text:
558},
	pages = {1712--1722},
	number = {8},
	journaltitle = {Journal of Pharmaceutical Sciences},
	author = {Musteata, Florin Marcel and Pawliszyn, Janusz and Qian, Mark G. and Wu, Jing-Tao and Miwa, Gerald T.},
	urldate = {2017-04-11},
	date = {2006-08},
	langid = {english},
	file = {Musteata et al. - 2006 - Determination of Drug Plasma Protein Binding by Solid Phase Microextraction[8766].pdf:C\:\\Users\\nazmula\\Zotero\\storage\\HGAVS8BG\\Musteata et al. - 2006 - Determination of Drug Plasma Protein Binding by Solid Phase Microextraction[8766].pdf:application/pdf}
}

@article{mallik_analysis_2010,
	title = {Analysis of drug–protein binding by ultrafast affinity chromatography using immobilized human serum albumin},
	volume = {1217},
	url = {http://www.sciencedirect.com/science/article/pii/S0021967310002311},
	pages = {2796--2803},
	number = {17},
	journaltitle = {Journal of Chromatography A},
	author = {Mallik, Rangan and Yoo, Michelle J. and Briscoe, Chad J. and Hage, David S.},
	urldate = {2017-04-11},
	date = {2010},
	file = {Rapid-Determination-of-Rate-Constants-and-Binding-Constants-for-Solution-Phase-Drug-Protein-Interactions-by-Ultrafast-Affinity-Chromatography.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\ER5NG6HB\\Rapid-Determination-of-Rate-Constants-and-Binding-Constants-for-Solution-Phase-Drug-Protein-Interactions-by-Ultrafast-Affinity-Chromatography.pdf:application/pdf}
}

@article{li_characterization_2015-1,
	title = {Characterization of plasma protein binding dissociation with online {SPE}-{HPLC}},
	volume = {5},
	issn = {2045-2322},
	url = {http://www.nature.com/articles/srep14866},
	doi = {10.1038/srep14866},
	pages = {14866},
	journaltitle = {Scientific Reports},
	author = {Li, Ping and Fan, Yiran and Wang, Yunlong and Lu, Yaxin and Yin, Zheng},
	urldate = {2017-04-11},
	date = {2015-10-13},
	file = {srep14866.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\TBXXTTMX\\srep14866.pdf:application/pdf}
}

@article{svennebring_connection_2016,
	title = {The connection Between Plasma Protein Binding and Acute Toxicity as Determined by the {LD} $_{\textrm{50}}$ Value: {PLASMA} {PROTEIN} {BINDING} {VERSUS} {LD} $_{\textrm{50}}$},
	volume = {77},
	issn = {02724391},
	url = {http://doi.wiley.com/10.1002/ddr.21286},
	doi = {10.1002/ddr.21286},
	shorttitle = {The connection Between Plasma Protein Binding and Acute Toxicity as Determined by the {LD} $_{\textrm{50}}$ Value},
	pages = {3--11},
	number = {1},
	journaltitle = {Drug Development Research},
	author = {Svennebring, Andreas},
	urldate = {2017-04-11},
	date = {2016-02},
	langid = {english},
	file = {TheconnectionBetweenPlasmaProteinBindingandAcuteTo[retrieved-2017-04-10][8734].pdf:C\:\\Users\\nazmula\\Zotero\\storage\\PT8TVZSG\\TheconnectionBetweenPlasmaProteinBindingandAcuteTo[retrieved-2017-04-10][8734].pdf:application/pdf}
}

@article{kragh-hansen_molecular_1981,
	title = {Molecular aspects of ligand binding to serum albumin.},
	volume = {33},
	issn = {0031-6997, 1521-0081},
	url = {http://pharmrev.aspetjournals.org/content/33/1/17},
	pages = {17--53},
	number = {1},
	journaltitle = {Pharmacological Reviews},
	shortjournal = {Pharmacol Rev},
	author = {Kragh-Hansen, U.},
	urldate = {2017-04-11},
	date = {1981-03-01},
	langid = {english},
	pmid = {7027277},
	file = {Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\EC2DFEZM\\Kragh-Hansen - 1981 - Molecular aspects of ligand binding to serum album.pdf:application/pdf;Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\GP3WDHDM\\17.html:text/html}
}

@article{cavalieri_effects_1981,
	title = {The effects of drugs on the distribution and metabolism of thyroid hormones.},
	volume = {33},
	issn = {0031-6997, 1521-0081},
	url = {http://pharmrev.aspetjournals.org/content/33/2/55},
	pages = {55--80},
	number = {2},
	journaltitle = {Pharmacological Reviews},
	shortjournal = {Pharmacol Rev},
	author = {Cavalieri, R. R. and Pitt-Rivers, R.},
	urldate = {2017-04-11},
	date = {1981-06-01},
	langid = {english},
	pmid = {6170997},
	file = {Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\FEVRV5EU\\Cavalieri and Pitt-Rivers - 1981 - The effects of drugs on the distribution and metab.pdf:application/pdf;Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\GW4F2CGH\\55.html:text/html}
}

@article{nilsson_bioanalytical_2013,
	title = {The bioanalytical challenge of determining unbound concentration and protein binding for drugs},
	volume = {5},
	issn = {1757-6180},
	url = {http://www.future-science.com/doi/abs/10.4155/bio.13.274},
	doi = {10.4155/bio.13.274},
	abstract = {Knowledge regarding unbound concentrations is of vital importance when exploring the {PK} and {PD} of a drug. The accurate and reproducible determination of plasma protein binding and unbound concentrations for a compound/drug is a serious challenge for the bioanalytical laboratory. When the drug is in equilibrium with the binding protein(s), this equilibrium will shift when physiological conditions are not met. Furthermore, the true unbound fraction/concentration is unknown, and there are numerous publications in the scientific literature reporting and discussing data that have been produced without sufficient control of the parameters influencing the equilibrium. In this Review, different parameters affecting the equilibrium and analysis are discussed, together with suggestions on how to control these parameters in order to produce as trustworthy results for unbound concentrations/fractions as possible.},
	pages = {3033--3050},
	number = {24},
	journaltitle = {Bioanalysis},
	shortjournal = {Bioanalysis},
	author = {Nilsson, Lars B},
	urldate = {2017-04-11},
	date = {2013-12-01},
	file = {Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\CQ3NX7JW\\Nilsson - 2013 - The bioanalytical challenge of determining unbound.pdf:application/pdf;Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\3FZ25UAW\\bio.13.html:text/html}
}

@article{endo_polyparameter_2011-1,
	title = {Polyparameter Linear Free Energy Models for Polyacrylate Fiber−Water Partition Coefficients to Evaluate the Efficiency of Solid-Phase Microextraction},
	volume = {83},
	issn = {0003-2700},
	url = {http://dx.doi.org/10.1021/ac102868e},
	doi = {10.1021/ac102868e},
	abstract = {The fiber−water partition coefficient, Kfw, is decisive for performance of solid-phase microextraction ({SPME}) techniques in organic chemical analyses. In this study, polyacrylate ({PA})-coated fiber was evaluated for its Kfw values toward diverse neutral organic compounds. Literature Kfw data were thoroughly evaluated, and additional Kfw values for 69 compounds were measured in phosphate-buffered saline ({PBS}) solution at 37 °C. These Kfw data, spanning over 6 orders of magnitude, were used to construct polyparameter linear free energy relationship ({PP}-{LFER}) models. The {PP}-{LFER} models fit well to the data with a standard deviation of 0.15−0.23 log units. Additional experiments indicated that the differences in temperature (25 vs 37 °C), electrolyte concentrations (pure water vs {PBS}), and conditioning methods (heat vs methanol) had only minor influences ({\textless}0.3 log units) on Kfw. Using the established {PP}-{LFERs}, the {SPME} extraction efficiency of {PA} coating toward compounds of differing polarity was evaluated in comparison to poly(dimethylsiloxane) ({PDMS}) coating. {PA} exhibited higher extraction capacities for H-bond donor compounds (e.g., phenols, anilines, amides, and many drugs and pesticides) with the estimated Kfw values being 1−4 log units higher than those of {PDMS}. Also, {PA} was shown to be more efficient than {PDMS} for hydrophobic aromatic compounds.},
	pages = {1394--1400},
	number = {4},
	journaltitle = {Analytical Chemistry},
	shortjournal = {Anal. Chem.},
	author = {Endo, Satoshi and Droge, Steven T. J. and Goss, Kai-Uwe},
	urldate = {2017-04-11},
	date = {2011-02-15},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\E2WXQCJ2\\ac102868e.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\3T3MUX8X\\Endo et al. - 2011 - Polyparameter Linear Free Energy Models for Polyac.pdf:application/pdf}
}

@article{endo_equilibrium_2011,
	title = {Equilibrium Partition Coefficients of Diverse Polar and Nonpolar Organic Compounds to Polyoxymethylene ({POM}) Passive Sampling Devices},
	volume = {45},
	issn = {0013-936X},
	url = {http://dx.doi.org/10.1021/es202894k},
	doi = {10.1021/es202894k},
	abstract = {Equilibrium passive samplers ({EPS}) based on polyoxymethylene ({POM}) are increasingly used for determining freely dissolved water and pore water concentrations of hydrophobic organic compounds in the environment. Unlike other polymeric materials commonly used as {EPS}, namely poly(dimethylsiloxane) ({PDMS}) and low-density polyethylene ({PE}), {POM} is a polar polymer, containing repeating H-bond accepting ether units. Thus, {POM} is expected to be a more sensitive {EPS} than {PDMS} and {PE} for polar, H-bond donating compounds, such as many hormones, pharmaceuticals, and biocides. To better characterize the sorption capacity of {POM} for diverse polar and apolar compounds, equilibrium {POM}–water partition coefficients, {KPOM}/w, were measured for 56 compounds, including several classes of polar compounds and organochlorine pesticides. Using this data set and literature data, various {POM}-partitioning models were calibrated and validated for their ability to predict {KPOM}/w. The best performing models tested were an Abraham descriptor based polyparameter linear free energy relationship ({PP}-{LFER}) ({SD} = 0.24 log units) and {COSMOthermX} ({SD} = 0.37 log units). The performance of {SPARC} ({SD} = 0.61 log units) and log–log correlations with Kow ({SD} = 0.49 log units) were lower. A comparison with {PDMS} and {PE} confirmed expectations that {POM} exhibits a higher sensitivity for H-bond donating polar compounds than {PDMS} and {PE} do for these compounds. These findings expand the domain of chemicals for which {POM} can be used as an {EPS} sampler, and demonstrate that {POM} is as suitable a passive sampler for many polar organic compounds as it is for hydrophobic organic compounds.},
	pages = {10124--10132},
	number = {23},
	journaltitle = {Environmental Science \& Technology},
	shortjournal = {Environ. Sci. Technol.},
	author = {Endo, Satoshi and Hale, Sarah E. and Goss, Kai-Uwe and Arp, Hans Peter H.},
	urldate = {2017-04-11},
	date = {2011-12-01},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\2S94QEPM\\es202894k.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\NZU9QRE7\\Endo et al. - 2011 - Equilibrium Partition Coefficients of Diverse Pola.pdf:application/pdf}
}

@incollection{smith_defining_2016,
	location = {Berlin, Heidelberg},
	title = {Defining and Controlling Exposure During In Vitro Toxicity Testing and the Potential of Passive Dosing},
	url = {http://link.springer.com/10.1007/10_2015_5017},
	publisher = {Springer Berlin Heidelberg},
	author = {Smith, Kilian E.C. and Schäfer, Sabine},
	urldate = {2017-04-11},
	date = {2016},
	doi = {10.1007/10_2015_5017},
	file = {chp%3A10.1007%2F10_2015_5017.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\NVHGKXW6\\chp%3A10.1007%2F10_2015_5017.pdf:application/pdf}
}

@article{nabi_predicting_2017-1,
	title = {Predicting Partitioning and Diffusion Properties of Nonpolar Chemicals in Biotic Media and Passive Sampler Phases by {GC} × {GC}},
	volume = {51},
	issn = {0013-936X},
	url = {http://dx.doi.org/10.1021/acs.est.6b05071},
	doi = {10.1021/acs.est.6b05071},
	abstract = {The chemical parameters needed to explain and predict bioavailability, biodynamics, and baseline toxicity are not readily available for most nonpolar chemicals detected in the environment. Here, we demonstrate that comprehensive two-dimensional gas chromatography ({GC} × {GC}) retention times can be used to predict 26 relevant properties for nonpolar chemicals, specifically: partition coefficients for diverse biotic media and passive sampler phases; aquatic baseline toxicity; and relevant diffusion coefficients. The considered biotic and passive sampler phases include membrane and storage lipids, serum and muscle proteins, carbohydrates, algae, mussels, polydimethylsiloxane, polyethylene, polyoxymethylene, polyacrylate, polyurethane, and semipermeable membrane devices. {GC} × {GC}-based chemical property predictions are validated with a compilation of 1038 experimental property data collected from the literature. As an example application, we overlay a map of baseline toxicity to fathead minnows onto the separated analyte signal of a polychlorinated alkanes (chlorinated paraffins) technical mixture that contains 7820 congeners. In a second application, {GC} × {GC}-estimated properties are used to parametrize multiphase partitioning models for mammalian tissues and organs. In a third example, we estimate chemical depuration kinetics for mussels. Finally, we illustrate an approach to screen the {GC} × {GC} chromatogram for nonpolar chemicals of potentially high concern, defined based on their {GC} × {GC}-estimated biopartitioning properties, diffusion properties, and baseline toxicity.},
	pages = {3001--3011},
	number = {5},
	journaltitle = {Environmental Science \& Technology},
	shortjournal = {Environ. Sci. Technol.},
	author = {Nabi, Deedar and Arey, J. Samuel},
	urldate = {2017-04-11},
	date = {2017-03-07},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\7H2GAAAP\\acs.est.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\QMTUA8QI\\Nabi and Arey - 2017 - Predicting Partitioning and Diffusion Properties o.pdf:application/pdf}
}

@article{ma_development_2017,
	title = {Development and evaluation of predictive model for bovine serum albumin-water partition coefficients of neutral organic chemicals},
	volume = {138},
	issn = {0147-6513},
	url = {http://www.sciencedirect.com/science/article/pii/S0147651316305346},
	doi = {10.1016/j.ecoenv.2016.12.022},
	abstract = {The binding of organic chemicals to serum albumin can significantly reduce their unbound concentration in blood and affect their biological reactions. In this study, we developed a new {QSAR} model for bovine serum albumin ({BSA}) – water partition coefficients ({KBSA}/W) of neutral organic chemicals with large structural variance, {logKBSA}/W values covering 3.5 orders of magnitude (1.19–4.76). All chemical geometries were optimized by semi-empirical {PM}6 algorithm. Several quantum chemical parameters that reflect various intermolecular interactions as well as hydrophobicity were selected to develop {QSAR} model. The result indicates the regression model derived from {logKow}, the most positive net atomic charges on an atom, Connolly solvent excluded volume, polarizability, and Abraham acidity could explain the partitioning mechanism of organic chemicals between {BSA} and water. The simulated external validation and cross validation verifies the developed model has good statistical robustness and predictive ability, thus can be used to estimate the {logKBSA}/W values for chemicals in application domain, accordingly to provide basic data for the toxicity assessment of the chemicals.},
	pages = {92--97},
	journaltitle = {Ecotoxicology and Environmental Safety},
	shortjournal = {Ecotoxicology and Environmental Safety},
	author = {Ma, Guangcai and Yuan, Quan and Yu, Haiying and Lin, Hongjun and Chen, Jianrong and Hong, Huachang},
	urldate = {2017-04-11},
	date = {2017-04},
	keywords = {Bovine serum albumin – water partition coefficients, {PM}6, {QSAR}, Quantitative structure – property relationship, Quantum chemical descriptors},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\JNSS9B88\\S0147651316305346.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\9DGHBCGQ\\Ma et al. - 2017 - Development and evaluation of predictive model for.pdf:application/pdf}
}

@article{fischer_modeling_2017,
	title = {Modeling exposure in the Tox21 in vitro bioassays},
	issn = {0893-228X},
	url = {http://dx.doi.org/10.1021/acs.chemrestox.7b00023},
	doi = {10.1021/acs.chemrestox.7b00023},
	abstract = {High-throughput in vitro bioassays are becoming increasingly important in the risk characterization of anthropogenic chemicals. Large databases gather nominal effect concentrations (Cnom) for diverse modes of action. However, the biologically effective concentration can substantially deviate due to differences in chemical partitioning. In this study, we modeled freely dissolved (Cfree), cellular (Ccell), and membrane concentrations (Cmem) in the Tox21 {GeneBLAzer} bioassays for a set of neutral and ionogenic organic chemicals covering a large physicochemical space. Cells and medium constituents were experimentally characterized for their lipid and protein content and partition constants were collected from the literature or predicted by mechanistic models. The chemicals exhibited multifaceted partitioning to proteins and lipids with distribution ratios spanning over eight orders of magnitude. Modeled Cfree deviated over five orders of magnitude from Cnom, and can be compared to in vivo effect data, environmental concentrations and the unbound fraction in plasma, which is needed for the in vitro to in vivo extrapolation. Ccell was relatively constant for chemicals with membrane lipid-water distribution ratios of 1000 or higher and proportional to Cnom. Representing a sum parameter for exposure that integrates the entire dose from intracellular partitioning, Ccell is particularly suitable for the effect characterization of chemicals with multiple target sites and the calculation of their relative effect potencies. Effective membrane concentrations indicated that the specific effects of very hydrophobic chemicals in multiple bioassays are occurring at concentrations close to cytotoxicity. The equilibrium partitioning model including all relevant system parameters and a generic set-up is attached as an excel workbook to this paper and can readily be applied by everyone to diverse in vitro bioassays.},
	journaltitle = {Chemical Research in Toxicology},
	shortjournal = {Chem. Res. Toxicol.},
	author = {Fischer, Fabian Christoph and Henneberger, Luise and König, Maria and Bittermann, Kai and Linden, Lukas and Goss, Kai-Uwe and Escher, Beate I.},
	urldate = {2017-04-11},
	date = {2017-03-19},
	file = {ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\QBW7PD3E\\Fischer et al. - 2017 - Modeling exposure in the Tox21 in vitro bioassays.pdf:application/pdf;ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\8E9D3QXP\\acs.chemrestox.html:text/html}
}

@article{linden_3d-qsar_2017,
	title = {3D-{QSAR} predictions for bovine serum albumin–water partition coefficients of organic anions using quantum mechanically based descriptors},
	volume = {19},
	url = {http://pubs.rsc.org/en/Content/ArticleLanding/2017/EM/C6EM00555A},
	doi = {10.1039/C6EM00555A},
	pages = {261--269},
	number = {3},
	journaltitle = {Environmental Science: Processes \& Impacts},
	author = {Linden, Lukas and Goss, Kai-Uwe and Endo, Satoshi},
	urldate = {2017-04-11},
	date = {2017},
	langid = {english},
	file = {Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\UQ3ZX95P\\c6em00555a.html:text/html;Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\8MCR5M4E\\Linden et al. - 2017 - 3D-QSAR predictions for bovine serum albumin–water.pdf:application/pdf}
}

@article{henneberger_partitioning_2016,
	title = {Partitioning of Organic Ions to Muscle Protein: Experimental Data, Modeling, and Implications for in Vivo Distribution of Organic Ions},
	volume = {50},
	issn = {0013-936X},
	url = {http://dx.doi.org/10.1021/acs.est.6b01417},
	doi = {10.1021/acs.est.6b01417},
	shorttitle = {Partitioning of Organic Ions to Muscle Protein},
	abstract = {The in vivo partitioning behavior of ionogenic organic chemicals ({IOCs}) is of paramount importance for their toxicokinetics and bioaccumulation. Among other proteins, structural proteins including muscle proteins could be an important sorption phase for {IOCs}, because of their high quantity in the human and other animals’ body and their polar nature. Binding data for {IOCs} to structural proteins are, however, severely limited. Therefore, in this study muscle protein–water partition coefficients ({KMP}/w) of 51 systematically selected organic anions and cations were determined experimentally. A comparison of the measured {KMP}/w with bovine serum albumin ({BSA})–water partition coefficients showed that anionic chemicals sorb more strongly to {BSA} than to muscle protein (by up to 3.5 orders of magnitude), while cations sorb similarly to both proteins. Sorption isotherms of selected {IOCs} to muscle protein are linear (i.e., {KMP}/w is concentration independent), and {KMP}/w is only marginally influenced by {pH} value and salt concentration. Using the obtained data set of {KMP}/w a polyparameter linear free energy relationship ({PP}-{LFER}) model was established. The derived equation fits the data well (R2 = 0.89, {RMSE} = 0.29). Finally, it was demonstrated that the in vitro measured {KMP}/w values of this study have the potential to be used to evaluate tissue-plasma partitioning of {IOCs} in vivo.},
	pages = {7029--7036},
	number = {13},
	journaltitle = {Environmental Science \& Technology},
	shortjournal = {Environ. Sci. Technol.},
	author = {Henneberger, Luise and Goss, Kai-Uwe and Endo, Satoshi},
	urldate = {2017-04-11},
	date = {2016-07-05},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\2UWMBKZH\\acs.est.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\73H2K83B\\Henneberger et al. - 2016 - Partitioning of Organic Ions to Muscle Protein Ex.pdf:application/pdf}
}

@article{timmer_sorption_2017,
	title = {Sorption of Cationic Surfactants to Artificial Cell Membranes: Comparing Phospholipid Bilayers with Monolayer Coatings and Molecular Simulations},
	volume = {51},
	issn = {0013-936X},
	url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343551/},
	doi = {10.1021/acs.est.6b05662},
	shorttitle = {Sorption of Cationic Surfactants to Artificial Cell Membranes},
	abstract = {, This
study reports the distribution coefficient between phospholipid bilayer
membranes and phosphate buffered saline ({PBS}) medium ({DMW},{PBS}) for 19 cationic surfactants. The method used a
sorbent dilution series with solid supported lipid membranes ({SSLMs}).
The existing {SSLM} protocol, applying a 96 well plate setup, was adapted
to use 1.5 {mL} glass autosampler vials instead, which facilitated sampling
and circumvented several confounding loss processes for some of the
cationic surfactants. About 1\% of the phospholipids were found to
be detached from the {SSLM} beads, resulting in nonlinear sorption isotherms
for compounds with log {DMW} values above
4. Renewal of the medium resulted in linear sorption isotherms. {DMW} values determined at {pH} 5.4 demonstrated
that cationic surfactant species account for the observed {DMW},{PBS}. Log {DMW},{PBS} values above 5.5 are only experimentally feasible with lower {LC}-{MS}/{MS}
detection limits and/or concentrated extracts of the aqueous samples.
Based on the number of carbon atoms, dialkylamines showed a considerably
lower sorption affinity than linear alkylamine analogues. These {SSLM}
results closely overlapped with measurements on a chromatographic
tool based on immobilized artificial membranes ({IAM}-{HPLC}) and with
quantum-chemistry based calculations with {COSMOmic}. The {SSLM} data
suggest that {IAM}-{HPLC} underestimates the {DMW} of ionized primary and secondary alkylamines by 0.8 and 0.5 log
units, respectively.},
	pages = {2890--2898},
	number = {5},
	journaltitle = {Environmental Science \& Technology},
	shortjournal = {Environ Sci Technol},
	author = {Timmer, Niels and Droge, Steven T. J.},
	urldate = {2017-04-11},
	date = {2017-03-07},
	pmid = {28187261},
	pmcid = {PMC5343551},
	file = {PubMed Central Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\QKH52DTS\\Timmer and Droge - 2017 - Sorption of Cationic Surfactants to Artificial Cel.pdf:application/pdf}
}

@article{henneberger_equilibrium_2016,
	title = {Equilibrium Sorption of Structurally Diverse Organic Ions to Bovine Serum Albumin},
	volume = {50},
	issn = {0013-936X},
	url = {http://dx.doi.org/10.1021/acs.est.5b06176},
	doi = {10.1021/acs.est.5b06176},
	abstract = {Reliable partitioning data are essential for assessing the bioaccumulation potential and the toxicity of chemicals. In contrast to neutral organic chemicals, the partitioning behavior of ionogenic organic chemicals ({IOCs}) is still a black box for environmental scientists. Partitioning to serum albumin, the major protein in blood plasma, strongly influences the freely dissolved concentration of many chemicals (including {IOCs}), which affects their transport and distribution in the body. Because consistent data sets for partitioning of {IOCs} are rarely available, bovine serum albumin-water partition coefficients ({KBSA}/w) were measured in this study for 45 anionic and 4 cationic organic chemicals, including various substituted benzoic and naphthoic acids, sulfonates and several pesticides and pharmaceuticals. The results of this study suggest that binding to {BSA} is substantially influenced by the three-dimensional structure of the chemicals and the position of substitutions on the sorbing molecules. For example, we found a difference of {\textgreater}1.5 log units between isomeric chemicals such as 3,4-dichlorobenzoic acid and 2,6-dichlorobenzoic acid, and 1-naphthoic acid and 2-naphthoic acid. Conventional modeling approaches (e.g., based on octanol–water partition coefficients) poorly predict log {KBSA}/w of organic ions (R2 ≤ 0.5), partially because they do not capture the observed steric effects. Hence, alternative modeling strategies will be required for accurate prediction of serum albumin-water partition coefficients of organic ions.},
	pages = {5119--5126},
	number = {10},
	journaltitle = {Environmental Science \& Technology},
	shortjournal = {Environ. Sci. Technol.},
	author = {Henneberger, Luise and Goss, Kai-Uwe and Endo, Satoshi},
	urldate = {2017-04-11},
	date = {2016-05-17},
	keywords = {Balanced coverage paper},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\D3PDH4S5\\acs.est.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\NQZEMSJ9\\Henneberger et al. - 2016 - Equilibrium Sorption of Structurally Diverse Organ.pdf:application/pdf}
}

@article{bohm_sorption_2016,
	title = {Sorption of Highly Hydrophobic Organic Chemicals to Organic Matter Relevant for Fish Bioconcentration Studies},
	volume = {50},
	issn = {0013-936X},
	url = {http://dx.doi.org/10.1021/acs.est.6b01778},
	doi = {10.1021/acs.est.6b01778},
	abstract = {With regard to a potential underestimation of bioconcentration factors ({BCF}) in flow-through fish tests, sorption of 11 highly hydrophobic organic chemicals ({HOCs}) (log {KOW} 5.5–7.8) from different substance classes was systematically investigated for the first time in the presence of fish feed ({FF}) and filter residues ({FR}), the organic matter ({OM}) most relevant for fish bioconcentration studies. Sorption was investigated in batch-equilibrium experiments by solid-phase microextraction ({SPME}) resulting in partitioning coefficients of solid–water (Kd), total organic carbon–water ({KTOC}), and dissolved organic carbon–water ({KDOC}). Results prove a high affinity of {HOCs} for {FF} and {FR} supporting a significant impact on {BCF} studies and differing from sorption to Aldrich-humic acid ({AHA}) utilized as reference sorbent. Sorption is influenced by interactions between {HOCs} and {OM} characteristics. For {FF}, {KDOC} values were higher than {KTOC} values. Results help to assess the relevance of interaction of {HOCs} from different substance classes with {OM} relevant for {BCF} studies.},
	pages = {8316--8323},
	number = {15},
	journaltitle = {Environmental Science \& Technology},
	shortjournal = {Environ. Sci. Technol.},
	author = {Böhm, Leonard and Schlechtriem, Christian and Düring, Rolf-Alexander},
	urldate = {2017-04-11},
	date = {2016-08-02},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\WR57EB5E\\acs.est.pdf:application/pdf;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\428ZFWIB\\Böhm et al. - 2016 - Sorption of Highly Hydrophobic Organic Chemicals t.pdf:application/pdf}
}

@article{liu_mixture_2014,
	title = {Mixture Effects of Benzene, Toluene, Ethylbenzene, and Xylenes ({BTEX}) on Lung Carcinoma Cells via a Hanging Drop Air Exposure System},
	volume = {27},
	issn = {0893-228X},
	url = {http://dx.doi.org/10.1021/tx5000552},
	doi = {10.1021/tx5000552},
	abstract = {A recently developed hanging drop air exposure system for toxicity studies of volatile chemicals was applied to evaluate the cell viability of lung carcinoma A549 cells after 1 and 24 h of exposure to benzene, toluene, ethylbenzene, and xylenes ({BTEX}) as individual compounds and as mixtures of four or six components. The cellular chemical concentrations causing 50\% reduction of cell viability ({EC}50) were calculated using a mass balance model and came to 17, 12, 11, 9, 4, and 4 mmol/kg cell dry weight for benzene, toluene, ethylbenzene, m-xylene, o-xylene, and p-xylene, respectively, after 1 h of exposure. The {EC}50 decreased by a factor of 4 after 24 h of exposure. All mixture effects were best described by the mixture toxicity model of concentration addition, which is valid for chemicals with the same mode of action. Good agreement with the model predictions was found for benzene, toluene, ethylbenzene, and m-xylene at four different representative fixed concentration ratios after 1 h of exposure, but lower agreement with mixture prediction was obtained after 24 h of exposure. A recreated car exhaust mixture, which involved the contribution of the more toxic p-xylene and o-xylene, yielded an acceptable, but lower quality, prediction as well.},
	pages = {952--959},
	number = {6},
	journaltitle = {Chemical Research in Toxicology},
	shortjournal = {Chem. Res. Toxicol.},
	author = {Liu, Faye F. and Escher, Beate I. and Were, Stephen and Duffy, Lesley and Ng, Jack C.},
	urldate = {2017-04-11},
	date = {2014-06-16},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\K499SAD7\\tx5000552.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\FVWUSMWM\\Liu et al. - 2014 - Mixture Effects of Benzene, Toluene, Ethylbenzene,.pdf:application/pdf}
}

@article{endo_liposome_2013,
	title = {Liposome and protein–water partitioning of polybrominated diphenyl ethers ({PBDEs})},
	volume = {90},
	issn = {0045-6535},
	url = {http://www.sciencedirect.com/science/article/pii/S0045653512010442},
	doi = {10.1016/j.chemosphere.2012.07.069},
	abstract = {Bioaccumulation of polybrominated diphenyl ethers ({PBDEs}) in marine and terrestrial organisms is of great environmental concern. Understanding the partitioning of {PBDEs} to biological phases is crucial for elucidating their bioaccumulation behavior. In this study, partitioning coefficients of {PBDEs} from water to phospholipid liposomes (Klipw) and to bovine serum albumin ({BSA}) ({KBSAw}) were measured using a polymer depletion method. Klipw values measured in two laboratories are in an excellent agreement (within 0.14 log units), indicating a high method repeatability. The values of log Klipw and log {KBSAw} are in the range of 6.3–8.2 and 5.1–7.0, respectively, representing the highest of these partition coefficients measured to date. Log Klipw values for {PBDEs} are similar to the log of the octanol–water partition coefficients (Kow) (log Klipw − log Kow = −0.06 ± 0.23; mean ± {SD} of 7 congeners), consistent with the data of chlorobenzenes and polychlorinated biphenyls ({PCBs}) reported in the literature. No hydrophobicity cutoff was observed for partitioning to the liposome membrane. Log {KBSAw} values for {PBDEs} increase linearly with log Kow and do not follow the non-linear trend observed for polycyclic aromatic hydrocarbons ({PAHs}). This difference between {PBDEs} and {PAHs} suggests specific binding mechanisms to serum albumin even for hydrophobic compounds.},
	pages = {505--511},
	number = {2},
	journaltitle = {Chemosphere},
	shortjournal = {Chemosphere},
	author = {Endo, Satoshi and Mewburn, Ben and Escher, Beate I.},
	urldate = {2017-04-11},
	date = {2013-01},
	keywords = {Bioaccumulation, Brominated flame retardants, Membrane affinity, Polymer depletion, Serum albumin binding},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\T5DKEC5A\\S0045653512010442.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\PBJ9GP69\\Endo et al. - 2013 - Liposome and protein–water partitioning of polybro.pdf:application/pdf}
}

@article{gouliarmou_sorptive_2013,
	title = {Sorptive Physiologically Based Extraction of Contaminated Solid Matrices: Incorporating Silicone Rod As Absorption Sink for Hydrophobic Organic Contaminants},
	volume = {47},
	issn = {0013-936X},
	url = {http://dx.doi.org/10.1021/es303165u},
	doi = {10.1021/es303165u},
	shorttitle = {Sorptive Physiologically Based Extraction of Contaminated Solid Matrices},
	abstract = {The oral bioaccessibility of soil contaminants is increasingly assessed with physiologically based extraction tests ({PBETs}): the contaminant fraction that is desorbed into simulated digestive fluids is measured and classified as bioaccessible. However, this approach can lead to underestimations if the capacity of the fluids is insufficient to provide infinite sink conditions. Desorption will then progressively decrease and finally stop when equilibrium between soil and medium is reached. To circumvent this artifact, we incorporated a silicone rod as an absorption sink into the {PBET} to continuously absorb mobilized contaminants and maintain the desorption gradient. Polycyclic aromatic hydrocarbons served as model contaminants and the colon extended {PBET} as the extraction model. The inclusion of the silicone rod sink (1) increased the extraction capacity of the test by orders of magnitude, (2) ensured near infinite sink conditions, and (3) allowed for simple back-extraction of {PAHs} for their quantification by {GC}-{MS}. The silicone rod provided fast enrichment when applied to the stomach and small intestine compartment, but was somewhat slower in the richer colon compartment. Finally, the sorptive-{PBET} was applied to wood soot and a kindergarten soil. The present article provides the basis for how an absorption sink can be integrated into {PBET} models.},
	pages = {941--948},
	number = {2},
	journaltitle = {Environmental Science \& Technology},
	shortjournal = {Environ. Sci. Technol.},
	author = {Gouliarmou, Varvara and Collins, Chris D. and Christiansen, Ellen and Mayer, Philipp},
	urldate = {2017-04-11},
	date = {2013-01-15},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\SE37M62K\\es303165u.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\NKGTQ48Q\\Gouliarmou et al. - 2013 - Sorptive Physiologically Based Extraction of Conta.pdf:application/pdf}
}

@article{armitage_application_2014,
	title = {Application of Mass Balance Models and the Chemical Activity Concept To Facilitate the Use of in Vitro Toxicity Data for Risk Assessment},
	volume = {48},
	issn = {0013-936X},
	url = {http://dx.doi.org/10.1021/es501955g},
	doi = {10.1021/es501955g},
	abstract = {Practical, financial, and ethical considerations related to conducting extensive animal testing have resulted in various initiatives to promote and expand the use of in vitro testing data for chemical evaluations. Nominal concentrations in the aqueous phase corresponding to an effect (or biological activity) are commonly reported and used to characterize toxicity (or biological response). However, the true concentration in the aqueous phase can be substantially different from the nominal. To support in vitro test design and aid the interpretation of in vitro toxicity data, we developed a mass balance model that can be parametrized and applied to represent typical in vitro test systems. The model calculates the mass distribution, freely dissolved concentrations, and cell/tissue concentrations corresponding to the initial nominal concentration and experimental conditions specified by the user. Chemical activity, a metric which can be used to assess the potential for baseline toxicity to occur, is also calculated. The model is first applied to a set of hypothetical chemicals to illustrate the degree to which test conditions (e.g., presence or absence of serum) influence the distribution of the chemical in the test system. The model is then applied to set of 1194 real substances (predominantly from the {ToxCast} chemical database) to calculate the potential range of concentrations and chemical activities under assumed test conditions. The model demonstrates how both concentrations and chemical activities can vary by orders of magnitude for the same nominal concentration.},
	pages = {9770--9779},
	number = {16},
	journaltitle = {Environmental Science \& Technology},
	shortjournal = {Environ. Sci. Technol.},
	author = {Armitage, James M. and Wania, Frank and Arnot, Jon A.},
	urldate = {2017-04-11},
	date = {2014-08-19},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\WSRDVKGS\\es501955g.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\B66XME7A\\Armitage et al. - 2014 - Application of Mass Balance Models and the Chemica.pdf:application/pdf}
}

@article{endo_partitioning_2012,
	title = {Partitioning of Neutral Organic Compounds to Structural Proteins},
	volume = {46},
	issn = {0013-936X},
	url = {http://dx.doi.org/10.1021/es303379y},
	doi = {10.1021/es303379y},
	abstract = {Protein–water partition coefficients (Kpw) of neutral organic chemicals were measured using muscle proteins (from chicken, fish, and pig), collagen and gelatin. Kpw values for these structural proteins were consistently lower than those of bovine serum albumin ({BSA}), indicating that the use of {BSA} as a model protein leads to an overestimation of Kpw for structural proteins. Differences in Kpw between chicken, fish, and pig muscle proteins were small. Across the structural proteins, Kpw values were often in the order: muscle proteins {\textgreater} collagen ≥ gelatin. Differences in Kpw between the structural proteins were relatively large ({\textless}2 log units) for nonpolar compounds, and much smaller or insignificant for polar compounds. There were correlations between log Kpw of muscle proteins and log Kow (R2 = 0.83–0.86, {SD}: 0.35–0.40, n = 45–46). The polyparameter linear free energy relationship ({PP}-{LFER}) models fit even better to the data (R2 = 0.95, {SD}: 0.22). The good model fitting suggests that the reversible binding to muscle proteins can be considered to be nonspecific binding. There was an indication that some chemicals may sorb irreversibly to muscle proteins, which needs further research. We found that the partitioning to muscle protein is typically weaker than that to lipids, but that the protein partitioning of an H-bond donor compound can be as strong as the storage lipid partitioning.},
	pages = {12697--12703},
	number = {22},
	journaltitle = {Environmental Science \& Technology},
	shortjournal = {Environ. Sci. Technol.},
	author = {Endo, Satoshi and Bauerfeind, Jasmin and Goss, Kai-Uwe},
	urldate = {2017-04-11},
	date = {2012-11-20},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\5FJW5B7T\\es303379y.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\T9WMUWKK\\Endo et al. - 2012 - Partitioning of Neutral Organic Compounds to Struc.pdf:application/pdf}
}

@article{geisler_partitioning_2012,
	title = {Partitioning of Organic Chemicals to Storage Lipids: Elucidating the Dependence on Fatty Acid Composition and Temperature},
	volume = {46},
	issn = {0013-936X},
	url = {http://dx.doi.org/10.1021/es301921w},
	doi = {10.1021/es301921w},
	shorttitle = {Partitioning of Organic Chemicals to Storage Lipids},
	abstract = {Lipids serve as important compartments in partitioning of neutral organic chemicals into organisms. Storage lipids, made up of triglycerides with various fatty acids, are among the major classes of lipids. Here, we present experimental equilibrium partition data for diverse chemicals in fish oil, linseed oil, and goose fat at 37 °C. These data, in combination with data from the literature for olive oil and milk fat, show that the fatty acid composition of triglycerides has no significant influence on the partition coefficient. This result allows the derivation of a general predictive model for partitioning into storage lipids. We have collected storage lipid/water partition coefficients for 247 compounds to calibrate polyparameter linear free energy relationships (pp-{LFERs}) for 37 °C, which achieved a model fit with a root mean squared error of 0.20 log units. To extend the applicability of this model toward the aquatic food chain, we also measured fish oil partition data at 7 °C. The resulting enthalpies were used to calibrate an additional pp-{LFER} for the temperature dependence of storage lipid/water partitioning. This model allows us to estimate partition coefficients at desired temperatures that occur under typical ambient conditions.},
	pages = {9519--9524},
	number = {17},
	journaltitle = {Environmental Science \& Technology},
	shortjournal = {Environ. Sci. Technol.},
	author = {Geisler, Anett and Endo, Satoshi and Goss, Kai-Uwe},
	urldate = {2017-04-11},
	date = {2012-09-04},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\GZ9XQ7D9\\es301921w.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\RK2RJP64\\Geisler et al. - 2012 - Partitioning of Organic Chemicals to Storage Lipid.pdf:application/pdf}
}

@article{armitage_development_2013,
	title = {Development and evaluation of a mechanistic bioconcentration model for ionogenic organic chemicals in fish},
	volume = {32},
	issn = {1552-8618},
	url = {http://onlinelibrary.wiley.com/doi/10.1002/etc.2020/abstract},
	doi = {10.1002/etc.2020},
	abstract = {A mechanistic mass balance bioconcentration model is developed and parameterized for ionogenic organic chemicals ({IOCs}) in fish and evaluated against a compilation of empirical bioconcentration factors ({BCFs}). The model is subsequently applied to a set of perfluoroalkyl acids. Key aspects of model development include revised methods to estimate the chemical absorption efficiency of {IOCs} at the respiratory surface ({EW}) and the use of distribution ratios to characterize the overall sorption capacity of the organism. Membrane–water distribution ratios ({DMW}) are used to characterize sorption to phospholipids instead of only considering the octanol–water distribution ratio ({DOW}). Modeled {BCFs} are well correlated with the observations (e.g., r2 = 0.68 and 0.75 for organic acids and bases, respectively) and accurate to within a factor of three on average. Model prediction errors appear to be largely the result of uncertainties in the biotransformation rate constant ({kM}) estimates and the generic approaches for estimating sorption capacity (e.g., {DMW}). Model performance for the set of perfluoroalkyl acids considered is highly dependent on the input parameters describing hydrophobicity (i.e., log {KOW} of the neutral form). The model applications broadly support the hypothesis that phospholipids contribute substantially to the sorption capacity of fish, particularly for compounds that exhibit a high degree of ionization at biologically relevant {pH}. Additional empirical data on biotransformation and sorption to phospholipids and subsequent incorporation into property estimation approaches (e.g., {kM}, {DMW}) are priorities with respect to improving model performance. Environ. Toxicol. Chem. 2013;32:115–128. © 2012 {SETAC}},
	pages = {115--128},
	number = {1},
	journaltitle = {Environmental Toxicology and Chemistry},
	shortjournal = {Environmental Toxicology and Chemistry},
	author = {Armitage, James M. and Arnot, Jon A. and Wania, Frank and Mackay, Don},
	urldate = {2017-04-11},
	date = {2013-01-01},
	langid = {english},
	keywords = {Bioconcentration factor, Ionogenic organic chemicals, Mechanistic model, Perfluoroalkyl acids, Phospholipids},
	file = {Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\CTV9T6Q3\\abstract.html:text/html;Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\QBA42MX9\\Armitage et al. - 2013 - Development and evaluation of a mechanistic biocon.pdf:application/pdf}
}

@article{endo_serum_2011-1,
	title = {Serum Albumin Binding of Structurally Diverse Neutral Organic Compounds: Data and Models},
	volume = {24},
	issn = {0893-228X},
	url = {http://dx.doi.org/10.1021/tx200431b},
	doi = {10.1021/tx200431b},
	shorttitle = {Serum Albumin Binding of Structurally Diverse Neutral Organic Compounds},
	abstract = {Binding to serum albumin has a strong influence on freely dissolved, unbound concentrations of chemicals in vivo and in vitro. For neutral organic solutes, previous studies have suggested a log–log correlation between the albumin–water partition coefficient and the octanol–water partition coefficient (Kow) and postulated highly nonspecific binding that is mechanistically analogous to dissolution into solvents. These relationships and concepts were further explored in this study. Bovine serum albumin ({BSA})–water partition coefficients ({KBSA}/w) were measured for 83 structurally diverse neutral organic chemicals in consistent experimental conditions. The correlation between log {KBSA}/w and log Kow was moderate, with R2 = 0.76 and {SD} = 0.43. The log {KBSA}/w of low-polarity compounds including a series of chlorobenzenes and polycyclic aromatic hydrocarbons increased with log Kow linearly up to log Kow = 4–5, but then the linear relationship apparently broke off, and the increase became gradual. The fitting of polyparameter linear free energy relationship models with five solute descriptors was just comparable to that of the log Kow model (R2 = 0.78–0.79, {SD} = 0.41–0.42); the relatively high {SD} obtained suggests that solvent dissolution models are not capable of modeling albumin binding accurately. A size limitation of the binding site(s) of albumin is suggested as a possible reason for the high {SD}. An equilibrium distribution model indicates that serum albumin generally has high contributions to the binding in the serum of polar compounds and relatively small low-polarity compounds, whereas albumin binding for large low-polarity compounds is outcompeted by the strong partitioning into lipids due to low relative affinity of albumin for these compounds.},
	pages = {2293--2301},
	number = {12},
	journaltitle = {Chemical Research in Toxicology},
	shortjournal = {Chem. Res. Toxicol.},
	author = {Endo, Satoshi and Goss, Kai-Uwe},
	urldate = {2017-04-11},
	date = {2011-12-19},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\8957GJEJ\\tx200431b.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\76QVBFNB\\Endo and Goss - 2011 - Serum Albumin Binding of Structurally Diverse Neut.pdf:application/pdf}
}

@article{endo_capacities_2011,
	title = {Capacities of Membrane Lipids to Accumulate Neutral Organic Chemicals},
	volume = {45},
	issn = {0013-936X},
	url = {http://dx.doi.org/10.1021/es200855w},
	doi = {10.1021/es200855w},
	abstract = {Lipids have been considered as the predominant components for bioaccumulation of organic chemicals. However, differences in accumulation properties between different types of lipid (e.g., storage and membrane lipids) have rarely been considered. Moreover, in view of toxic effects on organisms, chemical accumulation specifically in biological membranes is of particular importance. In this review article, partition coefficients of 240 neutral organic compounds between liposomes (phospholipid membrane vesicles) and water (Klipw), reported in the literature or measured additionally for this work, were evaluated. Values of log Klipw and log Kow (octanol–water partition coefficients) differ by 0.4 on average. Polyparameter linear free energy relationships ({PP}-{LFERs}) can describe the log Klipw data even better (standard deviations = 0.28–0.31) than the log Kow model. Recent experimental data for highly hydrophobic compounds fit well to the {PP}-{LFERs} and do not indicate the existence of a previously postulated “hydrophobicity cutoff”. Predictive approaches based only on the molecular structure ({KOWWIN}, {SPARC}, {COSMOthermX}, {COSMOmic}) were also evaluated for Klipw prediction. The {PP}-{LFERs} revealed that partition coefficients into membrane lipids can be two log units higher than those into storage lipids for H-bond donor compounds, suggesting that distinguishing between the two lipids is necessary to account for the bioaccumulation of these compounds, and that tissues rich in membrane lipids (e.g., kidneys, liver) instead of fat tissue can be the primary phase for accumulation.},
	pages = {5912--5921},
	number = {14},
	journaltitle = {Environmental Science \& Technology},
	shortjournal = {Environ. Sci. Technol.},
	author = {Endo, Satoshi and Escher, Beate I. and Goss, Kai-Uwe},
	urldate = {2017-04-11},
	date = {2011-07-15},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\AQH925QK\\es200855w.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\SA96IMHX\\Endo et al. - 2011 - Capacities of Membrane Lipids to Accumulate Neutra.pdf:application/pdf}
}

@article{endo_polyparameter_2011-2,
	title = {Polyparameter Linear Free Energy Models for Polyacrylate Fiber−Water Partition Coefficients to Evaluate the Efficiency of Solid-Phase Microextraction},
	volume = {83},
	issn = {0003-2700},
	url = {http://dx.doi.org/10.1021/ac102868e},
	doi = {10.1021/ac102868e},
	abstract = {The fiber−water partition coefficient, Kfw, is decisive for performance of solid-phase microextraction ({SPME}) techniques in organic chemical analyses. In this study, polyacrylate ({PA})-coated fiber was evaluated for its Kfw values toward diverse neutral organic compounds. Literature Kfw data were thoroughly evaluated, and additional Kfw values for 69 compounds were measured in phosphate-buffered saline ({PBS}) solution at 37 °C. These Kfw data, spanning over 6 orders of magnitude, were used to construct polyparameter linear free energy relationship ({PP}-{LFER}) models. The {PP}-{LFER} models fit well to the data with a standard deviation of 0.15−0.23 log units. Additional experiments indicated that the differences in temperature (25 vs 37 °C), electrolyte concentrations (pure water vs {PBS}), and conditioning methods (heat vs methanol) had only minor influences ({\textless}0.3 log units) on Kfw. Using the established {PP}-{LFERs}, the {SPME} extraction efficiency of {PA} coating toward compounds of differing polarity was evaluated in comparison to poly(dimethylsiloxane) ({PDMS}) coating. {PA} exhibited higher extraction capacities for H-bond donor compounds (e.g., phenols, anilines, amides, and many drugs and pesticides) with the estimated Kfw values being 1−4 log units higher than those of {PDMS}. Also, {PA} was shown to be more efficient than {PDMS} for hydrophobic aromatic compounds.},
	pages = {1394--1400},
	number = {4},
	journaltitle = {Analytical Chemistry},
	shortjournal = {Anal. Chem.},
	author = {Endo, Satoshi and Droge, Steven T. J. and Goss, Kai-Uwe},
	urldate = {2017-04-11},
	date = {2011-02-15},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\G6C7G4JQ\\ac102868e.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\D7S94W2C\\Endo et al. - 2011 - Polyparameter Linear Free Energy Models for Polyac.pdf:application/pdf}
}

@article{zhang_compilation_2012-1,
	title = {Compilation of 222 drugs’ plasma protein binding data and guidance for study designs},
	volume = {17},
	issn = {1359-6446},
	url = {http://www.sciencedirect.com/science/article/pii/S1359644611004545},
	doi = {10.1016/j.drudis.2011.12.018},
	abstract = {The binding of a drug to plasma protein reduces free drug in the blood circulation that would otherwise be available for penetration into tissues to reach the therapeutic target or the kidney for elimination. Therefore, the binding event affects drug elimination from the body, efficacy, duration of action and toxicity. Co-administration of other drugs, food and pathological conditions of patients can significantly change percentage binding of the drug and result in serious consequences. Here, we present the largest and newest information on plasma protein binding for 222 drugs, of which 50\% show 90–100\% binding, a range that could be considered as a favorable element for future lead selection. We also provide critical and comprehensive evaluations on the methods and techniques established to determine plasma protein binding, pinpoint advantages and pitfalls of individual approaches, and offer detailed guidance for experimental designs, including ultrafiltration, equilibrium dialysis, ultracentrifugation, charcoal adsorption, high-performance affinity chromatography, high-performance frontal analysis, solid-phase microextraction and in vivo microdialysis.},
	pages = {475--485},
	number = {9},
	journaltitle = {Drug Discovery Today},
	shortjournal = {Drug Discovery Today},
	author = {Zhang, Fengling and Xue, Jinpin and Shao, Jingwei and Jia, Li},
	urldate = {2017-04-11},
	date = {2012-05},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\SFEP32D7\\S1359644611004545.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\9KUWNZMF\\Zhang et al. - 2012 - Compilation of 222 drugs’ plasma protein binding d.pdf:application/pdf}
}

@article{aggarwal_nanoparticle_2009,
	title = {Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy},
	volume = {61},
	issn = {0169-409X},
	url = {http://www.sciencedirect.com/science/article/pii/S0169409X0900101X},
	doi = {10.1016/j.addr.2009.03.009},
	series = {Identifying and Assessing Biomaterial Nanotoxicity in Translational Research for Preclinical Drug Development},
	abstract = {Proteins bind the surfaces of nanoparticles, and biological materials in general, immediately upon introduction of the materials into a physiological environment. The further biological response of the body is influenced by the nanoparticle–protein complex. The nanoparticle's composition and surface chemistry dictate the extent and specificity of protein binding. Protein binding is one of the key elements that affects biodistribution of the nanoparticles throughout the body. Here we review recent research on nanoparticle physicochemical properties important for protein binding, techniques for isolation and identification of nanoparticle-bound proteins, and how these proteins can influence particle biodistribution and biocompatibility. Understanding the nanoparticle–protein complex is necessary for control and manipulation of protein binding, and allows for improved engineering of nanoparticles with favorable bioavailability and biodistribution.},
	pages = {428--437},
	number = {6},
	journaltitle = {Advanced Drug Delivery Reviews},
	shortjournal = {Advanced Drug Delivery Reviews},
	author = {Aggarwal, Parag and Hall, Jennifer B. and {McLeland}, Christopher B. and Dobrovolskaia, Marina A. and {McNeil}, Scott E.},
	urldate = {2017-04-11},
	date = {2009-06-21},
	keywords = {Nanoparticles, Biocompatibility, Biodistribution, Immunology, Protein binding},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\FEXHDHN9\\S0169409X0900101X.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\ZHGTB7IQ\\Aggarwal et al. - 2009 - Nanoparticle interaction with plasma proteins as i.pdf:application/pdf}
}

@article{reyes-garces_high_2014-2,
	title = {High throughput quantification of prohibited substances in plasma using thin film solid phase microextraction},
	volume = {1374},
	issn = {00219673},
	url = {http://linkinghub.elsevier.com/retrieve/pii/S0021967314018056},
	doi = {10.1016/j.chroma.2014.11.047},
	pages = {40--49},
	journaltitle = {Journal of Chromatography A},
	author = {Reyes-Garcés, Nathaly and Bojko, Barbara and Pawliszyn, Janusz},
	urldate = {2017-04-11},
	date = {2014-12},
	langid = {english},
	file = {1-s2.0-S0021967314018056-main.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\W42QTU9I\\1-s2.0-S0021967314018056-main.pdf:application/pdf}
}

@article{mirabelli_direct_2016,
	title = {Direct Coupling of Solid-Phase Microextraction with Mass Spectrometry: Sub-pg/g Sensitivity Achieved Using a Dielectric Barrier Discharge Ionization Source},
	volume = {88},
	issn = {0003-2700, 1520-6882},
	url = {http://pubs.acs.org/doi/abs/10.1021/acs.analchem.6b01507},
	doi = {10.1021/acs.analchem.6b01507},
	shorttitle = {Direct Coupling of Solid-Phase Microextraction with Mass Spectrometry},
	pages = {7252--7258},
	number = {14},
	journaltitle = {Analytical Chemistry},
	author = {Mirabelli, Mario F. and Wolf, Jan-Christoph and Zenobi, Renato},
	urldate = {2017-04-07},
	date = {2016-07-19},
	langid = {english},
	file = {acs%2Eanalchem%2E6b01507.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\E3856CF7\\acs%2Eanalchem%2E6b01507.pdf:application/pdf}
}

@article{lynn_biosensing_2016,
	title = {(Bio)Sensing Using Nanoparticle Arrays: On the Effect of Analyte Transport on Sensitivity},
	volume = {88},
	issn = {0003-2700, 1520-6882},
	url = {http://pubs.acs.org/doi/abs/10.1021/acs.analchem.6b03002},
	doi = {10.1021/acs.analchem.6b03002},
	shorttitle = {(Bio)Sensing Using Nanoparticle Arrays},
	pages = {12145--12151},
	number = {24},
	journaltitle = {Analytical Chemistry},
	author = {Lynn, N. Scott and Homola, Jiří},
	urldate = {2017-04-07},
	date = {2016-12-20},
	langid = {english},
	file = {acs%2Eanalchem%2E6b03002.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\5VUS3T8B\\acs%2Eanalchem%2E6b03002.pdf:application/pdf}
}

@article{yalcin_optical_2006,
	title = {Optical sensing of biomolecules using microring resonators},
	volume = {12},
	url = {http://ieeexplore.ieee.org/abstract/document/1588894/},
	pages = {148--155},
	number = {1},
	journaltitle = {{IEEE} Journal of Selected Topics in Quantum Electronics},
	author = {Yalcin, Ayca and Popat, Ketul C. and Aldridge, John C. and Desai, Tejal A. and Hryniewicz, John and Chbouki, Nabil and Little, Brent E. and King, Oliver and Van, Vien and Chu, Sai and {others}},
	urldate = {2017-04-07},
	date = {2006},
	file = {boe-1-3-983.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\CRPTM9ZQ\\boe-1-3-983.pdf:application/pdf}
}

@article{gomez-rios_solid_2014,
	title = {Solid phase microextraction ({SPME})-transmission mode ({TM}) pushes down detection limits in direct analysis in real time ({DART})},
	volume = {50},
	issn = {1359-7345, 1364-548X},
	url = {http://xlink.rsc.org/?DOI=C4CC05301J},
	doi = {10.1039/C4CC05301J},
	pages = {12937--12940},
	number = {85},
	journaltitle = {Chem. Commun.},
	author = {Gómez-Ríos, Germán Augusto and Pawliszyn, Janusz},
	urldate = {2017-04-07},
	date = {2014-08-26},
	langid = {english},
	file = {C4CC05301J.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\QPBF68GF\\C4CC05301J.pdf:application/pdf}
}

@article{chen_magnetic_2015,
	title = {Magnetic solid phase extraction coupled with desorption corona beam ionization-mass spectrometry for rapid analysis of antidepressants in human body fluids},
	volume = {140},
	issn = {0003-2654, 1364-5528},
	url = {http://xlink.rsc.org/?DOI=C5AN00992H},
	doi = {10.1039/C5AN00992H},
	pages = {5662--5670},
	number = {16},
	journaltitle = {The Analyst},
	author = {Chen, Di and Zheng, Hao-Bo and Huang, Yun-Qing and Hu, Yu-Ning and Yu, Qiong-Wei and Yuan, Bi-Feng and Feng, Yu-Qi},
	urldate = {2017-04-07},
	date = {2015},
	langid = {english},
	file = {C5AN00992H.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\MPG4VP6M\\C5AN00992H.pdf:application/pdf}
}

@article{li_monolith_2016,
	title = {Monolith dip-it: a bifunctional device for improving the sensitivity of direct analysis in real time mass spectrometry},
	volume = {141},
	issn = {0003-2654, 1364-5528},
	url = {http://xlink.rsc.org/?DOI=C6AN00839A},
	doi = {10.1039/C6AN00839A},
	shorttitle = {Monolith dip-it},
	pages = {4947--4952},
	number = {16},
	journaltitle = {The Analyst},
	author = {Li, Xianjiang and Li, Ze and Wang, Xin and Nie, Honggang and Zhang, Yiding and Bai, Yu and Liu, Huwei},
	urldate = {2017-04-07},
	date = {2016},
	langid = {english},
	file = {C6AN00839A.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\6RAVZ7AR\\C6AN00839A.pdf:application/pdf}
}

@article{zhang_mass_1996-1,
	title = {Mass transfer at a microelectrode in channel flow},
	volume = {100},
	url = {http://jfi.uchicago.edu/~wzhang/sherwood.pdf},
	pages = {9462--9464},
	journaltitle = {Journal of Physical Chemistry},
	author = {Zhang, Wendy and Stone, H. A. and Sherwood, J. D. and {others}},
	urldate = {2017-04-07},
	date = {1996},
	file = {jp960027y.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\34WZKQ6V\\jp960027y.pdf:application/pdf}
}

@article{kusnezow_kinetics_2006-1,
	title = {Kinetics of antigen binding to antibody microspots: Strong limitation by mass transport to the surface},
	volume = {6},
	issn = {1615-9853, 1615-9861},
	url = {http://doi.wiley.com/10.1002/pmic.200500149},
	doi = {10.1002/pmic.200500149},
	shorttitle = {Kinetics of antigen binding to antibody microspots},
	pages = {794--803},
	number = {3},
	journaltitle = {{PROTEOMICS}},
	author = {Kusnezow, Wlad and Syagailo, Yana V. and Rüffer, Sven and Klenin, Konstantin and Sebald, Walter and Hoheisel, Jörg D. and Gauer, Christoph and Goychuk, Igor},
	urldate = {2017-04-07},
	date = {2006-02},
	langid = {english},
	file = {Kusnezow_et_al-2006-PROTEOMICS.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\SS8JZ5DF\\Kusnezow_et_al-2006-PROTEOMICS.pdf:application/pdf}
}

@article{kusnezow_optimal_2006,
	title = {Optimal design of microarray immunoassays to compensate for kinetic limitations theory and experiment},
	volume = {5},
	url = {http://www.mcponline.org/content/5/9/1681.short},
	pages = {1681--1696},
	number = {9},
	journaltitle = {Molecular \& Cellular Proteomics},
	author = {Kusnezow, Wlad and Syagailo, Yana V. and Rüffer, Sven and Baudenstiel, Nina and Gauer, Christoph and Hoheisel, Jörg D. and Wild, David and Goychuk, Igor},
	urldate = {2017-04-07},
	date = {2006},
	file = {Mol Cell Proteomics-2006-Kusnezow-1681-96.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\GG7C4FWK\\Mol Cell Proteomics-2006-Kusnezow-1681-96.pdf:application/pdf}
}

@article{melli_fast_2011,
	title = {Fast Detection of Biomolecules in Diffusion-Limited Regime Using Micromechanical Pillars},
	volume = {5},
	issn = {1936-0851, 1936-086X},
	url = {http://pubs.acs.org/doi/abs/10.1021/nn202224g},
	doi = {10.1021/nn202224g},
	pages = {7928--7935},
	number = {10},
	journaltitle = {{ACS} Nano},
	author = {Melli, Mauro and Scoles, Giacinto and Lazzarino, Marco},
	urldate = {2017-04-07},
	date = {2011-10-25},
	langid = {english},
	file = {nn202224g.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\6ITQHWD6\\nn202224g.pdf:application/pdf}
}

@article{de_angelis_breaking_2011,
	title = {Breaking the diffusion limit with super-hydrophobic delivery of molecules to plasmonic nanofocusing {SERS} structures},
	volume = {5},
	issn = {1749-4885, 1749-4893},
	url = {http://www.nature.com/doifinder/10.1038/nphoton.2011.222},
	doi = {10.1038/nphoton.2011.222},
	pages = {682--687},
	number = {11},
	journaltitle = {Nature Photonics},
	author = {De Angelis, F. and Gentile, F. and Mecarini, F. and Das, G. and Moretti, M. and Candeloro, P. and Coluccio, M. L. and Cojoc, G. and Accardo, A. and Liberale, C. and Zaccaria, R. P. and Perozziello, G. and Tirinato, L. and Toma, A. and Cuda, G. and Cingolani, R. and Di Fabrizio, E.},
	urldate = {2017-04-07},
	date = {2011-09-18},
	file = {nphoton.2011.222.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\ZUDEPN57\\nphoton.2011.222.pdf:application/pdf}
}

@collection{wild_immunoassay_2013,
	location = {Oxford ; Waltham, {MA}},
	edition = {4th ed},
	title = {The immunoassay handbook: theory and applications of ligand binding, {ELISA}, and related techniques},
	isbn = {978-0-08-097037-0},
	shorttitle = {The immunoassay handbook},
	pagetotal = {1013},
	publisher = {Elsevier},
	editor = {Wild, David},
	date = {2013},
	note = {{OCLC}: ocn813855389},
	keywords = {Immunoassay, methods, standards},
	file = {The-Immunoassay-Handbook-.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\4VTDDMVJ\\The-Immunoassay-Handbook-.pdf:application/pdf}
}

@article{ekins_development_1989,
	title = {Development of microspot multi-analyte ratiometric immunoassay using dual fluorescent-labelled antibodies},
	volume = {227},
	url = {http://www.sciencedirect.com/science/article/pii/S0003267000826471},
	pages = {73--96},
	journaltitle = {Analytica Chimica Acta},
	author = {Ekins, Roger and Chu, Frederick and Biggart, Elizabeth},
	urldate = {2017-04-07},
	date = {1989},
	file = {1-s2.0-S0003267000826471-main.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\Q9I25DQK\\1-s2.0-S0003267000826471-main.pdf:application/pdf}
}

@article{vasconcelos_magnetic_2017-1,
	title = {Magnetic solid phase extraction for determination of drugs in biological matrices},
	volume = {89},
	issn = {01659936},
	url = {http://linkinghub.elsevier.com/retrieve/pii/S0165993616302795},
	doi = {10.1016/j.trac.2016.11.011},
	pages = {41--52},
	journaltitle = {{TrAC} Trends in Analytical Chemistry},
	author = {Vasconcelos, Ingrid and Fernandes, Christian},
	urldate = {2017-04-07},
	date = {2017-04},
	langid = {english},
	file = {1-s2.0-S0165993616302795-main.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\7FTTMBRG\\1-s2.0-S0165993616302795-main.pdf:application/pdf}
}

@article{tascon_ultra-fast_2017,
	title = {Ultra-fast quantitation of voriconazole in human plasma by coated blade spray mass spectrometry},
	issn = {07317085},
	url = {http://linkinghub.elsevier.com/retrieve/pii/S0731708517305873},
	doi = {10.1016/j.jpba.2017.03.009},
	journaltitle = {Journal of Pharmaceutical and Biomedical Analysis},
	author = {Tascon, Marcos and Gómez-Ríos, Germán Augusto and Reyes-Garcés, Nathaly and Poole, Justen and Boyacı, Ezel and Pawliszyn, Janusz},
	urldate = {2017-04-07},
	date = {2017-03},
	langid = {english},
	file = {1-s2.0-S0731708517305873-main.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\Z3W2ATFX\\1-s2.0-S0731708517305873-main.pdf:application/pdf}
}

@article{wang_nanoscale_2017,
	title = {Nanoscale sensors for assuring the safety of food products},
	volume = {44},
	issn = {09581669},
	url = {http://linkinghub.elsevier.com/retrieve/pii/S0958166916302324},
	doi = {10.1016/j.copbio.2016.10.005},
	pages = {74--86},
	journaltitle = {Current Opinion in Biotechnology},
	author = {Wang, Yun and Duncan, Timothy V},
	urldate = {2017-04-07},
	date = {2017-04},
	langid = {english},
	file = {1-s2.0-S0958166916302324-main.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\C8W3IIM9\\1-s2.0-S0958166916302324-main.pdf:application/pdf}
}

@article{sheehan_detection_2005,
	title = {Detection Limits for Nanoscale Biosensors},
	volume = {5},
	issn = {1530-6984, 1530-6992},
	url = {http://pubs.acs.org/doi/abs/10.1021/nl050298x},
	doi = {10.1021/nl050298x},
	pages = {803--807},
	number = {4},
	journaltitle = {Nano Letters},
	author = {Sheehan, Paul E. and Whitman, Lloyd J.},
	urldate = {2017-04-07},
	date = {2005-04},
	langid = {english},
	file = {10.1.1.1025.6415.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\4J2WTFZE\\10.1.1.1025.6415.pdf:application/pdf}
}

@article{leary_mass_2015-1,
	title = {Mass transfer in the biomolecular binding of a target against probe molecules on the surface of microbeads sequestered in wells in a microfluidic cell},
	volume = {15},
	issn = {1473-0197, 1473-0189},
	url = {http://xlink.rsc.org/?DOI=C4LC01185F},
	doi = {10.1039/C4LC01185F},
	pages = {459--477},
	number = {2},
	journaltitle = {Lab Chip},
	author = {Leary, Thomas F. and Manafirasi, Setareh and Maldarelli, Charles},
	urldate = {2017-04-07},
	date = {2015},
	langid = {english},
	file = {2014_-_Thomas_F_Leary_-_Masstransferinthebiomolecularbindingofatargetagain[retrieved_2016-02-04].pdf:C\:\\Users\\nazmula\\Zotero\\storage\\SSF2P23D\\2014_-_Thomas_F_Leary_-_Masstransferinthebiomolecularbindingofatargetagain[retrieved_2016-02-04].pdf:application/pdf}
}

@article{tigli_biosensors_2013,
	title = {Biosensors in the small scale: methods and technology trends},
	volume = {7},
	issn = {1751-8741, 1751-875X},
	url = {http://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2012.0005},
	doi = {10.1049/iet-nbt.2012.0005},
	shorttitle = {Biosensors in the small scale},
	pages = {7--21},
	number = {1},
	journaltitle = {{IET} Nanobiotechnology},
	author = {Tigli, Onur and Senveli, Sukru U.},
	urldate = {2017-04-07},
	date = {2013-03-01},
	langid = {english},
	file = {06488933.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\SEPVBCNT\\06488933.pdf:application/pdf}
}

@article{sun_kinetic_2015-1,
	title = {Kinetic Analysis of Biomolecular Interactions Using Label-Free Biosensors},
	volume = {43},
	issn = {1073-9149, 1525-6030},
	url = {http://www.tandfonline.com/doi/abs/10.1080/10739149.2014.976830},
	doi = {10.1080/10739149.2014.976830},
	pages = {255--267},
	number = {2},
	journaltitle = {Instrumentation Science \& Technology},
	author = {Sun, Yung-Shin and Zhu, X. D.},
	urldate = {2017-04-07},
	date = {2015-03-04},
	langid = {english},
	file = {10739149%2E2014%2E976830.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\VNNMFJTJ\\10739149%2E2014%2E976830.pdf:application/pdf}
}

@article{fu_modeling_2009,
	title = {Modeling of a Competitive Microfluidic Heterogeneous Immunoassay: Sensitivity of the Assay Response to Varying System Parameters},
	volume = {81},
	issn = {0003-2700, 1520-6882},
	url = {http://pubs.acs.org/doi/abs/10.1021/ac802672v},
	doi = {10.1021/ac802672v},
	shorttitle = {Modeling of a Competitive Microfluidic Heterogeneous Immunoassay},
	pages = {3407--3413},
	number = {9},
	journaltitle = {Analytical Chemistry},
	author = {Fu, Elain and Nelson, Kjell E. and Ramsey, Stephen A. and Foley, Jennifer O. and Helton, Kristen and Yager, Paul},
	urldate = {2017-04-07},
	date = {2009-05},
	langid = {english},
	file = {ac802672v.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\9TDFEKNC\\ac802672v.pdf:application/pdf}
}

@article{noauthor_surface_nodate,
	title = {Surface Plasmon Resonance Method and Protocol},
	file = {bok%3A978-1-60761-670-2:C\:\\Users\\nazmula\\Zotero\\storage\\T7JB5NTM\\bok%3A978-1-60761-670-2.pdf:application/pdf}
}

@article{noauthor_microfluidics:_nodate,
	title = {Microfluidics: Fluid physics at the nanoliter scale},
	file = {Nucl. Acids Res.-2001-Peterson-5163-8:C\:\\Users\\nazmula\\Zotero\\storage\\DMM8VSI7\\Nucl. Acids Res.-2001-Peterson-5163-8.pdf:application/pdf}
}

@article{noauthor_microfluidics:_2005,
	title = {Microfluidics: Fluid physics at the nanoliter scale},
	date = {2005},
	file = {RevModPhys.77.977:C\:\\Users\\nazmula\\Zotero\\storage\\HRQPXMIW\\RevModPhys.77.977.pdf:application/pdf}
}

@article{zilliges_cyanobacterial_2011,
	title = {The Cyanobacterial Hepatotoxin Microcystin Binds to Proteins and Increases the Fitness of Microcystis under Oxidative Stress Conditions},
	volume = {6},
	issn = {1932-6203},
	url = {http://dx.plos.org/10.1371/journal.pone.0017615},
	doi = {10.1371/journal.pone.0017615},
	abstract = {Microcystins are cyanobacterial toxins that represent a serious threat to drinking water and recreational lakes worldwide. Here, we show that microcystin fulfils an important function within cells of its natural producer Microcystis. The microcystin deficient mutant {DmcyB} showed significant changes in the accumulation of proteins, including several enzymes of the Calvin cycle, phycobiliproteins and two {NADPH}-dependent reductases. We have discovered that microcystin binds to a number of these proteins in vivo and that the binding is strongly enhanced under high light and oxidative stress conditions. The nature of this binding was studied using extracts of a microcystin-deficient mutant in vitro. The data obtained provided clear evidence for a covalent interaction of the toxin with cysteine residues of proteins. A detailed investigation of one of the binding partners, the large subunit of {RubisCO} showed a lower susceptibility to proteases in the presence of microcystin in the wild type. Finally, the mutant defective in microcystin production exhibited a clearly increased sensitivity under high light conditions and after hydrogen peroxide treatment. Taken together, our data suggest a protein-modulating role for microcystin within the producing cell, which represents a new addition to the catalogue of functions that have been discussed for microbial secondary metabolites.},
	pages = {e17615},
	number = {3},
	journaltitle = {{PLoS} {ONE}},
	author = {Zilliges, Yvonne and Kehr, Jan-Christoph and Meissner, Sven and Ishida, Keishi and Mikkat, Stefan and Hagemann, Martin and Kaplan, Aaron and Börner, Thomas and Dittmann, Elke},
	editor = {Otto, Michael},
	urldate = {2018-05-30},
	date = {2011-03-18},
	langid = {english},
	file = {Zilliges et al. - 2011 - The Cyanobacterial Hepatotoxin Microcystin Binds t.PDF:C\:\\Users\\nazmula\\Zotero\\storage\\ZJWHAN6L\\Zilliges et al. - 2011 - The Cyanobacterial Hepatotoxin Microcystin Binds t.PDF:application/pdf}
}

@article{zong_molecular_2017,
	title = {Molecular Mechanism for the Regulation of Microcystin Toxicity to Protein Phosphatase 1 by Glutathione Conjugation Pathway},
	volume = {2017},
	issn = {2314-6133, 2314-6141},
	url = {https://www.hindawi.com/journals/bmri/2017/9676504/},
	doi = {10.1155/2017/9676504},
	pages = {1--10},
	journaltitle = {{BioMed} Research International},
	author = {Zong, Wansong and Wang, Xiaoning and Du, Yonggang and Zhang, Shuhan and Zhang, Ying and Teng, Yue},
	urldate = {2018-05-30},
	date = {2017},
	langid = {english},
	file = {Zong et al. - 2017 - Molecular Mechanism for the Regulation of Microcys.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\C4TWP6VL\\Zong et al. - 2017 - Molecular Mechanism for the Regulation of Microcys.pdf:application/pdf}
}

@article{wei_microcystin-bound_2016,
	title = {Microcystin-Bound Protein Patterns in Different Cultures of Microcystis aeruginosa and Field Samples},
	volume = {8},
	issn = {2072-6651},
	url = {http://www.mdpi.com/2072-6651/8/10/293},
	doi = {10.3390/toxins8100293},
	abstract = {Micocystin ({MC}) exists in Microcystis cells in two different forms, free and protein-bound. We examined the dynamic change in extracellular free {MCs}, intracellular free {MCs} and protein-bound {MCs} in both batch cultures and semi-continuous cultures, using high performance liquid chromatography and Western blot. The results showed that the free {MC} per cell remained constant, while the quantity of protein-bound {MCs} increased with the growth of Microcystis cells in both kinds of culture. Signiﬁcant changes in the dominant {MC}-bound proteins occurred in the late exponential growth phase of batch cultures, while the dominant {MC}-bound proteins in semi-continuous cultures remained the same. In ﬁeld samples collected at different months in Lake Taihu, the dominant {MC}-bound proteins were shown to be similar, but the amount of protein-bound {MC} varied and correlated with the intracellular {MC} content. We identiﬁed {MC}-bound proteins by two-dimensional electrophoresis immunoblots and mass spectrometry. The 60 {kDa} chaperonin {GroEL} was a prominent {MC}-bound protein. Three essential glycolytic enzymes and {ATP} synthase alpha subunit were also major targets of {MC}-binding, which might contribute to sustained growth in semi-continuous culture. Our results indicate that protein-bound {MC} may be important for sustaining growth and adaptation of Microcystis sp.},
	pages = {293},
	number = {10},
	journaltitle = {Toxins},
	author = {Wei, Nian and Hu, Lili and Song, Lirong and Gan, Nanqin},
	urldate = {2018-05-30},
	date = {2016-10-12},
	langid = {english},
	file = {Wei et al. - 2016 - Microcystin-Bound Protein Patterns in Different Cu.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\KWN23JZX\\Wei et al. - 2016 - Microcystin-Bound Protein Patterns in Different Cu.pdf:application/pdf}
}

@article{wituszynski_microcystin_2017,
	title = {Microcystin in Lake Erie fish: Risk to human health and relationship to cyanobacterial blooms},
	volume = {43},
	issn = {03801330},
	url = {http://linkinghub.elsevier.com/retrieve/pii/S0380133017301260},
	doi = {10.1016/j.jglr.2017.08.006},
	shorttitle = {Microcystin in Lake Erie fish},
	abstract = {Microcystin ({MC}) is a cyanobacteria-produced liver toxin that has been found in ﬁsh from Lake Erie, sometimes in excess of World Health Organization ({WHO}) guidelines for safe consumption. Even so, few studies have quantiﬁed {MCs} in Lake Erie ﬁshes, and these studies have drawn different conclusions concerning the risk that ﬁsh consumption poses to public health. To address this gap in knowledge, we used Enzyme-Linked Immunosorbant Assay ({ELISA}) to evaluate the {MC} concentration in muscle tissue from three commonly harvested ﬁsh in Lake Erie: walleye (Sander vitreus, n = 29); yellow perch (Perca ﬂavescens, n = 52); and white perch (Morone americana, n = 55), collected during summer 2013. Satellite remote sensing was used to compare {MC} concentrations in ﬁsh tissue to bloom conditions in Lake Erie at the time of harvest. We found a signiﬁcant difference among mean {MC} concentrations in walleye (71 ng {MC}/g wet weight), white perch (37 ng {MC}/g), and yellow perch (8.1 ng {MC}/g). In addition, {MC} levels in white perch appeared to depend on local bloom conditions. While few of the ﬁsh collected contained {MC} in excess of {WHO} guidelines, our results indicate that more toxic blooms could increase {MC} in ﬁsh to levels that pose a greater risk to public health.},
	pages = {1084--1090},
	number = {6},
	journaltitle = {Journal of Great Lakes Research},
	author = {Wituszynski, David M. and Hu, Chenlin and Zhang, Feng and Chaffin, Justin D. and Lee, Jiyoung and Ludsin, Stuart A. and Martin, Jay F.},
	urldate = {2018-05-30},
	date = {2017-12},
	langid = {english},
	file = {Wituszynski et al. - 2017 - Microcystin in Lake Erie fish Risk to human healt.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\63NLEUFN\\Wituszynski et al. - 2017 - Microcystin in Lake Erie fish Risk to human healt.pdf:application/pdf}
}

@article{wood_changes_2006,
	title = {Changes in concentrations of microcystins in rainbow trout, freshwater mussels, and cyanobacteria in Lakes Rotoiti and Rotoehu},
	volume = {21},
	issn = {1520-4081, 1522-7278},
	url = {http://doi.wiley.com/10.1002/tox.20174},
	doi = {10.1002/tox.20174},
	abstract = {Microcystin concentrations in cyanobacteria and their accumulation in rainbow trout (Oncorhynchus mykiss) and freshwater mussels (Hyridella menziesi) in Lakes Rotoiti and Rotoehu (New Zealand) were investigated. Hatchery rainbow trout were added to an enclosure in Lake Rotoiti where concentrations of microcystins in the phytoplankton and cyanobacterial cell concentrations could be closely monitored. Rainbow trout that were free to roam in the entire area of each lake were also included in the study. Freshwater mussels were suspended subsurface in cages in the enclosure. Phytoplankton samples, rainbow trout liver and muscle tissue, and the tissues of mussels were analyzed for microcystins using the {ADDA}-{ELISA} method, and selected samples were analyzed using {LC}-{MS}. A maximum concentration of microcystins in the phytoplankton samples of 760  g {LÀ}1 was recorded in Te Weta Bay, Lake Rotoiti, in March 2004. {ELISA} results conﬁrmed microcystin immunoreactivity in rainbow trout liver and muscle tissues and in freshwater mussels. The microcystin congeners {LR}, {YR}, {RR}, {AR}, {FR}, {LA}, and {WR} were detected by {LC}-{MS} in caged freshwater mussels in Lake Rotoiti but were not detected in either muscle or liver tissue of rainbow trout. The daily tolerable intake limit of microcystins for human consumption recommended by the World Health Organisation is 0.04  g {kgÀ}1 {dayÀ}1. Modeling was carried out for the human intake of microcystin compounds from rainbow trout muscle tissue, and the potential health risks were estimated, assuming the {ADDA}-{ELISA} was determining compounds of toxicity equivalent to {microcystinLR}. \# 2006 Wiley Periodicals, Inc. Environ Toxicol 21: 205–222, 2006.},
	pages = {205--222},
	number = {3},
	journaltitle = {Environmental Toxicology},
	author = {Wood, S. A. and Briggs, L. R. and Sprosen, J. and Ruck, J. G. and Wear, R. G. and Holland, P. T. and Bloxham, M.},
	urldate = {2018-05-30},
	date = {2006-06},
	langid = {english},
	file = {Wood et al. - 2006 - Changes in concentrations of microcystins in rainb.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\5GU35DWH\\Wood et al. - 2006 - Changes in concentrations of microcystins in rainb.pdf:application/pdf}
}

@article{xie_organ_2005,
	title = {Organ distribution and bioaccumulation of microcystins in freshwater fish at different trophic levels from the eutrophic Lake Chaohu, China},
	volume = {20},
	issn = {1520-4081, 1522-7278},
	url = {http://doi.wiley.com/10.1002/tox.20120},
	doi = {10.1002/tox.20120},
	abstract = {This article reports the organ distribution and bioaccumulation of hepatotoxic microcystins ({MCs}) in freshwater ﬁshes at different trophic levels from the large, shallow, eutrophic Lake Chaohu in September 2003, when there were heavy surface blooms of toxic cyanobacteria. Among all ﬁsh, intestines and blood had the highest average content of {MC}-{RR} þ {MC}-{LR} (22.0 and 14.5  g {gÀ}1 {DW}, respectively), followed by liver, bile, and kidney (7.77, 6.32, and 5.81  g {gÀ}1 {DW}, respectively), whereas muscle had the least (1.81  g {gÀ}1 {DW}). {MC} content in muscle was highest in carnivorous ﬁsh (Culter ilishaeformis, 2.22  g {gÀ}1 {DW}) and omnivorous ﬁsh (Carassius auratus, 1.96  g {gÀ}1 {DW}) and was lowest in phytoplanktivorous ﬁsh (Hypophthalmichthys molitrix, 1.65  g {gÀ}1 {DW}) and herbivorous ﬁsh (Parabramis pekinensis 0.660  g {gÀ}1 {DW}). However, the amount of {MC} in the gut of H. molitrix (137  g {gÀ}1 {DW}) was more than 20 times that in the other ﬁsh ({\textless}6.50  g {gÀ}1 {DW}). The {MCs} showed a tendency to accumulate up the food chain, and piscivorous ﬁsh at the top of the food chain were at high risk of exposure to {MCs} in Lake Chaohu. Our study is the ﬁrst to report {MC} concentrations in the bile and blood of wild ﬁsh. One hundred grams of ﬁsh muscle would contain 2.64–49.7  g of {MC}-{LR} equivalent, or about 1.3–25 times the recommended tolerable daily intake of {MC}-{LR} by humans, indicating that ﬁsh are already severely contaminated by {MCs} and that the local authorities should warn the public of the risk of poisoning by eating the contaminated ﬁsh. ' 2005 Wiley Periodicals, Inc. Environ Toxicol 20: 293–300, 2005.},
	pages = {293--300},
	number = {3},
	journaltitle = {Environmental Toxicology},
	author = {Xie, Liqiang and Xie, Ping and Guo, Longgen and Li, Li and Miyabara, Yuichi and Park, Ho-Dong},
	urldate = {2018-05-30},
	date = {2005-06},
	langid = {english},
	file = {Xie et al. - 2005 - Organ distribution and bioaccumulation of microcys.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\KRYREIFY\\Xie et al. - 2005 - Organ distribution and bioaccumulation of microcys.pdf:application/pdf}
}

@article{xie_determination_2007,
	title = {Determination of microcystins in fish tissues using {HPLC} with a rapid and efficient solid phase extraction},
	volume = {271},
	issn = {00448486},
	url = {http://linkinghub.elsevier.com/retrieve/pii/S0044848607005583},
	doi = {10.1016/j.aquaculture.2007.07.004},
	abstract = {The presence of toxic cyanobacterial blooms have caused severe problems for aquatic animals, wildlife and humans. Monitoring of microcystins ({MCs}) in fish and other aquatic animals is important for evaluating the potential risk for human consumption. Existing methods for extracting and purifying microcystins in fish tissue are both time- and solvent-consuming. The present study used {HLB} (0.5 g) and silica gel (2 g)/plus silica gel (0.69 g) tandem cartridges to isolate microcystins from fish tissue samples for subsequent analysis by high-performance liquid chromatography with photodiode array detection ({HPLC}-{PDA}). The microcystins ({MC}-{RR}, {MC}-{LR}) were isolated from a Microcystis bloom in Chikato Pond, Japan, and the purity was confirmed by {HPLC}. This report has presented a simple and rapid solid phase extraction procedure for determining microcystins in fish tissue, since it yielded high recovery (N 85\%) and consistency ({SD} b 5\%) in isolating microcystins from fish tissue.},
	pages = {530--536},
	number = {1},
	journaltitle = {Aquaculture},
	author = {Xie, Liqiang and Park, Ho-Dong},
	urldate = {2018-05-30},
	date = {2007-10},
	langid = {english},
	file = {Xie and Park - 2007 - Determination of microcystins in fish tissues usin.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\QRRFF6IU\\Xie and Park - 2007 - Determination of microcystins in fish tissues usin.pdf:application/pdf}
}

@article{zhang_transformation_2016,
	title = {Transformation of microcystins to 2-methyl-3-methoxy-4-phenylbutyric acid by room temperature ozone oxidation for rapid quantification of total microcystins},
	volume = {18},
	issn = {2050-7887, 2050-7895},
	url = {http://xlink.rsc.org/?DOI=C5EM00588D},
	doi = {10.1039/C5EM00588D},
	pages = {493--499},
	number = {4},
	journaltitle = {Environmental Science: Processes \& Impacts},
	author = {Zhang, L. L. and Yu, R. P. and Wang, L. P. and Wu, S. F. and Song, Q. J.},
	urldate = {2018-05-30},
	date = {2016},
	langid = {english},
	file = {Zhang et al. - 2016 - Transformation of microcystins to 2-methyl-3-metho.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\3J7NS9HL\\Zhang et al. - 2016 - Transformation of microcystins to 2-methyl-3-metho.pdf:application/pdf}
}

@article{ser_extraction_2015,
	title = {Extraction parameters for metabolomics from cultured cells},
	volume = {475},
	issn = {00032697},
	url = {http://linkinghub.elsevier.com/retrieve/pii/S000326971500007X},
	doi = {10.1016/j.ab.2015.01.003},
	abstract = {The successful extraction of metabolites is a critical step in metabolite proﬁling. By optimizing metabolite extraction, the range and quantitative capacity of metabolomics studies can be improved. We considered eight separate extraction protocols for the preparation of a metabolite extract from cultured mammalian cells. Parameters considered included temperature, {pH}, and cell washing before extraction. The effects on metabolite recovery were studied using a liquid chromatography high-resolution mass spectrometry ({LC}–{HRMS}) platform that measures metabolites of diverse chemical classes, including amino acids, lipids, and sugar derivatives. The temperature considered during the extraction or the presence of formic acid, a commonly used additive, was shown to have minimal effects on the measured ion intensities of metabolites. However, washing of samples before metabolite extraction, whether with water or phosphate-buffered saline, exhibited dramatic effects on measured intensities of both intracellular and extracellular metabolites. Together, these ﬁndings present a systematic assessment of extraction conditions for metabolite proﬁling.},
	pages = {22--28},
	journaltitle = {Analytical Biochemistry},
	author = {Ser, Zheng and Liu, Xiaojing and Tang, Ngoc Nu and Locasale, Jason W.},
	urldate = {2018-05-30},
	date = {2015-04},
	langid = {english},
	file = {Ser et al. - 2015 - Extraction parameters for metabolomics from cultur.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\79NEM77R\\Ser et al. - 2015 - Extraction parameters for metabolomics from cultur.pdf:application/pdf}
}

@article{romisch-margl_procedure_2012,
	title = {Procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics},
	volume = {8},
	issn = {1573-3882, 1573-3890},
	url = {http://link.springer.com/10.1007/s11306-011-0293-4},
	doi = {10.1007/s11306-011-0293-4},
	pages = {133--142},
	number = {1},
	journaltitle = {Metabolomics},
	author = {Römisch-Margl, Werner and Prehn, Cornelia and Bogumil, Ralf and Röhring, Cornelia and Suhre, Karsten and Adamski, Jerzy},
	urldate = {2018-05-30},
	date = {2012-02},
	langid = {english},
	file = {Römisch-Margl et al. - 2012 - Procedure for tissue sample preparation and metabo.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\ZG59SNIN\\Römisch-Margl et al. - 2012 - Procedure for tissue sample preparation and metabo.pdf:application/pdf}
}

@article{zukunft_high-throughput_2018,
	title = {High-throughput extraction and quantification method for targeted metabolomics in murine tissues},
	volume = {14},
	issn = {1573-3882, 1573-3890},
	url = {http://link.springer.com/10.1007/s11306-017-1312-x},
	doi = {10.1007/s11306-017-1312-x},
	abstract = {Introduction  Global metabolomics analyses using body fluids provide valuable results for the understanding and prediction of diseases. However, the mechanism of a disease is often tissue-based and it is advantageous to analyze metabolomic changes directly in the tissue. Metabolomics from tissue samples faces many challenges like tissue collection, homogenization, and metabolite extraction.
Objectives  We aimed to establish a metabolite extraction protocol optimized for tissue metabolite quantification by the targeted metabolomics {AbsoluteIDQ}™ p180 Kit (Biocrates). The extraction method should be non-selective, applicable to different kinds and amounts of tissues, monophasic, reproducible, and amenable to high throughput.
Methods  We quantified metabolites in samples of eleven murine tissues after extraction with three solvents (methanol, phosphate buffer, ethanol/phosphate buffer mixture) in two tissue to solvent ratios and analyzed the extraction yield, ionization efficiency, and reproducibility.
Results  We found methanol and ethanol/phosphate buffer to be superior to phosphate buffer in regard to extraction yield, reproducibility, and ionization efficiency for all metabolites measured. Phosphate buffer, however, outperformed both organic solvents for amino acids and biogenic amines but yielded unsatisfactory results for lipids. The observed matrix effects of tissue extracts were smaller or in a similar range compared to those of human plasma.
Conclusion  We provide for each murine tissue type an optimized high-throughput metabolite extraction protocol, which yields the best results for extraction, reproducibility, and quantification of metabolites in the p180 kit. Although the performance of the extraction protocol was monitored by the p180 kit, the protocol can be applicable to other targeted metabolomics assays.},
	number = {1},
	journaltitle = {Metabolomics},
	author = {Zukunft, Sven and Prehn, Cornelia and Röhring, Cornelia and Möller, Gabriele and Hrabě de Angelis, Martin and Adamski, Jerzy and Tokarz, Janina},
	urldate = {2018-05-30},
	date = {2018-01},
	langid = {english},
	file = {Zukunft et al. - 2018 - High-throughput extraction and quantification meth.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\SRGENGRM\\Zukunft et al. - 2018 - High-throughput extraction and quantification meth.pdf:application/pdf}
}

@article{lu_metabolite_2017,
	title = {Metabolite Measurement: Pitfalls to Avoid and Practices to Follow},
	volume = {86},
	issn = {0066-4154, 1545-4509},
	url = {http://www.annualreviews.org/doi/10.1146/annurev-biochem-061516-044952},
	doi = {10.1146/annurev-biochem-061516-044952},
	shorttitle = {Metabolite Measurement},
	abstract = {Metabolites are the small biological molecules involved in energy conversion and biosynthesis. Studying metabolism is inherently challenging due to metabolites’ reactivity, structural diversity, and broad concentration range. Herein, we review the common pitfalls encountered in metabolomics and provide concrete guidelines for obtaining accurate metabolite measurements, focusing on water-soluble primary metabolites. We show how seemingly straightforward sample preparation methods can introduce systematic errors (e.g., owing to interconversion among metabolites) and how proper selection of quenching solvent (e.g., acidic acetonitrile:methanol:water) can mitigate such problems. We discuss the speciﬁc strengths, pitfalls, and best practices for each common analytical platform: liquid chromatography-mass spectrometry ({LC}-{MS}), gas chromatography-mass spectrometry ({GC}-{MS}), nuclear magnetic resonance ({NMR}), and enzyme assays. Together this information provides a pragmatic knowledge base for carrying out biologically informative metabolite measurements.},
	pages = {277--304},
	number = {1},
	journaltitle = {Annual Review of Biochemistry},
	author = {Lu, Wenyun and Su, Xiaoyang and Klein, Matthias S. and Lewis, Ian A. and Fiehn, Oliver and Rabinowitz, Joshua D.},
	urldate = {2018-05-30},
	date = {2017-06-20},
	langid = {english},
	file = {Lu et al. - 2017 - Metabolite Measurement Pitfalls to Avoid and Prac.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\U2X7APIH\\Lu et al. - 2017 - Metabolite Measurement Pitfalls to Avoid and Prac.pdf:application/pdf}
}

@article{abdel-latif_subchronic_2017,
	title = {Subchronic toxicity of Nile tilapia with different exposure routes to Microcystis aeruginosa: Histopathology, liver functions, and oxidative stress biomarkers},
	volume = {10},
	issn = {09728988, 22310916},
	url = {http://www.veterinaryworld.org/Vol.10/August-2017/21.html},
	doi = {10.14202/vetworld.2017.955-963},
	shorttitle = {Subchronic toxicity of Nile tilapia with different exposure routes to Microcystis aeruginosa},
	abstract = {Background: Toxic cyanobacterial blooms (Microcystis aeruginosa contains microcystins [{MCs}]) have been reported to induce clinicopathological alterations as well as different oxidative stress in aquatic biota. Aim: Three-week subchronic exposure experiment was carried out on Nile tilapia, to determine their effects on fish behavior, tissues, liver functions, antioxidant enzymes, and lipid peroxidation. Materials and Methods: Fish were exposed to four main treatments; orally fed diet plus toxic cells of M. aeruginosa (containing 3500 µg/g {MC}-{LR}), immersion in 500 µg {MC}-{LR}/L, intraperitoneal injection of M. aeruginosa {MC}-{LR} with a dose of 0.1 ml of extracted toxin at a dose of 200 μg/kg bwt, and the fourth one served as a control group, then the fish were sacrificed at the end of 3rd week of exposure.
Results: The results revealed no recorded mortality with obvious behavioral changes and an enlarged liver with the congested gall bladder. Histopathology demonstrated fragmentation, hyalinization, and necrosis of the subcutaneous musculature marked fatty degeneration, and vacuolation of hepatopancreatic cells with adhesion of the secondary gill lamellae associated with severe leukocytic infiltration. Furthermore, liver functions enzymes (aspartate aminotransferase and alanine aminotransferase, and the activities of glutathione peroxidase, glutathione reductase, lipid peroxidase, and catalase enzymes) were significantly increased in all treatments starting from the 2nd week as compared to the control levels.
Conclusion: In this context, the study addresses the possible toxicological impacts of toxic M. aeruginosa contain {MC}-{LR} to Nile tilapia, and the results investigated that {MC}-{LR} is toxic to Nile tilapia in different routes of exposure as well as different doses.},
	pages = {955--963},
	number = {8},
	journaltitle = {Veterinary World},
	author = {Abdel-Latif, H. M. R. and Khashaba, A. M. Abou},
	urldate = {2018-05-30},
	date = {2017-08},
	langid = {english},
	file = {Abdel-Latif and Khashaba - 2017 - Subchronic toxicity of Nile tilapia with different.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\KHHLF3U7\\Abdel-Latif and Khashaba - 2017 - Subchronic toxicity of Nile tilapia with different.pdf:application/pdf}
}

@article{baralla_microcystins_2017,
	title = {Microcystins Presence in Mussels \textit{(M. galloprovincialis)} and Water of Two Productive Mediterranean’s Lagoons (Sardinia, Italy)},
	volume = {2017},
	issn = {2314-6133, 2314-6141},
	url = {https://www.hindawi.com/journals/bmri/2017/3769245/},
	doi = {10.1155/2017/3769245},
	pages = {1--7},
	journaltitle = {{BioMed} Research International},
	author = {Baralla, Elena and Varoni, Maria Vittoria and Sedda, Tiziana and Pasciu, Valeria and Floris, Antonello and Demontis, Maria Piera},
	urldate = {2018-05-30},
	date = {2017},
	langid = {english},
	file = {Baralla et al. - 2017 - Microcystins Presence in Mussels i(M. galloprovi.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\Q46975X6\\Baralla et al. - 2017 - Microcystins Presence in Mussels i(M. galloprovi.pdf:application/pdf}
}

@article{cadel-six_detection_2014,
	title = {Detection of free and covalently bound microcystins in different tissues (liver, intestines, gills, and muscles) of rainbow trout (Oncorhynchus mykiss) by liquid chromatography–tandem mass spectrometry: Method characterization},
	volume = {185},
	issn = {02697491},
	url = {http://linkinghub.elsevier.com/retrieve/pii/S0269749113005447},
	doi = {10.1016/j.envpol.2013.10.016},
	shorttitle = {Detection of free and covalently bound microcystins in different tissues (liver, intestines, gills, and muscles) of rainbow trout (Oncorhynchus mykiss) by liquid chromatography–tandem mass spectrometry},
	abstract = {So far only a few publications have explored the development of extraction methods of cyanotoxin extracted from complex matrices. With regard to cyanobacterial microcystins ({MCs}), the data on the contamination of the ﬂesh of aquatic organisms is hard to compare and very limited due to the lack of validated methods. In recent years, evidence that both free and bound fractions of toxin are found in these tissues has highlighted the need to develop effective methods of quantiﬁcation. Several techniques do exist, but only the Lemieux oxidation has so far been used to investigate complex tissue matrices. In this study, protocols based on the Lemieux approach were adapted for the quantitative chemical analysis of free {MC}-{LR} and {MMPB} derived from bound toxin in the tissues of juvenile trout gavaged with {MC}-{LR}. Afterwards, the {NF} V03 110 guideline was used to characterize the protocols elaborated and evaluate their effectiveness.},
	pages = {333--339},
	journaltitle = {Environmental Pollution},
	author = {Cadel-Six, Sabrina and Moyenga, David and Magny, Stéphanie and Trotereau, Sophie and Edery, Marc and Krys, Sophie},
	urldate = {2018-05-30},
	date = {2014-02},
	langid = {english},
	file = {Cadel-Six et al. - 2014 - Detection of free and covalently bound microcystin.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\JDVYDHFW\\Cadel-Six et al. - 2014 - Detection of free and covalently bound microcystin.pdf:application/pdf}
}

@article{chen_microcystin_2007,
	title = {{MICROCYSTIN} {ACCUMULATION} {IN} {FRESHWATER} {BIVALVES} {FROM} {LAKE} {TAIHU}, {CHINA}, {AND} {THE} {POTENTIAL} {RISK} {TO} {HUMAN} {CONSUMPTION}},
	volume = {26},
	issn = {0730-7268, 1552-8618},
	url = {http://doi.wiley.com/10.1897/06-423R1.1},
	doi = {10.1897/06-423R1.1},
	abstract = {The potential risk through ingestion of microcystins ({MC}) in contaminated mollusks has not been well studied. The present paper studied seasonal changes of {MC} content (determined by liquid chromatography–mass spectrometry) in various organs of three species of bivalves (Cristaria plicata, Hyriopsis cumingii, and Lamprotula leai) in Lake Taihu, China, where toxic cyanobacterial blooms occurred. Coinciding with peaks of seston {MC} (maximum, 5.7 ␮g/L) and {MC} in cyanobacterial blooms (maximum, 0.534 mg/g), most organs showed sharp {MC} peaks during the summer, indicating both fast uptake and fast depuration by bivalves. Because hepatopancreas and intestine had considerably higher {MC} content than other organs, they are the most dangerous for human consumption. Both the present and previous studies show that the hepatopancreatic {MC} and total tissue {MC} often are correlated in various aquatic invertebrates. During the peak of the cyanobacterial blooms, C. plicata had higher hepatopancreatic {MC} content than the other bivalves, whereas H. cumingii had higher intestinal {MC} content than the other bivalves. Estimated daily intakes for humans from the consumption of whole tissues of the three bivalves were 0.48 to 0.94 ␮g {MC}-{LR} equivalent/kg body weight (12- to 23.5-fold the tolerable daily intake value proposed by the World Health Organization), which indicates a high risk for humans consuming these bivalves.},
	pages = {1066},
	number = {5},
	journaltitle = {Environmental Toxicology and Chemistry},
	author = {Chen, Jun and Xie, Ping},
	urldate = {2018-05-30},
	date = {2007},
	langid = {english},
	file = {Chen and Xie - 2007 - MICROCYSTIN ACCUMULATION IN FRESHWATER BIVALVES FR.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\9BS5EEHB\\Chen and Xie - 2007 - MICROCYSTIN ACCUMULATION IN FRESHWATER BIVALVES FR.pdf:application/pdf}
}

@article{deblois_microcystin_2008,
	title = {Microcystin accumulation in liver and muscle of tilapia in two large Brazilian hydroelectric reservoirs},
	volume = {51},
	issn = {00410101},
	url = {http://linkinghub.elsevier.com/retrieve/pii/S0041010107003923},
	doi = {10.1016/j.toxicon.2007.10.017},
	abstract = {The objective of this study was to measure levels of the toxin microcystin in different tissues of ﬁsh known to feed on cyanobacteria during toxic bloom events. Wild Nile and redbreast tilapia (Oreochromis niloticus and Tilapia rendalli) were sampled from the catch of artisanal ﬁshermen at eutrophic stations of Funil and Furnas reservoirs in southeastern Brazil. Phytoplankton communities in the two reservoirs were quite different taxonomically, but not dissimilar in microcystin content (200 mg g dry weight ({DW}) {sestonÀ}1 at Funil, 800 mg {gDW} {sestonÀ}1 at Furnas). All of the 27 ﬁsh sampled contained microcystin, ranging from 0.8 to 32.1 mg g {liverÀ}1 and from 0.9 to 12.0 ng g {muscleÀ}1. Most microcystin variants found in seston were also found in ﬁsh liver. T. rendalli had the lowest concentration in both tissues when compared to O. niloticus. In both reservoirs, one of every four ﬁsh sampled, always O. niloticus, had a level of microcystins beyond the World Health Organization tolerable daily intake (8 ng g {tissueÀ}1) and represented a risk for consumers. It is possible that closer study of inter-species variability in toxin burden in cyanobacteria-impacted water bodies will permit the development of guidelines for ﬁsh consumption that will better protect public health.},
	pages = {435--448},

repository: drnazmul/ayusuf

repo_name: drnazmul/ayusuf

extension: bib