text:
and Almquist, Joachim and Ahlstr{\"o}m, Christine
             and Gabrielsson, Johan and Jirstrand, Mats",
  journal = "AAPS J.",
  volume  =  17,
  number  =  3,
  pages   = "586--596",
  month   =  may,
  year    =  2015
}

@ARTICLE{Albert2011-fg,
  title   = "The diagnosis of mild cognitive impairment due to Alzheimer's
             disease: recommendations from the National Institute on
             {Aging-Alzheimer's} Association workgroups on diagnostic
             guidelines for Alzheimer's disease",
  author  = "Albert, Marilyn S and DeKosky, Steven T and Dickson, Dennis and
             Dubois, Bruno and Feldman, Howard H and Fox, Nick C and Gamst,
             Anthony and Holtzman, David M and Jagust, William J and Petersen,
             Ronald C and Snyder, Peter J and Carrillo, Maria C and Thies, Bill
             and Phelps, Creighton H",
  journal = "Alzheimers. Dement.",
  volume  =  7,
  number  =  3,
  pages   = "270--279",
  month   =  may,
  year    =  2011
}

@ARTICLE{Sano2011-yl,
  title   = "Adding delayed recall to the Alzheimer Disease Assessment Scale is
             useful in studies of mild cognitive impairment but not Alzheimer
             disease",
  author  = "Sano, Mary and Raman, Rema and Emond, Jennifer and Thomas, Ronald
             G and Petersen, Ronald and Schneider, Lon S and Aisen, Paul S",
  journal = "Alzheimer Dis. Assoc. Disord.",
  volume  =  25,
  number  =  2,
  pages   = "122--127",
  year    =  2011
}

@ARTICLE{Seeman2015-bn,
  title    = "Co-administration of Antiresorptive and Anabolic Agents: A Missed
              Opportunity",
  author   = "Seeman, Ego and Martin, T John",
  journal  = "J. Bone Miner. Res.",
  volume   =  30,
  number   =  5,
  pages    = "753--764",
  month    =  may,
  year     =  2015,
  keywords = "ANABOLIC THERAPY; ANTIRESORPTIVE THERAPY; BONE MINERAL DENSITY;
              MICROARCHITECTURE; OSTEOPOROSIS; REMODELING"
}

@ARTICLE{Post2013-qx,
  title   = "Application of a mechanism-based disease systems model for
             osteoporosis to clinical data",
  author  = "Post, Teun M and Schmidt, Stephan and Peletier, Lambertus A and de
             Greef, Rik and Kerbusch, Thomas and Danhof, Meindert",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  40,
  number  =  2,
  pages   = "143--156",
  month   =  apr,
  year    =  2013
}

@BOOK{Gabrielsson2007-as,
  title     = "Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and
               Applications, Fourth Edition",
  author    = "Gabrielsson, J and Weiner, D",
  publisher = "Taylor \& Francis",
  year      =  2007
}

@ARTICLE{LoRusso2011-xp,
  title   = "Trastuzumab emtansine: a unique antibody-drug conjugate in
             development for human epidermal growth factor receptor 2-positive
             cancer",
  author  = "LoRusso, Patricia M and Weiss, Denise and Guardino, Ellie and
             Girish, Sandhya and Sliwkowski, Mark X",
  journal = "Clin. Cancer Res.",
  volume  =  17,
  number  =  20,
  pages   = "6437--6447",
  month   =  oct,
  year    =  2011
}

@ARTICLE{Hyndman1996-mw,
  title    = "{Sample quantiles in statistical packages}",
  author   = "Hyndman, Rob J and Fan, Yanan",
  journal  = "Am. Stat.",
  volume   =  50,
  pages    = "361--365",
  year     =  1996,
  keywords = "estimate master quartile r"
}

@MANUAL{R_Core_Team2014-nj,
  title        = "R: A Language and Environment for Statistical Computing",
  author       = "{R Core Team}",
  year         =  2014,
  address      = "Vienna, Austria",
  organization = "R Foundation for Statistical Computing"
}

@ARTICLE{Stuart2010-qr,
  title   = "Matching methods for causal inference: A review and a look forward",
  author  = "Stuart, Elizabeth A",
  journal = "Stat. Sci.",
  volume  =  25,
  number  =  1,
  pages   = "1--21",
  month   =  feb,
  year    =  2010
}

@ARTICLE{Austin2011-mv,
  title   = "An Introduction to Propensity Score Methods for Reducing the
             Effects of Confounding in Observational Studies",
  author  = "Austin, Peter C",
  journal = "Multivariate Behav. Res.",
  volume  =  46,
  number  =  3,
  pages   = "399--424",
  month   =  may,
  year    =  2011
}

@ARTICLE{Nony2014-wx,
  title   = "A methodological framework for drug development in rare diseases",
  author  = "Nony, Patrice and Kurbatova, Polina and Bajard, Agathe and Malik,
             Salma and Castellan, Charlotte and Chabaud, Sylvie and Volpert,
             Vitaly and Eymard, Nathalie and Kassai, Behrouz and Cornu,
             Catherine and {CRESim} and {Epi-CRESim}",
  journal = "Orphanet J. Rare Dis.",
  volume  =  9,
  pages   = "164",
  year    =  2014
}

@ARTICLE{Powell2007-kn,
  title   = "Pharmacometrics at {FDA}: evolution and impact on decisions",
  author  = "Powell, J R and Gobburu, J V S",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  82,
  number  =  1,
  pages   = "97--102",
  month   =  jul,
  year    =  2007
}

@ARTICLE{Bhattaram2007-yi,
  title   = "Impact of pharmacometric reviews on new drug approval and labeling
             decisions--a survey of 31 new drug applications submitted between
             2005 and 2006",
  author  = "Bhattaram, V A and Bonapace, C and Chilukuri, D M and Duan, J Z
             and Garnett, C and Gobburu, J V S and Jang, S H and Kenna, L and
             Lesko, L J and Madabushi, R and Men, Y and Powell, J R and Qiu, W
             and Ramchandani, R P and Tornoe, C W and Wang, Y and Zheng, J J",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  81,
  number  =  2,
  pages   = "213--221",
  month   =  feb,
  year    =  2007
}

@ARTICLE{Romero2014-wu,
  title   = "Modeling and simulation for medical product development and
             evaluation: highlights from the {FDA-C-Path-ISOP} 2013 workshop",
  author  = "Romero, Klaus and Sinha, Vikram and Allerheiligen, Sandra and
             Danhof, Meindert and Pinheiro, Jose and Kruhlak, Naomi and Wang,
             Yaning and Wang, Sue-Jane and Sauer, John-Michael and Marier, J F
             and Corrigan, Brian and Rogers, James and Lambers Heerspink, H J
             and Gumbo, Tawanda and Vis, Peter and Watkins, Paul and Morrison,
             Tina and Gillespie, William and Gordon, Mark Forrest and
             Stephenson, Diane and Hanna, Debra and Pfister, Marc and Lalonde,
             Richard and Colatsky, Thomas",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  41,
  number  =  6,
  pages   = "545--552",
  month   =  dec,
  year    =  2014
}

@ARTICLE{Gobburu2002-pp,
  title   = "Application of modeling and simulation to integrate clinical
             pharmacology knowledge across a new drug application",
  author  = "Gobburu, J V S and Sekar, V J",
  journal = "Int. J. Clin. Pharmacol. Ther.",
  volume  =  40,
  number  =  7,
  pages   = "281--288",
  month   =  jul,
  year    =  2002
}

@ARTICLE{Williamson2012-ea,
  title   = "Propensity scores: from naive enthusiasm to intuitive
             understanding",
  author  = "Williamson, Elizabeth and Morley, Ruth and Lucas, Alan and
             Carpenter, James",
  journal = "Stat. Methods Med. Res.",
  volume  =  21,
  number  =  3,
  pages   = "273--293",
  month   =  jun,
  year    =  2012
}

@TECHREPORT{Dirks2010-uf,
  title       = "Population {PharmacokineticModeling} and Exploratory
                 {Exposure-Response} Analysis of Hydromorphone in Pediatric
                 Patients",
  author      = "Dirks, Nathanael L",
  institution = "Purdue Pharma L.P.",
  year        =  2010
}

@ARTICLE{Zhang2013-fs,
  title    = "A Phase {I} Bayesian Adaptive Design to Simultaneously Optimize
              Dose and Schedule Assignments Both Between and Within Patients",
  author   = "Zhang, Jin and Braun, Thomas M",
  journal  = "J. Am. Stat. Assoc.",
  volume   =  108,
  number   =  503,
  month    =  jan,
  year     =  2013,
  keywords = "Bayesian statistics; Clinical trial; Dose-escalation study;
              Dynamic treatment regime; Non-mixture cure model"
}

@ARTICLE{Lai2009-sm,
  title   = "Multilevel mixture cure models with random effects",
  author  = "Lai, Xin and Yau, Kelvin K W",
  journal = "Biom. J.",
  volume  =  51,
  number  =  3,
  pages   = "456--466",
  month   =  jun,
  year    =  2009
}

@ARTICLE{Ho2007-cy,
  title   = "Matching as Nonparametric Preprocessing for Reducing Model
             Dependence in Parametric Causal Inference",
  author  = "Ho, Daniel and Imai, Kosuke and King, Gary and Stuart, Elizabeth",
  journal = "Polit. Anal.",
  volume  =  15,
  number  =  3,
  pages   = "199--236",
  year    =  2007
}

@ARTICLE{Ho2007-gm,
  title   = "Matchit: Nonparametric Preprocessing for Parametric Causal
             Inference",
  author  = "Ho, Daniel and Imai, Kosuke and King, Gary and Stuart, Elizabeth",
  journal = "J. Stat. Softw.",
  year    =  2007
}

@ARTICLE{De_Castro2010-xt,
  title   = "A note on a unified approach for cure rate models",
  author  = "de Castro, Mario and Cancho, Vicente G and Rodrigues, Josemar",
  journal = "Braz. J. Probab. Stat.",
  volume  =  24,
  number  =  1,
  month   =  mar,
  year    =  2010
}

@ARTICLE{Yin2005-wv,
  title     = "Cure rate models: A unified approach",
  author    = "Yin, Guosheng and Ibrahim, Joseph G",
  journal   = "Can. J. Stat.",
  publisher = "Wiley-Blackwell",
  volume    =  33,
  number    =  4,
  pages     = "559--570",
  year      =  2005,
  keywords  = "Bayesian inference, Box-Cox transformation, cure fraction, Gibbs
               sampling, mixture cure model, promotion time cure model"
}

@ARTICLE{Ordas2012-ji,
  title   = "{Anti-TNF} monoclonal antibodies in inflammatory bowel disease:
             pharmacokinetics-based dosing paradigms",
  author  = "Ord{\'a}s, Ingrid and Mould, Diane R and Feagan, Brian G and
             Sandborn, William J",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  91,
  number  =  4,
  pages   = "635--646",
  month   =  apr,
  year    =  2012
}

@ARTICLE{Ordas2012-zk,
  title   = "Therapeutic drug monitoring of tumor necrosis factor antagonists
             in inflammatory bowel disease",
  author  = "Ord{\'a}s, Ingrid and Feagan, Brian G and Sandborn, William J",
  journal = "Clin. Gastroenterol. Hepatol.",
  volume  =  10,
  number  =  10,
  pages   = "1079--87; quiz e85--6",
  month   =  oct,
  year    =  2012
}

@ARTICLE{Guerra2011-fc,
  title   = "Utility of measuring serum concentrations of {anti-TNF} agents and
             anti-drug antibodies in inflammatory bowel disease",
  author  = "Guerra, Iv{\'a}n and Chaparro, Mar{\'\i}a and Bermejo, Fernando
             and Gisbert, Javier P",
  journal = "Curr. Drug Metab.",
  volume  =  12,
  number  =  6,
  pages   = "594--598",
  month   =  jul,
  year    =  2011
}

@ARTICLE{Bendtzen2009-xk,
  title   = "Individual medicine in inflammatory bowel disease: monitoring
             bioavailability, pharmacokinetics and immunogenicity of
             anti-tumour necrosis factor-alpha antibodies",
  author  = "Bendtzen, Klaus and Ainsworth, Mark and Steenholdt, Casper and
             Thomsen, Ole {\O}stergaard and Brynskov, J{\o}rn",
  journal = "Scand. J. Gastroenterol.",
  volume  =  44,
  number  =  7,
  pages   = "774--781",
  year    =  2009
}

@ARTICLE{Magro2010-kr,
  title   = "Management of inflammatory bowel disease with infliximab and other
             anti-tumor necrosis factor alpha therapies",
  author  = "Magro, Fernando and Portela, Francisco",
  journal = "BioDrugs",
  volume  = "24 Suppl 1",
  pages   = "3--14",
  month   =  dec,
  year    =  2010
}

@ARTICLE{Huang2015-jd,
  title   = "Knowledge of Fecal Calprotectin and Infliximab Trough Levels
             Alters Clinical Decision-making for {IBD} Outpatients on
             Maintenance Infliximab Therapy",
  author  = "Huang, Vivian W and Prosser, Connie and Kroeker, Karen I and Wang,
             Haili and Shalapay, Carol and Dhami, Neil and Fedorak, Darryl K
             and Halloran, Brendan and Dieleman, Levinus A and Goodman, Karen J
             and Fedorak, Richard N",
  journal = "Inflamm. Bowel Dis.",
  volume  =  21,
  number  =  6,
  pages   = "1359--1367",
  month   =  jun,
  year    =  2015
}

@ARTICLE{Felice2015-gk,
  title    = "Therapeutic drug monitoring of {anti-TNF-$\alpha$} agents in
              inflammatory bowel diseases",
  author   = "Felice, Carla and Marzo, Manuela and Pugliese, Daniela and Papa,
              Alfredo and Rapaccini, Gian Lodovico and Guidi, Luisa and
              Armuzzi, Alessandro",
  journal  = "Expert Opin. Biol. Ther.",
  pages    = "1--11",
  month    =  may,
  year     =  2015,
  keywords = "anti-TNF; anti-drug antibody; inflammatory bowel disease;
              therapeutic drug monitoring; trough level"
}

@ARTICLE{Yarur2015-gf,
  title   = "Therapeutic Drug Monitoring of Anti-tumor Necrosis Factor Agents
             in Patients with Inflammatory Bowel Diseases",
  author  = "Yarur, Andres J and Rubin, David T",
  journal = "Inflamm. Bowel Dis.",
  month   =  apr,
  year    =  2015
}

@ARTICLE{Vaughn2015-ry,
  title   = "Biologic concentration testing in inflammatory bowel disease",
  author  = "Vaughn, Byron P and Sandborn, William J and Cheifetz, Adam S",
  journal = "Inflamm. Bowel Dis.",
  volume  =  21,
  number  =  6,
  pages   = "1435--1442",
  month   =  jun,
  year    =  2015
}

@ARTICLE{Insel2015-bn,
  title   = "Biomarkers and cognitive endpoints to optimize trials in
             Alzheimer's disease",
  author  = "Insel, Philip S and Mattsson, Niklas and Mackin, R Scott and
             Kornak, John and Nosheny, Rachel and Tosun-Turgut, Duygu and
             Donohue, Michael C and Aisen, Paul S and Weiner, Michael W and
             {Alzheimer's Disease Neuroimaging Initiative}",
  journal = "Ann Clin Transl Neurol",
  volume  =  2,
  number  =  5,
  pages   = "534--547",
  month   =  may,
  year    =  2015
}

@ARTICLE{Little2000-kk,
  title   = "Causal effects in clinical and epidemiological studies via
             potential outcomes: concepts and analytical approaches",
  author  = "Little, R J and Rubin, D B",
  journal = "Annu. Rev. Public Health",
  volume  =  21,
  pages   = "121--145",
  year    =  2000
}

@ARTICLE{Stuart2013-hk,
  title    = "Prognostic score-based balance measures can be a useful
              diagnostic for propensity score methods in comparative
              effectiveness research",
  author   = "Stuart, Elizabeth A and Lee, Brian K and Leacy, Finbarr P",
  journal  = "J. Clin. Epidemiol.",
  volume   =  66,
  number   = "8 Suppl",
  pages    = "S84--S90.e1",
  month    =  aug,
  year     =  2013,
  keywords = "Causal inference; Confounding; Disease risk score; Matching
              methods; Nonexperimental study; Propensity score diagnostics"
}

@ARTICLE{Rosenbaum1983-qt,
  title     = "The Central Role of the Propensity Score in Observational
               Studies for Causal Effects",
  author    = "Rosenbaum, Paul R and Rubin, Donald B",
  journal   = "Biometrika",
  publisher = "Biometrika Trust",
  volume    =  70,
  number    =  1,
  pages     = "41--55",
  month     =  apr,
  year      =  1983,
  copyright = "Copyright \copyright{} 1983 Biometrika Trust",
  language  = "English"
}

@ARTICLE{Bang2005-ew,
  title   = "Doubly robust estimation in missing data and causal inference
             models",
  author  = "Bang, Heejung and Robins, James M",
  journal = "Biometrics",
  volume  =  61,
  number  =  4,
  pages   = "962--973",
  month   =  dec,
  year    =  2005
}

@ARTICLE{Zhao2004-xu,
  title     = "Using Matching to Estimate Treatment Effects: Data Requirements,
               Matching Metrics, and Monte Carlo Evidence",
  author    = "Zhao, Zhong",
  journal   = "Rev. Econ. Stat.",
  publisher = "MIT Press",
  volume    =  86,
  number    =  1,
  pages     = "91--107",
  year      =  2004
}

@ARTICLE{Rubin1979-mf,
  title     = "Using Multivariate Matched Sampling and Regression Adjustment to
               Control Bias in Observational Studies",
  author    = "Rubin, Donald B",
  journal   = "J. Am. Stat. Assoc.",
  publisher = "Taylor \& Francis, Ltd. on behalf of the American Statistical
               Association",
  volume    =  74,
  number    =  366,
  pages     = "318--328",
  month     =  jun,
  year      =  1979
}

@TECHREPORT{noauthor_2012-cf,
  title       = "Exposure-response analysis of trastuzumab emtansine ({T-DM1})
                 in patients with {HER2-positive} metastatic breast cancer",
  institution = "Genentech Report 12-0490",
  year        =  2012
}

@TECHREPORT{noauthor_2012-et,
  title       = "{BLA} 125427, Trastuzumab emtansine ({T-DM1}) Clinical
                 Pharmacology Review",
  institution = "Center for Drug Evaluation and Research",
  year        =  2012
}

@ARTICLE{Khurana2015-np,
  title    = "Canagliflozin use in patients with renal impairment-Utility of
              quantitative clinical pharmacology analyses in dose optimization",
  author   = "Khurana, Manoj and Vaidyanathan, Jayabharathi and Marathe, Anshu
              and Mehrotra, Nitin and Sahajwalla, Chandrahas G and Zineh, Issam
              and Jain, Lokesh",
  journal  = "J. Clin. Pharmacol.",
  volume   =  55,
  number   =  6,
  pages    = "647--656",
  month    =  jun,
  year     =  2015,
  keywords = "SGLT2; canagliflozin; diabetes; regulatory; renal impairment"
}

@ARTICLE{Gould2015-ps,
  title    = "Joint modeling of survival and longitudinal non-survival data:
              current methods and issues. Report of the {DIA} Bayesian joint
              modeling working group",
  author   = "Gould, A Lawrence and Boye, Mark Ernest and Crowther, Michael J
              and Ibrahim, Joseph G and Quartey, George and Micallef, Sandrine
              and Bois, Frederic Y",
  journal  = "Stat. Med.",
  volume   =  34,
  number   =  14,
  pages    = "2181--2195",
  month    =  jun,
  year     =  2015,
  keywords = "applications; random effects; software; time-dependent"
}

@ARTICLE{Rizopoulos2015-rz,
  title   = "Comments on 'Joint modeling of survival and longitudinal
             non-survival data: current methods and issues. Report of the {DIA}
             Bayesian Joint Modeling Working Group'",
  author  = "Rizopoulos, Dimitris",
  journal = "Stat. Med.",
  volume  =  34,
  number  =  14,
  pages   = "2196--2197",
  month   =  jun,
  year    =  2015
}

@ARTICLE{Farcomeni2015-nh,
  title   = "Discussion on 'Joint modeling of survival and longitudinal
             non-survival data' by Gould et al",
  author  = "Farcomeni, Alessio and Pareek, Bhuvanesh and Ghosh, Pulak",
  journal = "Stat. Med.",
  volume  =  34,
  number  =  14,
  pages   = "2198--2199",
  month   =  jun,
  year    =  2015
}

@ARTICLE{Price2015-ax,
  title   = "Commentary on 'Joint modeling of survival and longitudinal
             non-survival data: current methods and issues'",
  author  = "Price, Dionne L and Wang, Yan",
  journal = "Stat. Med.",
  volume  =  34,
  number  =  14,
  pages   = "2200--2201",
  month   =  jun,
  year    =  2015
}

@ARTICLE{Gould2015-ni,
  title   = "Responses to discussants of 'Joint modeling of survival and
             longitudinal non-survival data: current methods and issues. report
             of the {DIA} Bayesian joint modeling working group'",
  author  = "Gould, A Lawrence and Boye, Mark Ernest and Crowther, Michael J
             and Ibrahim, Joseph G and Quartey, George and Micallef, Sandrine
             and Bois, Frederic Y",
  journal = "Stat. Med.",
  volume  =  34,
  number  =  14,
  pages   = "2202--2203",
  month   =  jun,
  year    =  2015
}

@ARTICLE{Qiu2015-cf,
  title    = "Surveillance of cardiovascular diseases using a multivariate
              dynamic screening system",
  author   = "Qiu, Peihua and Xiang, Dongdong",
  journal  = "Stat. Med.",
  volume   =  34,
  number   =  14,
  pages    = "2204--2221",
  month    =  jun,
  year     =  2015,
  keywords = "LASSO; dynamic screening; multivariate longitudinal data; process
              monitoring; process screening; standardization; unequal sampling
              intervals"
}

@ARTICLE{Li2015-uf,
  title    = "The impact of companion diagnostic device measurement performance
              on clinical validation of personalized medicine",
  author   = "Li, Meijuan and Yu, Tinghui and Hu, Yun-Fu",
  journal  = "Stat. Med.",
  volume   =  34,
  number   =  14,
  pages    = "2222--2234",
  month    =  jun,
  year     =  2015,
  keywords = "analytical accuracy; biomarker; clinical validation trial;
              companion diagnostic device; imprecision; positive and negative
              percentage agreements; positive and negative predictive values"
}

@ARTICLE{Wan2015-vm,
  title    = "Bias in estimating the causal hazard ratio when using two-stage
              instrumental variable methods",
  author   = "Wan, Fei and Small, Dylan and Bekelman, Justin E and Mitra,
              Nandita",
  journal  = "Stat. Med.",
  volume   =  34,
  number   =  14,
  pages    = "2235--2265",
  month    =  jun,
  year     =  2015,
  keywords = "bias; instrumental variable; survival; two-stage predictor
              substitution; two-stage residual inclusion; unmeasured
              confounding"
}

@ARTICLE{Sattar2015-ha,
  title    = "Frailty models for pneumonia to death with a left-censored
              covariate",
  author   = "Sattar, Abdus and Sinha, Sanjoy K and Wang, Xiao-Feng and Li,
              Yehua",
  journal  = "Stat. Med.",
  volume   =  34,
  number   =  14,
  pages    = "2266--2280",
  month    =  jun,
  year     =  2015,
  keywords = "censored covariate; frailty models; likelihood method; limit of
              detection; nonparametric smoothing"
}

@ARTICLE{Mazzone2011-wa,
  title   = "Functional changes in Duchenne muscular dystrophy: a 12-month
             longitudinal cohort study",
  author  = "Mazzone, E and Vasco, G and Sormani, M P and Torrente, Y and
             Berardinelli, A and Messina, S and D'Amico, A and Doglio, L and
             Politano, L and Cavallaro, F and Frosini, S and Bello, L and
             Bonfiglio, S and Zucchini, E and De Sanctis, R and Scutifero, M
             and Bianco, F and Rossi, F and Motta, M C and Sacco, A and Donati,
             M A and Mongini, T and Pini, A and Battini, R and Pegoraro, E and
             Pane, M and Gasperini, S and Previtali, S and Napolitano, S and
             Martinelli, D and Bruno, C and Vita, G and Comi, G and Bertini, E
             and Mercuri, E",
  journal = "Neurology",
  volume  =  77,
  number  =  3,
  pages   = "250--256",
  month   =  jul,
  year    =  2011
}

@ARTICLE{Pane2014-zp,
  title   = "The 6 minute walk test and performance of upper limb in ambulant
             duchenne muscular dystrophy boys",
  author  = "Pane, Marika and Mazzone, Elena Stacy and Sivo, Serena and
             Fanelli, Lavinia and De Sanctis, Roberto and D'Amico, Adele and
             Messina, Sonia and Battini, Roberta and Bianco, Flaviana and
             Scutifero, Marianna and Petillo, Roberta and Frosini, Silvia and
             Scalise, Roberta and Vita, Gian Luca and Bruno, Claudio and
             Pedemonte, Marina and Mongini, Tiziana and Pegoraro, Elena and
             Brustia, Francesca and Gardani, Alice and Berardinelli, Angela and
             Lanzillotta, Valentina and Viggiano, Emanuela and Cavallaro,
             Filippo and Sframeli, Maria and Bello, Luca and Barp, Andrea and
             Busato, Fabio and Bonfiglio, Serena and Rolle, Enrica and Colia,
             Giulia and Bonetti, Annamaria and Palermo, Concetta and Graziano,
             Alessandra and D'Angelo, Grazia and Pini, Antonella and Corlatti,
             Alice and Gorni, Ksenija and Baranello, Giovanni and Antonaci,
             Laura and Bertini, Enrico and Politano, Luisa and Mercuri, Eugenio",
  journal = "PLoS Curr.",
  volume  =  6,
  year    =  2014
}

@ARTICLE{Pane2014-qe,
  title   = "Long term natural history data in ambulant boys with Duchenne
             muscular dystrophy: 36-month changes",
  author  = "Pane, Marika and Mazzone, Elena Stacy and Sivo, Serena and
             Sormani, Maria Pia and Messina, Sonia and D Amico, Adele and
             Carlesi, Adelina and Vita, Gianluca and Fanelli, Lavinia and
             Berardinelli, Angela and Torrente, Yvan and Lanzillotta, Valentina
             and Viggiano, Emanuela and D Ambrosio, Paola and Cavallaro,
             Filippo and Frosini, Silvia and Barp, Andrea and Bonfiglio, Serena
             and Scalise, Roberta and De Sanctis, Roberto and Rolle, Enrica and
             Graziano, Alessandra and Magri, Francesca and Palermo, Concetta
             and Rossi, Francesca and Donati, Maria Alice and Sacchini, Michele
             and Arnoldi, Maria Teresa and Baranello, Giovanni and Mongini,
             Tiziana and Pini, Antonella and Battini, Roberta and Pegoraro,
             Elena and Previtali, Stefano and Bruno, Claudio and Politano,
             Luisa and Comi, Giacomo P and Bertini, Enrico and Mercuri, Eugenio",
  journal = "PLoS One",
  volume  =  9,
  number  =  10,
  pages   = "e108205",
  year    =  2014
}

@ARTICLE{Bushby2014-zx,
  title    = "Ataluren treatment of patients with nonsense mutation
              dystrophinopathy",
  author   = "Bushby, Katharine and Finkel, Richard and Wong, Brenda and
              Barohn, Richard and Campbell, Craig and Comi, Giacomo P and
              Connolly, Anne M and Day, John W and Flanigan, Kevin M and
              Goemans, Nathalie and Jones, Kristi J and Mercuri, Eugenio and
              Quinlivan, Ros and Renfroe, James B and Russman, Barry and Ryan,
              Monique M and Tulinius, Mar and Voit, Thomas and Moore, Steven A
              and Lee Sweeney, H and Abresch, Richard T and Coleman, Kim L and
              Eagle, Michelle and Florence, Julaine and Gappmaier, Eduard and
              Glanzman, Allan M and Henricson, Erik and Barth, Jay and Elfring,
              Gary L and Reha, Allen and Spiegel, Robert J and O'donnell,
              Michael W and Peltz, Stuart W and Mcdonald, Craig M and
              {PTC124-GD-007-DMD STUDY GROUP}",
  journal  = "Muscle Nerve",
  volume   =  50,
  number   =  4,
  pages    = "477--487",
  month    =  oct,
  year     =  2014,
  keywords = "Duchenne muscular dystrophy; genetic; nonsense mutation; orphan;
              pediatric"
}

@ARTICLE{Pane2014-or,
  title   = "6 Minute walk test in Duchenne {MD} patients with different
             mutations: 12 month changes",
  author  = "Pane, Marika and Mazzone, Elena S and Sormani, Maria Pia and
             Messina, Sonia and Vita, Gian Luca and Fanelli, Lavinia and
             Berardinelli, Angela and Torrente, Yvan and D'Amico, Adele and
             Lanzillotta, Valentina and Viggiano, Emanuela and D'Ambrosio,
             Paola and Cavallaro, Filippo and Frosini, Silvia and Bello, Luca
             and Bonfiglio, Serena and Scalise, Roberta and De Sanctis, Roberto
             and Rolle, Enrica and Bianco, Flaviana and Van der Haawue, Marlene
             and Magri, Francesca and Palermo, Concetta and Rossi, Francesca
             and Donati, Maria Alice and Alfonsi, Chiara and Sacchini, Michele
             and Arnoldi, Maria Teresa and Baranello, Giovanni and Mongini,
             Tiziana and Pini, Antonella and Battini, Roberta and Pegoraro,
             Elena and Previtali, Stefano C and Napolitano, Sara and Bruno,
             Claudio and Politano, Luisa and Comi, Giacomo P and Bertini,
             Enrico and Morandi, Lucia and Gualandi, Francesca and Ferlini,
             Alessandra and Goemans, Nathalie and Mercuri, Eugenio",
  journal = "PLoS One",
  volume  =  9,
  number  =  1,
  pages   = "e83400",
  year    =  2014
}

@ARTICLE{Mazzone2013-gj,
  title   = "24 month longitudinal data in ambulant boys with Duchenne muscular
             dystrophy",
  author  = "Mazzone, Elena Stacy and Pane, Marika and Sormani, Maria Pia and
             Scalise, Roberta and Berardinelli, Angela and Messina, Sonia and
             Torrente, Yvan and D'Amico, Adele and Doglio, Luca and Viggiano,
             Emanuela and D'Ambrosio, Paola and Cavallaro, Filippo and Frosini,
             Silvia and Bello, Luca and Bonfiglio, Serena and De Sanctis,
             Roberto and Rolle, Enrica and Bianco, Flaviana and Magri,
             Francesca and Rossi, Francesca and Vasco, Gessica and Vita,
             Gianluca and Motta, Maria Chiara and Donati, Maria Alice and
             Sacchini, Michele and Mongini, Tiziana and Pini, Antonella and
             Battini, Roberta and Pegoraro, Elena and Previtali, Stefano and
             Napolitano, Sara and Bruno, Claudio and Politano, Luisa and Comi,
             Giacomo Pietro and Bertini, Enrico and Mercuri, Eugenio",
  journal = "PLoS One",
  volume  =  8,
  number  =  1,
  pages   = "e52512",
  year    =  2013
}

@ARTICLE{Mazzone2010-bf,
  title   = "North Star Ambulatory Assessment, 6-minute walk test and timed
             items in ambulant boys with Duchenne muscular dystrophy",
  author  = "Mazzone, Elena and Martinelli, Diego and Berardinelli, Angela and
             Messina, Sonia and D'Amico, Adele and Vasco, Gessica and Main,
             Marion and Doglio, Luca and Politano, Luisa and Cavallaro, Filippo
             and Frosini, Silvia and Bello, Luca and Carlesi, Adelina and
             Bonetti, Anna Maria and Zucchini, Elisabetta and De Sanctis,
             Roberto and Scutifero, Marianna and Bianco, Flaviana and Rossi,
             Francesca and Motta, Maria Chiara and Sacco, Annalisa and Donati,
             Maria Alice and Mongini, Tiziana and Pini, Antonella and Battini,
             Roberta and Pegoraro, Elena and Pane, Marika and Pasquini,
             Elisabetta and Bruno, Claudio and Vita, Giuseppe and de Waure,
             Chiara and Bertini, Enrico and Mercuri, Eugenio",
  journal = "Neuromuscul. Disord.",
  volume  =  20,
  number  =  11,
  pages   = "712--716",
  month   =  nov,
  year    =  2010
}

@ARTICLE{McDonald2010-un,
  title   = "The 6-minute walk test as a new outcome measure in Duchenne
             muscular dystrophy",
  author  = "McDonald, Craig M and Henricson, Erik K and Han, Jay J and
             Abresch, R Ted and Nicorici, Alina and Elfring, Gary L and
             Atkinson, Leone and Reha, Allen and Hirawat, Samit and Miller,
             Langdon L",
  journal = "Muscle Nerve",
  volume  =  41,
  number  =  4,
  pages   = "500--510",
  month   =  apr,
  year    =  2010
}

@ARTICLE{Casak2015-bq,
  title   = "{FDA} Approval Summary: Ramucirumab for Gastric Cancer",
  author  = "Casak, Sandra J and Fashoyin-Aje, Ibilola and Lemery, Steven J and
             Zhang, Lillian and Jin, Runyan and Li, Hongshan and Zhao, Liang
             and Zhao, Hong and Zhang, Hui and Chen, Huanyu and He, Kun and
             Dougherty, Michele and Novak, Rachel and Kennett, Sarah and
             Khasar, Sachia and Helms, Whitney and Keegan, Patricia and Pazdur,
             Richard",
  journal = "Clin. Cancer Res.",
  month   =  jun,
  year    =  2015
}

@ARTICLE{Senderowicz2014-ix,
  title   = "Similarities and differences in the oncology drug approval process
             between {FDA} and European Union with emphasis on in vitro
             companion diagnostics",
  author  = "Senderowicz, Adrian M and Pfaff, Otmar",
  journal = "Clin. Cancer Res.",
  volume  =  20,
  number  =  6,
  pages   = "1445--1452",
  month   =  mar,
  year    =  2014
}

@ARTICLE{Jerez2015-dm,
  title    = "Stability analysis of a Komarova type model for the interactions
              of osteoblast and osteoclast cells during bone remodeling",
  author   = "Jerez, S and Chen, B",
  journal  = "Math. Biosci.",
  volume   =  264,
  pages    = "29--37",
  month    =  jun,
  year     =  2015,
  keywords = "Bone remodeling; External agents; Nonlinear stability analysis;
              Periodic solutions"
}

@ARTICLE{Myers2011-we,
  title   = "Effects of adjusting for instrumental variables on bias and
             precision of effect estimates",
  author  = "Myers, Jessica A and Rassen, Jeremy A and Gagne, Joshua J and
             Huybrechts, Krista F and Schneeweiss, Sebastian and Rothman,
             Kenneth J and Joffe, Marshall M and Glynn, Robert J",
  journal = "Am. J. Epidemiol.",
  volume  =  174,
  number  =  11,
  pages   = "1213--1222",
  month   =  dec,
  year    =  2011
}

@ARTICLE{Myers2011-jl,
  title   = "Myers et al. Respond to ``Understanding Bias Amplification''",
  author  = "Myers, Jessica A and Rassen, Jeremy A and Gagne, Joshua J and
             Huybrechts, Krista F and Schneeweiss, Sebastian and Rothman,
             Kenneth J and Glynn, Robert J",
  journal = "Am. J. Epidemiol.",
  year    =  2011
}

@ARTICLE{Pearl2011-al,
  title   = "Invited commentary: understanding bias amplification",
  author  = "Pearl, Judea",
  journal = "Am. J. Epidemiol.",
  volume  =  174,
  number  =  11,
  pages   = "1223--7; discussion pg 1228--9",
  month   =  dec,
  year    =  2011
}

@ARTICLE{Yuen2014-xy,
  title   = "Handling missing data in a duloxetine population
             pharmacokinetic/pharmacodynamic model - imputation methods and
             selection models",
  author  = "Yuen, Eunice and Gueorguieva, Ivelina and Aarons, Leon",
  journal = "Pharm. Res.",
  volume  =  31,
  number  =  10,
  pages   = "2829--2843",
  month   =  oct,
  year    =  2014
}

@ARTICLE{Gould2015-ib,
  title    = "Joint modeling of survival and longitudinal non-survival data:
              current methods and issues. Report of the {DIA} Bayesian joint
              modeling working group",
  author   = "Gould, A L and Boye, Mark Ernest and Crowther, Michael J and
              Ibrahim, Joseph G and Quartey, George and Micallef, Sandrine and
              Bois, Frederic Y",
  journal  = "Stat. Med.",
  volume   =  34,
  number   =  14,
  pages    = "2181--2195",
  month    =  jun,
  year     =  2015,
  keywords = "applications; random effects; software; time-dependent"
}

@ARTICLE{Ibrahim2004-qe,
  title   = "{BAYESIAN} {METHODS} {FOR} {JOINT} {MODELING} {OF} {LONGITUDINAL}
             {AND} {SURVIVAL} {DATA} {WITH} {APPLICATIONS} {TO} {CANCER}
             {VACCINE} {TRIALS}",
  author  = "Ibrahim, Joseph G and Chen, Ming-Hui and Sinha, Debajyoti",
  journal = "Stat. Sin.",
  volume  =  14,
  pages   = "863--883",
  year    =  2004
}

@ARTICLE{Guo2004-me,
  title   = "Separate and Joint Modeling of Longitudinal and Event Time Data
             Using Standard Computer Packages",
  author  = "Guo, Xu and Carlin, Bradley P",
  journal = "Am. Stat.",
  volume  =  58,
  number  =  1,
  year    =  2004
}

@ARTICLE{Ji2012-vw,
  title   = "A novel mathematical model of bone remodelling cycles for
             trabecular bone at the cellular level",
  author  = "Ji, Bingbing and Genever, Paul G and Patton, Ronald J and Putra,
             Devi and Fagan, Michael J",
  journal = "Biomech. Model. Mechanobiol.",
  volume  =  11,
  number  =  7,
  pages   = "973--982",
  month   =  sep,
  year    =  2012
}

@ARTICLE{Ince2012-jc,
  title   = "Critical illness is a major determinant of midazolam clearance in
             children aged 1 month to 17 years",
  author  = "Ince, Ibrahim and de Wildt, Saskia N and Peeters, Mariska Y M and
             Murry, Daryl J and Tibboel, Dick and Danhof, Meindert and Knibbe,
             Catherijne A J",
  journal = "Ther. Drug Monit.",
  volume  =  34,
  number  =  4,
  pages   = "381--389",
  month   =  aug,
  year    =  2012
}

@BOOK{Borrud_L_Chiappa_M_Burt_V_et_al2014-lx,
  title     = "National Health and Nutrition Examination Survey: National Youth
               Fitness Survey plan, operations, and analysis, 2012",
  author    = "{Borrud L, Chiappa M, Burt V, et al}",
  publisher = "National Center for Health Statistics",
  volume    = "Vital Health Stat 2",
  year      =  2014
}

@BOOK{Centers_for_Disease_Control_and_Prevention_CDC_National_Center_for_Health_Statistics_NCHS_undated-lf,
  title     = "National Health and Nutrition Examination Survey Data",
  author    = "{Centers for Disease Control and Prevention (CDC). National
               Center for Health Statistics (NCHS)}",
  publisher = "U.S. Department of Health and Human Services, Centers for
               Disease Control and Prevention",
  address   = "Hyattsville, MD"
}

@ARTICLE{Klika2014-zx,
  title   = "A coupled mechano-biochemical model for bone adaptation",
  author  = "Klika, V{\'a}clav and P{\'e}rez, Maria Angel{\'e}s and
             Garc{\'\i}a-Aznar, Jos{\'e} Manuel and Mar{\v s}{\'\i}k, Franti{\v
             s}ek and Doblar{\'e}, Manuel",
  journal = "J. Math. Biol.",
  volume  =  69,
  number  = "6-7",
  pages   = "1383--1429",
  month   =  dec,
  year    =  2014
}

@ARTICLE{Jadhav2015-rr,
  title    = "A proposal for scientific framework enabling specific population
              drug dosing recommendations",
  author   = "Jadhav, Pravin R and Cook, Jack and Sinha, Vikram and Zhao, Ping
              and Rostami-Hodjegan, Amin and Sahasrabudhe, Vaishali and
              Stockbridge, Norman and Powell, J Robert",
  journal  = "J. Clin. Pharmacol.",
  month    =  jun,
  year     =  2015,
  keywords = "Clinical Pharmacology; Dosing and Administration; Drug Approval;
              Drug Development; Labeling; Modeling and Simulation; Specific
              populations"
}

@ARTICLE{Leder2015-jk,
  title   = "Denosumab and teriparatide transitions in postmenopausal
             osteoporosis (the {DATA-Switch} study): extension of a randomised
             controlled trial",
  author  = "Leder, Benjamin Z and Tsai, Joy N and Uihlein, Alexander V and
             Wallace, Paul M and Lee, Hang and Neer, Robert M and
             Burnett-Bowie, Sherri-Ann M",
  journal = "Lancet",
  month   =  jul,
  year    =  2015
}

@ARTICLE{Lestini2015-wy,
  title   = "Influence of the Size of Cohorts in Adaptive Design for Nonlinear
             Mixed Effects Models: An Evaluation by Simulation for a
             Pharmacokinetic and Pharmacodynamic Model for a Biomarker in
             Oncology",
  author  = "Lestini, Giulia and Dumont, Cyrielle and Mentr{\'e}, France",
  journal = "Pharm. Res.",
  month   =  jun,
  year    =  2015
}

@ARTICLE{Gayat2012-oo,
  title    = "Propensity score applied to survival data analysis through
              proportional hazards models: a Monte Carlo study",
  author   = "Gayat, Etienne and Resche-Rigon, Matthieu and Mary, Jean-Yves and
              Porcher, Rapha{\"e}l",
  journal  = "Pharm. Stat.",
  volume   =  11,
  number   =  3,
  pages    = "222--229",
  year     =  2012,
  keywords = "bias; propensity score; simulation; survival; treatment effect"
}

@ARTICLE{Blumer1998-ug,
  title   = "Clinical pharmacology of midazolam in infants and children",
  author  = "Blumer, J L",
  journal = "Clin. Pharmacokinet.",
  volume  =  35,
  number  =  1,
  pages   = "37--47",
  month   =  jul,
  year    =  1998
}

@ARTICLE{Cox2008-mg,
  title   = "The generalized {F} distribution: an umbrella for parametric
             survival analysis",
  author  = "Cox, Christopher",
  journal = "Stat. Med.",
  volume  =  27,
  number  =  21,
  pages   = "4301--4312",
  month   =  sep,
  year    =  2008
}

@ARTICLE{Peng1998-ux,
  title   = "A generalized {F} mixture model for cure rate estimation",
  author  = "Peng, Y and Dear, K B and Denham, J W",
  journal = "Stat. Med.",
  volume  =  17,
  number  =  8,
  pages   = "813--830",
  month   =  apr,
  year    =  1998
}

@ARTICLE{Jacobusse2006-pu,
  title   = "An interval scale for development of children aged 0-2 years",
  author  = "Jacobusse, Gert and van Buuren, Stef and Verkerk, Paul H",
  journal = "Stat. Med.",
  volume  =  25,
  number  =  13,
  pages   = "2272--2283",
  month   =  jul,
  year    =  2006
}

@ARTICLE{Van_Buuren2013-by,
  title    = "Growth charts of human development",
  author   = "van Buuren, Stef",
  journal  = "Stat. Methods Med. Res.",
  volume   =  23,
  number   =  4,
  pages    = "346--368",
  month    =  mar,
  year     =  2013,
  keywords = "Bayley scale; D-score diagram; Tanner stages; age continuity;
              gain score; references; stage line diagram"
}

@ARTICLE{noauthor_undated-ex,
  title = "S2.1 Parameter Estimation as Optimization"
}

@ARTICLE{Wang2007-bl,
  title   = "Derivation of various {NONMEM} estimation methods",
  author  = "Wang, Yaning",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  34,
  number  =  5,
  pages   = "575--593",
  month   =  oct,
  year    =  2007
}

@ARTICLE{Cox2007-eg,
  title   = "Parametric survival analysis and taxonomy of hazard functions for
             the generalized gamma distribution",
  author  = "Cox, Christopher and Chu, Haitao and Schneider, Michael F and
             Mu{\~n}oz, Alvaro",
  journal = "Stat. Med.",
  volume  =  26,
  number  =  23,
  pages   = "4352--4374",
  month   =  oct,
  year    =  2007
}

@ARTICLE{Vinogradova2015-ik,
  title    = "Prediction of long-term treatment outcome in {HCV} following 24
              day {PEG-IFN} alpha-2b therapy using population
              pharmacokinetic-pharmacodynamic mixture modeling and
              classification analysis",
  author   = "Vinogradova, Svetlana V and Zhudenkov, Kirill V and Benson, Neil
              and Van Der Graaf, Piet H and Demin, Oleg V and Karelina, Tatiana
              A",
  journal  = "J. Theor. Biol.",
  volume   =  382,
  pages    = "91--98",
  month    =  jul,
  year     =  2015,
  keywords = "HCV; Mixture modeling; PKPD modeling"
}

@ARTICLE{Ette2005-pv,
  title   = "Data supplementation: a pharmacokinetic/pharmacodynamic knowledge
             creation approach for characterizing an unexplored region of the
             response surface",
  author  = "Ette, Ene I and Chu, Hui-May and Godfrey, Christopher J",
  journal = "Pharm. Res.",
  volume  =  22,
  number  =  4,
  pages   = "523--531",
  month   =  apr,
  year    =  2005
}

@ARTICLE{Neuhauser2006-ye,
  title   = "How to deal with multiple endpoints in clinical trials",
  author  = "Neuh{\"a}user, Markus",
  journal = "Fundam. Clin. Pharmacol.",
  volume  =  20,
  number  =  6,
  pages   = "515--523",
  month   =  dec,
  year    =  2006
}

@ARTICLE{Senn2007-or,
  title   = "Power and sample size when multiple endpoints are considered",
  author  = "Senn, Stephen and Bretz, Frank",
  journal = "Pharm. Stat.",
  volume  =  6,
  number  =  3,
  pages   = "161--170",
  year    =  2007
}

@ARTICLE{Buil-Bruna2014-tz,
  title   = "A population pharmacodynamic model for lactate dehydrogenase and
             neuron specific enolase to predict tumor progression in small cell
             lung cancer patients",
  author  = "Buil-Bruna, N{\'u}ria and L{\'o}pez-Picazo, Jos{\'e}-Mar{\'\i}a
             and Moreno-Jim{\'e}nez, Marta and Mart{\'\i}n-Algarra, Salvador
             and Ribba, Benjamin and Troc{\'o}niz, I{\~n}aki F",
  journal = "AAPS J.",
  volume  =  16,
  number  =  3,
  pages   = "609--619",
  month   =  may,
  year    =  2014
}

@ARTICLE{Su2015-uy,
  title   = "Dexmedetomidine Pharmacology in Neonates and Infants After Open
             Heart Surgery",
  author  = "Su, Felice and Gastonguay, Marc R and Nicolson, Susan C and
             DiLiberto, Maryann and Ocampo-Pelland, Alanna and Zuppa, Athena F",
  journal = "Anesth. Analg.",
  month   =  jul,
  year    =  2015
}

@ARTICLE{Chun1997-zr,
  title   = "Quantification of latent tissue reservoirs and total body viral
             load in {HIV-1} infection",
  author  = "Chun, T W and Carruth, L and Finzi, D and Shen, X and DiGiuseppe,
             J A and Taylor, H and Hermankova, M and Chadwick, K and Margolick,
             J and Quinn, T C and Kuo, Y H and Brookmeyer, R and Zeiger, M A
             and Barditch-Crovo, P and Siliciano, R F",
  journal = "Nature",
  volume  =  387,
  number  =  6629,
  pages   = "183--188",
  month   =  may,
  year    =  1997
}

@ARTICLE{Samant2015-ro,
  title    = "Quantitative clinical pharmacology for size and age scaling in
              pediatric drug development: A systematic review",
  author   = "Samant, Tanay S and Mangal, Naveen and Lukacova, Viera and
              Schmidt, Stephan",
  journal  = "J. Clin. Pharmacol.",
  month    =  may,
  year     =  2015,
  keywords = "allometric scaling; pediatric drug development;
              physiologically-based pharmacokinetic modeling"
}

@ARTICLE{Hamberg2013-cy,
  title   = "Warfarin dose prediction in children using pharmacometric
             bridging--comparison with published pharmacogenetic dosing
             algorithms",
  author  = "Hamberg, Anna-Karin and Friberg, Lena E and Hans{\'e}us, Katarina
             and Ekman-Joelsson, Britt-Marie and Sunneg{\aa}rdh, Jan and
             Jonzon, Anders and Lundell, Bo and Jonsson, E Niclas and Wadelius,
             Mia",
  journal = "Eur. J. Clin. Pharmacol.",
  volume  =  69,
  number  =  6,
  pages   = "1275--1283",
  month   =  jun,
  year    =  2013
}

@ARTICLE{Pierrat2003-tn,
  title   = "Predicting {GFR} in children and adults: a comparison of the
             {Cockcroft-Gault}, Schwartz, and modification of diet in renal
             disease formulas",
  author  = "Pierrat, Annick and Gravier, Elisabeth and Saunders, Claude and
             Caira, Marie-V{\'e}ronique and A{\"\i}t-Djafer, Zakia and Legras,
             Bernard and Malli{\'e}, Jean-Pierre",
  journal = "Kidney Int.",
  volume  =  64,
  number  =  4,
  pages   = "1425--1436",
  month   =  oct,
  year    =  2003
}

@ARTICLE{Jiang2013-sx,
  title   = "Application of physiologically based pharmacokinetic modeling to
             predict acetaminophen metabolism and pharmacokinetics in children",
  author  = "Jiang, X-L and Zhao, P and Barrett, J S and Lesko, L J and
             Schmidt, S",
  journal = "CPT Pharmacometrics Syst Pharmacol",
  volume  =  2,
  pages   = "e80",
  year    =  2013
}

@ARTICLE{Hothorn2004-zq,
  title   = "Bagging survival trees",
  author  = "Hothorn, Torsten and Lausen, Berthold and Benner, Axel and
             Radespiel-Tr{\"o}ger, Martin",
  journal = "Stat. Med.",
  volume  =  23,
  number  =  1,
  pages   = "77--91",
  month   =  jan,
  year    =  2004
}

@ARTICLE{Radespiel-Troger2003-kv,
  title   = "Comparison of tree-based methods for prognostic stratification of
             survival data",
  author  = "Radespiel-Tr{\"o}ger, M and Rabenstein, T and Schneider, H T and
             Lausen, B",
  journal = "Artif. Intell. Med.",
  volume  =  28,
  number  =  3,
  pages   = "323--341",
  month   =  jul,
  year    =  2003
}

@ARTICLE{Lausen1996-ct,
  title    = "Evaluating the effect of optimized cutoff values in the
              assessment of prognostic factors",
  author   = "Lausen, Berthold and Schumacher, Martin",
  journal  = "Comput. Stat. Data Anal.",
  volume   =  21,
  number   =  3,
  pages    = "307--326",
  month    =  mar,
  year     =  1996,
  keywords = "Assessment of prognostic factors; Censored data; Maximally
              selected test statistics; Optimization of cutoff values"
}

@ARTICLE{Altman1994-ne,
  title   = "Dangers of using ``optimal'' cutpoints in the evaluation of
             prognostic factors",
  author  = "Altman, D G and Lausen, B and Sauerbrei, W and Schumacher, M",
  journal = "J. Natl. Cancer Inst.",
  volume  =  86,
  number  =  11,
  pages   = "829--835",
  month   =  jun,
  year    =  1994
}

@ARTICLE{Andrea_N_Edginton2006-jw,
  title   = "Physiology-based versus allometric scaling of clearance in
             children; an eliminating process based comparison",
  author  = "Andrea N Edginton, Stefan Willmann",
  journal = "Paediatr. Perinat. Drug Ther.",
  volume  =  7,
  number  =  3,
  pages   = "146--153",
  year    =  2006
}

@ARTICLE{Upreti2015-ku,
  title    = "Meta-analysis of hepatic cytochrome {P450} ontogeny to underwrite
              the prediction of pediatric pharmacokinetics using
              physiologically based pharmacokinetic modeling",
  author   = "Upreti, Vijay V and Wahlstrom, Jan L",
  journal  = "J. Clin. Pharmacol.",
  month    =  jul,
  year     =  2015,
  keywords = "Cytochrome P450; Ontogeny; Pediatrics; Pharmacokinetics;
              Physiologically based pharmacokinetic modeling"
}

@ARTICLE{Bender2005-vv,
  title   = "Generating survival times to simulate Cox proportional hazards
             models",
  author  = "Bender, Ralf and Augustin, Thomas and Blettner, Maria",
  journal = "Stat. Med.",
  volume  =  24,
  number  =  11,
  pages   = "1713--1723",
  month   =  jun,
  year    =  2005
}

@ARTICLE{Burton2006-cs,
  title   = "The design of simulation studies in medical statistics",
  author  = "Burton, Andrea and Altman, Douglas G and Royston, Patrick and
             Holder, Roger L",
  journal = "Stat. Med.",
  volume  =  25,
  number  =  24,
  pages   = "4279--4292",
  month   =  dec,
  year    =  2006
}

@ARTICLE{Ranganath2011-sl,
  title   = "Natural history of alkaptonuria revisited: analyses based on
             scoring systems",
  author  = "Ranganath, Lakshminarayan R and Cox, Trevor F",
  journal = "J. Inherit. Metab. Dis.",
  volume  =  34,
  number  =  6,
  pages   = "1141--1151",
  month   =  dec,
  year    =  2011
}

@ARTICLE{Cox2011-py,
  title   = "A quantitative assessment of alkaptonuria: testing the reliability
             of two disease severity scoring systems",
  author  = "Cox, Trevor F and Ranganath, Lakshminarayan",
  journal = "J. Inherit. Metab. Dis.",
  volume  =  34,
  number  =  6,
  pages   = "1153--1162",
  month   =  dec,
  year    =  2011
}

@ARTICLE{Tortella1989-pz,
  title   = "Dextromethorphan and neuromodulation: old drug coughs up new
             activities",
  author  = "Tortella, F C and Pellicano, M and Bowery, N G",
  journal = "Trends Pharmacol. Sci.",
  volume  =  10,
  number  =  12,
  pages   = "501--507",
  month   =  dec,
  year    =  1989
}

@ARTICLE{McCartney2004-yz,
  title   = "A qualitative systematic review of the role of
             {N-methyl-D-aspartate} receptor antagonists in preventive
             analgesia",
  author  = "McCartney, Colin J L and Sinha, Avinash and Katz, Joel",
  journal = "Anesth. Analg.",
  volume  =  98,
  number  =  5,
  pages   = "1385--400, table of contents",
  month   =  may,
  year    =  2004
}

@ARTICLE{Sang2002-qe,
  title   = "Dextromethorphan and memantine in painful diabetic neuropathy and
             postherpetic neuralgia: efficacy and dose-response trials",
  author  = "Sang, Christine N and Booher, Susan and Gilron, Ian and Parada,
             Suzan and Max, Mitchell B",
  journal = "Anesthesiology",
  volume  =  96,
  number  =  5,
  pages   = "1053--1061",
  month   =  may,
  year    =  2002
}

@ARTICLE{Blumenthal2015-tu,
  title   = "Overall response rate, progression-free survival, and overall
             survival with targeted and standard therapies in advanced
             non-small-cell lung cancer: {US} Food and Drug Administration
             trial-level and patient-level analyses",
  author  = "Blumenthal, Gideon M and Karuri, Stella W and Zhang, Hui and
             Zhang, Lijun and Khozin, Sean and Kazandjian, Dickran and Tang,
             Shenghui and Sridhara, Rajeshwari and Keegan, Patricia and Pazdur,
             Richard",
  journal = "J. Clin. Oncol.",
  volume  =  33,
  number  =  9,
  pages   = "1008--1014",
  month   =  mar,
  year    =  2015
}

@ARTICLE{Whirl-Carrillo2012-ej,
  title   = "Pharmacogenomics knowledge for personalized medicine",
  author  = "Whirl-Carrillo, M and McDonagh, E M and Hebert, J M and Gong, L
             and Sangkuhl, K and Thorn, C F and Altman, R B and Klein, T E",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  92,
  number  =  4,
  pages   = "414--417",
  month   =  oct,
  year    =  2012
}

@ARTICLE{Bhagwat2010-se,
  title   = "Searching {NCBI's} {dbSNP} database",
  author  = "Bhagwat, Medha",
  journal = "Curr. Protoc. Bioinformatics",
  volume  = "Chapter 1",
  pages   = "Unit 1.19",
  month   =  dec,
  year    =  2010
}

@ARTICLE{Chen2011-ur,
  title   = "Genetic polymorphisms in {CYP3A4} are associated with withdrawal
             symptoms and adverse reactions in methadone maintenance patients",
  author  = "Chen, Chia-Hui and Wang, Sheng-Chang and Tsou, Hsiao-Hui and Ho,
             Ing-Kang and Tian, Jia-Ni and Yu, Cheng-Jou and Hsiao, Chin-Fu and
             Chou, Sun-Yuan and Lin, Yen-Feng and Fang, Kai-Chi and Huang,
             Chieh-Liang and Su, Lien-Wen and Fang, Yong-Chun and Liu, Ming-Lun
             and Lin, Keh-Ming and Hsu, Ya-Ting and Liu, Shu Chih and Chen,
             Andrew Ch and Liu, Yu-Li",
  journal = "Pharmacogenomics",
  volume  =  12,
  number  =  10,
  pages   = "1397--1406",
  month   =  oct,
  year    =  2011
}

@ARTICLE{Abduljalil2010-vk,
  title   = "Assessment of activity levels for {CYP2D6*1}, {CYP2D6*2}, and
             {CYP2D6*41} genes by population pharmacokinetics of
             dextromethorphan",
  author  = "Abduljalil, K and Frank, D and Gaedigk, A and Klaassen, T and
             Tomalik-Scharte, D and Jetter, A and Jaehde, U and Kirchheiner, J
             and Fuhr, U",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  88,
  number  =  5,
  pages   = "643--651",
  month   =  nov,
  year    =  2010
}

@ARTICLE{Ter_Heine2014-it,
  title    = "Population pharmacokinetic modelling to assess the impact of
              {CYP2D6} and {CYP3A} metabolic phenotypes on the pharmacokinetics
              of tamoxifen and endoxifen",
  author   = "ter Heine, Rob and Binkhorst, Lisette and de Graan, Anne Joy M
              and de Bruijn, Peter and Beijnen, Jos H and Mathijssen, Ron H J
              and Huitema, Alwin D R",
  journal  = "Br. J. Clin. Pharmacol.",
  volume   =  78,
  number   =  3,
  pages    = "572--586",
  month    =  sep,
  year     =  2014,
  keywords = "CYP2D6; CYP3A; endoxifen; metabolic phenotype; nonmem; tamoxifen"
}

@ARTICLE{Anderson2011-xg,
  title   = "A maturation model for midazolam clearance",
  author  = "Anderson, Brian J and Larsson, Peter",
  journal = "Paediatr. Anaesth.",
  volume  =  21,
  number  =  3,
  pages   = "302--308",
  month   =  mar,
  year    =  2011
}

@INPROCEEDINGS{Polhamus2015-mv,
  title     = "Assessment of propensity score and Mahalanobis distance matching
               in mixed outcome data",
  booktitle = "{PAGE} 24",
  author    = "Polhamus, Daniel G and French, Jonathan L",
  year      =  2015
}

@ARTICLE{Verhagen1998-il,
  title   = "A trial of dextromethorphan in parkinsonian patients with motor
             response complications",
  author  = "Verhagen, Metman L and Blanchet, P J and van den Munckhof, P and
             Del Dotto, P andNatt{\'e}, R and Chase, T N",
  journal = "Mov. Disord.",
  volume  =  13,
  number  =  3,
  pages   = "414--417",
  year    =  1998
}

@ARTICLE{Yeh2004-ld,
  title   = "Analgesic effects of preincisional administration of
             dextromethorphan and tenoxicam following laparoscopic
             cholecystectomy",
  author  = "Yeh, C-C and Wu, C-T and Lee, M-S and al., Et",
  journal = "Acta Anaesthesiol. Scand.",
  volume  =  48,
  number  =  8,
  pages   = "1049--1053",
  year    =  2004
}

@ARTICLE{Pope2004-ez,
  title   = "Pharmacokinetics of dextromethorphan after single or multiple
             dosing in combination with quinidine in extensive and poor
             metabolizers",
  author  = "Pope, Laura E and Khalil, M H and Berg, James E and Stiles, Mark
             and Yakatan, Gerald J and Sellers, Edward M",
  journal = "J. Clin. Pharmacol.",
  volume  =  44,
  number  =  10,
  pages   = "1132--1142",
  month   =  oct,
  year    =  2004
}

@ARTICLE{Verme1992-ii,
  title   = "Pharmacokinetics of quinidine in male patients. A population
             analysis",
  author  = "Verme, C N and Ludden, T M and Clementi, W A and Harris, S C",
  journal = "Clin. Pharmacokinet.",
  volume  =  22,
  number  =  6,
  pages   = "468--480",
  month   =  jun,
  year    =  1992
}

@ARTICLE{Lehr2010-nu,
  title   = "Semi-mechanistic population pharmacokinetic drug-drug interaction
             modelling of a long half-life substrate and itraconazole",
  author  = "Lehr, Thorsten and Staab, Alexander and Trommeshauser, Dirk and
             Schaefer, Hans Guenter and Kloft, Charlotte",
  journal = "Clin. Pharmacokinet.",
  volume  =  49,
  number  =  1,
  pages   = "53--66",
  year    =  2010
}

@ARTICLE{Martin1993-rf,
  title   = "The effect of matching on the power of randomized community
             intervention studies",
  author  = "Martin, D C and Diehr, P and Perrin, E B and Koepsell, T D",
  journal = "Stat. Med.",
  volume  =  12,
  number  = "3-4",
  pages   = "329--338",
  month   =  feb,
  year    =  1993
}

@ARTICLE{Thompson1997-rv,
  title   = "The design and analysis of paired cluster randomized trials: an
             application of meta-analysis techniques",
  author  = "Thompson, S G and Pyke, S D and Hardy, R J",
  journal = "Stat. Med.",
  volume  =  16,
  number  =  18,
  pages   = "2063--2079",
  month   =  sep,
  year    =  1997
}

@ARTICLE{Albert2002-wy,
  title   = "Estimating efficacy in clinical trials with clustered binary
             responses",
  author  = "Albert, Jeffrey M",
  journal = "Stat. Med.",
  volume  =  21,
  number  =  5,
  pages   = "649--661",
  month   =  mar,
  year    =  2002
}

@ARTICLE{Knebel2015-ih,
  title   = "Modeling and simulation of the exposure-response and dropout
             pattern of guanfacine extended-release in pediatric patients with
             {ADHD}",
  author  = "Knebel, William and Rogers, Jim and Polhamus, Dan and Ermer, James
             and Gastonguay, Marc R",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  42,
  number  =  1,
  pages   = "45--65",
  month   =  feb,
  year    =  2015
}

@INPROCEEDINGS{Eudy2015-yy,
  title     = "{Sclerostin-Mediated} Osteocyte Control in Bone Remodeling:
               Extension of a Multiscale Systems Model to Consider New
               Therapies for Osteoporosis",
  booktitle = "Page 24",
  author    = "Eudy, Rena J and Gastonguay, Marc R and Baron, Kyle T and Riggs,
               Matthew M",
  volume    = "Abstr 3355",
  year      =  2015
}

@ARTICLE{Eudy2015-vx,
  title   = "A Priori Identifiability of {Target-Mediated} Drug Disposition
             Models and Approximations",
  author  = "Eudy, Rena J and Riggs, Matthew M and Gastonguay, Marc R",
  journal = "AAPS J.",
  volume  =  17,
  number  =  5,
  pages   = "1280--1284",
  month   =  sep,
  year    =  2015
}

@INPROCEEDINGS{Ocampo-Pellend2015-em,
  title     = "Model-based Meta-analysis for Development of a
               {Population-Pharmacokinetic} ({PPK}) Model for Vitamin {D3} and
               its {25OHD3} Metabolite",
  booktitle = "{PAGE} 24",
  author    = "Ocampo-Pellend, Alanna and Gastonguay, Marc R and Lorenzo,
               Joseph A and Riggs, Matthew M",
  year      =  2015
}

@ARTICLE{Eudy2015-qx,
  title   = "Connecting the Dots: Linking Osteocyte Activity and Therapeutic
             Modulation of Sclerostin by Extending a Multiscale Systems Model",
  author  = "Eudy, R J and Gastonguay, M R and Baron, K T and Riggs, M M",
  journal = "CPT: Pharmacometrics \& Systems Pharmacology",
  year    =  2015
}

@ARTICLE{Garrow1985-da,
  title   = "Quetelet's index ({W/H2}) as a measure of fatness",
  author  = "Garrow, J S and Webster, J",
  journal = "Int. J. Obes.",
  volume  =  9,
  number  =  2,
  pages   = "147--153",
  year    =  1985
}

@ARTICLE{Sylvestre2006-qw,
  title   = "Do {OSCAR} winners live longer than less successful peers? A
             reanalysis of the evidence",
  author  = "Sylvestre, Marie-Pierre and Huszti, Ella and Hanley, James A",
  journal = "Ann. Intern. Med.",
  volume  =  145,
  number  =  5,
  pages   = "361--3; discussion 392",
  month   =  sep,
  year    =  2006
}

@ARTICLE{Hayes1999-tn,
  title   = "Simple sample size calculation for cluster-randomized trials",
  author  = "Hayes, R J and Bennett, S",
  journal = "Int. J. Epidemiol.",
  volume  =  28,
  number  =  2,
  pages   = "319--326",
  month   =  apr,
  year    =  1999
}

@ARTICLE{Turner2007-qc,
  title   = "Analysis of cluster randomized cross-over trial data: a comparison
             of methods",
  author  = "Turner, Rebecca M and White, Ian R and Croudace, Tim and {PIP
             Study Group}",
  journal = "Stat. Med.",
  volume  =  26,
  number  =  2,
  pages   = "274--289",
  month   =  jan,
  year    =  2007
}

@ARTICLE{Wang2015-do,
  title    = "Bayesian multivariate augmented Beta rectangular regression
              models for patient-reported outcomes and survival data",
  author   = "Wang, Jue and Luo, Sheng",
  journal  = "Stat. Methods Med. Res.",
  month    =  jun,
  year     =  2015,
  keywords = "Augmented Beta; Beta rectangular distribution; Beta regression;
              Markov chain Monte Carlo; longitudinal data; proportional data"
}

@ARTICLE{Santoro2013-yv,
  title   = "{CYP3A5} genotype, but not {CYP3A4*1b}, {CYP3A4*22}, or
             hematocrit, predicts tacrolimus dose requirements in Brazilian
             renal transplant patients",
  author  = "Santoro, A B and Struchiner, C J and Felipe, C R and
             Tedesco-Silva, H and Medina-Pestana, J O and Suarez-Kurtz, G",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  94,
  number  =  2,
  pages   = "201--202",
  month   =  aug,
  year    =  2013
}

@ARTICLE{Zheng2012-ov,
  title   = "Measurement and compartmental modeling of the effect of {CYP3A5}
             gene variation on systemic and intrarenal tacrolimus disposition",
  author  = "Zheng, S and Tasnif, Y and Hebert, M F and Davis, C L and Shitara,
             Y and Calamia, J C and Lin, Y S and Shen, D D and Thummel, K E",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  92,
  number  =  6,
  pages   = "737--745",
  month   =  dec,
  year    =  2012
}

@ARTICLE{Tucker2005-bt,
  title   = "Polymorphisms in cytochrome {P4503A5} ({CYP3A5}) may be associated
             with race and tumor characteristics, but not metabolism and side
             effects of tamoxifen in breast cancer patients",
  author  = "Tucker, April N and Tkaczuk, Katherine A and Lewis, Lynn M and
             Tomic, Dragana and Lim, Chang K and Flaws, Jodi A",
  journal = "Cancer Lett.",
  volume  =  217,
  number  =  1,
  pages   = "61--72",
  month   =  jan,
  year    =  2005
}

@ARTICLE{Wassenaar2015-co,
  title   = "{UGT1A} and {UGT2B} genetic variation alters nicotine and
             nitrosamine glucuronidation in european and african american
             smokers",
  author  = "Wassenaar, Catherine A and Conti, David V and Das, Soma and Chen,
             Peixian and Cook, Edwin H and Ratain, Mark J and Benowitz, Neal L
             and Tyndale, Rachel F",
  journal = "Cancer Epidemiol. Biomarkers Prev.",
  volume  =  24,
  number  =  1,
  pages   = "94--104",
  month   =  jan,
  year    =  2015
}

@TECHREPORT{noauthor_2015-ve,
  title       = "Duchenne Muscular Dystrophy and Related Dystrophinopathies:
                 Developing Drugs for Treatment",
  institution = "U.S. Department of Health and Human Services Food and Drug
                 Administration Center for Drug Evaluation and Research",
  year        =  2015
}

@ARTICLE{Shefner2004-oj,
  title   = "A clinical trial of creatine in {ALS}",
  author  = "Shefner, J M and Cudkowicz, M E and Schoenfeld, D and Conrad, T
             and Taft, J and Chilton, M and Urbinelli, L and Qureshi, M and
             Zhang, H and Pestronk, A and Caress, J and Donofrio, P and
             Sorenson, E and Bradley, W and Lomen-Hoerth, C and Pioro, E and
             Rezania, K and Ross, M and Pascuzzi, R and Heiman-Patterson, T and
             Tandan, R and Mitsumoto, H and Rothstein, J and Smith-Palmer, T
             and MacDonald, D and Burke, D and {NEALS Consortium}",
  journal = "Neurology",
  volume  =  63,
  number  =  9,
  pages   = "1656--1661",
  month   =  nov,
  year    =  2004
}

@ARTICLE{Gatault2015-ma,
  title    = "Therapeutic drug monitoring of eculizumab: Rationale for an
              individualized dosing schedule",
  author   = "Gatault, Philippe and Brachet, Guillaume and Ternant, David and
              Degenne, Danielle and R{\'e}cipon, Guillaume and Barbet,
              Christelle and Gyan, Emmanuel and Gouilleux-Gruart, Val{\'e}rie
              and Bordes, C{\'e}cile and Farrell, Alexandra and Halimi, Jean
              Michel and Watier, Herv{\'e}",
  journal  = "MAbs",
  pages    = "1--7",
  month    =  sep,
  year     =  2015,
  keywords = "Eculizumab; Hemolytic uremic syndrome; Paroxysmal nocturnal
              hemoglobinuria; Pharmacokinetics; Thrombotic microangiopathy"
}

@BOOK{Rizopoulos2012-mv,
  title     = "Joint models for longitudinal and time-to-event data: with
               applications in {R}",
  author    = "Rizopoulos, Dimitris",
  publisher = "CRC Press",
  volume    =  6,
  series    = "Chapman \& Hall/CRC biostatistics series",
  year      =  2012,
  address   = "Boca Raton"
}

@ARTICLE{Jadhav2015-gw,
  title    = "A proposal for scientific framework enabling specific population
              drug dosing recommendations",
  author   = "Jadhav, Pravin R and Cook, Jack and Sinha, Vikram and Zhao, Ping
              and Rostami-Hodjegan, Amin and Sahasrabudhe, Vaishali and
              Stockbridge, Norman and Powell, J Robert",
  journal  = "J. Clin. Pharmacol.",
  volume   =  55,
  number   =  10,
  pages    = "1073--1078",
  year     =  2015,
  keywords = "clinical pharmacology, specific populations, dosing and
              administration, labeling, drug development, drug approval,
              modeling and simulation"
}

@ARTICLE{Van_Schaick2015-jo,
  title   = "A semi-mechanistic model of bone mineral density and bone turnover
             based on a circular model of bone remodeling",
  author  = "van Schaick, Erno and Zheng, Jenny and Perez Ruixo, Juan Jose and
             Gieschke, Ronald and Jacqmin, Philippe",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  42,
  number  =  4,
  pages   = "315--332",
  month   =  aug,
  year    =  2015
}

@ARTICLE{Zheng2015-sy,
  title   = "Using early biomarker data to predict long-term bone mineral
             density: application of semi-mechanistic bone cycle model on
             denosumab data",
  author  = "Zheng, Jenny and van Schaick, Erno and Wu, Liviawati Sutjandra and
             Jacqmin, Philippe and Perez Ruixo, Juan Jose",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  42,
  number  =  4,
  pages   = "333--347",
  month   =  aug,
  year    =  2015
}

@ARTICLE{Aarons2004-ol,
  title   = "Pharmacodynamics of controlled release verapamil in patients with
             hypertension: an analysis using spline functions",
  author  = "Aarons, Leon and Baxter, Claire and Gupta, Suneel",
  journal = "Biopharm. Drug Dispos.",
  volume  =  25,
  number  =  5,
  pages   = "219--225",
  month   =  jul,
  year    =  2004
}

@ARTICLE{Yu2008-ai,
  title   = "Individual Prediction in Prostate Cancer Studies Using a Joint
             Longitudinal {Survival--Cure} Model",
  author  = "Yu, Menggang and Taylor, Jeremy M G and Sandler, Howard M",
  journal = "J. Am. Stat. Assoc.",
  volume  =  103,
  number  =  481,
  pages   = "178--187",
  year    =  2008
}

@INPROCEEDINGS{Ocampo-Pelland2015-ra,
  title     = "{Model-Based} {Meta-Analysis} to Develop a Vitamin {D}
               {ParentMetabolite} {Population-Pharmacokinetic} Model",
  booktitle = "Abstracts Accepted for American Conference on Pharmacometrics
               2015 ({ACoP6})",
  author    = "Ocampo-Pelland, A S and Gastonguay, M R and French, J L and
               Riggs, M M",
  year      =  2015
}

@ARTICLE{Eudy2015-be,
  title   = "Linking a Mechanistic Model of Bone Mineral Density to a
             {Time-to-Event} Model to Evaluate Effects of Various Therapies on
             Fracture Risk in Postmenopausal Women with Osteoporosis",
  author  = "Eudy, R J and Gillespie, W R and Riggs, M M and Gastonguay, M R",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  42,
  number  = "W-28",
  pages   = "S87--S88",
  year    =  2015
}

@ARTICLE{Kristoffersson2015-br,
  title    = "Inter occasion variability in individual optimal design",
  author   = "Kristoffersson, Anders N and Friberg, Lena E and Nyberg, Joakim",
  journal  = "J. Pharmacokinet. Pharmacodyn.",
  month    =  oct,
  year     =  2015,
  keywords = "Bayesian; Fisher information; Inter occasion variability (IOV);
              Maximum a posteriori (MAP); Optimal design (OD); Pharmacometrics;
              Shrinkage"
}

@ARTICLE{Sebastian-Leon2014-cj,
  title   = "Understanding disease mechanisms with models of signaling pathway
             activities",
  author  = "Sebastian-Leon, Patricia and Vidal, Enrique and Minguez, Pablo and
             Conesa, Ana and Tarazona, Sonia and Amadoz, Alicia and Armero,
             Carmen and Salavert, Francisco and Vidal-Puig, Antonio and
             Montaner, David and Dopazo, Joaqu{\'\i}n",
  journal = "BMC Syst. Biol.",
  volume  =  8,
  pages   = "121",
  year    =  2014
}

@ARTICLE{Cella2005-ig,
  title   = "Validation of the Functional Assessment of Chronic Illness Therapy
             Fatigue Scale relative to other instrumentation in patients with
             rheumatoid arthritis",
  author  = "Cella, David and Yount, Susan and Sorensen, Mark and Chartash,
             Elliot and Sengupta, Nishan and Grober, James",
  journal = "J. Rheumatol.",
  volume  =  32,
  number  =  5,
  pages   = "811--819",
  month   =  may,
  year    =  2005
}

@ARTICLE{Sharma2015-vv,
  title   = "Resampling the {N9741} trial to compare tumor dynamic versus
             conventional end points in randomized phase {II} trials",
  author  = "Sharma, Manish R and Gray, Elizabeth and Goldberg, Richard M and
             Sargent, Daniel J and Karrison, Theodore G",
  journal = "J. Clin. Oncol.",
  volume  =  33,
  number  =  1,
  pages   = "36--41",
  month   =  jan,
  year    =  2015
}

@ARTICLE{Mandrioli2008-uj,
  title   = "Benzodiazepine metabolism: an analytical perspective",
  author  = "Mandrioli, Roberto and Mercolini, Laura and Raggi, Maria Augusta",
  journal = "Curr. Drug Metab.",
  volume  =  9,
  number  =  8,
  pages   = "827--844",
  month   =  oct,
  year    =  2008
}

@ARTICLE{Burzykowski2004-vz,
  title     = "The validation of surrogate end points by using data from
               randomized clinical trials: a case-study in advanced colorectal
               cancer",
  author    = "Burzykowski, Tomasz and Molenberghs, Geert and Buyse, Marc",
  journal   = "J. R. Stat. Soc. Ser. A Stat. Soc.",
  publisher = "Blackwell Publishing",
  volume    =  167,
  number    =  1,
  pages     = "103--124",
  year      =  2004,
  keywords  = "Copula model, Meta-analysis, Plackett copula, Surrogate end
               point, Survival, Tumour response, Two-stage model"
}

@INCOLLECTION{Quignot2014-dn,
  title     = "Extrapolating In Vitro Results to Predict Human Toxicity",
  booktitle = "In Vitro Toxicology Systems",
  author    = "Quignot, Nadia and Hamon, J{\'e}r{\'e}my and Bois, Frederic Y",
  publisher = "Springer",
  pages     = "531--550",
  year      =  2014
}

@ARTICLE{Leclerc_undated-ml,
  title     = "Investigation of acetaminophen toxicity in {HepG2/C3a}
               microscale cultures using a system biology model of glutathione
               depletion",
  author    = "Leclerc, Eric and Hamon, Jeremy and Claude, Isabelle and
               Jellali, Rachid and Naudot, Marie and Bois, Frederic",
  journal   = "Cell Biol. Toxicol.",
  publisher = "Springer",
  volume    =  31,
  number    =  3,
  pages     = "173--185"
}

@ARTICLE{Hamon2015-gl,
  title     = "Quantitative invitro to invivo extrapolation of tissues toxicity",
  author    = "Hamon, J{\'e}r{\'e}my and Renner, Maria and Jamei, Masoud and
               Lukas, Arno and Kopp-Schneider, Annette and Bois,
               Fr{\'e}d{\'e}ric Y",
  journal   = "Toxicol. In Vitro",
  publisher = "Elsevier",
  year      =  2015
}

@ARTICLE{Leclerc2014-cf,
  title     = "Integration of pharmacokinetic and {NRF2} system biology models
               to describe reactive oxygen species production and subsequent
               glutathione depletion in liver microfluidic biochips after
               flutamide exposure",
  author    = "Leclerc, Eric and Hamon, Jeremy and Legendre, Audrey and Bois,
               Frederic Y",
  journal   = "Toxicol. In Vitro",
  publisher = "Elsevier",
  volume    =  28,
  number    =  7,
  pages     = "1230--1241",
  year      =  2014
}

@ARTICLE{Leclerc2015-lf,
  title     = "Investigation of ifosfamide and chloroacetaldehyde renal
               toxicity through integration of in vitro liver--kidney
               microfluidic data and pharmacokinetic-system biology models",
  author    = "Leclerc, Eric and Hamon, Jeremy and Bois, Frederic Yves",
  journal   = "J. Appl. Toxicol.",
  publisher = "Wiley Online Library",
  year      =  2015
}

@ARTICLE{Kim2015-ao,
  title   = "Cancer Drugs Approved on the Basis of a Surrogate End Point and
             Subsequent Overall Survival: An Analysis of 5 Years of {US} Food
             and Drug Administration Approvals",
  author  = "Kim, Chul and Prasad, Vinay",
  journal = "JAMA Intern. Med.",
  pages   = "1--2",
  month   =  oct,
  year    =  2015
}

@ARTICLE{Lon2015-ay,
  title    = "Modeling effects of dexamethasone on disease progression of bone
              mineral density in collagen-induced arthritic rats",
  author   = "Lon, Hoi-Kei and DuBois, Debra C and Earp, Justin C and Almon,
              Richard R and Jusko, William J",
  journal  = "Pharmacol Res Perspect",
  volume   =  3,
  number   =  5,
  pages    = "e00169",
  month    =  oct,
  year     =  2015,
  keywords = "Biomarkers; bone modeling; dexamethasone; pharmacodynamics;
              systems model"
}

@ARTICLE{Hallow2014-ca,
  title    = "A model-based approach to investigating the pathophysiological
              mechanisms of hypertension and response to antihypertensive
              therapies: extending the Guyton model",
  author   = "Hallow, K Melissa and Lo, Arthur and Beh, Jeni and Rodrigo, Manoj
              and Ermakov, Sergey and Friedman, Stuart and de Leon, Hector and
              Sarkar, Anamika and Xiong, Yuan and Sarangapani, Ramesh and
              Schmidt, Henning and Webb, Randy and Kondic, Anna Georgieva",
  journal  = "Am. J. Physiol. Regul. Integr. Comp. Physiol.",
  volume   =  306,
  number   =  9,
  pages    = "R647--62",
  month    =  may,
  year     =  2014,
  keywords = "blood pressure; hypertension; renin-angiotensin-aldosterone
              system; systems biology"
}

@ARTICLE{Philip2014-wg,
  title   = "Historical controls for metastatic pancreatic cancer: benchmarks
             for planning and analyzing single-arm phase {II} trials",
  author  = "Philip, Philip A and Chansky, Kari and LeBlanc, Michael and
             Rubinstein, Lawrence and Seymour, Lesley and Ivy, S Percy and
             Alberts, Steven R and Catalano, Paul J and Crowley, John",
  journal = "Clin. Cancer Res.",
  volume  =  20,
  number  =  16,
  pages   = "4176--4185",
  month   =  aug,
  year    =  2014
}

@ARTICLE{Fontes_Jardim2015-qu,
  title   = "Impact of a {Biomarker-Based} Strategy on Oncology Drug
             Development: A Meta-analysis of Clinical Trials Leading to {FDA}
             Approval",
  author  = "Fontes Jardim, Denis L and Schwaederle, Maria and Wei, Caimiao and
             Lee, J Jack and Hong, David S and Eggermont, Alexander M and
             Schilsky, Richard L and Mendelsohn, John and Lazar, Vladimir and
             Kurzrock, Razelle",
  journal = "J. Natl. Cancer Inst.",
  volume  =  107,
  number  =  11,
  month   =  nov,
  year    =  2015
}

@ARTICLE{An2015-yd,
  title   = "Evaluating Continuous Tumor {Measurement-Based} Metrics as Phase
             {II} Endpoints for Predicting Overall Survival",
  author  = "An, Ming-Wen and Dong, Xinxin and Meyers, Jeffrey and Han, Yu and
             Grothey, Axel and Bogaerts, Jan and Sargent, Daniel J and
             Mandrekar, Sumithra J and {Response Evaluation Criteria in Solid
             Tumors Steering Committee}",
  journal = "J. Natl. Cancer Inst.",
  volume  =  107,
  number  =  11,
  month   =  nov,
  year    =  2015
}

@ARTICLE{Prasad2015-mb,
  title   = "The Strength of Association Between Surrogate End Points and
             Survival in Oncology: A Systematic Review of {Trial-Level}
             Meta-analyses",
  author  = "Prasad, Vinay and Kim, Chul and Burotto, Mauricio and Vandross,
             Andrae",
  journal = "JAMA Intern. Med.",
  volume  =  175,
  number  =  8,
  pages   = "1389--1398",
  month   =  aug,
  year    =  2015
}

@ARTICLE{Rebora2015-zo,
  title    = "Using multiple timescale models for the evaluation of a
              time-dependent treatment",
  author   = "Rebora, Paola and Galimberti, Stefania and Valsecchi, Maria
              Grazia",
  journal  = "Stat. Med.",
  volume   =  34,
  number   =  28,
  pages    = "3648--3660",
  month    =  dec,
  year     =  2015,
  keywords = "hazard; multiple timescales; piece-wise Poisson model.; survival;
              time-dependent treatment"
}

@ARTICLE{Magnusdottir2015-oj,
  title    = "Simultaneous estimation of parameters in the bivariate Emax model",
  author   = "Magnusdottir, Bergrun T and Nyquist, Hans",
  journal  = "Stat. Med.",
  volume   =  34,
  number   =  28,
  pages    = "3714--3723",
  month    =  dec,
  year     =  2015,
  keywords = "Emax model; clinical trials; multi-response nonlinear models;
              system estimation"
}

@ARTICLE{Ibrahim2015-ij,
  title    = "The power prior: theory and applications",
  author   = "Ibrahim, Joseph G and Chen, Ming-Hui and Gwon, Yeongjin and Chen,
              Fang",
  journal  = "Stat. Med.",
  volume   =  34,
  number   =  28,
  pages    = "3724--3749",
  month    =  dec,
  year     =  2015,
  keywords = "Bayesian design; borrowing; clinical trials; discounting;
              historical data; informative prior"
}

@ARTICLE{Baayen2015-ks,
  title    = "Confidence bounds for nonlinear dose-response relationships",
  author   = "Baayen, C and Hougaard, P",
  journal  = "Stat. Med.",
  volume   =  34,
  number   =  27,
  pages    = "3546--3562",
  month    =  nov,
  year     =  2015,
  keywords = "confidence intervals; dose-finding; nonlinear models; percentile
              bootstrap; profile likelihood"
}

@ARTICLE{Lagishetty2015-ou,
  title    = "Evaluation of Approaches to Deal with {Low-Frequency} Nuisance
              Covariates in Population Pharmacokinetic Analyses",
  author   = "Lagishetty, Chakradhar V and Duffull, Stephen B",
  journal  = "AAPS J.",
  volume   =  17,
  number   =  6,
  pages    = "1388--1394",
  month    =  nov,
  year     =  2015,
  keywords = "Box-Cox transformation; case deletion and pharmacometrics; fixed
              effect parameter; nuisance covariate"
}

@ARTICLE{Largajolli2015-yo,
  title    = "Visual Predictive Check in Models with {Time-Varying} Input
              Function",
  author   = "Largajolli, Anna and Bertoldo, Alessandra and Campioni, Marco and
              Cobelli, Claudio",
  journal  = "AAPS J.",
  volume   =  17,
  number   =  6,
  pages    = "1455--1463",
  month    =  nov,
  year     =  2015,
  keywords = "mixed-effect modeling; model diagnostic; models using input
              function; visual predictive check"
}

@ARTICLE{Sardu2015-uc,
  title    = "Biomarker- versus drug-driven tumor growth inhibition models: an
              equivalence analysis",
  author   = "Sardu, Maria Luisa and Poggesi, Italo and De Nicolao, Giuseppe",
  journal  = "J. Pharmacokinet. Pharmacodyn.",
  volume   =  42,
  number   =  6,
  pages    = "611--626",
  month    =  dec,
  year     =  2015,
  keywords = "Biomarkers; Causal pathways; PK--PD models; Simeoni model; Tumor
              growth inhibition; Xenograft experiments"
}

@ARTICLE{Kristoffersson2015-tp,
  title    = "Inter occasion variability in individual optimal design",
  author   = "Kristoffersson, Anders N and Friberg, Lena E and Nyberg, Joakim",
  journal  = "J. Pharmacokinet. Pharmacodyn.",
  volume   =  42,
  number   =  6,
  pages    = "735--750",
  month    =  dec,
  year     =  2015,
  keywords = "Bayesian; Fisher information; Inter occasion variability (IOV);
              Maximum a posteriori (MAP); Optimal design (OD); Pharmacometrics;
              Shrinkage"
}

@ARTICLE{Wynant2015-wf,
  title    = "Flexible estimation of survival curves conditional on non-linear
              and time-dependent predictor effects",
  author   = "Wynant, Willy and Abrahamowicz, Michal",
  journal  = "Stat. Med.",
  month    =  nov,
  year     =  2015,
  keywords = "full likelihood; predictive models; regression splines; survival
              analysis; time-varying effects"
}

@ARTICLE{Laffont2014-wv,
  title     = "Multivariate Analysis of Longitudinal Ordinal Data With Mixed
               Effects Models, With Application to Clinical Outcomes in
               Osteoarthritis",
  author    = "Laffont, Celine Marielle and Vandemeulebroecke, Marc and
               Concordet, Didier",
  journal   = "J. Am. Stat. Assoc.",
  publisher = "Taylor \& Francis",
  volume    =  109,
  number    =  507,
  pages     = "955--966",
  month     =  jul,
  year      =  2014
}

@ARTICLE{Padhi2014-cw,
  title    = "Multiple doses of sclerostin antibody romosozumab in healthy men
              and postmenopausal women with low bone mass: a randomized,
              double-blind, placebo-controlled study",
  author   = "Padhi, Desmond and Allison, Mark and Kivitz, Alan J and
              Gutierrez, Maria J and Stouch, Brian and Wang, Christine and
              Jang, Graham",
  journal  = "J. Clin. Pharmacol.",
  volume   =  54,
  number   =  2,
  pages    = "168--178",
  month    =  feb,
  year     =  2014,
  keywords = "AMG 785; CDP7851; bone mineral density; pharmacodynamics;
              pharmacokinetics; romosozumab; sclerostin"
}

@ARTICLE{Recker2015-mo,
  title    = "A randomized, double-blind phase 2 clinical trial of blosozumab,
              a sclerostin antibody, in postmenopausal women with low bone
              mineral density",
  author   = "Recker, Robert R and Benson, Charles T and Matsumoto, Toshio and
              Bolognese, Michael A and Robins, Deborah A and Alam, Jahangir and
              Chiang, Alan Y and Hu, Leijun and Krege, John H and Sowa, Hideaki
              and Mitlak, Bruce H and Myers, Stephen L",
  journal  = "J. Bone Miner. Res.",
  volume   =  30,
  number   =  2,
  pages    = "216--224",
  month    =  feb,
  year     =  2015,
  keywords = "ANABOLICS; BLOSOZUMAB; BONE MINERAL DENSITY; OSTEOPOROSIS
              TREATMENT; SCLEROSTIN ANTIBODY"
}

@ARTICLE{Recknor2015-nr,
  title    = "The Effect of Discontinuing Treatment With Blosozumab: Follow-up
              Results of a Phase 2 Randomized Clinical Trial in Postmenopausal
              Women With Low Bone Mineral Density",
  author   = "Recknor, Christopher P and Recker, Robert R and Benson, Charles T
              and Robins, Deborah A and Chiang, Alan Y and Alam, Jahangir and
              Hu, Leijun and Matsumoto, Toshio and Sowa, Hideaki and Sloan,
              John H and Konrad, Robert J and Mitlak, Bruce H and Sipos, Adrien
              A",
  journal  = "J. Bone Miner. Res.",
  volume   =  30,
  number   =  9,
  pages    = "1717--1725",
  month    =  sep,
  year     =  2015,
  keywords = "ANABOLICS; BLOSOZUMAB; DXA; OSTEOPOROSIS; SCLEROSTIN ANTIBODY"
}

@ARTICLE{McColm2014-su,
  title    = "Single- and multiple-dose randomized studies of blosozumab, a
              monoclonal antibody against sclerostin, in healthy postmenopausal
              women",
  author   = "McColm, Juliet and Hu, Leijun and Womack, Theresa and Tang, Cheng
              Cai and Chiang, Alan Y",
  journal  = "J. Bone Miner. Res.",
  volume   =  29,
  number   =  4,
  pages    = "935--943",
  month    =  apr,
  year     =  2014,
  keywords = "ANABOLICS; BIOCHEMICAL MARKERS OF BONE TURNOVER; CLINICAL TRIALS;
              DXA; OSTEOPOROSIS"
}

@INPROCEEDINGS{Keaveny2015-la,
  title     = "Romosozumab Improves Strength at the Lumbar Spine and Hip in
               Postmenopausal Women With Low Bone Mass Compared With
               Teriparatide",
  booktitle = "{ASBMR} 2015 Annual Meeting",
  author    = "Keaveny, Tony",
  year      =  2015
}

@ARTICLE{Jonker2005-mu,
  title   = "A pharmacokinetic-pharmacodynamic model for the quantitative
             prediction of dofetilide clinical {QT} prolongation from human
             ether-a-go-go-related gene current inhibition data",
  author  = "Jonker, Dani{\"e}l M and Kenna, Leslie A and Leishman, Derek and
             Wallis, Rob and Milligan, Peter A and Jonsson, E Niclas",
  journal = "Clin. Pharmacol. Ther.",
  volume  =  77,
  number  =  6,
  pages   = "572--582",
  month   =  jun,
  year    =  2005
}

@ARTICLE{Garcia2015-fj,
  title    = "Identifiability of {PBPK} models with applications to
              dimethylarsinic acid exposure",
  author   = "Garcia, Ramon I and Ibrahim, Joseph G and Wambaugh, John F and
              Kenyon, Elaina M and Setzer, R Woodrow",
  journal  = "J. Pharmacokinet. Pharmacodyn.",
  volume   =  42,
  number   =  6,
  pages    = "591--609",
  month    =  dec,
  year     =  2015,
  keywords = "Dimethyl arsinic acid; Gibbs sampling; Identifiability;
              Metropolis--Hasting algorithm; PBPK Models"
}

@ARTICLE{Thouverey2015-xk,
  title     = "Sclerostin inhibits osteoblast differentiation without affecting
               {BMP2/SMAD1/5} or {Wnt3a/{$[$}beta{$]$}-catenin} signaling but
               through activation of platelet-derived growth factor receptor
               signaling in vitro",
  author    = "Thouverey, Cyril and Caverzasio, Joseph",
  journal   = "BoneKEy Rep",
  publisher = "International Bone \& Mineral Society",
  volume    =  4,
  month     =  nov,
  year      =  2015
}

@ARTICLE{Xu2014-nz,
  title   = "Modeling of bounded outcome scores with data on the boundaries:
             application to disability assessment for dementia scores in
             Alzheimer's disease",
  author  = "Xu, Xu Steven and Samtani, Mahesh and Yuan, Min and Nandy, Partha",
  journal = "AAPS J.",
  volume  =  16,
  number  =  6,
  pages   = "1271--1281",
  month   =  nov,
  year    =  2014
}

@ARTICLE{Smithson2006-tx,
  title   = "A better lemon squeezer? Maximum-likelihood regression with
             beta-distributed dependent variables",
  author  = "Smithson, Michael and Verkuilen, Jay",
  journal = "Psychol. Methods",
  volume  =  11,
  number  =  1,
  pages   = "54--71",
  month   =  mar,
  year    =  2006
}

@ARTICLE{Conrado2014-gy,
  title   = "An updated Alzheimer's disease progression model: incorporating
             non-linearity, beta regression, and a third-level random effect in
             {NONMEM}",
  author  = "Conrado, Daniela J and Denney, William S and Chen, Danny and Ito,
             Kaori",
  journal = "J. Pharmacokinet. Pharmacodyn.",
  volume  =  41,
  number  =  6,
  pages   = "581--598",
  month   =  dec,
  year    =  2014
}

@TECHREPORT{Downie2014-ke,
  title       = "A phase 1, single-center, randomized, double-blind, study to
                 assess the pharmacokinetics, safety and tolerability of
                 sinigle and multiple doses of {AVP-786} (Deuterated
                 Dextromethorphan) in healthy volunteers",
  author      = "Downie, Kylie",
  institution = "Avanir Pharmaceuticals, Inc.",
  month       =  jan,
  year        =  2014
}

@TECHREPORT{Downie2014-iz,
  title       = "A phase 1, single-centre, randomised, open-label study to
                 assess the pharmacokinetics, safety and tolerability of
                 {AVP-786} (Deuterated [D6] Dextromethorphan
                 {Hydrobromide/Quinidine} Sulfate) in healthy volunteers",
  author      = "Downie, Kylie",
  institution = "Avanir Pharmaceuticals, Inc.",
  month       =  mar,
  year        =  2014
}

@TECHREPORT{Schneider2015-sb,
  title       = "Determination of Quinidine in Human Plasma Samples from
                 {14-AVP-786-102} by {HPLC} with {MS/MS} Detection",
  author      = "Schneider, Tom",
  institution = "Avanir Pharmaceuticals, Inc.",
  month       =  jul,
  year        =  2015
}

@TECHREPORT{Schneider2015-hx,
  title       = "Determination of d6-Dextromethorphan ({d6-DM)}, d3-Dextrorphan
                 ({d3-DX)}, and d3-3-Methoxymorphinan ({d3-3-MM}) in Human
                 Plasma Samples from {14-AVP-786-102} by {HPLC} with {MS/MS}
                 Detection",
  author      = "Schneider, Tom",
  institution = "Avanir Pharmaceuticals, Inc.",
  month       =  jul,
  year        =  2015
}

@TECHREPORT{Schneider2015-nj,
  title       = "Determination of Dextromethorphan ({DM)}, Dextrorphan ({DX})
                 and 3-Methoxymorphinan ({3-MM}) in Human Plasma Samples
                 {14-AVP-786-102} by {HPLC} with {MS/MS} Detection",
  author      = "Schneider, Tom",
  institution = "Avanir Pharmaceuticals, Inc.",
  month       =  jul,
  year        =  2015
}

@TECHREPORT{Downie2014-zf,
  title       = "A phase 1, single-center, open-label, sequential drug
                 interaction study between avp-786 (deuterated [d6]
                 dextromethorphan hydrobromide [dm]/quinidine sulfate [q]) and
                 paroxetine and between avp-786 and duloxetine in healthy
                 subjects",
  author      = "Downie, Kylie",
  institution = "Avanir Pharmaceuticals",
  month       =  sep,
  year        =  2014
}

@ARTICLE{Hoshen2002-uc,
  title   = "Mathematical modelling of malaria chemotherapy: combining
             artesunate and mefloquine",
  author  = "Hoshen, M B and Stein, W D and Ginsburg, H",
  journal = "Parasitology",
  volume  =  124,
  number  = "Pt 1",
  pages   = "9--15",
  month   =  jan,
  year    =  2002
}

@ARTICLE{Hoshen2001-qc,
  title   = "Pharmacokinetic-pharmacodynamic modelling of the antimalarial
             activity of mefloquine",
  author  = "Hoshen, M B and Stein, W D and Ginsburg, H D",
  journal = "Parasitology",
  volume  =  123,
  number  = "Pt 4",
  pages   = "337--346",
  month   =  oct,
  year    =  2001
}

@ARTICLE{Hoshen2000-nm,
  title   = "Mathematical modelling of the chemotherapy of Plasmodium
             falciparum malaria with artesunate: postulation of 'dormancy', a
             partial cytostatic effect of the drug, and its implication for
             treatment regimens",
  author  = "Hoshen, M B and Na-Bangchang, K and Stein, W D and Ginsburg, H",
  journal = "Parasitology",
  volume  = "121 ( Pt 3)",
  pages   = "237--246",
  month   =  sep,
  year    =  2000
}

@ARTICLE{Hoshen2000-bp,
  title   = "Mathematical modelling of the within-host dynamics of Plasmodium
             falciparum",
  author  = "Hoshen, M B and Heinrich, R and Stein, W D and Ginsburg, H",
  journal = "Parasitology",
  volume  = "121 ( Pt 3)",
  pages   = "227--235",
  month   =  sep,
  year    =  2000
}

@ARTICLE{Mould2015-zl,
  title    = "Commentary: Why Therapeutic Drug Monitoring is Needed for
              Monoclonal Antibodies and How Do We Implement This?",
  author   = "Mould, Diane R",
  journal  = "Clin. Pharmacol. Ther.",
  month    =  oct,
  year     =  2015,
  keywords = "Therapeutic drug monitoring; individualized therapy; inflammatory
              disease; monoclonal antibodies; oncology"
}

@ARTICLE{Mould2015-zd,
  title   = "The Pharmacokinetics of Biologics: A Primer",
  author  = "Mould, Diane R",
  journal = "Dig. Dis.",
  volume  = "33 Suppl 1",
  pages   = "61--69",
  month   =  sep,
  year    =  2015
}

@ARTICLE{Dotan2014-hm,
  title   = "Patient factors that increase infliximab clearance and shorten
             half-life in inflammatory bowel disease: a population
             pharmacokinetic study",
  author  = "Dotan, Iris and Ron, Yulia and Yanai, Henit and Becker, Stuart and
             Fishman, Sigal and Yahav, Lior and Ben Yehoyada, Merav and Mould,
             Diane R",
  journal = "Inflamm. Bowel Dis.",
  volume  =  20,
  number  =  12,
  pages   = "2247--2259",
  month   =  dec,
  year    =  2014
}

@ARTICLE{Mould2014-uz,
  title   = "Dashboard systems: implementing pharmacometrics from bench to
             bedside",
  author  = "Mould, Diane R and Upton, Richard N and Wojciechowski, Jessica",
  journal = "AAPS J.",
  volume  =  16,
  number  =  5,
  pages   = "925--937",
  month   =  sep,
  year    =  2014
}

@ARTICLE{Ghosh2014-fj,
  title    = "New tools and approaches for improved management of inflammatory
              bowel diseases",
  author   = "Ghosh, Subrata and Pariente, Benjamin and Mould, Diane R and
              Schreiber, Stefan and Petersson, Joel and Hommes, Daniel",
  journal  = "J. Crohns. Colitis",
  volume   =  8,
  number   =  10,
  pages    = "1246--1253",
  month    =  oct,
  year     =  2014,
  keywords = "Crohn's disease; Disease monitoring; Healthcare delivery;
              Individualised medicine; Ulcerative colitis; Value"
}

@ARTICLE{Kay2012-nm,
  title   = "Health {Canada/BIOTECanada} Summit on regulatory and clinical
             topics related to subsequent entry biologics (biosimilars),
             Ottawa, Canada, 14 May 2012",
  author  = "Kay, Jonathan and Feagan, Brian G and Guirguis, Micheal S and
             Keystone, Edward C and Klein, Agnes V and Lubiniecki, Anthony S
             and Mould, Diane R and Nyarko, Kwasi A and Ridgway, Anthony A G
             and Trudeau, Maureen E and Wang, Jian",
  journal = "Biologicals",
  volume  =  40,
  number  =  6,
  pages   = "517--527",
  month   =  nov,
  year    =  2012
}

@ARTICLE{Parikh2012-tm,
  title   = "Vedolizumab for the treatment of active ulcerative colitis: a
             randomized controlled phase 2 dose-ranging study",
  author  = "Parikh, Asit and Leach, Timothy and Wyant, Tim and Scholz,
             Catherine and Sankoh, Serap and Mould, Diane R and Ponich, Terry
             and Fox, Irving and Feagan, Brian G",
  journal = "Inflamm. Bowel Dis.",
  volume  =  18,
  number  =  8,
  pages   = "1470--1479",
  month   =  aug,
  year    =  2012
}

@ARTICLE{Olivier2016-dq,
  title    = "Modeling and Simulation Tools: From Systems Biology to Systems
              Medicine",
  author   = "Olivier, Brett G and Swat, Maciej J and Mon{\'e}, Martijn J",
  journal  = "Methods Mol. Biol.",
  volume   =  1386,
  pages    = "441--463",
  year     =  2016,
  keywords = "Constraint-based modeling; Kinetic modeling; Pharmacodynamics;
              Pharmacometrics; Physiology-based pharmacokinetics; Quantitative
              and systems pharmacology; SBML; Software design; Standards
              development; Systems biology"
}

@ARTICLE{Riviere2015-tz,
  title    = "dfcomb: An R-package for phase {I/II} trials of drug combinations",
  author   = "Riviere, Marie-Karelle and Jourdan, Jacques-Henri and Zohar,
              Sarah",
  journal  = "Comput. Methods Programs Biomed.",
  month    =  nov,
  year     =  2015,
  keywords = "Adaptive design; Combination; Dose-finding; Phase I; R package"
}

@ARTICLE{Jodele2015-cb,
  title    = "Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring
              to Optimize Therapy for Thrombotic Microangiopathy after
              Hematopoietic Stem Cell Transplantation",
  author   = "Jodele, Sonata and Fukuda, Tsuyoshi and Mizuno, Kana and Vinks,
              Alexander A and Laskin, Benjamin L and Goebel, Jens and Dixon,
              Bradley P and Chima, Ranjit S and Hirsch, Russel and Teusink,
              Ashley and Lazear, Danielle and Lane, Adam and Myers, Kasiani C
              and Dandoy, Christopher E and Davies, Stella M",
  journal  = "Biol. Blood Marrow Transplant.",
  month    =  oct,
  year     =  2015,
  keywords = "CH50; Complement; Eculizumab; Membrane attack complex; Thrombotic
              microangiopathy; sC5b-9"
}

@ARTICLE{Zhang_undated-gg,
  title   = "Bayesian Model Assessment in Joint Modeling of Longitudinal and
             Survival Data with Applications to Cancer Clinical Trials",
  author  = "Zhang, Danjie and Chen, Ming-Hui and Ibrahim, Joseph G and Boye,
             Mark E and Shen, Wei",
  journal = "J. Comput. Graph. Stat.",
  volume  =  0,
  number  = "ja",
  pages   = "1--37"
}

@ARTICLE{Svensson2002-dn,
  title   = "Population pharmacokinetic and pharmacodynamic modelling of
             artemisinin and mefloquine enantiomers in patients with falciparum
             malaria",
  author  = "Svensson, Ulrika S H and Alin, Hassan and Karlsson, Mats O and
             Bergqvist, Yngve and Ashton, Michael",

license: MIT

license_type: permissive

branch_name: refs/heads/master

extension: bib