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Targeting Underlying Inflammation in Carcinoma Is Essential for the Resolution of Depressiveness | 412ac2da-3d0f-4572-b520-4b82115a944f | 10000718 | Internal Medicine[mh] | Treating patients with cancer is challenging. In modern clinical practice and research on behavioral changes in patients with oncologic problems, there are several one-sided approaches to this problem. Oncologists are concerned in great detail with localization of the primary oncologic process, pre- and post-operative ... |
Cytological Samples: An Asset for the Diagnosis and Therapeutic Management of Patients with Lung Cancer | 98873e9a-130b-44b1-9558-aa645382e242 | 10001120 | Anatomy[mh] | Lung cancer has become the leading cause of cancer death for men and women . The management of this cancer has evolved over the last decade with the emergence of new therapies, such as tyrosine kinase inhibitors and immunotherapy. Therefore, patient samples must allow for both the diagnosis and molecular testing, as we... |
A Novel Technique of Amniotic Membrane Preparation Mimicking Limbal Epithelial Crypts Enhances the Number of Progenitor Cells upon Expansion | c0b49748-feb6-4135-9fa1-15fdb55b159c | 10001367 | Anatomy[mh] | The homeostasis of the dynamic cellular organization in the cornea mainly depends on the regenerative efficiency of the stem cells in the surrounding limbus . Tissue-specific human limbal epithelial stem cells (hLESCs) residing in the limbal epithelial crypts of the palisades of Vogt continuously compensate for the lo... |
Digital Health Literacy and Person-Centred Care: Co-Creation of a Massive Open Online Course for Women with Breast Cancer | b916f2db-4cef-467a-9228-d54798087089 | 10001393 | Patient-Centered Care[mh] | Breast cancer (BC) represents one of the most frequently diagnosed cancers in women worldwide . According to the most recent data from the European Cancer Information System (ECIS), there were approximately 355,460 new cases of BC diagnosed across Europe in 2020, with 34,088 of those cases occurring in Spain . However,... |
Comparison of Frailty Assessment Tools for Older Thai Individuals at the Out-Patient Clinic of the Family Medicine Department | f54bceae-cb01-428e-bb96-f1a3598691db | 10001464 | Family Medicine[mh] | Frailty is defined as a reduction in the ability to cope with everyday or acute stressors, particularly among older adults . Frailty results in an increased vulnerability brought about by age-associated declines in physiological reserves and functioning across multiple organ systems . The consequences of this condition... |
Soil Fungal Community Structure and Its Effect on CO | 862ee59a-d5c1-4bdb-afd7-2d0b5f20723c | 10001496 | Microbiology[mh] | Saline soil accounts for more than 7% of the earth’s land surface, and approximately 70% of saline soil is used for agricultural production . However, the amount of saline soil increases by 10% every year , which is one of the most compelling environmental problems on a global scale. High salinity in soil inhibits plan... |
The Impact of Health Education on the Quality of Life of Patients Hospitalized in Forensic Psychiatry Wards | c1b3ae16-59f9-4b7d-a4e4-b339239996aa | 10001608 | Forensic Medicine[mh] | Research on the quality of life began in the early 1960s and 1970s, and in recent years this issue has received more structured interest from researchers in various fields of science. The concept of quality of life is ambiguous, multidimensional, and multidisciplinary, and reflects many aspects of human functioning. To... |
The Effect of Spring Barley Fertilization on the Content of Polycyclic Aromatic Hydrocarbons, Microbial Counts and Enzymatic Activity in Soil | 9519a542-8fe6-40a0-8db0-9a83b79982fd | 10001663 | Microbiology[mh] | Environmental pollution caused by polycyclic aromatic hydrocarbons (PAHs) poses one of the greatest problems in the contemporary world. Polycyclic aromatic hydrocarbons (PAHs) are considered to be especially toxic to humans, likewise to plants, microorganisms and other living organisms. PAH toxicity is a well-known fac... |
A Model for Predicting and Grading the Quality of Grain Storage Processes Affected by Microorganisms under Different Environments | 43d57b17-d1c3-430e-b827-0142a31cc328 | 10001665 | Microbiology[mh] | Fusarium and Aspergillus are the main pathogenic fungi of grain and oil crops . In warm and humid areas, serious diseases will reduce the quality of crops such as wheat and corn, posing a serious threat to grain and oil production. Once the temperature and humidity of grain storage environments change, it is susceptibl... |
People’s Willingness to Pay for Dental Checkups and the Associated Individual Characteristics: A Nationwide Web-Based Survey among Japanese Adults | f754554e-f76d-4f5c-a67c-0ba853769fe2 | 10001831 | Dental[mh] | Maintaining good oral health hygiene entails routine dental checkups and consulting dentists to diagnose underlying dental diseases. Apart from maintaining masticatory function, good oral health conditions contribute to an enhanced quality of life and reduce the impact of systemic non-communicable diseases . Therefore... |
Enhancing Medical Students’ Knowledge and Performance in Otolaryngology Rotation through Combining Microlearning and Task-Based Learning Strategies | fd3dee44-df3b-4977-a0ec-794620c6f5e9 | 10001912 | Otolaryngology[mh] | Generation Z medical students, born between 1995 and 2012, have specific learning preferences and seek personalized learning opportunities that help them achieve optimal use of time and resources. They enjoy short activities and desire to have access to their learning needs independently in the moment with the help of ... |
Development of a Person-Centred Integrated Care Approach for Chronic Disease Management in Dutch Primary Care: A Mixed-Method Study | 59b9a982-1d59-47de-8e0b-c5da4820b638 | 10001916 | Patient-Centered Care[mh] | Over the last decades, the increasing prevalence of chronic diseases has cast a huge burden on healthcare systems worldwide . Currently, chronic diseases are the leading cause of death globally, with cardiovascular diseases, diabetes, and chronic lung diseases causing the highest mortality . In the Netherlands, 59% of ... |
Health Communication in the Time of COVID-19 Pandemic: A Qualitative Analysis of Italian Advertisements | 6e2c9296-965c-4757-b883-6b5822475b29 | 10001965 | Health Communication[mh] | The onset of the COVID-19 pandemic between the end of 2019 and the beginning of 2020 represented a phenomenon strongly correlated to a climate of great health uncertainty. After China, Italy was the second largest country with the most immediate and widespread diffusion of the SARS-CoV-2 virus. These data characterized... |
Availability of Medical Services and Teleconsultation during COVID-19 Pandemic in the Opinion of Patients of Hematology Clinics—A Cross-Sectional Pilot Study (Silesia, Poland) | dd1cacca-528c-46f0-bac4-19011859dd68 | 10002034 | Internal Medicine[mh] | For a long time, coronaviruses were considered benign pathogens that cause respiratory symptoms of minor severity that resolve within a few days. The arrival of new infectious virus species has given rise to an increase in interest in these viruses. Before the emergence of the new SARS-CoV-2 coronavirus, a highly infec... |
Efficacy and Accuracy of Maxillary Arch Expansion with Clear Aligner Treatment | 0f94e149-f825-4521-a49a-dfa50e2d22c4 | 10002100 | Dental[mh] | The term “clear align therapy (CAT)” refers to the orthodontic technique with clear aligners for the treatment of dental malocclusions [ , , ]. Since its development in 1997, Invisalign ® technology has been established worldwide as an aesthetic alternative to labial fixed appliances . Since its first appearance on the... |
TLIF Online Videos for Patient Education—Evaluation of Comprehensiveness, Quality, and Reliability | abac38bc-63d3-412e-bddb-41c79449ce22 | 10002268 | Patient Education as Topic[mh] | Transforaminal lumbar interbody fusion (TLIF) surgery is an established procedure to treat a wide range of lumbar spine pathologies, e.g., degenerative pathologies, trauma, and infection . Moreover, the volume of lumbar fusion surgery and consequently revision surgery is constantly increasing, thus imposing a significa... |
Organisational Impact of a Remote Patient Monitoring System for Heart Failure Management: The Experience of 29 Cardiology Departments in France | ebd68c4f-982d-4c13-af1d-cde39e5e3327 | 10002348 | Internal Medicine[mh] | Chronic heart failure (CHF) is a global pandemic that currently affects the lives of 64 million people worldwide and 2.3% of the French population . The condition is characterised by a high mortality rate in the post-discharge period and a high likelihood of hospital readmission for acute, decompensated heart failure ... |
Three Experimental Common High-Risk Procedures: Emission Characteristics Identification and Source Intensity Estimation in Biosafety Laboratory | 9626d27d-24b4-4feb-895a-9e727f2c3d53 | 10002466 | Microbiology[mh] | The frequent occurrence of infectious diseases such as novel coronavirus and SARS-CoV-2 has seriously affected human health and the social economy [ , , , ]. There are numerous reports on the transmission of infectious microbes in the form of aerosols [ , , ]. Biosafety laboratories have a set of preventive measures re... |
Molecular Pathology, Diagnostics and Therapeutics: A Story of Success in 2022 | b530cd6a-e23e-4374-ad9e-c04dd29c2e33 | 10002953 | Pathology[mh] | Molecular pathology, diagnostics and therapeutics are three closely related topics of critical importance in medical research and clinical practice. Understanding the biology of diseases at the molecular level by identifying molecular and pathway alterations is important for several reasons: It can facilitate earlier a... |
Diagnostic Performance of Immunohistochemistry Compared to Molecular Techniques for Microsatellite Instability and p53 Mutation Detection in Endometrial Cancer | 4a794e4c-97b7-4606-8ff2-eec124a74b9a | 10002995 | Anatomy[mh] | Endometrial cancer (EC) is the sixth most frequent female cancer, affecting mainly post-menopausal women . The incidence of EC increased by 132% between 1999 and 2019, with the highest progression in developed countries. In contrast to EC incidence, EC mortality rates significantly decreased in around half of countries... |
Proteomics as a New-Generation Tool for Studying Moulds Related to Food Safety and Quality | a4fd87e1-593b-47dd-bf75-9b8fc290227d | 10003330 | Microbiology[mh] | Moulds are a key microbial group in the food industry, since they are capable of growing in a wide range of environmental conditions. Firstly, the application of moulds and derived products to produce and preserve food and food ingredients is very broad . Mould enzymes are ubiquitous, used in starch processing, in the ... |
A Semi-Automatic Method for the Quantification of Astrocyte Number and Branching in Bulk Immunohistochemistry Images | 22545ba4-1073-4470-b8e0-63f0a97bc6c0 | 10003611 | Anatomy[mh] | Astrocytes are glial cells representing a prominent component of the central nervous system (CNS), which participate in tissue homeostasis throughout the several stages of development, injury, and infection, as well as in the modulation of neuronal and immune responses . Astrocytes have a star-shaped morphology and exp... |
Pharmacokinetic Markers of Clinical Outcomes in Severe Mental Illness: A Systematic Review | 4deefeca-95da-4054-a0b8-a33cc52f2872 | 10003720 | Pharmacology[mh] | Mental and substance use disorders are leading causes of disability on a global level , with a significant portion of this burden deriving from severe mental illnesses (SMIs) . Collectively, SMI represents an ill-defined category which has been inconsistently reported in the literature in the field but that, as a bare... |
Predicting response to neoadjuvant therapy with glucose transporter-1 in breast cancer | 1655d28e-a792-4bbe-9ee7-5aaf658d6ee9 | 10004294 | Anatomy[mh] | Breast cancer (BC) is the most common tumor worldwide with a high mortality rate among women. Some parameters, such as tumor stage, molecular subtyping, and hormone receptor status, are used in the selection of treatment and in predicting the prognosis . Molecular subtyping is the most important parameter that predicts... |
LC-MS/MS Application in Pharmacotoxicological Field: Current State and New Applications | 1e95c4de-2e09-4f52-b826-8a168fb25479 | 10004468 | Forensic Medicine[mh] | This review aims to analyze the applications of liquid chromatography combined with mass spectrometry (LC-MS) in honor of the inventor of this powerful analytical instrument, Professor Gérard Hopfgartner. Analytical chemistry has a crucial role in preclinical and clinical studies, primarily regarding deaths and toxicit... |
Predicting the eyebrow from the orbit using three-dimensional CT imaging in the application of forensic facial reconstruction and identification | df9b1956-4305-4947-bff1-7d48127dd73c | 10006220 | Forensic Medicine[mh] | Identifying the remains of a missing person, especially those whose faces cannot be recognized due to decomposition or skeletonization is often difficult for law enforcement and investigative agencies . Moreover, this is especially true when evidence cannot be obtained from objective identifiable methods such as DNA, f... |
Root exudate-derived compounds stimulate the phosphorus solubilizing ability of bacteria | f789bebe-962b-4137-9989-bc7eed997cc5 | 10006420 | Microbiology[mh] | Most of the existing phosphorus (P) in soils globally is locked in primary minerals, absorbed on soil particle surfaces, or occurs in organically complexed forms , . Although P fertilizer is readily available for plants, once applied to soils, it faces constraints such as poor diffusion, limited solubility, and fixatio... |
Electronic consultation use by advanced practice nurses in older adult care—A descriptive study of service utilization data | 19d887b8-2175-473c-9faa-3b4d0f306fa3 | 10006590 | Internal Medicine[mh] | INTRODUCTION Older adults frequently face challenges when accessing care (World Health Organization, ). In a recent poll, 2 million Canadians aged 55+ identified difficulties seeing a primary care provider (PCP), and long wait times for physician specialist care, surgery and diagnostic tests as challenges encountered i... |
Integration of Task-Based Exoskeleton with an Assist-as-Needed Algorithm for Patient-Centered Elbow Rehabilitation | ae8a6e66-0f6d-4f06-9be4-a3f198632325 | 10006945 | Patient-Centered Care[mh] | As people get older, they may experience age-related neuromuscular and sensorimotor degeneration, resulting in disabilities and limiting the range of motion (ROM) of joints and coordination. With an aging population, healthcare systems will face significant challenges to meet the growing demand. The COVID-19 pandemic h... |
What can autopsy say about COVID-19? A case series of 60 autopsies | cab81bad-d0ed-4785-92d1-1cae0fbab184 | 10008096 | Forensic Medicine[mh] | Introduction In COVID-19 patients, respiratory failure, septic shock and multiple organ failure are the main causes of death. COVID-19 average case-fatality ratio (CFR, the number of deaths per 100 confirmed cases) is about 2–3% . Age is the main predictor of death, followed by comorbidities such as diabetes, and hyper... |
Potential use of telemedicine in paediatrics: a single-centre retrospective review | 384afd6e-399c-4ea7-83d6-594935daca94 | 10008200 | Pediatrics[mh] | During the COVID-19 pandemic, telemedicine saw over a 600% increase in usage as the healthcare industry transitioned away from in-person care. Outside of a pandemic setting, telemedicine, particularly in the paediatric space, also has the potential to provide broader reach and access in areas without these resources. A... |
Color-resolved Cherenkov imaging allows for differential signal detection in blood and melanin content | d460d166-6d1f-49e3-bd06-c7d565826f5c | 10008915 | Internal Medicine[mh] | Introduction Radiotherapy is used in ∼ 50 % of cancer patients’ therapy. , Few measurement devices such as thermoluminescent dosimetry or optically stimulated luminescent dosimetry exist to verify dose to tissues and are usually limited to point dose determination. At present, no available technique can quickly and rea... |
Lung Cancer Screening Knowledge in Four Internal Medicine Programs | 7195ed34-b782-4eca-8923-0cef7bcb1a7f | 10009012 | Internal Medicine[mh] | The mortality burden of lung cancer in the United States remains elevated despite reducing smoking rates and better treatments. An initial lung cancer presentation in advanced stages is common due to the asymptomatic nature of most early stage disease. The last decade has seen a substantial increase in lung cancer scre... |
Integrating Palliative Care into Oncology Care Worldwide: The Right Care in the Right Place at the Right Time | e8264627-3b23-4c7f-a2b1-ba8f88753c47 | 10009840 | Internal Medicine[mh] | Palliative care is defined as an approach that improves the quality of life of patients and their families facing problems associated with life-threatening illness through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems, physical... |
Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type primary glioblastoma | 2437ba5c-2928-4d80-b217-100e64acbd06 | 10010007 | Pharmacology[mh] | Isocitrate dehydrogenase wild-type (IDH-wt) glioblastoma (GBM) constitutes the most common and aggressive GBM subtype, with high inter- and intra-tumoral heterogeneity . Temozolomide (TMZ), in addition to radiotherapy and surgical resection, can improve both the progression-free survival (PFS) and overall survival (OS)... |
Observations on strategies used by people with dementia to manage being assessed using validated measures: A pilot qualitative video analysis | 32a01ca4-8f35-4dfc-a151-42ed568fcbdf | 10010081 | Patient Education as Topic[mh] | INTRODUCTION Growing evidence shows that people with dementia can report their views and experiences in research. , However, an area that has been little researched is how people with dementia react while being assessed using validated measures or what strategies they use in this situation. Validated measures in health... |
Accompanying patients in clinical oncology teams: Reported activities and perceived effects | 57bd7008-8a82-462c-9e09-b9a9ea7b13c0 | 10010089 | Internal Medicine[mh] | INTRODUCTION It is estimated that in 2022, 60,000 Quebecers were diagnosed with cancer, which represents 158 new cases per day. This number has been on the rise for several years and is expected to continue rising in the coming years due to testing delays and backlogs following the pandemic. Cancer is the country's lea... |
Tumour Suppressor Neuron Navigator 3 and Matrix Metalloproteinase 14 are Co-expressed in Most Melanomas but Downregulated in Thick Tumours | 768e3bee-dc25-498a-9b5d-2f560dab1b85 | 10010123 | Anatomy[mh] | Patient samples and melanoma cell lines The study was approved by the Ethics Committee of Southern Finland (Dnr 492/E5/05 and 208/E5/01). Archival, paraffin-embedded tissue samples of primary melanomas ( n = 27) and histologically benign naevi ( n = 15), obtained for diagnostic purposes from patients treated at the Tam... |
Fetoscopic endoluminal tracheal occlusion with Smart-TO balloon: Study protocol to evaluate effectiveness and safety of non-invasive removal | 16183841-6594-48b9-b56b-f3ef6d0c0e9d | 10010565 | Pediatrics[mh] | Background Congenital diaphragmatic hernia (CDH) is a birth defect characterized by failed closure of the diaphragm. This enables abdominal viscera to herniate into the thoracic cavity, leading to hypoplastic lungs and impaired lung vasculature . Fetoscopic Endoluminal Tracheal Occlusion (FETO) increases fetal lung vol... |
Person-centered care approach to prevention and management of falls among adults and aged in a Brazilian hospital: a best practice implementation project | e0cb242c-4729-47b8-b673-481e278eaca6 | 10010697 | Internal Medicine[mh] | Falls in the hospital environment are a cause for concern among health professionals because this adverse event may result in injuries and higher healthcare costs, compromise the quality of care, and generate ethical and legal implications for health institutions. – The worldwide incidence of falls in hospital is aroun... |
Network expansion of genetic associations defines a pleiotropy map of human cell biology | 59f793e9-1b61-4141-9382-c04377783076 | 10011132 | Anatomy[mh] | Proteins that interact tend to take part in the same cellular functions and be important for the same organismal traits , . Through a principle of guilt-by-association, it has been shown that molecular networks can be used to predict the function or disease relevance of human genes – . On the basis of this, protein int... |
Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation | e9a1d93b-3445-47fa-89a5-a67f61656df9 | 10011328 | Internal Medicine[mh] | Randomized controlled trials are the cornerstone for reliably evaluating therapeutic strategies. However, during the past 25 years, the rules and regulations governing randomized trials and their interpretation have become increasingly burdensome, and the cost and complexity of trials has become prohibitive. The presen... |
Evaluating the use of large language model in identifying top research questions in gastroenterology | bf1cea70-d16e-4752-8516-60f4eeb60531 | 10011374 | Internal Medicine[mh] | The field of gastroenterology (GI) is constantly evolving, with new advances in technology and research offering insights into the diagnosis and treatment of GI conditions . In order to continue pushing the field forward, it is essential to identify the most important research questions that require further investigati... |
Spinach ( | 6c4f6c54-fa42-4bef-bf60-20001f90ae11 | 10011398 | Microbiology[mh] | Continuous monocropping is a modern agricultural practice in many parts of the world to increase yield on limited land – . To achieve and maintain high yields and economic benefits, high-value crop production is managed intensively year-round by applying high input chemical fertilizers and agricultural pesticides , . H... |
A sequential, multiple assignment randomized trial comparing web-based education to mobile video interpreter access for improving provider interpreter use in primary care clinics: the mVOCAL hybrid type 3 study protocol | 5a7af81a-34f1-49d1-969d-fe610684f1fc | 10012737 | Patient-Centered Care[mh] | Effective communication is essential for safe and equitable care. Twenty-five million people in the United States of America (USA) report speaking English less than “very well” and, as a result, have limited access to safe and high-quality medical care . Language barriers in healthcare are associated with lower patient... |
Impacts of coniferous bark-derived organic soil amendments on microbial communities in arable soil – a microcosm study | 2fc9ac59-40ce-473c-8a8a-326604ecb3d2 | 10013654 | Microbiology[mh] | Deforestation and conversion of land to agriculture depletes one third of the soil carbon (C) pool during the first 10 years and thereafter continues, for example, in Finland at a rate of 0.4% yr −1 (Heikkinen et al. ), which is in line with estimations of LUCAS surveys conducted from European arable soils (Panagos et ... |
The potential and pitfalls of artificial intelligence in clinical pharmacology | 1355fdf3-d5d0-4484-bcc8-83e8e1eb8138 | 10014043 | Pharmacology[mh] | For decades, clinical pharmacologists have embraced the mathematical representation of physiology and explored modeling options to derive relationships between drug and temporal changes in pharmacokinetics (PK) and pharmacodynamics. Now, as an evolution toward defining better therapies, we strive toward more digitizati... |
Quantitative systems pharmacology of the eye: Tools and data for ocular QSP | f703078a-7ecd-4f35-86f6-306d72ec9486 | 10014063 | Pharmacology[mh] | Diseases of the eye The eye is the most important sensory organ in the human body and visual impairment places a huge burden on affected patients. Leading causes for irreversible visual impairment are cataracts, age‐related macular degeneration (AMD), glaucoma, diabetic retinopathy, and retinitis pigmentosa. Furthermor... |
Monogenic disease analysis establishes that fetal insulin accounts for half of human fetal growth | bbbc5826-b553-46d5-8637-6bcf9c5415cd | 10014100 | Gynaecology[mh] | There was a substantial, global reduction in fetal growth in the absence of fetal insulin ( and ). Mean birth weight adjusted to 40 weeks’ gestation was 51% of normal birth weight (1,697 g [95% CI, 1,586–1,808 g] vs. 3,320 g [50th percentile at 40 weeks]) . Median birth length was greatly reduced and 12% lower than no... |
Impact of pharmacogenetics on aspirin resistance: a systematic review | e1c69724-d741-4e20-b028-663269ec476b | 10014202 | Pharmacology[mh] | Cardiovascular disease (CVD) is the first cause of mortality worldwide, with all the healthcare systems facing this very challenging issue. The World Health Organization (WHO) estimates that 31% of deaths worldwide are due to CVD, with ∼ 17.7 million CVD-related deaths in 2015. Approximately 7.4 million of these deaths... |
Machine learning approaches to predict drug efficacy and toxicity in oncology | 90095718-75e1-4e70-a261-df297eabfc70 | 10014302 | Internal Medicine[mh] | Machine learning algorithms (MLAs) are a set of algorithms within the field of artificial intelligence (AI) that can learn relevant relationships within large datasets and develop ideal approaches to their analysis without prior specification. , , , MLAs have found many applications in drug development, including FDA a... |
High-efficiency pharmacogenetic ablation of oligodendrocyte progenitor cells in the adult mouse CNS | 053359c6-95df-4421-aeff-46e61000d05c | 10014347 | Pharmacology[mh] | Oligodendrocyte progenitor cells (OPCs) are the principal mitotic cell type in the adult mammalian CNS. OPCs are known primarily for generating myelin-forming oligodendrocytes (OLs) during postnatal development and adulthood. , Although OPCs are distributed throughout the CNS, including in brain regions where relativel... |
Health care providers’ perspectives on providing end-of-life psychiatric care in cardiology and oncology hospitals: a cross-sectional questionnaire survey | a03ee174-e5a3-4644-9b87-6705e9d6f6f9 | 10014396 | Internal Medicine[mh] | Heart failure (HF) is potentially fatal, unless a heart transplantation is performed, and it is a serious healthcare and economic burden on patients and their caregivers. The World Health Organization estimated the worldwide mortality from cardiovascular disease at 15.2 million in 2016 , making it the most common cause... |
Evidence of D-shaped wounds in the intrasomatic bullet path: two case reports | 788ba8bb-7018-4d59-947c-d198c53b9cab | 10014649 | Forensic Medicine[mh] | Forensic ballistics can be defined as the study of the projectile’s behavior to reconstruct the defining events in the production of a gunshot wound (GSW) and is divided into internal, external, and terminal ballistics . While internal ballistics mostly focuses on the mechanisms of bullet ejection from the inside of th... |
1ed14ed3-ec94-46de-b0c1-aac929e11121 | 10014693 | Internal Medicine[mh] | The Small Business Innovation Research (SBIR) and the Small Business Technology Transfer (STTR) programs were established by the United States Congress to increase the commercialization of technologies developed by small businesses through federally funded research and development. The SBIR and STTR programs at the Nat... | |
Detecting DNA damage in stored blood samples | 85258e1f-edca-4566-9c28-637fd83fa72a | 10014702 | Forensic Medicine[mh] | Over the past decades, DNA profiling of biological crime scene traces by multiplex PCR analysis of short tandem repeat (STR) markers has become a very important tool in the investigation of crime. One of the main challenges forensic scientists encounter when working with biological trace evidence is DNA fragmentation r... |
Intramuscular hemorrhages in the pathway of an electric current through the body — two case reports | a128d2fc-a186-4189-8446-f4161e35d1ec | 10014766 | Forensic Medicine[mh] | The diagnosis of a death by electrocution is mainly made on the basis of the external findings. The flow of electric current through the human body has specific effects on the excitable tissues, but morphological signs may be sparse or even absent . The problem is further accentuated by the fact that there are no speci... |
Freiburg Neuropathology Case Conference | af4ef79b-da2b-4ae3-9259-eced8a2a7924 | 10014779 | Pathology[mh] | A 43-year-old male patient presented with a painless 5 mm exophthalmos of the right eye (OD), which had slowly developed over the past 12 months concurrently with a right-sided ptosis. He did not report any double vision. On examination the palpebral aperture measured 5 mm OD and 10 mm for the left eye (OS). There was ... |
Detection of | c77e023f-0cd6-4e88-81fc-045b3e822456 | 10015049 | Microbiology[mh] | Escherichia coli is a Gram-negative, facultative, anaerobic bacterium considered to be a commensal organism in the human body . However, the E. coli strain O157:H7 is a pathogen that poses a threat to human life by causing several diseases, such as haemolytic–uraemic syndrome (HUS), which may be fatal in some cases . T... |
Can Right-Sizing the Use of Virtual Care Improve Access to Equitable, Patient-Centered Care for Women Veterans? | 0738b891-10c3-473d-a351-f05d917d9be7 | 10015126 | Patient-Centered Care[mh] | |
Performance of infectious diseases specialists, hospitalists, and other internal medicine physicians in antimicrobial case-based scenarios: Potential impact of antimicrobial stewardship programs at 16 Veterans’ Affairs medical centers | 4e3efa3c-371a-4659-8bb9-1ceba4c5bd9c | 10015262 | Internal Medicine[mh] | The Cognitive Support Informatics for Antimicrobial Stewardship project enrolled 8 university-affiliated VA sites across the nation to participate in implementation of electronic antimicrobial dashboards that allow inter- and intrafacility comparisons of antimicrobial utilization across common inpatient conditions (eg,... |
Heidenhain Variant of Sporadic Creutzfeldt-Jakob Disease with a Variety of Visual Symptoms: A Case Report with Autopsy Study | 7dbce2e7-f865-4a8d-a402-4bd3885c453c | 10015505 | Forensic Medicine[mh] | Prion diseases are rapidly progressive and eventually fatal neurodegenerative disorders caused by accumulation of the transmissible scrapie form of the prion protein (PrP Sc ) following change of the normal cellular form of the prion protein (PrP) to PrP Sc in the central nervous system . Prion diseases are classified ... |
Developing a Novel Case-Based Gastroenterology/Hepatology Online Resource for Enhanced Education During and After the COVID-19 Pandemic | c9b03914-eae3-40aa-87ae-275976fc44f2 | 10015521 | Internal Medicine[mh] | Free open access medical education (FOAMed), accessible via computers and mobile devices were becoming increasingly preferred to traditional resources by trainees, even before the COVID-19 pandemic . Digital medical education platforms offer exciting and innovative modalities to augment the quality and variety of didac... |
Good clinical scores, no evidence of excessive anterior tibial translation, a high return to sport rate and a low re-injury rate is observed following anterior cruciate ligament reconstruction using autologous hamstrings augmented with suture tape | 3641d44b-3148-4d6a-9986-cc9089233c90 | 10015537 | Suturing[mh] | Anterior cruciate ligament reconstruction (ACLR) is common and, whilst a primary post-operative goal for many patients is a return to sport (RTS), it has been reported that across all patients, only 65% of patients return to their pre-injury level of sport . Furthermore, an overall secondary re-injury rate of 7% has b... |
Individual and environmental determinants associated with longer times to access pediatric rheumatology centers for patients with juvenile idiopathic arthritis, a JIR cohort study | 537ae31f-13e7-43cc-87f7-f62d6e758daf | 10015663 | Internal Medicine[mh] | Juvenile idiopathic arthritis (JIA) is the most common chronic pediatric rheumatic disease . It is defined by the onset, before age 16 years, of arthritis of unknown cause persisting for at least 6 weeks . The term JIA encompasses a heterogeneous group of different diseases classified into seven categories of varying s... |
Perspectives for Cancer Care and Research in Central and Eastern Europe | e9f91a3d-90ed-4506-836d-9b6dc820ceff | 10015746 | Internal Medicine[mh] | The present article reviews the domains of medical oncology education, human resources in oncology, cancer care, and clinical research in Central and Eastern European (CEE) in order to comprehensively assess the current situation and needs, describe important initiatives, and also propose ways to improving cancer outco... |
Navigating the electronic health record in university education: helping health care professionals of the future prepare for 21st century practice | 50047142-c80f-414a-8cb0-697d97589230 | 10016237 | Patient-Centered Care[mh] | |
Cost-effectiveness of running a paediatric oncology unit in Ethiopia | 1a8a84ac-283a-4037-9952-2d7722465c27 | 10016307 | Pediatrics[mh] | Globally, childhood cancer (age 0–19 years) represents 0.5%–4.6% of the total cancer burden in a population, and nearly 90% of this burden falls on low and middle-income countries (LMICs). In 2017, childhood cancer represented a disease burden of 11.5 million disability-adjusted life years (DALYs) globally and ranked a... |
Continuing medical education during a pandemic: an academic institution’s experience | a5a11794-1195-4b93-8520-3e4b3233c5ae | 10016839 | Preventive Medicine[mh] | |
Ophthalmological manifestations of COVID-19 and its transmissibility via ocular route | fc45d7b1-cbbb-4c4c-befe-0f35b95872c3 | 10016920 | Ophthalmology[mh] | postgradmedj-97-329-DC1-inline-supplementary-material-1 Click here for additional data file.
|
Rethinking infrastructure design: evaluating pedestrians and VRUs’ psychophysiological and behavioral responses to different roadway designs | 01d42e00-c3a7-4df3-ab1a-2598494345bd | 10017812 | Physiology[mh] | At its core, infrastructures are in fact an engineering product that have significant impact on people’s day to day lives. However, unlike many other products (e.g., smartphones, computers, etc.), we often overlook the importance of changing the design based on user feedback within the design phase. This is partly due ... |
The Role of Endoscopic Ultrasound in Hepatology | cc019524-fd2a-447c-9981-767fb4dd404e | 10018300 | Internal Medicine[mh] | Endoscopic ultrasound (EUS) has been an indispensable and widely used diagnostic tool since its initial description in the 1980s. Its diverse therapeutic and diagnostic applications have allowed for its use in various medical field, including gastroenterology, cardiology, and urology. , In recent years, EUS has also pr... |
Scalable Analysis
of Untargeted LC-HRMS Data by Means
of SQL Database Archiving | 777059c7-0702-4845-bfc0-e9093c59ab91 | 10018448 | Forensic Medicine[mh] | Liquid-chromatography-high-resolution
mass spectrometry (LC-HRMS)
is widely used for comprehensive screening of complex samples in environmental, forensic, clinical, and food chemistry.
The screening is considered comprehensive because it can cover chemicals
with a wide range of physiochemical properties and allows the... |
Medical physics practice guideline 4.b: Development, implementation, use and maintenance of safety checklists | f40ab8c9-1048-4c57-b2ea-ce3ba054602a | 10018656 | Internal Medicine[mh] | INTRODUCTION 1.1 Motivation: The value of checklists The field of medicine is characterized by highly complex and dynamic processes, where a multidisciplinary team works together using sophisticated imaging, planning, and delivery systems to provide efficient, accurate, and safe patient treatment, often under intense t... |
Quality management, quality assurance, and quality control in medical physics | 1d6a277b-8c92-4379-a517-d084cdb2c27c | 10018657 | Internal Medicine[mh] | INTRODUCTION A fundamental tenet in the practice of medicine involves maximizing clinical benefit to the patient, while minimizing associated risks to the patient including their caregivers. In the diverse applications spanning radiology, radiation oncology, nuclear medicine and molecular imaging, medical physics, and ... |
AAPM medical physics practice guideline 13.a: HDR brachytherapy, part A | 034c3460-e6af-49e4-b7f6-8b242c07ddb1 | 10018677 | Internal Medicine[mh] | DEFINITIONS AND ACRONYMS ABR : American Board of Radiology. ABS : American Brachytherapy Society. ACR : American College of Radiology. AMP : authorized medical physicist—an individual who meets the requirements listed in 10 CFR § 35. ASTRO : American Society for Radiation Oncology. AU : authorized user—a physician who ... |
Comparable clinical outcomes of culture-negative and culture-positive periprosthetic joint infections: a systematic review and meta-analysis | 76dd5e49-8259-4dee-a134-7e23c853363d | 10018887 | Debridement[mh] | Periprosthetic joint infection (PJI) is a catastrophic complication after total joint arthroplasty (TJA), with incidence of approximately 1% and 2% after total hip arthroplasty (THA) and total knee arthroplasty (TKA), respectively. Surgical treatment options of PJI include debridement, antibiotics and implant retenti... |
Future directions for medicinal chemistry in the field of oligonucleotide therapeutics | 43fab021-7f80-46b3-a4e2-8ea29437a006 | 10019366 | Pharmacology[mh] | Most researchers in the pharmaceutical industry in the early 1990s believed that oligonucleotides stood little chance of success as a new class of drug. Textbook knowledge stated that large polyanionic structures do not enter cells and thus, oligonucleotide drugs should not function in vivo. Furthermore, a manufacturi... |
The role of brain radiotherapy for EGFR- and ALK-positive non-small-cell lung cancer with brain metastases: a review | 114549cc-0239-489c-9d42-ad2afc2ded3e | 10020247 | Internal Medicine[mh] | Non-small cell lung cancer (NSCLC) is the first and second most frequent cause of death from cancer in men and women, respectively. Adenocarcinoma is the most represented histology with increasing incidence in western countries (> 50%) . Patients diagnosed in advanced or metastatic stage (mNSCLC) have poor prognosis wi... |
Evidence Regarding Pharmacogenetics in Pain Management and Cancer | fdee7606-0492-464a-9e38-d8dc93c891d9 | 10020807 | Pharmacology[mh] | |
Financial Disclosures Reported by Industry Among Authors of the American Academy of Ophthalmology Clinical Practice Guidelines | 9334e6e0-f8e5-478f-800a-fd2ec8772c51 | 10020930 | Ophthalmology[mh] | Rooted in evidence-based medicine, clinical practice guidelines (CPGs) use available scientific data to provide the latest recommendations with the goal of optimizing patient care. Guidelines can be subject to bias and conflicts of interest (COIs), which impact recommendations. Since the Physician Payments Sunshine Pro... |
Impact of Socio-demographic Characteristics on Time in Outpatient
Cardiology Clinics: A Retrospective Analysis | 45fcc136-56b2-4e94-9c9d-e89c2d99b02c | 10021097 | Internal Medicine[mh] | Time spent accessing healthcare is a key measure of service quality and
strain. , Elective surgery waiting times are the focus of most analyzes, and have
increased in recent years. However, patients wait in multiple settings—in the community
for primary care, specialist, , and allied health appointments,
and in waiting... |
Tap water as the source of a Legionnaires’ disease outbreak spread to several residential buildings and one hospital, Finland, 2020 to 2021 | 01fa1d31-7232-4107-b65b-6f8a7b44e1a2 | 10021472 | Microbiology[mh] | Legionnaires’ disease (LD) is an important cause of atypical pneumonia and can be community-acquired, travel-associated or nosocomial [ - ]. Besides age and having a weak immune system, or a chronic lung disease, former and current smokers are at increased risk for LD . Another risk factor is a stay at a hotel or simil... |
Paediatric emergency medicine practice in Nigeria: a narrative review | 46c839e9-160b-4edb-9001-e51cad725f7f | 10022062 | Pediatrics[mh] | The practice of paediatric emergency in low-middle income countries (LMICs), particularly in sub-Saharan Africa (SSA) has remained daunting owing to a lack of skilled manpower, infrastructure, and equipment . Although the special needs of children in SSA are well recognized, adequate response to the needs has not been ... |
Plasma phospho-tau in Alzheimer’s disease: towards diagnostic and therapeutic trial applications | 5c471d43-0bf6-4475-be31-0cc20ae0c37d | 10022272 | Pathology[mh] | As the leading cause of dementia worldwide, Alzheimer’s disease (AD) continues to present urgent strains on clinical care, public health efforts, palliative care and family systems . Although the ultimate confirmation of AD pathology is by autopsy examination of brain tissue for extracellular amyloid plaques made of am... |
An autopsy case of disseminated | 4c621e6a-e2e1-4844-bd3a-b48e06374681 | 10022292 | Forensic Medicine[mh] | Mucormycosis is an important infection that is associated with high mortality . In recent decades, its incidence has increased in populations with underlying conditions, such as those with malignancies and recipients of bone marrow transplant; among these, pulmonary mucormycosis is the primary cause at initial diagnosi... |
Post-explant profiling of subcellular-scale carbon fiber intracortical electrodes and surrounding neurons enables modeling of recorded electrophysiology | efdac400-9f09-402c-90da-c802932dbe74 | 10022369 | Physiology[mh] | Introduction Recording and interpreting neural activity in the mammalian cortex is paramount to understanding brain function and for controlling brain-machine interfaces (BMIs). Capturing the signals of individual neurons yields the most fundamental dynamics of neural activity (Harris et al , Hong and Lieber ), thereby... |
Dentists’ Self-evaluated Ability in Diagnosing and Updating About Pulpotomy | d457f6bc-e9cc-41d8-9809-6ecdd60d032d | 10023525 | Dental[mh] | Dental caries in children is a public health issue because it affects thousands, especially in developing countries. , , Besides caries, dental trauma can also involve the pulp, either reversibly or irreversibly. , Amongst the different vital pulp therapy techniques on primary teeth, pulpotomy is widely used and consis... |
The role of ferroptosis in prostate cancer: a novel therapeutic strategy | 2c7b2880-5efb-4203-8ec8-e97c877913a4 | 10023567 | Internal Medicine[mh] | Prostate cancer is the most common type of cancer among male urogenital system tumors . Prostate cancer is characterized by abnormal cell division in the prostate, resulting in abnormal growth of the prostate. Most men don’t die from prostate cancer, but are affected by slow-growing tumors. The death of prostate cancer... |
Quality of life changes over time and predictors in a large head and neck patients’ cohort: secondary analysis from an Italian multi-center longitudinal, prospective, observational study—a study of the Italian Association of Radiotherapy and Clinical Oncology (AIRO) head and neck working group | be303eb4-30a4-43e2-9feb-34d6d50200fe | 10023607 | Internal Medicine[mh] | Head and neck carcinoma (HNC) is becoming common worldwide, and it is anticipated to rise by 30% accounting for an estimated 1.08 million new cancer cases annually by 2030 . In particular, the increasing rates of human papilloma virus (HPV)-related tumors, with better prognosis compared to the counterpart, have contrib... |
Demographic and clinical characteristics determining patient-centeredness in endometriosis care | 32e1db2b-3c51-440b-b952-8a22e5b0b82b | 10023645 | Gynaecology[mh] | Endometriosis is a chronic, inflammatory gynecological disease affecting approximately 10% of all women in reproductive age . In many cases, endometriosis has a negative effect on women’s health-related quality of life (HRQoL) and is associated with lower emotional, physical, psychological, social and sexual health... |
Cancer burden in adolescents and young adults in Europe | 651a49de-62a5-42d4-9a14-501aa6fe6d8c | 10024081 | Internal Medicine[mh] | In Europe, many estimates of the burden of cancer in adolescents and young adults (AYAs) are derived from single centre or in single country data. Often different definitions of AYAs are used, , and therefore, the estimates are unreliable for the design of specialised clinical services that can meet their specific need... |
Off-label despite high-level evidence: a clinical practice review of commonly used off-patent cancer medicines | 7a11f1ee-bfb1-4b31-a123-0c1f30731b5c | 10024100 | Internal Medicine[mh] | Cancer is among the leading causes of death and an ongoing challenge for health care systems worldwide. During the last decade, a plethora of new medicines have been approved by regulatory bodies for the treatment of neoplastic diseases and in most countries, medicines are reimbursed according to their labelling indica... |
Design, power, and alpha levels in randomized phase II oncology trials | d7d60544-1001-4e5e-bf4f-af4770276a80 | 10024120 | Internal Medicine[mh] | Phase II trials are an important step in drug development because a successful trial can lead to further testing in phase III trials and/or drug approval, while an unsuccessful phase II trial may lead to a discontinuation in testing. Ideally, there would be a good balance between minimizing the premature termination of... |
Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer | 90b9fd9a-8459-431c-af74-5b0883a778d6 | 10024150 | Internal Medicine[mh] | Cancer of the corpus uteri (endometrial cancer) is the most common gynaecological malignancy in high- and intermediate-income countries. , In 2020, endometrial cancer was the sixth most commonly diagnosed cancer in women, with 417 367 new cases recorded, accounting for 2.2% of the new cancers diagnosed worldwide. Appro... |
Geriatric assessment and the variance of treatment recommendations in geriatric patients with gastrointestinal cancer—a study in AIO oncologists | 548d58a9-8d38-4179-b31e-886254601835 | 10024156 | Internal Medicine[mh] | The frequency of malignant tumors increases with age. The median age of onset was ∼70 years in 2018 in Germany. Similarly, it has been projected that by 2030 70% of all cancers will be diagnosed in older adults in the United States. While the burden of malignant diseases in the group of elderly persons is significantly... |
Association of Primary Care Physicians’ Individual- and Community-Level Characteristics With Contraceptive Service Provision to Medicaid Beneficiaries | eab3d5da-c144-475a-b341-6a43b0d421a3 | 10024198 | Gynaecology[mh] | Contraceptive care is a critical component of comprehensive health care that helps individuals achieve their preferred family size and birth spacing and is associated with improved health outcomes. However, this care is not uniformly accessible across the US. Disparities exist for vulnerable populations due to barriers... |
High Satisfaction with Patient-Centered Telemedicine for Hepatitis C Virus Delivered to Substance Users: A Mixed-Methods Study | ebf6aa90-6d06-4e51-a075-6dc10e7c0aa2 | 10024261 | Patient-Centered Care[mh] | Access to satisfactory health care can be challenging particularly for vulnerable populations. Telemedicine, two-way interaction between a patient and a provider separated geographically, may circumvent these obstacles. , Recent evidence-based systematic reviews have reported that telemedicine-based clinical outcomes a... |
Laboratory evaluation of the miniature direct-on-blood PCR nucleic acid lateral flow immunoassay (mini-dbPCR-NALFIA), a simplified molecular diagnostic test for | 0a860f16-3020-40ff-834f-15f23548ec82 | 10024383 | Pathology[mh] | Correct and timely diagnosis of malaria is key in the management and control of this disease. Traditionally, microscopy of Giemsa-stained thick and thin blood film has been the standard diagnostic technique applied in endemic settings. Although it is able to differentiate the causative Plasmodium species, its sensitivi... |
Exploring disease perception in Behçet’s syndrome: combining a quantitative and a qualitative study based on a narrative medicine approach | 69975861-2916-42fa-92d7-310f9cefcd99 | 10024433 | Patient-Centered Care[mh] | Behçet syndrome (BS) is a rare, chronic and multisystemic disorder affecting mucosa, skin, joints, eyes, nervous and gastrointestinal system. The multi-organ involvement and the wide range of clinical spectrum make often the management of BS challenging; moreover, the relapsing course of the disease can determine exace... |
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