text:
Nervous System Diseases, Female, Middle Aged, Stereotyping},
date-added = {2010-02-18 23:29:53 +0100},
date-modified = {2010-07-29 19:48:29 +0200},
doi = {10.1007/s11136-009-9475-1},
pmid = {19396572},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Rao-2009-Qual%20Life%20Res_Measuring%20stigma%20acr.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5967},
rating = {0}
}

@book{Raudenbush:2002,
author = {S W Raudenbush and A S Bryk},
journal = {Book},
title = {Hierarchical linear models: Applications and data analysis method},
year = {2002},
date-added = {2010-01-03 19:37:35 +0100},
date-modified = {2010-07-29 19:21:41 +0200},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1112},
rating = {0}
}

@article{LeCao:2008p2587,
author = {Kim-Anh L{\^e} Cao and Debra Rossouw and Christ{\`e}le Robert-Grani{\'e} and Philippe Besse},
journal = {Statistical Applications in Genetics and Molecular Biology},
title = {A sparse PLS for variable selection when integrating omics data},
abstract = {Recent biotechnology advances allow for multiple types of omics data, such as transcriptomic, proteomic or metabolomic data sets to be integrated. The problem of feature selection has been addressed several times in the context of classification, but needs to be handled in a specific manner when integrating data. In this study, we focus on the integration of two-block data that are measured on the same samples. Our goal is to combine integration and simultaneous variable selection of the two data sets in a one-step procedure using a Partial Least Squares regression (PLS) variant to facilitate the biologists' interpretation. A novel computational methodology called ;;sparse PLS" is introduced for a predictive analysis to deal with these newly arisen problems. The sparsity of our approach is achieved with a Lasso penalization of the PLS loading vectors when computing the Singular Value Decomposition. Sparse PLS is shown to be effective and biologically meaningful. Comparisons with classical PLS are performed on a simulated data set and on real data sets. On one data set, a thorough biological interpretation of the obtained results is provided. We show that sparse PLS provides a valuable variable selection tool for highly dimensional data sets.},
affiliation = {INRA UR 631, Universit{\'e} de Toulouse. k.lecao@imb.uq.edu.au},
pages = {Article 35},
volume = {7},
year = {2008},
month = {Jan},
language = {eng},
keywords = {Toxicology, Animals, Multivariate Analysis, Saccharomyces cerevisiae, Least-Squares Analysis, Proteomics, Liver, Gene Expression Profiling, Rats, Biometry, Genomics, Data Interpretation: Statistical, Fermentation, Male, Metabolomics},
date-added = {2010-01-12 22:28:55 +0100},
date-modified = {2010-07-29 19:50:47 +0200},
doi = {10.2202/1544-6115.1390},
pmid = {19049491},
local-url = {file://localhost/Users/chl/Dropbox/Papers/L%C3%AA%20Cao-2008-Statistical%20Applications%20in%20Genetics%20and%20Molecular%20Biology_A%20sparse%20PLS%20for%20var.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2587},
rating = {0}
}

@article{Niculescu:2001p3052,
author = {A B Niculescu  and Hagop S Akiskal},
journal = {Mol Psychiatry},
title = {Proposed endophenotypes of dysthymia: evolutionary, clinical and pharmacogenomic considerations},
abstract = {Dysthymia is highly prevalent--though underdiagnosed--occurring in at least 3% of the population. We conceptualize it as the clinical extension of adaptive traits that have developed during evolution to cope with stress and failure. A classification of dysthymias into anxious and anergic subtypes--and their putative association to bipolarity--is proposed. We further posit neurochemical and neurophysiological substrates for the two subtypes. A better recognition and understanding of dysthymic subtypes and their respective place in the affective spectrum will increase the proportion of people that may benefit from targeted treatments. It would also expand the pool of subjects that may be enrolled in genetic and pharmacogenomic research studies.},
affiliation = {Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA, USA.},
number = {4},
pages = {363--6},
volume = {6},
year = {2001},
month = {Jul},
language = {eng},
keywords = {Phenotype, Humans, Dysthymic Disorder, Stress: Psychological, Adaptation: Psychological, Models: Psychological, Prevalence, Evolution, Anxiety, Models: Genetic},
date-added = {2010-01-14 11:26:02 +0100},
date-modified = {2010-07-29 20:18:17 +0200},
doi = {10.1038/sj.mp.4000906},
pmid = {11443518},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3052},
rating = {0}
}

@article{Meyer:2010p3689,
author = {D Meyer and F Leisch and T Hothorn and K Hornik},
title = {StatDataML: An XML Format for Statistical Data},
abstract = {In order to circumvent common difficulties in exchanging statistical data be- tween heterogeneous applications (format incompatibilities, technocentric data representation), we introduce a new data exchange format for statistical data called StatDataML. Because it seems natural for complex data structures to separate the raw data from its logical structure, we base StatDataML on XML, the Extendible Markup Language. In addition, our design borrows from the language S, such that data objects are basically organized as recursive and non-recursive structures, and may also be supplemented with meta-information. Besides a detailed presentation of the language elements, the paper includes a comparison with other data concepts as well as some examples illustrating the StatDataML format and its practical use.},
date-added = {2010-01-16 20:29:29 +0100},
date-modified = {2010-01-16 20:30:13 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Meyer--_StatDataML%20An%20XML%20F.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3689},
rating = {0}
}

@article{Polikar:2006p14258,
author = {R Polikar},
title = {Pattern Recognition},
year = {2006},
date-added = {2010-08-22 21:13:09 +0200},
date-modified = {2010-08-22 21:13:45 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Polikar-2006-_Pattern%20Recognition.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p14258},
rating = {3}
}

@article{Lam:2009p8329,
author = {Raymond W Lam and Erin E Michalak and Lakshmi N Yatham},
journal = {BMC Psychiatry},
title = {A new clinical rating scale for work absence and productivity: validation in patients with major depressive disorder},
abstract = {BACKGROUND: The prevalence of major depressive disorder (MDD) is highest in working age people and depression causes significant impairment in occupational functioning. Work productivity and work absence should be incorporated into clinical assessments but currently available scales may not be optimized for clinical use. This study seeks to validate the Lam Employment Absence and Productivity Scale (LEAPS), a 10-item self-report questionnaire that takes 3-5 minutes to complete. METHODS: The study sample consisted of consecutive patients attending a Mood Disorders outpatient clinic who were in full- or part-time paid work. All patients met DSM-IV criteria for MDD and completed during their intake assessment the LEAPS, the self-rated version of the Quick Inventory for Depressive Symptomatology (QIDS-SR), the Sheehan Disability Scale (SDS) and the Health and Work Performance Questionnaire (HPQ). Standard psychometric analyses for validation were conducted. RESULTS: A total of 234 patients with MDD completed the assessments. The LEAPS displayed excellent internal consistency as assessed by Cronbach's alpha of 0.89. External validity was assessed by comparing the LEAPS to the other clinical and work functioning scales. The LEAPS total score was significantly correlated with the SDS work disability score (r = 0.63, p < 0.01) and the Global Work Performance rating from the HPQ (r = -0.79, p < 0.01). The LEAPS total score also increased with greater depression severity. CONCLUSION: The LEAPS displays good internal and external validity in a population of patients with MDD attending an outpatient clinic, which suggests that it may be a clinically useful tool to assess and monitor work functioning and productivity in depressed patients.},
affiliation = {Department of Psychiatry, University of BC, Mood Disorders Centre, UBC Hospital, Vancouver, Canada. r.lam@ubc.ca},
pages = {78},
volume = {9},
year = {2009},
month = {Jan},
language = {eng},
keywords = {Male, Workload, Work, Personality Inventory, Absenteeism, Psychometrics, Work Capacity Evaluation, Questionnaires, Reproducibility of Results, Humans, Depressive Disorder: Major, Psychiatric Status Rating Scales, Cross-Sectional Studies, Efficiency, Adult, Diagnostic and Statistical Manual of Mental Disorders},
date-added = {2010-03-21 12:34:11 +0100},
date-modified = {2010-03-21 12:34:11 +0100},
doi = {10.1186/1471-244X-9-78},
pii = {1471-244X-9-78},
pmid = {19958540},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Lam-2009-BMC%20Psychiatry_A%20new%20clinical%20ratin.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8329},
rating = {0}
}

@article{Roju:1995,
author = {N S Roju and W J van der Linden and P F Fleer},
journal = {Applied Psychological Measurement},
title = {IRT-Based Internal Measures of Differential Functioning of Items and Tests},
pages = {353--368},
volume = {19},
year = {1995},
date-added = {2010-01-10 11:33:19 +0100},
date-modified = {2010-01-10 11:33:25 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Roju-1995-Applied%20Psychological%20Measurement_IRT-Based%20Internal%20M.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1946},
rating = {0}
}

@article{Liu:2007p12527,
author = {Xinhua Liu and Zhezhen Jin},
journal = {Stat Med},
title = {Item reduction in a scale for screening},
abstract = {This paper presents a non-parametric approach for the selection of items in a scale for screening, with the score defined as the sum of item response indicators. Without specifying parametric models for binary classification probabilities, the proposed item selection method evaluates the change in classification accuracy due to adding or deleting one item for a scale with k items. It first removes least useful items from the scale and then uses a forward stepwise selection procedure to the remaining items to identify a subset of items for a reduced scale. The reduced scale usually retains or improves classification accuracy compared to the full scale. The variation in items selected can be assessed with bootstrap samples. In a simulation study, the proposed procedure shows a fairly good finite sample performance. The method is illustrated with a data set on patients with and without high risk of developing Alzheimer's disease who were administered a 40-item test of olfactory function.},
affiliation = {Department of Biostatistics, Columbia University, New York, NY 10032, USA. XL26@columbia.edu},
number = {23},
pages = {4311--27},
volume = {26},
year = {2007},
month = {Oct},
language = {eng},
keywords = {Data Interpretation: Statistical, Mass Screening, United States, Risk Assessment, Humans, Alzheimer Disease},
date-added = {2010-06-15 17:41:28 +0200},
date-modified = {2010-06-15 17:41:32 +0200},
doi = {10.1002/sim.2853},
pmid = {17357995},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Liu-2007-Stat%20Med_Item%20reduction%20in%20a.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12527},
rating = {3}
}

@article{Fowler:2009p11437,
author = {Tom Fowler and Kate Langley and Frances Rice and Marianne B M van den Bree and Kenny Ross and Lawrence S Wilkinson and Michael J Owen and Michael C O'donovan and Anita Thapar},
journal = {Psychiatr Genet},
title = {Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity},
abstract = {OBJECTIVES: Psychopathy-related traits, especially those tapping the 'emotional dysfunction' aspect of psychopathy that is characterized by lack of emotional responsiveness, are thought to be of genetic origin, but molecular genetic studies are yet to be undertaken. Gene variants that affect COMT, MAOA and 5HTT activity have previously been linked to antisocial behaviour. The aims of this study were to test whether these gene variants are linked to psychopathy traits in attention-deficit hyperactivity disorder (ADHD). METHODS: Adolescents were followed up 5 years after an initial diagnosis of ADHD. Psychopathy trait scores were assessed [total scores and 'emotional dysfunction' (also referred to as 'affective') scores] and the MAOA 30-bp variable number of tandem repeats, SLC6A4 44-bp insertion/deletion and COMT Val158Met variants were genotyped. RESULTS: All three gene variants were associated with 'emotional dysfunction' scores. MAOA and 5HTT variants were associated with total psychopathy scores. The results were not explained by associated conduct disorder. CONCLUSION: The results suggest that specific gene variants influence psychopathy traits in ADHD.},
affiliation = {Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK.},
number = {6},
pages = {312--9},
volume = {19},
year = {2009},
month = {Dec},
language = {eng},
keywords = {Catechol O-Methyltransferase, Adolescent, Serotonin Plasma Membrane Transport Proteins, Humans, Attention Deficit Disorder with Hyperactivity, Genotype, Monoamine Oxidase},
date-added = {2010-05-01 17:19:17 +0200},
date-modified = {2010-05-01 17:19:17 +0200},
doi = {10.1097/YPG.0b013e3283328df4},
pmid = {19829167},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11437},
rating = {0}
}

@article{Lang:2005p2497,
author = {Undine E Lang and Rainer Hellweg and Peter Kalus and Malek Bajbouj and Kirsten P Lenzen and Thomas Sander and Dieter Kunz and J{\"u}rgen Gallinat},
journal = {Psychopharmacology (Berl)},
title = {Association of a functional BDNF polymorphism and anxiety-related personality traits},
abstract = {RATIONALE: Converging lines of evidence point to brain-derived neurotrophic factor (BDNF) as a factor in the pathophysiology of depression. Recently, it was shown that the Val allele of the BDNF Val66Met substitution polymorphism showed a significant association with higher mean neuroticism scores of the NEO-Five Factor Inventory (NEO-FFI) in healthy subjects, and previous studies suggested the Val allele to be increased in bipolar disorder families. The association to anxiety-related traits has not been investigated so far. METHODS: We tested a total of 343 unrelated subjects of German descent (171 male, 172 female, age: 39.0+/-14.6 years) who were carefully screened for psychiatric health. The self-ratable State-Trait Anxiety Inventory (STAI), which allows anxiety to be quantified as a comparatively stable personality trait, and the NEO-Five Factor Inventory (NEO-FFI) was applied. RESULTS: In the trait-related anxiety score, a significant (F=3.2, df=2, p<0.042) effect of the genotype was observed with higher levels of trait anxiety in Val/Val (35.0+/-7.4) compared to Val/Met (33.4+/-6.5) and Met/Met (32.0+/-4.6) genotypes. The NEO neuroticism scores were also higher in Val/Val (29.5+/-7.0) than in Val/Met (28.4+/-6.5) or Met/Met (26.8+/-5.8) genotype, but not at a significant rate. CONCLUSIONS: Our findings support the hypothesis that anxiety- and depression-related personality traits are associated with the BDNF polymorphism although the explained variance is low.},
affiliation = {Department of Neurology, University of Tuebingen, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany.},
number = {1},
pages = {95--9},
volume = {180},
year = {2005},
month = {Jun},
language = {eng},
keywords = {Anxiety Disorders, Female, Adult, Humans, Personality, Male, European Continental Ancestry Group, Psychiatric Status Rating Scales, Polymorphism: Single Nucleotide, Brain-Derived Neurotrophic Factor, Genotype},
date-added = {2010-01-12 13:34:17 +0100},
date-modified = {2010-01-12 13:34:17 +0100},
doi = {10.1007/s00213-004-2137-7},
pmid = {15918078},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Lang-2005-Psychopharmacology%20(Berl)_Association%20of%20a%20fun.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2497},
rating = {0}
}

@article{Rujescu:2007p10473,
author = {D Rujescu and E M Meisenzahl and S Krejcova and I Giegling and T Zetzsche and M Reiser and C M Born and H-J M{\"o}ller and A Veske and A Gal and U Finckh},
journal = {Mol Psychiatry},
title = {Plexin B3 is genetically associated with verbal performance and white matter volume in human brain},
abstract = {The presence of genetic influences on cognitive performance and brain volume is well established. However, specific genetic determinants of the variance of these quantitative traits are not yet known. Plexins act as receptors for semaphorins and are implicated in axon guidance, which is a key process in brain development. We have previously shown that plexin B3 is a highly potent stimulator of neurite outgrowth, which makes its gene PLXNB3 an intriguing candidate gene for traits related to human brain development and cerebral connectivity. We identified several polymorphisms in PLXNB3 predicting changes of amino acids (V598I, E1156D and V1596E) conserved at the corresponding positions of the orthologs in mouse and chimpanzee. PLXNB3 was genotyped in 303 healthy volunteers and 42 male patients with schizophrenia. Cognitive performance was measured with the vocabulary test (Wortschatztest (WST)), a method to estimate roughly general intelligence (g). Brain morphology was characterized by magnetic resonance imaging. Compared to subjects not carrying the modern, human-specific haplotype A, carriers of A scored higher in vocabulary test (WST) irrespective of diagnosis (P=0.0004). This effect could be observed in three independent groups (healthy males: P=0.048; schizophrenic males: P=0.034 and healthy females: P=0.037). Additionally, the haplotype A was associated with increased volume of brain white matter that in turn correlated with performance in the vocabulary test. These findings suggest that plexin B3 may influence cognitive performance, and the development of white matter in vivo in a way similar to its known stimulating effect on neurite outgrowth in vitro. These novel observations warrant further replication in independent samples.},
affiliation = {Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany. Dan.Rujescu@med.uni-muenchen.de},
number = {2},
pages = {190--4, 115},
volume = {12},
year = {2007},
month = {Feb},
language = {eng},
keywords = {Brain, Middle Aged, Haplotypes, Schizophrenia, Male, Aged, Cognition, Humans, Nerve Fibers: Myelinated, Linear Models, Neural Cell Adhesion Molecules, Cognition Disorders, Female, Verbal Learning, Nerve Tissue Proteins, Adult, Polymorphism: Single Nucleotide},
date-added = {2010-04-07 11:07:30 +0200},
date-modified = {2010-04-07 11:07:30 +0200},
doi = {10.1038/sj.mp.4001903},
pii = {4001903},
pmid = {17033634},
URL = {http://www.nature.com/mp/journal/v12/n2/abs/4001903a.html},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p10473},
rating = {0}
}

@article{Sonnenburg:2006p4877,
author = {S Sonnenburg and G R{\"a}tsch and C Sch{\"a}fer and B Sch{\"o}lkopf},
journal = {Journal of Machine Learning},
title = {Large Scale Multiple Kernel Learning},
abstract = {While classical kernel-based learning algorithms are based on a single kernel, in practice it is often desirable to use multiple kernels. Lanckriet et al. (2004) considered conic combinations of kernel matrices for classification, leading to a convex quadratically constrained quadratic program. We show that it can be rewritten as a semi-infinite linear program that can be efficiently solved by recy- cling the standard SVM implementations. Moreover, we generalize the formulation and our method to a larger class of problems, including regression and one-class classification. Experimental re- sults show that the proposed algorithm works for hundred thousands of examples or hundreds of kernels to be combined, and helps for automatic model selection, improving the interpretability of the learning result. In a second part we discuss general speed up mechanism for SVMs, especially when used with sparse feature maps as appear for string kernels, allowing us to train a string kernel SVM on a 10 million real-world splice data set from computational biology. We integrated multi- ple kernel learning in our machine learning toolbox SHOGUN for which the source code is publicly available at http://www.fml.tuebingen.mpg.de/raetsch/projects/shogun.},
pages = {1531--1565},
volume = {7},
year = {2006},
date-added = {2010-02-01 22:48:23 +0100},
date-modified = {2010-07-29 19:34:45 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Sonnenburg-2006-Journal%20of%20Machine%20Learning_Large%20Scale%20Multiple.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4877},
rating = {0}
}

@article{Gerber:2007p13186,
author = {Georg K Gerber and Robin D Dowell and Tommi S Jaakkola and David K Gifford},
journal = {PLoS Comput Biol},
title = {Automated discovery of functional generality of human gene expression programs},
abstract = {An important research problem in computational biology is the identification of expression programs, sets of co-expressed genes orchestrating normal or pathological processes, and the characterization of the functional breadth of these programs. The use of human expression data compendia for discovery of such programs presents several challenges including cellular inhomogeneity within samples, genetic and environmental variation across samples, uncertainty in the numbers of programs and sample populations, and temporal behavior. We developed GeneProgram, a new unsupervised computational framework based on Hierarchical Dirichlet Processes that addresses each of the above challenges. GeneProgram uses expression data to simultaneously organize tissues into groups and genes into overlapping programs with consistent temporal behavior, to produce maps of expression programs, which are sorted by generality scores that exploit the automatically learned groupings. Using synthetic and real gene expression data, we showed that GeneProgram outperformed several popular expression analysis methods. We applied GeneProgram to a compendium of 62 short time-series gene expression datasets exploring the responses of human cells to infectious agents and immune-modulating molecules. GeneProgram produced a map of 104 expression programs, a substantial number of which were significantly enriched for genes involved in key signaling pathways and/or bound by NF-kappaB transcription factors in genome-wide experiments. Further, GeneProgram discovered expression programs that appear to implicate surprising signaling pathways or receptor types in the response to infection, including Wnt signaling and neurotransmitter receptors. We believe the discovered map of expression programs involved in the response to infection will be useful for guiding future biological experiments; genes from programs with low generality scores might serve as new drug targets that exhibit minimal "cross-talk," and genes from high generality programs may maintain common physiological responses that go awry in disease states. Further, our method is multipurpose, and can be applied readily to novel compendia of biological data.},
affiliation = {Department of Computer Science and Electrical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.},
number = {8},
pages = {e148},
volume = {3},
year = {2007},
month = {Aug},
language = {eng},
keywords = {Signal Transduction, Software, Gene Expression, Computer Simulation, Gene Expression Profiling, Multigene Family, Proteome, Models: Biological, Algorithms, Pattern Recognition: Automated, Artificial Intelligence, Oligonucleotide Array Sequence Analysis},
date-added = {2010-06-26 11:21:01 +0200},
date-modified = {2010-07-29 19:43:29 +0200},
doi = {10.1371/journal.pcbi.0030148},
pii = {07-PLCB-RA-0047},
pmid = {17696603},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Gerber-2007-PLoS%20Comput%20Biol_Automated%20discovery.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13186},
read = {Yes},
rating = {0}
}

@inbook{Raiche:2002,
author = {Gilles Ra{\^\i}che and Jean-Guy Blais},
journal = {Book},
title = {Objective measurement, Theory into practice},
chapter = {{\'E}tude de la distribution d'{\'e}chantillonnage de l'estimateur du niveau d'habilet{\'e} en testing adaptatif en fonction de deux r{\`e}gles d'arr{\^e}t dans le contexte de l'application du mod{\`e}le de Rasch},
volume = {6},
year = {2002},
date-added = {2010-01-10 11:33:25 +0100},
date-modified = {2010-01-10 11:33:25 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Ra%C3%AEche-2002-Book_Objective%20measuremen.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2208},
rating = {0}
}

@article{Taphoorn:2010p11098,
author = {Martin J B Taphoorn and Lily Claassens and Neil K Aaronson and Corneel Coens and Murielle Mauer and David Osoba and Roger Stupp and Ren{\'e} O Mirimanoff and Martin J van den Bent and Andrew Bottomley and EORTC Quality of Life Group, and Brain Cancer, NCIC and Radiotherapy Groups},
journal = {Eur J Cancer},
title = {An international validation study of the EORTC brain cancer module (EORTC QLQ-BN20) for assessing health-related quality of life and symptoms in brain cancer patients},
abstract = {AIMS: The psychometric properties of the EORTC QLQ-BN20, a brain cancer-specific HRQOL questionnaire, have been previously determined in an English-speaking sample of patients. This study examined the validity and reliability of the questionnaire in a multi-national, multi-lingual study. METHODS: QLQ-BN20 data were selected from two completed phase III EORTC/NCIC clinical trials in brain cancer (N=891), including 12 languages. Experimental treatments were surgery followed by radiotherapy (RT) and adjuvant PCV chemotherapy or surgery followed by concomitant RT plus temozolomide (TMZ) chemotherapy and adjuvant TMZ chemotherapy. Standard treatment consisted of surgery and postoperative RT alone. The psychometrics of the QLQ-BN20 were examined by means of multi-trait scaling analyses, reliability estimation, known groups validity testing, and responsiveness analysis. RESULTS: All QLQ-BN20 items correlated more strongly with their own scale (r>0.70) than with other QLQ-BN20 scales. Internal consistency reliability coefficients were high (all alpha0.70). Known-groups comparisons yielded positive results, with the QLQ-BN20 distinguishing between patients with differing levels of performance status and mental functioning. Responsiveness of the questionnaire to changes over time was acceptable. CONCLUSION: The QLQ-BN20 demonstrates adequate psychometric properties and can be recommended for use in conjunction with the QLQ-C30 in assessing the HRQOL of brain cancer patients in international studies.},
affiliation = {Medical Centre Haaglanden, The Hague and VU University Medical Centre Amsterdam, The Netherlands. m.taphoorn@mchaaglanden.nl},
number = {6},
pages = {1033--40},
volume = {46},
year = {2010},
month = {Apr},
language = {eng},
date-added = {2010-04-14 13:52:35 +0200},
date-modified = {2010-07-29 20:13:56 +0200},
doi = {10.1016/j.ejca.2010.01.012},
pii = {S0959-8049(10)00031-6},
pmid = {20181476},
URL = {http://linkinghub.elsevier.com/retrieve/pii/S0959-8049(10)00031-6},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Taphoorn-2010-Eur%20J%20Cancer_An%20international%20val.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11098},
rating = {0}
}

@article{Saucier:2003p13850,
author = {G Saucier and L R Goldberg},
title = {The Structure of Personality attributes},
year = {2003},
date-added = {2010-07-29 17:41:42 +0200},
date-modified = {2010-07-29 17:42:18 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Saucier-2003-_The%20Structure%20of%20Per.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13850},
rating = {0}
}

@article{Debb:2007p11654,
author = {S M Debb},
journal = {The New School Psychology Bulletin},
title = {Cross-Cultural Awareness in Quality of Life Assessment},
abstract = {Since many tools for clinical assessment are available to practitioners of all medical and psychiatric fields, when a healthcare professional assesses the mental health of an individual, the use of culturally appropriate assessment measures used becomes increasingly important. Since many quality of life (QOL) assessment measures utilize Likert scaled questions, awareness and understanding of potential bias can greatly aid in clinical interpretation of scores, case conceptualization and treatment planning. Mental health professionals need to be cognizant of cultural issues and sensitive to the idea that the categorization of symptoms that our culture has clustered into disorders is dependent on specific cultural values (Draguns, 1987). Ultimately, cultural bias can greatly affect the validity and interpretability of assessment data. Modifications to assessment measures must also be considered in light of cross-cultural concerns, primarily as related to content validity.},
number = {2},
pages = {11--16},
volume = {5},
year = {2007},
date-added = {2010-05-11 22:49:26 +0200},
date-modified = {2010-07-29 19:52:59 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Debb-2007-The%20New%20School%20Psychology%20Bulletin_Cross-Cultural%20Aware.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11654},
rating = {0}
}

@article{Schafer:2002,
author = {J L Schafer and R M Yucel},
journal = {Journal of Computational and Graphical Statistics},
title = {Computational strategies for multivariate linear mixed-effects models with missing values},
number = {2},
pages = {437--457},
volume = {11},
year = {2002},
date-added = {2010-01-10 11:33:20 +0100},
date-modified = {2010-01-10 11:33:25 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Schafer-2002-Journal%20of%20Computational%20and%20Graphical%20Statistics_Computational%20strate-1.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2009},
rating = {0}
}

@article{Quene:2007p3552,
author = {H Quen{\'e}},
title = {Statistics with R},
abstract = {This workshop will introduce the R programming environment for statistical analysis. Contrary to SPSS which is procedure-oriented (commands are verbs, e.g. ``compute''), R is object-oriented (objects are nouns, e.g. ``factor''). In this workshop, we will try to ease the learning curve of using R for your data analysis. Experience with sta- tistical software is NOT required! We will use data simulation as well as real data sets, to explore topics like t-tests, chi-square tests, and lo- gistic regression. We will also show how R produces publication-quality figures. If time permits, we will also explore how to extend R with your own routines for analyzing and/or plotting data. You are encouraged to bring your own data set, if accompanied by a ``codebook'' file speci- fying variables (columns), data codes, etc. (Both files must be in plain ASCII).},
affiliation = {Utrecht institute of Linguistics OTS, Utrecht University},
year = {2007},
date-added = {2010-01-15 21:05:44 +0100},
date-modified = {2010-01-15 21:06:20 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Quen%C3%A9-2007-_Statistics%20with%20R.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3552},
rating = {0}
}

@article{Anderson:1994p11664,
author = {K J Anderson and W Revelle},
journal = {J Pers Soc Psychol},
title = {Impulsivity and Time of Day: Is Rate of Change in Arousal a Function of Impulsivity?},
abstract = {Impulsivity has been interpreted as a stable mediator of rate of change in arousal states. To test this hypothesis, 129 Ss differing in impulsivity were given placebo or caffeine at 9:00 a.m. or 7:30 p.m. Recognition memory was tested for the last 20 items from 2 lists of 24 items and 2 lists of 80 items. Scores from this paradigm reflect sustained attention and are thus sensitive to changes in arousal. A 4-way interaction among impulsivity, time of day, drug, and prior stimuli (p < .05) indicated that for those given placebo, recognition memory for long and late lists was poorer the higher the impulsivity in the morning; this pattern reversed in the evening. Caffeine reduced recognition errors. These results indicate that impulsivity is not a stable predictor of rate of change in arousal states. Instead, susceptibility to attentional lapses is mediated by impulsivity-related phase differences in diurnal arousal rhythms.},
number = {2},
pages = {334--344},
volume = {67},
year = {1994},
date-added = {2010-05-14 20:50:56 +0200},
date-modified = {2010-07-29 19:35:33 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Anderson-1994-J%20Pers%20Soc%20Psychol_Impulsivity%20and%20Time.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11664},
rating = {0}
}

@article{Kuhn:2008p12102,
author = {M Kuhn},
journal = {Journal of Statistical Software},
title = {Building Predictive Models in R Using the caret Package},
abstract = {The caret package, short for classification and regression training, contains numerous tools for developing predictive models using the rich set of models available in R. The package focuses on simplifying model training and tuning across a wide variety of modeling techniques. It also includes methods for pre-processing training data, calculating variable importance, and model visualizations. An example from computational chemistry is used to illustrate the functionality on a real data set and to benchmark the benefits of parallel processing with several types of models.},
number = {5},
volume = {28},
year = {2008},
date-added = {2010-05-25 23:28:37 +0200},
date-modified = {2010-05-25 23:29:21 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Kuhn-2008-Journal%20of%20Statistical%20Software_Building%20Predictive.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12102},
rating = {5}
}

@article{Stranger:2005p857,
author = {Barbara E Stranger and Matthew S Forrest and Andrew G Clark and Mark J Minichiello and Samuel Deutsch and Robert Lyle and Sarah Hunt and Brenda Kahl and Stylianos E Antonarakis and Simon Tavar{\'e} and Panagiotis Deloukas and Emmanouil T Dermitzakis},
journal = {PLoS Genet},
title = {Genome-wide associations of gene expression variation in humans},
abstract = {The exploration of quantitative variation in human populations has become one of the major priorities for medical genetics. The successful identification of variants that contribute to complex traits is highly dependent on reliable assays and genetic maps. We have performed a genome-wide quantitative trait analysis of 630 genes in 60 unrelated Utah residents with ancestry from Northern and Western Europe using the publicly available phase I data of the International HapMap project. The genes are located in regions of the human genome with elevated functional annotation and disease interest including the ENCODE regions spanning 1% of the genome, Chromosome 21 and Chromosome 20q12-13.2. We apply three different methods of multiple test correction, including Bonferroni, false discovery rate, and permutations. For the 374 expressed genes, we find many regions with statistically significant association of single nucleotide polymorphisms (SNPs) with expression variation in lymphoblastoid cell lines after correcting for multiple tests. Based on our analyses, the signal proximal (cis-) to the genes of interest is more abundant and more stable than distal and trans across statistical methodologies. Our results suggest that regulatory polymorphism is widespread in the human genome and show that the 5-kb (phase I) HapMap has sufficient density to enable linkage disequilibrium mapping in humans. Such studies will significantly enhance our ability to annotate the non-coding part of the genome and interpret functional variation. In addition, we demonstrate that the HapMap cell lines themselves may serve as a useful resource for quantitative measurements at the cellular level.},
affiliation = {Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom.},
number = {6},
pages = {e78},
volume = {1},
year = {2005},
month = {Dec},
language = {eng},
keywords = {Phenotype, Linkage (Genetics), Genetic Variation, Linkage Disequilibrium, Genome: Human, Humans, Models: Genetic, Genetic Techniques, Chromosome Mapping, Polymorphism: Single Nucleotide, Polymorphism: Genetic, Gene Expression Regulation},
date-added = {2010-01-03 17:48:55 +0100},
date-modified = {2010-01-03 17:48:55 +0100},
doi = {10.1371/journal.pgen.0010078},
pmid = {16362079},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Stranger-2005-PLoS%20Genet_Genome-wide%20associat.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p857},
read = {Yes},
rating = {0}
}

@article{Ip:2009p12899,
author = {E H Ip and D J M Smits and Paul De Boeck},
journal = {Applied Psychological Measurement},
title = {Locally Dependent Linear Logistic Test Model With Person Covariates},
abstract = {The article proposes a family of item-response models that allow the separate and independent specification of three orthogonal components: item attribute, person covariate, and local item dependence. Special interest lies in extending the linear logistic test model, which is commonly used to measure item attributes, to tests with embedded item clusters. The problem of local item dependence arises in item clusters. Existing methods for handling such dependence, how- ever, often fail to satisfy the property of invariant marginal interpretation of the item attribute parameters. Although such a property may not be necessary for applications that focus on pre- dictive analysis, it is critical for linear logistic test models. To achieve the marginal property, we implement an iterative estimation method, which is illustrated using data collected from an inventory on verbal aggressiveness.},
number = {7},
pages = {555--569},
volume = {33},
year = {2009},
date-added = {2010-06-24 14:00:14 +0200},
date-modified = {2010-07-29 20:46:12 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Ip-2009-Applied%20Psychological%20Measurement_Locally%20Dependent%20Li.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12899},
rating = {5}
}

@article{Spittle:2009p8350,
author = {Alicia J Spittle and Carmel Ferretti and Peter J Anderson and Jane Orton and Abbey Eeles and Lisa Bates and Roslyn N Boyd and Terrie E Inder and Lex W Doyle},
journal = {BMC Pediatr},
title = {Improving the outcome of infants born at <30 weeks' gestation--a randomized controlled trial of preventative care at home},
abstract = {ABSTRACT: BACKGROUND: Early developmental interventions to prevent the high rate of neurodevelopmental problems in very preterm children, including cognitive, motor and behavioral impairments, are urgently needed. These interventions should be multi-faceted and include modules for caregivers given their high rates of mental health problems. METHODS/DESIGN: We have designed a randomized controlled trial to assess the effectiveness of a preventative care program delivered at home over the first 12 months of life for infants born very preterm (<30 weeks of gestational age) and their families, compared with standard medical follow-up. The aim of the program, delivered over nine sessions by a team comprising a physiotherapist and psychologist, is to improve infant development (cognitive, motor and language), behavioral regulation, caregiver-child interactions and caregiver mental health at 24 months' corrected age. The infants will be stratified by severity of brain white matter injury (assessed by magnetic resonance imaging) at term equivalent age, and then randomized. At 12 months' corrected age interim outcome measures will include motor development assessed using the Alberta Infant Motor Scale and the Neurological Sensory Motor Developmental Assessment. Caregivers will also complete a questionnaire at this time to obtain information on behavior, parenting, caregiver mental health, and social support. The primary outcomes are at 24 months' corrected age and include cognitive, motor and language development assessed with the Bayley Scales of Infant and Toddler Development (Bayley-III). Secondary outcomes at 24 months include caregiver-child interaction measured using an observational task, and infant behavior, parenting, caregiver mental health and social support measured via standardized parental questionnaires. DISCUSSION: This paper presents the background, study design and protocol for a randomized controlled trial in very preterm infants utilizing a preventative care program in the first year after discharge home designed to improve cognitive, motor and behavioral outcomes of very preterm children and caregiver mental health at two-years' corrected age. CLINICAL TRIAL REGISTRATION NUMBER: ACTRN12605000492651.},
affiliation = {Physiotherapy, School of Health Sciences, University of Melbourne, 200 Berkley Street, Parkville, Victoria 3052, Australia. alicia.spittle@thewomens.org.au},
pages = {73},
volume = {9},
year = {2009},
month = {Jan},
language = {eng},
keywords = {Infant, Psychomotor Performance, Child Development, Prognosis, Home Care Services, Infant: Newborn, Cognition, Follow-Up Studies, Magnetic Resonance Imaging, Time Factors, Birth Weight, Humans, Cognition Disorders, Infant: Premature, Child: Preschool, Developmental Disabilities, Gestational Age, Infant Care},
date-added = {2010-03-21 12:52:11 +0100},
date-modified = {2010-03-21 12:52:11 +0100},
doi = {10.1186/1471-2431-9-73},
pii = {1471-2431-9-73},
pmid = {19954550},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Spittle-2009-BMC%20Pediatr_Improving%20the%20outcom.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8350},
rating = {0}
}

@article{Vacha-Haase:2001a,
author = {T Vacha-Haase and C R Tani and L R Kogan and R A Woodall and B Thompson},
journal = {Assessment},
title = {Reliability generalization: Exploring reliability variations on MMPI/MMPI-2 Validity scale scores},
pages = {391--401},
volume = {8},
year = {2001},
date-added = {2010-01-10 11:33:21 +0100},
date-modified = {2010-01-10 11:33:25 +0100},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1907},
rating = {0}
}

@techreport{Qian:2006,
author = {J Qian},
journal = {Techreport},
title = {Linking 2005 NAEP Science Assessments through Bridge Samples --How to design and analyze a trend assessment with context changes},
affiliation = {ETS},
year = {2006},
month = {Apr},
date-added = {2010-01-10 11:33:10 +0100},
date-modified = {2010-01-10 11:33:25 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Qian-2006-Techreport_Linking%202005%20NAEP%20Sc.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2113},
rating = {0}
}

@article{Tenenhaus:2009p4087,
author = {A Tenenhaus},
journal = {6th International Conference on Partial Least Squares and Related (PLS'09)},
title = {Kernel PLS path modelling},
abstract = {This paper deals with a kernel extension of a companion paper entitled ``new criterion based PLS path modeling approach to structural equation modeling'' [Tenenhaus, 2009] which will be presented during the PLS'09 conference.},
year = {2009},
date-added = {2010-01-19 20:01:23 +0100},
date-modified = {2010-01-19 20:02:02 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Tenenhaus-2009-6th%20International%20Conference%20on%20Partial%20Least%20Squares%20and%20Related%20(PLS'09)_Kernel%20PLS%20path%20mode.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4087},
rating = {0}
}

@article{Bradley:2006p4451,
author = {Clare Bradley},
journal = {Health Qual Life Outcomes},
title = {Feedback on the FDA's February 2006 draft guidance on Patient Reported Outcome (PRO) measures from a developer of PRO measures},
abstract = {I believe that the FDA guidelines have already had an impact in encouraging good practice in the use of PROs. There are, however, important improvements that need to be made to the guidelines, particularly in the use of health status and quality of life terminology. It is essential to distinguish between health status and quality of life and to use both terms. Nothing is to be gained and a great deal will be lost if the term quality of life (which has been misused as an umbrella term in the past) is abandoned and replaced with the term health status. Patients want us to consider their quality of life as well as their health. To abandon the term would be to forget about their quality of life and focus only on their health. Patients are well able to tell us what quality of life means to them and to rate the impact of a condition on their quality of life if we use individualised quality of life measures and individualised condition-specific quality of life measures to allow them to do so. Although my experience with PRO measures would support many of the recommendations in the guidelines there are others that I would not fully agree with or would contradict on the basis of my own research evidence. I have provided references to that research and hope that the FDA will feel able to do the same when they finalize their guidelines.},
affiliation = {Health Psychology Research, Royal Holloway, University of London, Egham, Surrey TW20 0EX, UK. c.bradley@rhul.ac.uk},
pages = {78},
volume = {4},
year = {2006},
month = {Jan},
language = {eng},
keywords = {Product Surveillance: Postmarketing, Self Concept, Quality of Life, Outcome Assessment (Health Care), Sickness Impact Profile, Practice Guidelines as Topic, United States, Humans, Attitude to Health, Psychometrics, United States Food and Drug Administration},
date-added = {2010-01-29 21:37:15 +0100},
date-modified = {2010-01-29 21:37:15 +0100},
doi = {10.1186/1477-7525-4-78},
pii = {1477-7525-4-78},
pmid = {17029628},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Bradley-2006-Health%20and%20Quality%20of%20Life%20Outcomes_Feedback%20on%20the%20FDA'.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4451},
rating = {0}
}

@article{Kaser:2007p11605,
author = {O Kaser and D Lemire},
title = {Tag-Cloud Drawing: Algorithms for Cloud Visualization},
abstract = {Tag clouds provide an aggregate of tag-usage statistics. They are typically sent as in-line HTML to browsers. However, display mechanisms suited for ordinary text are not ideal for tags, because font sizes may vary widely on a line. As well, the typical layout does not account for relationships that may be known between tags. This paper presents models and algorithms to improve the display of tag clouds that con- sist of in-line HTML, as well as algorithms that use nested tables to achieve a more general 2-dimensional layout in which tag relationships are considered. The first algorithms leverage prior work in typesetting and rectangle packing, whereas the second group of algorithms leverage prior work in Electronic Design Automation. Experiments show our algorithms can be efficiently implemented and perform well.},
year = {2007},
date-added = {2010-05-09 21:39:32 +0200},
date-modified = {2010-05-09 21:42:40 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Kaser-2007-_Tag-Cloud%20Drawing%20A.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11605},
rating = {0}
}

@article{Santor:2007p1831,
author = {Darcy A Santor and Haya Ascher-Svanum and Jean-Pierre Lindenmayer and Robert L Obenchain},
journal = {BMC Psychiatry},
title = {Item response analysis of the Positive and Negative Syndrome Scale},
abstract = {BACKGROUND: Statistical models based on item response theory were used to examine (a) the performance of individual Positive and Negative Syndrome Scale (PANSS) items and their options, (b) the effectiveness of various subscales to discriminate among individual differences in symptom severity, and (c) the appropriateness of cutoff scores recently recommended by Andreasen and her colleagues (2005) to establish symptom remission. METHODS: Option characteristic curves were estimated using a nonparametric item response model to examine the probability of endorsing each of 7 options within each of 30 PANSS items as a function of standardized, overall symptom severity. Our data were baseline PANSS scores from 9205 patients with schizophrenia or schizoaffective disorder who were enrolled between 1995 and 2003 in either a large, naturalistic, observational study or else in 1 of 12 randomized, double-blind, clinical trials comparing olanzapine to other antipsychotic drugs. RESULTS: Our analyses show that the majority of items forming the Positive and Negative subscales of the PANSS perform very well. We also identified key areas for improvement or revision in items and options within the General Psychopathology subscale. The Positive and Negative subscale scores are not only more discriminating of individual differences in symptom severity than the General Psychopathology subscale score, but are also more efficient on average than the 30-item total score. Of the 8 items recently recommended to establish symptom remission, 1 performed markedly different from the 7 others and should either be deleted or rescored requiring that patients achieve a lower score of 2 (rather than 3) to signal remission. CONCLUSION: This first item response analysis of the PANSS supports its sound psychometric properties; most PANSS items were either very good or good at assessing overall severity of illness. These analyses did identify some items which might be further improved for measuring individual severity differences or for defining remission thresholds. Findings also suggest that the Positive and Negative subscales are more sensitive to change than the PANSS total score and, thus, may constitute a "mini PANSS" that may be more reliable, require shorter administration and training time, and possibly reduce sample sizes needed for future research.},
affiliation = {School of Psychology, University of Ottawa, Ottawa, Canada, and The Provincial Centre of Excellence for Child and Youth Mental Health, Ottawa, Ontario, Canada. dsantor@uottawa.ca},
pages = {66},
volume = {7},
year = {2007},
month = {Jan},
language = {eng},
keywords = {Double-Blind Method, Schizophrenia, Individuality, Psychotic Disorders, Dyskinesias, Psychiatric Status Rating Scales, Adult, Benzodiazepines, Delusions, Models: Statistical, Personality Inventory, Defense Mechanisms, Depression, Female, Hallucinations, Reproducibility of Results, Middle Aged, Psychometrics, Treatment Outcome, Randomized Controlled Trials as Topic, Schizophrenic Psychology, Antipsychotic Agents, Male, Statistics: Nonparametric, Humans},
date-added = {2010-01-09 23:00:24 +0100},
date-modified = {2010-01-09 23:00:24 +0100},
doi = {10.1186/1471-244X-7-66},
pii = {1471-244X-7-66},
pmid = {18005449},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Santor-2007-BMC%20Psychiatry_Item%20response%20analys.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1831},
rating = {0}
}

@article{Tosteson:2003p6974,
author = {Tor D Tosteson and Jeffrey S Buzas and Eugene Demidenko and Margaret Karagas},
journal = {Stat Med},
title = {Power and sample size calculations for generalized regression models with covariate measurement error},
abstract = {Covariate measurement error is often a feature of scientific data used for regression modelling. The consequences of such errors include a loss of power of tests of significance for the regression parameters corresponding to the true covariates. Power and sample size calculations that ignore covariate measurement error tend to overestimate power and underestimate the actual sample size required to achieve a desired power. In this paper we derive a novel measurement error corrected power function for generalized linear models using a generalized score test based on quasi-likelihood methods. Our power function is flexible in that it is adaptable to designs with a discrete or continuous scalar covariate (exposure) that can be measured with or without error, allows for additional confounding variables and applies to a broad class of generalized regression and measurement error models. A program is described that provides sample size or power for a continuous exposure with a normal measurement error model and a single normal confounder variable in logistic regression. We demonstrate the improved properties of our power calculations with simulations and numerical studies. An example is given from an ongoing study of cancer and exposure to arsenic as measured by toenail concentrations and tap water samples.},
affiliation = {Dartmouth Medical School, Lebanon NH 03756, USA. tor.tosteson@dartmouth.edu},
number = {7},
pages = {1069--82},
volume = {22},
year = {2003},
month = {Apr},
language = {eng},
keywords = {Epidemiologic Research Design, Arsenic, Nails, Sample Size, Skin Neoplasms, Logistic Models, Humans, Water Supply, Urinary Bladder Neoplasms, Likelihood Functions, Bias (Epidemiology), Linear Models},
date-added = {2010-03-06 12:25:51 +0100},
date-modified = {2010-03-06 12:25:51 +0100},
doi = {10.1002/sim.1388},
pmid = {12652554},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Tosteson-2003-Stat%20Med_Power%20and%20sample%20siz.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6974},
rating = {0}
}

@article{Moinpour:2000p5970,
author = {C M Moinpour and B Lyons and S P Schmidt and K Chansky and R A Patchell},
journal = {Qual Life Res},
title = {Substituting proxy ratings for patient ratings in cancer clinical trials: an analysis based on a Southwest Oncology Group trial in patients with brain metastases},
abstract = {In studies of the effect of cancer treatment in the advanced disease setting, researchers have attempted to avoid missing data for quality of life (QOL) assessments by either substituting proxy for patient assessments from the outset or by interspersing proxy measures when patients are unable to respond. Although poor agreement between patient and proxy assessments has been amply demonstrated in the literature, interest in using proxy measures persists. Completion of the Spitzer QL-Index by a small sample of patients with brain metastases and family member proxies provided data for evaluating the ability to substitute proxy for patient QOL assessments. These data cannot address treatment efficacy due to the modest sample size. Rather, the analyses serve to alert researchers to the important distinction (in a clinical trial setting) between agreement and the use of the proxy as a surrogate. We present several methods for evaluating the accuracy of proxy measures and for identifying other sources of error and bias that may vary with time or with treatment arm. Lin's concordance correlation coefficient suggests that proxies are generally a poor substitute for capturing a patient's perspective of his/her QOL. A longitudinal analysis suggests that the use of proxy rather than patient responses could lead to different conclusions concerning radiation therapy's effect on QOL.},
affiliation = {Southwest Oncology Group Statistical Center, Seattle, WA, USA. carolm@swog.fhcrc.org},
number = {2},
pages = {219--31},
volume = {9},
year = {2000},
month = {Mar},
language = {eng},
keywords = {Psychometrics, Quality of Life, Least-Squares Analysis, Male, Reproducibility of Results, Longitudinal Studies, Proxy, Brain Neoplasms, Middle Aged, Clinical Trials as Topic, Adult, Questionnaires, Humans, Female, Aged},
date-added = {2010-02-18 23:30:28 +0100},
date-modified = {2010-07-29 19:48:29 +0200},
pmid = {10983485},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5970},
rating = {0}
}

@article{Lempert:2010p9622,
author = {Karolina M Lempert and Diego A Pizzagalli},
journal = {J Behav Ther Exp Psychiatry},
title = {Delay discounting and future-directed thinking in anhedonic individuals},
abstract = {Anhedonia (lack of reactivity to pleasurable stimuli) and a negatively skewed view of the future are important components of depression that could affect economic decisions in depressed individuals. Delay discounting paradigms might be useful for probing putative affective and cognitive underpinnings of such decisions. As a first step to evaluate whether difficulties experiencing pleasure might affect delay discounting, 36 undergraduate students with varying levels of anhedonia performed a delay discounting task in which they made choices between a small immediate and larger future monetary reward. Increasing levels of anhedonia (Snaith-Hamilton Pleasure Scale) were negatively associated with delay discounting rate, indicating that anhedonic individuals tended to choose the larger, albeit delayed reward. These correlations remained after controlling for variables previously linked to delay discounting (working memory capacity and impulsivity) and pessimistic future-directed thinking. The current findings provide preliminary evidence indicating that anhedonic individuals make less myopic decisions about their future, possibly due to their decreased responsiveness to immediate rewards.},
affiliation = {Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA.},
pages = {},
year = {2010},
month = {Feb},
language = {ENG},
date-added = {2010-03-25 14:40:36 +0100},
date-modified = {2010-07-29 19:32:03 +0200},
doi = {10.1016/j.jbtep.2010.02.003},
pii = {S0005-7916(10)00026-1},
pmid = {20219184},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Lempert-2010-J%20Behav%20Ther%20Exp%20Psychiatry_Delay%20discounting%20an.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p9622},
rating = {0}
}

@article{Schonlau:2002p12787,
author = {M Schonlau},
journal = {The Stata Joumal},
title = {The Clustergram: A graph for visualizing hierarchical and non-hierarchical cluster analyses},
abstract = {In hierarchical cluster analysis dendrogram graphs are used to visualize how clusters are formed. I propose an alternative graph named ``clustergram'' to examine how cluster members are assigned to clusters as the number of clusters increases. This graph is useful in exploratory analysis for non-hierarchical clustering algorithms like k-means and for hierarchical cluster algorithms when the number of observations is large enough to make dendrograms impractical. I present the Stata code and give two examples.},
pages = {316--327},
volume = {3},
year = {2002},
date-added = {2010-06-18 21:00:53 +0200},
date-modified = {2010-07-29 19:53:40 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Schonlau-2002-The%20Stata%20Joumal_The%20Clustergram%20A%20g.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12787},
rating = {0}
}

@article{Zhu:2008p14290,
author = {X Zhu},
title = {Semi-Supervised Learning Literature Survey},
year = {2008},
date-added = {2010-08-22 21:16:53 +0200},
date-modified = {2010-08-22 21:17:19 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Zhu-2008-_Semi-Supervised%20Lear.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p14290},
rating = {5}
}

@article{OKeeffe:2003p7940,
author = {Michael J O'Keeffe and Michael O'Callaghan and Gail M Williams and Jake M Najman and William Bor},
journal = {Pediatrics},
title = {Learning, cognitive, and attentional problems in adolescents born small for gestational age},
abstract = {OBJECTIVE: To determine whether the presence, severity, or symmetry of growth restriction in term infants is an independent risk factor for learning, cognitive, and attentional problems in adolescence. METHODS: A total of 7388 term infants have been followed prospectively since birth. At 14 years, 5059 mothers completed a Child Behavior Checklist and provided information on their child's school progress. A total of 5051 adolescents completed a Youth Self Report, with 3703 also undergoing psychometric testing with Ravens Progressive Matrices and Wide Range Achievement Test (WRAT) reading subtest. Outcomes were compared on the basis of birth weight groups and measures of body symmetry and were adjusted for the level of social risk at birth. RESULTS: Adolescents who were born small for gestational age (SGA), when compared with their appropriately grown counterparts (>10th percentile), were more likely to experience learning difficulties, with a higher prevalence in those of birth weight < or =3rd percentile. Girls of birth weight < or =3rd percentile were more likely to have attentional problems and low WRAT reading scores. There was no significant difference in Ravens IQ or mean WRAT reading scores between SGA and non-SGA groups. There was no association between body symmetry and any of the outcomes studied. CONCLUSIONS: SGA status seems to have only modest independent effects on learning, cognition, and attention in adolescence. Severity but not symmetry of growth restriction predicted learning difficulties.},
affiliation = {Department of Developmental Paediatrics, Mater Children's Hospital, Brisbane, Queensland, Australia.},
number = {2},
pages = {301--7},
volume = {112},
year = {2003},
month = {Aug},
language = {eng},
keywords = {Infant: Premature, Infant: Small for Gestational Age, Intelligence, Infant: Newborn, Adolescent Psychology, Questionnaires, Prospective Studies, Humans, Male, Attention Deficit Disorder with Hyperactivity, Female, Cognition Disorders, Adolescent, Learning Disorders},
date-added = {2010-03-20 19:27:12 +0100},
date-modified = {2010-03-20 19:27:12 +0100},
pmid = {12897278},
local-url = {file://localhost/Users/chl/Dropbox/Papers/O'Keeffe-2003-Pediatrics_Learning%20cognitive.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7940},
rating = {0}
}

@article{Benesteau:2007p6303,
author = {J B{\'e}nesteau},
journal = {Psychomotricit{\'e}},
title = {Manifestations des d{\'e}ficits neuro-d{\'e}veloppementaux de l'h{\'e}misph{\`e}re droit et troubles des communications non-verbales},
year = {2007},
date-added = {2010-02-20 20:16:19 +0100},
date-modified = {2010-02-20 20:16:58 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/B%C3%A9nesteau-2007-Psychomotricit%C3%A9_Manifestations%20des%20d.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6303},
rating = {0}
}

@article{Gao:2009p12944,
author = {J Gao and D B Hitchcok},
title = {James-Stein Shrinkage to Improve K-means Cluster Analysis},
abstract = {We study a general algorithm to improve accuracy in cluster anal- ysis that employs the James-Stein shrinkage effect in k-means cluster- ing. We shrink the centroids of clusters toward the overall mean of all data using a James-Stein-type adjustment, and then the James-Stein shrinkage estimators act as the new centroids in the next clustering iteration until convergence. We compare the shrinkage results to the traditional k-means method. Monte Carlo simulation shows that the magnitude of the improvement depends on the within-cluster vari- ance and especially on the effective dimension of the covariance ma- trix. Using the Rand index, we demonstrate that accuracy increases significantly in simulated data and in a real data example.},
year = {2009},
date-added = {2010-06-25 21:55:02 +0200},
date-modified = {2010-06-25 21:55:44 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Gao-2009-_James-Stein%20Shrinkag.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12944},
rating = {0}
}

@article{Lin:2010p13130,
author = {R F Lin and J J Chang and Y M Lu and M H Huang and Y J Lue},
journal = {Kaohsiung J Med Sci},
title = {Correlations between quality of life and psychological factors in patients with chronic neck pain},
abstract = {The purpose of this study was to investigate health-related quality of life (HRQOL) and associ- ated factors in patients with chronic neck pain (CNP). The HRQOL of patients with CNP was assessed by the Short Form-36 questionnaire in this cross-sectional study. To evaluate the psycho- logical factors related to HRQOL, the Eysenck Personality Questionnaire, Chinese Health Questionnaire, and Beck Anxiety Inventory were used. The scores for the eight subscales of Short Form-36 were all lower than the Taiwanese age-matched normative values (p < 0.001). The two most strongly affected subscales were the role--physical subscale and the bodily pain sub- scale; both scores were below half the score of the age-/sex-matched normative values. The phys- ical components summary score, a summary measure, was moderately correlated with age (r=--0.43), education level (r=0.37) and Beck Anxiety Inventory score (r=--0.36). The mental components summary score was moderately to highly correlated with the Chinese Health Questionnaire score (r=--0.72), the neuroticism domain of Eysenck Personality Questionnaire (r = --0.52) and Beck Anxiety Inventory score (r = --0.41). The HRQOL of patients with CNP was worse than that of normal subjects across all domains. Furthermore, patients with a neurotic per- sonality, minor psychiatric morbidity and higher anxiety status showed poor mental health, as measured by the Short Form-36. We found that patients with CNP had multiple physical and mental health problems in terms of. The mental health of patients with CNP was strongly associ- ated with various psychological factors. Comprehensive assessment of the physical and mental functioning of patients with CNP can improve the management and care of these patients.},
pages = {13--20},
volume = {26},
year = {2010},
date-added = {2010-06-26 10:56:29 +0200},
date-modified = {2010-06-26 10:57:47 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Lin-2010-Kaohsiung%20J%20Med%20Sci_Correlations%20between.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13130},
rating = {0}
}

@article{Das:2005,
author = {J Das and J S Hammer},
journal = {Journal of Development Economics},
title = {Which doctor? Combining vignettes and item response to measure clinical competence},
number = {2},
pages = {348--383},
volume = {78},
year = {2005},
date-added = {2010-01-03 19:38:21 +0100},
date-modified = {2010-01-03 19:38:22 +0100},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1178},
rating = {0}
}

@article{Newnham:2007p5373,
author = {Elizabeth A Newnham and Kate E Harwood and Andrew C Page},
journal = {J Affect Disord},
title = {Evaluating the clinical significance of responses by psychiatric inpatients to the mental health subscales of the SF-36},
abstract = {BACKGROUND: The Mental Health subscales of the Medical Outcomes Short Form Questionnaire (SF-36; [Ware, J.E., Snow, K.K., Kosinski, M., Gandek, B., 1993. SF-36 Health Survey: Manual and Interpretation Guide. Boston: The Health Institute, New England Medical Center]) are increasingly being used to evaluate treatment outcomes, but data to assess the clinical significance of changes are absent. The present study applied Jacobson and Truax's [Jacobson, N.S., Truax, P. 1991. Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. Journal of Consulting and Clinical Psychology 59, 12-19] criteria for clinical significance to the mental health items of the SF-36. METHOD: Admission and discharge data were collated from 1830 consecutive inpatients at a psychiatric hospital, using the SF-36, the Depression Anxiety Stress Scale, the Quality of Life Enjoyment and Satisfaction Questionnaire and the clinician-rated Health of the Nation Outcome Scale. RESULTS: Appropriate improvement cut-off scores for the mental health subscales of the SF-36 are reported, and significant differences were found between outcome groups according to clinically significant improvement. LIMITATIONS: Clinical significance as a means of assessing outcome should be used with caution in inpatient settings, as further improvement is often expected upon discharge from the hospital. CONCLUSIONS: Assessing clinically significant improvement is an effective means of measuring treatment outcome in terms of quality of life and symptom improvement in psychiatric care.},
affiliation = {School of Psychology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, Australia. newnhe01@student.uwa.edu.au},
number = {1-2},
pages = {91--7},
volume = {98},
year = {2007},
month = {Feb},
language = {eng},
keywords = {Health Surveys, Reference Values, Inpatients, Mental Disorders, Humans, Questionnaires, Reproducibility of Results, Hospitals: Private, Australia, Psychiatric Status Rating Scales, Psychotic Disorders, Hospitals: Psychiatric},
date-added = {2010-02-11 10:28:50 +0100},
date-modified = {2010-07-29 19:31:26 +0200},
doi = {10.1016/j.jad.2006.07.001},
pii = {S0165-0327(06)00295-3},
pmid = {16904752},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5373},
rating = {3}
}

@article{Albert:2004p12798,
author = {Paul S Albert and Lori E Dodd},
journal = {Biometrics},
title = {A cautionary note on the robustness of latent class models for estimating diagnostic error without a gold standard},
abstract = {Modeling diagnostic error without a gold standard has been an active area of biostatistical research. In a majority of the approaches, model-based estimates of sensitivity, specificity, and prevalence are derived from a latent class model in which the latent variable represents an individual's true unobserved disease status. For simplicity, initial approaches assumed that the diagnostic test results on the same subject were independent given the true disease status (i.e., the conditional independence assumption). More recently, various authors have proposed approaches for modeling the dependence structure between test results given true disease status. This note discusses a potential problem with these approaches. Namely, we show that when the conditional dependence between tests is misspecified, estimators of sensitivity, specificity, and prevalence can be biased. Importantly, we demonstrate that with small numbers of tests, likelihood comparisons and other model diagnostics may not be able to distinguish between models with different dependence structures. We present asymptotic results that show the generality of the problem. Further, data analysis and simulations demonstrate the practical implications of model misspecification. Finally, we present some guidelines about the use of these models for practitioners.},
affiliation = {Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA. Albertp@ctep.nci.nih.gov},
number = {2},
pages = {427--35},
volume = {60},
year = {2004},
month = {Jun},
language = {eng},
keywords = {Dental Caries, Humans, Biometry, Models: Statistical, Sensitivity and Specificity, Likelihood Functions, Diagnostic Errors},
date-added = {2010-06-18 21:21:27 +0200},
date-modified = {2010-07-29 20:18:34 +0200},
doi = {10.1111/j.0006-341X.2004.00187.x},
pii = {BIOM187},
pmid = {15180668},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Albert-2004-Biometrics_A%20cautionary%20note%20on.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12798},
rating = {0}
}

@article{Gandek:1998p12744,
author = {B Gandek and J E Ware},
journal = {Journal of Clinical Epidemiology},
title = {Methods for validating and norming translations of health status questionnaires: the IQOLA Project approach. International Quality of Life Assessment},
abstract = {This article briefly summarizes methods used in the empirical validation of translations of the SF-36 Health Survey. In addition, information about the IQOLA Project norming protocol and 13 general population norming samples analyzed in this supplement is provided.},
affiliation = {Health Assessment Lab at the Health Institute, New England Medical Center, Boston, Massachusetts 02111, USA.},
number = {11},
pages = {953--9},
volume = {51},
year = {1998},
month = {Nov},
language = {eng},
keywords = {Translations, Health Status Indicators, Quality of Life, Reference Values, Europe, Factor Analysis: Statistical, Humans, Data Collection, Questionnaires, Psychometrics, United States},
date-added = {2010-06-15 22:49:00 +0200},
date-modified = {2010-06-15 22:49:00 +0200},
pii = {S0895435698000869},
pmid = {9817112},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Gandek-1998-Journal%20of%20Clinical%20Epidemiology_Methods%20for%20validati.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12744},
rating = {0}
}

@article{Sugimura:2003p5609,
author = {Kazuhito Sugimura and Kent D Taylor and Ying-Chao Lin and Tieu Hang and Dai Wang and Yong-Ming Tang and Nathan Fischel-Ghodsian and Stephan R Targan and Jerome I Rotter and Huiying Yang},
journal = {Am J Hum Genet},
title = {A novel NOD2/CARD15 haplotype conferring risk for Crohn disease in Ashkenazi Jews},
abstract = {Crohn disease (CD) exhibits a 2-4-fold increased frequency in Jews as compared with other ethnic/racial groups. Three coding variants of the NOD2/CARD15 have been reported as independent disease-predisposing mutations (DPMs), but these were found in only 30%-40% of patients with CD and could not account for all the linkage between CD and the IBD1 locus. The aim of the present study was to explore whether additional DPMs at the IBD1 locus exist in the high-risk Jewish group. Sixty-four Ashkenazi Jewish and 147 non-Jewish white families were studied. Six microsatellite markers spanning IBD1 were genotyped for linkage analysis in subgroups stratified on NOD2/CARD15 DPM status. SNPs in NOD2/CARD15 (R702W, G908R, 1007fs, and S268P) were then genotyped in family and independent case-control samples. On the basis of initial results, sequencing was done on NOD2/CARD15-translated regions in 12 Jewish individuals. Subsequently, a new NOD2/CARD15 variant was genotyped and analyzed. After excluding the influence of the three DPMs, significant linkage of IBD1 to CD in Jews remained with two peaks at D16S403 (mean allele sharing [MAS] = 0.70] and D16S411 (MAS = 0.59). Further, we observed an increased frequency of a haplotype carrying only the 268S variant in Jewish patients (OR = 3.13, P=.0023) but not in non-Jews, suggesting the existence of a Jewish-specific additional disease-predisposing factor on this haplotype. Sequencing of this haplotype revealed a new variant (IVS8+158; JW1). The 268S-JW1 combination exhibited a further increased risk (OR = 5.75, P=.0005) and the highest population-attributable risk (15.1%) for CD among reported DPMs in Jews. In Ashkenazi Jews, unrecognized population-specific predisposing factor(s) exist on the 268S-JW1 haplotype at the IBD1 locus. This factor may contribute to the higher risk for CD in Ashkenazi Jews as compared with non-Jews.},
affiliation = {Division of Medical Genetics and Inflammatory Bowel Disease Research Center, Department of Medicine, Steven Spielberg Pediatric Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.},
number = {3},
pages = {509--18},
volume = {72},
year = {2003},
month = {Mar},
language = {eng},
keywords = {Intracellular Signaling Peptides and Proteins, Polymorphism: Single Nucleotide, European Continental Ancestry Group, Haplotypes, Amino Acid Substitution, Europe, Chromosome Mapping, Crohn Disease, Microsatellite Repeats, Humans, Base Sequence, Case-Control Studies, DNA Primers, Carrier Proteins, Phylogeny, Nod2 Signaling Adaptor Protein, Risk Factors, Genetic Predisposition to Disease, Jews},
date-added = {2010-02-12 15:46:49 +0100},
date-modified = {2010-02-12 15:46:49 +0100},
doi = {10.1086/367848},
pii = {S0002-9297(07)60567-9},
pmid = {12577202},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Sugimura-2003-Am%20J%20Hum%20Genet_A%20novel%20NOD2CARD15.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5609},
rating = {0}
}

@article{Chartier:2008p920,
author = {Sylvain Chartier and Andrew Faulkner},
journal = {Tutorial in Quantitative Methods for Psychology},
title = {General Linear Models: An Integrated Approach to Statistics},
abstract = {Generally, in psychology, the various statistical analyses are taught independently from each other. As a consequence, students struggle to learn new statistical analyses, in contexts that differ from their textbooks. This paper gives a short introduction to the general linear model (GLM), in which it is showed that ANOVA (one‐way, factorial, repeated	measure	and	analysis	of	covariance)	is	simply	a	multiple correlation/regression analysis (MCRA). Generalizations to other cases, such as multivariate and nonlinear analysis, are also discussed. It can easily be shown that every popular linear analysis can be derived from understanding MCRA.},
affiliation = {University of Ottawa},
number = {2},
pages = {65--78},
volume = {4},
year = {2008},
date-added = {2010-01-03 19:08:03 +0100},
date-modified = {2010-07-29 19:54:45 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Chartier-2008-Tutorial%20in%20Quantitative%20Methods%20for%20Psychology_General%20Linear%20Model.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p920},
rating = {0}
}

@article{Neelon:2010p12494,
author = {Brian Neelon and A James O'Malley and Sharon-Lise T Normand},
journal = {Biometrics},
title = {A Bayesian Two-Part Latent Class Model for Longitudinal Medical Expenditure Data: Assessing the Impact of Mental Health and Substance Abuse Parity},
abstract = {Summary. In 2001, the U.S. Office of Personnel Management required all health plans participating in the Federal Employees Health Benefits Program to offer mental health and substance abuse benefits on par with general medical benefits. The initial evaluation found that, on average, parity did not result in either large spending increases or increased service use over the four-year observational period. However, some groups of enrollees may have benefited from parity more than others. To address this question, we propose a Bayesian two-part latent class model to characterize the effect of parity on mental health use and expenditures. Within each class, we fit a two-part random effects model to separately model the probability of mental health or substance abuse use and mean spending trajectories among those having used services. The regression coefficients and random effect covariances vary across classes, thus permitting class-varying correlation structures between the two components of the model. Our analysis identified three classes of subjects: a group of low spenders that tended to be male, had relatively rare use of services, and decreased their spending pattern over time; a group of moderate spenders, primarily female, that had an increase in both use and mean spending after the introduction of parity; and a group of high spenders that tended to have chronic service use and constant spending patterns. By examining the joint 95% highest probability density regions of expected changes in use and spending for each class, we confirmed that parity had an impact only on the moderate spender class.},
affiliation = {Nicholas School of the Environment, Duke University, Durham, North Carolina 27708, U.S.A.},
pages = {},
year = {2010},
month = {May},
language = {ENG},
date-added = {2010-06-15 17:39:06 +0200},
date-modified = {2010-06-15 17:39:06 +0200},
doi = {10.1111/j.1541-0420.2010.01439.x},
pii = {BIOM1439},
pmid = {20528856},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Neelon-2010-Biometrics_A%20Bayesian%20Two-Part.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12494},
rating = {0}
}

@article{Punzo:2009p3281,
author = {A Punzo},
title = {Rasch model applied to the evaluation of didactics: nonparametric analysis of unidimensionality},
abstract = {In this study the Partial Credit Model is applied to a dataset arising from questionnaires on the evaluation of didactics. A nonparametric procedure to assess the unidimensionality assumption underlying this model is proposed and evaluated with
reference to this dataset.},
year = {2009},
date-added = {2010-01-14 21:12:52 +0100},
date-modified = {2010-01-14 21:13:49 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Punzo-2009-_Rasch%20model%20applied.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3281},
rating = {0}
}

@article{Bach:2006p1553,
author = {F R Bach and M I Jordan},
title = {A Probabilistic Interpretation of Canonical Correlation Analysis},
abstract = {We give a probabilistic interpretation of canonical correlation (CCA) analysis as a latent variable model for two Gaussian random vectors. Our interpretation is similar to the probabilistic interpretation of principal component analysis (Tipping and Bishop, 1999, Roweis, 1998). In addition, we can interpret Fisher linear discriminant analysis (LDA) as CCA between appropriately defined vectors.},
year = {2006},
date-added = {2010-01-07 16:38:27 +0100},
date-modified = {2010-01-07 16:39:07 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Bach-2006-_A%20Probabilistic%20Inte.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1553},
rating = {0}
}

@article{Krauth:2005p13815,
author = {J Krauth},
journal = {Psychology Science},
title = {Paradoxes in multidimensional contingency tables: What does this mean for CFA?},
abstract = {Lienert (1969, 1971a) justified his invention of Configural Frequency Analysis (CFA) by the ob- servation that higher-order interactions may exist in three- and higher-dimensional data even if no correlations between any pairs of variables can be observed. In Lienert (1971b) Hierarchical CFA (HCFA) was proposed in order to find that subset of variables which shows the highest degree of inter- dependence. In HCFA, the original contingency table is collapsed in a hierarchical way until two- dimensional tables result and CFA is applied to all tables in this hierarchy.
Now, it has been known for more than a hundred years that collapsing contingency tables may lead to strange results which are nowadays often denoted as Simpson's paradox (Simpson, 1951). Another paradox studied first by Lord (1967) occurs when groups are compared which may differ in their base- line values. Here, a contingency table version of this latter paradox is considered. Implications of these possible paradoxes for the interpretation of the results of CFA are discussed.},
number = {3/4},
pages = {304--314},
volume = {47},
year = {2005},
date-added = {2010-07-29 12:38:13 +0200},
date-modified = {2010-07-29 12:39:17 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Krauth-2005-Psychology%20Science_Paradoxes%20in%20multidi.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13815},
rating = {2}
}

@article{Hollen:2005p2865,
author = {P J Hollen and R J Gralla and M G Kris and S McCoy and G W Donaldson and C M Moinpour},
journal = {Qual Life Res},
title = {A comparison of visual analogue and numerical rating scale formats for the Lung Cancer Symptom Scale (LCSS): does format affect patient ratings of symptoms and quality of life?},
abstract = {PROBLEM AND PURPOSE: The Lung Cancer Symptom Scale (LCSS), a site-specific health-related quality of life measure for patients with lung cancer, was originally developed using a Visual Analogue Scale (VAS) format. However, the VAS format is not readily compatible with data management and software programs using scanning. The primary aim of this study was to evaluate the convergence of ratings obtained with a Numerical Rating Scale (NRS), with an 11-pt response category format, to those obtained with a VAS format. The intent was to determine the degree of agreement between two formats to generalize the existing psychometric properties for the original measure to the new presentation. DESIGN/SETTING: This methodological study evaluated the feasibility, reliability, and validity of a NRS format for the LCSS. The study was conducted at two cancer centers in New York City. PATIENTS/PROCEDURES: Sixty-eight patients with non-small cell lung cancer (NSCLC) completed both versions of the LCSS along with demographic and feasibility questions on a single occasion. The VAS form was administered first, followed by the NRS form to prevent bias. The intraclass correlation coefficient (ICC), Lin's concordance correlation coefficient (CCC), and Bland-Altman plots were used to evaluate agreement and to characterize bias. RESULTS: Cronbach's alpha for the NRS format total score was 0.89 for the 68 patients with NSCLC. Agreement was excellent, with both the ICC and CCC > or = 0.90 for the two summary scores (total score and average symptom burden index) for the LCSS. Only five of the nine individual items showed this level of strict agreement. An agreement criterion of > or = 0.80 (representing excellent) was observed for seven of the nine individual items (all but appetite loss and hemoptysis). Mean differences tended to be slightly lower for the VAS format compared to the NRS format (more so for the appetite and hemoptysis items), with evidence of scale shift for the same two items. The summary measures showed good concordance as measured by the ICC and CCC, but did display mean differences (VAS - NRS) of -2.7 and -3.1, respectively. CONCLUSIONS: Overall, the NRS format for the LCSS suitable for scanning has good feasibility, reliability (internal consistency), and convergent validity. The complete set of concordance evaluation measures supports the reproducibility of VAS scores by NRS scores, particularly for the two summary scores.},
affiliation = {School of Nursing, University of Virginia, Charlottesville, VA 22908-0782, USA. p.hollen@virginia.edu},
number = {3},
pages = {837--47},
volume = {14},
year = {2005},
month = {Apr},
language = {eng},
keywords = {Middle Aged, Pain Measurement, Reproducibility of Results, Aged, Severity of Illness Index, Lung Neoplasms, Female, Carcinoma: Non-Small-Cell Lung, Humans, Feasibility Studies, Quality of Life, Male, Adult, Aged: 80 and over},
date-added = {2010-01-13 14:57:56 +0100},
date-modified = {2010-07-29 19:48:28 +0200},
pmid = {16022076},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2865},
rating = {0}
}

@article{Capraro:2001,
author = {M M Capraro and R M Capraro and R K Henson},
journal = {Educational and Psychological Measurement},
title = {Measurement error of scores on the Mathematics Anxiety Rating Scale across studies.},
pages = {373--386},
volume = {61},
year = {2001},
date-added = {2010-01-10 11:33:21 +0100},
date-modified = {2010-01-10 11:33:25 +0100},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2083},
rating = {0}
}

@article{Pinto:2009p9651,
author = {Emmanuel Pinto and Jean Reggers and Philip Gorwood and Claudette Boni and Gabrielle Scantamburlo and William Pitchot and Marc Ansseau},
journal = {Alcohol},
title = {The TaqI A DRD2 polymorphism in type II alcohol dependence: a marker of age at onset or of a familial disease?},
abstract = {Cloninger's type II is a severe, early-onset, male-limited, and genetically influenced, impulsive form of alcoholism. Significant association has been reported between the A1 allele of the D2 dopamine receptor (DRD2) gene, substance misuse and personality traits of impulsivity and novelty seeking. We assessed the association between the TaqI A DRD2 gene polymorphism with Cloninger's typology and family history of alcohol abuse, which is thought to be more frequent in type II alcoholics. Fifty-one male alcohol-dependent patients were discriminated between type I and type II according to age at onset of alcohol-related problems and interviewed about family history of alcoholism. The associations between DRD2 (A1 or A2 alleles), family history, and typology were assessed by Pearson's chi-square test. Although typology was not associated with the studied polymorphism, a higher rate of general family history of alcohol abuse was still observed in type II patients (chi(2)(1)=4.53; P=.033). Furthermore, the A1 allele of the DRD2 was significantly associated with paternal history of alcoholism (chi(2)(1)=4.66; P=.031) and male, first-degree, collateral history of alcoholism (chi(2)(1)=4.40; P=.036). Age at onset of alcohol-related problems as main discriminator between type I and type II alcohol dependence does not seem to be associated by the TaqI A DRD2 polymorphism. However, the A1 allele of the DRD2 may be a marker of male familial alcoholism, which has been associated with type II alcohol dependence.},
affiliation = {Department of Psychiatry, University of Li{\`e}ge, CHU Sart Tilman B35, Li{\`e}ge, Belgium. epinto@chu.ulg.ac.be},
note = {genim},
number = {4},
pages = {271--5},
volume = {43},
year = {2009},
month = {Jun},
language = {eng},
keywords = {Genetic Predisposition to Disease, Alleles, Deoxyribonucleases: Type II Site-Specific, Adult, Middle Aged, Age of Onset, Male, Genetic Markers, Polymorphism: Genetic, Alcoholism, Humans, Receptors: Dopamine D2},
date-added = {2010-03-25 14:57:05 +0100},
date-modified = {2010-03-25 18:20:17 +0100},
doi = {10.1016/j.alcohol.2009.02.006},
pii = {S0741-8329(09)00036-6},
pmid = {19376678},
URL = {http://linkinghub.elsevier.com/retrieve/pii/S0741-8329(09)00036-6},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Pinto-2009-Alcohol_The%20TaqI%20A%20DRD2%20poly.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p9651},
rating = {0}
}

@article{Tibshirani:2008p12912,
author = {Robert Tibshirani and Pei Wang},
journal = {Biostatistics},
title = {Spatial smoothing and hot spot detection for CGH data using the fused lasso},
abstract = {We apply the "fused lasso" regression method of (TSRZ2004) to the problem of "hot- spot detection", in particular, detection of regions of gain or loss in comparative genomic hybridization (CGH) data. The fused lasso criterion leads to a convex optimization problem, and we provide a fast algorithm for its solution. Estimates of false-discovery rate are also provided. Our studies show that the new method generally outperforms competing methods for calling gains and losses in CGH data.},
affiliation = {Department of Health, Stanford University Stanford, CA 94305, USA. tibs@stat.stanford.edu},
number = {1},
pages = {18--29},
volume = {9},
year = {2008},
month = {Jan},
language = {eng},
keywords = {Brain Neoplasms, Female, Genome: Human, Computer Simulation, Gene Dosage, Humans, Algorithms, Nucleic Acid Hybridization, Glioblastoma, Oligonucleotide Array Sequence Analysis, Data Interpretation: Statistical, Breast Neoplasms},
date-added = {2010-06-24 17:42:54 +0200},
date-modified = {2010-06-24 17:42:57 +0200},
doi = {10.1093/biostatistics/kxm013},
pii = {kxm013},
pmid = {17513312},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Tibshirani-2008-Biostatistics_Spatial%20smoothing%20an.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12912},
rating = {4}
}

@article{Yang:2008p3814,
author = {Hsin-Chou Yang and Hsin-Yi Hsieh and Cathy S J Fann},
journal = {Genetics},
title = {Kernel-based association test},
abstract = {Association mapping (i.e., linkage disequilibrium mapping) is a powerful tool for positional cloning of disease genes. We propose a kernel-based association test (KBAT), which is a composite function of "P-values of single-locus association tests" and "kernel weights related to intermarker distances and/or linkage disequilibria." The KBAT is a general form of some current test statistics. This method can be applied to the study of candidate genes and can scan each chromosome using a moving average procedure. We evaluated the performance of the KBAT through simulation studies that considered evolutionary parameters, disease models, sample sizes, kernel functions, test statistics, window attributes, empirical P-value estimations, and genetic/physical maps. The results showed that the KBAT had a well-controlled false positive rate and high power compared to existing methods. In addition, the KBAT was also applied to analyze a genomewide data set from the Collaborative Study on the Genetics of Alcoholism. Important genes associated with alcoholism dependence were identified. In summary, the merits of the KBAT are multifold: the KBAT is robust against the inclusion of nuisance markers, is invariant to the map scale, and accommodates different types of genomic data, study designs, and study purposes. The proposed methods are packaged in the user-friendly software, KBAT, available at http://www.stat.sinica.edu.tw/hsinchou/genetics/association/KBAT.htm.},
affiliation = {Institute of Statistical Science, Academia Sinica, 128 Academia Rd., Sec. 2, Nankang, Taipei, Taiwan 115. hsinchou@stat.sinica.edu.tw},
number = {2},
pages = {1057--68},
volume = {179},
year = {2008},
month = {Jun},
language = {eng},
keywords = {Chromosome Mapping, Biometry, Cloning: Molecular, Sample Size, Models: Genetic, Polymorphism: Single Nucleotide, Humans, Software, Linkage Disequilibrium, Evolution, Alcoholism, Computer Simulation, Genetic Predisposition to Disease, Physical Chromosome Mapping},
date-added = {2010-01-16 21:01:29 +0100},
date-modified = {2010-01-16 21:01:29 +0100},
doi = {10.1534/genetics.107.084616},
pii = {179/2/1057},
pmid = {18558654},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3814},
rating = {0}
}

@article{Luo:2003p5442,
author = {Dasen Luo and Lee Anne Thompson and Douglas K Detterman},
journal = {Behav Genet},
title = {Phenotypic and behavioral genetic covariation between elemental cognitive components and scholastic measures},
abstract = {The study subjected nine elementary cognitive task variables from the Cognitive Assessment Tasks (CAT) and three scholastic measures from the Metropolitan Achievement Test (MAT) to phenotypic and behavioral genetic structural equation modeling based on data for 277 pairs of same sex monozygotic (MZ) and dizygotic (DZ) twins from the Western Reserve Twin Project. Phenotypic and behavioral genetic covariation between certain elemental cognitive components and scholastic performance was examined to determine (a) whether these elemental cognitive components contribute substantially to the variance of scholastic performance; (b) whether such contributions vary across different domains of school knowledge or from specific domains to a general aptitude; (c) the behavioral genetic composition of the elemental cognitive components and the scholastic variables; and (d) how the association between the cognitive components and scholastic performance is genetically and environmentally mediated. The results of the study showed that as much as 30% of the phenotypic variance of scholastic performance was accounted for by the CAT general factor, which was presumably related to mental speed. A mainly genetic covariation was found between the mental speed component and scholastic performance, although each of the two variables was strongly influenced by both heritability and common family environment. The magnitude and etiology of the covariation were largely invariant whether mental speed was related to a common scholastic aptitude or to individual achievement measures covering different knowledge domains. Taken in conjunction with previous findings that mental speed has a substantial genetic correlation with psychometric g, and psychometric g has a mostly genetic covariation with scholastic achievement, the findings of the present study seems to point to a more global picture; namely, there is a causal sequence that starts from mental speed as the explanatory factor for both psychometric g and scholastic performance, and the etiology of the causal link is chiefly genetic.},
affiliation = {Department of Psychology, Indiana University of Pennsylvania, Indiana, Pennsylvania 15705, USA. dluo@grove.iup.edu},
number = {3},
pages = {221--46},
volume = {33},
year = {2003},
month = {May},
language = {eng},
keywords = {Reading, Questionnaires, Educational Measurement, Twins: Dizygotic, Mathematics, Language, Decision Making, Reaction Time, Phenotype, Cognition, Twins: Monozygotic, Humans, Models: Genetic, Schools, Child},
date-added = {2010-02-12 08:15:05 +0100},
date-modified = {2010-07-29 20:09:06 +0200},
pmid = {12837014},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5442},
rating = {0}
}

@article{StierJarmer:2009p6358,
author = {Marita Stier-Jarmer and Alarcos Cieza and Michael Borchers and Gerold Stucki and World Health Organization},
journal = {Clin J Pain},
title = {How to apply the ICF and ICF core sets for low back pain},
abstract = {OBJECTIVE: To introduce the International Classification of Functioning, Disability and Health (ICF) as conceptual model and classification and the ICF Core Sets as a way to specify functioning for a specific health condition such as Low Back Pain, and to illustrate the application of the ICF and ICF Core Sets in the context of clinical practice, the planning and reporting of studies and the comparison of health status measures. METHODS: A decision-making and consensus process was performed to develop the ICF Core Sets for Low Back Pain, the linking procedure was applied as basis for the content comparison of health-status measures and the Rehab-Cycle was used to exemplify the application of the ICE and ICF Core Sets in clinical practice. RESULTS: Two different ICF Core Sets, namely, a comprehensive and a brief, are presented, three different health-status measures were linked to the ICF and compared and a case example of a patient with Low back Pain was described based on the Rehab-Cycle. DISCUSSION: The ICF is a promising new framework and classification to assess the impact of Low Back Pain. The ICF and practical tools, such as the ICF Core Sets for Low Back Pain, are useful for clinical practice, outcome and rehabilitation research, education, health statistics, and regulation.},
affiliation = {Department of Physical Medicine and Rehabilitation, Ludwig-Maximilians-University, Munich.},
number = {1},
pages = {29--38},
volume = {25},
year = {2009},
month = {Jan},
language = {eng},
keywords = {Humans, Low Back Pain, Health Status Indicators, Disability Evaluation, Reference Standards},
date-added = {2010-02-23 08:21:26 +0100},
date-modified = {2010-02-23 08:21:26 +0100},
doi = {10.1097/AJP.0b013e31817bcc78},
pii = {00002508-200901000-00005},
pmid = {19158543},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6358},
rating = {0}
}

@article{Pettiford:2007p9734,
author = {Jasmine Pettiford and Rachel V Kozink and Avery M Lutz and Scott H Kollins and Jed E Rose and F Joseph McClernon},
journal = {Addict Behav},
title = {Increases in impulsivity following smoking abstinence are related to baseline nicotine intake and boredom susceptibility},
abstract = {Trait impulsivity and response inhibition have been shown to be related to smoking behavior. One measure of response inhibition - antisaccade performance, or the ability to inhibit looking at a novel stimulus - has been shown to be worsened by smoking abstinence, improved by nicotine administration and predictive of smoking cessation outcomes. However, relations between antisaccade performance and measures of trait impulsivity have not been extensively evaluated in smokers. In the present study, twelve dependent smokers (n=12) completed an eye tracking task following smoking as usual and overnight abstinence; and they completed baseline measures of trait impulsivity, smoking history and provided biological samples. As expected, overnight abstinence significantly increased antisaccade errors (p<0.002) while having no effect on prosaccade performance. Abstinence-induced increases in antisaccade errors were positively correlated with baseline plasma cotinine and Sensation Seeking Scale Boredom Susceptibility, and negatively correlated with IQ. These results suggest that smoking abstinence significantly increases errors of response inhibition and that the magnitude of this increase is related to trait impulsivity and nicotine intake variables.},
affiliation = {Duke University Medical Center, Durham, NC 27707, United States.},
number = {10},
pages = {2351--7},
volume = {32},
year = {2007},
month = {Oct},
language = {eng},
keywords = {Saccades, Nicotine, Adult, Biological Markers, Male, Female, Smoking, Intelligence Tests, Impulsive Behavior, Cotinine, Humans, Boredom, Smoking Cessation, Psychological Tests},
date-added = {2010-03-25 15:16:06 +0100},
date-modified = {2010-07-29 19:12:35 +0200},
doi = {10.1016/j.addbeh.2007.02.004},
pii = {S0306-4603(07)00069-X},
pmid = {17399907},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Pettiford-2007-Addict%20Behav_Increases%20in%20impulsi.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p9734},
rating = {0}
}

@article{Erosheva:2007p6275,
author = {E A Erosheva and S E Fienberg and C Joutard},
journal = {The Annals of Applied Statistics},
title = {Describing disability through individual-level mixture models for multivariate binary data},
abstract = {Data on functional disability are of widespread policy interest in the United States, especially with respect to planning for Medicare and Social Security for a growing population of elderly adults. We consider an extract of functional disability data from the National Long Term Care Survey (NLTCS) and attempt to develop disability profiles using variations of the Grade of Membership (GoM) model. We first describe GoM as an individual-level mixture model that allows individuals to have partial membership in several mixture components simultaneously. We then prove the equivalence between individual-level and population-level mixture models, and use this property to develop a Markov Chain Monte Carlo algorithm for Bayesian estimation of the model. We use our approach to analyze functional disability data from the NLTCS.},
number = {2},
pages = {502--537},
volume = {1},
year = {2007},
date-added = {2010-02-20 17:32:46 +0100},
date-modified = {2010-02-20 17:34:42 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Erosheva-2007-The%20Annals%20of%20Applied%20Statistics_Describing%20disabilit.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6275},
rating = {0}
}

@article{Borroni:2007p13729,
author = {Barbara Borroni and Mario Grassi and Chiara Agosti and Barbara Paghera and Antonella Alberici and Monica Di Luca and Daniela Perani and Alessandro Padovani},
journal = {BMC Neurol},
title = {Latent profile analysis in frontotemporal lobar degeneration and related disorders: clinical presentation and SPECT functional correlates},
abstract = {BACKGROUND: Frontotemporal Lobar Degeneration (FTLD) thus recently renamed, refers to a spectrum of heterogeneous conditions. This same heterogeneity of presentation represents the major methodological limit for the correct evaluation of clinical designation and brain functional correlates. At present, no study has investigated clinical clusters due to specific cognitive and behavioural disturbances beyond current clinical criteria. The aim of this study was to identify clinical FTLD presentation, based on cognitive and behavioural profile, and to define their SPECT functional correlations. METHODS: Ninety-seven FTLD patients entered the study. A clinical evaluation and standardised assessment were preformed, as well as a brain SPECT perfusion imaging study. Latent Profile Analysis on clinical, neuropsychological, and behavioural data was performed. Voxel-basis analysis of SPECT data was computed. RESULTS: Three specific clusters were identified and named "pseudomanic behaviour" (LC1), "cognitive" (LC2), and "pseudodepressed behaviour" (LC3) endophenotypes. These endophenotypes showed a comparable hypoperfusion in left temporal lobe, but a specific pattern involving: medial and orbitobasal frontal cortex in LC1, subcortical brain region in LC2, and right dorsolateral frontal cortex and insula in LC3. CONCLUSION: These findings provide evidence that specific functional-cluster symptom relationship can be delineated in FTLD patients by a standardised assessment. The understanding of the different functional correlates of clinical presentations will hopefully lead to the possibility of individuating diagnostic and treatment algorithms.},
affiliation = {Center for Aging Brain and Dementia, Department of Neurology, University of Brescia, Brescia, Italy. bborroni@inwind.it},
pages = {9},
volume = {7},
year = {2007},
month = {Jan},
language = {eng},
keywords = {Diagnosis: Differential, Mental Disorders, Aged, Middle Aged, Cognition Disorders, Humans, Dementia, Female, Male, Tomography: Emission-Computed: Single-Photon},
date-added = {2010-07-24 11:25:16 +0200},
date-modified = {2010-07-24 11:25:16 +0200},
doi = {10.1186/1471-2377-7-9},
pii = {1471-2377-7-9},
pmid = {17506892},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Borroni-2007-BMC%20Neurol_Latent%20profile%20analy.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13729},
rating = {0}
}

@article{Friston:1995p12351,
author = {K J Friston and A P Holmes and K J Worsley and J-B Poline and C D Frith and R SJ Frackowiak},
journal = {Hum Brain Mapp},
title = {Statistical Parametric Maps in Functional Imaging: A General Linear Approach},
abstract = {Statistical parametric maps are spatially extended statistical processes that are used to test hypotheses about regionally specific effects in neuroimaging data. The most established sorts of statistical parametric maps (e.g., Friston et al. [1991]: J Cereb Blood Flow Metab 11:690-699; Worsley et al. 119921: J Cereb Blood Flow Metab 12:YOO-918) are based on linear models, for example ANCOVA, correlation coefficients and t tests. In the sense that these examples are all special cases of the general linear model it should be possible to implement them (and many others) within a unified framework. We present here a general approach that accommodates most forms of experimental layout and ensuing analysis (designed experiments with fixed effects for factors, covariates and interaction of factors). This approach brings together two well established bodies of theory (the general linear model and the theory of Gaussian fields) to provide a complete and simple framework for the analysis of imaging data.
The importance of this framework is twofold: (i) Conceptual and mathematical simplicity, in that the same small number of operational equations is used irrespective of the complexity of the experiment or nature of the statistical model and (ii) the generality of the framework provides for great latitude in experimental design and analysis.},
pages = {189--210},
volume = {2},
year = {1995},
date-added = {2010-06-12 10:24:30 +0200},
date-modified = {2010-06-12 10:25:45 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Friston-1995-Hum%20Brain%20Mapp_Statistical%20Parametr.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12351},
rating = {0}
}

@article{Holbert:2003p859,
author = {R L Holbert and M T Stephenson},
journal = {Journal of Broadcasting {\&} Electronic Media},
title = {The importance of indirect effects in media effects research: Testing for mediation in structural equation modeling},
number = {4},
pages = {556--572},
volume = {47},
year = {2003},
date-added = {2010-01-03 17:49:45 +0100},
date-modified = {2010-01-03 17:51:10 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Holbert-2003-Journal%20of%20Broadcasting%20&%20Electronic%20Media_The%20importance%20of%20in.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p859},
rating = {0}
}

@article{Friston:2005p2336,
author = {K J Friston and K E Stephan and T E Lund and A Morcom and S Kiebel},
journal = {Neuroimage},
title = {Mixed-effects and fMRI studies},
abstract = {This note concerns mixed-effect (MFX) analyses in multisession functional magnetic resonance imaging (fMRI) studies. It clarifies the relationship between mixed-effect analyses and the two-stage "summary statistics" procedure (Holmes, A.P., Friston, K.J., 1998. Generalisability, random effects and population inference. NeuroImage 7, S754) that has been adopted widely for analyses of fMRI data at the group level. We describe a simple procedure, based on restricted maximum likelihood (ReML) estimates of covariance components, that enables full mixed-effects analyses in the context of statistical parametric mapping. Using this procedure, we compare the results of a full mixed-effects analysis with those obtained from the simpler two-stage procedure and comment on the situations when the two approaches may give different results.},
affiliation = {The Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK.},
number = {1},
pages = {244--52},
volume = {24},
year = {2005},
month = {Jan},
language = {eng},
keywords = {Magnetic Resonance Imaging, Hemodynamics, Linear Models, Brain Mapping, Reproducibility of Results, Speech Perception, Humans, Image Processing: Computer-Assisted, Mathematical Computing, Evoked Potentials: Auditory, Brain},
date-added = {2010-01-10 13:26:01 +0100},
date-modified = {2010-01-10 13:26:01 +0100},
doi =

license: MIT

license_type: permissive

branch_name: refs/heads/master

extension: bib