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BRCA1 gene polymorphism and finger dermatoglyphic patterns in Ghanaian breast cancer patients: a quantitative cross-sectional approach
3b8dd4f7-8a93-4e9a-8018-8fdefa8fc134
10024563
Forensic Medicine[mh]
Cancer of the breast is a malignant disease that results from abnormal proliferation of cells within the breast tissue, which in advanced cases metastasize to other organs including bony skeleton, brain, lung and the liver . Globally in 2020 alone, breast cancer affected 2.3 million women with 685,000 deaths. This cont...
qPCR detection of viable
5330c940-37a7-40a5-9053-baa8e367f5e3
10024758
Microbiology[mh]
Although cosmetics do not need to be sterile, to protect the safety of people who use cosmetics, bacterial contamination above 1000 colony forming units (CFU/g or ml) is grounds for regulatory action in the United States (USA) and removal of contaminated products from the market; for products used around the eye area, ...
Diversity in Clinical Pharmacology: A Call to Action
9dc48fd4-eba7-4066-9407-bb2e7faf5804
10024964
Pharmacology[mh]
As a multidisciplinary scientific and medical field dedicated to the discovery, development, and optimal utilization of therapeutics, the field of clinical pharmacology is well positioned to further its contributions to the understanding of drug responses for all patient populations. Although analytical tools and techn...
Recommendations of the Spanish brachytherapy group of the Spanish Society of Radiation Oncology and the Spanish Society of Medical Physics for interstitial high-dose-rate brachytherapy for gynaecologic malignancies
305dafea-fb24-4672-af8f-098451531c59
10025210
Internal Medicine[mh]
Brachytherapy (BT) plays a key role in the treatment of gynaecological malignancies, especially for cervical and endometrial cancer. Various BT techniques are available. However, interstitial brachytherapy (ISBT) is considered essential in the treatment of cancers of the cervix (early stage or locally-advanced), vagina...
A comparative analysis of public and private dental benefit payer types for the provision and outcomes of root canal therapy on permanent teeth of children and adolescents in Massachusetts
30f1747a-1d82-4e7d-8af6-b2c94a4ed298
10026184
Dental[mh]
Data sources We used data from the Center for Health Information and Analysis, a state agency of Massachusetts. This Massachusetts All-Payer Claims Database includes dental claims and information on member eligibility, provider, and insurance type, which are collected from health insurance payers licensed to operate in...
Optimising adherence to secondary prevention medications following acute coronary syndrome utilising telehealth cardiology pharmacist clinics: a matched cohort study
691d2878-2faf-42f4-b40a-6aa35743d8a0
10026199
Internal Medicine[mh]
Implementing cardiology pharmacist telehealth clinics leads to improved medication adherence, and by extension improved clinical outcomes in patients following an acute coronary syndrome. This model of care is now a permanent component of care for patients following discharge for an acute coronary syndrome across a lar...
In silico designing and expression of novel recombinant construct containing the variable part of
7b13586a-2d31-4c06-afb5-58b8110770e5
10026285
Anatomy[mh]
INTRODUCTION Breast cancer (BC), as one of the most frequent cancers in women, is rapidly increasing, particularly in low‐ and middle‐income nations. , The cluster of differentiation 44 or CD44, as a tumor‐associated marker, can be used to detect breast cancer stem cells (BCSCs). Normal epithelial cells express CD44, w...
Metabolomics in oncology
0c49f6b9-497b-48d3-b88c-2e7a2de090cd
10026298
Internal Medicine[mh]
INTRODUCTION Metabolomics includes the systematic identification and quantification of metabolic products from the human body. In this review, we emphasize its relevance and potential applications in the oncology field. Cancer is one of the leading causes of mortality worldwide and a key deterrent to increasing global ...
Pharmacogenetics of
a5c5e4d3-2774-49cc-be78-b56c3f063892
10026301
Pharmacology[mh]
INTRODUCTION Acute myeloid leukemia (AML) comprises a heterogenous group of diseases with dismal outcomes mainly in developing countries. Identification of genetic alterations is key for risk stratification, as it guides to appropriate treatment. Most patients with AML are classified as intermediate or unfavorable risk...
Knowledge, Judgment, and Skills in Reproductive Health Care and Abortion Are Essential to the Practice of Obstetrics and Gynecology
359f4780-111d-42d6-8307-caab1fa58b33
10026965
Gynaecology[mh]
Using Test Question Templates to teach physiology core concepts
4303292e-9928-48b7-b76e-d53a372f1417
10026985
Physiology[mh]
Your undergraduate physiology students are starting a midterm exam. The first question is this: “How is the control of plasma glucose levels similar to the control of plasma calcium levels?” You are eager to see how students respond, since when you covered these two examples of homeostasis in lecture you were careful t...
A paradigm for fostering patient-centered research in liver disease: The liver transplant patient-engagement program
f5e092c6-3ea9-4ff9-9fbe-c3fb99c9c06c
10027036
Patient-Centered Care[mh]
As metrics for high-quality care encompass more than just clinical endpoints, it is increasingly important to incorporate patient perspectives into research efforts. In the past decade, patient engagement has become a major cornerstone of research endeavors for funding agencies such as The Patient-centered Outcomes Res...
The future of
a5792e82-c956-4d9d-a24f-20f56721b9ea
10027037
Internal Medicine[mh]
Hepatology Communications is home for all researchers invested in advancing their knowledge of liver disease. As such the journal will be led by co-EiC as partners capable of bridging varied forms of expertise in basic, translational, and clinical science that enrich our research community. Dr Carmen Wong is a basic sc...
Microfocus computed tomography for fetal postmortem imaging: an overview
a92eba54-e41b-461b-92b6-b0422d06e996
10027643
Forensic Medicine[mh]
Fetal autopsy is the modality of choice for diagnosing causes of stillbirth and intrauterine fetal demise (IUFD) and for confirming congenital anomalies. It offers clinically significant findings in approximately 40–70% of cases . Knowing the cause of their loss provides consolation for bereaved parents and offers impo...
Family physicians' involvement in palliative cancer care
fbd081e1-b096-41df-944e-226472ea74e9
10028020
Internal Medicine[mh]
INTRODUCTION Early outpatient palliative care improves quality of life, symptom control, and satisfaction with care for patients with advanced cancer. , , While clinical trials of early palliative care have predominantly examined specialized palliative care interventions, it is increasingly recognized that a sustainabl...
Mobile application to support oncology patients during treatment on patient outcomes: Evidence from a randomized controlled trial
0fb5a939-9565-4c3d-b457-b2d407bf29d0
10028030
Internal Medicine[mh]
INTRODUCTION Cancer treatments, especially chemotherapy, often require substantial demands on patients and their informal caregivers, including managing an overwhelming amount of information to coordinate treatment and related activities. Comprehensive coordinating efforts are needed to manage chemotherapy treatments t...
Application of NGS molecular classification in the diagnosis of endometrial carcinoma: A supplement to traditional pathological diagnosis
c5f69f88-7306-4e4a-a7df-efa0a8838834
10028062
Anatomy[mh]
INTRODUCTION Endometrial cancer (EC) is the most common gynecologic malignancy in China, with an increasing number of new diagnoses and a rapid mortality rate, which takes a heavy toll on women's health. , , The risk factors for EC include an excess of endogenous and exogenous estrogens, obesity, and others, and these ...
Cancer treatments touch a wide range of values that count for patients and other stakeholders: What are the implications for decision‐making?
d921e7ce-3567-4911-beb8-8676768289d2
10028089
Internal Medicine[mh]
INTRODUCTION The worldwide cancer rate is expected to increase from 19 million in 2020 to 30 million in 2040. Costs of cancer care are high and continue to rise. In Europe, costs have almost doubled from €52 billion in 1995 to €103 billion in 2018. Over the years, patient‐centred care is gaining increasing interest in ...
Early Termination of Oncology Clinical Trials in the United States
6f287b46-f9cc-47a5-8d30-4d3c86e9e54b
10028157
Internal Medicine[mh]
INTRODUCTION Interventional clinical trials play a vital role in advancing new therapeutic approaches in medicine. Prior work has shown that a significant portion of clinical trials are terminated early. , Early termination can happen due to reasons that include, but are not limited to, poor accrual, funding issues, an...
Study of nonsynchronous online teaching of regional anatomy for international students integrated with medical humanities and local culture during COVID-19 pandemic
a462486b-c015-4cb5-baf8-e0b76008e993
10028764
Anatomy[mh]
Regional anatomy is a core course of basic medicine and a bridge discipline between basic medicine and clinical medicine. Regional anatomy is taught to the first- and second-year medical students through didactic lectures and corpse dissection. The COVID-19 pandemic imposed unexpected disruptions to anatomical educatio...
Analyses of human papillomavirus,
806e3c8f-6fa9-4e3b-9ab6-2eba56c14818
10029165
Gynaecology[mh]
Sexually transmitted infections (STIs) are a major source of morbidity globally in both men and women. The use of Pap smears and human papillomavirus (HPV) testing has led to an increase in the detection of cervical dysplasia and a decrease in the incidence of cervical cancer. Mobile health programs enhance cancer scre...
Population Pharmacokinetics, Pharmacogenomics, and Adverse Events of Osimertinib and its Two Active Metabolites, AZ5104 and AZ7550, in Japanese Patients with Advanced Non-small Cell Lung Cancer: a Prospective Observational Study
829fb4d8-085c-410d-855c-2d8b59183a45
10030409
Pharmacology[mh]
Osimertinib, a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), is a first-line treatment for patients with advanced EGFR-positive non-small cell lung cancer (NSCLC) . It has an excellent efficacy and safety profile; however, over 80% and 30% of patients administered osimertinib...
The roles of social norms and leadership in health communication in the context of COVID-19
4f8eb694-2c5a-48fc-b4e6-386dbd6f37aa
10030439
Health Communication[mh]
The roles of the leaders in health communication In crises that bring uncertainty and threats, people seek guidance from their leaders . Pandemics are highly stressful events in which individuals must confront uncertain and ambiguous situations . In the context of COVID-19, which has not only been a long-lasting threat...
Claude Bernard and life in the laboratory
0b647371-64cc-4e63-aa02-e6d9ca16b27f
10030445
Physiology[mh]
Physiological laboratories properly speaking are an invention of the second half of the nineteenth century. They became only gradually established along with the process of the institutional separation of physiology from anatomy that European universities underwent in the second third of that century (Schiller, ). In h...
Can we design the next generation of digital health communication programs by leveraging the power of artificial intelligence to segment target audiences, bolster impact and deliver differentiated services? A machine learning analysis of survey data from rural India
ce338d47-3d5f-4fb2-a35b-69ad60012d1c
10030469
Health Communication[mh]
Digital health solutions have the potential to address critical gaps in information access and service delivery, which underpin high mortality. Mobile health communication programmes, which provide information directly to beneficiaries, are among the few examples of digital health solutions to have scaled widely in a r...
Thermal acclimation of methanotrophs from the genus
f08574f0-a6f2-41ea-9132-47d4fdba1df4
10030640
Microbiology[mh]
The only known biological CH 4 sink are methanotrophs that utilize CH 4 as an energy and carbon source . Aerobic methanotrophs belong to Gammaproteobacteria, Alphaproteobacteria, and Verrucomicrobia. These bacteria are found in soils, wetlands, water, rice paddies, landfills, sewage, and sediments, consuming subsurface...
Life history strategies among soil bacteria—dichotomy for few, continuum for many
7637dd7f-4f0a-473e-9b4e-49ea116e659f
10030646
Microbiology[mh]
The concept of copiotrophy and oligotrophy in microbial communities offers the potential for an organizing principle to describe the complexity of microbial systems. As such, it has been discussed for decades in relation to marine environments and soils . The framework is a direct descendent of r-K selection theory, w...
Correlations between care users’ and the healthcare inspectorate’s ratings of the quality of care in long-term care homes
96428199-77c9-4b56-90d4-e75a3686aa58
10030658
Patient-Centered Care[mh]
Healthcare inspectorates value the importance of care users’ experiences of the quality of care provided in long-term care (LTC) homes, however, they struggle to address these experiences in regulatory practice. Earlier studies showed weak to low-to-medium positive correlations between care users’ and inspectorates’ ra...
Novel patient-centred outcome in cancer care, days at home: a scoping review protocol
02fcc239-1655-4156-ae9a-a455544c1912
10030791
Patient-Centered Care[mh]
Patient-centred care is important and desired by patients and providers. It is a holistic approach to healthcare that seeks to treat patients as unique individuals by incorporating patient and family values, perspectives and expectations into a shared decision-making model. Patient-centred care was initially introduced...
Diversity and bioactive potential of
e019c2bb-7678-476a-bdd2-97e31941d99d
10031196
Microbiology[mh]
Natural products play a key role in drug discovery, especially when it comes to the treatment of infectious diseases and cancers (Newman and Cragg ). However, the rapid spread of bacterial infections has been observed in recent decades, mainly due to the rapid emergence and spread of multidrug-resistant (MDR) pathogens...
Management of wounds with exposed bone structures using an induced‐membrane followed by polymethyl methacrylate and second‐stage skin grafting in the elderly with a 3‐year follow‐up
4ae4747c-6c12-4d61-ab13-3b4ce37d93e0
10031252
Debridement[mh]
INTRODUCTION Victims of high‐speed vehicular accidents often present with large degloving injuries, compound fractures and severe damage to soft tissues. , These wounds are frequently left open and require repeated debridement, resulting in large soft‐tissue defects. Traumatic wounds with exposed bone or tendon heal po...
Medical Residents, the Group and the Formation of Professional Identity During the COVID-19 Pandemic
eb87d865-eade-450e-9b12-39d57686857d
10032050
Gynaecology[mh]
Due to the growing complexity of health care, physician training has been modified to include the skills necessary for new and constantly changing scenarios. The coronavirus disease 2019 (COVID-19) pandemic represents one of the most important health crises in recent human history. In medical education, these changes h...
Histopathology and SARS-CoV-2 Cellular Localization in Eye Tissues of COVID-19 Autopsies
44b81d33-136a-4ba2-a5b8-757f5549a46d
10032059
Forensic Medicine[mh]
Postmortem Human Eye Procurement and Processing Postmortem human eyes (E1 to E25) from 25 patients with confirmed SARS-CoV-2 infection were obtained at autopsy performed at the NIH Clinical Center following consent of the legal next of kin as previously described. The study adhered to the tenets of the Declaration of H...
Occupational risks to pregnant obstetrics and gynaecology trainees and physicians: Is it time to think about this?
85fd8e88-1176-40a9-a0af-f9c63992908e
10032316
Gynaecology[mh]
The proportion of women in the workforce has been steadily increasing worldwide. Women now constitute approximately 75% of the global health care workforce and almost 90% in nursing and midwifery professions . In India, females form 38% of all health care workers (HCW) and about 16.8% of allopathic doctors. Roughly 1 ...
Human scent signature on cartridge case survives gun being fired: A preliminary study on a potential of scent residues as an identification tool
5023c69a-9f4a-40d9-83fa-7cb2e3c5f0c7
10032514
Forensic Medicine[mh]
Nowadays, standard forensic procedures regarding firearms and crime scenes involve finding and securing fingerprints, gunshot residues, and scent traces. Specifically, human scent traces, if secured from a gun handle or gun slide on the crime scene, are generally compared by specially trained dogs . The ability of trai...
Reporting of measures of accuracy in systematic reviews of diagnostic literature
2500e913-c41d-420b-95b9-940dd12a8c04
100326
Pathology[mh]
The manner in which accuracy of clinical tests is mathematically summarised in the biomedical literature has important implications for clinicians. Appropriate accuracy measures would be expected to sensibly convey the meaning of the study results with scientifically robust statistics without exaggerating or underestim...
Pharmacogenetic profiling via genome sequencing in children with medical complexity
15b74f82-b867-4ef1-9424-f9b10db44ffb
10033400
Pharmacology[mh]
Children with medical complexity (CMC) are a well-studied, clinically defined group in pediatrics. – They typically have at least one severe chronic condition, technology dependence, multiple subspecialist involvement, and extensive care coordination needs. Polypharmacy is common in CMC – and was recently identified as...
null
f98c0286-86f0-485d-b948-dc78b53f72bc
10033568
Microbiology[mh]
Legionella are Gram-negative bacteria that can be found in natural (Atkinson et al., ; Zhan et al., ) and artificial aquatic environments (Prussin et al., ; Volker et al., ). The genus includes 64 species and more than 70 different serogroups (LPSN, ). Legionella are responsible for legionellosis, an infectious disease...
Risk management patterns in radiation oncology—results of a national survey within the framework of the Patient Safety in German Radiation Oncology (PaSaGeRO) project
fa316d21-aaac-449e-a6d6-af3b87da1f81
10033570
Internal Medicine[mh]
Radiation oncology (RO) plays a vital role in cancer management with almost half of all patients undergoing radiation therapy (RT) during their course of disease . Modern RT techniques complement patient-individualized treatment planning and image-guided dose delivery by adaptive radiation therapy from daily imaging an...
Large scale crowdsourced radiotherapy segmentations across a variety of cancer anatomic sites
00331ec6-e91d-443d-aa92-dc4ad12b62b9
10033824
Internal Medicine[mh]
Since the advent of contemporary radiation delivery techniques for cancer treatment, clinician generated segmentation (also termed contouring or delineation) of target structures (e.g., primary tumors and metastatic lymph nodes) and organs at risk (e.g., healthy tissues whose irradiation could lead to damage and/or sid...
Predicting outcomes in chronic kidney disease: needs and preferences of patients and nephrologists
2b967d47-c63e-4983-8e1b-1df39818956f
10035227
Internal Medicine[mh]
The course of chronic kidney disease (CKD) and the risk of progression to end-stage kidney disease (ESKD) vary among patients . Guidelines recommend that nephrologists use clinical prediction models (CPMs) to help identify patients at increased risk of CKD progression and adjust their treatment to help limit further ki...
Diversity of bacterial community in the rhizosphere and bulk soil of
5048523c-a147-4844-8a92-eb059089346c
10035820
Microbiology[mh]
Artemisia annua is widely grown in different parts of the world as a cheap source of the antimalarial compounds such as artemisinin, flavonoids, aromatic oils and polysaccharides . In Uganda, A . annua was introduced around 2003 and is mainly grown in Wakiso, Kaberamaido, Kapchorwa, Rukungiri, Kabarole and Kabale dist...
Pharmacy students’ attitudes and intentions of pursuing postgraduate studies and training in pharmacogenomics and personalised medicine
fce8bcf5-b3e7-46b6-9594-d31448809d86
10035981
Pharmacology[mh]
Personalised medicine (PM) and especially pharmacogenomics (PGx), are gaining momentum worldwide. PM constitutes a state-of-the-art approach able to revolutionise the way current medicine works . PGx is in the forefront of PM initiative, proposing an alternative treatment strategy in which individuals’ therapy scheme i...
Investigation of the effect of music listened to by patients with moderate dental anxiety during restoration of posterior occlusal dental caries
5e70d880-7874-419b-b4af-c4f98bf12b1f
10036243
Dental[mh]
Dental anxiety is excessive fear created by the thought of visiting the dentist for dental treatments . Factors such as the patient’s age, gender, educational level, profession, previous experiences, socio-economic status, and geography may each play a role in its etiology . Although there have been many innovations an...
A comparative analysis of human and AI performance in forensic estimation of physical attributes
0164229c-5e2b-4fcc-ac5c-939d68bad121
10036317
Forensic Medicine[mh]
Despite recent advances in artificial intelligence (AI) promising to revolutionise automated decision making, concerns are now being raised regarding fairness and efficacy across a range of high-impact fields, including the criminal justice system. The increasing use of algorithms in incarceration and rehabilitation ha...
Concordance of immunohistochemistry for predictive and prognostic factors in breast cancer between biopsy and surgical excision: a single-centre experience and review of the literature
ace62b9f-2e48-498c-b367-2024766345fe
10036406
Anatomy[mh]
Assessment of breast cancer biomarkers has become a staple of routine histopathology for every colleague working in this field. Assessment and quantification of oestrogen receptor (ER), progesterone receptor (PR), and c-erbB2/HER2 are used daily by the clinicians making fundamental therapeutic choices for the patients....
Aetiology of long bone chronic osteomyelitis: an analysis of the current situation in one region in Egypt
cf89960a-bd06-4372-bde6-0133b0cce164
10036446
Debridement[mh]
Osteomyelitis is characterized by low-grade inflammation caused by persistent pathogenic microorganisms with bone destruction and necrosis. It is still one of the most challenging conditions due to its long course, complex treatment, and risk of recurrence . Chronic osteomyelitis is intensely challenging to treat due t...
A realized facilitation cascade mediated by biological soil crusts in a sagebrush steppe community
3f5a26d0-1ab8-4b1e-bcee-ba6bc1a3087d
10036522
Microbiology[mh]
Biological soil crusts cover much of the soil surface in the arid and semi-arid regions of the world and have been described an “organizing principle” – . Soil crusts are highly variable and can be composed of nitrogen-fixing cyanobacteria and cyanolichens, lichens associated with green algae, free-living green algae a...
The usefulness of immunohistochemistry for phosphohistone H3 as a prognostic factor in myxoid liposarcoma
b5907aff-af6f-4ea6-9821-a59ed948627d
10036607
Anatomy[mh]
Soft tissue sarcoma (STS) is a rare malignant neoplasm that accounts for approximately 1% of all malignancies. Larger, deep-seated, and histological high-grade tumors are associated with poor survival. In addition, specific prognostic factors for some subtypes of STS are documented in the literature , . For instance, o...
Indian consensus statements on irritable bowel syndrome in adults: A guideline by the Indian Neurogastroenterology and Motility Association and jointly supported by the Indian Society of Gastroenterology
0620ee6f-1adf-4ec7-a744-6d6b6b8826da
10036984
Internal Medicine[mh]
Irritable bowel syndrome (IBS) is a common condition, which leads to significant morbidity, work absenteeism, loss of productivity, and economic burden to the society and impacts the quality of life of patients . There have been several recent developments in the understanding of pathophysiology, diagnosis and treatmen...
Diversity and Quantitative Detection of Clade I Type
87bcb68e-102e-4eab-a01d-21b68b1df1b8
10037096
Microbiology[mh]
Water sampling Water samples were collected from the ASTS location using Niskin bottles on a CTD rosette from the surface (5 m), deep chlo­rophyll maxima (DCM) (~43–50 m), core OMZ depths (250 and 500 m), and 1,000‍ ‍m during three seasons i.e. the Spring intermonsoon (SIM), Fall intermonsoon (FIM), and Northeast monso...
The opinions of GDPs on the challenges of managing tooth wear in primary dental care
f36a6ce7-e081-4361-b599-994f30ea2bb8
10037362
Dental[mh]
Three general dental practitioners (GDPs), each with over 20 years' experience in a variety of healthcare settings, but predominantly in general dental practice, were interviewed about their opinions of how patients with tooth wear are managed in primary care. The interviewees were included on the basis that they worke...
Integrated Small Animal PET/CT/RT with Onboard PET/CT Image Guidance for Preclinical Radiation Oncology Research
b6af1d60-e9a7-4b17-a753-c674110b459b
10037572
Internal Medicine[mh]
Combined PET/CT functional and anatomic images are ubiquitously used in clinical radiotherapy (RT) for tumor diagnosis and delineation to guide the treatment plan and access the therapeutic effects. However, in the field of preclinical radiation research, all existing image-guided small animal irradiator systems are on...
Comparative Study of Postmortem Concentrations of Benzodiazepines and Z-Hypnotics in Several Different Matrices
d08413ec-ca4b-4aa6-a63f-3beba8e227a9
10037634
Forensic Medicine[mh]
Toxicological analyses are important in forensic autopsy cases. Several matrices can be utilized. Peripheral blood (PB) is, however, considered to be the gold standard in these cases ( ) as concentrations measured in blood can indicate impairment or intoxication. In special cases where the body has a high degree of aut...
Mitral valve infective endocarditis in a dialysis patient with a tunneled dialysis catheter and prior MitraClip® implantation: an autopsy case
1590b616-aa3d-462a-a942-7b8efec68575
10037769
Forensic Medicine[mh]
Cardiac device-related infective endocarditis (CDRIE) is an infection that has spread to the endocardium, including device leads and heart valves . The main routes of device infection are device pocket infection during implantation surgery and exposure of the lead or catheter to skin surfaces. CDRIE occurs when inflamm...
A health communication campaign for prevention of osteoporosis in rural elderly women
6f71230d-5fbb-4798-8ace-36c20136a06d
10037817
Health Communication[mh]
Nowadays, osteoporosis, is an important global public health problem. It is usually asymptomatic and often presents as a clinically evident fracture, so it may impose an increasing physical and economic burden on patients and the society . Osteoporosis is a skeletal system disease characterized by low bone mass and str...
Suture-tape augmentation of anterior cruciate ligament reconstruction: a prospective, randomised controlled trial (STACLR)
c856e540-c2fb-4b2f-9815-2774ca8fa60f
10037835
Suturing[mh]
Note: the numbers in curly brackets in this protocol refer to SPIRIT checklist item numbers. The order of the items has been modified to group similar items (see http://www.equator-network.org/reporting-guidelines/spirit-2013-statement-defining-standard-protocol-items-for-clinical-trials/ ). Background and rationale ...
Assessment of the underlying causes of adult deaths using a short version of verbal autopsy in Xaiyabouli Province, Lao People’s Democratic Republic
2dd1c5fe-4802-4587-8848-1bcfec690ebd
10037893
Forensic Medicine[mh]
Information of deaths, such as the number of deaths, sex and age of the deceased persons, and causes of death, are essential information for policymakers and government officers to develop health policies and to implement appropriate interventions for improving public health in each country [ – ]. In most developed cou...
Medical students’ perceptions towards distance e-Learning in gynecology ward during the COVID-19 pandemic
7251ce39-76d3-46fe-854d-a287130c0907
10038303
Gynaecology[mh]
The coronavirus disease 2019 (COVID-19) pandemic has caused serious public health problems and compromised the health of individuals and communities . The spread of the COVID-19 virus across the world has affected the educational systems worldwide, including in Iran. The closure of educational institutions have created...
Improved rock phosphate dissolution from organic acids is driven by nitrate assimilation of bacteria isolated from nitrate and CaCO
2a8073e4-2b5b-404d-a977-6b087bb5b404
10038309
Microbiology[mh]
Phosphorus (P) is essential for life and is one of the key macro-nutrients for plant growth and development, including photosynthesis, energy transfers and nutrient uptake in plants [ – ]. Although organic and inorganic P forms are abundant in soils, they are highly insoluble (95–99%) with little mobility and low avail...
Perspectives of family medicine residents in Riyadh on leadership training: a cross-sectional study
02002e06-b5bd-40fd-a73c-e441ff1b6229
10038693
Family Medicine[mh]
As the recent coronavirus pandemic shows, health security is a critical aspect in developing countries and the world. Thus, many countries were eager to consider a substantial overhaul in the health care system. Saudi Arabia's policy has heavily emphasized primary care and called on family physicians to assume various ...
A population-based nomogram to individualize treatment modality for pancreatic cancer patients underlying surgery
7bbd155e-17aa-4f14-bec4-44dcb1ce579c
10038997
Internal Medicine[mh]
As one of the most aggressive and highly metastatic malignancies, pancreatic cancer ranks seventh among cancer-related deaths . Surgical resection with adjuvant/neoadjuvant therapy offers hope for long-term survival or cure in patients with non-metastatic pancreatic cancer . Local recurrence and metastasis of pancreati...
Sleep fMRI with simultaneous electrophysiology at 9.4 T in male mice
98396461-8ba7-411b-900c-3cf4fb89775e
10039056
Physiology[mh]
Sleep is generally considered a tightly regulated whole-brain phenomenon, and its role for our cognition and heath is, from our own daily experience, of great significance. In recent years, studies have identified neural circuits regulating transition and stability of awake-sleep cycle , . The ascending arousal system ...
Gender and Racial Representation Trends Among Internal Medicine Department Chairs from 2010–2020
fe8dd44c-c051-4b85-8f12-951c7b7e1655
10039186
Internal Medicine[mh]
Quality medical education, reduction in health disparities, and healthcare research that includes all members of society are enhanced by diversity in departments of internal medicine (IM). , , , As the largest subspecialty in medicine, IM trains the largest number of medical students and postgraduate trainees and produ...
Study on the effectiveness and safety of ciprofol in anesthesia in gynecological day surgery: a randomized double-blind controlled study
b31438ad-057a-42ea-a7a4-0bfab92d2e3a
10039513
Gynaecology[mh]
Day surgery has become popular in different countries because of its advantages in reducing hospitalization time, improving bed utilization and reducing hospitalization costs. With the development of medical technology, the proportion of day surgery is growing rapidly. Guidelines from the Association of Anaesthetists a...
The epidemiological and medico-legal characteristics of violent deaths and spousal homicides through a population of women autopsied within the Forensic Medicine Department of the University Hospital of Annaba
5814cf1c-2934-4d79-bb9f-293f17129931
10039587
Forensic Medicine[mh]
The mortality of women, and more particularly that which occurs as a result of domestic violence, represents a real public health problem with lethal consequences. The international literature on spousal homicide is poor and the references are limited. Nevertheless, some studies have attempted to draw up the profile of...
The experience of caregivers providing therapeutic patient education for people living with bipolar disorder: a qualitative study
69c86e66-273a-4d04-b8be-bde093546410
10039597
Patient Education as Topic[mh]
The caregivers interviewed who lead therapeutic education groups described a change in their caregiving posture, which was more horizontal and collaborative. Therapeutic education thus fostered empowerment and destigmatization, promoting patients appeasement and openness. The observations overlap with personal recovery...
Aqueous habitats and carbon inputs shape the microscale geography and interaction ranges of soil bacteria
bef66680-c091-4c02-9509-8569549c524a
10039866
Microbiology[mh]
The focus on large-scale biogeographic patterns – has revealed important drivers for soil microbial abundance , and diversity , . Soil bacteria rank high in the global biomass distribution and provide crucial ecosystem functions , , . Interactions between soil properties, precipitation , temperature, and associated fac...
The effect of hyperbaric oxygen therapy on the clinical outcomes of necrotizing soft tissue infections: a systematic review and meta-analysis
28019839-14ff-4e28-a944-42a239812351
10040118
Debridement[mh]
Necrotizing soft tissue infections (NSTI), also known as necrotizing fasciitis (NF), are a rare but serious type of infection that can rapidly progress and lead to life-threatening consequences if not promptly and aggressively treated [ – ]. NSTI can be secondary to any skin injury or blood-borne transmission, such as ...
Editorial: Rising stars in cardiovascular endocrinology 2022
d9bb4ff7-ebf7-4708-89c0-54c047cf70fc
10042285
Physiology[mh]
The author confirms being the sole contributor of this work and has approved it for publication.
Value of the clinical pharmacist interventions in the application of the American College of Cardiology (ACC/AHA) 2018 guideline for cholesterol management
2d071e88-bf5f-4e61-a809-cb71a6121cfd
10042341
Internal Medicine[mh]
Coronary heart disease (CHD) is considered one of the main causes of morbidity and mortality worldwide. One of the major risk factors that contributes to the development and progression of CHD is dyslipidemia . According to the World Health Organization (WHO), an estimated 17.9 million patients died each year because o...
Evaluation of a tool to improve the quality of preceptor written feedback for family medicine residents: training and use of a CanMEDS-MF competency-based criterion guide
7a01c8dd-448d-4dff-8788-6be2f022e76a
10042787
Family Medicine[mh]
Written feedback is an essential element in teaching residents, but preceptors are not always equipped to provide relevant feedback. Family medicine residency programs are aligned with a CanMEDS-Family Medicine (CanMEDS-FM) 2017 seven-competency framework to address patient needs, developed by the College of Family Phy...
Soil contamination in nearby natural areas mirrors that in urban greenspaces worldwide
ffcc3821-9f0c-4e9a-816c-d53c57aff37d
10042830
Microbiology[mh]
Soil contamination challenges many of the United Nations Sustainable Development Goals such as good health and wellbeing, sustainable ecosystems and cities, and climate change regulation , . Environmental stress associated with soil contamination, either from natural or anthropogenic origins, can directly affect biodiv...
A neurophysiological perspective on the integration between incidental learning and cognitive control
d73a0b01-3523-4583-b83b-14eb5b90c9fd
10042851
Physiology[mh]
Changing the course of action to meet our goal requires effort, therefore, it is paramount to recognise when it is necessary to do so – . A collection of functions, often labelled as cognitive control, can be recruited to meet one’s goal , . For instance, when stimulus properties trigger incompatible stimulus-response ...
Nocardia infection following ocular surface surgery
a70e8c0c-2f02-4013-9529-87fe50e03f2d
10042929
Ophthalmology[mh]
Nocardia is a gram-positive, weakly acid-fast, filamentous bacteria that can cause various ocular infections, such as keratitis, scleritis, and endophthalmitis . Ocular nocardiosis, though has been increasingly reported in recent years, is rarely diagnosed in most parts of the world because of its infrequent occurrence...
Deletion of
f1b96c1c-2486-492e-9a38-c22eb23faaa9
10043021
Microbiology[mh]
Bioethanol is the biofuel most used worldwide in the transportation sector, its production having increased regularly since the early nineties . In 2020, the USA and Brazil accounted, respectively, for 53% and 30% of global biofuel production . Bioethanol is produced from a wide variety of renewable resources (feedstoc...
Standardization in hematology and wine
7a25fa50-7514-4d0a-ba5a-6dab398749dd
10043520
Internal Medicine[mh]
Artificial intelligence-based text generators in hepatology: ChatGPT is just the beginning
b341f0f3-d9e2-4d95-9690-cbfb8695fbe6
10043591
Internal Medicine[mh]
In recent years, there has been growing interest in the use of artificial intelligence (AI) and machine learning techniques to aid in the study and treatment of liver diseases. One such AI tool that has garnered attention is ChatGPT, a variant of the GPT (Generative Pretraining Transformer) language model developed by ...
Multiple distant metastases arising from a single, low-grade rectal neuroendocrine tumor: an autopsy case report
32d252f8-4ee4-4952-b3f1-7797d2e3cdbf
10044367
Forensic Medicine[mh]
Neuroendocrine neoplasms (NENs) are rare epithelial neoplasms mostly occurring in the hypothalamus, parathyroid glands, lungs, pancreas, and gastrointestinal tract . Within the gastrointestinal tract, rectal NENs are the most common in Japan , with an incidence rate of 4.52 per 100,000 population . The incidence of rec...
Integrating health promotion with and for older people - eHealth (IHOPe) – evaluating remote integrated person-centred care
fc89f525-420d-489e-a19c-ab1d6b694bb4
10044387
Patient-Centered Care[mh]
By 2050, the number of people aged ≥ 75 years is expected to increase by 50% worldwide , which means an escalating global demand for diverse healthcare systems . Moreover, the number of people aged > 80 years is also increasing rapidly . Advanced age is often associated with increased risk of frailty, multi-morbidity, ...
Immunohistochemical visualization of lymphatic vessels in human dura mater: methodological perspectives
c3b347dc-f32a-47f8-a64e-c4eac47b78aa
10044429
Anatomy[mh]
The study of meningeal lymphatic vessels has a long history. In 1787, the Italian anatomist Giovanni Paolo Mascagni for the first time demonstrated lymphatic vessels within the human dura, which he described in a Latin text termed Vasorum Lymphaticorum Corporis Humani Historia et Ichnographia (English History and Graph...
Needs assessment for enhancing pediatric clerkship readiness
ed26f592-c3c0-42e4-9312-6f3b31e6ff78
10044806
Internal Medicine[mh]
Early clinical exposure and clinical skill development in medical school training is important for students to be successful during clerkships. Inadequate preparation may impact students’ ability to learn key skills, knowledge, and behaviors. A study examining clerkship directors’ views regarding pre-clerkship preparat...
Effect of interactive, multimedia-based home-initiated education on preoperative anxiety inchildren and their parents: a single-center randomized controlled trial
369582af-9802-4f6c-8a44-8632f207b8b3
10045252
Patient Education as Topic[mh]
Preoperative anxiety in pediatric patients usually begins at admission when they know that they would undergo a surgical operation . Up to 50–60% of children undergoing surgical procedures experience significant preoperative anxiety . An unpleasant surgical or anesthesia experience, younger age, short preoperative prep...
Canada’s First Joint Oncology-Allergy Clinic: Successful Desensitization to Trastuzumab Following Severe Anaphylactic Reaction in Which Epinephrine Was Inappropriately Withheld
b9b089e1-8991-44ee-9919-9748cbeb66f2
10046925
Internal Medicine[mh]
Trastuzumab is a humanized recombinant monoclonal antibody agent targeting the proto-oncogene human epidermal growth factor receptor 2 (HER2) . HER2 is overexpressed in approximately 20% of breast cancers . Neoadjuvant trastuzumab has been shown to increase pathologic complete response rates when combined with chemothe...
B7H4 Expression Is More Frequent in MSS Status Colorectal Cancer and Is Negatively Associated with Tumour Infiltrating Lymphocytes
f5b247a6-fbae-48bb-a35b-f1607df35c2f
10046962
Anatomy[mh]
The B7H4 (aliases VTCN1, B7S1, B7x) protein belongs to the B7 family . The B7 family ligands (present on APCs-Antigen presenting cells) bind to its counter receptor from the CD28 family (present on the T cell), which plays a central role in fine-tuning the antigen-specific immune response. This immune response belongs ...
Impact of the COVID-19 Pandemic on Medical Oncology Workload: A Provincial Review
f5a8a594-0e3f-42c2-9788-b6a4c0802209
10047010
Internal Medicine[mh]
Cancer is the leading cause of death in Canada, with increasing incidence and mortality . Almost half of Canadians will be diagnosed with cancer in their lifetime and incidence is projected to increase a further 79% by 2032 . Eastern and Central Canada are found to have the highest predicted incidence rates, with the s...
Variation in general practice referral rate to acute medicine services and association with hospital admission. A retrospective observational study
95087cde-ebf9-4653-a91f-ed134cbb69a7
10047615
Family Medicine[mh]
A small fraction of people seen in primary care each year are referred to hospital services for acute medical care. Acute medical assessment units are designed to provide urgent assessment and treatment for patients with potentially life-threatening conditions for whom primary care physicians (general practitioners) de...
Future of Artificial Intelligence Applications in Cancer Care: A Global Cross-Sectional Survey of Researchers
f571ddc1-3d47-4a6f-b24e-a599fb90f430
10047823
Internal Medicine[mh]
Cancer is one of the leading causes of death in every country globally . World Health Organization (WHO) data for the year 2022 show that cancer is the second leading cause of death among noncommunicable diseases, resulting in 9.3 million deaths per year, second only to cardiovascular diseases (17.9 million) . This pro...
Development of Improved DNA Collection and Extraction Methods for Handled Documents
bc60c03a-76f0-4435-8e4e-5bf83e3535eb
10048427
Forensic Medicine[mh]
Paper evidence may be recovered from a crime scene and is frequently encountered in forgery, aggravated harassment, and robbery investigations. Such evidence may be handwritten or typed, but likely contains DNA deposits due to handling. Individuals vary in the amount of DNA they deposit on a surface . Time since handwa...
Validation of Probabilistic Genotyping Software for Single Cell STR Analysis
6b2b376e-90d6-4832-a686-e85797f51890
10048617
Forensic Medicine[mh]
The application of single/few cell analysis to mixture deconvolution is a growing field in forensic DNA analysis. By analyzing many individual or few cell subsamples collected from a bulk complex DNA mixture, an increase in probative DNA information is often achieved compared to standard DNA mixture approaches (i.e., t...
An Investigation into Compound Likelihood Ratios for Forensic DNA Mixtures
6ee295ad-0a30-4504-aa11-cced877a0e6a
10048689
Forensic Medicine[mh]
When forensic DNA testing reveals a concordance between a crime scene sample and a person of interest’s (POI) DNA profile, it is necessary to provide a statistic to evaluate the strength of the correspondence or the weight of the evidence. The likelihood ratio ( LR ) is acknowledged as the most powerful and relevant st...
Responses of Soil Collembolans to Land Degradation in a Black Soil Region in China
a7585529-4be0-4b78-95ef-c5a296674102
10048822
Microbiology[mh]
Land degradation, a global issue affecting billions of people, is a phenomenon caused by a combination of natural forces and artificial activities . Erosion by wind or water, salination, deforestation, high farming intensity and the overuse of pesticides and fertilizers are the main causes of land degradation . Land de...
Co-Designing Communication: A Design Thinking Approach Applied to Radon Health Communication
1867b130-2254-4728-abef-226623c5e5e1
10048842
Health Communication[mh]
Health intervention planning models emphasize the importance of participatory methods, thus involving community members and other relevant stakeholders in the different planning stages, from problem definition to intervention implementation . Not only does this increase the external validity of the intervention by the ...
Predicting Fecal Indicator Bacteria Using Spatial Stream Network Models in A Mixed-Land-Use Suburban Watershed in New Jersey, USA
d69ec1e9-d4c4-41a2-9871-312ce61551c4
10049084
Microbiology[mh]
Good water quality ensures the well-being of urban and suburban residents, as it safeguards public health and provides economic benefits through recreational opportunities . However, microbial water quality is often impaired due to expanded impervious areas and the improper management of sanitary infrastructures, such ...
Transcriptomic Signatures of Single-Suture Craniosynostosis Phenotypes
e3ef8dc4-8322-4873-81e6-a148b8d5d5e3
10049207
Suturing[mh]
Craniosynostosis is the premature fusion of one or more of the calvarial sutures, that occurs in syndromic and non-syndromic forms in approximately 1 in 2100–2500 live births [ , , ]. The syndromic craniosynostoses are hereditary conditions, defined as having craniosynostosis associated with reproducible features invol...
Practices and Perceptions of Family-Centered Care: A Cross-Sectional Survey of Secondary School Athletic Trainers
1bcca3d0-5c66-4858-b8d8-7bef93513f10
10049324
Patient-Centered Care[mh]
Patient-centered care, which includes the healthcare provider being responsive to and respectful of the patient’s values and needs in their clinical care, has been widely studied across healthcare professions, specifically in athletic training . Athletic training is a healthcare profession that provides medical service...
Effects of Variation in
328855c6-00b9-4625-a728-4948acd92069
10049481
Microbiology[mh]
Floodplains, located in the transition zone between aquatic and terrestrial ecosystems, are characterized by high primary productivity and biological diversity . Due to the interference of climate change and human activities, floodplain ecosystem stability has been seriously disturbed, and this has resulted in soil ero...
Patient Education Improves Pain and Health-Related Quality of Life in Patients with Established Spinal Osteoporosis in Primary Care—A Pilot Study of Short- and Long-Term Effects
0b8d09be-3315-4f75-87a9-899fda958c82
10049553
Patient Education as Topic[mh]
Osteoporosis is defined as a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk . Fragility fractures, in specific vertebral and hip fractures, are associated with high morbidity, mo...
Opportunities and challenges in early diagnosis of rheumatoid arthritis in general practice
e4b42a53-aa67-4c1b-966f-238f3dfbb8d5
10049595
Family Medicine[mh]
Prompt diagnosis of rheumatoid arthritis (RA), the most common form of inflammatory arthritis, is crucial to optimise long-term patient outcomes through prevention of joint damage and disability. However, early disease can be challenging to identify in primary care, especially given that RA makes up a small proportion ...
Eptifibatide, an Older Therapeutic Peptide with New Indications: From Clinical Pharmacology to Everyday Clinical Practice
31412cb5-5974-4827-80df-21b92f49b87a
10049647
Pharmacology[mh]
Peptide-based therapies are an emerging class of medications . Following the rapid evolution of cutting-edge production, modification, and analytical technologies, peptide medication development has advanced significantly in recent years. These technological developments have helped to reduce the inherent limitations o...