text:
} {ATORVASTATIN} {INTO}
                 {MODEL} {MEMBRANES}",
  institution = "Warner-Lambert",
  month       =  mar,
  year        =  1996
}

@ARTICLE{Bays2003-iq,
  title    = "Effectiveness and tolerability of a new lipid-altering agent,
              gemcabene, in patients with low levels of high-density
              lipoprotein cholesterol",
  author   = "Bays, Harold E and McKenney, James M and Dujovne, Carlos A and
              Schrott, Helmut G and Zema, Michael J and Nyberg, Jack and
              MacDougall, Diane E",
  journal  = "Am. J. Cardiol.",
  volume   =  92,
  number   =  5,
  pages    = "538--543",
  month    =  sep,
  year     =  2003,
  address  = "Louisville Metabolic and Atherosclerosis Research Center,
              Louisville, Kentucky 40213, USA. HBaysMD@aol.com",
  language = "eng"
}

@ARTICLE{Paoletti2001-zt,
  title    = "Rosuvastatin demonstrates greater reduction of low-density
              lipoprotein cholesterol compared with pravastatin and simvastatin
              in hypercholesterolaemic patients: a randomized, double-blind
              study",
  author   = "Paoletti, R and Fahmy, M and Mahla, G and Mizan, J and
              Southworth, H",
  journal  = "J. Cardiovasc. Risk",
  volume   =  8,
  number   =  6,
  pages    = "383--390",
  month    =  dec,
  year     =  2001,
  address  = "Department of Pharmacological Sciences, University of Milan,
              Milan, Italy. rodolfo.paoletti@unimi.it",
  language = "eng"
}

@TECHREPORT{Knebel2009-mf,
  title       = "Population {PK} Modeling of {PF-04360365} in Adults with
                 {Mild-to-Moderate} Alzheimer's Disease",
  author      = "Knebel, W",
  institution = "Pfizer, Inc.",
  year        =  2009
}

@MISC{noauthor_2008-td,
  title = "Nicox Study Report {HCT} 3012-X-304: Pooled Blood Pressure Safety
           Analysis",
  year  =  2008
}

@ARTICLE{Peets1972-rx,
  title    = "Metabolism of chlorpheniramine maleate in man",
  author   = "Peets, E A and Jackson, M and Symchowicz, S",
  journal  = "J. Pharmacol. Exp. Ther.",
  volume   =  180,
  number   =  2,
  pages    = "364--374",
  month    =  feb,
  year     =  1972,
  language = "eng"
}

@INPROCEEDINGS{Dube1980-ym,
  title     = "Pharmacokineties of chlorpheniramine maleate in chronic renal
               failure: {E}ffect of hemodialysis and peritoneal dialysis",
  booktitle = "American Pharmaceutical Association 127th Annual Meeting",
  author    = "Dube, L M and Block, R and Warner, R N and Hyslop, R M and
               Popvichm, N G and Gonzales, M A",
  pages     = "84",
  year      =  1980,
  address   = "Washington D.C."
}

@ARTICLE{Arbesman1950-zl,
  title   = "Report of Committee on therapy",
  author  = "Arbesman, C E",
  journal = "J. Allergy",
  volume  =  21,
  pages   = "255--258",
  year    =  1950
}

@ARTICLE{Miller2008-mw,
  title    = "Effect of denosumab on bone density and turnover in
              postmenopausal women with low bone mass after long-term
              continued, discontinued, and restarting of therapy: a randomized
              blinded phase 2 clinical trial",
  author   = "Miller, Paul D and Bolognese, Michael A and Lewiecki, E Michael
              and McClung, Michael R and Ding, Beiying and Austin, Matthew and
              Liu, Yu and San Martin, Javier",
  journal  = "Bone",
  volume   =  43,
  number   =  2,
  pages    = "222--229",
  month    =  aug,
  year     =  2008,
  address  = "Colorado Center for Bone Research, 3190 South Wadsworth Blvd, Ste
              250, Lakewood, CO 80227, USA. millerccbr@aol.com",
  language = "eng"
}

@TECHREPORT{noauthor_2009-up,
  title       = "Validation Report History {LCMS} 214: {Q}uantitation of
                 {C}hlorpheniramine in Human Plasma via {HPLC} with {MS/MS}
                 Detection",
  institution = "PPD Development",
  month       =  feb,
  year        =  2009,
  address     = "2244 Dabney Road, Richmond, Virginia"
}

@TECHREPORT{noauthor_2002-tt,
  title       = "Validation Report {LCMS} 214: {Q}uantitation of
                 {C}hlorpheniramine in Human Plasma via {HPLC} with {MS/MS}
                 Detection. {Protocol No. {AR-00-02}}",
  institution = "PPD Development",
  month       =  apr,
  year        =  2002,
  address     = "2244 Dabney Road, Richmond, Virginia"
}

@TECHREPORT{noauthor_1998-pz,
  title       = "Validation Report: {GC} analysis of {C}hlorpheniramine in
                 human plasma",
  institution = "PPD Pharmaco, Inc.",
  month       =  sep,
  year        =  1998,
  address     = "2244 Dabney Road, Richmond, Virginia"
}

@TECHREPORT{Zinny_undated-uo,
  title       = "{Ibuprofen/Pseudoephedrine/Chlorpheniramine}. {Protocol
                 {AD-99-03}. {CSR-AD-99-03}}",
  author      = "Zinny, Miguel",
  institution = "Wyeth Consumer Healthcare",
  address     = "Madison, NJ"
}

@TECHREPORT{Dawkins_undated-hl,
  title       = "Pharmacokinetic Report {AR-00-02}",
  author      = "Dawkins, Ray",
  institution = "Wyeth Consumer Healthcare",
  address     = "Madison, NJ"
}

@TECHREPORT{noauthor_undated-ya,
  title       = "Pharmacokinetic Report {AR-00-03}",
  institution = "Wyeth Consumer Healthcare",
  address     = "Madison, NJ"
}

@TECHREPORT{Laurent_undated-gk,
  title       = "{Ibuprofen/Phenylephrine/Chlorpheniramine} {{CSR} {AD-05-05}}",
  author      = "Laurent, Aziz",
  institution = "Wyeth Consumer Healthcare",
  address     = "Madison, NJ"
}

@ARTICLE{Peterson2010-zc,
  title   = "A physiologically based mathematical model of integrated calcium
             homeostasis and bone remodeling",
  author  = "Peterson, Mark C and Riggs, Matthew M",
  journal = "Bone",
  volume  =  46,
  pages   = "49--63",
  month   =  jan,
  year    =  2010
}

@ARTICLE{Yang1996-xn,
  title   = "Estrogen and raloxifene stimulate transforming growth factor-beta
             3 gene expression in rat bone: a potential mechanism for estrogen-
             or raloxifene-mediated bone maintenance",
  author  = "Yang, N N and Bryant, H U and Hardikar, S and Sato, M and Galvin,
             R J and Glasebrook, A L and Termine, J D",
  journal = "Endocrinology",
  volume  =  137,
  number  =  5,
  pages   = "2075--2084",
  month   =  may,
  year    =  1996
}

@ARTICLE{Spelsberg1999-ew,
  title   = "The actions and interactions of sex steroids and growth
             factors/cytokines on the skeleton",
  author  = "Spelsberg, T C and Subramaniam, M and Riggs, B L and Khosla, S",
  journal = "Mol. Endocrinol.",
  volume  =  13,
  number  =  6,
  pages   = "819--828",
  month   =  jun,
  year    =  1999
}

@ARTICLE{McCarthy2003-gg,
  title    = "Runx2 integrates estrogen activity in osteoblasts",
  author   = "McCarthy, Thomas L and Chang, Wei-Zhong and Liu, Yuan and
              Centrella, Michael",
  journal  = "J. Biol. Chem.",
  volume   =  278,
  number   =  44,
  pages    = "43121--43129",
  month    =  oct,
  year     =  2003,
  keywords = "Non-programmatic"
}

@ARTICLE{Hawse2008-nu,
  title   = "{Estrogen-TGFbeta} cross-talk in bone and other cell types: role
             of {TIEG}, Runx2, and other transcription factors",
  author  = "Hawse, J R and Subramaniam, M and Ingle, J N and Oursler, M J and
             Rajamannan, N M and Spelsberg, T C",
  journal = "J. Cell. Biochem.",
  volume  =  103,
  number  =  2,
  pages   = "383--392",
  month   =  feb,
  year    =  2008
}

@ARTICLE{Bone2000-lu,
  title   = "Alendronate and estrogen effects in postmenopausal women with low
             bone mineral density. {Alendronate/Estrogen} Study Group",
  author  = "Bone, H G and Greenspan, S L and McKeever, C and Bell, N and
             Davidson, M and Downs, R W and Emkey, R and Meunier, P J and
             Miller, S S and Mulloy, A L and Recker, R R and Weiss, S R and
             Heyden, N and Musliner, T and Suryawanshi, S and Yates, A J and
             Lombardi, A",
  journal = "J. Clin. Endocrinol. Metab.",
  volume  =  85,
  number  =  2,
  pages   = "720--726",
  month   =  feb,
  year    =  2000
}

@ARTICLE{Greenspan2002-pz,
  title   = "Significant differential effects of alendronate, estrogen, or
             combination therapy on the rate of bone loss after discontinuation
             of treatment of postmenopausal osteoporosis. A randomized,
             double-blind, placebo-controlled trial",
  author  = "Greenspan, Susan L and Emkey, Ronald D and Bone, Henry G and
             Weiss, Stuart R and Bell, Norman H and Downs, Robert W and
             McKeever, Clark and Miller, Sam S and Davidson, Michael and
             Bolognese, Michael A and Mulloy, Anthony L and Heyden, Norman and
             Wu, Mei and Kaur, Amarjot and Lombardi, Antonio",
  journal = "Ann. Intern. Med.",
  volume  =  137,
  number  =  11,
  pages   = "875--883",
  month   =  dec,
  year    =  2002
}

@ARTICLE{Peterson2007-sx,
  title   = "Calcium Homeostasis and Bone Remodeling: Development of an
             Integrated Model for Evaluation and Simulation of Therapeutic
             Responses to {Bone-Related} Therapies",
  author  = "Peterson, Mark C and Riggs, Matthew M",
  journal = "PAGE Abstracts of the Annual Meeting of the Population Approach
             Group in Europe 16",
  pages   = "Abstr 1218",
  year    =  2007
}

@ARTICLE{Peterson2007-bw,
  title   = "A Calcium Homeostasis Model for Simulation of Therapeutic
             Responses to {Bone-Related} Therapies",
  author  = "Peterson, Mark C and Riggs, Matthew M",
  journal = "AAPS J.",
  volume  = "9(S2)",
  pages   = "Abstr 3504",
  year    =  2007
}

@ARTICLE{Khosla2007-yb,
  title   = "Estrogen and the death of osteoclasts: {A} fascinating story",
  author  = "Khosla, S",
  journal = "Bonekey Osteovision",
  volume  =  4,
  number  =  10,
  pages   = "267--272",
  year    =  2007
}

@ARTICLE{Savic2009-ba,
  title   = "Importance of Shrinkage in Empirical Bayes Estimates for
             Diagnostics: Problems and Solutions",
  author  = "Savic, Radojka M and Karlsson, Mats O",
  journal = "AAPS J.",
  month   =  aug,
  year    =  2009
}

@ARTICLE{Barrett2008-zx,
  title   = "Pharmacometrics: a multidisciplinary field to facilitate critical
             thinking in drug development and translational research settings",
  author  = "Barrett, Jeffrey S and Fossler, Michael J and Cadieu, K David and
             Gastonguay, Marc R",
  journal = "J. Clin. Pharmacol.",
  volume  =  48,
  number  =  5,
  pages   = "632--649",
  month   =  may,
  year    =  2008
}

@ARTICLE{Wang2009-ml,
  title   = "Elucidation of relationship between tumor size and survival in
             non-small-cell lung cancer patients can aid early decision making
             in clinical drug development",
  author  = "Wang, Y and Sung, C and Dartois, C and Ramchandani, R and Booth, B
             P and Rock, E and Gobburu, J",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  86,
  number  =  2,
  pages   = "167--174",
  month   =  aug,
  year    =  2009
}

@ARTICLE{Mehta2009-cr,
  title   = "Optimizing trial design: sequential, adaptive, and enrichment
             strategies",
  author  = "Mehta, Cyrus and Gao, Ping and Bhatt, Deepak L and Harrington,
             Robert A and Skerjanec, Simona and Ware, James H",
  journal = "Circulation",
  volume  =  119,
  number  =  4,
  pages   = "597--605",
  month   =  feb,
  year    =  2009
}

@ARTICLE{Gibiansky2009-su,
  title   = "Target-mediated drug disposition model: relationships with
             indirect response models and application to population {PK-PD}
             analysis",
  author  = "Gibiansky, Leonid and Gibiansky, Ekaterina",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  36,
  number  =  4,
  pages   = "341--351",
  month   =  aug,
  year    =  2009
}

@ARTICLE{Lunn2009-yf,
  title   = "The {BUGS} project: Evolution, critique and future directions",
  author  = "Lunn, David and Spiegelhalter, David and Thomas, Andrew and Best,
             Nicky",
  journal = "Stat. Med.",
  month   =  jul,
  year    =  2009
}

@ARTICLE{Bauer1999-dk,
  title   = "Combining different phases in the development of medical
             treatments within a single trial",
  author  = "Bauer, P and Kieser, M",
  journal = "Stat. Med.",
  volume  =  18,
  number  =  14,
  pages   = "1833--1848",
  month   =  jul,
  year    =  1999
}

@ARTICLE{Bretz2006-gp,
  title   = "Confirmatory seamless phase {II/III} clinical trials with
             hypotheses selection at interim: general concepts",
  author  = "Bretz, Frank and Schmidli, Heinz and K{\"o}nig, Franz and Racine,
             Amy and Maurer, Willi",
  journal = "Biom. J.",
  volume  =  48,
  number  =  4,
  pages   = "623--634",
  month   =  aug,
  year    =  2006
}

@ARTICLE{Koenig2008-jl,
  title   = "Adaptive Dunnett tests for treatment selection",
  author  = "Koenig, Franz and Brannath, Werner and Bretz, Frank and Posch,
             Martin",
  journal = "Stat. Med.",
  volume  =  27,
  number  =  10,
  pages   = "1612--1625",
  month   =  may,
  year    =  2008
}

@ARTICLE{Schmidli2006-ep,
  title   = "Confirmatory seamless phase {II/III} clinical trials with
             hypotheses selection at interim: applications and practical
             considerations",
  author  = "Schmidli, Heinz and Bretz, Frank and Racine, Amy and Maurer, Willi",
  journal = "Biom. J.",
  volume  =  48,
  number  =  4,
  pages   = "635--643",
  month   =  aug,
  year    =  2006
}

@ARTICLE{Shen2001-bf,
  title   = "An improved method of evaluating drug effect in a multiple dose
             clinical trial",
  author  = "Shen, L",
  journal = "Stat. Med.",
  volume  =  20,
  number  =  13,
  pages   = "1913--1929",
  month   =  jul,
  year    =  2001
}

@TECHREPORT{noauthor_2009-az,
  title       = "{Code of Federal Regulations -- Title 21 -- Food and Drugs}",
  institution = "U.S. Food and Drug Administration",
  month       =  apr,
  year        =  2009
}

@ARTICLE{De_Winter2008-bp,
  title   = "Population pharmacokinetics of mycophenolic acid : a comparison
             between enteric-coated mycophenolate sodium and mycophenolate
             mofetil in renal transplant recipients",
  author  = "de Winter, Brenda C M and van Gelder, Teun and Glander, Petra and
             Cattaneo, Dario and Tedesco-Silva, Helio and Neumann, Irmgard and
             Hilbrands, Luuk and van Hest, Reinier M and Pescovitz, Mark D and
             Budde, Klemens and Mathot, Ron A A",
  journal = "Clin. Pharmacokinet.",
  volume  =  47,
  number  =  12,
  pages   = "827--838",
  year    =  2008
}

@ARTICLE{Fine1999-as,
  title     = "A Proportional Hazards Model for the Subdistribution of a
               Competing Risk",
  author    = "Fine, Jason P and Gray, Robert J",
  journal   = "J. Am. Stat. Assoc.",
  publisher = "American Statistical Association",
  volume    =  94,
  number    =  446,
  pages     = "496--509",
  month     =  jun,
  year      =  1999,
  copyright = "Copyright \copyright{} 1999 American Statistical Association"
}

@ARTICLE{Starling2007-vj,
  title   = "Sustained benefits of the {{CorCap} Cardiac Support Device} on
             left ventricular remodeling: three year follow-up results from the
             {A}corn clinical trial",
  author  = "Starling, Randall C and Jessup, Mariell and Oh, Jae K and Sabbah,
             Hani N and Acker, Michael A and Mann, Douglas L and Kubo, Spencer
             H",
  journal = "Ann. Thorac. Surg.",
  volume  =  84,
  number  =  4,
  pages   = "1236--1242",
  month   =  oct,
  year    =  2007
}

@ARTICLE{Mann2004-dz,
  title   = "Rationale, design, and methods for a pivotal randomized clinical
             trial for the assessment of a cardiac support device in patients
             with {New Y}ork health association class {III-IV} heart failure",
  author  = "Mann, Douglas L and Acker, Michael A and Jessup, Mariell and
             Sabbah, Hani N and Starling, Randall C and Kubo, Spencer H and
             {Acorn Investigators and Study Coordinators}",
  journal = "J. Card. Fail.",
  volume  =  10,
  number  =  3,
  pages   = "185--192",
  month   =  jun,
  year    =  2004
}

@ARTICLE{Mann2007-ft,
  title   = "Clinical evaluation of the {{CorCap} Cardiac Support Device} in
             patients with dilated cardiomyopathy",
  author  = "Mann, Douglas L and Acker, Michael A and Jessup, Mariell and
             Sabbah, Hani N and Starling, Randall C and Kubo, Spencer H and
             {Acorn Trial Principal Investigators and Study Coordinators}",
  journal = "Ann. Thorac. Surg.",
  volume  =  84,
  number  =  4,
  pages   = "1226--1235",
  month   =  oct,
  year    =  2007
}

@ARTICLE{Erol-Yilmaz2005-gh,
  title   = "Cardiac resynchronization induces favorable neurohumoral changes",
  author  = "Erol-Yilmaz, Ayten and Verberne, Hein J and Schrama, Tim A and
             Hrudova, Jana and De Winter, Robbert J and Van Eck-Smit, Berthe L
             F and De Bruin, Rianne and Bax, Jeroen J and Schalij, Martin J and
             Wilde, Arthur A and Tukkie, Raymond",
  journal = "Pacing Clin. Electrophysiol.",
  volume  =  28,
  number  =  4,
  pages   = "304--310",
  month   =  apr,
  year    =  2005
}

@ARTICLE{Bolognese2002-hv,
  title   = "Left ventricular remodeling after primary coronary angioplasty:
             patterns of left ventricular dilation and long-term prognostic
             implications",
  author  = "Bolognese, Leonardo and Neskovic, Aleksandar N and Parodi, Guido
             and Cerisano, Giampaolo and Buonamici, Piergiovanni and Santoro,
             Giovanni M and Antoniucci, David",
  journal = "Circulation",
  volume  =  106,
  number  =  18,
  pages   = "2351--2357",
  month   =  oct,
  year    =  2002
}

@ARTICLE{Doughty2004-ky,
  title   = "Effects of carvedilol on left ventricular remodeling after acute
             myocardial infarction: the {{CAPRICORN} Echo Substudy}",
  author  = "Doughty, Robert N and Whalley, Gillian A and Walsh, Helen A and
             Gamble, Greg D and L{\'o}pez-Send{\'o}n, Jos{\'e} and Sharpe,
             Norman and {CAPRICORN Echo Substudy Investigators}",
  journal = "Circulation",
  volume  =  109,
  number  =  2,
  pages   = "201--206",
  month   =  jan,
  year    =  2004
}

@ARTICLE{Cleland2001-yo,
  title   = "The {CARE-HF} study ({{CArdiac} {REsynchronisation} in Heart
             Failure study}): rationale, design and end-points",
  author  = "Cleland, J G and Daubert, J C and Erdmann, E and Freemantle, N and
             Gras, D and Kappenberger, L and Klein, W and Tavazzi, L and
             {CARE-HF study Steering Committee and Investigators}",
  journal = "Eur. J. Heart Fail.",
  volume  =  3,
  number  =  4,
  pages   = "481--489",
  month   =  aug,
  year    =  2001
}

@ARTICLE{Cleland2005-db,
  title   = "The effect of cardiac resynchronization on morbidity and mortality
             in heart failure",
  author  = "Cleland, John G F and Daubert, Jean-Claude and Erdmann, Erland and
             Freemantle, Nick and Gras, Daniel and Kappenberger, Lukas and
             Tavazzi, Luigi and {Cardiac Resynchronization-Heart Failure
             (CARE-HF) Study Investigators}",
  journal = "N. Engl. J. Med.",
  volume  =  352,
  number  =  15,
  pages   = "1539--1549",
  month   =  apr,
  year    =  2005
}

@ARTICLE{Migrino1997-nw,
  title   = "End-systolic volume index at 90 to 180 minutes into reperfusion
             therapy for acute myocardial infarction is a strong predictor of
             early and late mortality. {The Global Utilization of Streptokinase
             and {t-PA} for Occluded Coronary Arteries ({GUSTO)-I} Angiographic
             Investigators}",
  author  = "Migrino, R Q and Young, J B and Ellis, S G and White, H D and
             Lundergan, C F and Miller, D P and Granger, C B and Ross, A M and
             Califf, R M and Topol, E J",
  journal = "Circulation",
  volume  =  96,
  number  =  1,
  pages   = "116--121",
  month   =  jul,
  year    =  1997
}

@ARTICLE{Bristow2004-kp,
  title   = "Cardiac-resynchronization therapy with or without an implantable
             defibrillator in advanced chronic heart failure",
  author  = "Bristow, Michael R and Saxon, Leslie A and Boehmer, John and
             Krueger, Steven and Kass, David A and De Marco, Teresa and Carson,
             Peter and DiCarlo, Lorenzo and DeMets, David and White, Bill G and
             DeVries, Dale W and Feldman, Arthur M and {Comparison of Medical
             Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION)
             Investigators}",
  journal = "N. Engl. J. Med.",
  volume  =  350,
  number  =  21,
  pages   = "2140--2150",
  month   =  may,
  year    =  2004
}

@ARTICLE{Dill2009-lo,
  title   = "Intracoronary administration of bone marrow-derived progenitor
             cells improves left ventricular function in patients at risk for
             adverse remodeling after acute {{ST}-segment} elevation myocardial
             infarction: results of the {Reinfusion of Enriched Progenitor
             cells And Infarct Remodeling in Acute Myocardial Infarction} study
             ({{REPAIR-AMI}}) cardiac magnetic resonance imaging substudy",
  author  = "Dill, Thorsten and Sch{\"a}chinger, Volker and Rolf, Andreas and
             M{\"o}llmann, Susanne and Thiele, Holger and Tillmanns, Harald and
             Assmus, Birgit and Dimmeler, Stefanie and Zeiher, Andreas M and
             Hamm, Christian",
  journal = "Am. Heart J.",
  volume  =  157,
  number  =  3,
  pages   = "541--547",
  month   =  mar,
  year    =  2009
}

@ARTICLE{Pitt2003-cx,
  title   = "Eplerenone, a selective aldosterone blocker, in patients with left
             ventricular dysfunction after myocardial infarction",
  author  = "Pitt, Bertram and Remme, Willem and Zannad, Faiez and Neaton,
             James and Martinez, Felipe and Roniker, Barbara and Bittman,
             Richard and Hurley, Steve and Kleiman, Jay and Gatlin, Marjorie
             and {Eplerenone Post-Acute Myocardial Infarction Heart Failure
             Efficacy and Survival Study Investigators}",
  journal = "N. Engl. J. Med.",
  volume  =  348,
  number  =  14,
  pages   = "1309--1321",
  month   =  apr,
  year    =  2003
}

@ARTICLE{Ganame2009-uy,
  title   = "Impact of myocardial haemorrhage on left ventricular function and
             remodelling in patients with reperfused acute myocardial
             infarction",
  author  = "Ganame, Javier and Messalli, Giancarlo and Dymarkowski, Steven and
             Rademakers, Frank E and Desmet, Walter and Van de Werf, Frans and
             Bogaert, Jan",
  journal = "Eur. Heart J.",
  volume  =  30,
  number  =  12,
  pages   = "1440--1449",
  month   =  jun,
  year    =  2009
}

@ARTICLE{Levy2006-tf,
  title   = "{The Seattle Heart Failure Model}: prediction of survival in heart
             failure",
  author  = "Levy, Wayne C and Mozaffarian, Dariush and Linker, David T and
             Sutradhar, Santosh C and Anker, Stefan D and Cropp, Anne B and
             Anand, Inder and Maggioni, Aldo and Burton, Paul and Sullivan,
             Mark D and Pitt, Bertram and Poole-Wilson, Philip A and Mann,
             Douglas L and Packer, Milton",
  journal = "Circulation",
  volume  =  113,
  number  =  11,
  pages   = "1424--1433",
  month   =  mar,
  year    =  2006
}

@ARTICLE{Steinbeck2009-zm,
  title   = "Defibrillator implantation early after myocardial infarction",
  author  = "Steinbeck, Gerhard and Andresen, Dietrich and Seidl, Karlheinz and
             Brachmann, Johannes and Hoffmann, Ellen and Wojciechowski, Dariusz
             and Kornacewicz-Jach, Zdzis{\l}awa and Sredniawa, Beata and
             Lupkovics, G{\'e}za and Hofg{\"a}rtner, Franz and Lubinski,
             Andrzej and Rosenqvist, M{\aa}rten and Habets, Alphonsus and
             Wegscheider, Karl and Senges, Jochen and {IRIS Investigators}",
  journal = "N. Engl. J. Med.",
  volume  =  361,
  number  =  15,
  pages   = "1427--1436",
  month   =  oct,
  year    =  2009
}

@ARTICLE{Quinones2000-np,
  title   = "Echocardiographic predictors of clinical outcome in patients with
             left ventricular dysfunction enrolled in the {SOLVD} registry and
             trials: significance of left ventricular hypertrophy. Studies of
             Left Ventricular Dysfunction",
  author  = "Qui{\~n}ones, M A and Greenberg, B H and Kopelen, H A and
             Koilpillai, C and Limacher, M C and Shindler, D M and Shelton, B J
             and Weiner, D H",
  journal = "J. Am. Coll. Cardiol.",
  volume  =  35,
  number  =  5,
  pages   = "1237--1244",
  month   =  apr,
  year    =  2000
}

@ARTICLE{Carrabba2009-ij,
  title   = "Comparison of effects of primary coronary angioplasty on left
             ventricular remodeling and heart failure in patients or =70 years
             with acute myocardial infarction",
  author  = "Carrabba, Nazario and Parodi, Guido and Valenti, Renato and
             Migliorini, Angela and Antoniucci, David",
  journal = "Am. J. Cardiol.",
  volume  =  104,
  number  =  7,
  pages   = "926--931",
  month   =  oct,
  year    =  2009
}

@ARTICLE{Moss2009-tw,
  title   = "Cardiac-resynchronization therapy for the prevention of
             heart-failure events",
  author  = "Moss, Arthur J and Hall, W Jackson and Cannom, David S and Klein,
             Helmut and Brown, Mary W and Daubert, James P and Estes, 3rd, N A
             Mark and Foster, Elyse and Greenberg, Henry and Higgins, Steven L
             and Pfeffer, Marc A and Solomon, Scott D and Wilber, David and
             Zareba, Wojciech and {MADIT-CRT Trial Investigators}",
  journal = "N. Engl. J. Med.",
  volume  =  361,
  number  =  14,
  pages   = "1329--1338",
  month   =  oct,
  year    =  2009
}

@ARTICLE{Young2003-vt,
  title   = "Combined cardiac resynchronization and implantable cardioversion
             defibrillation in advanced chronic heart failure: the {{MIRACLE}
             {ICD} Trial}",
  author  = "Young, James B and Abraham, William T and Smith, Andrew L and
             Leon, Angel R and Lieberman, Randy and Wilkoff, Bruce and Canby,
             Robert C and Schroeder, John S and Liem, L Bing and Hall, Shelley
             and Wheelan, Kevin and {Multicenter InSync ICD Randomized Clinical
             Evaluation (MIRACLE ICD) Trial Investigators}",
  journal = "JAMA",
  volume  =  289,
  number  =  20,
  pages   = "2685--2694",
  month   =  may,
  year    =  2003
}

@ARTICLE{Abraham2002-nq,
  title   = "Cardiac resynchronization in chronic heart failure",
  author  = "Abraham, William T and Fisher, Westby G and Smith, Andrew L and
             Delurgio, David B and Leon, Angel R and Loh, Evan and Kocovic,
             Dusan Z and Packer, Milton and Clavell, Alfredo L and Hayes, David
             L and Ellestad, Myrvin and Trupp, Robin J and Underwood, Jackie
             and Pickering, Faith and Truex, Cindy and McAtee, Peggy and
             Messenger, John and {MIRACLE Study Group. Multicenter InSync
             Randomized Clinical Evaluation}",
  journal = "N. Engl. J. Med.",
  volume  =  346,
  number  =  24,
  pages   = "1845--1853",
  month   =  jun,
  year    =  2002
}

@ARTICLE{Nicolosi1996-tq,
  title   = "The prognostic value of predischarge quantitative two-dimensional
             echocardiographic measurements and the effects of early lisinopril
             treatment on left ventricular structure and function after acute
             myocardial infarction in the {{GISSI}-3} Trial. {Gruppo Italiano
             per lo Studio della Sopravvivenza nell'Infarto Miocardico}",
  author  = "Nicolosi, G L and Latini, R and Marino, P and Maggioni, A P and
             Barlera, S and Franzosi, M G and Geraci, E and Santoro, L and
             Tavazzi, L and Tognoni, G and Vecchio, C and Volpi, A",
  journal = "Eur. Heart J.",
  volume  =  17,
  number  =  11,
  pages   = "1646--1656",
  month   =  nov,
  year    =  1996
}

@ARTICLE{Fruhwald2007-na,
  title   = "Early and sustained effects of cardiac resynchronization therapy
             on {N}-terminal pro-{B}-type natriuretic peptide in patients with
             moderate to severe heart failure and cardiac dyssynchrony",
  author  = "Fruhwald, Friedrich M and Fahrleitner-Pammer, Astrid and Berger,
             Rudolf and Leyva, Francisco and Freemantle, Nick and Erdmann,
             Erland and Gras, Daniel and Kappenberger, Lukas and Tavazzi, Luigi
             and Daubert, Jean-Claude and Cleland, John G F",
  journal = "Eur. Heart J.",
  volume  =  28,
  number  =  13,
  pages   = "1592--1597",
  month   =  jul,
  year    =  2007
}

@ARTICLE{Linde2008-va,
  title   = "Randomized trial of cardiac resynchronization in mildly
             symptomatic heart failure patients and in asymptomatic patients
             with left ventricular dysfunction and previous heart failure
             symptoms",
  author  = "Linde, Cecilia and Abraham, William T and Gold, Michael R and St
             John Sutton, Martin and Ghio, Stefano and Daubert, Claude and
             {REVERSE (REsynchronization reVErses Remodeling in Systolic left
             vEntricular dysfunction) Study Group}",
  journal = "J. Am. Coll. Cardiol.",
  volume  =  52,
  number  =  23,
  pages   = "1834--1843",
  month   =  dec,
  year    =  2008
}

@ARTICLE{Moye1991-fk,
  title   = "Rationale, design and baseline characteristics of the survival and
             ventricular enlargement trial. {SAVE} Investigators",
  author  = "Moy{\'e}, L A and Pfeffer, M A and Braunwald, E",
  journal = "Am. J. Cardiol.",
  volume  =  68,
  number  =  14,
  pages   = "70D--79D",
  month   =  nov,
  year    =  1991
}

@ARTICLE{St_John_Sutton1994-dm,
  title   = "Quantitative two-dimensional echocardiographic measurements are
             major predictors of adverse cardiovascular events after acute
             myocardial infarction. The protective effects of captopril",
  author  = "St John Sutton, M and Pfeffer, M A and Plappert, T and Rouleau, J
             L and Moy{\'e}, L A and Dagenais, G R and Lamas, G A and Klein, M
             and Sussex, B and Goldman, S",
  journal = "Circulation",
  volume  =  89,
  number  =  1,
  pages   = "68--75",
  month   =  jan,
  year    =  1994
}

@ARTICLE{Pfeffer1992-nt,
  title   = "Effect of captopril on mortality and morbidity in patients with
             left ventricular dysfunction after myocardial infarction. Results
             of the survival and ventricular enlargement trial. The {SAVE}
             Investigators",
  author  = "Pfeffer, M A and Braunwald, E and Moy{\'e}, L A and Basta, L and
             Brown, Jr, E J and Cuddy, T E and Davis, B R and Geltman, E M and
             Goldman, S and Flaker, G C",
  journal = "N. Engl. J. Med.",
  volume  =  327,
  number  =  10,
  pages   = "669--677",
  month   =  sep,
  year    =  1992
}

@ARTICLE{Moses2003-fu,
  title   = "Sirolimus-eluting stents versus standard stents in patients with
             stenosis in a native coronary artery",
  author  = "Moses, Jeffrey W and Leon, Martin B and Popma, Jeffrey J and
             Fitzgerald, Peter J and Holmes, David R and O'Shaughnessy, Charles
             and Caputo, Ronald P and Kereiakes, Dean J and Williams, David O
             and Teirstein, Paul S and Jaeger, Judith L and Kuntz, Richard E
             and {SIRIUS Investigators}",
  journal = "N. Engl. J. Med.",
  volume  =  349,
  number  =  14,
  pages   = "1315--1323",
  month   =  oct,
  year    =  2003
}

@ARTICLE{Udelson2002-pk,
  title   = "Relation between left ventricular remodeling and clinical outcomes
             in heart failure patients with left ventricular systolic
             dysfunction",
  author  = "Udelson, James E and Konstam, Marvin A",
  journal = "J. Card. Fail.",
  volume  =  8,
  number  = "6 Suppl",
  pages   = "S465--71",
  month   =  dec,
  year    =  2002
}

@ARTICLE{Udelson2003-nr,
  title   = "New concepts in post-infarction ventricular remodeling",
  author  = "Udelson, James E and Patten, Richard D and Konstam, Marvin A",
  journal = "Rev. Cardiovasc. Med.",
  volume  = "4 Suppl 3",
  pages   = "S3--12",
  year    =  2003
}

@ARTICLE{Solomon2005-fa,
  title   = "Changes in ventricular size and function in patients treated with
             valsartan, captopril, or both after myocardial infarction",
  author  = "Solomon, Scott D and Skali, Hicham and Anavekar, Nagesh S and
             Bourgoun, Mikhail and Barvik, Stale and Ghali, Jalal K and
             Warnica, J Wayne and Khrakovskaya, Margarita and Arnold, J Malcolm
             O and Schwartz, Yuri and Velazquez, Eric J and Califf, Robert M
             and McMurray, John V and Pfeffer, Marc A",
  journal = "Circulation",
  volume  =  111,
  number  =  25,
  pages   = "3411--3419",
  month   =  jun,
  year    =  2005
}

@ARTICLE{Zanolla1999-jd,
  title   = "The extent of regional wall motion abnormalities identifies
             patients at risk of extensive left ventricular remodeling:
             implications for the design of post myocardial infarction trials",
  author  = "Zanolla, L and Marino, P and Golia, G and Anselmi, M and Zardini,
             P and Borghi, C and Ambrosioni, E",
  journal = "G. Ital. Cardiol.",
  volume  =  29,
  number  =  1,
  pages   = "20--26",
  month   =  jan,
  year    =  1999
}

@ARTICLE{Carroll2003-mm,
  title   = "On the use and utility of the {W}eibull model in the analysis of
             survival data",
  author  = "Carroll, Kevin J",
  journal = "Control. Clin. Trials",
  volume  =  24,
  number  =  6,
  pages   = "682--701",
  month   =  dec,
  year    =  2003
}

@ARTICLE{Kannel1999-pt,
  title   = "Profile for estimating risk of heart failure",
  author  = "Kannel, W B and D'Agostino, R B and Silbershatz, H and Belanger, A
             J and Wilson, P W and Levy, D",
  journal = "Arch. Intern. Med.",
  volume  =  159,
  number  =  11,
  pages   = "1197--1204",
  month   =  jun,
  year    =  1999
}

@ARTICLE{Eikenberry2009-ww,
  title   = "The dynamics of a delay model of hepatitis {B} virus infection
             with logistic hepatocyte growth",
  author  = "Eikenberry, Steffen and Hews, Sarah and Nagy, John D and Kuang,
             Yang",
  journal = "Math. Biosci. Eng.",
  volume  =  6,
  number  =  2,
  pages   = "283--299",
  month   =  apr,
  year    =  2009
}

@ARTICLE{Abduljalil2009-qy,
  title   = "Modeling the autoinhibition of clarithromycin metabolism during
             repeated oral administration",
  author  = "Abduljalil, Khaled and Kinzig, Martina and Bulitta, J{\"u}rgen and
             Horkovics-Kovats, Stefan and S{\"o}rgel, Fritz and Rodamer,
             Michael and Fuhr, Uwe",
  journal = "Antimicrob. Agents Chemother.",
  volume  =  53,
  number  =  7,
  pages   = "2892--2901",
  month   =  jul,
  year    =  2009
}

@TECHREPORT{Mondick2008-nf,
  title       = "Population {Pharmacokinetic-Pharmacodynamic} Modeling of
                 {AKR-501} in Healthy Volunteers",
  author      = "Mondick, J T",
  institution = "Eisai Inc",
  month       =  oct,
  year        =  2008
}

@ARTICLE{Chiu2007-bq,
  title     = "An Approximate Method for Population Toxicokinetic Analysis With
               Aggregated Data",
  author    = "Chiu, Weihsueh A and Bois, Frederic Y",
  journal   = "J. Agric. Biol. Environ. Stat.",
  publisher = "American Statistical Association",
  volume    =  12,
  number    =  3,
  pages     = "346--363",
  month     =  sep,
  year      =  2007
}

@ARTICLE{Pery2009-vw,
  title   = "Stochasticity in physiologically based kinetics models:
             implications for cancer risk assessment",
  author  = "P{\'e}ry, Alexandre Roger Raymond and Bois, Frederic Yves",
  journal = "Risk Anal.",
  volume  =  29,
  number  =  8,
  pages   = "1182--1191",
  month   =  aug,
  year    =  2009
}

@ARTICLE{Pery2009-xw,
  title   = "Development of a physiologically based kinetic model for
             99m-{T}echnetium-labelled carbon nanoparticles inhaled by humans",
  author  = "P{\'e}ry, Alexandre R R and Brochot, C{\'e}line and Hoet, Peter H
             M and Nemmar, Abderrahim and Bois, Fr{\'e}d{\'e}ric Y",
  journal = "Inhal. Toxicol.",
  volume  =  21,
  number  =  13,
  pages   = "1099--1107",
  month   =  nov,
  year    =  2009
}

@ARTICLE{Brochot2005-uh,
  title   = "Lumping in pharmacokinetics",
  author  = "Brochot, C{\'e}line and T{\'o}th, J{\'a}nos and Bois,
             Fr{\'e}d{\'e}ric Y",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  32,
  number  = "5-6",
  pages   = "719--736",
  month   =  dec,
  year    =  2005
}

@ARTICLE{Brochot2005-se,
  title   = "Use of a chemical probe to increase safety for human volunteers in
             toxicokinetic studies",
  author  = "Brochot, C{\'e}line and Bois, Fr{\'e}d{\'e}ric Y",
  journal = "Risk Anal.",
  volume  =  25,
  number  =  6,
  pages   = "1559--1571",
  month   =  dec,
  year    =  2005
}

@ARTICLE{Chiu2006-tw,
  title   = "Revisiting the population toxicokinetics of tetrachloroethylene",
  author  = "Chiu, Weihsueh A and Bois, Fr{\'e}d{\'e}ric Y",
  journal = "Arch. Toxicol.",
  volume  =  80,
  number  =  6,
  pages   = "382--385",
  month   =  jun,
  year    =  2006
}

@ARTICLE{Diack2005-oo,
  title   = "Pharmacokinetic-pharmacodynamic models for categorical toxicity
             data",
  author  = "Diack, Cheikh and Bois, Fr{\'e}d{\'e}ric Y",
  journal = "Regul. Toxicol. Pharmacol.",
  volume  =  41,
  number  =  1,
  pages   = "55--65",
  month   =  feb,
  year    =  2005
}

@ARTICLE{Brochot2004-fd,
  title   = "Extension of the isobolographic approach to interactions studies
             between more than two drugs: illustration with the convulsant
             interaction between pefloxacin, norfloxacin, and theophylline in
             rats",
  author  = "Brochot, C{\'e}line and Marchand, Sandrine and Couet, William and
             Gelman, Andrew and Bois, Fr{\'e}d{\'e}ric Y",
  journal = "J. Pharm. Sci.",
  volume  =  93,
  number  =  3,
  pages   = "553--562",
  month   =  mar,
  year    =  2004
}

@ARTICLE{Chiu2007-as,
  title   = "Toxicokinetics of inhaled trichloroethylene and
             tetrachloroethylene in humans at 1 ppm: empirical results and
             comparisons with previous studies",
  author  = "Chiu, Weihsueh A and Micallef, Sandrine and Monster, Aart C and
             Bois, Fr{\'e}d{\'e}ric Y",
  journal = "Toxicol. Sci.",
  volume  =  95,
  number  =  1,
  pages   = "23--36",
  month   =  jan,
  year    =  2007
}

@ARTICLE{Schmidt2009-eh,
  title   = "Distilling free-form natural laws from experimental data",
  author  = "Schmidt, Michael and Lipson, Hod",
  journal = "Science",
  volume  =  324,
  number  =  5923,
  pages   = "81--85",
  month   =  apr,
  year    =  2009
}

@ARTICLE{Zhou2009-rm,
  title   = "Differential pharmacodynamic effects of paclitaxel formulations in
             an intracranial rat brain tumor model",
  author  = "Zhou, Rong and Mazurchuk, Richard V and Tamburlin, Judith H and
             Harrold, John M and Mager, Donald E and Straubinger, Robert M",
  journal = "J. Pharmacol. Exp. Ther.",
  month   =  oct,
  year    =  2009
}

@ARTICLE{Toni2009-zz,
  title   = "Approximate Bayesian computation scheme for parameter inference
             and model selection in dynamical systems",
  author  = "Toni, Tina and Welch, David and Strelkowa, Natalja and Ipsen,
             Andreas and Stumpf, Michael P H",
  journal = "J. R. Soc. Interface",
  volume  =  6,
  number  =  31,
  pages   = "187--202",
  month   =  feb,
  year    =  2009
}

@ARTICLE{Wade2009-jq,
  title   = "Fluconazole dosing for the prevention or treatment of invasive
             candidiasis in young infants",
  author  = "Wade, Kelly C and Benjamin, Jr, Daniel K and Kaufman, David A and
             Ward, Robert M and Smith, Phillip B and Jayaraman, Bhuvana and
             Adamson, Peter C and Gastonguay, Marc R and Barrett, Jeffrey S",
  journal = "Pediatr. Infect. Dis. J.",
  volume  =  28,
  number  =  8,
  pages   = "717--723",
  month   =  aug,
  year    =  2009
}

@ARTICLE{Jennison2003-dg,
  title   = "Mid-course sample size modification in clinical trials based on
             the observed treatment effect",
  author  = "Jennison, Christopher and Turnbull, Bruce W",
  journal = "Stat. Med.",
  volume  =  22,
  number  =  6,
  pages   = "971--993",
  month   =  mar,
  year    =  2003
}

@ARTICLE{Tsiatis2003-ym,
  title     = "On the Inefficiency of the Adaptive Design for Monitoring
               Clinical Trials",
  author    = "Tsiatis, Anastasios A and Mehta, Cyrus",
  journal   = "Biometrika",
  publisher = "Biometrika Trust",
  volume    =  90,
  number    =  2,
  pages     = "367--378",
  month     =  jun,
  year      =  2003,
  copyright = "Copyright \copyright{} 2003 Biometrika Trust"
}

@ARTICLE{Petersson2009-kb,
  title   = "Semiparametric distributions with estimated shape parameters",
  author  = "Petersson, Klas J F and Hanze, Eva and Savic, Radojka M and
             Karlsson, Mats O",
  journal = "Pharm. Res.",
  volume  =  26,
  number  =  9,
  pages   = "2174--2185",
  month   =  sep,
  year    =  2009
}

@ARTICLE{Bazzoli2009-ip,
  title   = "Design evaluation and optimisation in multiple response nonlinear
             mixed effect models: {PFIM} 3.0",
  author  = "Bazzoli, Caroline and Retout, Sylvie and Mentr{\'e}, France",
  journal = "Comput. Methods Programs Biomed.",
  month   =  nov,
  year    =  2009
}

@ARTICLE{Wawra2007-kx,
  title   = "Extended analyses of the {W}nt/beta-catenin pathway: robustness
             and oscillatory behaviour",
  author  = "Wawra, Christian and K{\"u}hl, Michael and Kestler, Hans A",
  journal = "FEBS Lett.",
  volume  =  581,
  number  =  21,
  pages   = "4043--4048",
  month   =  aug,
  year    =  2007
}

@ARTICLE{Lee2003-as,
  title   = "The roles of {{APC} and A}xin derived from experimental and
             theoretical analysis of the {W}nt pathway",
  author  = "Lee, Ethan and Salic, Adrian and Kr{\"u}ger, Roland and Heinrich,
             Reinhart and Kirschner, Marc W",
  journal = "PLoS Biol.",
  volume  =  1,
  number  =  1,
  pages   = "E10",
  month   =  oct,
  year    =  2003
}

@ARTICLE{Mirams2010-nv,
  title   = "A multiple timescale analysis of a mathematical model of the
             {W}nt/beta-catenin signalling pathway",
  author  = "Mirams, Gary R and Byrne, Helen M and King, John R",
  journal = "J. Math. Biol.",
  volume  =  60,
  number  =  1,
  pages   = "131--160",
  month   =  jan,
  year    =  2010
}

@ARTICLE{Yang2009-gr,
  title   = "Comparison of Two Pharmacodynamic Transduction Models for the
             Analysis of Tumor Therapeutic Responses in Model Systems",
  author  = "Yang, Jun and Mager, Donald E and Straubinger, Robert M",
  journal = "AAPS J.",
  month   =  nov,
  year    =  2009
}

@ARTICLE{Bulitta2009-ns,
  title   = "Multiple-pool cell lifespan models for neutropenia to assess the
             population pharmacodynamics of unbound paclitaxel from two
             formulations in cancer patients",
  author  = "Bulitta, J{\"u}rgen B and Zhao, Ping and Arnold, Robert D and
             Kessler, Dean R and Daifuku, Richard and Pratt, James and Luciano,
             Gabriel and Hanauske, Axel-R and Gelderblom, Hans and Awada, Ahmad
             and Jusko, William J",
  journal = "Cancer Chemother. Pharmacol.",
  volume  =  63,
  number  =  6,
  pages   = "1035--1048",
  month   =  may,
  year    =  2009
}

@ARTICLE{Bulitta2009-yb,
  title   = "Mechanistic population pharmacokinetics of total and unbound
             paclitaxel for a new nanodroplet formulation versus {T}axol in
             cancer patients",
  author  = "Bulitta, J{\"u}rgen B and Zhao, Ping and Arnold, Robert D and
             Kessler, Dean R and Daifuku, Richard and Pratt, James and Luciano,
             Gabriel and Hanauske, Axel-R and Gelderblom, Hans and Awada, Ahmad
             and Jusko, William J",
  journal = "Cancer Chemother. Pharmacol.",
  volume  =  63,
  number  =  6,
  pages   = "1049--1063",
  month   =  may,
  year    =  2009
}

@ARTICLE{Klingenberg2009-vw,
  title   = "Proof of concept and dose estimation with binary responses under
             model uncertainty",
  author  = "Klingenberg, B",
  journal = "Stat. Med.",
  volume  =  28,
  number  =  2,
  pages   = "274--292",
  month   =  jan,
  year    =  2009
}

@ARTICLE{Smith2009-fi,
  title   = "A Look at the {Low-Carbohydrate} {DIet}",
  author  = "Smith, Steven R",
  journal = "N. Engl. J. Med.",
  volume  =  361,
  number  =  23,
  pages   = "2286--2282",
  year    =  2009
}

@ARTICLE{Liang1998-ng,
  title   = "Pitfalls in pharmacokinetic multicompartment analysis",
  author  = "Liang, E and Derendorf, H",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  26,
  number  =  2,
  pages   = "247--260",
  month   =  apr,
  year    =  1998
}

@ARTICLE{Pfeffer2003-gr,
  title   = "Valsartan, captopril, or both in myocardial infarction complicated
             by heart failure, left ventricular dysfunction, or both",
  author  = "Pfeffer, Marc A and McMurray, John J V and Velazquez, Eric J and
             Rouleau, Jean-Lucien and K{\o}ber, Lars and Maggioni, Aldo P and
             Solomon, Scott D and Swedberg, Karl and Van de Werf, Frans and
             White, Harvey and Leimberger, Jeffrey D and Henis, Marc and
             Edwards, Susan and Zelenkofske, Steven and Sellers, Mary Ann and
             Califf, Robert M and {Valsartan in Acute Myocardial Infarction
             Trial Investigators}",
  journal = "N. Engl. J. Med.",
  volume  =  349,
  number  =  20,
  pages   = "1893--1906",
  month   =  nov,
  year    =  2003
}

@ARTICLE{Bland2004-bc,
  title   = "The logrank test",
  author  = "Bland, J Martin and Altman, Douglas G",
  journal = "BMJ",
  volume  =  328,
  number  =  7447,
  pages   = "1073",
  month   =  may,
  year    =  2004
}

@ARTICLE{Langdon2007-ke,
  title   = "Linking preclinical and clinical whole-body physiologically based
             pharmacokinetic models with prior distributions in {NONMEM}",
  author  = "Langdon, Grant and Gueorguieva, Ivelina and Aarons, Leon and
             Karlsson, Mats",
  journal = "Eur. J. Clin. Pharmacol.",
  volume  =  63,
  number  =  5,
  pages   = "485--498",
  month   =  may,
  year    =  2007
}

@ARTICLE{Rhodin2009-lm,
  title   = "Human renal function maturation: a quantitative description using
             weight and postmenstrual age",
  author  = "Rhodin, Malin M and Anderson, Brian J and Peters, A Michael and
             Coulthard, Malcolm G and Wilkins, Barry and Cole, Michael and
             Chatelut, Etienne and Grubb, Anders and Veal, Gareth J and Keir,
             Michael J and Holford, Nick H G",
  journal = "Pediatr. Nephrol.",
  volume  =  24,
  number  =  1,
  pages   = "67--76",
  month   =  jan,
  year    =  2009
}

@ARTICLE{Ariens1964-gc,
  title    = "A molecular basis for drug action. The interaction of one or more
              drugs with different receptors",
  author   = "Ariens, E J and Simonis, A M",
  journal  = "J. Pharm. Pharmacol.",
  volume   =  16,
  pages    = "289--312",
  month    =  may,
  year     =  1964,
  keywords = "AMINOBENZOIC ACID; ANTIHISTAMINICS; ATROPINE; CARBACHOL;
              CHEMISTRY, PHARMACEUTICAL; DIBENAMINE; EXPERIMENTAL LAB STUDY;
              HISTAMINE; ISOPROTERENOL; NOREPINEPHRINE; PAPAVERINE;
              PARASYMPATHOMIMETICS; PHARMACOLOGY; REVIEW"
}

@TECHREPORT{noauthor_2009-az,
  title       = "Guideline on the clinical development of medicinal projects
                 for the treatment of cystic fibrosis",
  institution = "European Medicines Agency (EMEA)",
  year        =  2009
}

@ARTICLE{Shih2006-dr,
  title   = "Group sequential, sample size re-estimation and two-stage adaptive
             designs in clinical trials: a comparison",
  author  = "Shih, Weichung Joe",
  journal = "Stat. Med.",
  volume  =  25,
  number  =  6,
  pages   = "933--941",
  month   =  mar,
  year    =  2006
}

@ARTICLE{Brannath2009-qy,
  title   = "Confirmatory adaptive designs with Bayesian decision tools for a
             targeted therapy in oncology",
  author  = "Brannath, Werner and Zuber, Emmanuel and Branson, Michael and
             Bretz, Frank and Gallo, Paul and Posch, Martin and Racine-Poon,
             Amy",
  journal = "Stat. Med.",
  volume  =  28,
  number  =  10,
  pages   = "1445--1463",
  month   =  may,
  year    =  2009
}

@ARTICLE{Schafer2001-da,
  title   = "Modification of the sample size and the schedule of interim
             analyses in survival trials based on data inspections",
  author  = "Sch{\"a}fer, H and M{\"u}ller, H H",
  journal = "Stat. Med.",
  volume  =  20,
  number  =  24,
  pages   = "3741--3751",
  month   =  dec,
  year    =  2001
}

@ARTICLE{Johansen1984-lo,
  title   = "Variations in renal threshold for glucose in Type 1
             (insulin-dependent) diabetes mellitus",
  author  = "Johansen, K and Svendsen, P A and L{\o}rup, B",
  journal = "Diabetologia",
  volume  =  26,
  number  =  3,
  pages   = "180--182",
  month   =  mar,
  year    =  1984
}

@ARTICLE{Spiegelhalter2003-bp,
  title   = "Bayesian approaches to multiple sources of evidence and
             uncertainty in complex cost-effectiveness modelling",
  author  = "Spiegelhalter, David J and Best, Nicola G",
  journal = "Stat. Med.",
  volume  =  22,
  number  =  23,
  pages   = "3687--3709",
  month   =  dec,
  year    =  2003
}

@ARTICLE{Yang2009-fl,
  title   = "Evaluations of {B}ayesian and maximum likelihood methods in {PK}
             models with below-quantification-limit data",
  author  = "Yang, Shuying and Roger, James",
  journal = "Pharm. Stat.",
  month   =  dec,
  year    =  2009
}

@ARTICLE{Savic2009-bx,
  title   = "Evaluation of an extended grid method for estimation using
             nonparametric distributions",
  author  = "Savic, Radojka M and Karlsson, Mats O",
  journal = "AAPS J.",
  volume  =  11,
  number  =  3,
  pages   = "615--627",
  month   =  sep,
  year    =  2009
}

@ARTICLE{Hu2009-fl,
  title   = "Confirmatory analysis for phase {III} population pharmacokinetics",
  author  = "Hu, Chuanpu and Zhang, Ji and Zhou, Honghui",
  journal = "Pharm. Stat.",
  month   =  dec,
  year    =  2009
}

@ARTICLE{Ebeling1996-gb,
  title   = "Bone turnover markers and bone density across the menopausal
             transition",
  author  = "Ebeling, P R and Atley, L M and Guthrie, J R and Burger, H G and
             Dennerstein, L and Hopper, J L and Wark, J D",
  journal = "J. Clin. Endocrinol. Metab.",
  volume  =  81,
  number  =  9,
  pages   = "3366--3371",
  month   =  sep,
  year    =  1996
}

@ARTICLE{Iki2006-je,
  title   = "Biochemical markers of bone turnover predict bone loss in
             perimenopausal women but not in postmenopausal women-the Japanese
             Population-based Osteoporosis ({JPOS}) Cohort Study",
  author  = "Iki, M and Morita, A and Ikeda, Y and Sato, Y and Akiba, T and
             Matsumoto, T and Nishino, H and Kagamimori, S and Kagawa, Y and
             Yoneshima, H and {JPOS Study Group}",
  journal = "Osteoporos. Int.",
  volume  =  17,
  number  =  7,
  pages   = "1086--1095",
  year    =  2006
}

@ARTICLE{Garnero1996-qy,
  title   = "Increased bone turnover in late postmenopausal women is a major
             determinant of osteoporosis",
  author  = "Garnero, P and Sornay-Rendu, E and Chapuy, M C and Delmas, P D",
  journal = "J. Bone Miner. Res.",
  volume  =  11,
  number  =  3,
  pages   = "337--349",
  month   =  mar,
  year    =  1996
}

@ARTICLE{Gorai1997-zt,
  title   = "Specific changes of urinary excretion of cross-linked
             N-telopeptides of type {I} collagen in pre- and postmenopausal
             women: correlation with other markers of bone turnover",
  author  = "Gorai, I and Taguchi, Y and Chaki, O and Nakayama, M and
             Minaguchi, H",
  journal = "Calcif. Tissue Int.",
  volume  =  60,
  number  =  4,
  pages   = "317--322",
  month   =  apr,
  year    =  1997
}

@ARTICLE{Marcus1999-tu,
  title   = "The relationship of biochemical markers of bone turnover to bone
             density changes in postmenopausal women: results from the
             Postmenopausal {Estrogen/Progestin} Interventions ({PEPI}) trial",
  author  = "Marcus, R and Holloway, L and Wells, B and Greendale, G and James,
             M K and Wasilauskas, C and Kelaghan, J",
  journal = "J. Bone Miner. Res.",
  volume  =  14,
  number  =  9,
  pages   = "1583--1595",
  month   =  sep,
  year    =  1999
}

@ARTICLE{Southern2008-ua,
  title   = "Multi-scale computational modelling in biology and physiology",
  author  = "Southern, James and Pitt-Francis, Joe and Whiteley, Jonathan and
             Stokeley, Daniel and Kobashi, Hiromichi and Nobes, Ross and
             Kadooka, Yoshimasa and Gavaghan, David",
  journal = "Prog. Biophys. Mol. Biol.",
  volume  =  96,
  number  = "1-3",
  pages   = "60--89",
  year    =  2008
}

@ARTICLE{Millar2009-wh,
  title   = "Comparison of hierarchical Bayesian models for overdispersed count
             data using {DIC} and Bayes' factors",
  author  = "Millar, Russell B",
  journal = "Biometrics",
  volume  =  65,
  number  =  3,
  pages   = "962--969",
  month   =  sep,
  year    =  2009
}

@ARTICLE{Ravva2009-ak,
  title   = "Population pharmacokinetic analysis of varenicline in adult
             smokers",
  author  = "Ravva, Patanjali and Gastonguay, Marc R and Tensfeldt, Thomas G
             and Faessel, H{\'e}l{\`e}ne M",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  68,
  number  =  5,
  pages   = "669--681",
  month   =  nov,
  year    =  2009
}

@ARTICLE{Barras2009-xf,
  title   = "Modelling the occurrence and severity of enoxaparin-induced
             bleeding and bruising events",
  author  = "Barras, Michael A and Duffull, Stephen B and Atherton, John J and
             Green, Bruce",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  68,
  number  =  5,
  pages   = "700--711",
  month   =  nov,
  year    =  2009
}

@ARTICLE{Dargie2001-le,
  title   = "Effect of carvedilol on outcome after myocardial infarction in
             patients with left-ventricular dysfunction: the {CAPRICORN}
             randomised trial",
  author  = "Dargie, H J",
  journal = "Lancet",
  volume  =  357,
  number  =  9266,
  pages   = "1385--1390",
  month   =  may,
  year    =  2001
}

@ARTICLE{Kanai1994-mx,
  title   = "The human kidney low affinity Na+/glucose cotransporter {SGLT2}.
             Delineation of the major renal reabsorptive mechanism for
             D-glucose",
  author  = "Kanai, Y and Lee, W S and You, G and Brown, D and Hediger, M A",
  journal = "J. Clin. Invest.",
  volume  =  93,
  number  =  1,
  pages   = "397--404",
  month   =  jan,
  year    =  1994
}

@ARTICLE{Brooks2008-dj,
  title   = "Positron emission tomography analysis of [{11C]KW-6002} binding to
             human and rat adenosine {A2A} receptors in the brain",
  author  = "Brooks, D J and Doder, M and Osman, S and Luthra, S K and Hirani,
             E and Hume, S and Kase, H and Kilborn, J and Martindill, S and
             Mori, A",
  journal = "Synapse",
  volume  =  62,
  number  =  9,
  pages   = "671--681",
  month   =  sep,
  year    =  2008
}

@ARTICLE{Gupta2009-zi,
  title   = "A {Semi-Mechanistic} Model of {CP-690,550-Induced} Reduction in
             Neutrophil Counts in Patients With Rheumatoid Arthritis",
  author  = "Gupta, Pankaj and Friberg, Lena E and Karlsson, Mats O and
             Krishnaswami, Sriram and French, Jonathan",
  journal = "J. Clin. Pharmacol.",
  month   =  oct,
  year    =  2009
}

@ARTICLE{Bauer2004-uh,
  title   = "Modification of the sample size and the schedule of interim
             analyses in survival trials based on data inspections, by H.
             Sch{\"a}fer and {H.-H}. M{\"u}ller, Statistics in Medicine 2001;
             20: 3741-3751",
  author  = "Bauer, P and Posch, M",
  journal = "Stat. Med.",
  volume  =  23,
  number  =  8,
  pages   = "1333--4; author reply 1334--5",
  month   =  apr,
  year    =  2004
}

@ARTICLE{Matschinsky2009-en,
  title   = "Assessing the potential of glucokinase activators in diabetes
             therapy",
  author  = "Matschinsky, Franz M",
  journal = "Nat. Rev. Drug Discov.",
  volume  =  8,
  number  =  5,
  pages   = "399--416",
  month   =  may,
  year    =  2009
}

@ARTICLE{Gueguen2000-qn,
  title   = "The bioavailability of dietary calcium",
  author  = "Gu{\'e}guen, L and Pointillart, A",
  journal = "J. Am. Coll. Nutr.",
  volume  =  19,
  number  = "2 Suppl",
  pages   = "119S--136S",
  month   =  apr,
  year    =  2000
}

@ARTICLE{Reid1993-fu,
  title   = "Effect of calcium supplementation on bone loss in postmenopausal
             women",
  author  = "Reid, I R and Ames, R W and Evans, M C and Gamble, G D and Sharpe,
             S J",
  journal = "N. Engl. J. Med.",
  volume  =  328,
  number  =  7,
  pages   = "460--464",
  month   =  feb,
  year    =  1993
}

@ARTICLE{Khosla1998-uc,
  title   = "Relationship of serum sex steroid levels and bone turnover markers
             with bone mineral density in men and women: a key role for
             bioavailable estrogen",
  author  = "Khosla, S and Melton, 3rd, L J and Atkinson, E J and O'Fallon, W M
             and Klee, G G and Riggs, B L",
  journal = "J. Clin. Endocrinol. Metab.",
  volume  =  83,
  number  =  7,
  pages   = "2266--2274",
  month   =  jul,
  year    =  1998
}

@ARTICLE{Riggs1998-fg,
  title   = "A unitary model for involutional osteoporosis: estrogen deficiency
             causes both type {I} and type {II} osteoporosis in postmenopausal
             women and contributes to bone loss in aging men",
  author  = "Riggs, B L and Khosla, S and Melton, 3rd, L J",
  journal = "J. Bone Miner. Res.",
  volume  =  13,
  number  =  5,
  pages   = "763--773",
  month   =  may,
  year    =  1998
}

@ARTICLE{Civitelli1988-wf,
  title   = "Effects of one-year treatment with estrogens on bone mass,
             intestinal calcium absorption, and 25-hydroxyvitamin {D-1}
             alpha-hydroxylase reserve in postmenopausal osteoporosis",
  author  = "Civitelli, R and Agnusdei, D and Nardi, P and Zacchei, F and
             Avioli, L V and Gennari, C",
  journal = "Calcif. Tissue Int.",
  volume  =  42,
  number  =  2,
  pages   = "77--86",
  month   =  feb,
  year    =  1988
}

@ARTICLE{Bies2006-wc,
  title   = "A genetic algorithm-based, hybrid machine learning approach to
             model selection",
  author  = "Bies, Robert R and Muldoon, Matthew F and Pollock, Bruce G and
             Manuck, Steven and Smith, Gwenn and Sale, Mark E",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  33,
  number  =  2,
  pages   = "195--221",
  month   =  apr,
  year    =  2006
}

@ARTICLE{Sowers2006-zl,
  title   = "Hormone predictors of bone mineral density changes during the
             menopausal transition",
  author  = "Sowers, Maryfran R and Jannausch, Mary and McConnell, Daniel and
             Little, Roderick and Greendale, Gail A and Finkelstein, Joel S and
             Neer, Robert M and Johnston, Janet and Ettinger, Bruce",
  journal = "J. Clin. Endocrinol. Metab.",
  volume  =  91,
  number  =  4,
  pages   = "1261--1267",
  month   =  apr,
  year    =  2006
}

@ARTICLE{Randolph2004-bk,
  title   = "Change in estradiol and follicle-stimulating hormone across the
             early menopausal transition: effects of ethnicity and age",
  author  = "Randolph, Jr, John F and Sowers, Maryfran and Bondarenko, Irina V
             and Harlow, Siob{\'a}n D and Luborsky, Judith L and Little,
             Roderick J",
  journal = "J. Clin. Endocrinol. Metab.",
  volume  =  89,
  number  =  4,
  pages   = "1555--1561",
  month   =  apr,
  year    =  2004
}

@ARTICLE{Burger1999-pj,
  title   = "Prospectively measured levels of serum follicle-stimulating
             hormone, estradiol, and the dimeric inhibins during the menopausal
             transition in a population-based cohort of women",
  author  = "Burger, H G and Dudley, E C and Hopper, J L and Groome, N and
             Guthrie, J R and Green, A and Dennerstein, L",
  journal = "J. Clin. Endocrinol. Metab.",
  volume  =  84,
  number  =  11,
  pages   = "4025--4030",
  month   =  nov,
  year    =  1999
}

@ARTICLE{Nordin1999-ox,
  title   = "Biochemical variables in pre- and postmenopausal women:
             reconciling the calcium and estrogen hypotheses",
  author  = "Nordin, B E and Need, A G and Morris, H A and Horowitz, M",
  journal = "Osteoporos. Int.",
  volume  =  9,
  number  =  4,
  pages   = "351--357",
  year    =  1999
}

@ARTICLE{Nordin2004-pm,
  title   = "A longitudinal study of bone-related biochemical changes at the
             menopause",
  author  = "Nordin, B E Christopher and WIshart, Judith M and Clifton, Peter M
             and McArthur, Rosemary and Scopacasa, Franca and Need, Allan G and
             Morris, Howard A and O'Loughlin, Peter D and Horowitz, Michael",
  journal = "Clin. Endocrinol.",
  volume  =  61,
  number  =  1,
  pages   = "123--130",
  month   =  jul,
  year    =  2004
}

@ARTICLE{Perrien2006-wy,
  title   = "Bone turnover across the menopause transition: correlations with
             inhibins and follicle-stimulating hormone",
  author  = "Perrien, Daniel S and Achenbach, Sara J and Bledsoe, Samuel E and
             Walser, Brandon and Suva, Larry J and Khosla, Sundeep and Gaddy,
             Dana",
  journal = "J. Clin. Endocrinol. Metab.",
  volume  =  91,
  number  =  5,
  pages   = "1848--1854",
  month   =  may,
  year    =  2006
}

@ARTICLE{Bibbins-Domingo2010-ps,
  title   = "Projected Effect of Dietary Salt Reductions on Future
             Cardiovascular Disease",
  author  = "Bibbins-Domingo, Kirsten and Chertow, Glenn M and Coxson, Pamela G
             and Moran, Andrew and Lightwood, James M and Pletcher, Mark J and
             Goldman, Lee",
  journal = "N. Engl. J. Med.",
  month   =  jan,
  year    =  2010
}

@ARTICLE{Giovannoni2010-mx,
  title   = "A {Placebo-Controlled} Trial of Oral Cladribine for Relapsing
             Multiple Sclerosis",
  author  = "Giovannoni, Gavin and Comi, Giancarlo and Cook, Stuart and
             Rammohan, Kottil and Rieckmann, Peter and Sorenson, Per Soelberg
             and Vermersch, Patrick and Chang, Peter and Hamlett, Anthony and
             Musch, Bruno and Greenberg, Steven J and {the CLARITY Study Group}",
  journal = "N. Engl. J. Med.",
  month   =  jan,
  year    =  2010
}

@ARTICLE{Cohen2010-rq,
  title   = "Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple
             Sclerosis",
  author  = "Cohen, Jeffrey A and Barkhof, Frederik and Comi, Giancarlo and
             Hartung, Hans-Peter and Khatri, Bhupendra and Montalban, Xavier
             and Pelletier, Jean and Capra, Ruggero and Gallo, Paolo and
             Izquierdo, Guillermo and Tiel-Wilck, Klaus and de Vera, Ana and
             Jin, James and Stites, Tracy and Wu, Stacy and Aradhye, Shreeram
             and Kappos, Ludwig and {the TRANSFORMS Study Group}",
  journal = "N. Engl. J. Med.",
  month   =  jan,
  year    =  2010
}

@ARTICLE{Kappos2010-vb,
  title   = "A {Placebo-Controlled} Trial of Oral Fingolimod in Relapsing
             Multiple Sclerosis",
  author  = "Kappos, Ludwig and Radue, Ernst-Wilhelm and O'Connor, Paul and
             Polman, Chris and Hohlfeld, Reinhard and Calabresi, Peter and
             Selmaj, Krzysztof and Agoropoulou, Catherine and Leyk, Malgorzata
             and Zhang-Auberson, Lixin and Burtin, Pascale and {the FREEDOMS
             Study Group}",
  journal = "N. Engl. J. Med.",
  month   =  feb,
  year    =  2010
}

@ARTICLE{Zhang2010-fb,
  title   = "Stochastic modeling and prediction for accrual in clinical trials",
  author  = "Zhang, Xiaoxi and Long, Qi",
  journal = "Stat. Med.",
  month   =  jan,
  year    =  2010
}

@ARTICLE{Soto2010-hw,
  title   = "Semi-mechanistic population pharmacokinetic/pharmacodynamic model
             for neutropenia following therapy with the Plk-1 inhibitor {BI}
             2536 and its application in clinical development",
  author  = "Soto, Elena and Staab, Alexander and Tillmann, Christiane and
             Trommeshauser, Dirk and Fritsch, Holger and Munzert, Gerd and
             Troc{\'o}niz, I{\~n}aki F",
  journal = "Cancer Chemother. Pharmacol.",
  month   =  jan,
  year    =  2010
}

@ARTICLE{Wang2010-pu,
  title   = "Adaptive Bayesian design for phase {I} dose-finding trials using a
             joint model of response and toxicity",
  author  = "Wang, Meihua and Day, Roger",
  journal = "J. Biopharm. Stat.",
  volume  =  20,
  number  =  1,
  pages   = "125--144",
  month   =  jan,
  year    =  2010
}

@ARTICLE{Lehr2010-fs,
  title   = "Quantitative Pharmacology Approach in Alzheimer's Disease:
             Efficacy Modeling of Early Clinical Data to Predict Clinical
             Outcome of Tesofensine",
  author  = "Lehr, Thorsten and Staab, Alexander and Trommeshauser, Dirk and
             Schaefer, Hans Guenter and Kloft, Charlotte",
  journal = "AAPS J.",
  month   =  jan,
  year    =  2010
}

@TECHREPORT{noauthor_2009-dx,
  title       = "A Phase I, {Open-Label}, Randomized, {Multiple-Dose}, 3-Way
                 Crossover Relative Bioavailability Study to Characterize the
                 Pharmacokinetics of 3 Marketed Products Each Containing 200 mg
                 Guaifenesin Under Fasting Conditions in Normal Healthy
                 Subjects (Study report on file)",
  institution = "Reckitt Benckiser Inc.",
  month       =  nov,
  year        =  2009
}

@TECHREPORT{noauthor_2008-ue,
  title       = "A Phase I, {Open-Label}, {Single-Dose}, Randomized, 4-Way
                 Crossover Study Designed to Examine the Effect of the
                 Consumption of a High Fat Meal on the Bioavailability of an
                 Experimental Combination {Extended-Release} Formulation of
                 1200 mg Guaifenesin and 10 mg Hydrocodone Bitartrate in Normal
                 Healthy Subjects Compared to Reference 1200 mg Guaifenesin
                 {Immediate-Release} (as 400 mg Guaifenesin q 4 h) With 15 mg
                 Hycodan\textregistered{} (as 5 mg Hydrocodone Bitartrate q 4
                 h) and to Reference 1200 mg {Extended-Release} Guaifenesin
                 {Bi-Layer} Tablet Product (Mucinex\textregistered{}) With 15
                 mg Hycodan\textregistered{} (as 5 mg Hydrocodone Bitartrate q
                 4 h). Reference 1200 mg Guaifenesin {Immediate-Release} (as
                 400 mg Guaifenesin q 4 h) Will Also be Evaluated in the Fasted
                 State (Study report on file)",
  institution = "Reckitt Benckiser Inc.",
  month       =  aug,
  year        =  2008
}

@TECHREPORT{noauthor_2009-mv,
  title       = "A Study Designed to Examine the Relative Bioavailability of
                 Guaifenesin in a Pediatric Population (Study report on file)",
  institution = "Reckitt Benckiser Inc.",
  month       =  dec,
  year        =  2009
}

@ARTICLE{Bruggeman2007-bg,
  title   = "The nature of systems biology",
  author  = "Bruggeman, Frank J and Westerhoff, Hans V",
  journal = "Trends Microbiol.",
  volume  =  15,
  number  =  1,
  pages   = "45--50",
  month   =  jan,
  year    =  2007
}

@ARTICLE{Bassingthwaighte2009-wo,
  title   = "The Cardiac Physiome: perspectives for the future",
  author  = "Bassingthwaighte, James and Hunter, Peter and Noble, Denis",
  journal = "Exp. Physiol.",
  volume  =  94,
  number  =  5,
  pages   = "597--605",
  month   =  may,
  year    =  2009
}

@PROCEEDINGS{noauthor_2008-cc,
  title = "Quantitative \& Systems Pharmacology Workshop",
  month =  sep,
  year  =  2008
}

@ARTICLE{Anger2008-xt,
  title   = "Translational pharmacology: harnessing increased specialization of
             research within the basic biological sciences",
  author  = "Anger, G J and Piquette-Miller, M",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  83,
  number  =  6,
  pages   = "797--801",
  month   =  jun,
  year    =  2008
}

@ARTICLE{Ravva2010-uw,
  title   = "Quantitative Assessment of {Exposure--Response} Relationships for
             the Efficacy and Tolerability of Varenicline for Smoking Cessation",
  author  = "Ravva, P and Gastonguay, M R and French, J L and Tensfeldt, T G
             and Faessel, H M",
  journal = "Clin. Pharmacol. Ther.",
  number  = "advance online publication",
  month   =  jan,
  year    =  2010
}

@ARTICLE{Farrington1990-cf,
  title   = "Test statistics and sample size formulae for comparative binomial
             trials with null hypothesis of non-zero risk difference or
             non-unity relative risk",
  author  = "Farrington, C P and Manning, G",
  journal = "Stat. Med.",
  volume  =  9,
  number  =  12,
  pages   = "1447--1454",
  month   =  dec,
  year    =  1990
}

@ARTICLE{Lachin1986-bn,
  title   = "Evaluation of sample size and power for analyses of survival with
             allowance for nonuniform patient entry, losses to follow-up,
             noncompliance, and stratification",
  author  = "Lachin, J M and Foulkes, M A",
  journal = "Biometrics",
  volume  =  42,
  number  =  3,
  pages   = "507--519",
  month   =  sep,
  year    =  1986
}

@ARTICLE{Jennison1993-qy,
  title   = "Sequential equivalence testing and repeated confidence intervals,
             with applications to normal and binary responses",
  author  = "Jennison, C and Turnbull, B W",
  journal = "Biometrics",
  volume  =  49,
  number  =  1,
  pages   = "31--43",
  month   =  mar,
  year    =  1993
}

@ARTICLE{Riggs2009-eo,
  title   = "A Systems Biology Model to Describe {Long-Term} Bone Remodeling
             Effects of Estrogen in Menopausal and Postmenopausal Women",
  author  = "Riggs, M M and Peterson, M C and Gastonguay, M R",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  85,
  number  = "Abstract PIII-81",
  pages   = "S93",
  month   =  jan,
  year    =  2009
}

@ARTICLE{De_Winter2009-pf,
  title   = "Pharmacokinetic role of protein binding of mycophenolic acid and
             its glucuronide metabolite in renal transplant recipients",
  author  = "de Winter, Brenda C M and van Gelder, Teun and Sombogaard, Ferdi
             and Shaw, Leslie M and van Hest, Reinier M and Mathot, Ron A A",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  36,
  number  =  6,
  pages   = "541--564",
  month   =  dec,
  year    =  2009
}

@ARTICLE{Chapurlat2000-wg,
  title   = "Longitudinal study of bone loss in pre- and perimenopausal women:
             evidence for bone loss in perimenopausal women",
  author  = "Chapurlat, R D and Garnero, P and Sornay-Rendu, E and Arlot, M E
             and Claustrat, B and Delmas, P D",
  journal = "Osteoporos. Int.",
  volume  =  11,
  number  =  6,
  pages   = "493--498",
  year    =  2000
}

@ARTICLE{Sowers2008-ak,
  title   = "Estradiol rates of change in relation to the final menstrual
             period in a population-based cohort of women",
  author  = "Sowers, Maryfran R and Zheng, Huiyong and McConnell, Daniel and
             Nan, Bin and Harlow, Siob{\'a}n D and Randolph, Jr, John F",
  journal = "J. Clin. Endocrinol. Metab.",
  volume  =  93,
  number  =  10,
  pages   = "3847--3852",
  month   =  oct,
  year    =  2008
}

@ARTICLE{Querfurth2010-vf,
  title   = "Mechanisms of Disease: Alzheimer's Disease",
  author  = "Querfurth, H W and Laferla, Frank M",
  journal = "N. Engl. J. Med.",
  volume  =  362,
  pages   = "394--344",
  month   =  jan,
  year    =  2010
}

@ARTICLE{Riggs2002-qk,
  title   = "Sex steroids and the construction and conservation of the adult
             skeleton",
  author  = "Riggs, B Lawrence and Khosla, Sundeep and Melton, 3rd, L Joseph",
  journal = "Endocr. Rev.",
  volume  =  23,
  number  =  3,
  pages   = "279--302",
  month   =  jun,
  year    =  2002
}

@ARTICLE{Kearns2003-oq,
  title   = "Proton pump inhibitors in pediatrics: relevant pharmacokinetics
             and pharmacodynamics",
  author  = "Kearns, Gregory L and Winter, Harland S",
  journal = "J. Pediatr. Gastroenterol. Nutr.",
  volume  = "37 Suppl 1",
  pages   = "S52--9",
  year    =  2003
}

@ARTICLE{Omari2007-wa,
  title   = "Effect of omeprazole on acid gastroesophageal reflux and gastric
             acidity in preterm infants with pathological acid reflux",
  author  = "Omari, Taher I and Haslam, Ross R and Lundborg, Per and Davidson,
             Geoffrey P",
  journal = "J. Pediatr. Gastroenterol. Nutr.",
  volume  =  44,
  number  =  1,
  pages   = "41--44",
  month   =  jan,
  year    =  2007
}

@ARTICLE{Gallagher2002-us,
  title   = "Effect of discontinuation of estrogen, calcitriol, and the
             combination of both on bone density and bone markers",
  author  = "Gallagher, J Christopher and Rapuri, Prema B and Haynatzki, Gleb
             and Detter, Jeff R",
  journal = "J. Clin. Endocrinol. Metab.",
  volume  =  87,
  number  =  11,
  pages   = "4914--4923",
  month   =  nov,
  year    =  2002
}

@ARTICLE{Lindsay1984-iq,
  title   = "The minimum effective dose of estrogen for prevention of
             postmenopausal bone loss",
  author  = "Lindsay, R and Hart, D M and Clark, D M",
  journal = "Obstet. Gynecol.",
  volume  =  63,
  number  =  6,
  pages   = "759--763",
  month   =  jun,
  year    =  1984
}

@ARTICLE{Lindsay2002-lr,
  title   = "Effect of lower doses of conjugated equine estrogens with and
             without medroxyprogesterone acetate on bone in early
             postmenopausal women",
  author  = "Lindsay, Robert and Gallagher, J Christopher and Kleerekoper,
             Michael and Pickar, James H",
  journal = "JAMA",
  volume  =  287,
  number  =  20,
  pages   = "2668--2676",
  year    =  2002
}

@BOOK{Jennison2000-di,
  title     = "Group sequential methods with applications to clinical trials",
  author    = "Jennison, Christopher and Turnbull, Bruce W",
  publisher = "Chapman \& Hall/CRC",
  year      =  2000,
  address   = "Boca Raton"
}

@TECHREPORT{noauthor_2008-jz,
  title       = "A Phase 2b, Multicenter, Randomized, {Double-Blind}, Parallel,
                 {Placebo-Controlled} Study to Evaluate the Efficacy and Safety
                 of {SUN11031} for Injection Administered Subcutaneously Twice
                 Daily for 12 Weeks to Subjects Having Cachexia Associated with
                 Chronic Obstructive Pulmonary Disease",
  institution = "Asubio",
  month       =  jan,
  year        =  2008
}

@TECHREPORT{noauthor_2005-bk,
  title       = "A Phase 1, Randomized, {Double-Blind}, {Placebo-Controlled},
                 Multiple Ascending Dose Study to Assess the
                 {Safety/Tolerability}, Bioavailability, Pharmacokinetics, and
                 Pharmacodynamics, of {SUN11031} (Synthetic Human Ghrelin)
                 Administered Intravenously as a Bolus or Subcutaneously in
                 Healthy, {Middle-Aged}, {Non-Obese}, Male and Female
                 Volunteers",
  institution = "Asubio",
  month       =  aug,
  year        =  2005
}

@ARTICLE{Cummings2008-rv,
  title   = "Controversies in Alzheimer's disease drug development",
  author  = "Cummings, Jeffrey L",
  journal = "Int. Rev. Psychiatry",
  volume  =  20,
  number  =  4,
  pages   = "389--395",
  month   =  aug,
  year    =  2008
}

@ARTICLE{Cummings2008-pj,
  title   = "Optimizing phase {II} of drug development for disease-modifying
             compounds",
  author  = "Cummings, Jeffrey L",
  journal = "Alzheimers. Dement.",
  volume  =  4,
  number  = "1 Suppl 1",
  pages   = "S15--20",
  month   =  jan,
  year    =  2008
}

@ARTICLE{Leonov2009-en,
  title   = "An adaptive optimal design for the E(max) model and its
             application in clinical trials",
  author  = "Leonov, Sergei and Miller, Sam",
  journal = "J. Biopharm. Stat.",
  volume  =  19,
  number  =  2,
  pages   = "360--385",
  year    =  2009
}

@ARTICLE{Han2009-mt,
  title   = "Informative study designs to identify true parameter-covariate
             relationships",
  author  = "Han, Phey Yen and Kirkpatrick, Carl M J and Green, Bruce",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  36,
  number  =  2,
  pages   = "147--163",
  month   =  apr,
  year    =  2009
}

@INPROCEEDINGS{Anderson2008-rt,
  title       = "Adaptive Designs --- Sample size re-estimation: A review and
                 recommendations",
  booktitle   = "{FDA/Industry} Statistics Workshop",
  author      = "Anderson, Keaven M",
  institution = "Clinical Biostatistics and Research Decision Sciences, Merck
                 Research Laboratories",
  year        =  2008
}

@ARTICLE{Wahlby2002-hp,
  title   = "Comparison of stepwise covariate model building strategies in
             population pharmacokinetic-pharmacodynamic analysis",
  author  = "W{\"a}hlby, Ulrika and Jonsson, E Niclas and Karlsson, Mats O",
  journal = "AAPS PharmSci",
  volume  =  4,
  number  =  4,
  pages   = "E27",
  year    =  2002
}

@ARTICLE{Forsyth2009-ky,
  title   = "Efficient Rehabilitation Trial Designs Using Disease Progress
             Modeling: A Pediatric Traumatic Brain Injury Example",
  author  = "Forsyth, Rob and Vu, Thuy and Salorio, Cynthia and Christensen,
             James and Holford, Nick",
  journal = "Neurorehabil. Neural Repair",
  month   =  dec,
  year    =  2009
}

@ARTICLE{Rohatagi2003-np,
  title   = "Population pharmacokinetics and pharmacodynamics of ciclesonide",
  author  = "Rohatagi, S and Arya, V and Zech, K and Nave, R and Hochhaus, G
             and Jensen, B K and Barrett, J S",
  journal = "J. Clin. Pharmacol.",
  volume  =  43,
  number  =  4,
  pages   = "365--378",
  month   =  apr,
  year    =  2003
}

@ARTICLE{Forsyth2009-ws,
  title   = "Modelling early recovery patterns after paediatric traumatic brain
             injury",
  author  = "Forsyth, Rob J and Salorio, Cynthia F and Christensen, James R",
  journal = "Arch. Dis. Child.",
  month   =  nov,
  year    =  2009
}

@ARTICLE{Manolagas2000-zb,
  title   = "Birth and death of bone cells: basic regulatory mechanisms and
             implications for the pathogenesis and treatment of osteoporosis",
  author  = "Manolagas, S C",
  journal = "Endocr. Rev.",
  volume  =  21,
  number  =  2,
  pages   = "115--137",
  month   =  apr,
  year    =  2000
}

@ARTICLE{Mueck2008-ih,
  title   = "Population pharmacokinetics and pharmacodynamics of once- and
             twice-daily rivaroxaban for the prevention of venous
             thromboembolism in patients undergoing total hip replacement",
  author  = "Mueck, Wolfgang and Borris, Lars C and Dahl, Ola E and Haas,
             Sylvia and Huisman, Menno V and Kakkar, Ajay K and K{\"a}lebo,
             Peter and Muelhofer, Eva and Misselwitz, Frank and Eriksson, Bengt
             I",
  journal = "Thromb. Haemost.",
  volume  =  100,
  number  =  3,
  pages   = "453--461",
  month   =  sep,
  year    =  2008
}

@ARTICLE{Mueck2008-fk,
  title   = "Population pharmacokinetics and pharmacodynamics of
             rivaroxaban--an oral, direct factor Xa inhibitor--in patients
             undergoing major orthopaedic surgery",
  author  = "Mueck, Wolfgang and Eriksson, Bengt I and Bauer, Kenneth A and
             Borris, Lars and Dahl, Ola E and Fisher, William D and Gent,
             Michael and Haas, Sylvia and Huisman, Menno V and Kakkar, Ajay K
             and K{\"a}lebo, Peter and Kwong, Louis M and Misselwitz, Frank and
             Turpie, Alexander G G",
  journal = "Clin. Pharmacokinet.",
  volume  =  47,
  number  =  3,
  pages   = "203--216",
  year    =  2008
}

@ARTICLE{Mueck2007-ad,
  title   = "Population model of the pharmacokinetics and pharmacodynamics of
             rivaroxaban--an oral, direct factor xa inhibitor--in healthy
             subjects",
  author  = "Mueck, W and Becka, M and Kubitza, D and Voith, B and Zuehlsdorf,
             M",
  journal = "Int. J. Clin. Pharmacol. Ther.",
  volume  =  45,
  number  =  6,
  pages   = "335--344",
  month   =  jun,
  year    =  2007
}

@ARTICLE{Sobieraj-Teague2009-zq,
  title   = "New anticoagulants for atrial fibrillation",
  author  = "Sobieraj-Teague, Magdalena and O'Donnell, Martin and Eikelboom,
             John",
  journal = "Semin. Thromb. Hemost.",
  volume  =  35,
  number  =  5,
  pages   = "515--524",
  month   =  jul,
  year    =  2009
}

@ARTICLE{Perzborn2010-oj,
  title   = "Rivaroxaban: A New Oral Factor Xa Inhibitor",
  author  = "Perzborn, Elisabeth and Roehrig, Susanne and Straub, Alexander and
             Kubitza, Dagmar and Mueck, Wolfgang and Laux, Volker",
  journal = "Arterioscler. Thromb. Vasc. Biol.",
  month   =  feb,
  year    =  2010
}

@ARTICLE{Yang2009-su,
  title   = "A Bayesian population {PBPK} model for multiroute chloroform
             exposure",
  author  = "Yang, Yuching and Xu, Xu and Georgopoulos, Panos G",
  journal = "J. Expo. Sci. Environ. Epidemiol.",
  month   =  may,
  year    =  2009
}

@ARTICLE{Seng2008-sm,
  title   = "Physiologically based pharmacokinetic modeling of drug disposition
             in rat and human: a fuzzy arithmetic approach",
  author  = "Seng, Kok-Yong and Nestorov, Ivan and Vicini, Paolo",
  journal = "Pharm. Res.",
  volume  =  25,
  number  =  8,
  pages   = "1771--1781",
  month   =  aug,
  year    =  2008
}

@ARTICLE{Nong2008-xk,
  title   = "Bayesian calibration of a physiologically based
             pharmacokinetic/pharmacodynamic model of carbaryl cholinesterase
             inhibition",
  author  = "Nong, Andy and Tan, Yu-Mei and Krolski, Michael E and Wang,
             Jiansuo and Lunchick, Curt and Conolly, Rory B and Clewell, 3rd,
             Harvey J",
  journal = "J. Toxicol. Environ. Health A",
  volume  =  71,
  number  =  20,
  pages   = "1363--1381",
  year    =  2008
}

@ARTICLE{Chiu2009-kw,
  title   = "Characterizing uncertainty and population variability in the
             toxicokinetics of trichloroethylene and metabolites in mice, rats,
             and humans using an updated database, physiologically based
             pharmacokinetic ({PBPK}) model, and Bayesian approach",
  author  = "Chiu, Weihsueh A and Okino, Miles S and Evans, Marina V",
  journal = "Toxicol. Appl. Pharmacol.",
  volume  =  241,
  number  =  1,
  pages   = "36--60",
  month   =  nov,
  year    =  2009
}

@ARTICLE{Qiu2010-xg,
  title   = "Bayesian analysis of a physiologically based pharmacokinetic model
             for perchloroethylene in humans",
  author  = "Qiu, Junshan and Chien, Yeh-Chung and Bruckner, James V and
             Fisher, Jeffery W",
  journal = "J. Toxicol. Environ. Health A",
  volume  =  73,
  number  =  1,
  pages   = "74--91",
  year    =  2010
}

@ARTICLE{Pery2009-uz,
  title   = "Development of a physiologically based kinetic model for
             99m-Technetium-labelled carbon nanoparticles inhaled by humans",
  author  = "P{\'e}ry, Alexandre R R and Brochot, C{\'e}line and Hoet, Peter H
             M and Nemmar, Abderrahim and Bois, Fr{\'e}d{\'e}ric Y",
  journal = "Inhal. Toxicol.",
  volume  =  21,
  number  =  13,
  pages   = "1099--1107",
  month   =  nov,
  year    =  2009
}

@ARTICLE{Mork2009-ca,
  title   = "Bayesian population analysis of a washin-washout physiologically
             based pharmacokinetic model for acetone",
  author  = "M{\"o}rk, Anna-Karin and Jonsson, Fredrik and Johanson, Gunnar",
  journal = "Toxicol. Appl. Pharmacol.",
  volume  =  240,
  number  =  3,
  pages   = "423--432",
  month   =  nov,
  year    =  2009
}

@ARTICLE{Dokoumetzidis2009-wo,
  title   = "A method for robust model order reduction in pharmacokinetics",
  author  = "Dokoumetzidis, Aristides and Aarons, Leon",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  36,
  number  =  6,
  pages   = "613--628",
  month   =  dec,
  year    =  2009
}

@ARTICLE{Faldum2007-yv,
  title    = "Strategies for Including Patients Recruited During Interim
              Analysis of Clinical Trials",
  author   = "Faldum, Andreas and Hommel, Gerhard",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "1211--1225",
  year     =  2007,
  keywords = "CLINICAL trials, PATIENTS, DATA analysis, PLANNING, RESEARCH,
              Adaptive design, Average sample size, Conditional error function,
              Design modification, Group sequential design, Interim patients,
              Maximum sample size, Overrunning, Power, Repeated interim
              analysis"
}

@ARTICLE{Hung2007-at,
  title    = "Statistical Considerations for Testing Multiple Endpoints in
              Group Sequential or Adaptive Clinical Trials",
  author   = "Hung, H M James and Wang, Sue-Jane and O'Neill, Robert",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "1201--1210",
  year     =  2007,
  keywords = "CLINICAL trials, DRUGS -- Effectiveness, MEDICINE -- Research,
              CLINICAL medicine, MEDICAL model, Adaptive design, Closed
              testing, Flexible design, Group sequential, Primary endpoint,
              Secondary endpoint"
}

@ARTICLE{Shein-Chung2007-vx,
  title    = "Statistical Analysis for {Two-Stage} Seamless Design with
              Different Study Endpoints",
  author   = "Shein-Chung, Chow and Qingshu, Lu and Siu-Keung, Tse",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "1163--1176",
  year     =  2007,
  keywords = "CLINICAL trials, PHARMACEUTICAL industry, PHARMACEUTICAL industry
              -- Research, DRUGS -- Testing, DRUGS -- Effectiveness, Biomarker,
              Sample size allocation, Sample size calculation, Two-stage
              adaptive seamless design"
}

@ARTICLE{Lin2007-py,
  title    = "Seamless Phase {II/III} Combination Study Through Response
              Adaptive Randomization",
  author   = "Lin, Wang and Lu, Cui",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "1177--1187",
  year     =  2007,
  keywords = "DRUGS -- Testing, CLINICAL trials, CLINICAL medicine, MEDICINE --
              Research, CLINICAL trials -- Evaluation, Adaptive randomization,
              Clinical trials, Type I error rate"
}

@ARTICLE{noauthor_2007-zx,
  title    = "Rejoinder",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "1029--1032",
  year     =  2007,
  keywords = "DRUG development, LEONOV, Sergei"
}

@ARTICLE{Zohar2007-id,
  title    = "Recent Developments in Adaptive Designs for Phase {I/II}
              {Dose-Finding} Studies",
  author   = "Zohar, Sarah and Chevret, Sylvie",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "1071--1083",
  year     =  2007,
  keywords = "CLINICAL trials, CANCER -- Treatment, CANCER -- Patients, DRUGS
              -- Dosage, DRUGS -- Administration, Dose-finding, Efficacy, Phase
              I, Phase I/II, Phase II, Toxicity"
}

@ARTICLE{Miller2007-mt,
  title    = "Optimal Designs for Estimating the Interesting Part of a
              {Dose-Effect} Curve",
  author   = "Miller, Frank and Guilbaud, Olivier and Dette, Holger",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "1097--1115",
  year     =  2007,
  keywords = "CLINICAL trials, EXPERIMENTAL design, OPTIMAL designs
              (Statistics), DRUG development, PHARMACOLOGY, Adaptive design,
              Bayesian design, Clinical trial, Dose-finding, Optimal design"
}

@ARTICLE{Bornkamp2007-wh,
  title    = "Innovative Approaches for Designing and Analyzing Adaptive
              {Dose-Ranging} Trials",
  author   = "Bornkamp, Bj{\"o}rn and Bretz, Frank and Dmitrienko, Alex and
              Enas, Greg and Gaydos, Brenda and Chyi-Hung, Hsu and K{\"o}nig,
              Franz and Krams, Michael and Qing, Liu and Neuenschwander, Beat
              and Parke, Tom and Pinheiro, Jos{\'e} and Roy, Amit and Sax, Rick
              and Shen, Frank",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "965--995",
  year     =  2007,
  keywords = "DRUGS, DRUGS -- Research, DRUG development, PHARMACOLOGY,
              PHARMACY, Dose-finding, Dose-response, Flexible designs,
              Modeling, Phase II trials, Proof of concept, Target dose"
}

@ARTICLE{Pong2007-zg,
  title    = "{Guest-Editor's} Note: ``Statistical Issues in Adaptive Design
              Methods in Clinical Trials''",
  author   = "Pong, Annpey",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "1133--1134",
  year     =  2007,
  keywords = "EDITORIALS, CLINICAL trials, CLINICAL medicine, DRUG development,
              PHARMACOLOGY"
}

@ARTICLE{Dragalin2007-ug,
  title    = "Guest Editorial - Statistical Issues in Adaptive Design Methods
              in Clinical Trials",
  author   = "Dragalin, Vladimir",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "955--956",
  year     =  2007,
  keywords = "EDITORIALS, DRUG development, CLINICAL trials, CLINICAL medicine,
              PHARMACOLOGY"
}

@ARTICLE{Weir2007-ei,
  title    = "Flexible Design and Efficient Implementation of Adaptive
              {Dose-Finding} Studies",
  author   = "Weir, Christopher J and Spiegelhalter, David J and Grieve, Andrew
              P",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "1033--1050",
  year     =  2007,
  keywords = "CLINICAL trials, MEDICINE -- Research, HUMAN experimentation in
              medicine, MEDICAL ethics, MEDICINE, Experimental, Acute stroke,
              Bayesian adaptive design, Markov chain Monte Carlo, Normal
              dynamic linear model"
}

@ARTICLE{Fedorov2007-vw,
  title    = "Dose Finding Designs for Continuous Responses and Binary Utility",
  author   = "Fedorov, Valerii V and Yuehui, Wu",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "1085--1096",
  year     =  2007,
  keywords = "CLINICAL trials, DRUGS -- Testing, PROBABILITIES, OPTIMAL designs
              (Statistics), EXPERIMENTAL design, Binary utility function,
              Continuous responses, Dichotomization, Optimal study design,
              Two-stage design"
}

@ARTICLE{Hemmings2007-fc,
  title    = "Discussion of ``The White Paper of the {PhRMA} Working Group on
              Adaptive {Dose-Ranging} Designs''",
  author   = "Hemmings, Robert",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "1021--1027",
  year     =  2007,
  keywords = "EDITORIALS, CLINICAL trials, DRUGS -- Dosage, DRUGS --
              Administration, GREAT Britain"
}

@ARTICLE{Sue-Jane2007-br,
  title    = "Discussion of the ``White Paper of the {PhRMA} Working Group on
              Adaptive {Dose-Ranging} Designs''",
  author   = "Sue-Jane, Wang",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "1015--1020",
  year     =  2007,
  keywords = "DRUGS -- Dosage, DRUG development, DRUGS -- Dose-response
              relationship, SIMULATION methods, CLINICAL trials, PHARMACOLOGY"
}

@ARTICLE{Grieve2007-wb,
  title    = "Discussion of the ``White Paper of the {PhRMA} Working Group on
              Adaptive {Dose-Ranging} Designs''",
  author   = "Grieve, A P",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "997--1004",
  year     =  2007,
  keywords = "DRUGS -- Dose-response relationship, DRUG development, SIMULATION
              methods, CLINICAL trials, PHARMACOLOGY"
}

@ARTICLE{Leonov2007-af,
  title    = "Discussion of the ``White Paper of the {PhRMA} {PISC} Working
              Group on Adaptive {Dose-Ranging} Designs''",
  author   = "Leonov, Sergei",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "1013--1014",
  year     =  2007,
  keywords = "DRUGS -- Dose-response relationship, PHARMACOLOGY"
}

@ARTICLE{Burman2007-lk,
  title    = "Discussion of the Paper ``Adaptive {Dose-Ranging} Designs''",
  author   = "Burman, Carl-Fredrik",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "1005--1011",
  year     =  2007,
  keywords = "EDITORIALS, EXPERIMENTAL design, DRUGS -- Dose-response
              relationship, SIMULATION methods, PHARMACOLOGY"
}

@ARTICLE{Chang2007-th,
  title    = "Analysis Strategies for Adaptive Designs with Multiple Endpoints",
  author   = "Chang, Mark and Shein-Chung, Chow",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "1189--1200",
  year     =  2007,
  keywords = "RESEARCH, DATA analysis, STRATEGY, STATISTICS, MODEL validation,
              Adaptive design with multiple endpoints, Closed testing
              procedure, Fractal gatekeeper procedure, Gatekeeper procedure,
              Multiplicity"
}

@ARTICLE{Jennison2007-dq,
  title    = "Adaptive Seamless Designs: Selection and Prospective Testing of
              Hypotheses",
  author   = "Jennison, Christopher and Turnbull, Bruce W",
  journal  = "J. Biopharm. Stat.",
  volume   =  17,
  number   =  6,
  pages    = "1135--1161",
  year     =  2007,
  keywords = "HYPOTHESIS, MEDICAL protocols, DRUGS -- Dosage, DRUGS -- Testing,
              CLINICAL pharmacology, Adaptive designs, Clinical trials, Closure
              principle, Combination tests, Early data review, Enrichment
              designs, Flexible design, Group sequential tests, Interim
              analysis, Meta-analysis, Multiple testing, Non-inferiority
              testing, Nuisance parameters, Phase II/III designs, Sample size
              re-estimation, Seamless designs, Targeted designs, Two-stage
              procedure, Variance spending"
}

@ARTICLE{Huaibao2007-rf,
  title    = "Adaptive Group Sequential Test for Clinical Trials with Changing
              Patient Population",
  author   = "Huaibao, Feng and Jun, Shao and Shein-Chung, Chow",

repository: yonicd/paperpile

repo_name: yonicd/paperpile