0.005,
+      "passed": true
+    },
+    {
+      "name": "chromosome-balanced-high-score",
+      "sampling_design": "One randomly selected variant-gene pair with maximum local delta score at least 0.20 per primary chromosome",
+      "seed": 20261004,
+      "queries": 24,
+      "comparisons_performed": 24,
+      "matched_mane_select": 24,
+      "response_parameters_match": 24,
+      "local_unscored": 0,
+      "position_fields_different": 0,
+      "max_score_difference": 0.0050000000000000044,
+      "passed": true
+    }
+  ],
+  "combined": {
+    "queries": 120,
+    "comparisons_performed": 120,
+    "matched_mane_select": 120,
+    "response_parameters_match": 120,
+    "local_unscored": 0,
+    "position_fields_different": 0,
+    "max_score_difference": 0.0050000000000000044,
+    "passed": true
+  },
+  "interpretation": "The public VCF stores scores to two decimal places and the Broad response stores three; a maximum difference of 0.005 is consistent with two-decimal quantization."
+}

metadata/chromosomes/chr1.json

@@ -0,0 +1,16 @@
+{
+  "status": "passed",
+  "contig": "1",
+  "file": "data/spliceai-mane-v1.5-d500-m1.snv.chr1.vcf.gz",
+  "index_file": "data/spliceai-mane-v1.5-d500-m1.snv.chr1.vcf.gz.tbi",
+  "records": 303270507,
+  "source_vcf_sha256": "def5b0903fc4c3f3791e13fea97aa694dd38d9568d541cdf1a7ffcd323ff58e9",
+  "record_body_sha256": "7158aeddc348e08a34e1098c2b33c2cacd1d4956bada2901c044caffbe2fa5ab",
+  "vcf_sha256": "29cb0e70c3b6d75a4693170ffeeb758b5f5ce1ed2406eebdf106543c86623968",
+  "index_sha256": "df20352836c000ecdc2f6035921b927639b3ede009d56000603f6b8dc039b277",
+  "vcf_bytes": 3050347481,
+  "index_bytes": 117186,
+  "header_sanitized": true,
+  "records_byte_identical_to_audited_source": true,
+  "completed_at": "2026-10-03T19:42:51.466299+00:00"
+}

metadata/chromosomes/chr10.json

@@ -0,0 +1,16 @@
+{
+  "status": "passed",
+  "contig": "10",
+  "file": "data/spliceai-mane-v1.5-d500-m1.snv.chr10.vcf.gz",
+  "index_file": "data/spliceai-mane-v1.5-d500-m1.snv.chr10.vcf.gz.tbi",
+  "records": 171040761,
+  "source_vcf_sha256": "6c0ce0d1ac0be9db6cebe3452bc43135b43b1b8cfc9da631dcdca44c3fdcc13f",
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+  "vcf_sha256": "bd473f11506a420f5710f74434e2ba9ef4f7c71565d1fce5a5591dc5bc83ef0c",
+  "index_sha256": "c4a4a7a59f6ce33927860eb012fda55d3039305515e1cf0d9ef52ff48622bf98",
+  "vcf_bytes": 1721877711,
+  "index_bytes": 58659,
+  "header_sanitized": true,
+  "records_byte_identical_to_audited_source": true,
+  "completed_at": "2026-10-03T19:44:22.510625+00:00"
+}

metadata/chromosomes/chr11.json

@@ -0,0 +1,16 @@
+{
+  "status": "passed",
+  "contig": "11",
+  "file": "data/spliceai-mane-v1.5-d500-m1.snv.chr11.vcf.gz",
+  "index_file": "data/spliceai-mane-v1.5-d500-m1.snv.chr11.vcf.gz.tbi",
+  "records": 170523186,
+  "source_vcf_sha256": "80a99a2a89c7f5ab3bf9546b6ceb6216e3507611caf21084d67381deabc869c3",
+  "record_body_sha256": "87fd34cdaf9f4253db6eafcf8e118bdb601764dc20e6bee4425fb2f0baf72e32",
+  "vcf_sha256": "890a235c7e12d4a9cf8293e36a6f2fbaf82a5089e44270dfcde85a5a83e9eb8e",
+  "index_sha256": "ec565feeac869bfc5e3a01025d2af5e07edea43d5440140734321e9e573b991d",
+  "vcf_bytes": 1718797413,
+  "index_bytes": 62106,
+  "header_sanitized": true,
+  "records_byte_identical_to_audited_source": true,
+  "completed_at": "2026-10-03T19:44:05.921426+00:00"
+}

metadata/chromosomes/chr12.json

@@ -0,0 +1,16 @@
+{
+  "status": "passed",
+  "contig": "12",
+  "file": "data/spliceai-mane-v1.5-d500-m1.snv.chr12.vcf.gz",
+  "index_file": "data/spliceai-mane-v1.5-d500-m1.snv.chr12.vcf.gz.tbi",
+  "records": 168421740,
+  "source_vcf_sha256": "1c430bbe362b698db6763f01ff3ce17d4bdf884334be736ec5469e8dccc87345",
+  "record_body_sha256": "5ed69f0658aeb44b67b7435590bc31006ced84e8290d8737d776332aa341e7ae",
+  "vcf_sha256": "5b20bd9bee396f3283ce80110779eb9518ec9fbe90faa053622693885f25d187",
+  "index_sha256": "56cf31fe46eb876424246481b0ee61919bdf56009f496ab61b229a34a80306e4",
+  "vcf_bytes": 1692803584,
+  "index_bytes": 62963,
+  "header_sanitized": true,
+  "records_byte_identical_to_audited_source": true,
+  "completed_at": "2026-10-03T19:44:23.307666+00:00"
+}

metadata/chromosomes/chr13.json

@@ -0,0 +1,16 @@
+{
+  "status": "passed",
+  "contig": "13",
+  "file": "data/spliceai-mane-v1.5-d500-m1.snv.chr13.vcf.gz",
+  "index_file": "data/spliceai-mane-v1.5-d500-m1.snv.chr13.vcf.gz.tbi",
+  "records": 88546665,
+  "source_vcf_sha256": "17093b80bb4f6295a8a8c76272c6ad75e6827c583e5896d244eb385c06aa76f9",
+  "record_body_sha256": "cc2bb300b32e1596ad97a27be15d2849b66ed8c313ef99957e1a2ce5723c1389",
+  "vcf_sha256": "5696127272eba15545e34c1b1366d95ca359b315244276b0db93f6225dbb0a9d",
+  "index_sha256": "b7057ae59188043a24c3828c6b500a47fa228ee34350ec2319983bab7f404d4c",
+  "vcf_bytes": 885414078,
+  "index_bytes": 33298,
+  "header_sanitized": true,
+  "records_byte_identical_to_audited_source": true,
+  "completed_at": "2026-10-03T19:43:21.168209+00:00"
+}

metadata/chromosomes/chr14.json

@@ -0,0 +1,16 @@
+{
+  "status": "passed",
+  "contig": "14",
+  "file": "data/spliceai-mane-v1.5-d500-m1.snv.chr14.vcf.gz",
+  "index_file": "data/spliceai-mane-v1.5-d500-m1.snv.chr14.vcf.gz.tbi",
+  "records": 104534424,
+  "source_vcf_sha256": "53fb94b427afc92fcf6b1d6f7a96fff6ecbb6c0a480708fe4021bced60a7aad0",
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+  "vcf_sha256": "34d821ef3de765be6a69fe1e3d6601e8bd5104e529150313c1b120e3e3795568",
+  "index_sha256": "33c95f949937916fd3ae35a0bd240e5a2f4fb847d16345b966adce45942aa5c9",
+  "vcf_bytes": 1049756034,
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+  "header_sanitized": true,
+  "records_byte_identical_to_audited_source": true,
+  "completed_at": "2026-10-03T19:44:23.520211+00:00"
+}

metadata/chromosomes/chr15.json

@@ -0,0 +1,16 @@
+{
+  "status": "passed",
+  "contig": "15",
+  "file": "data/spliceai-mane-v1.5-d500-m1.snv.chr15.vcf.gz",
+  "index_file": "data/spliceai-mane-v1.5-d500-m1.snv.chr15.vcf.gz.tbi",
+  "records": 113256723,
+  "source_vcf_sha256": "dcf2c9bb2cfe8d6d8720e1924a87475827146728ecf656bbf2da94632eaa1806",
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+  "vcf_sha256": "cc873312d984295393fd374f8f19442cda4a57cd5fdde8e75f2fdb975030fa5b",
+  "index_sha256": "20ed9e4d995e04289ef60a39921534f7875f380984f8c23dfa7ca9cd3386a7b3",
+  "vcf_bytes": 1141891885,
+  "index_bytes": 42189,
+  "header_sanitized": true,
+  "records_byte_identical_to_audited_source": true,
+  "completed_at": "2026-10-03T19:45:44.568547+00:00"
+}

metadata/chromosomes/chr16.json

@@ -0,0 +1,16 @@
+{
+  "status": "passed",
+  "contig": "16",
+  "file": "data/spliceai-mane-v1.5-d500-m1.snv.chr16.vcf.gz",
+  "index_file": "data/spliceai-mane-v1.5-d500-m1.snv.chr16.vcf.gz.tbi",
+  "records": 101622477,
+  "source_vcf_sha256": "729ce3c2b6800fde44a0f5eb901343866378af04e9976bdb059e102b933f56b0",
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+  "vcf_sha256": "c86a86be08a54d22e282615ac02202b1286c4916e8952d025526d8fa6796fb0a",
+  "index_sha256": "77c396eb36949b8e5c3b5bd5b4acdeba169038d9fbd54a83db873efba33dabad",
+  "vcf_bytes": 1029091192,
+  "index_bytes": 40737,
+  "header_sanitized": true,
+  "records_byte_identical_to_audited_source": true,
+  "completed_at": "2026-10-03T19:45:48.528631+00:00"
+}

metadata/chromosomes/chr17.json

@@ -0,0 +1,16 @@
+{
+  "status": "passed",
+  "contig": "17",
+  "file": "data/spliceai-mane-v1.5-d500-m1.snv.chr17.vcf.gz",
+  "index_file": "data/spliceai-mane-v1.5-d500-m1.snv.chr17.vcf.gz.tbi",
+  "records": 121414488,
+  "source_vcf_sha256": "869aadfebcb1bd89f0a9da49d6258b75aaa4ed9935f35e8b6819444efdfba4a3",
+  "record_body_sha256": "998f697b26e9065834aaeaa91ca150a462d8a77256202d90f8f0dd9466c3aed4",
+  "vcf_sha256": "b43c8183fa94af812f6fbac2573d792b3b77630562a6a1103c50f172968bb1d6",
+  "index_sha256": "1ef88d3245d25b2371eb5cf60993db30fb298c7958f97aec5d1e82b36cdbda8b",
+  "vcf_bytes": 1230577929,
+  "index_bytes": 48158,
+  "header_sanitized": true,
+  "records_byte_identical_to_audited_source": true,
+  "completed_at": "2026-10-03T19:46:21.113155+00:00"
+}

metadata/chromosomes/chr18.json

@@ -0,0 +1,16 @@
+{
+  "status": "passed",
+  "contig": "18",
+  "file": "data/spliceai-mane-v1.5-d500-m1.snv.chr18.vcf.gz",
+  "index_file": "data/spliceai-mane-v1.5-d500-m1.snv.chr18.vcf.gz.tbi",
+  "records": 81448443,
+  "source_vcf_sha256": "4fa2c7f2cd5a324b2dec6392dae57a0d909854515d68ae65cb0c995f1724b128",
+  "record_body_sha256": "ad36a41ebdd3eb63d033c0df595d07a7d4a55264354774edfbc51ac7844e6dcc",
+  "vcf_sha256": "11b54f06d3c5b93c972072ccd905ea5af8526f21e80ec8d82a98a0523da7e0d9",
+  "index_sha256": "8b2034f99aac2cd1dbc8efb71dec2b1d23e55864dffb65864f16c9907147605b",
+  "vcf_bytes": 814055491,
+  "index_bytes": 27429,
+  "header_sanitized": true,
+  "records_byte_identical_to_audited_source": true,
+  "completed_at": "2026-10-03T19:45:18.746452+00:00"
+}

metadata/chromosomes/chr19.json

@@ -0,0 +1,16 @@
+{
+  "status": "passed",
+  "contig": "19",
+  "file": "data/spliceai-mane-v1.5-d500-m1.snv.chr19.vcf.gz",
+  "index_file": "data/spliceai-mane-v1.5-d500-m1.snv.chr19.vcf.gz.tbi",
+  "records": 83305044,
+  "source_vcf_sha256": "0592826c781f383976b73eb633def2a6ec053af2390590d95426ca21a4e291c2",
+  "record_body_sha256": "77586e526d6cbd1dc9172fe5101359ef52417fca2b051683299ce5d6c26fd668",
+  "vcf_sha256": "af571fa2273fdae57d6b9b21400a15c42c4a1b725b1a65c548ed9e15f9b12587",
+  "index_sha256": "09bd7171b285d905e4fc9ce06331cd3f03a838f6bf581920c6b4a21cc67032c6",
+  "vcf_bytes": 849404042,
+  "index_bytes": 38014,
+  "header_sanitized": true,
+  "records_byte_identical_to_audited_source": true,
+  "completed_at": "2026-10-03T19:46:16.984035+00:00"
+}

metadata/chromosomes/chr2.json

@@ -0,0 +1,16 @@
+{
+  "status": "passed",
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+  "file": "data/spliceai-mane-v1.5-d500-m1.snv.chr2.vcf.gz",
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metadata/chromosomes/chr21.json

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metadata/chromosomes/chr4.json

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metadata/chromosomes/chr5.json

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metadata/chromosomes/chr6.json

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