text:
number = {2},
	journaltitle = {Analytical Biochemistry},
	shortjournal = {Analytical Biochemistry},
	author = {Christensen, Lars L. H.},
	urldate = {2017-02-02},
	date = {1997-07-01},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\EXH7W9NP\\S0003269797921825.html:text/html}
}

@collection{mol_surface_2010,
	location = {Totowa, {NJ}},
	title = {Surface Plasmon Resonance},
	volume = {627},
	isbn = {978-1-60761-669-6 978-1-60761-670-2},
	url = {http://link.springer.com/10.1007/978-1-60761-670-2},
	series = {Methods in Molecular Biology},
	publisher = {Humana Press},
	editor = {Mol, Nico J. and Fischer, Marcel J. E.},
	urldate = {2017-02-02},
	date = {2010},
	doi = {10.1007/978-1-60761-670-2},
	file = {bok%3A978-1-60761-670-2.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\AI96UII4\\bok%3A978-1-60761-670-2.pdf:application/pdf}
}

@inproceedings{izquierdo_computer_2015,
	title = {A computer model for the prediction of sensitivity in {SPR} sensing platforms},
	volume = {9340},
	url = {http://dx.doi.org/10.1117/12.2079684},
	doi = {10.1117/12.2079684},
	abstract = {Surface Plasmon Resonance ({SPR}) is a wave phenomenon occurring at a metal-dielectric interface. A {SPR}-based biosensor operates by monitoring changes in the refractive index close to the interface that are produced in response to the interaction between the analyte and the receptors immobilized on the metal’s surface. The performance of these sensors depends on many parameters, including channel geometry, material properties and parameters related to chemical interaction between the analyte and immobilized receptors. This paper presents an integrated model that predicts the sensitivity of an {SPR}-based sensing platform under the Kretschmann configuration. The model uses the analytical solution of the differential equations that describe the analyte-bioreceptor interaction to correlate changes in analyte concentration to changes in refractive index at the sensing surface. These results are then connected with {COMSOL} simulations that relate changes in refractive index to changes in the {SPR} reflectivity curves. The resultant relations are integrated and the model is evaluated under different scenarios. This model will aid in the optimization of assay parameters prior to experimentation for maximum sensitivity; saving both time and expensive chemical reagents during the experimental phase.},
	pages = {93400E--93400E--11},
	author = {Izquierdo, Kristel D. and Salazar, Arnoldo and Losoya-Leal, Adrian and Martinez-Chapa, Sergio O.},
	urldate = {2017-02-02},
	date = {2015},
	file = {Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\G5SVHHV2\\Izquierdo et al. - 2015 - A computer model for the prediction of sensitivity.pdf:application/pdf}
}

@article{jin_applicability_2013,
	title = {Applicability of Passive Sampling to Bioanalytical Screening of Bioaccumulative Chemicals in Marine Wildlife},
	volume = {47},
	issn = {0013-936X, 1520-5851},
	url = {http://pubs.acs.org/doi/abs/10.1021/es401014b},
	doi = {10.1021/es401014b},
	pages = {7982--7988},
	number = {14},
	journaltitle = {Environmental Science \& Technology},
	author = {Jin, Ling and Gaus, Caroline and van Mourik, Louise and Escher, Beate I.},
	urldate = {2017-02-01},
	date = {2013-07-16},
	langid = {english},
	file = {es401014b.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\4RK7CX8S\\es401014b.pdf:application/pdf}
}

@article{allan_vivo_2013,
	title = {In Vivo Passive Sampling of Nonpolar Contaminants in Brown Trout ( \textit{Salmo trutta} )},
	volume = {47},
	issn = {0013-936X, 1520-5851},
	url = {http://pubs.acs.org/doi/abs/10.1021/es401810r},
	doi = {10.1021/es401810r},
	pages = {11660--11667},
	number = {20},
	journaltitle = {Environmental Science \& Technology},
	author = {Allan, Ian John and Bæk, Kine and Haugen, Thrond Oddvar and Hawley, Kate Louise and Høgfeldt, Andreas Sven and Lillicrap, Adam David},
	urldate = {2017-02-01},
	date = {2013-10-15},
	langid = {english},
	file = {es401810r.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\A2PHM5M2\\es401810r.pdf:application/pdf}
}

@article{oconnell_vivo_2015,
	title = {In vivo contaminant partitioning to silicone implants: Implications for use in biomonitoring and body burden},
	volume = {85},
	issn = {01604120},
	url = {http://linkinghub.elsevier.com/retrieve/pii/S0160412015300568},
	doi = {10.1016/j.envint.2015.09.016},
	shorttitle = {In vivo contaminant partitioning to silicone implants},
	pages = {182--188},
	journaltitle = {Environment International},
	author = {O'Connell, Steven G. and Kerkvliet, Nancy I. and Carozza, Susan and Rohlman, Diana and Pennington, Jamie and Anderson, Kim A.},
	urldate = {2017-02-01},
	date = {2015-12},
	langid = {english},
	file = {1-s2.0-S0160412015300568-main.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\4NMWDP8E\\1-s2.0-S0160412015300568-main.pdf:application/pdf}
}

@article{xu_application_2016-1,
	title = {Application of in vivo solid-phase microextraction in environmental analysis},
	volume = {85},
	issn = {01659936},
	url = {http://linkinghub.elsevier.com/retrieve/pii/S0165993616300152},
	doi = {10.1016/j.trac.2016.03.003},
	pages = {26--35},
	journaltitle = {{TrAC} Trends in Analytical Chemistry},
	author = {Xu, Jianqiao and Chen, Guosheng and Huang, Shuyao and Qiu, Junlang and Jiang, Ruifen and Zhu, Fang and Ouyang, Gangfeng},
	urldate = {2017-02-01},
	date = {2016-12},
	langid = {english},
	file = {1-s2.0-S0165993616300152-main.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\WFRJUPCW\\1-s2.0-S0165993616300152-main.pdf:application/pdf}
}

@article{durig_new_2016,
	title = {New Polymer Passive Sampler for Sensitive Biomonitoring of Lipid-Rich Matrices},
	volume = {3},
	issn = {2328-8930, 2328-8930},
	url = {http://pubs.acs.org/doi/abs/10.1021/acs.estlett.5b00333},
	doi = {10.1021/acs.estlett.5b00333},
	pages = {52--56},
	number = {2},
	journaltitle = {Environmental Science \& Technology Letters},
	author = {Dürig, Wiebke and Blakey, Idriss and Grant, Sharon and Chambers, Lewis and Escher, Beate I. and Weijs, Liesbeth and Gaus, Caroline},
	urldate = {2017-02-01},
	date = {2016-02-09},
	langid = {english},
	file = {acs%2Eestlett%2E5b00333.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\9RBURA46\\acs%2Eestlett%2E5b00333.pdf:application/pdf}
}

@incollection{jahnke_combining_2015,
	location = {Berlin, Heidelberg},
	title = {Combining Passive Sampling with Toxicological Characterization of Complex Mixtures of Pollutants from the Aquatic Environment},
	url = {http://link.springer.com/10.1007/10_2015_5014},
	publisher = {Springer Berlin Heidelberg},
	author = {Jahnke, Annika and Witt, Gesine and Schäfer, Sabine and Haase, Nora and Escher, Beate I.},
	urldate = {2017-02-01},
	date = {2015},
	doi = {10.1007/10_2015_5014},
	file = {chp%3A10.1007%2F10_2015_5014.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\B88VIEBZ\\chp%3A10.1007%2F10_2015_5014.pdf:application/pdf}
}

@article{sigmundsson_determination_2002,
	title = {Determination of Active Concentrations and Association and Dissociation Rate Constants of Interacting Biomolecules:  An Analytical Solution to the Theory for Kinetic and Mass Transport Limitations in Biosensor Technology and Its Experimental Verification},
	volume = {41},
	issn = {0006-2960},
	url = {http://dx.doi.org/10.1021/bi020099h},
	doi = {10.1021/bi020099h},
	shorttitle = {Determination of Active Concentrations and Association and Dissociation Rate Constants of Interacting Biomolecules},
	abstract = {Accurate determination of kinetic rate constants for interacting biomolecules requires knowledge of the active concentrations of the participating molecules. Also, in other biomedical and clinical applications, sensitive, precise and accurate methods are needed to determine the concentration of biologically active molecules, which frequently constitute only a fraction of the total molecular pool. Here we report a novel development of the approach to determining active concentrations based on surface plasmon resonance ({SPR}) technology. The method relies on changes in binding rates with varying flow rates under conditions of partial mass transport, and does not require standards of known concentrations, given that the molecular mass of the molecule of interest is known. We introduce an analytical solution to the differential equations describing the formation of a 1:1 bimolecular complex, taking into account both the association and dissociation reactions, under partial mass transport limitations. This solution can be used in global fitting to binding curves obtained at different flow rates. The accuracy, precision, and sensitivity of this approach were determined in experiments involving binding of tyrosine-phosphorylated recombinant proteins to anti-phosphotyrosine antibodies, where the active concentration could be determined independently by in vitro phosphorylation with 33P. There was an excellent agreement between the active concentrations determined by the analytical {SPR}-based method and by determination of the level of radioactivity of the phosphorylated protein. The {SPR}-based method allows determination of protein concentrations at picomolar levels. A procedure for accurate determinations of association and dissociation rate constants, based on the analytical solution of the mass transport and binding theory, is outlined.},
	pages = {8263--8276},
	number = {26},
	journaltitle = {Biochemistry},
	shortjournal = {Biochemistry},
	author = {Sigmundsson, Kristmundur and Másson, Gísli and Rice, Richard and Beauchemin, Nicole and Öbrink, Björn},
	urldate = {2017-02-01},
	date = {2002-07-01},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\HQSKZQRT\\bi020099h.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\TRKNUDUP\\Sigmundsson et al. - 2002 - Determination of Active Concentrations and Associa.pdf:application/pdf}
}

@article{myszka_extending_1998,
	title = {Extending the range of rate constants available from {BIACORE}: interpreting mass transport-influenced binding data.},
	volume = {75},
	issn = {0006-3495},
	url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1299734/},
	shorttitle = {Extending the range of rate constants available from {BIACORE}},
	abstract = {Surface-based binding assays are often influenced by the transport of analyte to the sensor surface. Using simulated data sets, we test a simple two-compartment model to see if its description of transport and binding is sufficient to accurately analyze {BIACORE} data. First we present a computer model that can generate realistic {BIACORE} data. This model calculates the laminar flow of analyte within the flow cell, its diffusion both perpendicular and parallel to the sensor surface, and the reversible chemical reaction between analyte and immobilized reactant. We use this computer model to generate binding data under a variety of conditions. An analysis of these data sets with the two-compartment model demonstrates that good estimates of the intrinsic reaction rate constants are recovered even when mass transport influences the binding reaction. We also discuss the conditions under which the two-compartment model can be used to determine the diffusion coefficient of the analyte. Our results illustrate that this model can significantly extend the range of association rate constants that can be accurately determined from {BIACORE}.},
	pages = {583--594},
	number = {2},
	journaltitle = {Biophysical Journal},
	shortjournal = {Biophys J},
	author = {Myszka, D G and He, X and Dembo, M and Morton, T A and Goldstein, B},
	urldate = {2017-02-01},
	date = {1998-08},
	pmid = {9675161},
	pmcid = {PMC1299734},
	file = {PubMed Central Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\DHTGBJ48\\Myszka et al. - 1998 - Extending the range of rate constants available fr.pdf:application/pdf}
}

@article{grover_shah_calibration-free_2015,
	title = {Calibration-free concentration analysis of protein biomarkers in human serum using surface plasmon resonance},
	volume = {144},
	issn = {0039-9140},
	url = {https://www.sciencedirect.com/science/article/pii/S0039914015301120},
	doi = {10.1016/j.talanta.2015.06.074},
	abstract = {In complex biological samples such as serum, determination of specific and active concentration of target proteins, independent of a calibration curve, will be valuable in many applications. Calibration-free concentration analysis ({CFCA}) is a surface plasmon resonance ({SPR})-based label-free approach, which calculates active concentration of proteins using their known diffusion coefficient and observed changes in binding rates at different flow rates under diffusion-limited conditions. Here, for the first time we demonstrate the application of {CFCA} for determining protein biomarker abundance, specifically serum amyloid A ({SAA}), directly in the serum samples of patients suffering from different infectious and non-infectious diseases. The assay involves preparation of appropriate reaction surfaces by immobilizing antibodies on {CM}5 chips via amine coupling followed by serum sample preparation and injection over activated and reference surfaces at flow-rates of 5 and 100 μL/min. The system was validated in healthy and diseased (infectious and non-infectious) serum samples by quantifying two different proteins: β2-microglobulin (β2M) and {SAA}. All concentration assays were performed for nearly 100 serum samples, which showed reliable quantification in unattended runs with high accuracy and sensitivity. The method could detect the serum β2M to as low as 13 ng/{mL} in 1000-fold serum dilution, indicating the possible utility of this approach to detect low abundance protein biomarkers in body fluids. Applying the {CFCA} approach, significant difference in serum abundance of {SAA} was identified in diseased subjects as compared to the healthy controls, which correlated well with our previous proteomic investigations. Estimation of {SAA} concentration for a subset of healthy and diseased sera was also performed using {ELISA}, and the trend was observed to be similar in both {SPR} assay and {ELISA}. The reproducibility of {CFCA} in various serum samples made the interpretation of assay simple and reliable. This study illustrates a significant step forward in rapid monitoring of several protein markers in serum samples, with utility in biomarker validation and other therapeutic applications.},
	pages = {801--808},
	journaltitle = {Talanta},
	shortjournal = {Talanta},
	author = {Grover Shah, Veenita and Ray, Sandipan and Karlsson, Robert and Srivastava, Sanjeeva},
	urldate = {2017-02-01},
	date = {2015-11-01},
	keywords = {Serum, Active concentration, Calibration-free concentration analysis, Label-free detection, Serum amyloid A, Surface plasmon resonance},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\33V95PWU\\S0039914015301120.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\XXDFPH75\\Grover Shah et al. - 2015 - Calibration-free concentration analysis of protein.pdf:application/pdf}
}

@article{karlsson_biosensor_2016,
	title = {Biosensor binding data and its applicability to the determination of active concentration},
	volume = {8},
	issn = {1867-2450, 1867-2469},
	url = {http://link.springer.com/article/10.1007/s12551-016-0219-5},
	doi = {10.1007/s12551-016-0219-5},
	abstract = {Protein concentration data are required for understanding protein interactions and are a prerequisite for the determination of affinity and kinetic properties. It is vital for the judgment of protein quality and for monitoring the effect of therapeutic agents. Protein concentration values are typically obtained by comparison to a standard and derived from a standard curve. The use of a protein standard is convenient, but may not give reliable results if samples and standards behave differently. In other cases, a standard preparation may not be available and has to be established and validated. Using surface plasmon resonance ({SPR}) biosensors, an alternative concentration method is possible. This method is called calibration-free concentration analysis ({CFCA}); it generates active concentration data directly and without the use of a standard. The active concentration of a protein is defined through its interaction with its binding partner. This concentration can differ from the total protein concentration if some protein fraction is incapable of binding. If a protein has several different binding sites, active concentration data can be established for each binding site using site-specific interaction partners. This review will focus on {CFCA} analysis. It will reiterate the theory of {CFCA} and describe how {CFCA} has been applied in different research segments. The major part of the review will, however, try to set expectations on {CFCA} and discuss how {CFCA} can be further developed for absolute and relative concentration measurements.},
	pages = {347--358},
	number = {4},
	journaltitle = {Biophysical Reviews},
	shortjournal = {Biophys Rev},
	author = {Karlsson, Robert},
	urldate = {2017-02-01},
	date = {2016-12-01},
	langid = {english},
	file = {Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\348UHKJB\\10.html:text/html;Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\5U4TIHKF\\Karlsson - 2016 - Biosensor binding data and its applicability to th.pdf:application/pdf}
}

@article{rupert_methods_2017,
	title = {Methods for the physical characterization and quantification of extracellular vesicles in biological samples},
	volume = {1861},
	issn = {0304-4165},
	url = {https://www.sciencedirect.com/science/article/pii/S0304416516302756},
	doi = {10.1016/j.bbagen.2016.07.028},
	abstract = {Background
Our body fluids contain a multitude of cell-derived vesicles, secreted by most cell types, commonly referred to as extracellular vesicles. They have attracted considerable attention for their function as intercellular communication vehicles in a broad range of physiological processes and pathological conditions. Extracellular vesicles and especially the smallest type, exosomes, have also generated a lot of excitement in view of their potential as disease biomarkers or as carriers for drug delivery. In this context, state-of-the-art techniques capable of comprehensively characterizing vesicles in biological fluids are urgently needed.
Scope of review
This review presents the arsenal of techniques available for quantification and characterization of physical properties of extracellular vesicles, summarizes their working principles, discusses their advantages and limitations and further illustrates their implementation in extracellular vesicle research.
Major conclusions
The small size and physicochemical heterogeneity of extracellular vesicles make their physical characterization and quantification an extremely challenging task. Currently, structure, size, buoyant density, optical properties and zeta potential have most commonly been studied. The concentration of vesicles in suspension can be expressed in terms of biomolecular or particle content depending on the method at hand. In addition, common quantification methods may either provide a direct quantitative measurement of vesicle concentration or solely allow for relative comparison between samples.
General significance
The combination of complementary methods capable of detecting, characterizing and quantifying extracellular vesicles at a single particle level promises to provide new exciting insights into their modes of action and to reveal the existence of vesicle subpopulations fulfilling key biological tasks.},
	pages = {3164--3179},
	number = {1},
	journaltitle = {Biochimica et Biophysica Acta ({BBA}) - General Subjects},
	shortjournal = {Biochimica et Biophysica Acta ({BBA}) - General Subjects},
	author = {Rupert, Déborah L. M. and Claudio, Virginia and Lässer, Cecilia and Bally, Marta},
	urldate = {2017-02-01},
	date = {2017-01},
	keywords = {Quantification, Exosomes, Extracellular vesicles, Analytical methods, Characterization, Physical properties},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\PKH6PCPD\\S0304416516302756.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\RMQTFIKP\\Rupert et al. - 2017 - Methods for the physical characterization and quan.pdf:application/pdf}
}

@online{noauthor_methods_nodate,
	title = {Methods for the physical characterization and quantification of extracellular vesicles in biological samples},
	url = {http://www.sciencedirect.com/science/article/pii/S0304416516302756},
	urldate = {2017-02-01},
	file = {Methods for the physical characterization and quantification of extracellular vesicles in biological samples:C\:\\Users\\nazmula\\Zotero\\storage\\WN9CA2IM\\S0304416516302756.html:text/html}
}

@article{karlsson_analysis_1993,
	title = {Analysis of active antibody concentration. Separation of affinity and concentration parameters},
	volume = {166},
	issn = {0022-1759},
	url = {http://www.sciencedirect.com/science/article/pii/002217599390330A},
	doi = {10.1016/0022-1759(93)90330-A},
	abstract = {Antibody binding to surfaces with differing amounts of immobilised antigen was measured in a biosensor system using surface plasmon resonance detection. Binding rates obtained during the initial binding phase on high density antigen surfaces were proportional to antibody concentration and independent of antigen-antibody affinity. One antibody calibration curve covering the range from 0.5 to 160 {nM} (0.08–25 μg/ml) antibody was valid for {IgG} antibodies with different antigen specificities. To illustrate the use of this methodology active antibody concentrations were analysed in culture media and in rabbit serum.},
	pages = {75--84},
	number = {1},
	journaltitle = {Journal of Immunological Methods},
	shortjournal = {Journal of Immunological Methods},
	author = {Karlsson, Robert and Fägerstam, Lars and Nilshans, Helena and Persson, Björn},
	urldate = {2017-02-01},
	date = {1993-11-05},
	keywords = {Mass transfer, (Antibody), Affinity, Concentration},
	file = {1-s2.0-002217599390330A-main.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\KM52Q9K8\\1-s2.0-002217599390330A-main.pdf:application/pdf;ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\UVCH4RC9\\002217599390330A.html:text/html}
}

@article{pol_evaluation_2016,
	title = {Evaluation of calibration-free concentration analysis provided by Biacore™ systems},
	volume = {510},
	issn = {0003-2697},
	url = {https://www.sciencedirect.com/science/article/pii/S0003269716301762},
	doi = {10.1016/j.ab.2016.07.009},
	abstract = {Surface Plasmon Resonance biosensors measure the interaction between a molecule in solution and its interaction partner attached to a sensor surface. Under certain conditions, the observed binding rate can be used directly to obtain the concentration of the molecule in solution, without the use of any standard. This type of assay is referred to as Calibration Free Concentration Analysis, {CFCA}. By examining experimental conditions, including immobilization levels and temperature, for a range of analytes, and by using global analysis of several sample dilutions, conditions that gave the most robust results were identified. These conditions provided the concentration values that were on average ∼15\% lower than those obtained using other methods. The accuracy of the concentration determined may be related to how the analyte is distributed in the dextran matrix and to its distance from the gold surface, and may thereby depend on the conversion of the {SPR} signal to mass. A good precision of {CFCA}, ∼8\% (n = 21), was demonstrated when this method was used to efficiently guide purification procedures of Interferon α-2a. In this paper, the theory behind {CFCA} and the future developments, as well as the application of {CFCA} for absolute and relative concentration measurements (including the assessment of the potency of a biotherapeutic medicine) are discussed, and new evaluation tools that broaden the range of applications, are introduced.},
	pages = {88--97},
	journaltitle = {Analytical Biochemistry},
	shortjournal = {Analytical Biochemistry},
	author = {Pol, Ewa and Roos, Håkan and Markey, Francis and Elwinger, Fredrik and Shaw, Alan and Karlsson, Robert},
	urldate = {2017-02-01},
	date = {2016-10-01},
	keywords = {Biacore, Biosimilar, {CFCA}, {SPR}},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\5TQSU6KJ\\S0003269716301762.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\XEZ5IDKN\\Pol et al. - 2016 - Evaluation of calibration-free concentration analy.pdf:application/pdf}
}

@online{noauthor_evaluation_nodate,
	title = {Evaluation of calibration-free concentration analysis provided by Biacore™ systems},
	url = {http://www.sciencedirect.com/science/article/pii/S0003269716301762},
	urldate = {2017-02-01},
	file = {Evaluation of calibration-free concentration analysis provided by Biacore™ systems:C\:\\Users\\nazmula\\Zotero\\storage\\S8FMJTRE\\S0003269716301762.html:text/html}
}

@article{helmerhorst_real-time_2012,
	title = {Real-time and Label-free Bio-sensing of Molecular Interactions by Surface Plasmon Resonance: A Laboratory Medicine Perspective},
	volume = {33},
	issn = {0159-8090},
	url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529553/},
	shorttitle = {Real-time and Label-free Bio-sensing of Molecular Interactions by Surface Plasmon Resonance},
	abstract = {Radioactive, chromogenic, fluorescent and other labels have long provided the basis of detection systems for biomolecular interactions including immunoassays and receptor binding studies. However there has been unprecedented growth in a number of powerful label free biosensor technologies over the last decade. While largely at the proof-of-concept stage in terms of clinical applications, the development of more accessible platforms may see surface plasmon resonance ({SPR}) emerge as one of the most powerful optical detection platforms for the real-time monitoring of biomolecular interactions in a label-free environment., In this review, we provide an overview of {SPR} principles and current and future capabilities in a diagnostic context, including its application for monitoring a wide range of molecular markers of disease. The advantages and pitfalls of using {SPR} to study biomolecular interactions are discussed, with particular emphasis on its potential to differentiate subspecies of analytes and the inherent ability for quantitation through calibration-free concentration analysis ({CFCA}). In addition, recent advances in multiplex applications, high throughput arrays, miniaturisation, and enhancements using noble metal nanoparticles that promise unprecedented sensitivity to the level of single molecule detection, are discussed., In summary, while {SPR} is not a new technique, technological advances may see {SPR} quickly emerge as a highly powerful technology, enabling rapid and routine analysis of molecular interactions for a diverse range of targets, including those with clinical applicability. As the technology produces data quickly, in real-time and in a label-free environment, it may well have a significant presence in future developments in lab-on-a-chip technologies including point-of-care devices and personalised medicine.},
	pages = {161--173},
	number = {4},
	journaltitle = {The Clinical Biochemist Reviews},
	shortjournal = {Clin Biochem Rev},
	author = {Helmerhorst, Erik and Chandler, David J and Nussio, Matt and Mamotte, Cyril D},
	urldate = {2017-02-01},
	date = {2012-11},
	pmid = {23267248},
	pmcid = {PMC3529553},
	file = {PubMed Central Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\BW7AKX9Z\\Helmerhorst et al. - 2012 - Real-time and Label-free Bio-sensing of Molecular .pdf:application/pdf}
}

@article{imamura_calibration-free_2017,
	title = {Calibration-free concentration analysis for an analyte prone to self-association},
	volume = {516},
	issn = {0003-2697},
	url = {https://www.sciencedirect.com/science/article/pii/S0003269716303499},
	doi = {10.1016/j.ab.2016.10.013},
	abstract = {Calibration-free concentration analysis ({CFCA}) based on surface plasmon resonance uses the diffusion coefficient of an analyte to determine the concentration of that analyte in a bulk solution. In general, {CFCA} is avoided when investigating analytes prone to self-association, as the heterogeneous diffusion coefficient results in a loss of precision. The derivation for self-association of the analyte was presented here. By using the diffusion coefficient for the monomeric state, {CFCA} provides the lowest possible concentration even though the analyte is self-associated.},
	pages = {61--64},
	journaltitle = {Analytical Biochemistry},
	shortjournal = {Analytical Biochemistry},
	author = {Imamura, Hiroshi and Honda, Shinya},
	urldate = {2017-02-01},
	date = {2017-01-01},
	keywords = {Calibration-free concentration analysis, Surface plasmon resonance, Aggregation, Self-association},
	file = {ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\CKW2SKDB\\Imamura and Honda - 2017 - Calibration-free concentration analysis for an ana.pdf:application/pdf;ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\IAD6UTQR\\S0003269716303499.html:text/html}
}

@article{kottegoda_demonstration_2002,
	title = {Demonstration of low flow push–pull perfusion},
	volume = {121},
	issn = {0165-0270},
	url = {https://www.sciencedirect.com/science/article/pii/S0165027002002455},
	doi = {10.1016/S0165-0270(02)00245-5},
	abstract = {Methods to follow in vivo chemical composition provide information regarding the processes of intercellular communication. There is a need for methods that provide chemical information from small volumes of the central nervous system ({CNS}) without sacrificing neurochemical recovery. One method that offers potential for providing such information is push–pull perfusion. In this study a low flow push–pull perfusion system is introduced that provides high (70–80\%) in vitro recoveries. A concentric probe design is used with a 27-gauge stainless steel outer cannula for saline infusion and an inner fused silica capillary for fluid withdrawal. Flow rates of 10–50 nl/min were reliably generated and were well matched in vitro. Sampling was performed in the striatum of an anesthetized rat generating a 0.5 μl sample every 12 min. Capillary electrophoresis was used to determine glutamate levels in each sample; the basal level was found to be 1.97±0.70 μM. The method described was also demonstrated to deliver l-trans-pyrrolidine-2,4-dicarboxylic acid through the perfusion solution while sampling. Post-sampling histological analysis demonstrates little tissue disturbance to the sampled region. These data provide evidence that low flow push–pull method is a viable alternative for studying neurochemical signaling in the {CNS}.},
	pages = {93--101},
	number = {1},
	journaltitle = {Journal of Neuroscience Methods},
	shortjournal = {Journal of Neuroscience Methods},
	author = {Kottegoda, Sumith and Shaik, Imtiazuddin and Shippy, Scott A},
	urldate = {2017-02-01},
	date = {2002-11-15},
	keywords = {In vivo sampling, Capillary electrophoresis, Glutamate, l-trans-Pyrrolidine-2,4-dicarboxylic acid, Laser-induced fluorescence, Push–pull perfusion, Striatum},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\R86RGEWG\\S0165027002002455.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\8AE738A8\\Kottegoda et al. - 2002 - Demonstration of low flow push–pull perfusion.pdf:application/pdf}
}

@article{poole_glossary_2016,
	title = {Glossary of terms used in extraction ({IUPAC} Recommendations 2016)},
	volume = {88},
	issn = {0033-4545},
	url = {https://www.degruyter.com/view/j/pac.2016.88.issue-5/pac-2015-0903/pac-2015-0903.xml},
	doi = {10.1515/pac-2015-0903},
	abstract = {Approaches for analytical-scale extraction are developing rapidly as new strategies are implemented to improve sample throughput, to minimize material use in laboratory methods, and to develop on-site capabilities. In this contribution, definitions and recommendations for symbols for the terms used in analytical extraction are presented. Exhaustive, microextraction, elevated temperature, microwave- and ultrasound-assisted, parallel batch, flow through systems, and membrane extraction approaches are discussed. An associated tutorial titled “Extraction” provides a detailed introduction to the topic.},
	pages = {517--558},
	number = {5},
	journaltitle = {Pure and Applied Chemistry},
	author = {Poole, Colin and Mester, Zoltan and Miró, Manuel and Pedersen-Bjergaard, Stig and Pawliszyn, Janusz},
	urldate = {2017-01-31},
	date = {2016},
	file = {Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\N5N58MPD\\Poole et al. - 2016 - Glossary of terms used in extraction (IUPAC Recomm.pdf:application/pdf}
}

@article{schuck_role_2010,
	title = {The Role of Mass Transport Limitation and Surface Heterogeneity in the Biophysical Characterization of Macromolecular Binding Processes by {SPR} Biosensing},
	volume = {627},
	issn = {1064-3745},
	url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134667/},
	doi = {10.1007/978-1-60761-670-2_2},
	abstract = {This chapter presents an introduction to the kinetic analysis of {SPR} biosensor data for the determination of affinity and kinetic rate constants of biomolecular interactions between an immobilized and a soluble binding partner. The need to be aware of and critically tests the assumptions underlying the analysis models is emphasized and the consequences for the experimental design are discussed. The two most common sources of deviation in {SPR} surface binding kinetics from the ideal pseudo-first order binding kinetics of bimolecular reactions are mass transport limitations and the heterogeneity of the surface sites. These problems are intrinsic to the use of a biosensor surface for characterizing interactions. The effect of these factors on the observed binding kinetics, and strategies to account for them are reviewed, both in the context of mathematical data analysis, as well as the design of the experiments and controls.},
	pages = {15--54},
	journaltitle = {Methods in molecular biology (Clifton, N.J.)},
	shortjournal = {Methods Mol Biol},
	author = {Schuck, Peter and Zhao, Huaying},
	urldate = {2017-01-31},
	date = {2010},
	pmid = {20217612},
	pmcid = {PMC4134667},
	file = {PubMed Central Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\E3NRG4Q5\\Schuck and Zhao - 2010 - The Role of Mass Transport Limitation and Surface .pdf:application/pdf}
}

@article{mei_multiple_2014,
	title = {Multiple monolithic fiber solid-phase microextraction: A new extraction approach for aqueous samples},
	volume = {1345},
	issn = {0021-9673},
	url = {https://www.sciencedirect.com/science/article/pii/S0021967314005810},
	doi = {10.1016/j.chroma.2014.04.029},
	shorttitle = {Multiple monolithic fiber solid-phase microextraction},
	abstract = {A novel multiple monolithic fiber solid-phase microextraction ({MMF}-{SPME}) was designed and prepared. Two steps were involved in the preparation of {MMF}-{SPME}. Firstly, single thin fiber (0.5 mm in diameter) was prepared by co-polymerization of vinylimidazole and ethylene dimethacrylate. Secondly, several thin fibers were bound together to obtain the {MMF} assembly. The extraction and desorption dynamics of {MMF}-{SPME} with different numbers of fibers were studied in detail. In order to demonstrate the usability of the new {MMF}-{SPME}, the extraction performance of {MMF}-{SPME} for 2-chlorophenol, 2,4-dichlorophenol, 2,4,6-trichlorophenol and pentachlorophenol was investigated in direct {SPME} mode. Results indicated that aqueous samples could form convection effectively within {MMF}-{SPME} because there were gaps between fibers. The extraction procedure was accelerated by the convection. At the same time, the {MMF}-{SPME} possessed high extraction capacity because more sorbent was employed. Under the optimized extraction conditions, low detection limits (S/N = 3) and quantification limits (S/N = 10) for the target analytes were achieved within the range of 0.13–0.29 μg/L and 0.44–0.98 μg/L, respectively. The {MMF}-{SPME} also showed a very long lifespan and good repeatability. Finally, the {MMF}-{SPME} was successfully applied to the analysis of tap, lake and ground water samples with spiked recoveries in the range of 73.8–101\%.},
	pages = {29--36},
	journaltitle = {Journal of Chromatography A},
	shortjournal = {Journal of Chromatography A},
	author = {Mei, Meng and Huang, Xiaojia and Yuan, Dongxing},
	urldate = {2017-01-30},
	date = {2014-06-06},
	keywords = {Chlorophenols, Monoliths, Multiple monolithic fiber solid-phase microextraction ({MMF}-{SPME}), Solid-phase extraction, Sorbents},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\ZR2EZ55B\\S0021967314005810.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\PBSP496C\\Mei et al. - 2014 - Multiple monolithic fiber solid-phase microextract.pdf:application/pdf}
}

@article{mehdinia_enhancing_2008,
	title = {Enhancing extraction rate in solid-phase microextraction by using nano-structured polyaniline coating},
	volume = {31},
	issn = {1615-9314},
	url = {http://onlinelibrary.wiley.com/doi/10.1002/jssc.200800284/abstract},
	doi = {10.1002/jssc.200800284},
	abstract = {The decrement of equilibrium extraction time without losing extraction efficiency in solid-phase microextraction ({SPME}) was achieved using nano-structured coating. Polyaniline ({PANI}) was used as an extraction phase for the comparison of extraction capacity and equilibrium extraction time of nano- and micro-structured coatings. Polychlorinated biphenyls ({PCBs}) were used as model compounds to examine the extraction properties of nano- and micro-structured coatings. The results revealed that nano-structured {PANI} coating showed higher extraction rate and shorter desorption time than micro-structured coating, because of the larger surface area. In order to evaluate the extraction capability of prepared nano-structured {PANI} coating, headspace-{SPME} method was used for the determination of {PCBs} in sediment samples by {GC}-electron capture detector. The proposed method was validated using the certified reference material.},
	pages = {3565--3572},
	number = {20},
	journaltitle = {Journal of Separation Science},
	shortjournal = {J. Sep. Science},
	author = {Mehdinia, Ali and Fazlollah Mousavi, Mir},
	urldate = {2017-01-30},
	date = {2008-10-01},
	langid = {english},
	keywords = {Solid-phase microextraction, Nano-structure, Polyaniline, Polychlorinated biphenyls},
	file = {Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\RSETE5IB\\Mehdinia and Fazlollah Mousavi - 2008 - Enhancing extraction rate in solid-phase microextr.pdf:application/pdf;Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\RTIGPTCR\\abstract.html:text/html}
}

@article{mehdinia_enhancing_2008-1,
	title = {Enhancing extraction rate in solid-phase microextraction by using nano-structured polyaniline coating},
	volume = {31},
	issn = {1615-9314},
	doi = {10.1002/jssc.200800284},
	abstract = {The decrement of equilibrium extraction time without losing extraction efficiency in solid-phase microextraction ({SPME}) was achieved using nano-structured coating. Polyaniline ({PANI}) was used as an extraction phase for the comparison of extraction capacity and equilibrium extraction time of nano- and micro-structured coatings. Polychlorinated biphenyls ({PCBs}) were used as model compounds to examine the extraction properties of nano- and micro-structured coatings. The results revealed that nano-structured {PANI} coating showed higher extraction rate and shorter desorption time than micro-structured coating, because of the larger surface area. In order to evaluate the extraction capability of prepared nano-structured {PANI} coating, headspace-{SPME} method was used for the determination of {PCBs} in sediment samples by {GC}-electron capture detector. The proposed method was validated using the certified reference material.},
	pages = {3565--3572},
	number = {20},
	journaltitle = {Journal of Separation Science},
	shortjournal = {J Sep Sci},
	author = {Mehdinia, Ali and Mousavi, Mir Fazlollah},
	date = {2008-10},
	pmid = {18850634}
}

@article{plecis_ionic_2011,
	title = {Ionic and mass transport in micro-nanofluidic devices: a matter of volumic surface charge},
	volume = {11},
	issn = {1473-0189},
	url = {http://pubs.rsc.org/en/content/articlelanding/2011/lc/c0lc00079e},
	doi = {10.1039/C0LC00079E},
	shorttitle = {Ionic and mass transport in micro-nanofluidic devices},
	abstract = {The shape and the surface charge of microchannels are critical parameters for ionic and mass transport in microfluidic systems. A great number of studies and developments have been carried out in order to optimize these features separately. We propose to consider them together within a new fundamental parameter for microfluidics, that we named the Volumic Surface Charge ({VSC}), which is the ratio of the surface charge to the section height in planar microchannels. The non-linear effects induced by rapid {VSC} variations can result in selective preconcentration processes, which can be used for a simultaneous preconcentration and separation of biomolecules within simple straight channels. In this review, we first present 3 different techniques that we developed to tune the {VSC} either by surface chemical patterning, integration of polarisable interfaces or geometrical constrictions. The proof of concept of the selective preconcentration using {VSC} variations will be presented on the basis of experimental results obtained with fluorescent probes and numerical simulations.},
	pages = {795--804},
	number = {5},
	author = {Plecis, Adrien and Pallandre, Antoine and Haghiri-Gosnet, Anne-Marie},
	urldate = {2017-01-30},
	date = {2011-03-07},
	langid = {english},
	file = {Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\I58ZSDSA\\c0lc00079e.html:text/html;Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\RWVQPMGU\\Plecis et al. - 2011 - Ionic and mass transport in micro-nanofluidic devi.pdf:application/pdf}
}

@article{liu_mesoporous_2015,
	title = {Mesoporous {TiO}2 nanoparticles for highly sensitive solid-phase microextraction of organochlorine pesticides},
	volume = {878},
	issn = {0003-2670},
	url = {https://www.sciencedirect.com/science/article/pii/S0003267015004468},
	doi = {10.1016/j.aca.2015.03.054},
	abstract = {Mesoporous {TiO}2 nanoparticles were synthesized with the hydrothermal method and characterized by powder X-ray diffraction ({PXRD}) and transmission electron microscope ({TEM}). Then a superior solid-phase microextraction ({SPME}) fiber was fabricated by sequentially coating the stainless steel fiber with silicone sealant film and mesoporous {TiO}2 powder. The developed fiber possessed a homogeneous surface and a long life-span up to 100 times at direct immersing ({DI}) extraction mode. Under the optimized conditions, the extraction efficiencies of the self-made 17 μm {TiO}2 fiber for six organochlorine pesticides ({OCPs}) were higher than those of the two commercial fibers (65 μm {PDMS}/{DVB} and 85 μm {PA} fibers) which were much thicker than the former. As for analytical performance, low detection limits (0.08–0.60 ng L−1) and wide linearity (5–5000 ng L−1) were achieved under the optimal conditions. The repeatabilities (n = 5) for single fiber were between 2.8 and 12.3\%, while the reproducibilities (n = 3) of fiber-to-fiber were in the range of 3.7–15.7\%. The proposed fiber was successfully applied to the sensitive analysis of {OCPs} in real water samples and four of the six analytes were detected from the rainwater and the lake water samples.},
	pages = {109--117},
	journaltitle = {Analytica Chimica Acta},
	shortjournal = {Analytica Chimica Acta},
	author = {Liu, Shuqin and Xie, Lijun and Zheng, Juan and Jiang, Ruifeng and Zhu, Fang and Luan, Tiangang and Ouyang, Gangfeng},
	urldate = {2017-01-30},
	date = {2015-06-09},
	keywords = {Solid-phase microextraction, Gas chromatography–mass spectrometry, Mesoporous {TiO}2 nanoparticles, Organochlorine pesticides},
	file = {ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\2TI53GC8\\Liu et al. - 2015 - Mesoporous TiO2 nanoparticles for highly sensitive.pdf:application/pdf;ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\C8CDKUCW\\S0003267015004468.html:text/html}
}

@article{xia_preparation_2001,
	title = {Preparation and Characterization of Porous Silica-Coated Multifibers for Solid-Phase Microextraction},
	volume = {73},
	issn = {0003-2700},
	url = {http://dx.doi.org/10.1021/ac001273f},
	doi = {10.1021/ac001273f},
	abstract = {C18-bonded silica-coated multifibers were prepared and studied as a stationary phase for solid-phase microextraction ({SPME}). The porous multifiber {SPME} provided larger absorption capacity and higher absorption rate compared to a polymer-coated single fiber. Its absorption rate was 10 times higher than that of a commercial 100-μm poly(dimethylsiloxane) ({PDMS})-coated fiber. Its high extraction efficiency enabled the positive identification of unknown compounds at sub-part-per-billion level in full-scan mode with a benchtop quadruple {GC}/{MS}. The desorption temperature indicated that the analyte interactions with the C18-bonded silica were stronger than those with the {PDMS} polymer. The dependence of the equilibration time on the molecular weight was not observed for the porous multifiber {SPME}. The boundary layer between the fiber coating and the sample matrix could be the absorption control step in {SPME} under mild agitation. The special experimental conditions in the porous multifiber {SPME}, such as air interference and polar organic solvent wetting, were investigated.},
	pages = {2041--2047},
	number = {9},
	journaltitle = {Analytical Chemistry},
	shortjournal = {Anal. Chem.},
	author = {Xia, Xin-Rui and Leidy, Ross B.},
	urldate = {2017-01-30},
	date = {2001-05-01},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\7JEEB7JU\\ac001273f.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\ER7ZFGD2\\Xia and Leidy - 2001 - Preparation and Characterization of Porous Silica-.pdf:application/pdf}
}

@article{gomez-rios_open_2017,
	title = {Open Port Probe Sampling Interface for the Direct Coupling of Biocompatible Solid-Phase Microextraction to Atmospheric Pressure Ionization Mass Spectrometry},
	volume = {89},
	issn = {0003-2700},
	url = {http://dx.doi.org/10.1021/acs.analchem.6b04737},
	doi = {10.1021/acs.analchem.6b04737},
	abstract = {In recent years, the direct coupling of solid phase microextraction ({SPME}) and mass spectrometry ({MS}) has shown its great potential to improve limits of quantitation, accelerate analysis throughput, and diminish potential matrix effects when compared to direct injection to {MS}. In this study, we introduce the open port probe ({OPP}) as a robust interface to couple biocompatible {SPME} (Bio-{SPME}) fibers to {MS} systems for direct electrospray ionization. The presented design consisted of minimal alterations to the front-end of the instrument and provided better sensitivity, simplicity, speed, wider compound coverage, and high-throughput in comparison to the {LC}–{MS} based approach. Quantitative determination of clenbuterol, fentanyl, and buprenorphine was successfully achieved in human urine. Despite the use of short extraction/desorption times (5 min/5 s), limits of quantitation below the minimum required performance levels ({MRPL}) set by the world antidoping agency ({WADA}) were obtained with good accuracy (≥90\%) and linearity (R2 {\textgreater} 0.99) over the range evaluated for all analytes using sample volumes of 300 μL. In-line technologies such as multiple reaction monitoring with multistage fragmentation ({MRM}3) and differential mobility spectrometry ({DMS}) were used to enhance the selectivity of the method without compromising analysis speed. On the basis of calculations, once coupled to high throughput, this method can potentially yield preparation times as low as 15 s per sample based on the 96-well plate format. Our results demonstrated that Bio-{SPME}-{OPP}-{MS} efficiently integrates sampling/sample cleanup and atmospheric pressure ionization, making it an advantageous configuration for several bioanalytical applications, including doping in sports, in vivo tissue sampling, and therapeutic drug monitoring.},
	pages = {3805--3809},
	number = {7},
	journaltitle = {Analytical Chemistry},
	shortjournal = {Anal. Chem.},
	author = {Gómez-Ríos, Germán Augusto and Liu, Chang and Tascon, Marcos and Reyes-Garcés, Nathaly and Arnold, Don W. and Covey, Thomas R. and Pawliszyn, Janusz},
	urldate = {2017-04-23},
	date = {2017-04-04},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\Z5FUWRGK\\acs.analchem.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\TXHQG2FN\\Gómez-Ríos et al. - 2017 - Open Port Probe Sampling Interface for the Direct .pdf:application/pdf}
}

@article{lukic_evolution_2017,
	title = {Evolution of free and bound volatile aroma compounds and phenols during fermentation of Muscat blanc grape juice with and without skins},
	volume = {232},
	issn = {0308-8146},
	doi = {10.1016/j.foodchem.2017.03.166},
	abstract = {Recently, various technologies which utilise fermentation with skins have been developed for obtaining distinct white wines. This study first reports the dynamic changes of volatiles and phenols that occur during skin fermentation in white winemaking. Volatiles were analysed by solid-phase extraction ({SPE}), solid-phase microextraction ({SPME}) and gas chromatography ({GC}), and phenols by ultra-performance liquid chromatography ({UPLC}), both with mass spectrometric detection. Monoterpenols increased during the first 3 days of skin fermentation, after which certain glycosides decreased, but were higher than in control. The presence of skins reduced ho-trienol, β-damascenone, acids and esters. After a 1–3 days lag phase, skin fermentation caused a constant increase of most phenols. It was estimated that skin fermentation up to 1–3 days might be beneficial for monoterpenol varietal aroma, which should be re-evaluated through further studies. Longer durations promoted phenol extraction more strongly, which is possibly suitable for obtaining more distinct wines or blending components. © 2017 Elsevier Ltd},
	pages = {25--35},
	journaltitle = {Food Chemistry},
	author = {Lukić, I. and Lotti, C. and Vrhovsek, U.},
	date = {2017},
	keywords = {Evolution, Fermentation with skins, Monoterpenes, Phenols, Varietal aroma},
	file = {SCOPUS Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\RSMIKHVD\\display.html:text/html}
}

@online{noauthor_rapid_nodate,
	title = {Rapid detection of five anesthetics in tilapias by in vivo solid phase microextraction coupling with gas chromatography-mass spectrometry},
	url = {http://www.sciencedirect.com/science/article/pii/S0039914017303454},
	urldate = {2017-04-22},
	file = {Rapid detection of five anesthetics in tilapias by in vivo solid phase microextraction coupling with gas chromatography-mass spectrometry:C\:\\Users\\nazmula\\Zotero\\storage\\SQDKZM27\\S0039914017303454.html:text/html}
}

@article{de_grazia_new_2017-2,
	title = {A new and efficient Solid Phase Microextraction approach for analysis of high fat content food samples using a matrix-compatible coating},
	volume = {167},
	issn = {0039-9140},
	url = {http://www.sciencedirect.com/science/article/pii/S0039914017301741},
	doi = {10.1016/j.talanta.2017.01.064},
	abstract = {The current work presents the optimization of a protocol enabling direct extraction of avocado samples by a new Solid Phase Microextraction matrix compatible coating. In order to further extend the coating life time, pre-desorption and post-desorption washing steps were optimized for solvent type, time, and degree of agitation employed. Using optimized conditions, lifetime profiles of the coating related to extraction of a group of analytes bearing different physical-chemical properties were obtained. Over 80 successive extractions were carried out to establish coating efficiency using {PDMS}/{DVB} 65 µm commercial coating in comparison with the {PDMS}/{DVB}/{PDMS}. The {PDMS}/{DVB} coating was more prone to irreversible matrix attachment on its surface, with consequent reduction of its extractive performance after 80 consecutive extractions. Conversely, the {PDMS}/{DVB}/{PDMS} coating showed enhanced inertness towards matrix fouling due to its outer smooth {PDMS} layer. This work represents the first step towards the development of robust {SPME} methods for quantification of contaminants in avocado as well as other fatty-based matrices, with minimal sample pre-treatment prior to extraction. In addition, an evaluation of matrix components attachment on the coating surface and related artifacts created by desorption of the coating at high temperatures in the {GC}-injector port, has been performed by {GCxGC}-{ToF}/{MS}.},
	pages = {754--760},
	journaltitle = {Talanta},
	shortjournal = {Talanta},
	author = {De Grazia, Selenia and Gionfriddo, Emanuela and Pawliszyn, Janusz},
	urldate = {2017-04-22},
	date = {2017-05-15},
	keywords = {Avocado, Direct immersion, Extended lifetime, Matrix-compatible {SPME} coating, {PDMS}/{DVB}/{PDMS}},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\7ENH5GQ8\\S0039914017301741.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\K72BUUW4\\De Grazia et al. - 2017 - A new and efficient Solid Phase Microextraction ap.pdf:application/pdf}
}

@article{sajid_porous_2017,
	title = {Porous membrane protected micro-solid-phase extraction: A review of features, advancements and applications},
	volume = {965},
	issn = {0003-2670},
	url = {http://www.sciencedirect.com/science/article/pii/S0003267017302404},
	doi = {10.1016/j.aca.2017.02.023},
	shorttitle = {Porous membrane protected micro-solid-phase extraction},
	abstract = {Membrane protected micro-solid-phase extraction (μ-{SPE}) was introduced in 2006 as an alternative to multistep {SPE}. μ-{SPE} is based on packing of very small amount of sorbent inside the porous membrane sheet whose edges are heat sealed to fabricate a μ-{SPE} device. This device performs clean up, extraction, and pre-concentration in a single step. It suits best for extraction of complex samples as sorbent is effectively protected inside the membrane and extraneous matter cannot adsorb over it. This review summarizes most important aspects of μ-{SPE} including basic principles, extraction procedure, different formats, sorbents employed and affecting parameters. The article also provides a brief account on modified μ-{SPE} procedures where μ-{SPE} was either combined with other techniques or some major changes were introduced in original procedure. Finally, the applications of μ-{SPE} in environmental, food and biological analysis are described. At the end, advantages and pitfalls of μ-{SPE} are critically appraised.},
	pages = {36--53},
	journaltitle = {Analytica Chimica Acta},
	shortjournal = {Analytica Chimica Acta},
	author = {Sajid, Muhammad},
	urldate = {2017-04-22},
	date = {2017-05-01},
	keywords = {Sample preparation, Biological analysis, Microextraction, Environmental analysis, Food analysis, Membrane protected micro-solid-phase extraction},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\KDARVW8D\\S0003267017302404.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\CSZPUTIJ\\Sajid - 2017 - Porous membrane protected micro-solid-phase extrac.pdf:application/pdf}
}

@article{trujillo-rodriguez_vacuum-assisted_2017-1,
	title = {Vacuum-assisted headspace-solid phase microextraction for determining volatile free fatty acids and phenols. Investigations on the effect of pressure on competitive adsorption phenomena in a multicomponent system},
	volume = {962},
	issn = {0003-2670},
	url = {http://www.sciencedirect.com/science/article/pii/S0003267017301472},
	doi = {10.1016/j.aca.2017.01.056},
	abstract = {This work proposes a new vacuum headspace solid-phase microextraction (Vac-{HSSPME}) method combined to gas chromatography-flame ionization detection for the determination of free fatty acids ({FFAs}) and phenols. All target analytes of the multicomponent solution were volatiles but their low Henry's Law constants rendered them amenable to Vac-{HSSPME}. The ability of a new and easy to construct Vac-{HSSPME} sampler to maintain low-pressure conditions for extended sampling times was concurrently demonstrated. Vac-{HSSPME} and regular {HSSPME} methods were independently optimized and the results were compared at all times. The performances of four commercial {SPME} fibers and two polymeric ionic liquid ({PIL})-based {SPME} fibers were evaluated and the best overall results were obtained with the adsorbent-type {CAR}/{PDMS} fiber. For the concentrations used here, competitive displacement became more intense for the smaller and more volatile analytes of the multi-component solution when lowering the sampling pressure. The extraction time profiles showed that Vac-{HSSPME} had a dramatic positive effect on extraction kinetics. The local maxima of adsorbed analytes recorded with Vac-{HSSPME} occurred faster, but were always lower than that with regular {HSSPME} due to the faster analyte-loading from the multicomponent solution. Increasing the sampling temperature during Vac-{HSSPME} reduced the extraction efficiency of smaller analytes due to the enhancement in water molecule collisions with the fiber. This effect was not recorded for the larger phenolic compounds. Based on the optimum values selected, Vac-{HSSPME} required a shorter extraction time and milder sampling conditions than regular {HSSPME}: 20 min and 35 °C for Vac-{HSSPME} versus 40 min and 45 °C for regular {HSSPME}. The performance of the optimized Vac-{HSSPME} and regular {HSSPME} procedures were assessed and Vac-{HSSPME} method proved to be more sensitive, with lower limits of detection (from 0.14 to 13 μg L−1), and better intra-day precision (relative standard deviations values \< 10\% at the lowest spiked level) than regular {HSSPME} for almost all target analytes. The proposed Vac-{HSSPME} method was successfully applied to quantify {FFAs} and phenols in milk and milk derivatives samples.},
	pages = {41--51},
	journaltitle = {Analytica Chimica Acta},
	shortjournal = {Analytica Chimica Acta},
	author = {Trujillo-Rodríguez, María J. and Pino, Verónica and Psillakis, Elefteria and Anderson, Jared L. and Ayala, Juan H. and Yiantzi, Evangelia and Afonso, Ana M.},
	urldate = {2017-04-22},
	date = {2017-04-15},
	keywords = {gas chromatography, headspace solid-phase microextraction, Phenols, Milk samples, Vacuum-assisted headspace solid-phase microextraction, Volatile free fatty acids},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\23BKQ6WC\\S0003267017301472.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\Q9T5BT7E\\Trujillo-Rodríguez et al. - 2017 - Vacuum-assisted headspace-solid phase microextract.pdf:application/pdf}
}

@article{maraval_quantification_2010,
	title = {Quantification of 2-acetyl-1-pyrroline in rice by stable isotope dilution assay through headspace solid-phase microextraction coupled to gas chromatography–tandem mass spectrometry},
	volume = {675},
	issn = {0003-2670},
	url = {http://www.sciencedirect.com/science/article/pii/S0003267010008913},
	doi = {10.1016/j.aca.2010.07.024},
	abstract = {A new and convenient synthesis of 2-acetyl-1-pyrroline (2AP), a potent flavor compound in rice, and its ring-deuterated analog, 2-acetyl-1-d2-pyrroline (2AP-d2), was reported. A stable isotope dilution assay ({SIDA}), involving headspace solid-phase microextraction ({HS}-{SPME}) combined with gas chromatography–positive chemical ionization-ion trap-tandem mass spectrometry ({GC}–{PCI}-{IT}-{MS}–{MS}), was developed for 2AP quantification. A divinylbenzene/carboxen/polydimethylsiloxane ({DVB}/{CAR}/{PDMS}) fiber was used for {HS}-{SPME} procedure and parameters affecting analytes recovery, such as extraction time and temperature, {pH} and salt, were studied. The repeatability of the method (n = 10) expressed as relative standard deviation ({RSD}) was 11.6\%. A good linearity was observed from 5.9 to 779 ng of 2AP (r2 = 0.9989). Limits of detection ({LOD}) and quantification ({LOQ}) for 2AP were 0.1 and 0.4 ng g−1 of rice, respectively. The recovery of spiked 2AP from rice matrix was almost complete. The developed method was applied to the quantification of 2AP in aerial parts and grains of scented and non-scented rice cultivars.},
	pages = {148--155},
	number = {2},
	journaltitle = {Analytica Chimica Acta},
	shortjournal = {Analytica Chimica Acta},
	author = {Maraval, Isabelle and Sen, Kemal and Agrebi, Abdelhamid and Menut, Chantal and Morere, Alain and Boulanger, Renaud and Gay, Frédéric and Mestres, Christian and Gunata, Ziya},
	urldate = {2017-04-22},
	date = {2010-08-24},
	keywords = {{HS}-{SPME}, 2-Acetyl-1-pyrroline, Convenient synthesis, {GC}–{MS}–{MS}, Rice, {SIDA}},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\RJVP8EBH\\S0003267010008913.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\9NRZWVE7\\Maraval et al. - 2010 - Quantification of 2-acetyl-1-pyrroline in rice by .pdf:application/pdf}
}

@article{san_stable_2017,
	title = {Stable isotope dilution assay ({SIDA}) and {HS}-{SPME}-{GCMS} quantification of key aroma volatiles for fruit and sap of Australian mango cultivars},
	volume = {221},
	issn = {0308-8146},
	url = {http://www.sciencedirect.com/science/article/pii/S0308814616319793},
	doi = {10.1016/j.foodchem.2016.11.130},
	abstract = {Reported herein is a high throughput method to quantify in a single analysis the key volatiles that contribute to the aroma of commercially significant mango cultivars grown in Australia. The method constitutes stable isotope dilution analysis ({SIDA}) in conjunction with headspace ({HS}) solid-phase microextraction ({SPME}) coupled with gas-chromatography mass spectrometry ({GCMS}). Deuterium labelled analogues of the target analytes were either purchased commercially or synthesised for use as internal standards. Seven volatiles, hexanal, 3-carene, α-terpinene, p-cymene, limonene, α-terpinolene and ethyl octanoate, were targeted. The resulting calibration functions had determination coefficients (R2) ranging from 0.93775 to 0.99741. High recovery efficiencies for spiked mango samples were also achieved. The method was applied to identify the key aroma volatile compounds produced by ‘Kensington Pride’ and ‘B74’ mango fruit and by ‘Honey Gold’ mango sap. This method represents a marked improvement over current methods for detecting and measuring concentrations of mango fruit and sap volatiles.},
	pages = {613--619},
	journaltitle = {Food Chemistry},
	shortjournal = {Food Chemistry},
	author = {San, Anh T. and Joyce, Daryl C. and Hofman, Peter J. and Macnish, Andrew J. and Webb, Richard I. and Matovic, Nicolas J. and Williams, Craig M. and De Voss, James J. and Wong, Siew H. and Smyth, Heather E.},
	urldate = {2017-04-22},
	date = {2017-04-15},
	keywords = {Volatiles, Gas chromatography–mass spectrometry ({GC}–{MS}), Mangifera indica, Mango fruit, Solid-phase microextraction ({SPME}), Stable-isotope dilution assay ({SIDA})},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\M8KKZ98W\\S0308814616319793.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\BDH9C4M7\\San et al. - 2017 - Stable isotope dilution assay (SIDA) and HS-SPME-G.pdf:application/pdf}
}

@article{wang_chip-based_2016,
	title = {Chip-Based Magnetic Solid-Phase Microextraction Online Coupled with {MicroHPLC}–{ICPMS} for the Determination of Mercury Species in Cells},
	volume = {88},
	issn = {0003-2700},
	url = {http://dx.doi.org/10.1021/acs.analchem.5b03130},
	doi = {10.1021/acs.analchem.5b03130},
	abstract = {Trace mercury speciation in cells is critical to understand its cytotoxicity and cell protection mechanism. In this work, we fabricated a chip-based magnetic solid-phase microextraction ({MSPME}) system, integrating a cell lysis unit as well as a sample extraction unit, and online combined it with micro high-performance liquid chromatography ({microHPLC})–inductively coupled plasma mass spectrometry ({ICPMS}) for the speciation of mercury in {HepG}2 cells. Magnetic nanoparticles with sulfhydryl functional group were synthesized and self-assembled in the microchannels for the preconcentration of mercury species in cells under an external magnetic field. The enrichment factors are ca. 10-fold, and the recoveries for the spiked samples are in the range of 98.3–106.5\%. The developed method was used to analyze target mercury species in Hg2+ or {MeHg}+ incubated {HepG}2 cells. The results demonstrated that {MeHg}+ entered into the {HepG}2 cells more easily than Hg2+, and part of the {MeHg}+ might demethylate into Hg2+ in {HepG}2 cells. Besides, comprehensive speciation of mercury in incubated cells revealed different detoxification mechanisms of Hg2+ and {MeHg}+ in Hg2+ or {MeHg}+ incubated {HepG}2 cells.},
	pages = {796--802},
	number = {1},
	journaltitle = {Analytical Chemistry},
	shortjournal = {Anal. Chem.},
	author = {Wang, Han and Chen, Beibei and Zhu, Siqi and Yu, Xiaoxiao and He, Man and Hu, Bin},
	urldate = {2017-04-22},
	date = {2016-01-05},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\NNSZBM38\\acs.analchem.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\IJKIRP2G\\Wang et al. - 2016 - Chip-Based Magnetic Solid-Phase Microextraction On.pdf:application/pdf}
}

@article{vasconcelos_magnetic_2017,
	title = {Magnetic solid phase extraction for determination of drugs in biological matrices},
	volume = {89},
	issn = {0165-9936},
	url = {http://www.sciencedirect.com/science/article/pii/S0165993616302795},
	doi = {10.1016/j.trac.2016.11.011},
	abstract = {Determination of drugs in biological matrices is required in different contexts, including development of new drug products, bioequivalence and pharmacokinetic studies, toxicological analysis and therapeutic drug monitoring. The presence of endogenous compounds and the analytes low concentration make biological matrices complex to be analyzed. Therefore, sample preparation is an important step. In this context, new extraction techniques have been proposed in recent years. An innovative approach is magnetic solid phase extraction, a new type of solid phase extraction based on magnetic sorbents. This technique has been increasingly studied for determination of drugs in biological matrices due to several advantages over conventional techniques and the development of new materials. Owing to the potential of this approach, the literature was reviewed in order to evaluate the development and application of this technique comprising the period from 2009 to September 2016. Critical evaluation and trends regarding magnetic solid phase extraction were presented.},
	pages = {41--52},
	journaltitle = {{TrAC} Trends in Analytical Chemistry},
	shortjournal = {{TrAC} Trends in Analytical Chemistry},
	author = {Vasconcelos, Ingrid and Fernandes, Christian},
	urldate = {2017-04-22},
	date = {2017-04},
	keywords = {Biological fluids, Carbon nanotubes, Drugs, Magnetic solid phase extraction, Magnetite nanoparticles},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\U5KVBVJK\\S0165993616302795.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\X242FPDB\\Vasconcelos and Fernandes - 2017 - Magnetic solid phase extraction for determination .pdf:application/pdf}
}

@article{sagandykova_determination_2017,
	title = {Determination of semi-volatile additives in wines using {SPME} and {GC}–{MS}},
	volume = {220},
	issn = {0308-8146},
	url = {http://www.sciencedirect.com/science/article/pii/S0308814616315631},
	doi = {10.1016/j.foodchem.2016.09.164},
	abstract = {Parameters of headspace solid-phase microextraction, such as fiber coating (85 μm {CAR}/{PDMS}), extraction time (2 min for white and 3 min for red wines), temperature (85 °C), pre-incubation time (15 min) were optimized for identification and quantification of semi-volatile additives (propylene glycol, sorbic and benzoic acids) in wines. To overcome problems in their determination, an evaporation of the wine matrix was performed. Using the optimized method, screening of 25 wine samples was performed, and the presence of propylene glycol, sorbic and benzoic acids was found in 22, 20 and 6 samples, respectively. Analysis of different wines using a standard addition approach showed good linearity in concentration ranges 0–250, 0–125, and 0–250 mg/L for propylene glycol, sorbic and benzoic acids, respectively. The proposed method can be recommended for quality control of wine and disclosing adulterated samples.},
	pages = {162--167},
	journaltitle = {Food Chemistry},
	shortjournal = {Food Chemistry},
	author = {Sagandykova, Gulyaim N. and Alimzhanova, Mereke B. and Nurzhanova, Yenglik T. and Kenessov, Bulat},
	urldate = {2017-04-22},
	date = {2017-04-01},
	keywords = {Solid-phase microextraction, Mass spectrometry, gas chromatography, Adulteration, Semi-volatile additives, Wine},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\MW7ZGXNF\\S0308814616315631.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\PBCSISM9\\Sagandykova et al. - 2017 - Determination of semi-volatile additives in wines .pdf:application/pdf}
}

@article{cai_comparison_2015,
	title = {Comparison of two thin-film microextractions for the analysis of estrogens in aqueous tea extract and environmental water samples by high performance liquid chromatography-ultraviolet detection},
	volume = {173},
	issn = {0308-8146},
	url = {http://www.sciencedirect.com/science/article/pii/S0308814614017270},
	doi = {10.1016/j.foodchem.2014.11.002},
	abstract = {Two thin-film microextractions ({TFME}), octadecylsilane ({ODS})-polyacrylonitrile ({PAN})-{TFME} and polar enhanced phase ({PEP})-{PAN}-{TFME} have been proposed for the analysis of bisphenol-A, diethylstilbestrol and 17β-estradiol in aqueous tea extract and environmental water samples followed by high performance liquid chromatography-ultraviolet detection. Both thin-films were prepared by spraying. The influencing factors including {pH}, extraction time, desorption solvent, desorption volume, desorption time, ion strength and reusability were investigated. Under the optimal conditions, the two {TFME} methods are similar in terms of the analytical performance evaluated by standard addition method. The limits of detection for three estrogens in environmental water and aqueous tea extract matrix ranged from 1.3 to 1.6 and 2.8 to 7.1 ng {mL}−1 by the two {TFME} methods, respectively. Both approaches were applied for the analysis of analytes in real aqueous tea extract and environmental water samples, presenting satisfactory recoveries ranged from 87.3\% to 109.4\% for the spiked samples.},
	pages = {1158--1166},
	journaltitle = {Food Chemistry},
	shortjournal = {Food Chemistry},
	author = {Cai, Pei-Shan and Li, Dan and Chen, Jing and Xiong, Chao-Mei and Ruan, Jin-Lan},
	urldate = {2017-04-22},
	date = {2015-04-15},
	keywords = {Estrogens, Octadecylsilane sorbent, Polar enhanced phase sorbent, Polyacrylonitrile, Thin-film microextraction},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\TZ34MVMK\\S0308814614017270.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\8PMHRA5I\\Cai et al. - 2015 - Comparison of two thin-film microextractions for t.pdf:application/pdf}
}

@article{souza-silva_methodical_2016,
	title = {Methodical evaluation and improvement of matrix compatible {PDMS}-overcoated coating for direct immersion solid phase microextraction gas chromatography ({DI}-{SPME}-{GC})-based applications},
	volume = {920},
	issn = {0003-2670},
	url = {http://www.sciencedirect.com/science/article/pii/S0003267016303324},
	doi = {10.1016/j.aca.2016.03.015},
	abstract = {The main quest for the implementation of direct {SPME} to complex matrices has been the development of matrix compatible coatings that provide sufficient sensitivity towards the target analytes. In this context, we present here a thorough evaluation of {PDMS}-overcoated fibers suitable for simultaneous extraction of different polarities analytes, while maintaining adequate matrix compatibility. For this, eleven analytes were selected, from various application classes (pesticides, industrial chemicals and pharmaceuticals) and with a wide range of log P values (ranging from 1.43 to 6). The model matrix chosen was commercial Concord grape juice, which is rich in pigments such as anthocyanins, and contains approximately 20\% of sugar (w/w). Two types of {PDMS}, as well as other intrinsic factors associated with the {PDMS}-overcoated fiber fabrication are studied. The evaluation showed that the {PDMS}-overcoated fibers considerably slowed down the coating fouling process during direct immersion in complex matrices of high sugar content. Longevity differences could be seen between the two types of {PDMS} tested, with a proprietary Sylgard® giving superior performance because of lesser amount of reactive groups and enhanced hydrophobicity. Conversely, the thickness of the outer layer did not seem to have a significant effect on the fiber lifetime. We also demonstrate that the uniformity of the overcoated {PDMS} layer is paramount to the achievement of reliable data and extended fiber lifetime. Employing the optimum overcoated fiber, limits of detection ({LOD}) in the range of 0.2–1.3 ng/g could be achieved. Additional improvement is attainable by introducing washing of the coatings after desorption, so that any carbon build-up (fouling) left on the coating surface after thermal desorption can be removed.},
	pages = {54--62},
	journaltitle = {Analytica Chimica Acta},
	shortjournal = {Analytica Chimica Acta},
	author = {Souza-Silva, Érica A. and Gionfriddo, Emanuela and Shirey, Robert and Sidisky, Len and Pawliszyn, Janusz},
	urldate = {2017-04-22},
	date = {2016-05-12},
	keywords = {Food analysis, Solid-phase microextraction ({SPME}), Coatings, Gas chromatography ({GC}), Matrix-compatible, Pesticides residues},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\C6ICHM2N\\S0003267016303324.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\7HFVGE4Q\\Souza-Silva et al. - 2016 - Methodical evaluation and improvement of matrix co.pdf:application/pdf}
}

@article{li_preparation_2016,
	title = {Preparation of magnetic {ODS}-{PAN} thin-films for microextraction of quetiapine and clozapine in plasma and urine samples followed by {HPLC}-{UV} detection},
	volume = {125},
	issn = {0731-7085},
	url = {http://www.sciencedirect.com/science/article/pii/S0731708516301923},
	doi = {10.1016/j.jpba.2016.04.006},
	abstract = {In this study, conventional thin-film microextraction ({TFME}) was endowed with magnetic by introducing superparamagnetic {SiO}2@Fe3O4 nanoparticles in thin-films. Novel magnetic octadecylsilane ({ODS})-polyacrylonitrile ({PAN}) thin-films were prepared by spraying, and used for the microextraction of quetiapine and clozapine in plasma and urine samples, followed by the detection of {HPLC}-{UV}. The influencing factors on the extraction efficiency of magnetic {ODS}-{PAN} {TFME}, including {pH}, extraction time, desorption solvent, desorption time, and ion strength were investigated systematically. Under the optimal conditions, both analytes showed good linearity over ranges of 0.070–9.000 μg {mL}−1 and 0.012–9.000 μg {mL}−1 in plasma and urine samples, respectively, with correlation coefficients (R2) above 0.9990. Limits of detection ({LODs}) for quetiapine in plasma and urine samples were 0.013 and 0.003 μg {mL}−1, respectively. {LODs} for clozapine in plasma and urine samples were 0.015 and 0.003 μg {mL}−1, respectively. The relative standard deviations ({RSDs}) for quetiapine and clozapine were less than 9.23\%. After the validation, the protocol was successfully applied for the determination of quetiapine and clozapine in patients’ plasma and urine samples with satisfactory recoveries between 99–110\%. The proposed magnetic {ODS}-{PAN} {TFME} was very simple, fast and easy to handle. It showed high potential as a powerful pretreatment technology for routine therapeutic drug monitoring ({TDM}) in plasma and urine samples.},
	pages = {319--328},
	journaltitle = {Journal of Pharmaceutical and Biomedical Analysis},
	shortjournal = {Journal of Pharmaceutical and Biomedical Analysis},
	author = {Li, Dan and Zou, Juan and Cai, Pei-Shan and Xiong, Chao-Mei and Ruan, Jin-Lan},
	urldate = {2017-04-22},
	date = {2016-06-05},
	keywords = {Clozapine, {HPLC}-{UV}, Magnetic octadecylsilane-polyacrylonitrile thin-film microextraction ({ODS}-{PAN} {TFME}), Plasma, Quetiapine, Therapeutic drug monitoring ({TDM}), Urine},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\EEHHU725\\S0731708516301923.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\KHBKSFEA\\Li et al. - 2016 - Preparation of magnetic ODS-PAN thin-films for mic.pdf:application/pdf}
}

@article{mirnaghi_automated_2013,
	title = {Automated determination of phenolic compounds in wine, berry, and grape samples using 96-blade solid phase microextraction system coupled with liquid chromatography–tandem mass spectrometry},
	volume = {1276},
	issn = {0021-9673},
	url = {http://www.sciencedirect.com/science/article/pii/S0021967312019309},
	doi = {10.1016/j.chroma.2012.12.043},
	abstract = {An automated 96-thin-film solid phase microextraction system was optimized for high throughput analysis of phenolic compounds in wine, berry, and grape samples. Liquid chromatography and tandem mass spectrometry methods were optimized and applied for separation and detection of compounds. Evaluation of five different stationary phases showed that polystyrene-divinylbenzene-polyacrylonitrile ({PS}-{DVB}-{PAN}) is the optimum extraction phase for the extraction of phenolic compounds under study. The thin-film {PS}-{DVB}-{PAN} {SPME} coating provided almost exhaustive extraction recovery for all phenolics compounds under study, except for naringenin with 80\% recovery. Extraction efficiency, inter- and intra-day reproducibility, sensitivity, linearity, limit of detection and quantitation, and matrix effect were evaluated. Intra-day and inter-day reproducibility were in the respective range of 4–8 and 7–13\% relative standard deviation ({RSD}) for all eight phenolic compounds. Limits of detection and quantitation of the proposed {SPME}-{LC}–{MS}/{MS} system for the analysis of analytes under study were found in the range of 0.2–3 and 0.5–10 ng/{mL}, respectively. Standard addition calibration was applied for the quantitative determination of unknown phenolic compounds from wine, berry, and grape samples. The assessment of matrix effect showed significant reduction of ion suppression/enhancement using {SPME} method in comparison with that of solvent extraction technique.},
	pages = {12--19},
	journaltitle = {Journal of Chromatography A},
	shortjournal = {Journal of Chromatography A},
	author = {Mirnaghi, Fatemeh S. and Mousavi, Fatemeh and Rocha, Sílvia M. and Pawliszyn, Janusz},
	urldate = {2017-04-22},
	date = {2013-02-08},
	keywords = {Standard addition calibration},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\X48HETRB\\S0021967312019309.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\FNPT8T9J\\Mirnaghi et al. - 2013 - Automated determination of phenolic compounds in w.pdf:application/pdf}
}

@article{sagandykova_determination_2017-1,
	title = {Determination of semi-volatile additives in wines using {SPME} and {GC}–{MS}},
	volume = {220},
	issn = {0308-8146},
	url = {http://www.sciencedirect.com/science/article/pii/S0308814616315631},
	doi = {10.1016/j.foodchem.2016.09.164},
	abstract = {Parameters of headspace solid-phase microextraction, such as fiber coating (85 μm {CAR}/{PDMS}), extraction time (2 min for white and 3 min for red wines), temperature (85 °C), pre-incubation time (15 min) were optimized for identification and quantification of semi-volatile additives (propylene glycol, sorbic and benzoic acids) in wines. To overcome problems in their determination, an evaporation of the wine matrix was performed. Using the optimized method, screening of 25 wine samples was performed, and the presence of propylene glycol, sorbic and benzoic acids was found in 22, 20 and 6 samples, respectively. Analysis of different wines using a standard addition approach showed good linearity in concentration ranges 0–250, 0–125, and 0–250 mg/L for propylene glycol, sorbic and benzoic acids, respectively. The proposed method can be recommended for quality control of wine and disclosing adulterated samples.},
	pages = {162--167},
	journaltitle = {Food Chemistry},
	shortjournal = {Food Chemistry},
	author = {Sagandykova, Gulyaim N. and Alimzhanova, Mereke B. and Nurzhanova, Yenglik T. and Kenessov, Bulat},
	urldate = {2017-04-22},
	date = {2017-04-01},
	keywords = {Standard addition calibration},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\ZJERC4PP\\S0308814616315631.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\V54BPKW5\\Sagandykova et al. - 2017 - Determination of semi-volatile additives in wines .pdf:application/pdf}
}

@article{sagandykova_determination_2017-2,
	title = {Determination of semi-volatile additives in wines using {SPME} and {GC}–{MS}},
	volume = {220},
	issn = {0308-8146},
	doi = {10.1016/j.foodchem.2016.09.164},
	abstract = {Parameters of headspace solid-phase microextraction, such as fiber coating (85 μm {CAR}/{PDMS}), extraction time (2 min for white and 3 min for red wines), temperature (85 °C), pre-incubation time (15 min) were optimized for identification and quantification of semi-volatile additives (propylene glycol, sorbic and benzoic acids) in wines. To overcome problems in their determination, an evaporation of the wine matrix was performed. Using the optimized method, screening of 25 wine samples was performed, and the presence of propylene glycol, sorbic and benzoic acids was found in 22, 20 and 6 samples, respectively. Analysis of different wines using a standard addition approach showed good linearity in concentration ranges 0–250, 0–125, and 0–250 mg/L for propylene glycol, sorbic and benzoic acids, respectively. The proposed method can be recommended for quality control of wine and disclosing adulterated samples. © 2016 Elsevier Ltd},
	pages = {162--167},
	journaltitle = {Food Chemistry},
	author = {Sagandykova, G.N. and Alimzhanova, M.B. and Nurzhanova, Y.T. and Kenessov, B.},
	date = {2017},
	keywords = {Solid-phase microextraction, Mass spectrometry, gas chromatography, Adulteration, Semi-volatile additives, Wine},
	file = {SCOPUS Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\IAGKMW98\\display.html:text/html}
}

@article{abdelbary_diazepam-loaded_2009,
	title = {Diazepam-Loaded Solid Lipid Nanoparticles: Design and Characterization},
	volume = {10},
	issn = {1530-9932},
	url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663687/},
	doi = {10.1208/s12249-009-9197-2},
	shorttitle = {Diazepam-Loaded Solid Lipid Nanoparticles},
	abstract = {The aim of the present study was to investigate the feasibility of the inclusion of a water-insoluble drug (diazepam, {DZ}) into solid lipid nanoparticles ({SLNs}), which offer combined advantages of rapid onset and prolonged release of the drug. This work also describes a new approach to prepare suppositories containing {DZ}-loaded {SLN} dispersions, as potential drug carrier for the rectal route. Modified high-shear homogenization and ultrasound techniques were employed to prepare {SLNs}. The effect of incorporation of different concentrations of Compritol® {ATO} 888 or Imwitor® 900K and Poloxamer 188 or Tween 80 was investigated. Results showed that varying the type or concentration of lipid matrix or surfactant had a noticeable influence on the entrapment efficiencies, particle size, and release profiles of prepared {SLNs}. Differential scanning calorimetry and X-ray diffraction measurements showed that the majority of {SLNs} possessed less ordered arrangements of crystals than the corresponding bulk lipids, which was favorable for increasing the drug loading capacity. Transmission electron microscopy and laser diffractometry studies revealed that the prepared nanoparticles were round and homogeneous and 60\% of the formulations were less than 500 nm. Additionally, {SLN} formulations showed significant (P {\textless} 0.05) prolonged release than {DZ} solution. The subsequent step encompassed the preparation and evaluation of {SLN}-based suppositories utilizing {SLN} formulations that illustrated optimal release profiles. The in vitro release of {DZ} from the suppositories prepared using {DZ}-loaded {SLN} dispersions (equivalent to 2 mg {DZ}) was significantly (P {\textless} 0.05) extended compared to suppositories containing 2 mg {DZ} free drug.},
	pages = {211--219},
	number = {1},
	journaltitle = {{AAPS} {PharmSciTech}},
	shortjournal = {{AAPS} {PharmSciTech}},
	author = {Abdelbary, Ghada and Fahmy, Rania H.},
	urldate = {2017-04-19},
	date = {2009-03-10},
	pmid = {19277870},
	pmcid = {PMC2663687},
	file = {PubMed Central Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\PVBS76SN\\Abdelbary and Fahmy - 2009 - Diazepam-Loaded Solid Lipid Nanoparticles Design .pdf:application/pdf}
}

@article{vorum_variation_1993,
	title = {Variation in the binding affinity of warfarin and phenprocoumon to human serum albumin in relation to surgery},
	volume = {44},
	url = {http://www.springerlink.com/index/m3046801019502vv.pdf},
	pages = {157--162},
	number = {2},
	journaltitle = {European journal of clinical pharmacology},
	author = {Vorum, H. and Jørgensen, H. R. I. and Brodersen, R.},
	urldate = {2017-04-19},
	date = {1993},
	file = {art%3A10.1007%2FBF00315474.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\W2KAVQC5\\art%3A10.1007%2FBF00315474.pdf:application/pdf}
}

@article{barber_protein_1978,
	title = {Protein binding of atenolol and propranolol to human serum albumin and in human plasma [proceedings]},
	volume = {6},
	issn = {1365-2125},
	url = {http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.1978.tb04617.x/abstract},
	doi = {10.1111/j.1365-2125.1978.tb04617.x},
	pages = {446P--447P},
	number = {5},
	journaltitle = {British Journal of Clinical Pharmacology},
	shortjournal = {British Journal of Clinical Pharmacology},
	author = {Barber, He and Hawksworth, Gm and Kitteringham, Nr and Petersen, J and Petrie, Jc and Swann, Jm},
	urldate = {2017-04-18},
	date = {1978-11-01},
	langid = {english},
	file = {Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\HSDHZRZ8\\abstract.html:text/html;Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\KSCUGGEE\\Barber et al. - 1978 - Protein binding of atenolol and propranolol to hum.pdf:application/pdf}
}

@article{kwaan_role_2010,
	title = {Role of plasma proteins in whole blood viscosity: a brief clinical review},
	volume = {44},
	issn = {1875-8622},
	doi = {10.3233/CH-2010-1271},
	shorttitle = {Role of plasma proteins in whole blood viscosity},
	abstract = {Whole blood viscosity is affected by a number of factors, among which plasma proteins are a major component. They exert their effects either directly or through their influence on red cell aggregation. Changes in fibrinogen and in immunoglobulins, under both physiologic and pathologic conditions can increase whole blood viscosity. Blood flow through the microvasculature is impaired when viscosity increases, leading to tissue ischemia and a syndrome complex usually referred to as the hyperviscosity syndrome. Abnormalities of fibrinogen greatly increase its ability to cause red cell aggregation, and is a contributory pathogenic factor in ischemic heart disease and stroke. Immunoglobulins may affect blood viscosity directly, or by increasing the red cell aggregation. Changes are seen in many clinical disorders, ranging from inflammatory diseases to plasma cell dyscrasias. The clinical manifestations may be mild and often unnoticed, or they may be life threatening requiring emergency plasmapheresis. Proper management requires a clear understanding of the underlying pathology. When the symptom complex indicates a high probability of the hyperviscosity syndrome, it should lead to early diagnosis and treatment. Therapeutic approaches should include both removing the abnormal plasma protein and treating the primary cause.},
	pages = {167--176},
	number = {3},
	journaltitle = {Clinical Hemorheology and Microcirculation},
	shortjournal = {Clin. Hemorheol. Microcirc.},
	author = {Kwaan, Hau C.},
	date = {2010},
	pmid = {20364062},
	keywords = {Humans, Blood Proteins, Blood Viscosity, Fibrinogen},
	file = {ch%2F2010%2F44-3%2FCH1271.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\2EQG5EEN\\ch%2F2010%2F44-3%2FCH1271.pdf:application/pdf}
}

@article{kesmarky_plasma_2008,
	title = {Plasma viscosity: A forgotten variable},
	volume = {39},
	issn = {1386-0291},
	url = {http://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch1088},
	doi = {10.3233/CH-2008-1088},
	shorttitle = {Plasma viscosity},
	abstract = {Evaluation of plasma viscosity has been underutilized in the clinical practice. Plasma viscosity is determined by water-content and macromolecular components. Plasma is a highly concentrated protein solution, therefore weak protein–protein interactio},
	pages = {243--246},
	number = {1},
	journaltitle = {Clinical Hemorheology and Microcirculation},
	author = {Késmárky, Gábor and Kenyeres, Péter and Rábai, Miklós and Tóth, Kálmán},
	urldate = {2017-04-17},
	date = {2008-01-01},
	file = {Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\Z4P3867D\\ch1088.html:text/html;Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\Q38JKR42\\Késmárky et al. - 2008 - Plasma viscosity A forgotten variable.pdf:application/pdf}
}

@article{reyes-garces_solid_2015,
	title = {Solid Phase Microextraction Devices Prepared on Plastic Support as Potential Single-Use Samplers for Bioanalytical Applications},
	volume = {87},
	issn = {0003-2700, 1520-6882},
	url = {http://pubs.acs.org/doi/10.1021/acs.analchem.5b01849},
	doi = {10.1021/acs.analchem.5b01849},
	pages = {9722--9730},
	number = {19},
	journaltitle = {Analytical Chemistry},
	author = {Reyes-Garcés, Nathaly and Bojko, Barbara and Hein, Dietmar and Pawliszyn, Janusz},
	urldate = {2017-04-17},
	date = {2015-10-06},
	langid = {english},
	file = {acs%2Eanalchem%2E5b01849.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\HWARIDEU\\acs%2Eanalchem%2E5b01849.pdf:application/pdf}
}

@online{noauthor_solid_nodate,
	title = {Solid Phase Microextraction Devices Prepared on Plastic Support as Potential Single-Use Samplers for Bioanalytical Applications - Analytical Chemistry ({ACS} Publications)},
	url = {http://pubs.acs.org/doi/full/10.1021/acs.analchem.5b01849},
	urldate = {2017-04-17},
	file = {Solid Phase Microextraction Devices Prepared on Plastic Support as Potential Single-Use Samplers for Bioanalytical Applications - Analytical Chemistry (ACS Publications):C\:\\Users\\nazmula\\Zotero\\storage\\AK5RMZZE\\acs.analchem.html:text/html}
}

@article{morgan_pharmacokinetics_1986,
	title = {Pharmacokinetics of intravenous and oral salbutamol and its sulphate conjugate.},
	volume = {22},
	issn = {1365-2125},
	url = {http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.1986.tb02939.x/abstract},
	doi = {10.1111/j.1365-2125.1986.tb02939.x},
	abstract = {The pharmacokinetics of salbutamol and its sulphate conjugate metabolite were investigated after intravenous and steady-state oral administration of salbutamol to 10 healthy volunteers. With intravenous administration, total plasma clearance was 480 +/- 123 ml min-1, elimination half-life was 3.86 +/- 0.83 h and apparent volume of distribution was 156 +/- 381. Urinary excretion of unchanged drug and sulphate conjugate were 64.2 +/- 7.1\% and 12.0 +/- 3.1\% of the dose, respectively. With oral administration, systemic availability was 0.50 +/- 0.04, and urinary excretion of unchanged drug and sulphate conjugate were 31.8 +/- 1.9\% and 48.2 +/- 7.3\% of the dose, respectively. The drug eliminated on the first-pass could be accounted for entirely as sulphate conjugate formed, presumably, in the intestinal wall. Renal clearance of salbutamol was 291 +/- 70 ml min-1 after intravenous and 272 +/- 38 ml min-1 after oral administration, while the renal clearance of the sulphate conjugate was 98.5 +/- 23.5 ml min-1 after oral administration. Heart rate increased with increasing plasma salbutamol concentration, although a lag was evident. The effect on heart rate was lower after 24 h continuous oral salbutamol administration.},
	pages = {587--593},
	number = {5},
	journaltitle = {British Journal of Clinical Pharmacology},
	shortjournal = {British Journal of Clinical Pharmacology},
	author = {Morgan, Dj and Paull, Jd and Richmond, Bh and Wilson-Evered, E and Ziccone, Sp},
	urldate = {2017-04-12},
	date = {1986-11-01},
	langid = {english},
	file = {Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\BDQMK33J\\Morgan et al. - 1986 - Pharmacokinetics of intravenous and oral salbutamo.pdf:application/pdf;Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\N826PH33\\abstract.html:text/html}
}

@article{kugel_nanopillars_2014,
	title = {Nanopillars for Sensing},
	volume = {14},
	doi = {10.1166/jnn.2014.9346},
	abstract = {Nanopillars have become a popular area of interest over the past few years because of their large surface area and their unique optical and electronic properties as 1D nano structures. They have proven useful for developing sensing devices. This minireview summarizes the sensing applications of nanopillars based on various sensing platforms.},
	pages = {6469--6477},
	number = {9},
	journaltitle = {Journal of Nanoscience and Nanotechnology},
	shortjournal = {Journal of Nanoscience and Nanotechnology},
	author = {Kugel, Victoria and Ji, Hai-Feng},
	date = {2014-09-01},
	file = {IngentaConnect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\92D59WF5\\Kugel and Ji - 2014 - Nanopillars for Sensing.pdf:application/pdf}
}

@article{anandan_role_2007,
	title = {Role of reaction kinetics and mass transport in glucose sensing with nanopillar array electrodes},
	volume = {1},
	issn = {1754-1611},
	url = {http://dx.doi.org/10.1186/1754-1611-1-5},
	doi = {10.1186/1754-1611-1-5},
	abstract = {The use of nanopillar array electrodes ({NAEs}) for biosensor applications was explored using a combined experimental and simulation approach to characterize the role of reaction kinetics and mass transport in glucose detection with {NAEs}. Thin gold electrodes with arrays of vertically standing gold nanopillars were fabricated and their amperometric current responses were measured under bare and functionalized conditions. Results show that the sensing performances of both the bare and functionalized {NAEs} were affected not only by the presence and variation of the nanoscale structures on the electrodes but also by the reaction kinetics and mass transport of the analyte species involved. These results will shed new light for enhancing the performance of nanostructure based biosensors.},
	pages = {5},
	journaltitle = {Journal of Biological Engineering},
	shortjournal = {Journal of Biological Engineering},
	author = {Anandan, Venkataramani and Yang, Xiaoling and Kim, Euihyeon and Rao, Yeswanth L. and Zhang, Guigen},
	urldate = {2017-04-12},
	date = {2007},
	file = {Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\BB3FXVM9\\Anandan et al. - 2007 - Role of reaction kinetics and mass transport in gl.pdf:application/pdf;Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\H2KHSNXW\\1754-1611-1-5.html:text/html}
}

@article{kelley_advancing_2017,
	title = {Advancing Ultrasensitive Molecular and Cellular Analysis Methods to Speed and Simplify the Diagnosis of Disease},
	volume = {50},
	issn = {0001-4842},
	url = {http://dx.doi.org/10.1021/acs.accounts.6b00497},
	doi = {10.1021/acs.accounts.6b00497},
	abstract = {Diagnosing disease at the molecular level rapidly and with a high level of sensitivity and specificity is a critical capability for modern medicine. Rapid detection of small numbers of biomarkers of early disease in complex, heterogeneous clinical specimens represents a Holy Grail that will have a significant impact on human health.},
	pages = {503--507},
	number = {3},
	journaltitle = {Accounts of Chemical Research},
	shortjournal = {Acc. Chem. Res.},
	author = {Kelley, Shana O.},
	urldate = {2017-04-12},
	date = {2017-03-21},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\G9ASHCZD\\acs.accounts.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\64WURHP4\\Kelley - 2017 - Advancing Ultrasensitive Molecular and Cellular An.pdf:application/pdf}
}

@article{de_luna_high-curvature_2017,
	title = {High-Curvature Nanostructuring Enhances Probe Display for Biomolecular Detection},
	volume = {17},
	issn = {1530-6984, 1530-6992},
	url = {http://pubs.acs.org/doi/abs/10.1021/acs.nanolett.6b05153},
	doi = {10.1021/acs.nanolett.6b05153},
	pages = {1289--1295},
	number = {2},
	journaltitle = {Nano Letters},
	author = {De Luna, Phil and Mahshid, Sahar S. and Das, Jagotamoy and Luan, Binquan and Sargent, Edward H. and Kelley, Shana O. and Zhou, Ruhong},
	urldate = {2017-04-12},
	date = {2017-02-08},
	langid = {english},
	file = {acs%2Enanolett%2E6b05153.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\VN5S9HFB\\acs%2Enanolett%2E6b05153.pdf:application/pdf}
}

@article{bungay_unifying_2011,
	title = {Unifying the mathematical modeling of in vivo and in vitro microdialysis},
	volume = {55},
	issn = {0731-7085},
	url = {http://www.sciencedirect.com/science/article/pii/S0731708511000306},
	doi = {10.1016/j.jpba.2011.01.005},
	abstract = {A unifying approach is presented for developing mathematical models of microdialysis that are applicable to both in vitro and in vivo situations. Previous models for cylindrical probes have been limited by accommodating analyte diffusion through the surrounding medium in the radial direction only, i.e., perpendicular to the probe axis, or by incomplete incorporation of diffusion in the axial direction. Both radial and axial diffusion are included in the present work by employing two-dimensional finite element analysis. As in previous models, the nondimensional clearance modulus (Θ) represents the degree to which analyte clearance from the external medium influences diffusion through the medium for systems exhibiting analyte concentration linearity. Incorporating axial diffusion introduces a second dimensionless group, which is the length-to-radius aspect ratio of the membrane. These two parameter groups uniquely determine the external medium permeability, which is time dependent under transient conditions. At steady-state, the dependence of this permeability on the two groups can be approximated by an algebraic formula for much of the parameter ranges. Explicit steady-state expressions derived for the membrane and fluid permeabilities provide good approximations under transient conditions (quasi-steady-state assumption). The predictive ability of the unifying approach is illustrated for microdialysis of sucrose in vivo (brain) and inert media in vitro, under both well-stirred and quiescent conditions.},
	pages = {54--63},
	number = {1},
	journaltitle = {Journal of Pharmaceutical and Biomedical Analysis},
	shortjournal = {Journal of Pharmaceutical and Biomedical Analysis},
	author = {Bungay, Peter M. and Sumbria, Rachita K. and Bickel, Ulrich},
	urldate = {2017-04-12},
	date = {2011-04-28},
	keywords = {Diffusion, Extraction efficiency, Mathematical model, Microdialysis},
	file = {ScienceDirect Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\M99EV2UJ\\S0731708511000306.html:text/html;ScienceDirect Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\KXCBNNNU\\Bungay et al. - 2011 - Unifying the mathematical modeling of in vivo and .pdf:application/pdf}
}

@article{nishida_diffusion_1983,
	title = {Diffusion coefficients of anticancer drugs and compounds having a similar structure at 30 °C},
	volume = {261},
	issn = {0303-402X, 1435-1536},
	url = {https://link.springer.com/article/10.1007/BF01411520},
	doi = {10.1007/BF01411520},
	abstract = {The measurement of the diffusion coefficients of anticancer drugs and compounds having a similar structure in aqueous solution at 30 °C are carried out and the effect of some groups affecting the diffusion coefficients is investigated. The measurements of viscosity are also carried out in order to obtain the viscosity coefficient.The radius of molecule from the diffusion coefficients is in agreement with the value from the viscosity measurements.Under the concentration range studied, it seem that these compounds have a same state, for example, monomer or dimer. However, from Van der Waals radius of the results obtained, these solutes are monomer state.In spite of a large size, the diffusion coefficient of Uridine-5′-monophosphoric acid indicates a high value because of the potential gradient occurs in diffusion. From the result, 5-fluoro-2′-deoxy-5′-monophosphoric acid diffuses quickly in human body in spite of the large molecular weight.},
	pages = {70--73},
	number = {1},
	journaltitle = {Colloid and Polymer Science},
	shortjournal = {Colloid \& Polymer Sci},
	author = {Nishida, K. and Ando, Y. and Kawamura, H.},
	urldate = {2017-04-12},
	date = {1983-01-01},
	langid = {english},
	file = {Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\TM3D6PFD\\BF01411520.html:text/html;Full Text PDF:C\:\\Users\\nazmula\\Zotero\\storage\\HNIG5QNV\\Nishida et al. - 1983 - Diffusion coefficients of anticancer drugs and com.pdf:application/pdf}
}

@article{liu_measurement_1997,
	title = {Measurement of Biomolecular Diffusion Coefficients in Blood Plasma Using Two-Dimensional 1H−1H Diffusion-Edited Total-Correlation {NMR} Spectroscopy},
	volume = {69},
	issn = {0003-2700},
	url = {http://dx.doi.org/10.1021/ac9612133},
	doi = {10.1021/ac9612133},
	abstract = {The use of two-dimensional diffusion-edited total-correlation {NMR} spectroscopy ({DETOCSY}) to measure diffusion coefficients of molecules in biofluids is demonstrated. The method takes advantage of the increased peak dispersion in a two-dimensional spectrum and allows the measurement of diffusion coefficients of individual molecules in complex biofluid samples in a condition close to their natural state. The {NMR} spectra can be edited on the basis of diffusion coefficient, and hence, approximate molecular size and this provides a qualitative means of simplifying the spectra for assignment purposes. The use of two-dimensional {DETOCSY} {NMR} spectra increases the probability that the individual cross-peaks arise from single components and hence allows single-exponential fitting of the magnetic field gradient dependence of cross-peak volumes. Interpretation of the derived diffusion coefficients improves the {NMR} resonance assignment process in complex biofluid mixtures by giving additional information on the molecular size. The {DETOCSY} approach also provides information on small molecule−macromolecule interactions such as the binding of drugs or endogenous species to serum proteins such as albumin.},
	pages = {1504--1509},
	number = {8},
	journaltitle = {Analytical Chemistry},
	shortjournal = {Anal. Chem.},
	author = {Liu, Maili and Nicholson, Jeremy K. and Parkinson, John A. and Lindon, John C.},
	urldate = {2017-04-11},
	date = {1997-04-01},
	file = {ACS Full Text Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\DJ4BZPM9\\ac9612133.html:text/html;ACS Full Text PDF w/ Links:C\:\\Users\\nazmula\\Zotero\\storage\\3J2BDCFE\\Liu et al. - 1997 - Measurement of Biomolecular Diffusion Coefficients.pdf:application/pdf}
}

@article{gredell_determination_2004,
	title = {Determination of diffusion and partition coefficients of propofol in rat brain tissue: implications for studies of drug action in vitro},
	volume = {93},
	issn = {0007-0912},
	url = {https://academic.oup.com/bja/article/93/6/810/266632/Determination-of-diffusion-and-partition},
	doi = {10.1093/bja/aeh272},
	shorttitle = {Determination of diffusion and partition coefficients of propofol in rat brain tissue},
	pages = {810--817},
	number = {6},
	journaltitle = {{BJA}: British Journal of Anaesthesia},
	shortjournal = {Br J Anaesth},
	author = {Gredell, J. A. and Turnquist, P. A. and {MacIver}, M. B. and Pearce, R. A.},
	urldate = {2017-04-11},
	date = {2004-12-01},
	file = {Snapshot:C\:\\Users\\nazmula\\Zotero\\storage\\PJR6757I\\Determination-of-diffusion-and-partition.html:text/html}
}

@article{reyes-garces_high_2014-1,
	title = {High throughput quantification of prohibited substances in plasma using thin film solid phase microextraction},
	volume = {1374},
	issn = {00219673},
	url = {http://linkinghub.elsevier.com/retrieve/pii/S0021967314018056},
	doi = {10.1016/j.chroma.2014.11.047},
	pages = {40--49},
	journaltitle = {Journal of Chromatography A},
	author = {Reyes-Garcés, Nathaly and Bojko, Barbara and Pawliszyn, Janusz},
	urldate = {2017-04-11},
	date = {2014-12},
	langid = {english},
	file = {1-s2.0-S0021967314018056-main.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\R4NB6WAB\\1-s2.0-S0021967314018056-main.pdf:application/pdf}
}

@article{peltenburg_sensitive_2015,
	title = {Sensitive determination of plasma protein binding of cationic drugs using mixed-mode solid-phase microextraction},
	volume = {115},
	issn = {07317085},
	url = {http://linkinghub.elsevier.com/retrieve/pii/S073170851530100X},
	doi = {10.1016/j.jpba.2015.08.002},
	pages = {534--542},
	journaltitle = {Journal of Pharmaceutical and Biomedical Analysis},
	author = {Peltenburg, Hester and Bosman, Ingrid J. and Hermens, Joop L.M.},
	urldate = {2017-04-11},
	date = {2015-11},
	langid = {english},
	file = {1-s2.0-S073170851530100X-main.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\N2BKNRBA\\1-s2.0-S073170851530100X-main.pdf:application/pdf}
}

@article{piekarski_way_2012,
	title = {On the Way to More Convenient Description of Drug–Plasma Protein Binding},
	url = {https://pdfs.semanticscholar.org/47eb/6a5b3f927758b5dbab63a5d20540989b501c.pdf},
	journaltitle = {{arXiv} preprint {arXiv}:1208.4217},
	author = {Piekarski, S. and Rewekant, M.},
	urldate = {2017-04-11},
	date = {2012},
	file = {1208.4217.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\3UA8TTCU\\1208.4217.pdf:application/pdf}
}

@article{talbert_determination_2002,
	title = {Determination of Drug−Plasma Protein Binding Kinetics and Equilibria by Chromatographic Profiling: Exemplification of the Method Using {\textless}span style="font-variant:small-caps;"{\textgreater}l{\textless}/span{\textgreater} -Tryptophan and Albumin},
	volume = {74},
	issn = {0003-2700, 1520-6882},
	url = {http://pubs.acs.org/doi/abs/10.1021/ac010643c},
	doi = {10.1021/ac010643c},
	shorttitle = {Determination of Drug−Plasma Protein Binding Kinetics and Equilibria by Chromatographic Profiling},
	pages = {446--452},
	number = {2},
	journaltitle = {Analytical Chemistry},
	author = {Talbert, Ann M. and Tranter, George E. and Holmes, Elaine and Francis, Peter L.},
	urldate = {2017-04-11},
	date = {2002-01},
	langid = {english},
	file = {ac010643c.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\WUGG66JZ\\ac010643c.pdf:application/pdf}
}

@article{timerbaev_interactions_2006,
	title = {Interactions of Antitumor Metallodrugs with Serum Proteins: Advances in Characterization Using Modern Analytical Methodology},
	volume = {106},
	issn = {0009-2665, 1520-6890},
	url = {http://pubs.acs.org/doi/abs/10.1021/cr040704h},
	doi = {10.1021/cr040704h},
	shorttitle = {Interactions of Antitumor Metallodrugs with Serum Proteins},
	pages = {2224--2248},
	number = {6},
	journaltitle = {Chemical Reviews},
	author = {Timerbaev, Andrei R. and Hartinger, Christian G. and Aleksenko, Svetlana S. and Keppler, Bernhard K.},
	urldate = {2017-04-11},
	date = {2006-06},
	langid = {english},
	file = {cr040704h.pdf:C\:\\Users\\nazmula\\Zotero\\storage\\MJAAXD2I\\cr040704h.pdf:application/pdf}
}

@article{musteata_determination_2006-1,
	title = {Determination of drug plasma protein binding by solid phase microextraction},
	volume = {95},
	issn = {00223549},
	url = {http://linkinghub.elsevier.com/retrieve/pii/S0022354916320639},
	doi = {10.1002/jps.20

license: MIT

license_type: permissive

branch_name: refs/heads/master