text:
) nutritional status. In conclusion, vitamin/mineral deficiencies are still common in newly "early diagnosed" CD-patients, even though the prevalence of obesity at initial diagnosis is rising. Extensive nutritional assessments seem warranted to guide nutritional advices and follow-up in CD treatment.},
   keywords = {Adolescent
Adult
Aged
Body Mass Index
Case-Control Studies
Celiac Disease/blood/complications/*diagnosis
Cohort Studies
Diet, Gluten-Free
Female
Ferritins/blood
Folic Acid/blood
Hemoglobins/metabolism
Humans
Male
Micronutrients/*administration & dosage/*deficiency
Middle Aged
Netherlands/epidemiology
*Nutritional Status
Obesity/blood/complications/epidemiology
Prevalence
Vitamin A/blood
Vitamin B 12/blood
Vitamin B 6/blood
Vitamin D/blood
Weight Loss
Young Adult
Zinc/blood},
   ISSN = {2072-6643},
   Accession Number = {24084055},
   DOI = {10.3390/nu5103975},
   year = {2013},
   type = {Ref–rence Type}
}

@article{
   author = {Winter, M. D. and Londono, L. and Berry, C. R. and Hernandez, J. A.},
   title = {Ultrasonographic evaluation of relative gastrointestinal layer thickness in cats without clinical evidence of gastrointestinal tract disease},
   journal = {J Feline Med Surg},
   volume = {16},
   number = {2},
   pages = {118-24},
   note = {1532-2750
Winter, Matthew D
Londono, Leonel
Berry, Clifford R
Hernandez, Jorge A
Journal Article
Research Support, Non-U.S. Gov't
England
J Feline Med Surg. 2014 Feb;16(2):118-24. doi: 10.1177/1098612X13499013. Epub 2013 Aug 1.},
   abstract = {The objectives of this study were (1) to measure normal thickness values of the muscularis, submucosal, mucosal and serosal layers in each gastrointestinal (GI) segment (gastric fundus, body and pyloric antrum; duodenum; jejunum; ileum; colon), and (2) to calculate a ratio of muscularis and mucosal layer thickness to aortic diameter measured at the level of the celiac artery (Musc:Ao and Muc:Ao) in each GI segment in a sample of healthy cats. Ultrasonographic examination of the GI tract was performed, and measurements of the individual layers in each GI segment were obtained in 38 healthy cats without clinical evidence of disease. The muscularis layer was significantly thickest in the ileum, compared with other segments, and it was thicker than the submucosa in all segments except the colon. The mucosa was the thickest layer in all segments, and was thickest in the duodenum and ileum. Measurements of the submucosal and serosal layers were not significantly different between all segments. Musc:Ao and Muc:Ao in each segment were 0.12 and 0.25 (gastric fundus), 0.12 and 0.18 (gastric body), 0.11 and 0.16 (pyloric antrum), 0.08 and 0.27 (duodenum), 0.08 and 0.22 (jejunum), 0.14 and 0.25 (ileum), and 0.05 and 0.08 (colon), respectively. Musc:Ao and Muc:Ao are clinically relevant values that can be used to objectively identify thickening of the muscularis and mucosal layers in response to GI diseases.},
   keywords = {Aging
Animal Feed
Animals
Cats/*anatomy & histology
Conscious Sedation
Intestines/anatomy & histology/*diagnostic imaging
Ultrasonography},
   ISSN = {1098-612x},
   Accession Number = {23906704},
   DOI = {10.1177/1098612x13499013},
   year = {2014},
   type = {Ref–rence Type}
}

@article{
   author = {Wong, T. and Ko, H. H. and Chan, E. S.},
   title = {IgE-Mediated allergy to wheat in a child with celiac disease - a case report},
   journal = {Allergy Asthma Clin Immunol},
   volume = {10},
   number = {1},
   pages = {56},
   note = {Wong, Tiffany
Ko, Hin Hin
Chan, Edmond S
Journal Article
England
Allergy Asthma Clin Immunol. 2014 Nov 10;10(1):56. doi: 10.1186/1710-1492-10-56. eCollection 2014.},
   abstract = {INTRODUCTION: Celiac disease and immediate type hypersensitivity to wheat are immune responses with different pathogenic mechanisms. Both diseases are well known entities but their coexistence in the same patient is rarely reported. This is a unique case presentation of a patient with celiac disease who developed concomitant IgE-mediated wheat allergy and presented with immediate symptoms in two body systems. CASE PRESENTATION: We report the case of a girl with celiac disease who subsequently developed IgE-mediated hypersensitivity to wheat. The patient is a Caucasian female who was diagnosed with celiac disease at 18 months of age after presenting with recurrent vomiting and failure to thrive. Her anti-tTG antibody level was greater than 200 E.U. and biopsy results from endoscopy were consistent with celiac disease. Specific IgE antibody to wheat was negative at 2 years of age. Around seven years of age, she developed immediate symptoms of urticaria, cough and shortness of breath with accidental exposures to wheat. Specific IgE antibody testing was repeated and positive to wheat (42.5 kU/L), as well as rye (33.9 kU/L), barley (53.4 kU/L) and oat (11.3 kU/L). At 9 years of age, skin prick testing was positive to wheat, barley and rye but negative to oat. The patient has subsequently tolerated an open oral food challenge to oat. She continues to avoid wheat, rye and barley and carries an epinephrine autoinjector at all times. CONCLUSION: To our knowledge, this is the first report of a patient with celiac disease and concomitant IgE-mediated allergy to wheat presenting with immediate symptoms in two body systems. Although the pathophysiology of these diseases is different, this case demonstrates that they are not exclusive of one another. In patients who develop unexplained symptoms consistent with IgE-mediated allergy, an allergy assessment should be considered.},
   keywords = {Allergy
Celiac disease
Wheat},
   ISSN = {1710-1484 (Print)
1710-1484},
   Accession Number = {25788950},
   DOI = {10.1186/1710-1492-10-56},
   year = {2014},
   type = {Ref–rence Type}
}

@article{
   author = {Yuan, J. and Gao, J. and Li, X. and Liu, F. and Wijmenga, C. and Chen, H. and Gilissen, L. J.},
   title = {The tip of the "celiac iceberg" in China: a systematic review and meta-analysis},
   journal = {PLoS One},
   volume = {8},
   number = {12},
   pages = {e81151},
   note = {1932-6203
Yuan, Juanli
Gao, Jinyan
Li, Xin
Liu, Fahui
Wijmenga, Cisca
Chen, Hongbing
Gilissen, Luud J W J
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
United States
PLoS One. 2013 Dec 4;8(12):e81151. doi: 10.1371/journal.pone.0081151. eCollection 2013.},
   abstract = {OBJECTIVE: Until recently, celiac disease was considered to be rare in China. We aimed to estimate its true status. METHODS: By searching the MEDLINE database and four Chinese full-text databases (CNKI, CBM, VIP and WANFANG) (up to August 2012), as well as two HLA allele frequency net databases and the Chinese Statistics Yearbook databases, we systematically reviewed the literature on definite and suspected cases of celiac disease, the predisposing HLA allele frequencies, and on gluten exposure in China. Meta-analysis was performed by analyzing DQ2, DQ8 and DQB1*0201 gene frequencies and heterogeneity in populations from different geographic regions and ethnicities in China. RESULTS: At present, the number of reported celiac disease cases is extremely low in China. The frequencies of the HLA-DQ2.5 and HLA-DQ8 haplotypes were 3.4% (95% confidence interval 1.3-5.5%) and 2.1% (0.1-4.1%), respectively. HLA-DQ2 and HLA-DQ8 antigen frequencies were 18.4% (15.0-21.7%) and 8.0% (4.5-11.4%), respectively. The frequency of the DQB1*0201 allele was 10.5% (9.3-11.6%) and it was more common in the northern Chinese than in the southern Chinese populations. The chance of being exposed to gluten is rapidly increasing all over China nowadays. CONCLUSION: The data on HLA haplotyping, in conjunction with increasing wheat consumption, strongly suggests that the occurrence of celiac disease is more common in China than currently reported. Coordinated measures by the Chinese government, medical and agricultural research institutions, and food industries, would be justified to create more awareness about celiac disease and to prevent it becoming a medical and societal burden.},
   keywords = {Alleles
Celiac Disease/chemically induced/*genetics/immunology
China/epidemiology
Databases, Bibliographic
Gene Expression
Gene Frequency
Genetic Heterogeneity
Glutens
HLA-DQ Antigens/*genetics/immunology
HLA-DQ beta-Chains/*genetics/immunology
Haplotypes
Histocompatibility Testing
Humans
Incidence},
   ISSN = {1932-6203},
   Accession Number = {24324669},
   DOI = {10.1371/journal.pone.0081151},
   year = {2013},
   type = {Ref–rence Type}
}

@article{
   author = {Zaccone, D. and Lauriano, E. R. and Capillo, G. and Zuwala, K. and Budzik, K. A. and Kuciel, M. and Zaccone, G.},
   title = {Confocal imaging of autonomic preganglionic neurons in the spinal cord of the caecilian Typhlonectes natans (Amphibia: Gymnophiona)},
   journal = {Acta Histochem},
   volume = {116},
   number = {8},
   pages = {1399-406},
   note = {1618-0372
Zaccone, Daniele
Lauriano, Eugenia Rita
Capillo, Gioele
Zuwala, Krystyna
Budzik, Karolina Agata
Kuciel, Michal
Zaccone, Giacomo
Journal Article
Germany
Acta Histochem. 2014 Oct;116(8):1399-406. doi: 10.1016/j.acthis.2014.09.004. Epub 2014 Sep 27.},
   abstract = {Little is known about the spinal sympathetic organization in the caecilian amphibians. We examined for the first time the location of sympathetic preganglionic neurons (SPNs) in the spinal cord using a panel of specific markers expressed in SPNs. The SPNs of anuran amphibians form two cell columns segregated mainly in the lateral and medial marginal areas of the central gray matter. In the caecilian Typhlonectes natans immunoreactivity for galanin and ChAT is found in most laterally arranged neurons lying in spinal segments 2-7. They are encircled by TH- and nNOS-immunoreactive nerve fibers. These neurons might project specifically to a population of adrenergic sympathetic postganglionic neurons in paravertebral ganglia and/or non-adrenergic sympathetic postganglionic neurons in the celiac ganglia. However the segmental restriction and target specificity of the neurons of the species studied are not known. As mucous and granular glands in the dermis may represent one of the peripheral targets of the adrenergic ganglion cells and reflect the prominent preganglionic cell columns, an immunohistochemical study was done also on these glands. Retrograde-tracing studies are, however, needed to study the segmental localization of the preganglionic neurons and their projections to the postganglionic neurons in sympathetic ganglia.},
   keywords = {Amphibians/*metabolism
Animals
Ganglia, Sympathetic/cytology
Immunohistochemistry
Microscopy, Confocal/*methods
Neurons/*cytology
Spinal Cord/*cytology
Caecilian amphibians
Confocal microscopy
Sympathetic preganglionic neurons},
   ISSN = {0065-1281},
   Accession Number = {25265879},
   DOI = {10.1016/j.acthis.2014.09.004},
   year = {2014},
   type = {Ref–rence Type}
}

@article{
   author = {Zanini, B. and Petroboni, B. and Not, T. and Di Toro, N. and Villanacci, V. and Lanzarotto, F. and Pogna, N. and Ricci, C. and Lanzini, A.},
   title = {Search for atoxic cereals: a single blind, cross-over study on the safety of a single dose of Triticum monococcum, in patients with celiac disease},
   journal = {BMC Gastroenterol},
   volume = {13},
   pages = {92},
   note = {1471-230x
Zanini, Barbara
Petroboni, Beatrice
Not, Tarcisio
Di Toro, Nicola
Villanacci, Vincenzo
Lanzarotto, Francesco
Pogna, Norberto
Ricci, Chiara
Lanzini, Alberto
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
England
BMC Gastroenterol. 2013 May 24;13:92. doi: 10.1186/1471-230X-13-92.},
   abstract = {BACKGROUND: Cereals of baking quality with absent or reduced toxicity are actively sought as alternative therapy to a gluten-free diet (GFD) for patients with coeliac disease (CD). Triticum monococcum, an ancient wheat, is a potential candidate having no toxicity in in-vitro and ex-vivo studies. The aim of our study was to investigate on the safety of administration of a single dose of gluten of Tm in patients with CD on GFD. METHODS: We performed a single blind, cross-over study involving 12 CD patients who had been on a GFD for at least 12 months, challenged on day 0, 14 and 28 with a single fixed dose of 2.5 grams of the following (random order): Tm, rice (as reference atoxic protein) and Amygluten (as reference toxic protein) dispersed in a gluten-free pudding. The primary end-point of the study was the change in intestinal permeability, as assessed by changes in the urinary lactulose/rhamnose ratio (L/R ratio) measured by High Pressure Liquid Chromatography. We also assessed the occurrence of adverse gastrointestinal events, graded for intensity and duration according to the WHO scale. Variables were expressed as mean +/- SD; paired t-test and chi(2) test were used as appropriate. RESULTS: The urinary L/R ratio did not change significantly upon challenge with the 3 cereals, and was 0.055 +/- 0.026 for Tm Vs 0.058 +/- 0.035 for rice (p = 0.6736) and Vs 0.063 +/- 0.054 with Amygluten (p = 0.6071). Adverse gastrointestinal events were 8 for Tm, Vs 11 for rice (p = 0.6321) and Vs 31 for Amygluten p = 0.0016), and, in all cases events were graded as "mild" or "moderate" with TM and rice, and as "severe" or "disabling" in 4 cases during Amygluten. CONCLUSIONS: No definite conclusion can be drawn on the safety of Tm, based on no change in urinary L/R because even Amygluten, a toxic wheat protein, did not cause a significant change in urinary L/R indicating low sensitivity of this methodology in studies on acute toxicity. Tm was, however, well tolerated by all patients providing the rationale for further investigation on the safety of this cereal for CD patients. TRIAL REGISTRATION: EudraCT-AIFA n2008-000697-20.},
   keywords = {Celiac Disease/*diet therapy/metabolism
Cross-Over Studies
Diet, Gluten-Free
*Edible Grain/adverse effects
Glutens/administration & dosage
Humans
Intestinal Absorption
Lactulose/urine
Oryza
Plant Extracts/*administration & dosage/adverse effects
Rhamnose/urine
Single-Blind Method
*Triticum},
   ISSN = {1471-230x},
   Accession Number = {23706063},
   DOI = {10.1186/1471-230x-13-92},
   year = {2013},
   type = {Ref–rence Type}
}

@article{
   author = {Zannini, E.},
   title = {[Technological challenges and strategies for developing low-protein/protein-free cereal foods for the dietotherapic treatment]},
   journal = {G Ital Nefrol},
   volume = {31},
   number = {2},
   note = {1724-5990
Zannini, Emanuele
English Abstract
Journal Article
Italy
G Ital Nefrol. 2014 Mar-Apr;31(2). pii: gin/31.2.15.},
   abstract = {Western countries are finding health care costs to be a continuously increasing financial burden in excess of previous budgetary allocations. Medical nutrition therapies (MNT) have proven to be an efficient cost minimising tool whilst concurrently improving the patient's quality of life. These MNTs are defined as specially processed or formulated foods that are used for the dietary management of patients. Among the medical foods, low-protein/protein-free (LP/PF) foods have been shown to improve the physical manifestation of metabolic disorders in patients with amino acid or protein-related diseases, such as Phenylketonuria, Tyrosinaemia type I, as well as chronic kidney, and coeliac. Most of the cereal-based LP/PF foods currently marketed are a blend of refined or chemically-based food ingredients with unpalatable frequently artificial flavours, having excessive sweetness to mask the chemical taste of ingredients (drug-like approach). However, the adoption of an alternative to convention, such as a food-like approach to developing medical foods, it is a surprisingly complex process. This is specifically true when the technological aspects of LP/PF foods and, in particular, protein-free cereal foods are considered. The primary processing issues arise while trying to replace gluten in baked cereal products. This represents a significant technological challenge, since gluten is an essential structural network-building protein necessary for baked goods. In this article, the suitable food technology challenges and strategies for developing LP/PF cereal foods able to overcome the significant limitations of a food-like approach will be addressed.},
   keywords = {*Diet, Protein-Restricted
*Edible Grain
Food Industry/*methods
Humans
Kidney Diseases/*diet therapy},
   ISSN = {0393-5590},
   Accession Number = {24777928},
   year = {2014},
   type = {Ref–rence Type}
}

@article{
   author = {Zarkadas, M. and Dubois, S. and MacIsaac, K. and Cantin, I. and Rashid, M. and Roberts, K. C. and La Vieille, S. and Godefroy, S. and Pulido, O. M.},
   title = {Living with coeliac disease and a gluten-free diet: a Canadian perspective},
   journal = {J Hum Nutr Diet},
   volume = {26},
   number = {1},
   pages = {10-23},
   note = {1365-277x
Zarkadas, M
Dubois, S
MacIsaac, K
Cantin, I
Rashid, M
Roberts, K C
La Vieille, S
Godefroy, S
Pulido, O M
Journal Article
Research Support, Non-U.S. Gov't
England
J Hum Nutr Diet. 2013 Feb;26(1):10-23. doi: 10.1111/j.1365-277X.2012.01288.x. Epub 2012 Nov 15.},
   abstract = {OBJECTIVE: Strict adherence to a gluten-free diet is the only treatment for coeliac disease. The gluten-free diet is complex, costly and impacts on all activities involving food, making it difficult to maintain for a lifetime. The purpose of this cross-sectional study was to evaluate the difficulties experienced, the strategies used and the emotional impact of following a gluten-free diet among Canadians with coeliac disease. METHODS: A questionnaire was mailed to all members (n = 10 693) of both the Canadian Celiac Association and the Fondation quebecoise de la maladie coeliaque in 2008. RESULTS: The overall response rate was 72%. Results are presented for the 5912 respondents (>/=18 years) reporting biopsy-confirmed coeliac disease and/or dermatitis herpetiformis. Two-thirds never intentionally consumed gluten. Women reported significantly greater emotional responses to a gluten-free diet but, with time, were more accepting of it than men. Difficulties and negative emotions were experienced less frequently by those on the diet for >5 years, although food labelling and eating away from home remained very problematic. Frustration and isolation because of the diet were the most common negative emotions experienced. CONCLUSIONS: The present study quantifies the difficulties experienced, the strategies used and the emotional impact of following a gluten-free diet. It highlights the need to improve the training and education of dietitians, other health providers and the food service industry workers about coeliac disease and a gluten-free diet, with the aim of better helping individuals improve their adherence to a gluten-free diet and their quality of life.},
   keywords = {Adult
Aged
Canada
Celiac Disease/*diet therapy/psychology
Cross-Sectional Studies
Dermatitis Herpetiformis/diet therapy
Diet, Gluten-Free/*psychology
*Feeding Behavior
Female
Food Labeling
*Frustration
*Glutens/adverse effects
Humans
Male
Middle Aged
Patient Compliance/*psychology
Sex Factors
*Social Isolation
Surveys and Questionnaires},
   ISSN = {0952-3871},
   Accession Number = {23157646},
   DOI = {10.1111/j.1365-277X.2012.01288.x},
   year = {2013},
   type = {Ref–rence Type}
}

@article{
   author = {Zharkov, I. M. and Miroshnichenko, L. A. and Zviagin, A. A. and Bavykina, I. A.},
   title = {[Amaranth flour: characteristics, comparative analysis, application possibilities]},
   journal = {Vopr Pitan},
   volume = {83},
   number = {1},
   pages = {67-73},
   note = {Zharkov, I M
Miroshnichenko, L A
Zviagin, A A
Bavykina, I A
Comparative Study
English Abstract
Journal Article
Russia (Federation)
Vopr Pitan. 2014;83(1):67-73.},
   abstract = {Amaranth flour--a product of amaranth seeds processing--is a valuable industrial raw material that has an unique chemical composition and may be used for nutrition of people suffering from intolerance to traditional cereals protein, including celiac disease patients. The research aim was to study the composition of amaranth flour of two types compared with semolina which is traditionally used for nutrition by Russian population, as well as to compare the composition of milk amaranth flour porridge with milk semolina porridge. The composition of amaranth whole-ground flour and amaranth flour of premium grade processed from amaranth seeds grown in Voronezh region has been researched. It is to be noted that protein content in amaranth flour was 10.8-24.3% higher than in semolina, and its biological value and NPU-coefficient were higher by 22.65 and 46.51% respectively; lysine score in amaranth flour protein of premium grade came up to 107.54%, and in semolina protein only 40.95%. The level of digestible carbohydrates, including starch, was lower in amaranth flour than in semolina by 2.79-12.85 and 4.76-15.85% respectively, while fiber content was 15.5-30 fold higher. Fat content in amaranth flour of premium grade was 2,4 fold lower than in whole-ground amaranth flour but it was 45% higher than in semolina. The main advantage of amaranth flour protein compared to wheat protein is the predominance of albumins and globulins and a minimal content of prolamines and alpha-gliadin complete absence. The specifics of chemical composition allow the amaranth flour to be recommended for being included into nutrition of both healthy children and adults and also celiac disease patients.},
   keywords = {Adult
Amaranthus/*chemistry
Flour/*analysis
*Food Analysis
Humans
*Nutritive Value
Seeds/*chemistry},
   ISSN = {0042-8833 (Print)
0042-8833},
   Accession Number = {25059059},
   year = {2014},
   type = {Ref–rence Type}
}

@article{
   author = {Zhu, R. and Liu, Q. and Huang, W. and Yu, Y. and Wang, Y.},
   title = {Comparison of the replication characteristics of vaccinia virus strains Guang 9 and Tian Tan in vivo and in vitro},
   journal = {Arch Virol},
   volume = {159},
   number = {10},
   pages = {2587-96},
   note = {1432-8798
Zhu, Rong
Liu, Qiang
Huang, Weijin
Yu, Yongxin
Wang, Youchun
Journal Article
Research Support, Non-U.S. Gov't
Austria
Arch Virol. 2014 Oct;159(10):2587-96. doi: 10.1007/s00705-014-2079-2. Epub 2014 May 17.},
   abstract = {Vaccinia virus is widely used as a vector in the development of recombinant vaccines. Vaccinia virus strain Guang 9 (VG9), which was derived from vaccinia virus strain Tian Tan (VTT) by successive plaque-cloning purification, was more attenuated than VTT. In this study, the host cell range and the growth and replication of VG9 were compared with those of VTT. The results showed that both VG9 and VTT could infect permissive cells (Vero, TK-143 and CEF) and semipermissive cells PK (15) and induced a visible cytopathic effect (CPE). Both strains could infect nonpermissive CHO-K1 cells but neither was able to reproduce. The replicative ability of VG9 was a little lower than that of VTT. Additionally, recombinant vaccinia viruses containing a firefly luciferase gene (VG9-L and VTT-L) were constructed, and their expression in vitro and replication and spread in vivo were compared. The expression ability of VG9-L was lower than that of VTT-L. Whole-animal imaging data indicated that VG9-L could reproduce quickly and express the exogenous protein at the site of inoculation, regardless of whether the intramuscular, intracutaneous, subcutaneous or celiac inoculation route was used. VG9-L was better in its ability to express a foreign protein than VTT-L, but the time during which expression occurred was shorter. There was no dissemination of virus in mice inoculated with either strain. In summary, this study demonstrates the possibility of using VG9 for the production of smallpox vaccines or the construction of recombinant vaccinia virus vaccines.},
   keywords = {Animals
CHO Cells
Cell Line
Cercopithecus aethiops
Chick Embryo
Cricetulus
Female
Gene Expression
Gene Expression Regulation, Viral
HEK293 Cells
Humans
Mice
Mice, Inbred BALB C
Smallpox Vaccine/*immunology
Vaccines, Synthetic/immunology
Vaccinia virus/classification/genetics/*growth & development
Vero Cells
Virus Replication/genetics/*physiology},
   ISSN = {0304-8608},
   Accession Number = {24838849},
   DOI = {10.1007/s00705-014-2079-2},
   year = {2014},
   type = {Ref–rence Type}
}

@article{
   author = {Zorb, C. and Becker, D. and Hasler, M. and Muhling, K. H. and Godde, V. and Niehaus, K. and Geilfus, C. M.},
   title = {Silencing of the sulfur rich alpha-gliadin storage protein family in wheat grains (Triticum aestivum L.) causes no unintended side-effects on other metabolites},
   journal = {Front Plant Sci},
   volume = {4},
   pages = {369},
   note = {Zorb, Christian
Becker, Dirk
Hasler, Mario
Muhling, Karl H
Godde, Victoria
Niehaus, Karsten
Geilfus, Christoph-Martin
Journal Article
Switzerland
Front Plant Sci. 2013 Sep 17;4:369. doi: 10.3389/fpls.2013.00369. eCollection 2013.},
   abstract = {Wheat is an important source of proteins and metabolites for human and animal nutrition. To assess the nutritional quality of wheat products, various protein and diverse metabolites have to be evaluated. The grain storage protein family of the alpha-gliadins are suggested to be the primary initiator of the inflammatory response to gluten in Celiac disease patients. With the technique of RNAi, the alpha-gliadin storage protein fraction in wheat grains was recently knocked down. From a patient's perspective, this is a desired approach, however, this study aims to evaluate whether such a down-regulation of these problematic alpha-gliadins also has unintended side-effects on other plant metabolites. Such uncontrolled and unknown arbitrary effects on any metabolite in plants designated for food production would surely represent an avoidable risk for the consumer. In general, alpha-gliadins are rich in sulfur, making their synthesis and content depended of the sulfur supply. For this reason, the influence of the application of increasing sulfur amounts on the metabolome of alpha-gliadin-deficient wheat was additionally investigated because it might be possible that e.g., considerable high/low amounts of S might increase or even induce such unintended effects that are not observable under moderate S nutrition. By silencing the alpha-gliadin genes, a recently developed wheat line that lacks the set of 75 corresponding alpha-gliadin proteins has become available. The plants were subsequently tested for RNAi-induced effects on metabolites that were not directly attributable to the specific effects of the RNAi-approach on the alpha-gliadin proteins. For this, GC-MS-based metabolite profiles were recorded. A comparison of wild type with gliadin-deficient plants cultivated in pot experiments revealed no differences in all 109 analyzed metabolites, regardless of the S-nutritional status. No unintended effects attributable to the RNAi-based specific genetic deletion of a storage protein fraction were observed.},
   keywords = {Celiac disease
Gc-ms
gliadin
metabolites
sulfur
wheat},
   ISSN = {1664-462X (Print)
1664-462x},
   Accession Number = {24062763},
   DOI = {10.3389/fpls.2013.00369},
   year = {2013},
   type = {Ref–rence Type}
}

@article{
   author = {Zuccotti, G. and Fabiano, V. and Dilillo, D. and Picca, M. and Cravidi, C. and Brambilla, P.},
   title = {Intakes of nutrients in Italian children with celiac disease and the role of commercially available gluten-free products},
   journal = {J Hum Nutr Diet},
   volume = {26},
   number = {5},
   pages = {436-44},
   note = {1365-277x
Zuccotti, G
Fabiano, V
Dilillo, D
Picca, M
Cravidi, C
Brambilla, P
Journal Article
Research Support, Non-U.S. Gov't
England
J Hum Nutr Diet. 2013 Oct;26(5):436-44. doi: 10.1111/jhn.12026. Epub 2012 Dec 17.},
   abstract = {BACKGROUND: Celiac disease (CD) is a chronic gluten-sensitive enteropathy. Life-long gluten-free diet (GFD) is the only therapeutic option; however, it may contribute to the consumption of an unbalanced diet. The present study aimed to evaluate the dietary intake of CD affected children on a GFD and compare it with non-celiac children and with Italian nutritional intakes recommendations, as well as evaluate the contribution of commercially available gluten-free products (GFPs). METHODS: Eighteen celiac children, median age 7.6 years, median GFD duration 4.2 years, and 18 non-celiac controls, were enrolled in a cross-sectional age-matched study. Dietary intakes of both groups were collected using a food frequency questionnaire and a 24-hour dietary recall. Nutritional intakes were compared between the group and controls and with Italian dietary reference values. The contribution of GFPs to energy and macronutrient intakes was evaluated. RESULTS: Median energy intake was significantly higher in CD patients than in controls (8961.8 and 5761.0 kJ day(-1); P < 0.001). CD subjects showed higher carbohydrate intakes and lower fat intakes compared to controls. Protein-derived energy did not differ. By contrast to control subjects, energy derived from carbohydrate intakes in CD children met the Italian recommendations. Both children groups showed higher protein and fat intakes than recommended in Italy. GFPs consumption accounted for 36.3% of daily total energy intake. CONCLUSIONS: Intakes of simple sugars, fats and protein exceeded the National recommendations for health. Children with CD had significantly higher energy intakes than controls, although body mass index was comparable across the groups. Lack of nutritional information for GFPs prevented complete dietary analysis of subfractions of fat and micronutrient intakes. This aspect need to be addressed if studies in this field are to be meaningful in the future.},
   keywords = {Advertising as Topic
Body Mass Index
Celiac Disease/*diet therapy/*epidemiology
Child
Child, Preschool
Cross-Sectional Studies
Diet Records
*Diet, Gluten-Free
Dietary Carbohydrates/administration & dosage
Dietary Fats/administration & dosage
Dietary Proteins/administration & dosage
Dietary Supplements
Energy Intake
*Feeding Behavior
Female
Humans
Italy/epidemiology
Male
Micronutrients/administration & dosage
*Nutritional Status
celiac disease
children
gluten-free diet
gluten-free products
nutritional status},
   ISSN = {0952-3871},
   Accession Number = {23252793},
   DOI = {10.1111/jhn.12026},
   year = {2013},
   type = {Ref–rence Type}
}

@article{
   author = {Zupin, L. and Catamo, E. and Polesello, V. and Crovella, S. and Segat, L.},
   title = {Interleukin-18 gene promoter polymorphisms and celiac disease in Italian patients},
   journal = {Mol Biol Rep},
   volume = {42},
   number = {2},
   pages = {525-33},
   note = {1573-4978
Zupin, Luisa
Catamo, Eulalia
Polesello, Vania
Crovella, Sergio
Segat, Ludovica
Journal Article
Research Support, Non-U.S. Gov't
Netherlands
Mol Biol Rep. 2015 Feb;42(2):525-33. doi: 10.1007/s11033-014-3796-z. Epub 2014 Nov 6.},
   abstract = {Celiac disease (CD) is the most common food-sensitive enteropathy in genetically susceptible individuals. The major genetic risk factors known are specific human leukocyte antigen (HLA)-DQ haplotypes, but other genetic factors are supposed to be involved. Interleukin-18 (IL-18) is a pro-inflammatory cytokine that has an important role in the immune defense and it has the potential to influence inflammatory disorders. IL-18 is able to promote Th1 cell development and it is expressed in the mucosa of the small intestine in celiac patients. Given the IL-18 biological role, and since a few studies have previously suggested its involvement in CD, in order to investigate the role of IL18 gene in the susceptibility to CD we have performed a case-control study, analyzing two IL18 gene promoter polymorphisms, previously reported to impair the transcriptional activity of the gene, (-137G > C and -607C > A, rs187238 and rs1946518 respectively). A total of 556 CD Italian patients and 582 controls, further stratified for HLA class II (DQ) CD risk haplotypes were enrolled. The -607A > C A allele and A/A genotype, as well as the combination of this allele with the -137G allele in the AG haplotype, were associated with an increased risk towards CD development, in particular in HLA-DQ2.2 patients. Although the association was very moderate, our results indicate the possible involvement of IL18 gene in the susceptibility to CD, and for this reason we do think it should deserve further investigation.},
   keywords = {Alleles
Case-Control Studies
Celiac Disease/*epidemiology/*genetics
European Continental Ancestry Group
Female
Gene Frequency
Genetic Association Studies
*Genetic Predisposition to Disease
Genotype
HLA Antigens/genetics
Haplotypes
Humans
Interleukin-18/*genetics
Italy/epidemiology
Male
Odds Ratio
*Polymorphism, Single Nucleotide
*Promoter Regions, Genetic},
   ISSN = {0301-4851},
   Accession Number = {25374428},
   DOI = {10.1007/s11033-014-3796-z},
   year = {2015},
   type = {Ref–rence Type}
}

license: MIT

license_type: permissive

branch_name: refs/heads/master

extension: bib


text:
@article{Kanchi2014,
author = {Kanchi, Krishna L. and Johnson, Kimberly J. and Lu, Charles and McLellan, Michael D. and Leiserson, Mark D. M. and Wendl, Michael C. and Zhang, Qunyuan and Koboldt, Daniel C. and Xie, Mingchao and Kandoth, Cyriac and McMichael, Joshua F. and Wyczalkowski, Matthew a. and Larson, David E. and Schmidt, Heather K. and Miller, Christopher a. and Fulton, Robert S. and Spellman, Paul T. and Mardis, Elaine R. and Druley, Todd E. and Graubert, Timothy a. and Goodfellow, Paul J. and Raphael, Benjamin J. and Wilson, Richard K. and Ding, Li},
doi = {10.1038/ncomms4156},
issn = {2041-1723},
journal = {Nature Communications},
month = jan,
pages = {1--14},
publisher = {Nature Publishing Group},
title = {{Integrated analysis of germline and somatic variants in ovarian cancer}},
url = {http://www.nature.com/doifinder/10.1038/ncomms4156},
volume = {5},
year = {2014}
}

repository: mdml/mdml-website

repo_name: mdml/mdml-website

gha_license_id: MIT

gha_language: CSS


text:
DESCRIPTION = "PETALINUX image definition for Xilinx boards"
LICENSE = "MIT"

require recipes-core/images/petalinux-image-common.inc

inherit extrausers
COMMON_FEATURES = "\
		ssh-server-dropbear \
		hwcodecs \
		"
IMAGE_LINGUAS = " "

IMAGE_INSTALL = "\
		kernel-modules \
		mtd-utils \
		canutils \
		openssh-sftp-server \
		pciutils \
		run-postinsts \
		opencv \
		udev-extraconf \
		gstreamer1.0-plugins-bad \
		gstreamer1.0-plugins-base \
		gstreamer1.0-plugins-good \
		kernel-module-hdmi \
		packagegroup-core-boot \
		packagegroup-core-ssh-dropbear \
		tcf-agent \
		gstreamer1.0 \
		gstreamer1.0-omx \
		bridge-utils \
		hellopm \
		libdrm \
		libdrm-tests \
		libdrm-kms \
		packagegroup-petalinux-opencv \
		ev-vcu-plt \
		gst-sdx \
		gstreamer-vcu-examples \
		xrt-dev \
		xrt \
		zocl \
		mnt-sd \
		opencl-headers-dev \
		opencl-clhpp-dev \
		opencl-clhpp-dev \
		opencl-headers-dev \
		rtsp-app \
		xrt \
		xrt-dev \
		zocl \
		"
EXTRA_USERS_PARAMS = "usermod -P root root;"

extension: bb