text:
ancer Chemother. Pharmacol.",
  volume  =  35,
  number  =  5,
  pages   = "417--422",
  year    =  1995
}

@ARTICLE{Vielhaber1994-aa,
  title   = "{NM-Win}: a personal computer-based Microsoft Windows front-end to
             {NONMEM} {IV}",
  author  = "Vielhaber, J P and Barrett, J S",
  journal = "Pharm. Res.",
  volume  =  11,
  number  =  5,
  pages   = "709--714",
  year    =  1994
}

@ARTICLE{De_Gaetano1994-po,
  title   = "{PC-based} differential model fitting as a support for clinical
             research",
  author  = "De Gaetano, A and Castagneto, M and Mingrone, G and Coleman, W P
             and Sganga, G and Tataranni, P A and Gangeri, G and Greco, A V",
  journal = "Int. J. Clin. Monit. Comput.",
  volume  =  11,
  number  =  1,
  pages   = "35--41",
  year    =  1994
}

@ARTICLE{Vielhaber1994-vc,
  title   = "Updating {NONMEM} {IV} installation and execution on the {VAX}
             9000: {DCL} procedure for single-step execution",
  author  = "Vielhaber, J P and Kuhlman, J V and Barrett, J S",
  journal = "Comput. Methods Programs Biomed.",
  volume  =  42,
  number  =  1,
  pages   = "71--72",
  year    =  1994
}

@ARTICLE{Kobayashi1993-mg,
  title   = "Pharmacodynamic-pharmacokinetic relationships and therapeutic drug
             monitoring",
  author  = "Kobayashi, K and Jodrell, D I and Ratain, M J",
  journal = "Cancer Surv.",
  volume  =  17,
  pages   = "51--78",
  year    =  1993
}

@ARTICLE{Verme1992-su,
  title   = "Pharmacokinetics of quinidine in male patients. A population
             analysis",
  author  = "Verme, C N and Ludden, T M and Clementi, W A and Harris, S C",
  journal = "Clin. Pharmacokinet.",
  volume  =  22,
  number  =  6,
  pages   = "468--480",
  year    =  1992
}

@ARTICLE{Uehlinger1992-hv,
  title   = "A pharmacodynamic model of erythropoietin therapy for uremic
             anemia",
  author  = "Uehlinger, D E and Gotch, F A and Sheiner, L B",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  51,
  number  =  1,
  pages   = "76--89",
  year    =  1992
}

@ARTICLE{Thomson1989-nl,
  title   = "Lisinopril population pharmacokinetics in elderly and renal
             disease patients with hypertension",
  author  = "Thomson, A H and Kelly, J G and Whiting, B",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  27,
  number  =  1,
  pages   = "57--65",
  year    =  1989
}

@ARTICLE{Thomson1988-ye,
  title   = "Population pharmacokinetics of gentamicin in neonates",
  author  = "Thomson, A H and Way, S and Bryson, S M and McGovern, E M and
             Kelman, A W and Whiting, B",
  journal = "Dev. Pharmacol. Ther.",
  volume  =  11,
  number  =  3,
  pages   = "173--179",
  year    =  1988
}

@ARTICLE{Aarons1991-ef,
  title   = "The kinetics of flurbiprofen in synovial fluid",
  author  = "Aarons, L",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  19,
  number  =  3,
  pages   = "265--269",
  year    =  1991
}

@ARTICLE{Ludden1988-qr,
  title   = "Population pharmacokinetics",
  author  = "Ludden, T M",
  journal = "J. Clin. Pharmacol.",
  volume  =  28,
  number  =  12,
  pages   = "1059--1063",
  year    =  1988
}

@ARTICLE{Yuh1994-bk,
  title   = "Population pharmacokinetic/pharmacodynamic methodology and
             applications: a bibliography",
  author  = "Yuh, L and Beal, S and Davidian, M and Harrison, F and Hester, A
             and Kowalski, K and Vonesh, E and Wolfinger, R",
  journal = "Biometrics",
  volume  =  50,
  number  =  2,
  pages   = "566--575",
  year    =  1994
}

@ARTICLE{Samara1997-ci,
  title   = "Role of population pharmacokinetics in drug development. A
             pharmaceutical industry perspective",
  author  = "Samara, E and Granneman, R",
  journal = "Clin. Pharmacokinet.",
  volume  =  32,
  number  =  4,
  pages   = "294--312",
  year    =  1997
}

@ARTICLE{Sheiner1980-ca,
  title   = "Evaluation of methods for estimating population pharmacokinetic
             parameters. I. {Michaelis-Menten} model: routine clinical
             pharmacokinetic data",
  author  = "Sheiner, L B and Beal, S L",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  8,
  number  =  6,
  pages   = "553--571",
  year    =  1980
}

@ARTICLE{Grasela1987-tu,
  title   = "An evaluation of population pharmacokinetics in therapeutic
             trials. Part {II}. Detection of a drug-drug interaction",
  author  = "Grasela, T. H., Jr and Antal, E J and Ereshefsky, L and Wells, B G
             and Evans, R L and Smith, R B",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  42,
  number  =  4,
  pages   = "433--441",
  year    =  1987
}

@ARTICLE{Antal1989-ht,
  title   = "An evaluation of population pharmacokinetics in therapeutic
             trials. Part {III}. Prospective data collection versus
             retrospective data assembly",
  author  = "Antal, E J and Grasela, T. H., Jr and Smith, R B",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  46,
  number  =  5,
  pages   = "552--559",
  year    =  1989
}

@ARTICLE{Al_Banna1990-km,
  title   = "Experimental design and efficient parameter estimation in
             population pharmacokinetics",
  author  = "al Banna, M K and Kelman, A W and Whiting, B",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  18,
  number  =  4,
  pages   = "347--360",
  year    =  1990
}

@ARTICLE{Hashimoto1995-qw,
  title   = "Simulation for population analysis of {Michaelis-Menten}
             elimination kinetics",
  author  = "Hashimoto, Y and Koue, T and Otsuki, Y and Yasuhara, M and Hori, R
             and Inui, K",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  23,
  number  =  2,
  pages   = "205--216",
  year    =  1995
}

@ARTICLE{Jonsson1996-zj,
  title   = "Comparison of some practical sampling strategies for population
             pharmacokinetic studies",
  author  = "Jonsson, E N and Wade, J R and Karlsson, M O",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  24,
  number  =  2,
  pages   = "245--263",
  year    =  1996
}

@ARTICLE{Jonsson1997-xk,
  title   = "Discrimination between rival dosing histories",
  author  = "Jonsson, E N and Wade, J R and Almqvist, G and Karlsson, M O",
  journal = "Pharm. Res.",
  volume  =  14,
  number  =  8,
  pages   = "984--991",
  year    =  1997
}

@ARTICLE{Karlsson1998-be,
  title   = "Assumption testing in population pharmacokinetic models:
             illustrated with an analysis of moxonidine data from congestive
             heart failure patients",
  author  = "Karlsson, M O and Jonsson, E N and Wiltse, C G and Wade, J R",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  26,
  number  =  2,
  pages   = "207--246",
  year    =  1998
}

@ARTICLE{Sadray1999-rq,
  title   = "Likelihood-based diagnostics for influential individuals in
             non-linear mixed effects model selection",
  author  = "Sadray, S and Jonsson, E N and Karlsson, M O",
  journal = "Pharm. Res.",
  volume  =  16,
  number  =  8,
  pages   = "1260--1265",
  year    =  1999
}

@ARTICLE{Gardmark1999-hr,
  title   = "Interchangeability and predictive performance of empirical
             tolerance models",
  author  = "Gardmark, M and Brynne, L and Hammarlund-Udenaes, M and Karlsson,
             M O",
  journal = "Clin. Pharmacokinet.",
  volume  =  36,
  number  =  2,
  pages   = "145--167",
  year    =  1999
}

@ARTICLE{Laporte-Simitsidis2000-yp,
  title   = "Inter-study variability in population pharmacokinetic
             meta-analysis: when and how to estimate it?",
  author  = "Laporte-Simitsidis, S and Girard, P and Mismetti, P and Chabaud, S
             and Decousus, H and Boissel, J P",
  journal = "J. Pharm. Sci.",
  volume  =  89,
  number  =  2,
  pages   = "155--167",
  year    =  2000
}

@ARTICLE{Beal2001-df,
  title   = "Ways to fit a {PK} model with some data below the quantification
             limit",
  author  = "Beal, S L",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  28,
  number  =  5,
  pages   = "481--504",
  year    =  2001
}

@ARTICLE{Mungall1985-kl,
  title   = "Population pharmacokinetics of racemic warfarin in adult patients",
  author  = "Mungall, D R and Ludden, T M and Marshall, J and Hawkins, D W and
             Talbert, R L and Crawford, M H",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  13,
  number  =  3,
  pages   = "213--227",
  year    =  1985
}

@ARTICLE{Ajayi1985-ca,
  title   = "Pharmacodynamics and population pharmacokinetics of enalapril and
             lisinopril",
  author  = "Ajayi, A A and Campbell, B C and Kelman, A W and Howie, C and
             Meredith, P A and Reid, J L",
  journal = "Int. J. Clin. Pharmacol. Res.",
  volume  =  5,
  number  =  6,
  pages   = "419--427",
  year    =  1985
}

@ARTICLE{Miller1987-mq,
  title   = "Population pharmacokinetics of phenytoin in South African black
             patients",
  author  = "Miller, R and Rheeders, M and Klein, C and Suchet, I",
  journal = "S. Afr. Med. J.",
  volume  =  72,
  number  =  3,
  pages   = "188--190",
  year    =  1987
}

@ARTICLE{Maitre1987-iu,
  title   = "Population pharmacokinetics of alfentanil: the average dose-plasma
             concentration relationship and interindividual variability in
             patients",
  author  = "Maitre, P O and Vozeh, S and Heykants, J and Thomson, D A and
             Stanski, D R",
  journal = "Anesthesiology",
  volume  =  66,
  number  =  1,
  pages   = "3--12",
  year    =  1987
}

@ARTICLE{Thomson1987-us,
  title   = "Changes in lignocaine disposition during long-term infusion in
             patients with acute ventricular arrhythmias",
  author  = "Thomson, A H and Kelman, A W and de Vane, P J and Hillis, W S and
             Whiting, B",
  journal = "Ther. Drug Monit.",
  volume  =  9,
  number  =  3,
  pages   = "283--291",
  year    =  1987
}

@ARTICLE{Bach1989-pf,
  title   = "A randomized comparison between midazolam and thiopental for
             elective cesarean section anesthesia: {III}. Placental transfer
             and elimination in neonates",
  author  = "Bach, V and Carl, P and Ravlo, O and Crawford, M E and Jensen, A G
             and Mikkelsen, B O and Crevoisier, C and Heizmann, P and
             Fattinger, K",
  journal = "Anesth. Analg.",
  volume  =  68,
  number  =  3,
  pages   = "238--242",
  year    =  1989
}

@ARTICLE{Moore1989-zz,
  title   = "The population pharmacokinetics of theophylline in neonates and
             young infants",
  author  = "Moore, E S and Faix, R G and Banagale, R C and Grasela, T H",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  17,
  number  =  1,
  pages   = "47--66",
  year    =  1989
}

@ARTICLE{Aarons1989-ad,
  title   = "Population pharmacokinetics of tobramycin",
  author  = "Aarons, L and Vozeh, S and Wenk, M and Weiss, P and Follath, F",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  28,
  number  =  3,
  pages   = "305--314",
  year    =  1989
}

@ARTICLE{Cohen1990-zv,
  title   = "Gentamicin pharmacokinetics in neonates undergoing extracorporal
             membrane oxygenation",
  author  = "Cohen, P and Collart, L and Prober, C G and Fischer, A F and
             Blaschke, T F",
  journal = "Pediatr. Infect. Dis. J.",
  volume  =  9,
  number  =  8,
  pages   = "562--566",
  year    =  1990
}

@ARTICLE{Tanigawara1990-oe,
  title   = "Pharmacokinetics in chimpanzees of recombinant human tissue-type
             plasminogen activator produced in mouse {C127} and Chinese hamster
             ovary cells",
  author  = "Tanigawara, Y and Hori, R and Okumura, K and Tsuji, J and Shimizu,
             N and Noma, S and Suzuki, J and Livingston, D J and Richards, S M
             and Keyes, L D",
  journal = "Chem. Pharm. Bull.",
  volume  =  38,
  number  =  2,
  pages   = "517--522",
  year    =  1990
}

@ARTICLE{Fattinger1991-ul,
  title   = "Population pharmacokinetics of quinidine",
  author  = "Fattinger, K and Vozeh, S and Ha, H R and Borner, M and Follath, F",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  31,
  number  =  3,
  pages   = "279--286",
  year    =  1991
}

@ARTICLE{Fattinger1991-bx,
  title   = "Netilmicin in the neonate: population pharmacokinetic analysis and
             dosing recommendations",
  author  = "Fattinger, K and Vozeh, S and Olafsson, A and Vlcek, J and Wenk, M
             and Follath, F",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  50,
  number  =  1,
  pages   = "55--65",
  year    =  1991
}

@ARTICLE{Wiest1991-ti,
  title   = "Population pharmacokinetics of intravenous indomethacin in
             neonates with symptomatic patent ductus arteriosus",
  author  = "Wiest, D B and Pinson, J B and Gal, P S and Brundage, R C and
             Schall, S and Ransom, J L and Weaver, R L and Purohit, D and
             Brown, Y",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  49,
  number  =  5,
  pages   = "550--557",
  year    =  1991
}

@ARTICLE{Aarons1991-uw,
  title   = "A population analysis of the pharmacokinetics and pharmacodynamics
             of midazolam in the rat",
  author  = "Aarons, L and Mandema, J W and Danhof, M",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  19,
  number  =  5,
  pages   = "485--496",
  year    =  1991
}

@ARTICLE{Schmitt1992-ot,
  title   = "Hemodynamic and humoral effects of the novel calcium antagonist Ro
             40- 5967 in patients with hypertension",
  author  = "Schmitt, R and Kleinbloesem, C H and Belz, G G and Schroeter, V
             and Feifel, U and Pozenel, H and Kirch, W and Halabi, A and
             Woittiez, A J and Welker, H A",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  52,
  number  =  3,
  pages   = "314--323",
  year    =  1992
}

@ARTICLE{Holford1992-it,
  title   = "Models for describing absorption rate and estimating extent of
             bioavailability: application to cefetamet pivoxil",
  author  = "Holford, N H and Ambros, R J and Stoeckel, K",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  20,
  number  =  5,
  pages   = "421--442",
  year    =  1992
}

@ARTICLE{Kleinbloesem1993-fn,
  title   = "Hemodynamics, biochemical effects, and pharmacokinetics of the
             renin inhibitor remikiren in healthy human subjects",
  author  = "Kleinbloesem, C H and Weber, C and Fahrner, E and Dellenbach, M
             and Welker, H and Schroter, V and Belz, G G",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  53,
  number  =  5,
  pages   = "585--592",
  year    =  1993
}

@ARTICLE{Grevel1993-rt,
  title   = "{Michaelis-Menten} kinetics determine cyclosporine steady-state
             concentrations: a population analysis in kidney transplant
             patients",
  author  = "Grevel, J and Post, B K and Kahan, B D",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  53,
  number  =  6,
  pages   = "651--660",
  year    =  1993
}

@ARTICLE{Ganes1993-al,
  title   = "Population pharmacodynamic modeling of drug-induced anemia",
  author  = "Ganes, D and Bansal, S and Johnson, D and Leal, M and Nicolau, G
             and Yacobi, A",
  journal = "J. Pharm. Sci.",
  volume  =  82,
  number  =  5,
  pages   = "546--549",
  year    =  1993
}

@ARTICLE{Grasela1993-df,
  title   = "Predictive performance of population pharmacokinetic parameters of
             tianeptine as applied to plasma concentrations from a
             post-marketing study",
  author  = "Grasela, T H and Fiedler-Kelly, J B and Salvadori, C and Marey, C
             and Jochemsen, R and Loo, H",
  journal = "Eur. J. Clin. Pharmacol.",
  volume  =  45,
  number  =  2,
  pages   = "123--128",
  year    =  1993
}

@ARTICLE{Fisher1994-jx,
  title   = "Propofol in pediatrics. Lessons in pharmacokinetic modeling",
  author  = "Fisher, D M",
  journal = "Anesthesiology",
  volume  =  80,
  number  =  1,
  pages   = "2--5",
  year    =  1994
}

@ARTICLE{Holford1994-rn,
  title   = "The effect of tacrine and lecithin in Alzheimer's disease. A
             population pharmacodynamic analysis of five clinical trials",
  author  = "Holford, N H and Peace, K",
  journal = "Eur. J. Clin. Pharmacol.",
  volume  =  47,
  number  =  1,
  pages   = "17--23",
  year    =  1994
}

@ARTICLE{Liu1995-ri,
  title   = "Pharmacodynamic analysis of analgesic clinical trials using
             empirical methods",
  author  = "Liu, C Y and Sambol, N C",
  journal = "Pharm. Res.",
  volume  =  12,
  number  =  3,
  pages   = "438--445",
  year    =  1995
}

@ARTICLE{Holford1995-oc,
  title   = "Population pharmacodynamics of romazarit",
  author  = "Holford, N H and Williams, P E and Muirhead, G J and Mitchell, A
             and York, A",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  39,
  number  =  3,
  pages   = "313--320",
  year    =  1995
}

@ARTICLE{Bragg1995-re,
  title   = "Opioid pharmacodynamics in neonatal dogs: differences between
             morphine and fentanyl",
  author  = "Bragg, P and Zwass, M S and Lau, M and Fisher, D M",
  journal = "J. Appl. Physiol.",
  volume  =  79,
  number  =  5,
  pages   = "1519--1524",
  year    =  1995
}

@ARTICLE{Troconiz1995-fb,
  title   = "Tenoxicam pharmacokinetics in rats: a population model",
  author  = "Troconiz, I F and Lopez-Bustamante, L G and Fos, D",
  journal = "J. Pharm. Sci.",
  volume  =  84,
  number  =  12,
  pages   = "1482--1487",
  year    =  1995
}

@ARTICLE{Thomson1996-ui,
  title   = "Population pharmacokinetics of caffeine in neonates and young
             infants",
  author  = "Thomson, A H and Kerr, S and Wright, S",
  journal = "Ther. Drug Monit.",
  volume  =  18,
  number  =  3,
  pages   = "245--253",
  year    =  1996
}

@ARTICLE{Korth-Bradley1996-nu,
  title   = "Population pharmacokinetics of intravenous amiodarone in patients
             with refractory ventricular tachycardia/fibrillation",
  author  = "Korth-Bradley, J M and Rose, G M and de Vane, P J and Peters, J
             and Chiang, S T",
  journal = "J. Clin. Pharmacol.",
  volume  =  36,
  number  =  8,
  pages   = "715--719",
  year    =  1996
}

@ARTICLE{Gatti1996-dn,
  title   = "Population pharmacokinetics of dapsone administered biweekly to
             human immunodeficiency virus-infected patients",
  author  = "Gatti, G and Merighi, M and Hossein, J and Travaini, S and
             Casazza, R and Karlsson, M and Cruciani, M and Bassetti, D",
  journal = "Antimicrob. Agents Chemother.",
  volume  =  40,
  number  =  12,
  pages   = "2743--2748",
  year    =  1996
}

@ARTICLE{Zhou1996-oj,
  title   = "Population pharmacokinetics of ganciclovir in newborns with
             congenital cytomegalovirus infections. {NIAID} Collaborative
             Antiviral Study {Group.PG}",
  author  = "Zhou, X J and Gruber, W and Demmler, G and Jacobs, R and Reuman, P
             and Adler, S and Shelton, M and Pass, R and Britt, B and Trang, J
             M and Whitley, R J and Sommadossi, J P",
  journal = "Antimicrob. Agents Chemother.",
  volume  =  40,
  number  =  9,
  year    =  1996
}

@ARTICLE{Hallen1996-vd,
  title   = "Toxicokinetics of lead in lactating and nonlactating mice",
  author  = "Hallen, I P and Jonsson, S and Karlsson, M O and Oskarsson, A",
  journal = "Toxicol. Appl. Pharmacol.",
  volume  =  136,
  number  =  2,
  pages   = "342--347",
  year    =  1996
}

@ARTICLE{Murat1996-ta,
  title   = "Pharmacokinetics of propofol after a single dose in children aged
             1-3 years with minor burns. Comparison of three data analysis
             {approaches.PG}",
  author  = "Murat, I and Billard, V and Vernois, J and Zaouter, M and Marsol,
             P and Souron, R and Farinotti, R",
  journal = "Anesthesiology",
  volume  =  84,
  number  =  3,
  year    =  1996
}

@ARTICLE{Shangraw1996-cs,
  title   = "Pharmacokinetics of dichloroacetate in patients undergoing liver
             transplantation",
  author  = "Shangraw, R E and Fisher, D M",
  journal = "Anesthesiology",
  volume  =  84,
  number  =  4,
  pages   = "851--858",
  year    =  1996
}

@ARTICLE{Hussein1997-pd,
  title   = "Population pharmacokinetics of atovaquone in patients with acute
             malaria caused by Plasmodium falciparum",
  author  = "Hussein, Z and Eaves, J and Hutchinson, D B and Canfield, C J",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  61,
  number  =  5,
  pages   = "518--530",
  year    =  1997
}

@ARTICLE{Racine-Poon1997-tv,
  title   = "Efficacy, pharmacodynamics, and pharmacokinetics of {CGP} 51901,
             an anti-immunoglobulin {E} chimeric monoclonal antibody, in
             patients with seasonal allergic rhinitis",
  author  = "Racine-Poon, A and Botta, L and Chang, T W and Davis, F M and
             Gygax, D and Liou, R S and Rohane, P and Staehelin, T and van
             Steijn, A M and Frank, W",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  62,
  number  =  6,
  pages   = "675--690",
  year    =  1997
}

@ARTICLE{Karlsson1997-vd,
  title   = "A population model for the follicular growth in women treated with
             follicle stimulating hormone",
  author  = "Karlsson, M O and Wade, J R and Loumaye, E and Munafo, A",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  62,
  number  =  6,
  pages   = "665--674",
  year    =  1997
}

@ARTICLE{Tuk1997-aw,
  title   = "Pharmacodynamics of temazepam in primary insomnia: assessment of
             the value of quantitative electroencephalography and saccadic eye
             movements in predicting improvement of sleep",
  author  = "Tuk, B and Oberye, J J and Pieters, M S and Schoemaker, R C and
             Kemp, B and van Gerven, J and Danhof, M and Kamphuisen, H A and
             Cohen, A F and Breimer, D D and Peck, C C",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  62,
  number  =  4,
  pages   = "444--452",
  year    =  1997
}

@ARTICLE{De_Hoog1997-hs,
  title   = "Tobramycin population pharmacokinetics in neonates",
  author  = "de Hoog, M and Schoemaker, R C and Mouton, J W and van den Anker,
             J N",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  62,
  number  =  4,
  pages   = "392--399",
  year    =  1997
}

@ARTICLE{Samara1997-hp,
  title   = "Population analysis of the pharmacokinetics and pharmacodynamics
             of seratrodast in patients with mild to moderate asthma",
  author  = "Samara, E and Cao, G and Locke, C and Granneman, G R and Dean, R
             and Killian, A",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  62,
  number  =  4,
  pages   = "426--435",
  year    =  1997
}

@ARTICLE{Rydberg1997-gk,
  title   = "Concentration-effect relations of glibenclamide and its active
             metabolites in man: modelling of pharmacokinetics and
             pharmacodynamics",
  author  = "Rydberg, T and Jonsson, A and Karlsson, M O and Melander, A",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  43,
  number  =  4,
  pages   = "373--381",
  year    =  1997
}

@ARTICLE{Viele1997-rr,
  title   = "Recombinant human hemoglobin does not affect renal function in
             humans: analysis of safety and pharmacokinetics",
  author  = "Viele, M K and Weiskopf, R B and Fisher, D",
  journal = "Anesthesiology",
  volume  =  86,
  number  =  4,
  pages   = "848--858",
  year    =  1997
}

@ARTICLE{Piotrovskij1997-dd,
  title   = "A model with separate hepato-portal compartment (``first-pass''
             model): fitting to plasma concentration-time profiles in humans",
  author  = "Piotrovskij, V and Van Peer, A",
  journal = "Pharm. Res.",
  volume  =  14,
  number  =  2,
  pages   = "230--237",
  year    =  1997
}

@ARTICLE{Reynolds1997-ln,
  title   = "Bioavailability of intramuscular rocuronium in infants and
             children",
  author  = "Reynolds, L M and Lau, M and Brown, R and Luks, A and Sharma, M
             and Fisher, D M",
  journal = "Anesthesiology",
  volume  =  87,
  number  =  5,
  pages   = "1096--1105",
  year    =  1997
}

@ARTICLE{Fisher1997-fe,
  title   = "Pharmacokinetics of rocuronium during the three stages of liver
             transplantation",
  author  = "Fisher, D M and Ramsay, M A and Hein, H A and Marcel, R J and
             Sharma, M and Ramsay, K J and Miller, R D",
  journal = "Anesthesiology",
  volume  =  86,
  number  =  6,
  pages   = "1306--1316",
  year    =  1997
}

@ARTICLE{Fisher1997-vn,
  title   = "Are plasma concentration values necessary for pharmacodynamic
             modeling of muscle relaxants?",
  author  = "Fisher, D M and Wright, P M",
  journal = "Anesthesiology",
  volume  =  86,
  number  =  3,
  pages   = "567--575",
  year    =  1997
}

@ARTICLE{Talke1997-mz,
  title   = "Postoperative pharmacokinetics and sympatholytic effects of
             dexmedetomidine",
  author  = "Talke, P and Richardson, C A and Scheinin, M and Fisher, D M",
  journal = "Anesth. Analg.",
  volume  =  85,
  number  =  5,
  pages   = "1136--1142",
  year    =  1997
}

@ARTICLE{Troconiz1997-mk,
  title   = "Pharmacokinetic-pharmacodynamic modeling of mivacurium in rats",
  author  = "Troconiz, I F and Garrido, M J and Garcia, E and Suarez, E and
             Calvo, R",
  journal = "J. Pharm. Sci.",
  volume  =  86,
  number  =  2,
  pages   = "252--256",
  year    =  1997
}

@ARTICLE{Hempel1998-lj,
  title   = "Population pharmacokinetic-pharmacodynamic modeling of moxonidine
             using 24-hour ambulatory blood pressure measurements",
  author  = "Hempel, G and Karlsson, M O and de Alwis, D P and Toublanc, N and
             McNay, J and Schaefer, H G",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  64,
  number  =  6,
  pages   = "622--635",
  year    =  1998
}

@ARTICLE{Karlsson1998-sn,
  title   = "The population pharmacokinetics of recombinant- and urinary-human
             follicle stimulating hormone in women",
  author  = "Karlsson, M O and Wade, J R and Loumaye, E and Munafo, A",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  45,
  number  =  1,
  pages   = "13--20",
  year    =  1998
}

@ARTICLE{Gardmark1998-kc,
  title   = "Morphine-3-glucuronide has a minor effect on morphine
             antinociception. Pharmacodynamic modeling",
  author  = "Gardmark, M and Karlsson, M O and Jonsson, F and
             Hammarlund-Udenaes, M",
  journal = "J. Pharm. Sci.",
  volume  =  87,
  number  =  7,
  pages   = "813--820",
  year    =  1998
}

@ARTICLE{Karlsson1998-kv,
  title   = "A general model for time-dissociated
             pharmacokinetic-pharmacodynamic relationship exemplified by
             paclitaxel myelosuppression",
  author  = "Karlsson, M O and Molnar, V and Bergh, J and Freijs, A and
             Larsson, R",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  63,
  number  =  1,
  pages   = "11--25",
  year    =  1998
}

@ARTICLE{Brynne1998-ly,
  title   = "Concentration-effect relationship of l-propranolol and metoprolol
             in spontaneous hypertensive rats after exercise-induced
             {tachycardia.PG}",
  author  = "Brynne, L and Karlsson, M O and Paalzow, L K",
  journal = "J. Pharmacol. Exp. Ther.",
  volume  =  286,
  number  =  3,
  year    =  1998
}

@ARTICLE{Sundberg1998-ed,
  title   = "Kinetics of methylmercury and inorganic mercury in lactating and
             nonlactating mice",
  author  = "Sundberg, J and Jonsson, S and Karlsson, M O and Hallen, I P and
             Oskarsson, A",
  journal = "Toxicol. Appl. Pharmacol.",
  volume  =  151,
  number  =  2,
  pages   = "319--329",
  year    =  1998
}

@ARTICLE{Port1998-vo,
  title   = "Predicting the time course of haemoglobin in children treated with
             erythropoietin for renal anaemia",
  author  = "Port, R E and Ding, R W and Fies, T and Scharer, K",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  46,
  number  =  5,
  pages   = "461--466",
  year    =  1998
}

@ARTICLE{Weiskopf1998-fu,
  title   = "Human cardiovascular and metabolic response to acute, severe
             isovolemic anemia",
  author  = "Weiskopf, R B and Viele, M K and Feiner, J and Kelley, S and
             Lieberman, J and Noorani, M and Leung, J M and Fisher, D M and
             Murray, W R and Toy, P and Moore, M A",
  journal = "JAMA",
  volume  =  279,
  number  =  3,
  pages   = "217--221",
  year    =  1998
}

@ARTICLE{Wong1998-gb,
  title   = "Pharmacokinetics and pharmacodynamics of single and multiple oral
             doses of a novel 5-lipoxygenase inhibitor ({ABT-761}) in healthy
             {volunteers.PG}",
  author  = "Wong, S L and Drajesk, J and Chang, M and Lanni, C and Witt, G and
             Hansen, R and Awni, W M",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  63,
  number  =  3,
  year    =  1998
}

@ARTICLE{Szenohradszky1999-tx,
  title   = "Influence of renal failure on the pharmacokinetics and
             neuromuscular effects of a single dose of rapacuronium bromide",
  author  = "Szenohradszky, J and Caldwell, J E and Wright, P M and Brown, R
             and Lau, M and Luks, A M and Fisher, D M",
  journal = "Anesthesiology",
  volume  =  90,
  number  =  1,
  pages   = "24--35",
  year    =  1999
}

@ARTICLE{Tegeder1999-xc,
  title   = "Comparison of inhibitory effects of meloxicam and diclofenac on
             human thromboxane biosynthesis after single doses and at steady
             {state.PG}",
  author  = "Tegeder, I and Lotsch, J and Krebs, S and Muth-Selbach, U and
             Brune, K and Geisslinger, G",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  65,
  number  =  5,
  year    =  1999
}

@ARTICLE{Lalonde1999-vg,
  title   = "Mixed-effects modeling of the pharmacodynamic response to the
             calcimimetic agent {R-568}",
  author  = "Lalonde, R L and Gaudreault, J and Karhu, D A and Marriott, T B",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  65,
  number  =  1,
  pages   = "40--49",
  year    =  1999
}

@ARTICLE{Albrecht1999-ih,
  title   = "The effect of age on the pharmacokinetics and pharmacodynamics of
             midazolam",
  author  = "Albrecht, S and Ihmsen, H and Hering, W and Geisslinger, G and
             Dingemanse, J and Schwilden, H and Schuttler, J",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  65,
  number  =  6,
  pages   = "630--639",
  year    =  1999
}

@ARTICLE{Funaki1999-zc,
  title   = "Enterohepatic circulation model for population pharmacokinetic
             analysis",
  author  = "Funaki, T",
  journal = "J. Pharm. Pharmacol.",
  volume  =  51,
  number  =  10,
  pages   = "1143--1148",
  year    =  1999
}

@ARTICLE{Mould1999-ya,
  title   = "A population pharmacokinetic-pharmacodynamic analysis of single
             doses of clenoliximab in patients with rheumatoid arthritis",
  author  = "Mould, D R and Davis, C B and Minthorn, E A and Kwok, D C and
             Elliott, M J and Luggen, M E and Totoritis, M C",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  66,
  number  =  3,
  pages   = "246--257",
  year    =  1999
}

@ARTICLE{Fisher1999-sb,
  title   = "Factors affecting the pharmacokinetic characteristics of
             rapacuronium",
  author  = "Fisher, D M and Kahwaji, R and Bevan, D and Bikhazi, G and Fragen,
             R J and Angst, M S and Ornstein, E and Matteo, R S",
  journal = "Anesthesiology",
  volume  =  90,
  number  =  4,
  pages   = "993--1000",
  year    =  1999
}

@ARTICLE{Fisher1999-wx,
  title   = "The influence of renal function on the pharmacokinetics and
             pharmacodynamics and simulated time course of doxacurium",
  author  = "Fisher, D M and Reynolds, K S and Schmith, V D and Hsu, J and
             Sokoll, M D and Lennon, R L and Caldwell, J E",
  journal = "Anesth. Analg.",
  volume  =  89,
  number  =  3,
  pages   = "786--795",
  year    =  1999
}

@ARTICLE{Romson1999-ne,
  title   = "Effects of dobutamine on hemodynamics and left ventricular
             performance after cardiopulmonary bypass in cardiac surgical
             patients",
  author  = "Romson, J L and Leung, J M and Bellows, W H and Bronstein, M and
             Keith, F and Moores, W and Flachsbart, K and Richter, R and
             Pastor, D and Fisher, D M",
  journal = "Anesthesiology",
  volume  =  91,
  number  =  5,
  pages   = "1318--1328",
  year    =  1999
}

@ARTICLE{Karlsson1999-iu,
  title   = "Pharmacokinetic models for the saturable distribution of
             paclitaxel",
  author  = "Karlsson, M O and Molnar, V and Freijs, A and Nygren, P and Bergh,
             J and Larsson, R",
  journal = "Drug Metab. Dispos.",
  volume  =  27,
  number  =  10,
  pages   = "1220--1223",
  year    =  1999
}

@ARTICLE{Kemme2000-si,
  title   = "The influence of reduced liver blood flow on the pharmacokinetics
             and pharmacodynamics of recombinant tissue factor pathway
             {inhibitor.PG}",
  author  = "Kemme, M J and Burggraaf, J and Schoemaker, R C and Paulson, S and
             Karim, A and Lentjes, E G and Childs, A and Braeckman, R A and
             Cohen, A F",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  67,
  number  =  5,
  year    =  2000
}

@ARTICLE{Krecic-Shepard2000-ft,
  title   = "Race and sex influence clearance of nifedipine: results of a
             population study",
  author  = "Krecic-Shepard, M E and Park, K and Barnas, C and Slimko, J and
             Kerwin, D R and Schwartz, J B",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  68,
  number  =  2,
  pages   = "130--142",
  year    =  2000
}

@ARTICLE{Karlsson2000-dn,
  title   = "A pharmacodynamic Markov mixed-effects model for the effect of
             temazepam on sleep",
  author  = "Karlsson, M O and Schoemaker, R C and Kemp, B and Cohen, A F and
             van Gerven, J M and Tuk, B and Peck, C C and Danhof, M",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  68,
  number  =  2,
  pages   = "175--188",
  year    =  2000
}

@ARTICLE{Terret2000-bg,
  title   = "Dose and time dependencies of 5-fluorouracil pharmacokinetics",
  author  = "Terret, C and Erdociain, E and Guimbaud, R and Boisdron-Celle, M
             and McLeod, H L and Fety-Deporte, R and Lafont, T and Gamelin, E
             and Bugat, R and Canal, P and Chatelut, E",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  68,
  number  =  3,
  pages   = "270--279",
  year    =  2000
}

@ARTICLE{Friberg2000-wt,
  title   = "Models of schedule dependent haematological toxicity of
             2'-deoxy-2'-methylidenecytidine ({DMDC})",
  author  = "Friberg, L E and Brindley, C J and Karlsson, M O and Devlin, A J",
  journal = "Eur. J. Clin. Pharmacol.",
  volume  =  56,
  number  =  8,
  pages   = "567--574",
  year    =  2000
}

@ARTICLE{Brynne2000-sd,
  title   = "Consequence of exercise on the cardiovascular effects of
             l-propranolol in spontaneously hypertensive rats",
  author  = "Brynne, L and Paalzow, L K and Karlsson, M O",
  journal = "J. Pharmacol. Exp. Ther.",
  volume  =  294,
  number  =  3,
  pages   = "1201--1208",
  year    =  2000
}

@ARTICLE{Frame2001-wy,
  title   = "Population pharmacokinetics of clinafloxacin in healthy volunteers
             and patients with infections: experience with heterogeneous
             pharmacokinetic data",
  author  = "Frame, B and Koup, J and Miller, R and Lalonde, R",
  journal = "Clin. Pharmacokinet.",
  volume  =  40,
  number  =  4,
  pages   = "307--315",
  year    =  2001
}

@ARTICLE{Brynne2001-gn,
  title   = "Pharmacodynamic models for the cardiovascular effects of
             moxonidine in patients with congestive heart failure",
  author  = "Brynne, L and McNay, J L and Schaefer, H G and Swedberg, K and
             Wiltse, C G and Karlsson, M O",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  51,
  number  =  1,
  pages   = "35--43",
  year    =  2001
}

@ARTICLE{Cullberg2001-ee,
  title   = "Population modelling of the effect of inogatran, at thrombin
             inhibitor, on ex vivo coagulation time ({APTT}) in healthy
             subjects and patients with coronary artery disease",
  author  = "Cullberg, M and Eriksson, U G and Larsson, M and Karlsson, M O",
  journal = "Br. J. Clin. Pharmacol.",
  volume  =  51,
  number  =  1,
  pages   = "71--79",
  year    =  2001
}

@ARTICLE{Kovarik2001-jl,
  title   = "A population pharmacokinetic screen to identify
             demographic-clinical covariates of basiliximab in liver
             transplantation",
  author  = "Kovarik, J M and Nashan, B and Neuhaus, P and Clavien, P A and
             Gerbeau, C and Hall, M L and Korn, A",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  69,
  number  =  4,
  pages   = "201--209",
  year    =  2001
}

@ARTICLE{Mould2001-lk,
  title   = "A population pharmacokinetic-pharmacodynamic and logistic
             regression analysis of lotrafiban in patients",
  author  = "Mould, D and Chapelsky, M and Aluri, J and Swagzdis, J and
             Samuels, R and Granett, J",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  69,
  number  =  4,
  pages   = "210--222",
  year    =  2001
}

@ARTICLE{Ploeger2001-in,
  title   = "A population physiologically based pharmacokinetic/pharmacodynamic
             model for the inhibition of 11-beta-hydroxysteroid dehydrogenase
             activity by glycyrrhetic acid",
  author  = "Ploeger, B and Mensinga, T and Sips, A and Deerenberg, C and
             Meulenbelt, J and DeJongh, J",
  journal = "Toxicol. Appl. Pharmacol.",
  volume  =  170,
  number  =  1,
  pages   = "46--55",
  year    =  2001
}

@ARTICLE{Van_Zuylen2001-us,
  title   = "Pharmacokinetic modeling of paclitaxel encapsulation in Cremophor
             {EL} micelles",
  author  = "van Zuylen, L and Karlsson, M O and Verweij, J and Brouwer, E and
             de Bruijn, P and Nooter, K and Stoter, G and Sparreboom, A",
  journal = "Cancer Chemother. Pharmacol.",
  volume  =  47,
  number  =  4,
  pages   = "309--318",
  year    =  2001
}

@ARTICLE{Huitema2001-aa,
  title   = "A mechanism-based pharmacokinetic model for the cytochrome {P450}
             drug-drug interaction between cyclophosphamide and {thioTEPA} and
             the autoinduction of cyclophosphamide",
  author  = "Huitema, A D and Mathot, R A and Tibben, M M and Rodenhuis, S and
             Beijnen, J H",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  28,
  number  =  3,
  pages   = "211--230",
  year    =  2001
}

@ARTICLE{Jen2001-fq,
  title   = "Population pharmacokinetic analysis of pegylated interferon
             alfa-2b and interferon alfa-2b in patients with chronic hepatitis
             {C}",
  author  = "Jen, J F and Glue, P and Ezzet, F and Chung, C and Gupta, S K and
             Jacobs, S and Hajian, G",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  69,
  number  =  6,
  pages   = "407--421",
  year    =  2001
}

@ARTICLE{Rahman1999-yl,
  title   = "The Bayesian analysis of a pivotal pharmacokinetic study",
  author  = "Rahman, N J and Wakefield, J C and Stephens, D A and Falcoz, C",
  journal = "Stat. Methods Med. Res.",
  volume  =  8,
  number  =  3,
  pages   = "195--216",
  year    =  1999
}

@ARTICLE{Wakefield1997-vh,
  title   = "A population approach to initial dose selection",
  author  = "Wakefield, J and Walker, S",
  journal = "Stat. Med.",
  volume  =  16,
  number  =  10,
  pages   = "1135--1149",
  year    =  1997
}

@ARTICLE{Rosner1994-re,
  title   = "Pharmacodynamic analysis of hematologic profiles",
  author  = "Rosner, G L and Muller, P",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  22,
  number  =  6,
  pages   = "499--524",
  year    =  1994
}

@ARTICLE{Belin1995-jq,
  title   = "The analysis of repeated-measures data on schizophrenic reaction
             times using mixture models",
  author  = "Belin, T R and Rubin, D B",
  journal = "Stat. Med.",
  volume  =  14,
  number  =  8,
  pages   = "747--768",
  year    =  1995
}

@ARTICLE{Mallick1999-jg,
  title   = "Bayesian survival analysis using a {MARS} model",
  author  = "Mallick, B K and Denison, D G and Smith, A F",
  journal = "Biometrics",
  volume  =  55,
  number  =  4,
  pages   = "1071--1077",
  year    =  1999
}

@ARTICLE{Royston1999-tj,
  title   = "A new approach to modeling daily probabilities of conception",
  author  = "Royston, P and Ferreira, A",
  journal = "Biometrics",
  volume  =  55,
  number  =  4,
  pages   = "1005--1013",
  year    =  1999
}

@ARTICLE{Rosner1997-wx,
  title   = "Bayesian population pharmacokinetic and pharmacodynamic analyses
             using mixture models",
  author  = "Rosner, G L and Muller, P",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  25,
  number  =  2,
  pages   = "209--233",
  year    =  1997
}

@ARTICLE{Chouquet1999-ng,
  title   = "Timing of human immunodeficiency virus type 1 ({HIV-1})
             transmission from mother to child: bayesian estimation using a
             mixture",
  author  = "Chouquet, C and Richardson, S and Burgard, M and Blanche, S and
             Mayaux, M J and Rouzioux, C and Costagliola, D",
  journal = "Stat. Med.",
  volume  =  18,
  number  =  7,
  pages   = "815--833",
  year    =  1999
}

@ARTICLE{Ten_Have1999-db,
  title   = "Empirical Bayes estimation of random effects parameters in mixed
             effects logistic regression models",
  author  = "Ten Have, T R and Localio, A R",
  journal = "Biometrics",
  volume  =  55,
  number  =  4,
  pages   = "1022--1029",
  year    =  1999
}

@ARTICLE{Aarons1994-du,
  title   = "Population approaches in drug development. Report on an expert
             meeting to discuss population pharmacokinetic/pharmacodynamic
             software",
  author  = "Aarons, L and Balant, L P and Mentre, F and Morselli, P L and
             Rowland, M and Steimer, J L and Vozeh, S",
  journal = "Eur. J. Clin. Pharmacol.",
  volume  =  46,
  number  =  5,
  pages   = "389--391",
  year    =  1994
}

@ARTICLE{Zhou1997-nd,
  title   = "Confidence intervals for the log-normal mean",
  author  = "Zhou, X H and Gao, S",
  journal = "Stat. Med.",
  volume  =  16,
  number  =  7,
  pages   = "783--790",
  year    =  1997
}

@ARTICLE{Merle1999-dh,
  title   = "Optimal sampling times for Bayesian estimation of the
             pharmacokinetic parameters of nortriptyline during therapeutic
             drug monitoring",
  author  = "Merle, Y and Mentre, F",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  27,
  number  =  1,
  pages   = "85--101",
  year    =  1999
}

@ARTICLE{Wolfinger1998-tx,
  title   = "Tolerance intervals for variance component models using bayesian
             simulation",
  author  = "Wolfinger, R",
  journal = "J. Commod. Sci. Technol. Qual.",
  volume  =  30,
  number  =  1,
  pages   = "18--32",
  year    =  1998
}

@ARTICLE{Gelfand1990-tg,
  title   = "{Sampling-Based} approaches to calculating marginal densities",
  author  = "Gelfand, A E and Smith, A F",
  journal = "J. Am. Stat. Assoc.",
  volume  =  85,
  number  =  410,
  pages   = "398--409",
  year    =  1990
}

@ARTICLE{Gelfand1992-li,
  title   = "Bayesian analysis of constrained parameter and truncated data
             problems using Gibbs sampling",
  author  = "Gelfand, A E and Smith, A F and Lee, T",
  journal = "J. Am. Stat. Assoc.",
  volume  =  87,
  number  =  418,
  pages   = "523--532",
  year    =  1992
}

@ARTICLE{Gelman1992-iv,
  title   = "Inference from iterative simulation using multiple sequences",
  author  = "Gelman, A and Rubin, D B",
  journal = "Stat. Sci.",
  volume  =  7,
  number  =  4,
  pages   = "457--511",
  year    =  1992
}

@INCOLLECTION{Sheiner1983-rf,
  title     = "Analysis of Nonexperimental Pharmacokinetic Data",
  booktitle = "Drug absorption and disposition: statistical considerations",
  author    = "Sheiner, L B and Beal, S L and Albert, K S",
  publisher = "American Pharmaceutical Association",
  pages     = "31--49",
  year      =  1983,
  address   = "Washington D.C."
}

@ARTICLE{Yu1994-ph,
  title   = "A comparison of population and standard two-stage pharmacokinetic
             analyses of vigabatrin data",
  author  = "Yu, D K and Hutcheson, S J and Wei, G and Bhargava, V O and Weir,
             S J",
  journal = "Biopharm. Drug Dispos.",
  volume  =  15,
  number  =  6,
  pages   = "473--484",
  year    =  1994
}

@ARTICLE{Pinheiro1995-iu,
  title   = "Approximations to the log-likelihood function in the nonlinear
             mixed-effects model",
  author  = "Pinheiro, J and Bates, D M",
  journal = "J. Comput. Graph. Stat.",
  volume  =  4,
  number  =  1,
  pages   = "12--35",
  year    =  1995
}

@TECHREPORT{Pinheiro1995-fs,
  title       = "Model building for nonlinear mixed effects models",
  author      = "Pinheiro, Jose C and Bates, Douglas M",
  institution = "University of Wisconsin, Dept. of Biostatistics",
  month       =  may,
  year        =  1995
}

@ARTICLE{Wolfinger1993-uk,
  title   = "Laplace's approximation for nonlinear mixed models",
  author  = "Wolfinger, R",
  journal = "Biometrika",
  volume  =  80,
  number  =  4,
  pages   = "791--795",
  year    =  1993
}

@ARTICLE{Tierney1986-ci,
  title   = "Accurate Approximations for Posterior Moments and Marginal
             Densities",
  author  = "Tierney, L and Kadane, J",
  journal = "J. Am. Stat. Assoc.",
  volume  =  81,
  number  =  393,
  pages   = "82--86",
  year    =  1986
}

@INCOLLECTION{De_Bruijn1961-hy,
  title     = "Introduction",
  booktitle = "Asymptotic methods in analysis",
  author    = "de Bruijn, N G and de Groot, J and Zaanen, A",
  publisher = "North-Holland Publishing Co.",
  volume    = "second",
  pages     = "1--20",
  series    = "Bibliotheca Mathematica: A series of monographs on pure and
               applied mathematics",
  year      =  1961,
  address   = "Amsterdam"
}

@INCOLLECTION{De_Bruijn1961-zm,
  title     = "The Laplace method for integrals",
  booktitle = "Asymptotic methods in analysis",
  author    = "de Bruijn, N G and Bruijn, N G and de Groot, J and Zaanen, A",
  publisher = "North-Holland Publishing Co.",
  volume    = "second",
  pages     = "60--76",
  series    = "Bibliotheca Mathematica: A series of monographs on pure and
               applied mathematics",
  year      =  1961,
  address   = "Amsterdam"
}

@ARTICLE{Laird1982-ie,
  title   = "Random-effects models for longitudinal data",
  author  = "Laird, N M and Ware, J H",
  journal = "Biometrics",
  volume  =  38,
  number  =  4,
  pages   = "963--974",
  year    =  1982
}

@ARTICLE{Breslow1993-bq,
  title   = "Approximate inference in generalized linear mixed models",
  author  = "Breslow, N E and Clayton, D G",
  journal = "J. Am. Stat. Assoc.",
  volume  =  88,
  number  =  421,
  pages   = "9--25",
  year    =  1993
}

@ARTICLE{Lemmens1994-pi,
  title   = "Pharmacokinetic-pharmacodynamic modeling in drug development:
             application to the investigational opioid trefentanil",
  author  = "Lemmens, H J and Dyck, J B and Shafer, S L and Stanski, D R",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  56,
  number  =  3,
  pages   = "261--271",
  year    =  1994
}

@ARTICLE{Landaw1984-uu,
  title   = "Multiexponential, multicompartmental, and noncompartmental
             modeling. {II}. Data analysis and statistical considerations",
  author  = "Landaw, E M and DiStefano, J. J., I I I",
  journal = "Am. J. Physiol.",
  volume  =  246,
  number  = "5 Pt 2",
  pages   = "R665--R677",
  year    =  1984
}

@ARTICLE{Hinkley1977-bv,
  title   = "Jackknife confidence limits using student t approximations",
  author  = "Hinkley, D V",
  journal = "Biometrika",
  volume  =  64,
  number  =  1,
  pages   = "21--28",
  year    =  1977
}

@ARTICLE{Nestorov1999-dg,
  title   = "Sensitivity analysis of pharmacokinetic and pharmacodynamic
             systems: I. A structural approach to sensitivity analysis of
             physiologically based pharmacokinetic models",
  author  = "Nestorov, I A",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  27,
  number  =  6,
  pages   = "577--596",
  year    =  1999
}

@ARTICLE{Clewell1997-js,
  title   = "A physiologically based pharmacokinetic model for retinoic acid
             and its metabolites",
  author  = "Clewell, H. J., I I I and Andersen, M E and Wills, R J and
             Latriano, L",
  journal = "J. Am. Acad. Dermatol.",
  volume  =  36,
  number  = "3 Pt 2",
  pages   = "S77--S85",
  year    =  1997
}

@ARTICLE{Flores1999-gn,
  title   = "Pharmacogenetic variability in neuronal nicotinic
             receptor-mediated antinociception",
  author  = "Flores, C M and Wilson, S G and Mogil, J S",
  journal = "Pharmacogenetics",
  volume  =  9,
  number  =  5,
  pages   = "619--625",
  year    =  1999
}

@ARTICLE{Darby1997-ye,
  title   = "Risperidone dose and blood level variability: accumulation effects
             and interindividual and intraindividual variability in the
             nonresponder patient in the clinical practice setting",
  author  = "Darby, J K and Pasta, D J and Elfand, L and Dabiri, L and Clark, L
             and Herbert, J",
  journal = "J. Clin. Psychopharmacol.",
  volume  =  17,
  number  =  6,
  pages   = "478--484",
  year    =  1997
}

@ARTICLE{Poulin2000-rm,
  title   = "A priori prediction of tissue:plasma partition coefficients of
             drugs to facilitate the use of physiologically-based
             pharmacokinetic models in drug discovery",
  author  = "Poulin, P and Theil, F P",
  journal = "J. Pharm. Sci.",
  volume  =  89,
  number  =  1,
  pages   = "16--35",
  year    =  2000
}

@ARTICLE{Cook2000-rb,
  title   = "Identifying regression outliers and mixtures graphically",
  author  = "Cook, R D and Critchley, F",
  journal = "J. Am. Stat. Assoc.",
  volume  =  95,
  number  =  451,
  pages   = "781--794",
  year    =  2000
}

@ARTICLE{Chiou1989-hw,
  title   = "The phenomenon and rationale of marked dependence of drug
             concentration on blood sampling site. Implications in
             pharmacokinetics, pharmacodynamics, toxicology and therapeutics
             (Part I)",
  author  = "Chiou, W L",
  journal = "Clin. Pharmacokinet.",
  volume  =  17,
  number  =  3,
  pages   = "175--199",
  year    =  1989
}

@ARTICLE{Fitzgerald1991-cd,
  title   = "Narcotic analgesics in renal failure",
  author  = "Fitzgerald, J",
  journal = "Conn. Med.",
  volume  =  55,
  number  =  12,
  pages   = "701--704",
  year    =  1991
}

@ARTICLE{Chan1987-qz,
  title   = "Effects of renal insufficiency on the pharmacokinetics and
             pharmacodynamics of opioid analgesics",
  author  = "Chan, G L and Matzke, G R",
  journal = "Drug Intell. Clin. Pharm.",
  volume  =  21,
  number  =  10,
  pages   = "773--783",
  year    =  1987
}

@ARTICLE{Selz1991-tc,
  title   = "Bernoulli partition-equivalence of intermittent neuronal discharge
             patterns",
  author  = "Selz, K and Mandell, A",
  journal = "Int. J. Bifurcat. Chaos",
  volume  =  1,
  number  =  3,
  pages   = "717--722",
  year    =  1991
}

@ARTICLE{Yamaoka1978-rw,
  title   = "Application of Akaike's information criterion ({AIC}) in the
             evaluation of linear pharmacokinetic equations",
  author  = "Yamaoka, K and Nakagawa, T and Uno, T",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  6,
  number  =  2,
  pages   = "165--175",
  year    =  1978
}

@ARTICLE{Wilkinson1987-cp,
  title   = "Clearance approaches in pharmacology",
  author  = "Wilkinson, G R",
  journal = "Pharmacol. Rev.",
  volume  =  39,
  number  =  1,
  pages   = "1--47",
  year    =  1987
}

@ARTICLE{Karnes1991-vl,
  title   = "Validation of bioanalytical methods",
  author  = "Karnes, H T and Shiu, G and Shah, V P",
  journal = "Pharm. Res.",
  volume  =  8,
  number  =  4,
  pages   = "421--426",
  year    =  1991
}

@ARTICLE{Leff1988-ec,
  title   = "Analysis of agonist action using the operational model",
  author  = "Leff, P",
  journal = "Trends Pharmacol. Sci.",
  volume  =  9,
  number  =  11,
  pages   = "395--398",
  year    =  1988
}

@ARTICLE{Lindley1994-re,
  title   = "Pharmacokinetics and pharmacodynamics of recombinant factor {VIIa}",
  author  = "Lindley, C M and Sawyer, W T and Macik, B G and Lusher, J and
             Harrison, J F and Baird-Cox, K and Birch, K and Glazer, S and
             Roberts, H R",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  55,
  number  =  6,
  pages   = "638--648",
  year    =  1994
}

@ARTICLE{Efron1983-qw,
  title   = "Estimating the error rate of a prediction rule: improvement on
             cross-validation",
  author  = "Efron, B",
  journal = "J. Am. Stat. Assoc.",
  volume  =  78,
  number  =  382,
  pages   = "316--331",
  year    =  1983
}

@ARTICLE{Efron1994-qf,
  title   = "Missing data, imputation, and the bootstrap",
  author  = "Efron, B",
  journal = "J. Am. Stat. Assoc.",
  volume  =  89,
  number  =  426,
  pages   = "463--479",
  year    =  1994
}

@ARTICLE{Williams1990-fd,
  title   = "A physiologically relevant pharmacokinetic model of xenobiotic
             percutaneous absorption utilizing the isolated perfused porcine
             skin flap",
  author  = "Williams, P L and Carver, M P and Riviere, J E",
  journal = "J. Pharm. Sci.",
  volume  =  79,
  number  =  4,
  pages   = "305--311",
  year    =  1990
}

@ARTICLE{Zatz1992-dk,
  title   = "Simulation studies of skin permeation",
  author  = "Zatz, J",
  journal = "J. Soc. Cosmet. Chem.",
  volume  =  43,
  pages   = "37--48",
  year    =  1992
}

@ARTICLE{Conner1989-wd,
  title   = "Transcutaneous collection of theophylline: constancy and linearity
             of skin permeability",
  author  = "Conner, D P and Almirez, R G and Rhyne, P and Zamani, K and
             Bolden, B J and Peck, C C",
  journal = "Skin Pharmacol.",
  volume  =  2,
  number  =  3,
  pages   = "155--161",
  year    =  1989
}

@ARTICLE{Cleek1993-ky,
  title   = "A new method for estimating dermal absorption from chemical
             exposure. 1. General approach",
  author  = "Cleek, R L and Bunge, A L",
  journal = "Pharm. Res.",
  volume  =  10,
  number  =  4,
  pages   = "497--506",
  year    =  1993
}

@ARTICLE{Mordenti1986-ih,
  title   = "Man versus beast: pharmacokinetic scaling in mammals",
  author  = "Mordenti, J",
  journal = "J. Pharm. Sci.",
  volume  =  75,
  number  =  11,
  pages   = "1028--1040",
  year    =  1986
}

@ARTICLE{Mordenti1991-bj,
  title   = "Interspecies scaling of clearance and volume of distribution data
             for five therapeutic proteins",
  author  = "Mordenti, J and Chen, S A and Moore, J A and Ferraiolo, B L and
             Green, J D",
  journal = "Pharm. Res.",
  volume  =  8,
  number  =  11,
  pages   = "1351--1359",
  year    =  1991
}

@ARTICLE{Calabrese1986-hg,
  title   = "Animal extrapolation and the challenge of human heterogeneity",
  author  = "Calabrese, E J",
  journal = "J. Pharm. Sci.",
  volume  =  75,
  number  =  11,
  pages   = "1041--1046",
  year    =  1986
}

@ARTICLE{Dedrick1986-pz,
  title   = "Interspecies scaling of regional drug delivery",
  author  = "Dedrick, R L",
  journal = "J. Pharm. Sci.",
  volume  =  75,
  number  =  11,
  pages   = "1047--1052",
  year    =  1986
}

@ARTICLE{Mordenti1985-lg,
  title   = "Pharmacokinetic scale-up: accurate prediction of human
             pharmacokinetic profiles from animal data",
  author  = "Mordenti, J",
  journal = "J. Pharm. Sci.",
  volume  =  74,
  number  =  10,
  pages   = "1097--1099",
  year    =  1985
}

@ARTICLE{Patel1990-bb,
  title   = "Comparative pharmacokinetics and interspecies scaling of
             3'-azido-3'-deoxythymidine ({AZT}) in several mammalian species",
  author  = "Patel, B A and Boudinot, F D and Schinazi, R F and Gallo, J M and
             Chu, C K",
  journal = "J. Pharmacobiodyn.",
  volume  =  13,
  number  =  3,
  pages   = "206--211",
  year    =  1990
}

@ARTICLE{Travis1991-ie,
  title   = "Interspecies scaling of anesthetic potency",
  author  = "Travis, C C and Bowers, J C",
  journal = "Toxicol. Ind. Health",
  volume  =  7,
  number  =  4,
  pages   = "249--260",
  year    =  1991
}

@ARTICLE{Boxenbaum1984-dx,
  title   = "Interspecies pharmacokinetic scaling and the
             evolutionary-comparative paradigm",
  author  = "Boxenbaum, H",
  journal = "Drug Metab. Rev.",
  volume  =  15,
  number  = "5-6",
  pages   = "1071--1121",
  year    =  1984
}

@ARTICLE{Ings1990-ne,
  title   = "Interspecies scaling and comparisons in drug development and
             toxicokinetics",
  author  = "Ings, R M",
  journal = "Xenobiotica",
  volume  =  20,
  number  =  11,
  pages   = "1201--1231",
  year    =  1990
}

@ARTICLE{Monro1990-kx,
  title   = "Interspecies comparisons in toxicology: the utility and futility
             of plasma concentrations of the test substance",
  author  = "Monro, A M",
  journal = "Regul. Toxicol. Pharmacol.",
  volume  =  12,
  number  =  2,
  pages   = "137--160",
  year    =  1990
}

@ARTICLE{Boxenbaum1982-kl,
  title   = "Interspecies scaling, allometry, physiological time, and the
             ground plan of pharmacokinetics",
  author  = "Boxenbaum, H",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  10,
  number  =  2,
  pages   = "201--227",
  year    =  1982
}

@ARTICLE{Riond1990-bo,
  title   = "Allometric analysis of doxycycline pharmacokinetic parameters",
  author  = "Riond, J L and Riviere, J E",
  journal = "J. Vet. Pharmacol. Ther.",
  volume  =  13,
  number  =  4,
  pages   = "404--407",
  year    =  1990
}

@ARTICLE{Sawada1984-is,
  title   = "Prediction of the disposition of beta-lactam antibiotics in humans
             from pharmacokinetic parameters in animals",
  author  = "Sawada, Y and Hanano, M and Sugiyama, Y and Iga, T",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  12,
  number  =  3,
  pages   = "241--261",
  year    =  1984
}

@ARTICLE{Dedrick1980-ol,
  title   = "Species similarities in pharmacokinetics",
  author  = "Dedrick, R L and Bischoff, K B",
  journal = "Fed. Proc.",
  volume  =  39,
  number  =  1,
  pages   = "54--59",
  year    =  1980
}

@ARTICLE{Ruelius1987-fv,
  title   = "Extrapolation from animals to man: predictions, pitfalls and
             perspectives",
  author  = "Ruelius, H W",
  journal = "Xenobiotica",
  volume  =  17,
  number  =  3,
  pages   = "255--265",
  year    =  1987
}

@ARTICLE{Boxenbaum1983-fd,
  title   = "Interspecies pharmacokinetic scaling and the Dedrick plots",
  author  = "Boxenbaum, H and Ronfeld, R",
  journal = "Am. J. Physiol.",
  volume  =  245,
  number  =  6,
  pages   = "R768--R775",
  year    =  1983
}

@ARTICLE{Yates1986-qy,
  title   = "Similarity principles and intrinsic geometries: contrasting
             approaches to interspecies scaling",
  author  = "Yates, F E and Kugler, P N",
  journal = "J. Pharm. Sci.",
  volume  =  75,
  number  =  11,
  pages   = "1019--1027",
  year    =  1986
}

@ARTICLE{Boxenbaum1986-xb,
  title   = "Time concepts in physics, biology, and pharmacokinetics",
  author  = "Boxenbaum, H",
  journal = "J. Pharm. Sci.",
  volume  =  75,
  number  =  11,
  pages   = "1053--1062",
  year    =  1986
}

@ARTICLE{Colburn1988-ic,
  title   = "Physiologic pharmacokinetic modeling",
  author  = "Colburn, W A",
  journal = "J. Clin. Pharmacol.",
  volume  =  28,
  number  =  8,
  pages   = "673--677",
  year    =  1988
}

@ARTICLE{Somani1991-pp,
  title   = "Physiological pharmacokinetic and pharmacodynamic model of
             physostigmine in the rat",
  author  = "Somani, S M and Gupta, S K and Khalique, A and Unni, L K",
  journal = "Drug Metab. Dispos.",
  volume  =  19,
  number  =  3,
  pages   = "655--660",
  year    =  1991
}

@ARTICLE{Conolly1991-os,
  title   = "Biologically based pharmacodynamic models: tools for toxicological
             research and risk assessment",
  author  = "Conolly, R B and Andersen, M E",
  journal = "Annu. Rev. Pharmacol. Toxicol.",
  volume  =  31,
  pages   = "503--523",
  year    =  1991
}

@ARTICLE{Leung1990-fu,
  title   = "Cancer risk assessment for dioxane based upon a
             physiologically-based pharmacokinetic approach",
  author  = "Leung, H W and Paustenbach, D J",
  journal = "Toxicol. Lett.",
  volume  =  51,
  number  =  2,
  pages   = "147--162",
  year    =  1990
}

@ARTICLE{Young1978-sp,
  title   = "The dose-dependent fate of 1,4-dioxane in rats",
  author  = "Young, J D and Braun, W H and Gehring, P J",
  journal = "J. Environ. Pathol. Toxicol.",
  volume  =  2,
  number  =  2,
  pages   = "263--282",
  year    =  1978
}

@ARTICLE{Young1977-vg,
  title   = "Pharmacokinetics of 1,4-dioxane in humans",
  author  = "Young, J D and Braun, W H and Rampy, L W and Chenoweth, M B and
             Blau, G E",
  journal = "J. Toxicol. Environ. Health",
  volume  =  3,
  number  =  3,
  pages   = "507--520",
  year    =  1977
}

@ARTICLE{Ludden1991-nr,
  title   = "Application of population analysis to physiological
             pharmacokinetics",
  author  = "Ludden, T and Allerheiligen, S and Burk, R",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  19,
  number  =  3,
  pages   = "101S--113S",
  year    =  1991
}

@INCOLLECTION{Schwartz1993-mg,
  title     = "Physiologically based pharmacokinetic modelling of nicotine",
  booktitle = "Nicotine and related alkaloids: absorption, distribution,
               metabolism and excretion",
  author    = "Schwartz, S L and Gastonguay, M and Robinson, D E and Balter, N
               J and Gorrod, J W and Wahren, J",
  publisher = "Chapman and Hall",
  pages     = "267--286",
  year      =  1993,
  address   = "London"
}

@ARTICLE{Gearhart1990-mn,
  title   = "Physiologically based pharmacokinetic and pharmacodynamic model
             for the inhibition of acetylcholinesterase by
             diisopropylfluorophosphate",
  author  = "Gearhart, J M and Jepson, G W and Clewell, H. J., I I I and
             Andersen, M E and Conolly, R B",
  journal = "Toxicol. Appl. Pharmacol.",
  volume  =  106,
  number  =  2,
  pages   = "295--310",
  year    =  1990
}

@ARTICLE{Bernareggi1991-me,
  title   = "Physiologic modeling of cyclosporin kinetics in rat and man",
  author  = "Bernareggi, A and Rowland, M",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  19,
  number  =  1,
  pages   = "21--50",
  year    =  1991
}

@ARTICLE{Bjorkman1993-nx,
  title   = "Tissue distribution of fentanyl and alfentanil in the rat cannot
             be described by a blood flow limited model",
  author  = "Bjorkman, S and Stanski, D R and Harashima, H and Dowrie, R and
             Harapat, S R and Wada, D R and Ebling, W F",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  21,
  number  =  3,
  pages   = "255--279",
  year    =  1993
}

@ARTICLE{Frederick1992-ab,
  title   = "A physiologically based pharmacokinetic and pharmacodynamic model
             to describe the oral dosing of rats with ethyl acrylate and its
             implications for risk assessment",
  author  = "Frederick, C B and Potter, D W and Chang-Mateu, M I and Andersen,
             M E",
  journal = "Toxicol. Appl. Pharmacol.",
  volume  =  114,
  number  =  2,
  pages   = "246--260",
  year    =  1992
}

@ARTICLE{Andersen1989-sf,
  title   = "Tissue dosimetry, physiologically-based pharmacokinetic modeling,
             and cancer risk assessment",
  author  = "Andersen, M E",
  journal = "Cell Biol. Toxicol.",
  volume  =  5,
  number  =  4,
  pages   = "405--415",
  year    =  1989
}

@ARTICLE{Gerlowski1983-tz,
  title   = "Physiologically based pharmacokinetic modeling: principles and
             applications",
  author  = "Gerlowski, L E and Jain, R K",
  journal = "J. Pharm. Sci.",
  volume  =  72,
  number  =  10,
  pages   = "1103--1127",
  year    =  1983
}

@ARTICLE{Adolph1949-mw,
  title   = "Quantitative relations in the physiological constitutions of
             mammals",
  author  = "Adolph, E F",
  journal = "Science",
  volume  =  109,
  pages   = "579--585",
  year    =  1949
}

@ARTICLE{Dedrick1973-sm,
  title   = "Animal scale-up",
  author  = "Dedrick, R L",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  1,
  number  =  5,
  pages   = "435--461",
  year    =  1973
}

@ARTICLE{Medina1991-pf,
  title   = "Animal-to-human extrapolation using compartmental models",
  author  = "Medina, R L and Albanese, R A",
  journal = "Neurosci. Biobehav. Rev.",
  volume  =  15,
  number  =  1,
  pages   = "57--61",
  year    =  1991
}

@ARTICLE{Smith1991-ec,
  title   = "Species differences in metabolism and pharmacokinetics: are we
             close to an understanding?",
  author  = "Smith, D A",
  journal = "Drug Metab. Rev.",
  volume  =  23,
  number  = "3-4",
  pages   = "355--373",
  year    =  1991
}

@ARTICLE{Mackay1988-hq,
  title   = "Concentration-response curves and receptor classification: null
             method or operational model?",
  author  = "Mackay, D",
  journal = "Trends Pharmacol. Sci.",
  volume  =  9,
  number  =  6,
  pages   = "202--205",
  year    =  1988
}

@ARTICLE{Atkinson1991-hw,
  title   = "Physiological basis of multicompartmental models of drug
             distribution",
  author  = "Atkinson, A. J., Jr and Ruo, T I and Frederiksen, M C",
  journal = "Trends Pharmacol. Sci.",
  volume  =  12,
  number  =  3,
  pages   = "96--101",
  year    =  1991
}

@ARTICLE{Ben_David1993-gc,
  title   = "Torsades de pointes and proarrhythmia",
  author  = "Ben David, J and Zipes, D P",
  journal = "Lancet",
  volume  =  341,
  number  =  8860,
  pages   = "1578--1582",
  year    =  1993
}

@ARTICLE{Ito1991-ma,
  title   = "Kinetic evaluation for measurement of in vivo receptor occupancy
             by psychotropic drug in brain: implication for human studies",
  author  = "Ito, K and Sawada, Y and Sugiyama, Y and Hanano, M and Iga, T",
  journal = "Chem. Pharm. Bull.",
  volume  =  39,
  number  =  7,
  pages   = "1813--1819",
  year    =  1991
}

@ARTICLE{Kates1980-ui,
  title   = "A model to describe myocardial drug disposition in the dog",
  author  = "Kates, R E and Jaillon, P",
  journal = "J. Pharmacol. Exp. Ther.",
  volume  =  214,
  number  =  1,
  pages   = "31--36",
  year    =  1980
}

@ARTICLE{Herbette1988-jt,
  title   = "Possible molecular basis for the pharmacokinetics and
             pharmacodynamics of three membrane-active drugs: propranolol,
             nimodipine and amiodarone",
  author  = "Herbette, L G and Trumbore, M and Chester, D W and Katz, A M",
  journal = "J. Mol. Cell. Cardiol.",
  volume  =  20,
  number  =  5,
  pages   = "373--378",
  year    =  1988
}

@ARTICLE{Bungay1990-sq,
  title   = "Steady-state theory for quantitative microdialysis of solutes and
             water in vivo and in vitro",
  author  = "Bungay, P M and Morrison, P F and Dedrick, R L",
  journal = "Life Sci.",
  volume  =  46,
  number  =  2,
  pages   = "105--119",
  year    =  1990
}

@ARTICLE{Stahle1991-yj,
  title   = "Drug distribution studies with microdialysis. {III}: Extracellular
             concentration of caffeine in adipose tissue in man",
  author  = "Stahle, L and Arner, P and Ungerstedt, U",
  journal = "Life Sci.",
  volume  =  49,
  number  =  24,
  pages   = "1853--1858",
  year    =  1991
}

@ARTICLE{Stahle1991-nd,
  title   = "Drug distribution studies with microdialysis. {II}. Caffeine and
             theophylline in blood, brain and other tissues in rats",
  author  = "Stahle, L and Segersvard, S and Ungerstedt, U",
  journal = "Life Sci.",
  volume  =  49,
  number  =  24,
  pages   = "1843--1852",
  year    =  1991
}

@ARTICLE{Stahle1991-xu,
  title   = "Drug distribution studies with microdialysis: I. Tissue dependent
             difference in recovery between caffeine and theophylline",
  author  = "Stahle, L",
  journal = "Life Sci.",
  volume  =  49,
  number  =  24,
  pages   = "1835--1842",
  year    =  1991
}

@ARTICLE{Scott1991-hr,
  title   = "In vivo microdialysis sampling for pharmacokinetic investigations",
  author  = "Scott, D O and Sorenson, L R and Steele, K L and Puckett, D L and
             Lunte, C E",
  journal = "Pharm. Res.",
  volume  =  8,
  number  =  3,
  pages   = "389--392",
  year    =  1991
}

@ARTICLE{Khor1991-xf,
  title   = "Potential error in the measurement of tissue to blood distribution
             coefficients in physiological pharmacokinetic modeling. Residual
             tissue blood. {II}. Distribution of phencyclidine in the rat",
  author  = "Khor, S P and Bozigian, H and Mayersohn, M",
  journal = "Drug Metab. Dispos.",
  volume  =  19,
  number  =  2,
  pages   = "486--490",
  year    =  1991
}

@ARTICLE{Khor1991-ur,
  title   = "Potential error in the measurement of tissue to blood distribution
             coefficients in physiological pharmacokinetic modeling. Residual
             tissue blood. I. Theoretical considerations",
  author  = "Khor, S P and Mayersohn, M",
  journal = "Drug Metab. Dispos.",
  volume  =  19,
  number  =  2,
  pages   = "478--485",
  year    =  1991
}

@ARTICLE{Lam1982-ih,
  title   = "Determination of tissue to blood partition coefficients in
             physiologically-based pharmacokinetic studies",
  author  = "Lam, G and Chen, M L and Chiou, W L",
  journal = "J. Pharm. Sci.",
  volume  =  71,
  number  =  4,
  pages   = "454--456",
  year    =  1982
}

@ARTICLE{Davies1993-es,
  title   = "Physiological parameters in laboratory animals and humans",
  author  = "Davies, B and Morris, T",
  journal = "Pharm. Res.",
  volume  =  10,
  number  =  7,
  pages   = "1093--1095",
  year    =  1993
}

@ARTICLE{Williams1989-gg,
  title   = "Reference values for resting blood flow to organs of man",
  author  = "Williams, L R and Leggett, R W",
  journal = "Clin. Phys. Physiol. Meas.",
  volume  =  10,
  number  =  3,
  pages   = "187--217",
  year    =  1989
}

@ARTICLE{Leggett1991-lv,
  title   = "Suggested reference values for regional blood volumes in humans",
  author  = "Leggett, R W and Williams, L R",
  journal = "Health Phys.",
  volume  =  60,
  number  =  2,
  pages   = "139--154",
  year    =  1991
}

@TECHREPORT{Arms1988-tf,
  title  = "{EPA} Final Report: reference physiological parameters in
            pharmacokinetic modeling",
  author = "Arms, A D and Travis, C C",
  month  =  feb,
  year   =  1988
}

@TECHREPORT{Lai2000-um,
  title       = "Sequential analysis: some classical problems and new
                 challenges",
  author      = "Lai, T L",
  institution = "Department of Statistics, Stanford University",
  month       =  sep,
  year        =  2000
}

@ARTICLE{Gu1999-dy,
  title   = "Determination of power and sample size in the design of clinical
             trials with failure-time endpoints and interim analyses",
  author  = "Gu, M and Lai, T L",
  journal = "Control. Clin. Trials",
  volume  =  20,
  pages   = "423--438",
  year    =  1999
}

@ARTICLE{Gu1998-jc,
  title   = "Repeated significance testing with censored rank statistics in
             interim analysis of clinical trials",
  author  = "Gu, M and Lai, T L",
  journal = "Stat. Sin.",
  volume  =  8,
  pages   = "411--428",
  year    =  1998
}

@ARTICLE{Lai1985-xb,
  title   = "Regression analysis of compartmental models",
  author  = "Lai, T L",
  journal = "J. Res. Natl. Bur. Stand.",
  volume  =  90,
  number  =  6,
  pages   = "525--530",
  year    =  1985
}

@ARTICLE{Lai1994-rr,
  title   = "Statistical analysis of ligand-binding experiments",
  author  = "Lai, T L and Zhang, L",
  journal = "Biometrics",
  volume  =  50,
  number  =  3,
  pages   = "782--797",
  year    =  1994
}

@TECHREPORT{Lai2000-ku,
  title       = "Statistics in pharmacology and pre-clinical studies",
  author      = "Lai, T L and Shih, M and Zhu, G",
  institution = "Department of Statistics, Stanford University",
  month       =  sep,
  year        =  2000
}

@ARTICLE{Kasai1999-pv,
  title   = "Population pharmacokinetic analysis of pirmenol in healthy
             volunteers and patients with arrhythmia",
  author  = "Kasai, H and Ueno, K and Kusumoto, M and Shibakawa, M",
  journal = "Eur. J. Clin. Pharmacol.",
  volume  =  55,
  number  =  1,
  pages   = "77--78",
  year    =  1999
}

@ARTICLE{Hauck2000-pw,
  title   = "Subject-by-formulation interaction in bioequivalence: conceptual
             and statistical issues. {FDA} {Population/Individual}
             Bioequivalence Working Group. Food and Drug Administration",
  author  = "Hauck, W W and Hyslop, T and Chen, M L and Patnaik, R and
             Williams, R L",
  journal = "Pharm. Res.",
  volume  =  17,
  number  =  4,
  pages   = "375--380",
  year    =  2000
}

@ARTICLE{Meyer2000-he,
  title   = "Bioequivalence of methylphenidate immediate-release tablets using
             a replicated study design to characterize intrasubject variability",
  author  = "Meyer, M C and Straughn, A B and Jarvi, E J and Patrick, K S and
             Pelsor, F R and Williams, R L and Patnaik, R and Chen, M L and
             Shah, V P",
  journal = "Pharm. Res.",
  volume  =  17,
  number  =  4,
  pages   = "381--384",
  year    =  2000
}

@ARTICLE{Yafune1999-qr,
  title   = "Bootstrap approach for constructing confidence intervals for
             population pharmacokinetic parameters. I: A use of bootstrap
             standard error",
  author  = "Yafune, A and Ishiguro, M",
  journal = "Stat. Med.",
  volume  =  18,
  number  =  5,
  pages   = "581--599",
  year    =  1999
}

@ARTICLE{Yafune1999-yq,
  title   = "Bootstrap approach for constructing confidence intervals for
             population pharmacokinetic parameters. {II}: A bootstrap
             modification of standard two-stage ({STS}) method for phase {I}
             trial",
  author  = "Yafune, A and Ishiguro, M",
  journal = "Stat. Med.",
  volume  =  18,
  number  =  5,
  pages   = "601--612",
  year    =  1999
}

@ARTICLE{Edwards1999-cv,
  title   = "6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange
             juice: effects on cyclosporine disposition, enterocyte {CYP3A4},
             and P-glycoprotein",
  author  = "Edwards, D J and Fitzsimmons, M E and Schuetz, E G and Yasuda, K
             and Ducharme, M P and Warbasse, L H and Woster, P M and Schuetz, J
             D and Watkins, P",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  65,
  number  =  3,
  pages   = "237--244",
  year    =  1999
}

@ARTICLE{Sviri1999-ko,
  title   = "Phenotypic-genotypic analysis of {CYP2C19} in the Jewish Israeli
             population",
  author  = "Sviri, S and Shpizen, S and Leitersdorf, E and Levy, M and Caraco,
             Y",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  65,
  number  =  3,
  pages   = "275--282",
  year    =  1999
}

@ARTICLE{Chakraborty1999-rx,
  title   = "Pharmacoimmunodynamic interactions of interleukin-10 and
             prednisone in healthy volunteers",
  author  = "Chakraborty, A and Blum, R A and Cutler, D L and Jusko, W J",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  65,
  number  =  3,
  pages   = "304--318",
  year    =  1999
}

@ARTICLE{Mathot1999-uw,
  title   = "Pharmacodynamic modeling of the acid inhibitory effect of
             ranitidine in patients in an intensive care unit during prolonged
             dosing: characterization of tolerance",
  author  = "Mathot, R A and Geus, W P",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  66,
  number  =  2,
  pages   = "140--151",
  year    =  1999
}

@ARTICLE{Kramar1999-hf,
  title   = "Continual reassessment methods in phase {I} trials of the
             combination of two drugs in oncology",
  author  = "Kramar, A and Lebecq, A and Candalh, E",
  journal = "Stat. Med.",
  volume  =  18,
  number  =  14,
  pages   = "1849--1864",
  year    =  1999
}

@ARTICLE{Knatterud1998-zc,
  title   = "Guidelines for quality assurance in multicenter trials: a position
             paper",
  author  = "Knatterud, G L and Rockhold, F W and George, S L and Barton, F B
             and Davis, C E and Fairweather, W R and Honohan, T and Mowery, R
             and O'Neill, R",
  journal = "Control. Clin. Trials",
  volume  =  19,
  number  =  5,
  pages   = "477--493",
  year    =  1998
}

@ARTICLE{Albert1999-qs,
  title   = "Longitudinal data analysis (repeated measures) in clinical trials",
  author  = "Albert, P S",
  journal = "Stat. Med.",
  volume  =  18,
  number  =  13,
  pages   = "1707--1732",
  year    =  1999
}

@ARTICLE{Iyer1999-mw,
  title   = "In vitro characterization of the erythrocyte distribution of
             methazolamide: a model of erythrocyte transport and binding
             kinetics",
  author  = "Iyer, G R and Bellantone, R A and Taft, D R",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  27,
  number  =  1,
  pages   = "45--66",
  year    =  1999
}

@ARTICLE{Psaty1999-nq,
  title   = "Surrogate end points, health outcomes, and the drug-approval
             process for the treatment of risk factors for cardiovascular
             disease",
  author  = "Psaty, B M and Weiss, N S and Furberg, C D and Koepsell, T D and
             Siscovick, D S and Rosendaal, F R and Smith, N L and Heckbert, S R
             and Kaplan, R C and Lin, D and Fleming, T R and Wagner, E H",
  journal = "JAMA",
  volume  =  282,
  number  =  8,
  pages   = "786--790",
  year    =  1999
}

@ARTICLE{Ferron1999-ro,
  title   = "Pharmacokinetic and pharmacoimmunodynamic interactions between
             prednisolone and sirolimus in adrenalectomized rats",
  author  = "Ferron, G M and Pyszczynski, N A and Jusko, W J",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  27,
  number  =  1,
  pages   = "1--21",
  year    =  1999
}

@ARTICLE{Amisaki1999-xz,
  title   = "A comparison of methods for estimating individual pharmacokinetic
             parameters",
  author  = "Amisaki, T and Eguchi, S",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  27,
  number  =  1,
  pages   = "103--121",
  year    =  1999
}

@ARTICLE{Upton1999-sa,
  title   = "The relationship between the myocardial kinetics of meperidine and
             its effect on myocardial contractility: model-independent analysis
             and optimal regional model",
  author  = "Upton, R N and Huang, Y F and Mather, L E and Doolette, D J",
  journal = "J. Pharmacol. Exp. Ther.",
  volume  =  290,
  number  =  2,
  pages   = "694--701",
  year    =  1999
}

@ARTICLE{Lin1999-sv,
  title   = "Is the role of the small intestine in first-pass metabolism
             overemphasized?",
  author  = "Lin, J H and Chiba, M and Baillie, T A",
  journal = "Pharmacol. Rev.",
  volume  =  51,
  number  =  2,
  pages   = "135--158",
  year    =  1999
}

@ARTICLE{Gozzi1999-op,
  title   = "Pharmacokinetic-pharmacodynamic modeling of the immunomodulating
             agent susalimod and experimentally induced tumor necrosis
             factor-alpha levels in the mouse",
  author  = "Gozzi, P and Pahlman, I and Palmer, L and Gronberg, A and Persson,
             S",
  journal = "J. Pharmacol. Exp. Ther.",
  volume  =  291,
  number  =  1,
  pages   = "199--203",
  year    =  1999
}

@ARTICLE{Warrington2000-od,
  title   = "Effects of age on in vitro midazolam biotransformation in male
             {CD-1} mouse liver microsomes",
  author  = "Warrington, J S and Poku, J W and von Moltke, L L and Shader, R I
             and Harmatz, J S and Greenblatt, D J",
  journal = "J. Pharmacol. Exp. Ther.",
  volume  =  292,
  number  =  3,
  pages   = "1024--1031",
  year    =  2000
}

@ARTICLE{Yamano2000-zr,
  title   = "Quantitative prediction of metabolic inhibition of midazolam by
             erythromycin, diltiazem, and verapamil in rats: implication of
             concentrative uptake of inhibitors into liver",
  author  = "Yamano, K and Yamamoto, K and Kotaki, H and Takedomi, S and
             Matsuo, H and Sawada, Y and Iga, T",
  journal = "J. Pharmacol. Exp. Ther.",
  volume  =  292,
  number  =  3,
  pages   = "1118--1126",
  year    =  2000
}

@ARTICLE{Singh1999-ms,
  title   = "Development of in vivo bioequivalence methodology for dermatologic
             corticosteroids based on pharmacodynamic modeling",
  author  = "Singh, G J and Adams, W P and Lesko, L J and Shah, V P and Molzon,
             J A and Williams, R L and Pershing, L K",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  66,
  number  =  4,
  pages   = "346--357",
  year    =  1999
}

@ARTICLE{Bellazzi1993-hb,
  title   = "Drug delivery optimization through Bayesian networks: an
             application to erythropoietin therapy in uremic anemia",
  author  = "Bellazzi, R",
  journal = "Comput. Biomed. Res.",
  volume  =  26,
  number  =  3,
  pages   = "274--293",
  year    =  1993
}

@INCOLLECTION{Jelliffe1986-ne,
  title     = "Clinical applications of pharmacokinetics and control theory:
               planning, monitoring, and adjusting dosage regimens of
               aminoglycosides, lidocaine, digitoxin, and digoxin",
  booktitle = "Selected topics in clinical pharmacology",
  author    = "Jelliffe, R W and Maronde, R",
  publisher = "Springer-Verlag",
  pages     = "26--82",
  year      =  1986,
  address   = "New York"
}

@ARTICLE{DArgenio1983-ez,
  title   = "Adaptive control of theophylline therapy: importance of blood
             sampling times",
  author  = "D'Argenio, D Z and Khakmahd, K",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  11,
  number  =  5,
  pages   = "547--559",
  year    =  1983
}

@ARTICLE{Katz1986-fx,
  title   = "Implementation and evaluation of control strategies for
             individualizing dosage regimens, with application to the
             aminoglycoside antibiotics",
  author  = "Katz, D and D'Argenio, D Z",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  14,
  number  =  5,
  pages   = "523--537",
  year    =  1986
}

@ARTICLE{Dodge1991-bt,
  title   = "Gentamicin population pharmacokinetic models for low birth weight
             infants using a new nonparametric method",
  author  = "Dodge, W F and Jelliffe, R W and Richardson, C J and McCleery, R A
             and Hokanson, J A and Snodgrass, W R",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  50,
  number  =  1,
  pages   = "25--31",
  year    =  1991
}

@ARTICLE{Messori1992-zs,
  title   = "{PKRD}: a pharmacokinetic program for least-squares and bayesian
             analysis of repeated-dose pharmacokinetic curves",
  author  = "Messori, A and Bosi, A and Guidi, S and Longo, G and Pistolesi, C
             and Saccardi, R and Valenza, T and Vannucchi, A M",
  journal = "Comput. Methods Programs Biomed.",
  volume  =  38,
  number  =  1,
  pages   = "27--35",
  year    =  1992
}

@ARTICLE{Spector1988-wn,
  title   = "Therapeutic drug monitoring",
  author  = "Spector, R and Park, G D and Johnson, G F and Vesell, E S",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  43,
  number  =  4,
  pages   = "345--353",
  year    =  1988
}

@INCOLLECTION{Beal1985-ip,
  title     = "Methodology of population pharmacokinetics",
  booktitle = "Drug fate and metabolism: methods and techniques",
  author    = "Beal, S and Sheiner, L B and Garrett, E R and Hirtz, J",
  publisher = "Marcel Decker",
  pages     = "135--183",
  year      =  1985,
  address   = "New York"
}

@INCOLLECTION{Whiting1990-gr,
  title     = "Population pharmacokinetics",
  booktitle = "Comprehensive medicinal chemistry",
  author    = "Whiting, B and Kelman, A and Grevel, J and Taylor, J B",
  publisher = "Pergamon Press",
  pages     = "297--304",
  year      =  1990,
  address   = "Oxford"
}

@INCOLLECTION{Whiting1992-dd,
  title     = "The population approach: applications to date. An overview",
  booktitle = "New strategies in drug development and clinical evaluation: the
               population approach",
  author    = "Whiting, B and Rowland, M and Aarons, L",
  publisher = "Commission of the European Communities",
  pages     = "41--58",
  year      =  1992,
  address   = "Brussels"
}

@TECHREPORT{Beal1984-da,
  title       = "Asymptotic properties of optimization estimators for the
                 independent not identically distributed case with application
                 to extended least squares estimators",
  author      = "Beal, S",
  institution = "University of California at San Francisco",
  year        =  1984
}

@ARTICLE{Lindstrom1984-un,
  title   = "Estimation of population pharmacokinetic parameters using
             destructively obtained experimental data: a simulation study of
             the one-compartment open model",
  author  = "Lindstrom, F T and Birkes, D S",
  journal = "Drug Metab. Rev.",
  volume  =  15,
  number  = "1-2",
  pages   = "195--264",
  year    =  1984
}

@ARTICLE{McArthur1988-dy,
  title   = "Parameter estimation in a two-compartmental population
             pharmacokinetic model with destructive sampling",
  author  = "McArthur, R D",
  journal = "Math. Biosci.",
  volume  =  91,
  pages   = "157--173",
  year    =  1988
}

@ARTICLE{Beal1991-le,
  title   = "Computing initial estimates with mixed effects models: a general
             method of moments",
  author  = "Beal, S L",
  journal = "Biometrika",
  volume  =  78,
  pages   = "217--220",
  year    =  1991
}

@ARTICLE{Grasela1991-sn,
  title   = "Pharmacostatistical modeling for observational data",
  author  = "Grasela, T H and Sheiner, L B",
  journal = "J. Pharmacokinet. Biopharm.",
  volume  =  19,
  pages   = "25S--35S",
  year    =  1991
}

@INCOLLECTION{Vozeh1992-fr,
  title     = "Applications of the population approach to clinical
               pharmacokinetics and validation of the results",
  booktitle = "New strategies in drug development and clinical evaluation: the
               population approach",
  author    = "Vozeh, S and Rowland, M and Aarons, L",
  publisher = "Commission of the European Communities",
  pages     = "107--124",
  year      =  1992,
  address   = "Brussels"
}

@INCOLLECTION{Olson1992-od,
  title     = "Population pharmacokinetics during drug development: esperience
               within {Parke-Davis}",
  booktitle = "New strategies in drug development and clinical evaluation: the
               population approach",
  author    = "Olson, S C and Rowland, M and Aarons, L",
  publisher = "Commission of the European Communities",
  pages     = "143--152",
  year      =  1992,
  address   = "Brussels"
}

@INCOLLECTION{Sambol1992-hn,
  title     = "The population approach: applications to experimental data",
  booktitle = "New strategies in drug development and clinical evaluation: the
               population approach",
  author    = "Sambol, N C and Rowland, M and Aarons, L",
  publisher = "Commission of the European Communities",
  pages     = "183--191",
  year      =  1992,
  address   = "Brussels"
}

@INCOLLECTION{Holford1992-ek,
  title     = "Parametric models for the time course of drug action: the
               population approach",
  booktitle = "New strategies in drug development and clinical evaluation: the
               population approach",
  author    = "Holford, N G and Rowland, M and Aarons, L",
  publisher = "Commission of the European Communities",
  pages     = "193--206",
  year      =  1992,
  address   = "Brussels"
}

@INCOLLECTION{Tanigawara1992-dg,
  title     = "Population approach in post-marketing dose adjustment",
  booktitle = "New strategies in drug development and clinical evaluation: the
               population approach",
  author    = "Tanigawara, Y and Rowland, M and Aarons, L",
  publisher = "Commission of the European Communities",
  pages     = "223--231",
  year      =  1992,
  address   = "Brussels"
}

@ARTICLE{Lindsay19

license: MIT

license_type: permissive

branch_name: refs/heads/master

extension: bib