text:
,
  number  =  4,
  pages   = "456--458",
  year    =  2004
}

@ARTICLE{De_Wildt2003-qq,
  title   = "Population pharmacokinetics and metabolism of midazolam in
             pediatric intensive care patients",
  author  = "de Wildt, S N and de Hoog, M and Vinks, A A and Van der, Giesen E
             and van den Anker, J N",
  journal = "Crit. Care Med.",
  volume  =  31,
  number  =  7,
  pages   = "1952--1958",
  year    =  2003
}

@ARTICLE{Eriksson2003-to,
  title   = "Pharmacokinetics of melagatran and the effect on ex vivo
             coagulation time in orthopaedic surgery patients receiving
             subcutaneous melagatran and oral ximelagatran: a population model
             analysis",
  author  = "Eriksson, U G and Mandema, J W and Karlsson, M O and Frison, L and
             Gisleskog, P O and Wahlby, U and Hamren, B and Gustafsson, D and
             Eriksson, B I",
  journal = "Clin. Pharmacokinet.",
  volume  =  42,
  number  =  7,
  pages   = "687--701",
  year    =  2003
}

@ARTICLE{Ette2004-wl,
  title   = "Population Pharmacokinetics {II}: Estimation Methods",
  author  = "Ette, E I and Williams, P J",
  journal = "Ann. Pharmacother.",
  volume  =  38,
  number  =  11,
  pages   = "1907--1915",
  year    =  2004
}

@ARTICLE{Ette2004-tz,
  title   = "Population pharmacokinetics I: background, concepts, and models",
  author  = "Ette, E I and Williams, P J",
  journal = "Ann. Pharmacother.",
  volume  =  38,
  number  =  10,
  pages   = "1702--1706",
  year    =  2004
}

@ARTICLE{Furuya2003-vv,
  title   = "Comparison of stepwise and simultaneous estimations of population
             pharmacokinetics and pharmacodynamics of {TS-943}",
  author  = "Furuya, A and Kato, N and Jingu, S and Akimoto, M and Kasai, O and
             Suwa, T and Sato, M and Ogata, H",
  journal = "Eur. J. Drug Metab. Pharmacokinet.",
  volume  =  28,
  number  =  3,
  pages   = "191--199",
  year    =  2003
}

@ARTICLE{Gregoire2004-zw,
  title   = "Population pharmacokinetics of Ibuprofen enantiomers in very
             premature neonates",
  author  = "Gregoire, N and Gualano, V and Geneteau, A and Millerioux, L and
             Brault, M and Mignot, A and Roze, J C",
  journal = "J. Clin. Pharmacol.",
  volume  =  44,
  number  =  10,
  pages   = "1114--1124",
  year    =  2004
}

@ARTICLE{Jacobson2003-ct,
  title   = "Posttransplant day significantly influences pharmacokinetics of
             cyclosporine after hematopoietic stem cell transplantation",
  author  = "Jacobson, P A and Ng, J and Green, K G and Rogosheske, J and
             Brundage, R",
  journal = "Biol. Blood Marrow Transplant.",
  volume  =  9,
  number  =  5,
  pages   = "304--311",
  year    =  2003
}

@ARTICLE{Jonsson2003-lf,
  title   = "Population pharmacokinetics of levosimendan in patients with
             congestive heart failure",
  author  = "Jonsson, E N and Antila, S and McFadyen, L and Lehtonen, L and
             Karlsson, M O",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  55,
  number  =  6,
  pages   = "544--551",
  year    =  2003
}

@ARTICLE{Lee2003-ud,
  title   = "Population pharmacokinetic and pharmacodynamic modeling of
             etanercept using logistic regression analysis",
  author  = "Lee, H and Kimko, H C and Rogge, M and Wang, D and Nestorov, I and
             Peck, C C",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  73,
  number  =  4,
  pages   = "348--365",
  year    =  2003
}

@ARTICLE{Lindbom2004-bh,
  title   = "{Perl-speaks-NONMEM} ({PsN)--a} Perl module for {NONMEM} related
             programming",
  author  = "Lindbom, L and Ribbing, J and Jonsson, E N",
  journal = "Comput. Methods Programs Biomed.",
  volume  =  75,
  number  =  2,
  pages   = "85--94",
  year    =  2004
}

@ARTICLE{Mulla2003-qi,
  title   = "Population pharmacokinetics of theophylline during paediatric
             extracorporeal membrane oxygenation",
  author  = "Mulla, H and Nabi, F and Nichani, S and Lawson, G and Firmin, R K
             and Upton, D R",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  55,
  number  =  1,
  pages   = "23--31",
  year    =  2003
}

@ARTICLE{Nguyen2004-ng,
  title   = "{I.V}. busulfan in pediatrics: a novel dosing to improve
             safety/efficacy for hematopoietic progenitor cell transplantation
             recipients",
  author  = "Nguyen, L and Fuller, D and Lennon, S and Leger, F and Puozzo, C",
  journal = "Bone Marrow Transplant.",
  volume  =  33,
  number  =  10,
  pages   = "979--987",
  year    =  2004
}

@ARTICLE{Panetta2003-pa,
  title   = "Population pharmacokinetics of temozolomide and metabolites in
             infants and children with primary central nervous system tumors",
  author  = "Panetta, J C and Kirstein, M N and Gajjar, A and Nair, G and
             Fouladi, M and Heideman, R L and Wilkinson, M and Stewart, C F",
  journal = "Cancer Chemother. Pharmacol.",
  volume  =  52,
  number  =  6,
  pages   = "435--441",
  year    =  2003
}

@ARTICLE{Payen2003-zq,
  title   = "Population pharmacokinetics of ciprofloxacin in pediatric and
             adolescent patients with acute infections",
  author  = "Payen, S and Serreau, R and Munck, A and Aujard, Y and Aigrain, Y
             and Bressolle, F and Jacqz-Aigrain, E",
  journal = "Antimicrob. Agents Chemother.",
  volume  =  47,
  number  =  10,
  pages   = "3170--3178",
  year    =  2003
}

@ARTICLE{Petersen2003-ja,
  title   = "Population pharmacokinetics of prednisolone in children with acute
             lymphoblastic leukemia",
  author  = "Petersen, K B and Jusko, W J and Rasmussen, M and Schmiegelow, K",
  journal = "Cancer Chemother. Pharmacol.",
  volume  =  51,
  number  =  6,
  pages   = "465--473",
  year    =  2003
}

@ARTICLE{Pfister2004-xt,
  title   = "Optimizing dose selection with modeling and simulation:
             application to the vasopeptidase inhibitor {M100240}",
  author  = "Pfister, M and Martin, N E and Haskell, L P and Barrett, J S",
  journal = "J. Clin. Pharmacol.",
  volume  =  44,
  number  =  6,
  pages   = "621--631",
  year    =  2004
}

@ARTICLE{Pollak2004-mr,
  title   = "Use of population modeling to define rational monitoring of
             amiodarone hepatic effects",
  author  = "Pollak, P T and Shafer, S L",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  75,
  number  =  4,
  pages   = "342--351",
  year    =  2004
}

@ARTICLE{Port2004-ta,
  title   = "Recombinant human erythropoietin for the treatment of renal
             anaemia in children: no justification for bodyweight-adjusted
             dosage",
  author  = "Port, R E and Kiepe, D and Van Guilder, M and Jelliffe, R W and
             Mehls, O",
  journal = "Clin. Pharmacokinet.",
  volume  =  43,
  number  =  1,
  pages   = "57--70",
  year    =  2004
}

@ARTICLE{Sallas2003-pr,
  title   = "Pharmacokinetic drug interactions in children taking oxcarbazepine",
  author  = "Sallas, W M and Milosavljev, S and D'Souza, J and Hossain, M",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  74,
  number  =  2,
  pages   = "138--149",
  year    =  2003
}

@ARTICLE{Smyth2004-wo,
  title   = "Intravenous indometacin in preterm infants with symptomatic patent
             ductus arteriosus. A population pharmacokinetic study",
  author  = "Smyth, J M and Collier, P S and Darwish, M and Millership, J S and
             Halliday, H L and Petersen, S and McElnay, J C",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  58,
  number  =  3,
  pages   = "249--258",
  year    =  2004
}

@ARTICLE{Soy2003-qn,
  title   = "Population pharmacokinetics of enfuvirtide in pediatric patients
             with human immunodeficiency virus: searching for exposure-response
             relationships",
  author  = "Soy, D and Aweeka, F T and Church, J A and Cunningham, C K and
             Palumbo, P and Kosel, B W and Sheiner, L B",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  74,
  number  =  6,
  pages   = "569--580",
  year    =  2003
}

@ARTICLE{Tornoe2004-fr,
  title   = "Non-linear mixed-effects pharmacokinetic/pharmacodynamic modelling
             in {NLME} using differential equations",
  author  = "Tornoe, C W and Agerso, H and Jonsson, E N and Madsen, H and
             Nielsen, H A",
  journal = "Comput. Methods Programs Biomed.",
  volume  =  76,
  number  =  1,
  pages   = "31--40",
  year    =  2004
}

@ARTICLE{Yates2003-xk,
  title   = "The effect of {CYP3A5} and {MDR1} polymorphic expression on
             cyclosporine oral disposition in renal transplant patients",
  author  = "Yates, C R and Zhang, W and Song, P and Li, S and Gaber, A O and
             Kotb, M and Honaker, M R and Alloway, R R and Meibohm, B",
  journal = "J. Clin. Pharmacol.",
  volume  =  43,
  number  =  6,
  pages   = "555--564",
  year    =  2003
}

@ARTICLE{Zingmark2003-dm,
  title   = "Population pharmacokinetics of clomethiazole and its effect on the
             natural course of sedation in acute stroke patients",
  author  = "Zingmark, P H and Ekblom, M and Odergren, T and Ashwood, T and
             Lyden, P and Karlsson, M O and Jonsson, E N",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  56,
  number  =  2,
  pages   = "173--183",
  year    =  2003
}

@ARTICLE{Zingmark2004-jq,
  title   = "Pharmacokinetic/pharmacodynamic models for the depletion of
             Vbeta5.2/5.3 {T} cells by the monoclonal antibody {ATM-027} in
             patients with multiple sclerosis, as measured by {FACS}",
  author  = "Zingmark, P H and Edenius, C and Karlsson, M O",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  58,
  number  =  4,
  pages   = "378--389",
  year    =  2004
}

@ARTICLE{Doufas2004-fw,
  title   = "Induction Speed Is Not a Determinant of Propofol Pharmacodynamics",
  author  = "Doufas, A G and Bakhshandeh, M and Bjorksten, A R and Shafer, S L
             and Sessler, D I",
  journal = "Anesthesiology",
  volume  =  101,
  number  =  5,
  pages   = "1112--1121",
  year    =  2004
}

@ARTICLE{Lodise2004-zx,
  title   = "Pharmacodynamic profiling of piperacillin in the presence of
             tazobactam in patients through the use of population
             pharmacokinetic models and Monte Carlo simulation",
  author  = "Lodise, T. P., Jr and Lomaestro, B and Rodvold, K A and Danziger,
             L H and Drusano, G L",
  journal = "Antimicrob. Agents Chemother.",
  volume  =  48,
  number  =  12,
  pages   = "4718--4724",
  year    =  2004
}

@ARTICLE{Ambrose2003-kl,
  title   = "Gatifloxacin and the elderly: pharmacokinetic-pharmacodynamic
             rationale for a potential age-related dose reduction",
  author  = "Ambrose, P G and Bhavnani, S M and Cirincione, B B and Piedmonte,
             M and Grasela, T H",
  journal = "J. Antimicrob. Chemother.",
  volume  =  52,
  number  =  3,
  pages   = "435--440",
  year    =  2003
}

@ARTICLE{Yu2003-gw,
  title   = "Prediction of clinical responses in a simulated phase {III} trial
             of Crohn's patients administered the antisense phosphorothioate
             oligonucleotide {ISIS} 2302: comparison of proposed dosing
             regimens",
  author  = "Yu, R Z and Su, J Q and Grundy, J S and Geary, R S and Sewell, K L
             and Dorr, A and Levin, A A",
  journal = "Antisense Nucleic Acid Drug Dev.",
  volume  =  13,
  number  =  1,
  pages   = "57--66",
  year    =  2003
}

@ARTICLE{Kowalski2001-dc,
  title   = "Efficient screening of covariates in population models using
             Wald's approximation to the likelihood ratio test",
  author  = "Kowalski, K G and Hutmacher, M M",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  28,
  number  =  3,
  pages   = "253--275",
  year    =  2001
}

@ARTICLE{Drover2002-gv,
  title   = "Input characteristics and bioavailability after administration of
             immediate and a new extended-release formulation of hydromorphone
             in healthy volunteers",
  author  = "Drover, D R and Angst, M S and Valle, M and Ramaswamy, B and
             Naidu, S and Stanski, D R and Verotta, D",
  journal = "Anesthesiology",
  volume  =  97,
  number  =  4,
  pages   = "827--836",
  year    =  2002
}

@ARTICLE{Gastonguay2004-hl,
  title   = "A full model estimation approach for covariate effects: Inference
             based on clinical importance and estimation precision",
  author  = "Gastonguay, M R",
  journal = "AAPS J.",
  volume  =  6,
  number  = "S1",
  pages   = "W4354",
  year    =  2004
}

@ARTICLE{Cross2002-pr,
  title   = "Postmarketing drug dosage changes of 499 {FDA-approved} new
             molecular entities, 1980-1999",
  author  = "Cross, J and Lee, H and Westelinck, A and Nelson, J and
             Grudzinskas, C and Peck, C",
  journal = "Pharmacoepidemiol. Drug Saf.",
  volume  =  11,
  number  =  6,
  pages   = "439--446",
  year    =  2002
}

@ARTICLE{Galluppi2001-vm,
  title   = "Integration of pharmacokinetic and pharmacodynamic studies in the
             discovery, development, and review of protein therapeutic agents:
             a conference report",
  author  = "Galluppi, G R and Rogge, M C and Roskos, L K and Lesko, L J and
             Green, M D and Feigal, D. W., Jr and Peck, C C",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  69,
  number  =  6,
  pages   = "387--399",
  year    =  2001
}

@ARTICLE{Holford2000-tz,
  title   = "Simulation of clinical trials",
  author  = "Holford, N H and Kimko, H C and Monteleone, J P and Peck, C C",
  journal = "Annu. Rev. Pharmacol. Toxicol.",
  volume  =  40,
  pages   = "209--234",
  year    =  2000
}

@ARTICLE{Peck1997-ij,
  title   = "Drug development: improving the process",
  author  = "Peck, C C",
  journal = "Food Drug Law J.",
  volume  =  52,
  number  =  2,
  pages   = "163--167",
  year    =  1997
}

@ARTICLE{noauthor_2001-do,
  title   = "Biomarkers and surrogate endpoints: preferred definitions and
             conceptual framework",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  69,
  number  =  3,
  pages   = "89--95",
  year    =  2001
}

@ARTICLE{Krall1998-pw,
  title   = "Clinical trial modeling and siumlation - Warner {KE}, Peck {CC},
             Work in Progress",
  author  = "Krall, R L and Engleman, K H and Ko, H C and Peck, C C",
  journal = "Drug Inf. J.",
  volume  =  32,
  pages   = "971--976",
  year    =  1998
}

@ARTICLE{Holford2001-ma,
  title   = "Target concentration intervention: beyond {Y2K}",
  author  = "Holford, N H",
  journal = "Br. J. Clin. Pharmacol.",
  volume  = "52 Suppl 1",
  pages   = "55S--59S",
  year    =  2001
}

@ARTICLE{Matthews2004-wr,
  title   = "Quantitative justification for target concentration
             intervention--parameter variability and predictive performance
             using population pharmacokinetic models for aminoglycosides",
  author  = "Matthews, I and Kirkpatrick, C and Holford, N",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  58,
  number  =  1,
  pages   = "8--19",
  year    =  2004
}

@ARTICLE{Bekker2004-fd,
  title   = "A single-dose placebo-controlled study of {AMG} 162, a fully human
             monoclonal antibody to {RANKL}, in postmenopausal women",
  author  = "Bekker, P J and Holloway, D L and Rasmussen, A S and Murphy, R and
             Martin, S W and Leese, P T and Holmes, G B and Dunstan, C R and
             DePaoli, A M",
  journal = "J. Bone Miner. Res.",
  volume  =  19,
  number  =  7,
  pages   = "1059--1066",
  year    =  2004
}

@ARTICLE{Blair2004-ul,
  title   = "Population pharmacokinetics of raltitrexed in patients with
             advanced solid tumours",
  author  = "Blair, E Y and Rivory, L P and Clarke, S J and McLachlan, A J",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  57,
  number  =  4,
  pages   = "416--426",
  year    =  2004
}

@ARTICLE{Bonate2004-dt,
  title   = "Population pharmacokinetics of {APOMINE}: a meta-analysis in
             cancer patients and healthy males",
  author  = "Bonate, P L and Floret, S and Bentzen, C",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  58,
  number  =  2,
  pages   = "142--155",
  year    =  2004
}

@ARTICLE{Gex-Fabry2000-on,
  title   = "Population pharmacokinetics of clomipramine,
             desmethylclomipramine, and hydroxylated metabolites in patients
             with depression receiving chronic treatment: model evaluation",
  author  = "Gex-Fabry, M and Haffen, E and Paintaud, G and Bizouard, P and
             Sechter, D and Bechtel, P R and Balant, L P",
  journal = "Ther. Drug Monit.",
  volume  =  22,
  number  =  6,
  pages   = "701--711",
  year    =  2000
}

@ARTICLE{Ishibashi2003-dj,
  title   = "Population pharmacokinetics of platinum after nedaplatin
             administration and model validation in adult patients",
  author  = "Ishibashi, T and Yano, Y and Oguma, T",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  56,
  number  =  2,
  pages   = "205--213",
  year    =  2003
}

@ARTICLE{Mougenot2004-xv,
  title   = "Population pharmacokinetics of melphalan, infused over a 24-hour
             period, in patients with advanced malignancies",
  author  = "Mougenot, P and Pinguet, F and Fabbro, M and Culine, S and Poujol,
             S and Astre, C and Bressolle, F",
  journal = "Cancer Chemother. Pharmacol.",
  volume  =  53,
  number  =  6,
  pages   = "503--512",
  year    =  2004
}

@ARTICLE{Rajagopalan2003-pi,
  title   = "Population pharmacokinetics of ciprofloxacin in pediatric patients",
  author  = "Rajagopalan, P and Gastonguay, M R",
  journal = "J. Clin. Pharmacol.",
  volume  =  43,
  number  =  7,
  pages   = "698--710",
  year    =  2003
}

@ARTICLE{Sun1999-ah,
  title   = "Population pharmacokinetics. A regulatory perspective",
  author  = "Sun, H and Fadiran, E O and Jones, C D and Lesko, L and Huang, S M
             and Higgins, K and Hu, C and Machado, S and Maldonado, S and
             Williams, R and Hossain, M and Ette, E I",
  journal = "Clin. Pharmacokinet.",
  volume  =  37,
  number  =  1,
  pages   = "41--58",
  year    =  1999
}

@ARTICLE{Williams2000-qs,
  title   = "The role of population pharmacokinetics in drug development in
             light of the Food and Drug Administration's 'Guidance for
             Industry: population pharmacokinetics'",
  author  = "Williams, P J and Ette, E I",
  journal = "Clin. Pharmacokinet.",
  volume  =  39,
  number  =  6,
  pages   = "385--395",
  year    =  2000
}

@ARTICLE{Bouwmeester2004-kf,
  title   = "Developmental pharmacokinetics of morphine and its metabolites in
             neonates, infants and young children",
  author  = "Bouwmeester, N J and Anderson, B J and Tibboel, D and Holford, N H",
  journal = "Br. J. Anaesth.",
  volume  =  92,
  number  =  2,
  pages   = "208--217",
  year    =  2004
}

@ARTICLE{McCarver2002-wx,
  title   = "The ontogeny of human drug-metabolizing enzymes: phase {II}
             conjugation enzymes and regulatory mechanisms",
  author  = "McCarver, D G and Hines, R N",
  journal = "J. Pharmacol. Exp. Ther.",
  volume  =  300,
  number  =  2,
  pages   = "361--366",
  year    =  2002
}

@ARTICLE{Strassburg2002-el,
  title   = "Developmental aspects of human hepatic drug glucuronidation in
             young children and adults",
  author  = "Strassburg, C P and Strassburg, A and Kneip, S and Barut, A and
             Tukey, R H and Rodeck, B and Manns, M P",
  journal = "Gut",
  volume  =  50,
  number  =  2,
  pages   = "259--265",
  year    =  2002
}

@ARTICLE{Sargent1998-mf,
  title   = "Verification and validation of simulation models",
  author  = "Sargent, R G",
  journal = "Proc. of 1998 Winter Simulation Conference",
  pages   = "121--130",
  year    =  1998
}

@ARTICLE{Mould2002-wt,
  title   = "Population pharmacokinetic and adverse event analysis of topotecan
             in patients with solid tumors",
  author  = "Mould, D R and Holford, N H and Schellens, J H and Beijnen, J H
             and Hutson, P R and Rosing, H and Bokkel Huinink, W W and
             Rowinsky, E K and Schiller, J H and Russo, M and Ross, G",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  71,
  number  =  5,
  pages   = "334--348",
  year    =  2002
}

@INCOLLECTION{Gelman1995-bp,
  title     = "Model checking and sensitivity analysis",
  booktitle = "Bayesian data analysis",
  author    = "Gelman, A and Carlin, J B and Stern, H S and Rubin, D B",
  publisher = "Chapman \& Hall",
  year      =  1995,
  address   = "New York"
}

@INCOLLECTION{Box1979-ka,
  title     = "Robustness in the strategy of scientific model building",
  booktitle = "Robustness in Statistics",
  author    = "Box, G E P and Launer, R L and Wilkinson, G N",
  publisher = "Academic Press",
  year      =  1979,
  address   = "New York"
}

@INCOLLECTION{Mentre1997-pz,
  title     = "Validation of population pharmacokinetic/pharmacodynamic
               analyses: Review of proposed approaches",
  booktitle = "The population approach: Measuring and managing variability in
               response, concentration and dose",
  author    = "Mentre, F and Ebelin, M E and Aarons, L and Balant, L P and
               Danhof, M and Gex-Fabry, M and Gundert-Remy, U A and Karlsson, M
               O and Morselli, P L and Rombout, F and Rowland, M and Steimer, J
               L and Vozeh, S",
  publisher = "COST",
  year      =  1997,
  address   = "Brussels"
}

@MISC{Hastie_undated-ph,
  title  = "Modern regression and classification short course",
  author = "Hastie, T and Tibshirani, R",
  month  =  1998
}

@MISC{noauthor_undated-lm,
  title = "Randomization test"
}

@ARTICLE{Mould1999-wz,
  title   = "A population pharmacokinetic-pharmacodynamic analysis of single
             doses of clenoliximab in patients with rheumatoid arthritis",
  author  = "Mould, D R and Davis, C B and Minthorn, E A and Kwok, D C and
             Elliott, M J and Luggen, M E and Totoritis, M C",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  66,
  number  =  3,
  pages   = "246--257",
  year    =  1999
}

@ARTICLE{Nieforth1996-ap,
  title   = "Use of an indirect pharmacodynamic stimulation model of {MX}
             protein induction to compare in vivo activity of interferon
             alfa-2a and a polyethylene glycol-modified derivative in healthy
             subjects",
  author  = "Nieforth, K A and Nadeau, R and Patel, I H and Mould, D",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  59,
  number  =  6,
  pages   = "636--646",
  year    =  1996
}

@ARTICLE{Krzyzanski1999-fj,
  title   = "Basic pharmacodynamic models for agents that alter production of
             natural cells",
  author  = "Krzyzanski, W and Ramakrishnan, R and Jusko, W J",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  27,
  number  =  5,
  pages   = "467--489",
  year    =  1999
}

@ARTICLE{Krzyzanski2002-kq,
  title   = "Multiple-pool cell lifespan model of hematologic effects of
             anticancer agents",
  author  = "Krzyzanski, W and Jusko, W J",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  29,
  number  =  4,
  pages   = "311--337",
  year    =  2002
}

@ARTICLE{Ette2004-uc,
  title   = "Population pharmacokinetics {III}: design, analysis, and
             application of population pharmacokinetic Studies",
  author  = "Ette, E I and Williams, P J and Lane, J R",
  journal = "Ann. Pharmacother.",
  volume  =  38,
  number  =  12,
  pages   = "2136--2144",
  year    =  2004
}

@ARTICLE{Altman1989-qo,
  title   = "Bootstrap investigation of the stability of a Cox regression model",
  author  = "Altman, D G and Andersen, P K",
  journal = "Stat. Med.",
  volume  =  8,
  number  =  7,
  pages   = "771--783",
  year    =  1989
}

@ARTICLE{Copas1997-he,
  title   = "Using regression models for prediction: shrinkage and regression
             to the mean",
  author  = "Copas, J B",
  journal = "Stat. Methods Med. Res.",
  volume  =  6,
  number  =  2,
  pages   = "167--183",
  year    =  1997
}

@ARTICLE{Copas1983-xx,
  title   = "Regression, prediction and shrinkage (with discussion)",
  author  = "Copas, J B",
  journal = "J. R. Stat. Soc. Series B Stat. Methodol.",
  volume  =  45,
  pages   = "311--354",
  year    =  1983
}

@ARTICLE{Kjellsson2004-kr,
  title   = "The back-step method -- method for obtaining unbiased population
             parameter estimates for ordered categorical data",
  author  = "Kjellsson, M C and J{\^\i}nsson, S and Karlsson, M O",
  journal = "AAPS J.",
  volume  =  6,
  number  =  3,
  pages   = "1--10",
  year    =  2004
}

@ARTICLE{Bonate2004-vz,
  title   = "Population pharmacokinetics of clofarabine, a second-generation
             nucleoside analog, in pediatric patients with acute leukemia",
  author  = "Bonate, P L and Craig, A and Gaynon, P and Gandhi, V and Jeha, S
             and Kadota, R and Lam, G N and Plunkett, W and Razzouk, B and
             Rytting, M and Steinherz, P and Weitman, S",
  journal = "J. Clin. Pharmacol.",
  volume  =  44,
  number  =  11,
  pages   = "1309--1322",
  year    =  2004
}

@ARTICLE{Boni2005-wq,
  title   = "Population pharmacokinetics of {CCI-779}: correlations to safety
             and pharmacogenomic responses in patients with advanced renal
             cancer",
  author  = "Boni, J P and Leister, C and Bender, G and Fitzpatrick, V and
             Twine, N and Stover, J and Dorner, A and Immermann, F and
             Burczynski, M E",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  77,
  number  =  1,
  pages   = "76--89",
  year    =  2005
}

@ARTICLE{Bourgoin2005-wo,
  title   = "Bayesian estimation of cyclosporin exposure for routine
             therapeutic drug monitoring in kidney transplant patients",
  author  = "Bourgoin, H and Paintaud, G and Buchler, M and Lebranchu, Y and
             Autret-Leca, E and Mentre, F and Le Guellec, C",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  59,
  number  =  1,
  pages   = "18--27",
  year    =  2005
}

@ARTICLE{Chakraborty2005-em,
  title   = "Population pharmacokinetics of erythropoietin in critically ill
             subjects",
  author  = "Chakraborty, A and Natarajan, J and Guilfoyle, M and Morgan, N and
             Vercammen, E and Cheung, W",
  journal = "J. Clin. Pharmacol.",
  volume  =  45,
  number  =  2,
  pages   = "193--202",
  year    =  2005
}

@ARTICLE{Dahan2004-qn,
  title   = "Simultaneous measurement and integrated analysis of analgesia and
             respiration after an intravenous morphine infusion",
  author  = "Dahan, A and Romberg, R and Teppema, L and Sarton, E and Bijl, H
             and Olofsen, E",
  journal = "Anesthesiology",
  volume  =  101,
  number  =  5,
  pages   = "1201--1209",
  year    =  2004
}

@ARTICLE{Duffull2005-uz,
  title   = "Analysis of population pharmacokinetic data using {NONMEM} and
             {WinBUGS}",
  author  = "Duffull, S B and Kirkpatrick, C M and Green, B and Holford, N H",
  journal = "J. Biopharm. Stat.",
  volume  =  15,
  number  =  1,
  pages   = "53--73",
  year    =  2005
}

@ARTICLE{Hesselink2004-ob,
  title   = "Population pharmacokinetics of cyclosporine in kidney and heart
             transplant recipients and the influence of ethnicity and genetic
             polymorphisms in the {MDR-1}, {CYP3A4}, and {CYP3A5} genes",
  author  = "Hesselink, D A and van Gelder, T and van Schaik, R H and Balk, A H
             and Van, der Heiden I and van Dam, T and Van der, Werf M and
             Weimar, W and Mathot, R A",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  76,
  number  =  6,
  pages   = "545--556",
  year    =  2004
}

@ARTICLE{Hussein2005-pb,
  title   = "Retrospective population pharmacokinetics of levocetirizine in
             atopic children receiving cetirizine: the {ETAC} study",
  author  = "Hussein, Z and Pitsiu, M and Majid, O and Aarons, L and de
             Longueville, M and Stockis, A",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  59,
  number  =  1,
  pages   = "28--37",
  year    =  2005
}

@ARTICLE{Jolling2004-nt,
  title   = "Population pharmacokinetic analysis of pegylated human
             erythropoietin in rats",
  author  = "Jolling, K and Ruixo, J J and Hemeryck, A and Piotrovskij, V and
             Greway, T",
  journal = "J. Pharm. Sci.",
  volume  =  93,
  number  =  12,
  pages   = "3027--3038",
  year    =  2004
}

@ARTICLE{Jullien2005-zk,
  title   = "Weight related differences in the pharmacokinetics of abacavir in
             {HIV-infected} patients",
  author  = "Jullien, V and Treluyer, J M and Chappuy, H and Dimet, J and Rey,
             E and Dupin, N and Salmon, D and Pons, G and Urien, S",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  59,
  number  =  2,
  pages   = "183--188",
  year    =  2005
}

@ARTICLE{Kappelhoff2005-ek,
  title   = "Development and validation of a population pharmacokinetic model
             for ritonavir used as a booster or as an antiviral agent in
             {HIV-1-infected} patients",
  author  = "Kappelhoff, B S and Huitema, A D and Crommentuyn, K M and Mulder,
             J W and Meenhorst, P L and Van Gorp, E C and Mairuhu, A T and
             Beijnen, J H",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  59,
  number  =  2,
  pages   = "174--182",
  year    =  2005
}

@ARTICLE{Krishna2004-ya,
  title   = "The utility of mixed-effects covariate analysis in rapid selection
             of doses in pediatric subjects: a case study with fexofenadine
             hydrochloride",
  author  = "Krishna, R and Krishnaswami, S and Kittner, B and Sankoh, A J and
             Jensen, B K",
  journal = "Biopharm. Drug Dispos.",
  volume  =  25,
  number  =  9,
  pages   = "373--387",
  year    =  2004
}

@ARTICLE{Lukas2004-vc,
  title   = "Pharmacokinetics of teicoplanin in an {ICU} population of children
             and infants",
  author  = "Lukas, J C and Karikas, G and Gazouli, M and Kalabalikis, P and
             Hatzis, T and Macheras, P",
  journal = "Pharm. Res.",
  volume  =  21,
  number  =  11,
  pages   = "2064--2071",
  year    =  2004
}

@ARTICLE{Sarashina2005-la,
  title   = "Population pharmacokinetics of epinastine, a histamine {H1}
             receptor antagonist, in adults and children",
  author  = "Sarashina, A and Tatami, S and Yamamura, N and Tsuda, Y and
             Igarashi, T",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  59,
  number  =  1,
  pages   = "43--53",
  year    =  2005
}

@ARTICLE{Smith2005-va,
  title   = "Population pharmacokinetics of delavirdine and N-delavirdine in
             {HIV-infected} individuals",
  author  = "Smith, P F and Dicenzo, R and Forrest, A and Shelton, M and
             Friedland, G and Para, M and Pollard, R and Fischl, M and
             DiFrancesco, R and Morse, G D",
  journal = "Clin. Pharmacokinet.",
  volume  =  44,
  number  =  1,
  pages   = "99--109",
  year    =  2005
}

@ARTICLE{Swart2005-il,
  title   = "Population pharmacokinetics of lorazepam and midazolam and their
             metabolites in intensive care patients on continuous venovenous
             hemofiltration",
  author  = "Swart, E L and de Jongh, J and Zuideveld, K P and Danhof, M and
             Thijs, L G and Strack van Schijndel, R J",
  journal = "Am. J. Kidney Dis.",
  volume  =  45,
  number  =  2,
  pages   = "360--371",
  year    =  2005
}

@ARTICLE{Tunblad2005-tx,
  title   = "Influence of probenecid on the delivery of morphine-6-glucuronide
             to the brain",
  author  = "Tunblad, K and Hammarlund-Udenaes, M and Jonsson, E N",
  journal = "Eur. J. Pharm. Sci.",
  volume  =  24,
  number  =  1,
  pages   = "49--57",
  year    =  2005
}

@ARTICLE{Van_Wart2004-tc,
  title   = "Population pharmacokinetics and pharmacodynamics of garenoxacin in
             patients with community-acquired respiratory tract infections",
  author  = "Van Wart, S and Phillips, L and Ludwig, E A and Russo, R and
             Gajjar, D A and Bello, A and Ambrose, P G and Costanzo, C and
             Grasela, T H and Echols, R and Grasela, D M",
  journal = "Antimicrob. Agents Chemother.",
  volume  =  48,
  number  =  12,
  pages   = "4766--4777",
  year    =  2004
}

@ARTICLE{Zandvliet2005-ut,
  title   = "Population pharmacokinetics of caffeine and its metabolites
             theobromine, paraxanthine and theophylline after inhalation in
             combination with diacetylmorphine",
  author  = "Zandvliet, A S and Huitema, A D and de Jonge, M E and den Hoed, R
             and Sparidans, R W and Hendriks, V M and Van den, Brink W and van
             Ree, J M and Beijnen, J H",
  journal = "Basic Clin. Pharmacol. Toxicol.",
  volume  =  96,
  number  =  1,
  pages   = "71--79",
  year    =  2005
}

@ARTICLE{Zhou2004-dd,
  title   = "Unaltered etanercept pharmacokinetics with concurrent methotrexate
             in patients with rheumatoid arthritis",
  author  = "Zhou, H and Mayer, P R and Wajdula, J and Fatenejad, S",
  journal = "J. Clin. Pharmacol.",
  volume  =  44,
  number  =  11,
  pages   = "1235--1243",
  year    =  2004
}

@ARTICLE{Wu2005-cu,
  title   = "Predicting drug disposition via application of {BCS}:
             transport/absorption/ elimination interplay and development of a
             biopharmaceutics drug disposition classification system",
  author  = "Wu, C Y and Benet, L Z",
  journal = "Pharm. Res.",
  volume  =  22,
  number  =  1,
  pages   = "11--23",
  year    =  2005
}

@ARTICLE{Martinez2002-ca,
  title   = "A mechanistic approach to understanding the factors affecting drug
             absorption: a review of fundamentals",
  author  = "Martinez, M N and Amidon, G L",
  journal = "J. Clin. Pharmacol.",
  volume  =  42,
  number  =  6,
  pages   = "620--643",
  year    =  2002
}

@ARTICLE{Holford1992-bs,
  title   = "Models for describing absorption rate and estimating extent of
             bioavailability: Application to Cefetamet Pivoxil",
  author  = "Holford, N H G and Ambros, R J and Stoeckel, K",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  20,
  number  =  5,
  pages   = "421--442",
  year    =  1992
}

@ARTICLE{Grech2003-ku,
  title   = "Acute coronary syndrome: unstable angina and {non-ST} segment
             elevation myocardial infarction",
  author  = "Grech, E D and Ramsdale, D R",
  journal = "BMJ",
  volume  =  326,
  number  =  7401,
  pages   = "1259--1261",
  year    =  2003
}

@ARTICLE{Jneid2003-ok,
  title   = "Aspirin and clopidogrel in acute coronary syndromes: therapeutic
             insights from the {CURE} study",
  author  = "Jneid, H and Bhatt, D L and Corti, R and Badimon, J J and Fuster,
             V and Francis, G S",
  journal = "Arch. Intern. Med.",
  volume  =  163,
  number  =  10,
  pages   = "1145--1153",
  year    =  2003
}

@ARTICLE{Storey2000-vt,
  title   = "The central role of the {P(2T}) receptor in amplification of human
             platelet activation, aggregation, secretion and procoagulant
             activity",
  author  = "Storey, R F and Sanderson, H M and White, A E and May, J A and
             Cameron, K E and Heptinstall, S",
  journal = "Br. J. Haematol.",
  volume  =  110,
  number  =  4,
  pages   = "925--934",
  year    =  2000
}

@BOOK{noauthor_2004-jn,
  title = "{AZD6140} Investigator's Brochure",
  year  =  2004
}

@MISC{Lee_undated-jq,
  title  = "Design of pediatrics population pharmacokinetic studies: Study
            power, precision, and accuracy (Draft 10/16/03)",
  author = "Lee, P and Sun, H and Lesko, L and {Ocpb} and {Cder} and {Fda}"
}

@ARTICLE{Fallon2004-by,
  title   = "A physiologically-based pharmacokinetic model of drug
             detoxification by nanoparticles",
  author  = "Fallon, M S and Varshney, M and Dennis, D M and Chauhan, A",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  31,
  number  =  5,
  pages   = "381--400",
  year    =  2004
}

@ARTICLE{Earp2004-vh,
  title   = "Assessment of drug interactions relevant to pharmacodynamic
             indirect response models",
  author  = "Earp, J and Krzyzanski, W and Chakraborty, A and Zamacona, M K and
             Jusko, W J",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  31,
  number  =  5,
  pages   = "345--380",
  year    =  2004
}

@ARTICLE{Sospedra2005-fz,
  title   = "Immunology of multiple sclerosis",
  author  = "Sospedra, M and Martin, R",
  journal = "Annu. Rev. Immunol.",
  volume  =  23,
  pages   = "683--747",
  year    =  2005
}

@ARTICLE{Meibohm2002-vf,
  title   = "How important are gender differences in pharmacokinetics?",
  author  = "Meibohm, B and Beierle, I and Derendorf, H",
  journal = "Clin. Pharmacokinet.",
  volume  =  41,
  number  =  5,
  pages   = "329--342",
  year    =  2002
}

@ARTICLE{Schwartz2003-pg,
  title   = "The influence of sex on pharmacokinetics",
  author  = "Schwartz, J B",
  journal = "Clin. Pharmacokinet.",
  volume  =  42,
  number  =  2,
  pages   = "107--121",
  year    =  2003
}

@ARTICLE{Cotreau2005-bl,
  title   = "The influence of age and sex on the clearance of cytochrome {P450}
             {3A} substrates",
  author  = "Cotreau, M M and von Moltke, L L and Greenblatt, D J",
  journal = "Clin. Pharmacokinet.",
  volume  =  44,
  number  =  1,
  pages   = "33--60",
  year    =  2005
}

@ARTICLE{Gorski2003-ow,
  title   = "The effect of age, sex, and rifampin administration on intestinal
             and hepatic cytochrome {P450} {3A} activity",
  author  = "Gorski, J C and Vannaprasaht, S and Hamman, M A and Ambrosius, W T
             and Bruce, M A and Haehner-Daniels, B and Hall, S D",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  74,
  number  =  3,
  pages   = "275--287",
  year    =  2003
}

@ARTICLE{Wolbold2003-pb,
  title   = "Sex is a major determinant of {CYP3A4} expression in human liver",
  author  = "Wolbold, R and Klein, K and Burk, O and Nussler, A K and Neuhaus,
             P and Eichelbaum, M and Schwab, M and Zanger, U M",
  journal = "Hepatology",
  volume  =  38,
  number  =  4,
  pages   = "978--988",
  year    =  2003
}

@ARTICLE{Anderson2002-ug,
  title   = "Sex differences in drug metabolism: cytochrome {P-450} and uridine
             diphosphate glucuronosyltransferase",
  author  = "Anderson, G D",
  journal = "J. Gend. Specif. Med.",
  volume  =  5,
  number  =  1,
  pages   = "25--33",
  year    =  2002
}

@ARTICLE{Anthony2002-vz,
  title   = "Biologic and molecular mechanisms for sex differences in
             pharmacokinetics, pharmacodynamics, and pharmacogenetics: Part {I}",
  author  = "Anthony, M and Berg, M J",
  journal = "J. Womens. Health Gend. Based. Med.",
  volume  =  11,
  number  =  7,
  pages   = "601--615",
  year    =  2002
}

@ARTICLE{Giles2003-rp,
  title   = "Adaptive randomized study of idarubicin and cytarabine versus
             troxacitabine and cytarabine versus troxacitabine and idarubicin
             in untreated patients 50 years or older with adverse karyotype
             acute myeloid leukemia",
  author  = "Giles, F J and Kantarjian, H M and Cortes, J E and Garcia-Manero,
             G and Verstovsek, S and Faderl, S and Thomas, D A and Ferrajoli, A
             and O'Brien, S and Wathen, J K and Xiao, L C and Berry, D A and
             Estey, E H",
  journal = "J. Clin. Oncol.",
  volume  =  21,
  number  =  9,
  pages   = "1722--1727",
  year    =  2003
}

@ARTICLE{Hall2005-fd,
  title   = "A group sequential adaptive treatment assignment design for proof
             of concept and dose selection in headache trials",
  author  = "Hall, D B and Meier, U and Diener, H C",
  journal = "Contemp. Clin. Trials",
  volume  =  26,
  number  =  3,
  pages   = "349--364",
  year    =  2005
}

@ARTICLE{Morgan2003-sv,
  title   = "Sample size re-estimation in group-sequential response-adaptive
             clinical trials",
  author  = "Morgan, C C",
  journal = "Stat. Med.",
  volume  =  22,
  number  =  24,
  pages   = "3843--3857",
  year    =  2003
}

@ARTICLE{Karrison2003-by,
  title   = "A group sequential, response-adaptive design for randomized
             clinical trials",
  author  = "Karrison, T G and Huo, D and Chappell, R",
  journal = "Control. Clin. Trials",
  volume  =  24,
  number  =  5,
  pages   = "506--522",
  year    =  2003
}

@ARTICLE{Weir2003-kt,
  title   = "Comparison of stratification and adaptive methods for treatment
             allocation in an acute stroke clinical trial",
  author  = "Weir, C J and Lees, K R",
  journal = "Stat. Med.",
  volume  =  22,
  number  =  5,
  pages   = "705--726",
  year    =  2003
}

@ARTICLE{Berry1995-pv,
  title   = "Adaptive assignment versus balanced randomization in clinical
             trials: a decision analysis",
  author  = "Berry, D A and Eick, S G",
  journal = "Stat. Med.",
  volume  =  14,
  number  =  3,
  pages   = "231--246",
  year    =  1995
}

@ARTICLE{Bischoff2005-ga,
  title   = "Adaptive two-stage test procedures to find the best treatment in
             clinical trials",
  author  = "Bischoff, W and Miller, F",
  journal = "Biometrika",
  volume  =  92,
  number  =  1,
  pages   = "197--212",
  year    =  2005
}

@ARTICLE{ScedilentArk2005-ta,
  title   = "Covariate-adjusted regression",
  author  = "Scedilent{\AA}rk, D and M{\AA}ller, H",
  journal = "Biometrika",
  volume  =  92,
  number  =  1,
  pages   = "75--89",
  year    =  2005
}

@ARTICLE{Kiyoi1999-ct,
  title   = "Prognostic implication of {FLT3} and {N-RAS} gene mutations in
             acute myeloid leukemia",
  author  = "Kiyoi, H and Naoe, T and Nakano, Y and Yokota, S and Minami, S and
             Miyawaki, S and Asou, N and Kuriyama, K and Jinnai, I and
             Shimazaki, C and Akiyama, H and Saito, K and Oh, H and Motoji, T
             and Omoto, E and Saito, H and Ohno, R and Ueda, R",
  journal = "Blood",
  volume  =  93,
  number  =  9,
  pages   = "3074--3080",
  year    =  1999
}

@ARTICLE{Meshinchi2001-nb,
  title   = "Prevalence and prognostic significance of Flt3 internal tandem
             duplication in pediatric acute myeloid leukemia",
  author  = "Meshinchi, S and Woods, W G and Stirewalt, D L and Sweetser, D A
             and Buckley, J D and Tjoa, T K and Bernstein, I D and Radich, J P",
  journal = "Blood",
  volume  =  97,
  number  =  1,
  pages   = "89--94",
  year    =  2001
}

@ARTICLE{Kottaridis2001-da,
  title   = "The presence of a {FLT3} internal tandem duplication in patients
             with acute myeloid leukemia ({AML}) adds important prognostic
             information to cytogenetic risk group and response to the first
             cycle of chemotherapy: analysis of 854 patients from the United
             Kingdom Medical Research Council {AML} 10 and 12 trials",
  author  = "Kottaridis, P D and Gale, R E and Frew, M E and Harrison, G and
             Langabeer, S E and Belton, A A and Walker, H and Wheatley, K and
             Bowen, D T and Burnett, A K and Goldstone, A H and Linch, D C",
  journal = "Blood",
  volume  =  98,
  number  =  6,
  pages   = "1752--1759",
  year    =  2001
}

@ARTICLE{Verstuyft2003-ap,
  title   = "Dipyridamole enhances digoxin bioavailability via P-glycoprotein
             inhibition",
  author  = "Verstuyft, C and Strabach, S and El-Morabet, H and Kerb, R and
             Brinkmann, U and Dubert, L and Jaillon, P and Funck-Brentano, C
             and Trugnan, G and Becquemont, L",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  73,
  number  =  1,
  pages   = "51--60",
  year    =  2003
}

@ARTICLE{Johne2002-lo,
  title   = "Modulation of steady-state kinetics of digoxin by haplotypes of
             the P-glycoprotein {MDR1} gene",
  author  = "Johne, A and Kopke, K and Gerloff, T and Mai, I and Rietbrock, S
             and Meisel, C and Hoffmeyer, S and Kerb, R and Fromm, M F and
             Brinkmann, U and Eichelbaum, M and Brockmoller, J and Cascorbi, I
             and Roots, I",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  72,
  number  =  5,
  pages   = "584--594",
  year    =  2002
}

@ARTICLE{Yanada2005-tu,
  title   = "Prognostic significance of {FLT3} internal tandem duplication and
             tyrosine kinase domain mutations for acute myeloid leukemia: a
             meta-analysis",
  author  = "Yanada, M and Matsuo, K and Suzuki, T and Kiyoi, H and Naoe, T",
  journal = "Leukemia",
  year    =  2005
}

@ARTICLE{Wang2000-zn,
  title   = "Comparative population pharmacokinetic-pharmacodynamic analysis
             for piroxicam-beta-cyclodextrin and piroxicam",
  author  = "Wang, D and Miller, R and Zheng, J and Hu, C",
  journal = "J. Clin. Pharmacol.",
  volume  =  40,
  number  =  11,
  pages   = "1257--1266",
  year    =  2000
}

@ARTICLE{Jamali1999-qc,
  title   = "Pain-mediated altered absorption and metabolism of ibuprofen: an
             explanation for decreased serum enantiomer concentration after
             dental surgery",
  author  = "Jamali, F and Kunz-Dober, C M",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  47,
  number  =  4,
  pages   = "391--396",
  year    =  1999
}

@TECHREPORT{GloboMaxr2002-ep,
  title       = "A population pharmacokinetic analysis of Cidecinr (Daptomycin
                 for injection): Final Report. {NDA} 21-572",
  author      = "GloboMaxr, L L C",
  institution = "Sponsor: Cubist Pharmaceuticals, Inc.",
  year        =  2002
}

@MISC{noauthor_2003-vd,
  title     = "{CubicinT} (Daptomycin for injection) package insert",
  publisher = "Cubist Pharmaceuticals, Inc.",
  year      =  2003
}

@ARTICLE{Dvorchik2004-yi,
  title   = "Population pharmacokinetics of daptomycin",
  author  = "Dvorchik, B and Arbeit, R D and Chung, J and Liu, S and Knebel, W
             and Kastrissios, H",
  journal = "Antimicrob. Agents Chemother.",
  volume  =  48,
  number  =  8,
  pages   = "2799--2807",
  year    =  2004
}

@TECHREPORT{GloboMaxr2003-rt,
  title       = "Final report. Preliminary evaluation of possible Daptomycin
                 exposure - {CPK} relationship for Cidecin r (Daptomycin for
                 injection). {NDA} 21-572",
  author      = "GloboMaxr, L L C",
  institution = "Sponsor: Cubist Pharmaceuticals, Inc.",
  year        =  2003
}

@MISC{noauthor_undated-nq,
  title = "Cubist study report. A randomized, double-blind, placebo controlled
           multiple dose, safety, and pharmacokinetic study of ascending doses
           of daptomycin in healthy volunteers ({DAP-ADT-04-02)}. July 2005"
}

@MISC{noauthor_undated-dt,
  title     = "Study {D51430C05239}. A single-blind, placebo-controlled,
               parallel group, randomised study to investigate the safety,
               tolerability, pharmacokinetics and pharmacodynamic properties of
               multiple ascending doses of {AZD6140} compared to Clopidogrel in
               healthy volunteers",
  publisher = "AstraZeneca Pharmaceuticals LP"
}

@MISC{noauthor_2004-zk,
  title     = "Clinical Pharmacology Study Report {D5130C00019}. An open-label,
               single-dose, randomised, two-treatment, two-way crossover study
               to assess the relative bioavailability of new formulation of
               {AZD6140} immediate release ({IR}) tablets to the formulation of
               {AZD6140} tablets used in previous studies",
  publisher = "AstraZeneca Pharmaceuticals LP",
  year      =  2004
}

@MISC{noauthor_2004-ub,
  title     = "Clinical Study Report {D5130C00008}. A 28-day, randomised,
               double-blind, double-dummy, parallel group, dose finding study
               to investigate the pharmacodynamics and pharmacokinetics of
               {AZD6140} plus acetyl salicylic acid ({ASA}) compared with
               Clopidogrel plus {ASA} in subjects with atherosclerosis",
  publisher = "AstraZeneca Pharmaceuticals LP",
  year      =  2004
}

@MISC{noauthor_undated-qx,
  title     = "Study {D5130C00014}. An open, non-randomized, parallel group
               study to assess the effects of age and gender on the
               pharmacokinetics, pharmacodynamics, safety and tolerability of a
               single oral dose (200 mg) of {AZD6140} in healthy male and
               female volunteers",
  publisher = "AstraZeneca Pharmaceuticals LP"
}

@MISC{noauthor_2005-ss,
  title     = "Clinical Pharmacology Study Report {D5130C05267}. A
               single-blind, randomised, placebo-controlled Phase {I} study to
               assess the safety, tolerability, pharmacokinetics and
               pharmacodynamics of multiple oral doses of {AZD6140} in healthy
               male Japanese and Caucasian volunteers",
  publisher = "AstraZeneca Pharmaceuticals LP",
  year      =  2005
}

@ARTICLE{Greenblatt1998-cf,
  title   = "Comparative kinetics and dynamics of zaleplon, zolpidem, and
             placebo",
  author  = "Greenblatt, D J and Harmatz, J S and von Moltke, L L and
             Ehrenberg, B L and Harrel, L and Corbett, K and Counihan, M and
             Graf, J A and Darwish, M and Mertzanis, P and Martin, P T and
             Cevallos, W H and Shader, R I",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  64,
  number  =  5,
  pages   = "553--561",
  year    =  1998
}

@ARTICLE{Hoddes1973-gs,
  title   = "Quantification of sleepiness: a new approach",
  author  = "Hoddes, E and Zarcone, V and Smythe, H and Phillips, R and Dement,
             W C",
  journal = "Psychophysiology",
  volume  =  10,
  number  =  4,
  pages   = "431--436",
  year    =  1973
}

@MISC{Fisher2004-mi,
  title  = "Population pharmacokinetic meta-analysis of lasofoxifene in
            postmenopausal women",
  author = "Fisher, Jeannine and Riggs, Matthew and Gardner, Mark",
  year   =  2004
}

@ARTICLE{Nishio2005-vr,
  title   = "Interaction between amlodipine and simvastatin in patients with
             hypercholesterolemia and hypertension",
  author  = "Nishio, S and Watanabe, H and Kosuge, K and Uchida, S and Hayashi,
             H and Ohashi, K",
  journal = "Hypertens. Res.",
  volume  =  28,
  number  =  3,
  pages   = "223--227",
  year    =  2005
}

@ARTICLE{Karlsson2005-uq,
  title   = "Pharmacokinetic/pharmacodynamic modelling in oncological drug
             development",
  author  = "Karlsson, M O and Anehall, T and Friberg, L E and Henningsson, A
             and Kloft, C and Sandstrom, M and Xie, R",
  journal = "Basic Clin. Pharmacol. Toxicol.",
  volume  =  96,
  number  =  3,
  pages   = "206--211",
  year    =  2005
}

@ARTICLE{Henningsson2003-os,
  title   = "Population pharmacokinetic modelling of unbound and total plasma
             concentrations of paclitaxel in cancer patients",
  author  = "Henningsson, A and Sparreboom, A and Sandstrom, M and Freijs, A
             and Larsson, R and Bergh, J and Nygren, P and Karlsson, M O",
  journal = "Eur. J. Cancer",
  volume  =  39,
  number  =  8,
  pages   = "1105--1114",
  year    =  2003
}

@ARTICLE{Henningsson2001-rx,
  title   = "Mechanism-based pharmacokinetic model for paclitaxel",
  author  = "Henningsson, A and Karlsson, M O and Vigano, L and Gianni, L and
             Verweij, J and Sparreboom, A",
  journal = "J. Clin. Oncol.",
  volume  =  19,
  number  =  20,
  pages   = "4065--4073",
  year    =  2001
}

@ARTICLE{Boxenbaum1995-fb,
  title   = "Effective half-life in clinical pharmacology",
  author  = "Boxenbaum, H and Battle, M",
  journal = "J. Clin. Pharmacol.",
  volume  =  35,
  number  =  8,
  pages   = "763--766",
  year    =  1995
}

@ARTICLE{Mikkelsen2005-jq,
  title   = "Effects of benzodiazepines receptor agonists on the
             hypothalamic-pituitary-adrenocortical axis",
  author  = "Mikkelsen, J D and Soderman, A and Kiss, A and Mirza, N",
  journal = "Eur. J. Pharmacol.",
  volume  =  519,
  number  =  3,
  pages   = "223--230",
  year    =  2005
}

@ARTICLE{Ette2001-ef,
  title   = "The process of knowledge discovery from large pharmacokinetic data
             sets",
  author  = "Ette, E I and Williams, P and Fadiran, E and Ajayi, F O and
             Onyiah, L C",
  journal = "J. Clin. Pharmacol.",
  volume  =  41,
  number  =  1,
  pages   = "25--34",
  year    =  2001
}

@ARTICLE{Kharasch1999-cc,
  title   = "Intraindividual variability in male hepatic {CYP3A4} activity
             assessed by alfentanil and midazolam clearance",
  author  = "Kharasch, E D and Jubert, C and Senn, T and Bowdle, T A and
             Thummel, K E",
  journal = "J. Clin. Pharmacol.",
  volume  =  39,
  number  =  7,
  pages   = "664--669",
  year    =  1999
}

@ARTICLE{Ribbing2004-wo,
  title   = "Power, selection bias and predictive performance of the Population
             Pharmacokinetic Covariate Model",
  author  = "Ribbing, J and Jonsson, E N",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  31,
  number  =  2,
  pages   = "109--134",
  year    =  2004
}

@ARTICLE{Jonsson2005-zu,
  title   = "Estimation of dosing strategies aiming at maximizing utility or
             responder probability, using oxybutynin as an example drug",
  author  = "Jonsson, S and Karlsson, M O",
  journal = "Eur. J. Pharm. Sci.",
  volume  =  25,
  number  =  1,
  pages   = "123--132",
  year    =  2005
}

@ARTICLE{Gelman2005-pa,
  title   = "Multiple imputation for model checking: completed-data plots with
             missing and latent data",
  author  = "Gelman, A and Van, Mechelen I and Verbeke, G and Heitjan, D F and
             Meulders, M",
  journal = "Biometrics",
  volume  =  61,
  number  =  1,
  pages   = "74--85",
  year    =  2005
}

@ARTICLE{Ogungbenro2005-lv,
  title   = "The use of a modified Fedorov exchange algorithm to optimise
             sampling times for population pharmacokinetic experiments",
  author  = "Ogungbenro, K and Graham, G and Gueorguieva, I and Aarons, L",
  journal = "Comput. Methods Programs Biomed.",
  year    =  2005
}

@ARTICLE{Overgaard2005-by,
  title   = "{Non-Linear} {Mixed-Effects} Models with Stochastic Differential
             Equations: Implementation of an Estimation Algorithm",
  author  = "Overgaard, R V and Jonsson, N and Tornoe, C W and Madsen, H",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  year    =  2005
}

@ARTICLE{Dodds2005-bf,
  title   = "Robust Population Pharmacokinetic Experiment Design",
  author  = "Dodds, M G and Hooker, A C and Vicini, P",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  year    =  2005
}

@ARTICLE{Greenblatt2005-jv,
  title   = "Pharmocokinetics and pharmacodynamics of single-dose triazolam:
             electroencephalography compared with the {Digit-Symbol}
             Substitution Test",
  author  = "Greenblatt, D J and Gan, L and Harmatz, J S and Shader, R I",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  60,
  number  =  3,
  pages   = "244--248",
  year    =  2005
}

@ARTICLE{Harrell1996-qo,
  title   = "Multivariable prognostic models: issues in developing models,
             evaluating assumptions and adequacy, and measuring and reducing
             errors",
  author  = "Harrell, F. E., Jr and Lee, K L and Mark, D B",
  journal = "Stat. Med.",
  volume  =  15,
  number  =  4,
  pages   = "361--387",
  year    =  1996
}

@ARTICLE{Derksen1992-ib,
  title   = "Backward, forward and stepwise auto-mated subset selection
             algorithms: Frequency of obtaining authentic and noise variables",
  author  = "Derksen, S and Keselman, H J",
  journal = "Br. J. Math. Stat. Psychol.",
  volume  =  45,
  pages   = "265--282",
  year    =  1992
}

@ARTICLE{Steyerberg2000-om,
  title   = "Prognostic modelling with logistic regression analysis: a
             comparison of selection and estimation methods in small data sets",
  author  = "Steyerberg, E W and Eijkemans, M J and Harrell, F. E., Jr and
             Habbema, J D",
  journal = "Stat. Med.",
  volume  =  19,
  number  =  8,
  pages   = "1059--1079",
  year    =  2000
}

@ARTICLE{Hogan2004-bo,
  title   = "Handling drop-out in longitudinal studies",
  author  = "Hogan, J W and Roy, J and Korkontzelou, C",
  journal = "Stat. Med.",
  volume  =  23,
  number  =  9,
  pages   = "1455--1497",
  year    =  2004
}

@ARTICLE{Komarova2005-lk,
  title   = "Mathematical model of paracrine interactions between osteoclasts
             and osteoblasts predicts anabolic action of parathyroid hormone on
             bone",
  author  = "Komarova, S V",
  journal = "Endocrinology",
  volume  =  146,
  number  =  8,
  pages   = "3589--3595",
  year    =  2005
}

@ARTICLE{Defranoux2005-hr,
  title   = "In silico modeling and simulation of bone biology: a proposal",
  author  = "Defranoux, N A and Stokes, C L and Young, D L and Kahn, A J",
  journal = "J. Bone Miner. Res.",
  volume  =  20,
  number  =  7,
  pages   = "1079--1084",
  year    =  2005
}

@ARTICLE{Huntjens2005-lq,
  title   = "Pharmacokinetic-pharmacodynamic correlations and biomarkers in the
             development of {COX-2} inhibitors",
  author  = "Huntjens, D R and Danhof, M and la Pasqua, O E",
  journal = "Rheumatology",
  volume  =  44,
  number  =  7,
  pages   = "846--859",
  year    =  2005
}

@ARTICLE{Csajka2005-ye,
  title   = "Mechanistic pharmacokinetic and pharmacodynamic modeling of
             {CHF3381} (2-[(2,3-dihydro-1H-inden-2-yl)amino]acetamide
             monohydrochloride), a novel {N-methyl-D-aspartate} antagonist and
             monoamine oxidase-A inhibitor in healthy subjects",
  author  = "Csajka, C and Imbimbo, B P and Piccinno, A and Dostert, P and
             Verotta, D",
  journal = "J. Pharmacol. Exp. Ther.",
  volume  =  313,
  number  =  2,
  pages   = "647--657",
  year    =  2005
}

@ARTICLE{Earp2004-uo,
  title   = "Assessment of drug interactions relevant to pharmacodynamic
             indirect response models",
  author  = "Earp, J and Krzyzanski, W and Chakraborty, A and Zamacona, M K and
             Jusko, W J",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  31,
  number  =  5,
  pages   = "345--380",
  year    =  2004
}

@ARTICLE{Weiss2004-pl,
  title   = "Inotropic effect of digoxin in humans: mechanistic
             pharmacokinetic/pharmacodynamic model based on slow receptor
             binding",
  author  = "Weiss, M and Kang, W",
  journal = "Pharm. Res.",
  volume  =  21,
  number  =  2,
  pages   = "231--236",
  year    =  2004
}

@ARTICLE{Friberg2003-ki,
  title   = "Mechanistic models for myelosuppression",
  author  = "Friberg, L E and Karlsson, M O",
  journal = "Invest. New Drugs",
  volume  =  21,
  number  =  2,
  pages   = "183--194",
  year    =  2003
}

@ARTICLE{Chabaud2002-ax,
  title   = "Clinical trial simulation using therapeutic effect modeling:
             application to ivabradine efficacy in patients with angina
             pectoris",
  author  = "Chabaud, S and Girard, P and Nony, P and Boissel, J P",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  29,
  number  =  4,
  pages   = "339--363",
  year    =  2002
}

@ARTICLE{Post2005-pn,
  title   = "Disease system analysis: basic disease progression models in
             degenerative disease",
  author  = "Post, T M and Freijer, J I and DeJongh, J and Danhof, M",
  journal = "Pharm. Res.",
  volume  =  22,
  number  =  7,
  pages   = "1038--1049",
  year    =  2005
}

@ARTICLE{Hovind2001-sh,
  title   = "Progression of diabetic nephropathy",
  author  = "Hovind, P and Rossing, P and Tarnow, L and Smidt, U M and Parving,
             H H",
  journal = "Kidney Int.",
  volume  =  59,
  number  =  2,
  pages   = "702--709",
  year    =  2001
}

@ARTICLE{Brinchmann-Hansen1992-jc,
  title   = "Blood glucose concentrations and progression of diabetic
             retinopathy: the seven year results of the Oslo study",
  author  = "Brinchmann-Hansen, O and Dahl-Jorgensen, K and Sandvik, L and
             Hanssen, K F",
  journal = "BMJ",
  volume  =  304,
  number  =  6818,
  pages   = "19--22",
  year    =  1992
}

@ARTICLE{Graham2002-dk,
  title   = "Determination of an optimal dosage regimen using a Bayesian
             decision analysis of efficacy and adverse effect data",
  author  = "Graham, G and Gupta, S and Aarons, L",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  29,
  number  =  1,
  pages   = "67--88",
  year    =  2002
}

@ARTICLE{Colhoun2004-tq,
  title   = "Primary prevention of cardiovascular disease with atorvastatin in
             type 2 diabetes in the Collaborative Atorvastatin Diabetes Study
             ({CARDS)}: multicentre randomised placebo-controlled trial",
  author  = "Colhoun, H M and Betteridge, D J and Durrington, P N and Hitman, G
             A and Neil, H A and Livingstone, S J and Thomason, M J and
             Mackness, M I and Charlton-Menys, V and Fuller, J H",
  journal = "Lancet",
  volume  =  364,
  number  =  9435,
  pages   = "685--696",
  year    =  2004
}

@ARTICLE{Grundy2004-kf,
  title   = "Implications of recent clinical trials for the National
             Cholesterol Education Program Adult Treatment Panel {III}
             guidelines",
  author  = "Grundy, S M and Cleeman, J I and Merz, C N and Brewer, H. B., Jr
             and Clark, L T and Hunninghake, D B and Pasternak, R C and Smith,
             S. C., Jr and Stone, N J",
  journal = "Arterioscler. Thromb. Vasc. Biol.",
  volume  =  24,
  number  =  8,
  pages   = "e149--e161",
  year    =  2004
}

@INCOLLECTION{Mould2001-kk,
  title     = "Defining covariate distribution models for clinical trial
               simulation",
  booktitle = "Simulation for designing clinical trials",
  author    = "Mould, D R and Kimko, H and Duffull, S",
  publisher = "Marcel Dekker",
  year      =  2001,
  address   = "New York"
}

@ARTICLE{Goetghebeur2005-jl,
  title   = "Structural mean models for compliance analysis in randomized
             clinical trials and the impact of errors on measures of exposure",
  author  = "Goetghebeur, E and Stijn, V",
  journal = "Stat. Methods Med. Res.",
  volume  =  14,
  number  =  4,
  pages   = "397--415",
  year    =  2005
}

@ARTICLE{McNabb2003-uz,
  title   = "Patterns of adherence to antiretroviral medications: the value of
             electronic monitoring",
  author  = "McNabb, J J and Nicolau, D P and Stoner, J A and Ross, J",
  journal = "AIDS",
  volume  =  17,
  number  =  12,
  pages   = "1763--1767",
  year    =  2003
}

@ARTICLE{Cramer2005-iq,
  title   = "Compliance and persistence with bisphosphonate dosing regimens
             among women with postmenopausal osteoporosis",
  author  = "Cramer, J A and Amonkar, M M and Hebborn, A and Altman, R",
  journal = "Curr. Med. Res. Opin.",
  volume  =  21,
  number  =  9,
  pages   = "1453--1460",
  year    =  2005
}

@ARTICLE{Hogan2004-ym,
  title   = "Mixtures of varying coefficient models for longitudinal data with
             discrete or continuous nonignorable dropout",
  author  = "Hogan, J W and Lin, X and Herman, B",
  journal = "Biometrics",
  volume  =  60,
  number  =  4,
  pages   = "854--864",
  year    =  2004
}

@ARTICLE{Mallinckrodt2001-ar,
  title   = "Accounting for dropout bias using mixed-effects models",
  author  = "Mallinckrodt, C H and Clark, W S and David, S R",
  journal = "J. Biopharm. Stat.",
  volume  =  11,
  number  = "1-2",
  pages   = "9--21",
  year    =  2001
}

@ARTICLE{LaRosa2003-uk,
  title   = "Reduction of serum {LDL-C} levels: a relationship to clinical
             benefits",
  author  = "LaRosa, J C",
  journal = "Am. J. Cardiovasc. Drugs",
  volume  =  3,
  number  =  4,
  pages   = "271--281",
  year    =  2003
}

@ARTICLE{Li2004-pp,
  title   = "Conditional mixed models adjusting for non-ignorable drop-out with
             administrative censoring in longitudinal studies",
  author  = "Li, J and Schluchter, M D",
  journal = "Stat. Med.",
  volume  =  23,
  number  =  22,
  pages   = "3489--3503",
  year    =  2004
}

@ARTICLE{OMalley2005-dq,
  title   = "Likelihood methods for treatment noncompliance and subsequent
             nonresponse in randomized trials",
  author  = "O'Malley, A J and Normand, S L",
  journal = "Biometrics",
  volume  =  61,
  number  =  2,
  pages   = "325--334",
  year    =  2005
}

@ARTICLE{Kraiczi2005-st,
  title   = "Effect of uncertainty about population parameters on
             pharmacodynamics-based prediction of clinical trial power",
  author  = "Kraiczi, H and Frisen, M",
  journal = "Contemp. Clin. Trials",
  volume  =  26,
  number  =  2,
  pages   = "118--130",
  year    =  2005
}

@ARTICLE{Holford2002-jt,
  title   = "Population disease progress models for the time course of {HAMD}
             score in depressed patients receiving placebo in anti-depressant
             clinical trials",
  author  = "Holford, N and Li, J and Benincosa, L and Birath, M",
  journal = "PAGE. Abstracts of the Annual Meeting of the Population Approach
             Group in Europe",
  volume  = "PAGE 11",
  number  = "Abstr 311",
  year    =  2002
}

@ARTICLE{Post2005-kc,
  title   = "Treatment efficacy of combination-therapy based on a mechanistic
             characterisation of disease processes in type 2 diabetes mellitus
             over a two-year period",
  author  = "Post, T M and de Winter, W and DeJongh, J and Moules, I and
             Urquhart, R and Eckland, D and Danhof, M",
  journal = "PAGE. Abstracts of the Annual Meeting of the Population Approach
             Group in Europe",
  volume  = "PAGE 14",
  number  = "Abstr 757",
  year    =  2005
}

@INCOLLECTION{Law2000-qg,
  title     = "Selecting input probability distributions",
  booktitle = "Simulation Modeling and Analysis",
  author    = "Law, A M and Kelton, W D",
  publisher = "McGraw-Hill",
  volume    = "3rd ed",
  pages     = "292--401",
  year      =  2000
}

@ARTICLE{Farrar1989-vl,
  title   = "Evaluation of uncertainty in input parameters to pharmacokinetic
             models and the resulting uncertainty in output",
  author  = "Farrar, D and Allen, B and Crump, K and Shipp, A",
  journal = "Toxicol. Lett.",
  volume  =  49,
  number  = "2-3",
  pages   = "371--385",
  year    =  1989
}

@ARTICLE{Cheng2001-ve,
  title   = "The power issue: determination of {KB} or Ki from {IC50}. A closer
             look at the {Cheng-Prusoff} equation, the Schild plot and related
             power equations",
  author  = "Cheng, H C",
  journal = "J. Pharmacol. Toxicol. Methods",
  volume  =  46,
  number  =  2,
  pages   = "61--71",
  year    =  2001
}

@ARTICLE{Munson1988-ag,
  title   = "An exact correction to the ``{Cheng-Prusoff}'' correction",
  author  = "Munson, P J and Rodbard, D",
  journal = "J. Recept. Res.",
  volume  =  8,
  number  = "1-4",
  pages   = "533--546",
  year    =  1988
}

@ARTICLE{Cheng1973-rp,
  title   = "Relationship between the inhibition constant (K1) and the
             concentration of inhibitor which causes 50 per cent inhibition
             (I50) of an enzymatic reaction",
  author  = "Cheng, Y and Prusoff, W H",
  journal = "Biochem. Pharmacol.",
  volume  =  22,
  number  =  23,
  pages   = "3099--3108",
  year    =  1973
}

@ARTICLE{Cheng2004-ut,
  title   = "The influence of cooperativity on the determination of
             dissociation constants: examination of the {Cheng-Prusoff}
             equation, the Scatchard analysis, the Schild analysis and related
             power equations",
  author  = "Cheng, H C",
  journal = "Pharmacol. Res.",
  volume  =  50,
  number  =  1,
  pages   = "21--40",
  year    =  2004
}

@ARTICLE{Lazareno1993-tj,
  title   = "Estimation of competitive antagonist affinity from functional
             inhibition curves using the Gaddum, Schild and {Cheng-Prusoff}
             equations",
  author  = "Lazareno, S and Birdsall, N J",
  journal = "Br. J. Pharmacol.",
  volume  =  109,
  number  =  4,
  pages   = "1110--1119",
  year    =  1993
}

@ARTICLE{Lazareno1993-mz,
  title   = "Estimation of antagonist Kb from inhibition curves in functional
             experiments: alternatives to the {Cheng-Prusoff} equation",
  author  = "Lazareno, S and Birdsall, N J",
  journal = "Trends Pharmacol. Sci.",
  volume  =  14,
  number  =  6,
  pages   = "237--239",
  year    =  1993
}

@ARTICLE{Craig1993-ns,
  title   = "The {Cheng-Prusoff} relationship: something lost in the
             translation",
  author  = "Craig, D A",
  journal = "Trends Pharmacol. Sci.",
  volume  =  14,
  number  =  3,
  pages   = "89--91",
  year    =  1993
}

@ARTICLE{Cheng2005-jm,
  title   = "Bayesian adaptive designs for clinical trials",
  author  = "Cheng, Yi and Shen, Yu",
  journal = "Biometrika",
  volume  =  92,
  number  =  3,
  pages   = "633--646",
  year    =  2005
}

@ARTICLE{Bretz2005-lr,
  title   = "Combining multiple comparisons and modeling techniques in
             dose-response studies",
  author  = "Bretz, F and Pinheiro, J C and Branson, M",
  journal = "Biometrics",
  volume  =  61,
  number  =  3,
  pages   = "738--748",
  year    =  2005
}

@ARTICLE{OHara_Hines2005-af,
  title   = "An appraisal of methods for the analysis of longitudinal
             categorical data with {MAR} drop-outs",
  author  = "O'Hara Hines, R J and Hines, W G",
  journal = "Stat. Med.",
  volume  =  24,
  number  =  23,
  pages   = "3549--3563",
  year    =  2005
}

@ARTICLE{Kristensen2005-ly,
  title   = "Using Stochastic Differential Equations for {PK/PD} Model
             Development",
  author  = "Kristensen, N R and Madsen, H and Ingwersen, S H",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  year    =  2005
}

@ARTICLE{Kowalski2001-mb,
  title   = "Design evaluation for a population pharmacokinetic study using
             clinical trial simulations: a case study",
  author  = "Kowalski, K G and Hutmacher, M M",
  journal = "Stat. Med.",
  volume  =  20,
  number  =  1,
  pages   = "75--91",
  year    =  2001
}

@ARTICLE{Nakade2004-jd,
  title   = "Statistical evaluation of clinical trial design for a population
             pharmacokinetic study--a case study",
  author  = "Nakade, S and Nishibori, A and Okamoto, H and Higuchi, S",
  journal = "Drug Metab. Pharmacokinet.",
  volume  =  19,
  number  =  5,
  pages   = "381--389",
  year    =  2004
}

@ARTICLE{Merlotti1989-am,
  title   = "The dose effects of zolpidem on the sleep of healthy normals",
  author  = "Merlotti, L and Roehrs, T and Koshorek, G and Zorick, F and
             Lamphere, J and Roth, T",
  journal = "J. Clin. Psychopharmacol.",
  volume  =  9,
  number  =  1,
  pages   = "9--14",
  year    =  1989
}

@ARTICLE{Scharf1991-rn,
  title   = "Dose response effects of zolpidem in normal geriatric subjects",
  author  = "Scharf, M B and Mayleben, D W and Kaffeman, M and Krall, R and
             Ochs, R",
  journal = "J. Clin. Psychiatry",
  volume  =  52,
  number  =  2,
  pages   = "77--83",
  year    =  1991
}

@MISC{Miller2005-zp,
  title  = "Exposure-response analysis using time to event data: An example
            using sleep onset",
  author = "Miller, R and Ouellet, D and Burger, P and Corrigan, B W",
  volume = "PAGE 14",
  pages  = "[www.page--meeting.org/?abstract=714]",
  year   =  2005
}

@ARTICLE{Struys2005-tc,
  title   = "{AQUAVAN(R}) Injection, a Water-soluble Prodrug of Propofol, as a
             Bolus Injection: A Phase {I} Dose-escalation Comparison with
             {DIPRIVAN(R}) (Part 2): Pharmacodynamics and Safety",
  author  = "Struys, M M and Vanluchene, A L and Gibiansky, E and Gibiansky, L
             and Vornov, J and Mortier, E P and Van, Bortel L",
  journal = "Anesthesiology",
  volume  =  103,
  number  =  4,
  pages   = "730--743",
  year    =  2005
}

@ARTICLE{Gibiansky2005-wi,
  title   = "{AQUAVAN(R}) Injection, a Water-soluble Prodrug of Propofol, as a
             Bolus Injection: A Phase {I} Dose-escalation Comparison with
             {DIPRIVAN(R}) (Part 1): Pharmacokinetics",
  author  = "Gibiansky, E and Struys, M M and Gibiansky, L and Vanluchene, A L
             and Vornov, J and Mortier, E P and Burak, E and Van, Bortel L",
  journal = "Anesthesiology",
  volume  =  103,
  number  =  4,
  pages   = "718--729",
  year    =  2005
}

@ARTICLE{Stanski2005-xy,
  title   = "Getting the Dose Right: Report From the Tenth European Federation
             of Pharmaceutical Sciences ({EUFEPS}) Conference on Optimizing
             Drug Development",
  author  = "Stanski, D R and Rowland, M and Sheiner, L B",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  number  = "Online First",
  year    =  2005
}

@ARTICLE{Miller2005-jl,
  title   = "How Modeling and Simulation Have Enhanced Decision Making in New
             Drug Development",
  author  = "Miller, R and Ewy, W and Corrigan, B W and Ouellet, D and Hermann,
             D and Kowalski, K G and Lockwood, P and Koup, J R and Donevan, S
             and El-Kattan, A and Li, C S and Werth, J L and Feltner, D E and
             Lalonde, R L",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  number  = "Online First",
  year    =  2005
}

% The entry below contains non-ASCII chars that could not be converted
% to a LaTeX equivalent.
@ARTICLE{Chan2005-hx,
  title   = "Importance of Within Subject Variation in Levodopa
             Pharmacokinetics: A 4Year Cohort Study in {Parkinson‚{\"A}{\^o}s}
             Disease",
  author  = "Chan, P and Nutt, J and Holford, N",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  number  = "Online First",
  year    =  2005
}

@ARTICLE{Perez-Ruixo2005-az,
  title   = "Population Cell Life Span Models for Effects of Drugs Following
             Indirect Mechanisms of Action",
  author  = "Perez-Ruixo, J and Kimko, H and Chow, A and Piotrovsky, V and
             Krzyzanski, W and Jusko, W",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  number  = "Online First",
  year    =  2005
}

@ARTICLE{Chenel2005-lp,
  title   = "Optimal Blood Sampling Time Windows for Parameter Estimation Using
             a Population Approach: Design of a Phase {II} Clinical Trial",
  author  = "Chenel, M and Ogungbenro, K and Duval, V and Laveille, C and
             Jochemsen, R and Aarons, L",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  number  = "Online First",
  year    =  2005
}

@ARTICLE{Hutmacher2005-aj,
  title   = "Collapsing Mechanistic Models: An Application to Dose Selection
             for Proof of Concept of a Selective Irreversible Antagonist",
  author  = "Hutmacher, M and Mukherjee, D and Kowalski, K and Jordan, D",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  number  = "Online First",
  year    =  2005
}

@ARTICLE{Duffull2005-bs,
  title   = "Some Considerations on the Design of Population Pharmacokinetic
             Studies",
  author  = "Duffull, S and Waterhouse, T and Eccleston, J",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  number  = "Online First",
  year    =  2005
}

@ARTICLE{Kang2005-vd,
  title   = "Sample Size Computations for {PK/PD} Population Models",
  author  = "Kang, D and Schwartz, J and Verotta, D",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  number  = "Online First",
  year    =  2005
}

@ARTICLE{Jonsson2005-tv,
  title   = "A Longitudinal Model for {Non-Monotonic} Clinical Assessment Scale
             Data",
  author  = "Jonsson, F and Marshall, S and Krams, M and Jonsson, E",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  number  = "Online First",
  year    =  2005
}

@ARTICLE{Zingmark2005-tq,
  title   = "Modelling a Spontaneously Reported Side Effect by Use of a Markov
             {Mixed-Effects} Model",
  author  = "Zingmark, P H and Kagedal, M and Karlsson, M O",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  number  = "Online First",
  year    =  2005
}

@ARTICLE{Murphy2005-uu,
  title   = "Mixed Effects versus Fixed Effects Modelling of Binary Data with
             Inter-subject Variability",
  author  = "Murphy, V and Dunne, A",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  number  = "Online First",
  year    =  2005
}

% The entry below contains non-ASCII chars that could not be converted
% to a LaTeX equivalent.
@ARTICLE{Pillai2005-wb,
  title   = "{Non-Linear} Mixed Effects Modeling ‚{\"A}{\`\i} From Methodology
             and Software Development to Driving Implementation in Drug
             Development Science",
  author  = "Pillai, G and Mentre, F and Steimer, J L",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  number  = "Online First",
  year    =  2005
}

@ARTICLE{Zhou2005-kz,
  title   = "A Computer Simulation Model of Diabetes Progression, Quality of
             Life, and Cost",
  author  = "Zhou, H and Isaman, D J and Messinger, S and Brown, M B and Klein,
             R and Brandle, M and Herman, W H",
  journal = "Diabetes Care",
  volume  =  28,
  number  =  12,
  pages   = "2856--2863",
  year    =  2005
}

@ARTICLE{Kowalski1995-ge,
  title   = "A semicompartmental modeling approach for pharmacodynamic data
             assessment",
  author  = "Kowalski, K G and Karim, A",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  23,
  number  =  3,
  pages   = "307--322",
  year    =  1995
}

@ARTICLE{Lemmens2005-ts,
  title   = "Enriched analgesic efficacy studies: An assessment by clinical
             trial simulation",
  author  = "Lemmens, H J and Wada, D R and Munera, C and Eltahtawy, A and
             Stanski, D R",
  journal = "Contemp. Clin. Trials",
  year    =  2005
}

@ARTICLE{Fraser1980-hz,
  title   = "Regulation of the metabolism of vitamin {D}",
  author  = "Fraser, D R",
  journal = "Physiol. Rev.",
  volume  =  60,
  number  =  2,
  pages   = "551--613",
  year    =  1980
}

@ARTICLE{Burgess1999-wv,
  title   = "The ligand for osteoprotegerin ({OPGL}) directly activates mature
             osteoclasts",
  author  = "Burgess, T L and Qian, Y and Kaufman, S and Ring, B D and Van, G
             and Capparelli, C and Kelley, M and Hsu, H and Boyle, W J and
             Dunstan, C R and Hu, S and Lacey, D L",
  journal = "J. Cell Biol.",
  volume  =  145,
  number  =  3,
  pages   = "527--538",
  year    =  1999
}

@ARTICLE{Capparelli2000-wz,
  title   = "Osteoprotegerin prevents and reverses hypercalcemia in a murine
             model of humoral hypercalcemia of malignancy",
  author  = "Capparelli, C and Kostenuik, P J and Morony, S and Starnes, C and
             Weimann, B and Van, G and Scully, S and Qi, M and Lacey, D L and
             Dunstan, C R",
  journal = "Cancer Res.",
  volume  =  60,
  number  =  4,
  pages   = "783--787",
  year    =  2000
}

@ARTICLE{Cummings2002-ym,
  title   = "How drugs decrease fracture risk: lessons from trials",
  author  = "Cummings, S R",
  journal = "J. Musculoskelet. Neuronal Interact.",
  volume  =  2,
  number  =  3,
  pages   = "198--200",
  year    =  2002
}

@ARTICLE{Cummings2005-bg,
  title   = "Effect of 10 years of Alendronate on the risk of non-spine
             fracture. A novel approach to modeling long-term effects of
             treatments",
  author  = "Cummings, S and Shinoff, C and Palermo, L and Sellmeyer, D and
             McCulloch, C and Ensrud, K",
  journal = "ASBMR 27th Annual meeting",
  volume  = "Presentation Number:M365",
  number  = "http://www.abstractsonline.com/viewer/?mkey=\%7B70A6304C\%2DA41B\%2D49FC\%2DA4DF\%2DC147A5E943F0\%7D\%20",
  year    =  2005
}

@ARTICLE{Chapurlat2005-kp,
  title   = "Risk of fracture among women who lose bone density during
             treatment with alendronate. The Fracture Intervention Trial",
  author  = "Chapurlat, R D and Palermo, L and Ramsay, P and Cummings, S R",
  journal = "Osteoporos. Int.",
  volume  =  16,
  number  =  7,
  pages   = "842--848",
  year    =  2005
}

@ARTICLE{Cohen2005-cy,
  title   = "Phase 2 Study of {AMG} 162 in Postmenopausal Women: Subanalyses
             and Supplemental Safety",
  author  = "Cohen, S B and Lewiecki, E M and Liu, Y and Zack, D J and
             Fitzpatrick, L A",
  journal = "ASBMR 27th Annual meeting",
  volume  = "Presentation Number:SU455",
  number  = "http://www.abstractsonline.com/viewer/?mkey=\%7B70A6304C\%2DA41B\%2D49FC\%2DA4DF\%2DC147A5E943F0\%7D\%20",
  year    =  2005
}

@ARTICLE{Garnero1994-pt,
  title   = "Comparison of new biochemical markers of bone turnover in late
             postmenopausal osteoporotic women in response to alendronate
             treatment",
  author  = "Garnero, P and Shih, W J and Gineyts, E and Karpf, D B and Delmas,
             P D",
  journal = "J. Clin. Endocrinol. Metab.",
  volume  =  79,
  number  =  6,
  pages   = "1693--1700",
  year    =  1994
}

@ARTICLE{Keen2003-cs,
  title   = "Burden of osteoporosis and fractures",
  author  = "Keen, R W",
  journal = "Curr. Osteoporos. Rep.",
  volume  =  1,
  number  =  2,
  pages   = "66--70",
  year    =  2003
}

@ARTICLE{Khosla2001-if,
  title   = "Minireview: the {OPG/RANKL/RANK} system",
  author  = "Khosla, S",
  journal = "Endocrinology",
  volume  =  142,
  number  =  12,
  pages   = "5050--5055",
  year    =  2001
}

@ARTICLE{Kong1999-py,
  title   = "{OPGL} is a key regulator of osteoclastogenesis, lymphocyte
             development and lymph-node organogenesis",
  author  = "Kong, Y Y and Yoshida, H and Sarosi, I and Tan, H L and Timms, E
             and Capparelli, C and Morony, S and Oliveira-dos-Santos, A J and
             Van, G and Itie, A and Khoo, W and Wakeham, A and Dunstan, C R and
             Lacey, D L and Mak, T W and Boyle, W J and Penninger, J M",
  journal = "Nature",
  volume  =  397,
  number  =  6717,
  pages   = "315--323",
  year    =  1999
}

@ARTICLE{Kostenuik2001-rm,
  title   = "Osteoprotegerin: a physiological and pharmacological inhibitor of
             bone resorption",
  author  = "Kostenuik, P J and Shalhoub, V",
  journal = "Curr. Pharm. Des.",
  volume  =  7,
  number  =  8,
  pages   = "613--635",
  year    =  2001
}

@ARTICLE{Kostenuik2005-br,
  title   = "Osteoprotegerin and {RANKL} regulate bone resorption, density,
             geometry and strength",
  author  = "Kostenuik, P J",
  journal = "Curr. Opin. Pharmacol.",
  volume  =  5,
  number  =  6,
  pages   = "618--625",
  year    =  2005
}

@ARTICLE{Li2000-py,
  title   = "{RANK} is the intrinsic hematopoietic cell surface receptor that
             controls osteoclastogenesis and regulation of bone mass and
             calcium metabolism",
  author  = "Li, J and Sarosi, I and Yan, X Q and Morony, S and Capparelli, C
             and Tan, H L and McCabe, S and Elliott, R and Scully, S and Van, G
             and Kaufman, S and Juan, S C and Sun, Y and Tarpley, J and Martin,
             L and Christensen, K and McCabe, J and Kostenuik, P and Hsu, H and
             Fletcher, F and Dunstan, C R and Lacey, D L and Boyle, W J",
  journal = "Proc. Natl. Acad. Sci. U. S. A.",
  volume  =  97,
  number  =  4,
  pages   = "1566--1571",
  year    =  2000
}

@ARTICLE{Martin1994-lr,
  title   = "Mathematical model for the mineralization of bone",
  author  = "Martin, B",
  journal = "J. Orthop. Res.",
  volume  =  12,
  number  =  3,
  pages   = "375--383",
  year    =  1994
}

@INCOLLECTION{Parfitt1993-zd,
  title     = "Calcium homeostasis",
  booktitle = "Physiology and pharmacology of bone",
  author    = "Parfitt, A M and Mundy, G R and Martin, T J",
  publisher = "Springer-Verlag",
  pages     = "1--66",
  series    = "Handbook of Experimental Pharmacology series",
  year      =  1993,
  address   = "Berlin"
}

@ARTICLE{Poole2005-yd,
  title   = "Sclerostin is a delayed secreted product of osteocytes that
             inhibits bone formation",
  author  = "Poole, K E and van Bezooijen, R L and Loveridge, N and Hamersma, H
             and Papapoulos, S E and Lowik, C W and Reeve, J",
  journal = "FASEB J.",
  volume  =  19,
  number  =  13,
  pages   = "1842--1844",
  year    =  2005
}

@ARTICLE{Sheikh1990-sx,
  title   = "In vivo intestinal absorption of calcium in humans",
  author  = "Sheikh, M S and Schiller, L R and Fordtran, J S",
  journal = "Miner. Electrolyte Metab.",
  volume  =  16,
  number  = "2-3",
  pages   = "130--146",
  year    =  1990
}

@ARTICLE{Weiss1994-yj,
  title   = "A non-Markovian model for calcium kinetics in the body",
  author  = "Weiss, G H and Goans, R E and Gitterman, M and Abrams, S A and
             Vieira, N E and Yergey, A L",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  22,
  number  =  5,
  pages   = "367--379",
  year    =  1994
}

@ARTICLE{Kurbel2003-pt,
  title   = "A calcium homeostasis model: orchestration of fast acting {PTH}
             and calcitonin with slow calcitriol",
  author  = "Kurbel, S and Radic, R and Kotromanovic, Z and Puseljic, Z and
             Kratofil, B",
  journal = "Med. Hypotheses",
  volume  =  61,
  number  =  3,
  pages   = "346--350",
  year    =  2003
}

@ARTICLE{Avogaro1996-vs,
  title   = "The hot but not the cold minimal model allows precise assessment
             of insulin sensitivity in {NIDDM} subjects",
  author  = "Avogaro, A and Vicini, P and Valerio, A and Caumo, A and Cobelli,
             C",
  journal = "Am. J. Physiol.",
  volume  =  270,
  number  = "3 Pt 1",
  pages   = "E532--E540",
  year    =  1996
}

@ARTICLE{Mould2005-mx,
  title   = "Population pharmacokinetics: A memorial tribute to Lewis Sheiner",
  author  = "Mould, D R and Bonate, P L",
  journal = "AAPS J.",
  volume  =  07,
  number  =  02,
  pages   = "E361--E362",
  year    =  2005
}

@ARTICLE{Bonate2005-ph,
  title   = "Recommended reading in population pharmacokinetic pharmacodynamics",
  author  = "Bonate, P L",
  journal = "AAPS J.",
  volume  =  7,
  number  =  2,
  pages   = "E363--E373",
  year    =  2005
}

@ARTICLE{Nedelman2005-db,
  title   = "On some ``disadvantages'' of the population approach",
  author  = "Nedelman, J R",
  journal = "AAPS J.",
  volume  =  7,
  number  =  2,
  pages   = "E374--E382",
  year    =  2005
}

@ARTICLE{Olofsen2005-kx,
  title   = "Population pharmacokinetics/pharmacodynamics of anesthetics",
  author  = "Olofsen, E and Dahan, A",
  journal = "AAPS J.",
  volume  =  7,
  number  =  2,
  pages   = "E383--E389",
  year    =  2005
}

@ARTICLE{Kenna2005-rp,
  title   = "Modeling and simulation of adherence: approaches and applications
             in therapeutics",
  author  = "Kenna, L A and Labbe, L and Barrett, J S and Pfister, M",
  journal = "AAPS J.",
  volume  =  7,
  number  =  2,
  pages   = "E390--E407",
  year    =  2005
}

@ARTICLE{Roy2005-ii,
  title   = "A pragmatic approach to the design of population pharmacokinetic
             studies",
  author  = "Roy, A and Ette, E I",
  journal = "AAPS J.",
  volume  =  7,
  number  =  2,
  pages   = "E408--E420",
  year    =  2005
}

@ARTICLE{Wade2005-dy,
  title   = "A guide for reporting the results of population pharmacokinetic
             analyses: a Swedish perspective",
  author  = "Wade, J R and Edholm, M and Salmonson, T",
  journal = "AAPS J.",
  volume  =  7,
  number  =  2,
  pages   = "E",
  year    =  2005
}

@ARTICLE{Girgis2005-bi,
  title   = "Pharmacodynamic parameter estimation: population size versus
             number of samples",
  author  = "Girgis, S and Pai, S M and Girgis, I G and Batra, V K",
  journal = "AAPS J.",
  volume  =  7,
  number  =  2,
  pages   = "E",
  year    =  2005
}

@ARTICLE{Lee2005-me,
  title   = "Evidence of effectiveness: how much can we extrapolate from
             existing studies?",
  author  = "Lee, H and Yim, D S and Zhou, H and Peck, C C",
  journal = "AAPS J.",
  volume  =  7,
  number  =  2,
  pages   = "E467--E474",
  year    =  2005
}

@ARTICLE{Meibohm2005-qv,
  title   = "Population pharmacokinetic studies in pediatrics: issues in design
             and analysis",
  author  = "Meibohm, B and Laer, S and Panetta, J C and Barrett, J S",
  journal = "AAPS J.",
  volume  =  7,
  number  =  2,
  pages   = "E475--E487",
  year    =  2005
}

@ARTICLE{Grasela2005-rc,
  title   = "Challenges in the transition to model-based development",
  author  = "Grasela, T H and Fiedler-Kelly, J and Walawander, C A and Owen, J
             S and Cirincione, B B and Reitz, K E and Ludwig, E A and
             Passarell, J A and Dement, C W",
  journal = "AAPS J.",
  volume  =  7,
  number  =  2,
  pages   = "E488--E495",
  year    =  2005
}

@ARTICLE{Bhattaram2005-mf,
  title   = "Impact of pharmacometrics on drug approval and labeling decisions:
             a survey of 42 new drug applications",
  author  = "Bhattaram, V A and Booth, B P and Ramchandani, R P and Beasley, B
             N and Wang, Y and Tandon, V and Duan, J Z and Baweja, R K and
             Marroum, P J and Uppoor, R S and Rahman, N A and Sahajwalla, C G
             and Powell, J R and Mehta, M U and Gobburu, J V",
  journal = "AAPS J.",
  volume  =  7,

repository: yonicd/paperpile

repo_name: yonicd/paperpile