text:
GWAS) of major depressive disorder (MDD) in 1221 cases from the Sequenced Treatment Alternatives to Relieve Depression (STAR(*)D) study and 1636 screened controls. No genome-wide evidence for association was detected. We also carried out a meta-analysis of three European-ancestry MDD GWAS data sets: STAR(*)D, Genetics of Recurrent Early-onset Depression and the publicly available Genetic Association Information Network-MDD data set. These data sets, totaling 3957 cases and 3428 controls, were genotyped using four different platforms (Affymetrix 6.0, 5.0 and 500 K, and Perlegen). For each of 2.4 million HapMap II single-nucleotide polymorphisms (SNPs), using genotyped data where available and imputed data otherwise, single-SNP association tests were carried out in each sample with correction for ancestry-informative principal components. The strongest evidence for association in the meta-analysis was observed for intronic SNPs in ATP6V1B2 (P=6.78 x 10(-7)), SP4 (P=7.68 x 10(-7)) and GRM7 (P=1.11 x 10(-6)). Additional exploratory analyses were carried out for a narrower phenotype (recurrent MDD with onset before age 31, N=2191 cases), and separately for males and females. Several of the best findings were supported primarily by evidence from narrow cases or from either males or females. On the basis of previous biological evidence, we consider GRM7 a strong MDD candidate gene. Larger samples will be required to determine whether any common SNPs are significantly associated with MDD.Molecular Psychiatry advance online publication, 29 December 2009; doi:10.1038/mp.2009.125.},
affiliation = {Department of Psychiatry and Institute for Human Genetics, University of California, San Francisco, CA, USA.},
pages = {},
year = {2009},
month = {Dec},
language = {ENG},
date-added = {2010-01-17 21:42:04 +0100},
date-modified = {2010-01-17 21:42:04 +0100},
doi = {10.1038/mp.2009.125},
pii = {mp2009125},
pmid = {20038947},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3964},
rating = {0}
}

@article{Foxx:2008p6053,
author = {Richard M Foxx},
journal = {Child Adolesc Psychiatr Clin N Am},
title = {Applied behavior analysis treatment of autism: the state of the art},
abstract = {The treatment of individuals with autism is associated with fad, controversial, unsupported, disproven, and unvalidated treatments. Eclecticism is not the best approach for treating and educating children and adolescents who have autism. Applied behavior analysis (ABA) uses methods derived from scientifically established principles of behavior and incorporates all of the factors identified by the US National Research Council as characteristic of effective interventions in educational and treatment programs for children who have autism. ABA is a primary method of treating aberrant behavior in individuals who have autism. The only interventions that have been shown to produce comprehensive, lasting results in autism have been based on the principles of ABA.},
affiliation = {Psychology Program, Penn State University Harrisburg, 777 West Harrisburg Pike, Middletown, PA 17057, USA. rmf4@psu.edu},
number = {4},
pages = {821--34, ix},
volume = {17},
year = {2008},
month = {Oct},
language = {eng},
keywords = {Evidence-Based Medicine, Treatment Outcome, Child Behavior Disorders, Autistic Disorder, Social Behavior, Child, Combined Modality Therapy, Humans, Behavior Therapy, Adolescent},
date-added = {2010-02-19 17:01:17 +0100},
date-modified = {2010-02-19 17:01:17 +0100},
doi = {10.1016/j.chc.2008.06.007},
pii = {S1056-4993(08)00041-2},
pmid = {18775372},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6053},
rating = {0}
}

@article{Goldberg:2006p13887,
author = {L R Goldberg},
journal = {Journal of Research in Personality},
title = {Doing it all Bass-Ackwards: The development of hierarchical factor structures from the top down},
abstract = {A simple method is presented for examining the hierarchical structure of a set of variables, based on factor scores from rotated solutions involving one to many factors. The correlations among orthogonal factor scores from adjoining levels can be viewed as path coeYcients in a hierarchical structure. The method is easily implemented using any of a wide variety of standard computer pro- grams, and it has proved to be extremely useful in a number of diverse applications, some of which are here described.},
pages = {347--358},
volume = {40},
year = {2006},
date-added = {2010-07-29 18:09:30 +0200},
date-modified = {2010-07-29 18:31:12 +0200},
doi = {10.1016/j.jrp.2006.01.001},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Goldberg-2006-Journal%20of%20Research%20in%20Personality_Doing%20it%20all%20Bass-Ac.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13887},
rating = {0}
}

@article{Nagoshi:1982p12584,
author = {C T Nagoshi and R C Johnson and F M Ahern and G P Danko and J R Wilson and L S Yamamoto and J Samet-Driver and S G Vandenberg},
journal = {Behav Genet},
title = {Correlations of measures of personality and of cognitive abilities within and across generations},
number = {3},
pages = {327--42},
volume = {12},
year = {1982},
month = {May},
language = {eng},
keywords = {Adolescent, Male, Adult, Cognition, Genotype, Middle Aged, Humans, Female, Personality, Hawaii},
date-added = {2010-06-15 22:36:58 +0200},
date-modified = {2010-07-29 20:09:06 +0200},
pmid = {7126110},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Nagoshi-1982-Behav%20Genet_Correlations%20of%20meas.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12584},
rating = {3}
}

@article{Page:2001p5388,
author = {A C Page and G R Hooke and E M Rutherford},
journal = {Aust N Z J Psychiatry},
title = {Measuring mental health outcomes in a private psychiatric clinic: Health of the Nation Outcome Scales and Medical Outcomes Short Form SF-36},
abstract = {OBJECTIVE: This study reports on data collected from the routine use of the Health of the Nation Outcome Scales (HoNOS) and the Medical Outcomes Short Form (SF-36). Three main aims were addressed in using these measures: (i) to establish patient disability levels; (ii) to determine the level of treatment effectiveness; and (iii) to explore the ability of these instruments to predict length of stay and mood change. METHOD: The clinician-rate HoNOS and the patient-rated SF-36 were included in the assessment battery, at admission and discharge, of consecutive inpatients (n = 754) at one private psychiatric facility over a 2-year period. RESULTS: The sample, on admission, was comparable in illness severity to levels reported at other Australian private psychiatric facilities. Treatment was shown to be effective, and the degree of changes in HoNOS ratings compared favourably with other private psychiatric facilities. Certain factors underlying the structure of the HoNOS and the SF-36 only weakly predicted length of stay and changes in depression and anxiety levels. CONCLUSION: The HoNOS and the SF-36 provided valid and reliable data on patient function, with the HoNOS being most sensitive to treatment change. However, neither instrument proved useful in predicting length of stay or levels of depression and anxiety at discharge.},
affiliation = {Department of Psychology, The University of Western Australia, Crawley, Australia. andrew@psy.uwa.edu.au},
number = {3},
pages = {377--81},
volume = {35},
year = {2001},
month = {Jun},
language = {eng},
keywords = {Hospitals: Psychiatric, Adult, Mental Disorders, Humans, Personality Assessment, Outcome and Process Assessment (Health Care), Reproducibility of Results, Patient Admission, Male, Hospitals: Private, Western Australia, Psychiatric Status Rating Scales, Middle Aged, Psychometrics, Female},
date-added = {2010-02-11 10:35:38 +0100},
date-modified = {2010-07-29 19:51:56 +0200},
pii = {anp908},
pmid = {11437813},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5388},
rating = {0}
}

@article{Reilly:1997p12568,
author = {M Reilly and M Pepe},
journal = {Stat Med},
title = {The relationship between hot-deck multiple imputation and weighted likelihood},
abstract = {Hot-deck imputation is an intuitively simple and popular method of accommodating incomplete data. Users of the method will often use the usual multiple imputation variance estimator which is not appropriate in this case. However, no variance expression has yet been derived for this easily implemented method applied to missing covariates in regression models. The simple hot-deck method is in fact asymptotically equivalent to the mean-score method for the estimation of a regression model parameter, so that hot-deck can be understood in the context of likelihood methods. Both of these methods accommodate data where missingness may depend on the observed variables but not on the unobserved value of the incomplete covariate, that is, missing at random (MAR). The asymptotic properties of hot-deck are derived here for the case where the fully observed variables are categorical, though the incomplete covariate(s) may be continuous. Simulation studies indicate that the two methods compare well in small samples and for small numbers of imputations. Current users of hot-deck may now conduct their analysis using mean-score, which is a weighted likelihood method and can thus be implemented by a single pass through the data using any standard package which accommodates weighted regression models. Valid inference is now straightforward using the variance expression provided here. The equivalence of mean-score and hot-deck is illustrated using three clinical data sets where an important covariate is missing for a large number of study subjects.},
affiliation = {Department of Statistics, University College Dublin, Belfield, Ireland.},
number = {1-3},
pages = {5--19},
volume = {16},
year = {1997},
month = {Jan},
language = {eng},
keywords = {Pregnancy: Tubal, Computer Simulation, Models: Statistical, Graft vs Host Disease, Recurrence, Female, Pregnancy, Data Interpretation: Statistical, Least-Squares Analysis, Coronary Disease, Sample Size, Follow-Up Studies, Bone Marrow Transplantation, Clinical Trials as Topic, Bayes Theorem, Risk Factors, Humans, Angioplasty: Transluminal: Percutaneous Coronary, Likelihood Functions, Case-Control Studies},
date-added = {2010-06-15 22:19:46 +0200},
date-modified = {2010-06-15 22:19:46 +0200},
pii = {10.1002/(SICI)1097-0258(19970115)16:1<5::AID-SIM469>3.0.CO;2-8},
pmid = {9004380},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12568},
rating = {0}
}

@article{Ji:2008p7234,
author = {Shuiwang Ji and Jieping Ye},
journal = {IEEE transactions on neural networks / a publication of the IEEE Neural Networks Council},
title = {Generalized linear discriminant analysis: a unified framework and efficient model selection},
abstract = {High-dimensional data are common in many domains, and dimensionality reduction is the key to cope with the curse-of-dimensionality. Linear discriminant analysis (LDA) is a well-known method for supervised dimensionality reduction. When dealing with high-dimensional and low sample size data, classical LDA suffers from the singularity problem. Over the years, many algorithms have been developed to overcome this problem, and they have been applied successfully in various applications. However, there is a lack of a systematic study of the commonalities and differences of these algorithms, as well as their intrinsic relationships. In this paper, a unified framework for generalized LDA is proposed, which elucidates the properties of various algorithms and their relationships. Based on the proposed framework, we show that the matrix computations involved in LDA-based algorithms can be simplified so that the cross-validation procedure for model selection can be performed efficiently. We conduct extensive experiments using a collection of high-dimensional data sets, including text documents, face images, gene expression data, and gene expression pattern images, to evaluate the proposed theories and algorithms.},
affiliation = {Department of Computer Science and Engineering, and the Center for Evolutionary Functional Genomics of The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA. shuiwang.ji@asu.edu},
number = {10},
pages = {1768--82},
volume = {19},
year = {2008},
month = {Oct},
language = {eng},
keywords = {Models: Theoretical, Linear Models, Artificial Intelligence, Algorithms, Numerical Analysis: Computer-Assisted, Computer Simulation, Discriminant Analysis, Pattern Recognition: Automated},
date-added = {2010-03-08 19:33:35 +0100},
date-modified = {2010-03-08 19:33:35 +0100},
doi = {10.1109/TNN.2008.2002078},
pmid = {18842480},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7234},
rating = {0}
}

@article{Lubienski:2006,
author = {S T Lubienski},
journal = {Educationa Policy Analysis Archives},
title = {Examining Instruction, Achievement, and Equity with NAEP Mathematics Data},
number = {14},
volume = {14},
year = {2006},
date-added = {2010-01-10 11:33:09 +0100},
date-modified = {2010-01-10 11:33:25 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Lubienski-2006-Educationa%20Policy%20Analysis%20Archives_Examining%20Instructio.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1925},
rating = {0}
}

@article{Li:2008p3830,
author = {Hao Li and Sally Wetten and Li Li and Pamela L St Jean and Ruchi Upmanyu and Linda Surh and David Hosford and Michael R Barnes and James David Briley and Michael Borrie and Natalie Coletta and Richard Delisle and Daniella Dhalla and Margaret G Ehm and Howard H Feldman and Luis Fornazzari and Serge Gauthier and Neil Goodgame and Danilo Guzman and Sandra Hammond and Paul Hollingworth and Ging-Yuek Hsiung and Joan Johnson and Devon D Kelly and Ron Keren and Andrew Kertesz and Karen S King and Simon Lovestone and Inge Loy-English and Paul M Matthews and Michael J Owen and Mary Plumpton and William Pryse-Phillips and Rab K Prinjha and Jill C Richardson and Ann Saunders and Andrew J Slater and Peter H St George-Hyslop and Sandra W Stinnett and Jina E Swartz and Rachel L Taylor and John Wherrett and Julie Williams and David P Yarnall and Rachel A Gibson and Michael C Irizarry and Lefkos T Middleton and Allen D Roses},
journal = {Arch Neurol},
title = {Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease},
abstract = {OBJECTIVE: To identify single-nucleotide polymorphisms (SNPs) associated with risk and age at onset of Alzheimer disease (AD) in a genomewide association study of 469 438 SNPs. DESIGN: Case-control study with replication. SETTING: Memory referral clinics in Canada and the United Kingdom. PARTICIPANTS: The hypothesis-generating data set consisted of 753 individuals with AD by National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association criteria recruited from 9 memory referral clinics in Canada and 736 ethnically matched control subjects; control subjects were recruited from nonbiological relatives, friends, or spouses of the patients and did not exhibit cognitive impairment by history or cognitive testing. The follow-up data set consisted of 418 AD cases and 249 nondemented control cases from the United Kingdom Medical Research Council Genetic Resource for Late-Onset AD recruited from clinics at Cardiff University, Cardiff, Wales, and King's College London, London, England. MAIN OUTCOME MEASURES: Odds ratios and 95% confidence intervals for association of SNPs with AD by logistic regression adjusted for age, sex, education, study site, and French Canadian ancestry (for the Canadian data set). Hazard ratios and 95% confidence intervals from Cox proportional hazards regression for age at onset with similar covariate adjustments. RESULTS: Unadjusted, SNP RS4420638 within APOC1 was strongly associated with AD due entirely to linkage disequilibrium with APOE. In the multivariable adjusted analyses, 3 SNPs within the top 120 by P value in the logistic analysis and 1 in the Cox analysis of the Canadian data set provided additional evidence for association at P< .05 within the United Kingdom Medical Research Council data set: RS7019241 (GOLPH2), RS10868366 (GOLPH2), RS9886784 (chromosome 9), and RS10519262 (intergenic between ATP8B4 and SLC27A2). CONCLUSIONS: Our genomewide association analysis again identified the APOE linkage disequilibrium region as the strongest genetic risk factor for AD. This could be a consequence of the coevolution of more than 1 susceptibility allele, such as APOC1, in this region. We also provide new evidence for additional candidate genetic risk factors for AD that can be tested in further studies.},
affiliation = {GlaxoSmithKline, Research Triangle Park, North Carolina, USA.},
number = {1},
pages = {45--53},
volume = {65},
year = {2008},
month = {Jan},
language = {eng},
keywords = {Sex Factors, France, Education, Female, Proportional Hazards Models, Logistic Models, Polymorphism: Single Nucleotide, Canada, Age Factors, Humans, Odds Ratio, Genome: Human, Alzheimer Disease, Great Britain, Male, Confidence Intervals, Registries, Aged, Apolipoproteins E, Oligonucleotide Array Sequence Analysis, Genotype, Case-Control Studies},
date-added = {2010-01-16 21:02:05 +0100},
date-modified = {2010-07-29 19:17:13 +0200},
doi = {10.1001/archneurol.2007.3},
pii = {2007.3},
pmid = {17998437},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3830},
rating = {0}
}

@article{Nosarti:2005p7896,
author = {Chiara Nosarti and Matthew P Allin and Sophia Frangou and Larry Rifkin and Robin M Murray},
journal = {Biol Psychiatry},
title = {Hyperactivity in adolescents born very preterm is associated with decreased caudate volume},
abstract = {BACKGROUND: Several studies have associated preterm birth with impaired behavioral functioning and attention problems. In addition, preterm individuals have an increased risk of brain injury in the neonatal period. Such early lesions have the potential to disrupt subsequent neurodevelopment. This study explored behavioral functioning, particularly externalizing behavior, in a group of adolescents who were born very preterm and its relationship with volume of the caudate, a brain region particularly vulnerable to damage in the preterm neonate. METHODS: We studied 72 adolescents born before 33 weeks and 50 age- and gender-matched full-term control subjects. Behavioral assessment included the Rutter Behavioural Scale and a social adjustment scale. Bilateral caudate volumes were quantified by stereologic methods. RESULTS: Preterm adolescents scored significantly higher than control subjects on the Rutter hyperactivity score, and boys scored higher than girls. In preterm boys only, left caudate volume was negatively correlated with hyperactivity score (r = -.43, p = .018) and social adjustment score in childhood (r = -.40, p = .028). CONCLUSIONS: Our data suggest that boys born very preterm are more likely to experience nonclinical behavioral problems in adolescence compared with full-term control subjects. Our results indicate that behavioral problems in this group might be associated with reductions in volume of the left caudate nucleus.},
affiliation = {Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom. c.nosarti@iop.kcl.ac.uk},
number = {6},
pages = {661--6},
volume = {57},
year = {2005},
month = {Mar},
language = {eng},
keywords = {Infant: Very Low Birth Weight, Functional Laterality, Humans, Premature Birth, Hyperkinesis, Confidence Intervals, Female, Case-Control Studies, Developmental Disabilities, Retrospective Studies, Analysis of Variance, Infant: Newborn, Infant: Premature, Child Behavior Disorders, Adolescent, Social Adjustment, Cohort Studies, Magnetic Resonance Imaging, Neuropsychological Tests, Caudate Nucleus, Male},
date-added = {2010-03-20 19:20:24 +0100},
date-modified = {2010-07-29 20:19:01 +0200},
doi = {10.1016/j.biopsych.2004.12.003},
pii = {S0006-3223(04)01307-1},
pmid = {15780854},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Nosarti-2005-Biol%20Psychiatry_Hyperactivity%20in%20ado.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7896},
rating = {0}
}

@article{Cremeens:2007p8491,
author = {Joanne Cremeens and Christine Eiser and Mark Blades},
journal = {J Pediatr Psychol},
title = {Brief report: assessing the impact of rating scale type, types of items, and age on the measurement of school-age children's self-reported quality of life},
abstract = {OBJECTIVE: To examine the effect of age, scale, and item type on the reliability and reproducibility of children's quality-of-life (QOL) responses. METHODS: The TedQL (ability, social, and mood items) was administered to 266 healthy children (age range of 5-6 and 7-9 years) at two time points, comparing three rating scales (circles, faces, and thermometer). Children were given the same (n = 144) or different (n = 122) scales over time. RESULTS: Reliability for total QOL and ability items was highest for circles and for social items using the faces. Faces and thermometer scales showed highest reproducibility over time. Greater agreement over time across different scales was found between circles and faces (5-6 years) and thermometer and circles (7-9 years). CONCLUSIONS: For maximum internal reliability, circles are recommended for ability items and faces for social items. For maximum reproducibility over time, the thermometer is recommended for 5-6 years and faces for 7-9 years.},
affiliation = {Division of Behavioral Medicine, St. Jude Children's Research Hospital, 332 North Lauderdale, Mail Stop No. 740, Memphis, Tennessee 38105-2794, USA. joanne.cremeens@stjude.org},
number = {2},
pages = {132--8},
volume = {32},
year = {2007},
month = {Mar},
language = {eng},
keywords = {Age Factors, Male, Sickness Impact Profile, Reproducibility of Results, Child: Preschool, Humans, Child, Female, Reference Values, Quality of Life, Psychometrics},
date-added = {2010-03-21 18:01:02 +0100},
date-modified = {2010-07-29 19:35:17 +0200},
doi = {10.1093/jpepsy/jsj119},
pii = {jsj119},
pmid = {16625022},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Cremeens-2007-J%20Pediatr%20Psychol_Brief%20report%20assess.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8491},
read = {Yes},
rating = {0}
}

@article{Linden:2004p3628,
author = {W J van der Linden and B P Veldkamp and J E Carlson},
journal = {Applied Psychological Measurement},
title = {Optimizing Balanced Incomplete Block Designs for Educational Assessments},
abstract = {A popular design in large-scale educational assessments as well as any other type of survey is the balanced incomplete block design. The design is based on an item pool split into a set of blocks of items that are assigned to sets of ``assessment booklets.'' This article shows how the problem of calculating an optimal balanced incomplete block design can be formulated as a problem in combinatorial optimization. Several examples of structural and practical requirements for balanced incomplete block designs are shown to be linear constraints on the optimization problem. In addition, a variety of possible objective functions to optimize the design is discussed. The technique is demonstrated using the 1996 Grade 8 Mathematics National Assessment of Educational Progress (NAEP) as a case study.},
number = {5},
pages = {317--331},
volume = {28},
year = {2004},
date-added = {2010-01-16 19:15:28 +0100},
date-modified = {2010-01-16 19:16:47 +0100},
doi = {10.1177/0146621604264870},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Linden-2004-Applied%20Psychological%20Measurement_Optimizing%20Balanced.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3628},
rating = {0}
}

@article{Zhang:2010p12343,
author = {Kai Zhang and Joe W Gray and Bahram Parvin},
journal = {Bioinformatics},
title = {Sparse multitask regression for identifying common mechanism of response to therapeutic targets},
abstract = {MOTIVATION: Molecular association of phenotypic responses is an important step in hypothesis generation and for initiating design of new experiments. Current practices for associating gene expression data with multidimensional phenotypic data are typically (i) performed one-to-one, i.e. each gene is examined independently with a phenotypic index and (ii) tested with one stress condition at a time, i.e. different perturbations are analyzed separately. As a result, the complex coordination among the genes responsible for a phenotypic profile is potentially lost. More importantly, univariate analysis can potentially hide new insights into common mechanism of response. RESULTS: In this article, we propose a sparse, multitask regression model together with co-clustering analysis to explore the intrinsic grouping in associating the gene expression with phenotypic signatures. The global structure of association is captured by learning an intrinsic template that is shared among experimental conditions, with local perturbations introduced to integrate effects of therapeutic agents. We demonstrate the performance of our approach on both synthetic and experimental data. Synthetic data reveal that the multi-task regression has a superior reduction in the regression error when compared with traditional L(1)-and L(2)-regularized regression. On the other hand, experiments with cell cycle inhibitors over a panel of 14 breast cancer cell lines demonstrate the relevance of the computed molecular predictors with the cell cycle machinery, as well as the identification of hidden variables that are not captured by the baseline regression analysis. Accordingly, the system has identified CLCA2 as a hidden transcript and as a common mechanism of response for two therapeutic agents of CI-1040 and Iressa, which are currently in clinical use.},
affiliation = {Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.},
number = {12},
pages = {i97--105},
volume = {26},
year = {2010},
month = {Jun},
language = {eng},
date-added = {2010-06-12 10:21:43 +0200},
date-modified = {2010-06-12 10:21:44 +0200},
doi = {10.1093/bioinformatics/btq181},
pii = {btq181},
pmid = {20529943},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Zhang-2010-Bioinformatics_Sparse%20multitask%20reg.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12343},
rating = {0}
}

@article{Godderis:2009p12759,
author = {Rebecca Godderis and Carol E Adair and Nancy Brager},
journal = {Women and birth : journal of the Australian College of Midwives},
title = {Applying new techniques to an old ally: a qualitative validation study of the Edinburgh Postnatal Depression Scale},
abstract = {PURPOSE: To present the results of a study that used cognitive interviewing techniques to interview pregnant and postpartum women about their experience of completing the Edinburgh Postnatal Depression Scale. BACKGROUND: Most large-scale initiatives that screen women for depression during pregnancy and the first 3-6 months postpartum use the Edinburgh Postnatal Depression Scale. The scale is a 10-item instrument that is commonly self-administered and has been extensively validated using quantitative methods. However, the authors could find no published research that applied newer in-depth methods for assessing comprehension and interpretation to the scale. PARTICIPANTS AND METHODS: The design was an in-depth, qualitative instrument validation study. A total of nine pregnant and postpartum women who were referred for psychiatric care completed the Edinburgh Postnatal Depression Scale and then were interviewed about their experiences. Cognitive interviewing techniques were used to generate an in-depth examination of how women understood and interpreted the items, and to explore meaning, acceptability, and disclosure issues. RESULTS: Overall, participants felt that the instrument was straightforward, easy to read, and relatively simple to answer. It is important to note that eight of the nine participants had completed some post-secondary education and, thus, participant's average literacy level was relatively high. Women identified minor concerns or expressed interpretive differences on six of the ten Edinburgh Postnatal Depression Scale items. These six items are examined in detail. CONCLUSION: The results suggest that it may be useful for the Edinburgh Postnatal Depression Scale to be administered in the context of a discussion about a woman's mental health concerns, which could involve asking her for more details about her responses to particular items that have been identified in this study as potentially problematic. This will help ensure that practitioners are accurately interpreting a woman's answers to the items on the scale.},
affiliation = {Department of Sociology, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada. rebecca.godderis@ucalgary.ca},
number = {1},
pages = {17--23},
volume = {22},
year = {2009},
month = {Mar},
language = {eng},
keywords = {Young Adult, Female, Patient Acceptance of Health Care, Adult, Depression: Postpartum, Questionnaires, Alberta, Reproducibility of Results, Life Change Events, Psychometrics, Social Environment, Risk Assessment, Humans, Mental Health, Postpartum Period},
date-added = {2010-06-15 22:52:01 +0200},
date-modified = {2010-06-15 22:52:06 +0200},
doi = {10.1016/j.wombi.2008.10.002},
pii = {S1871-5192(08)00102-9},
pmid = {19081313},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Godderis-2009-Women%20and%20birth%20journal%20of%20the%20Australian%20College%20of%20Midwives_Applying%20new%20techniq.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12759},
rating = {3}
}

@article{Macht:2008p1296,
author = {Michael Macht},
journal = {Appetite},
title = {How emotions affect eating: a five-way model},
abstract = {Despite the importance of affective processes in eating behaviour, it remains difficult to predict how emotions affect eating. Emphasizing individual differences, previous research did not pay full attention to the twofold variability of emotion-induced changes of eating (variability across both individuals and emotions). By contrast, the present paper takes into account both individual characteristics and emotion features, and specifies five classes of emotion-induced changes of eating: (1) emotional control of food choice, (2) emotional suppression of food intake, (3) impairment of cognitive eating controls, (4) eating to regulate emotions, and (5) emotion-congruent modulation of eating. These classes are distinguished by antecedent conditions, eating responses and mediating mechanisms. They point to basic functional principles underlying the relations between emotions and biologically based motives: interference, concomitance and regulation. Thus, emotion-induced changes of eating can be a result of interference of eating by emotions, a by-product of emotions, and a consequence of regulatory processes (i.e., emotions may regulate eating, and eating may regulate emotions).},
affiliation = {Department of Psychology, University of W{\"u}rzburg, Marcusstr. 9-11, 97070 W{\"u}rzburg, Germany. macht@psychologie.uni-wuerzburg.de},
number = {1},
pages = {1--11},
volume = {50},
year = {2008},
month = {Jan},
language = {eng},
keywords = {Food Preferences, Models: Biological, Humans, Eating, Emotions, Appetite Regulation, Food},
date-added = {2010-01-07 11:34:34 +0100},
date-modified = {2010-01-07 11:34:34 +0100},
doi = {10.1016/j.appet.2007.07.002},
pii = {S0195-6663(07)00323-6},
pmid = {17707947},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Macht-2008-Appetite_How%20emotions%20affect.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1296},
rating = {0}
}

@article{Postlethwaite:1993,
author = {T Neville Postlethwaite},
journal = {Perspectives : revue trimestrielle d'{\'e}ducation compar{\'e}e},
title = {TORSTEN HUS{\'E}N},
number = {3-4},
pages = {697--707},
volume = {XXIII},
year = {1993},
date-added = {2010-01-10 11:33:19 +0100},
date-modified = {2010-01-10 11:33:25 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Postlethwaite-1993-Perspectives%20revue%20trimestrielle%20d'%C3%A9ducation%20compar%C3%A9e_TORSTEN%20HUS%C3%89N.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2206},
rating = {0}
}

@article{Bailey:2010p3693,
author = {R A Bailey and P J Cameron},
title = {A family of balanced incomplete-block designs with repeated blocks on which general linear groups act},
abstract = {We give two constructions of a balanced incomplete-block design discovered by van Lint: the design has parameters (13,39,15,5,5), and has repeated blocks and an automorphism group of order 240. One of these methods can be generalised to produce a large class of designs with the properties of the title.},
date-added = {2010-01-16 20:32:48 +0100},
date-modified = {2010-01-16 20:33:17 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Bailey--_A%20family%20of%20balanced.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3693},
rating = {0}
}

@article{Orro:2008p867,
author = {Alessandro Orro and Guia Guffanti and Erika Salvi and Fabio Macciardi and Luciano Milanesi},
journal = {BMC Bioinformatics},
title = {SNPLims: a data management system for genome wide association studies},
abstract = {BACKGROUND: Recent progresses in genotyping technologies allow the generation high-density genetic maps using hundreds of thousands of genetic markers for each DNA sample. The availability of this large amount of genotypic data facilitates the whole genome search for genetic basis of diseases. We need a suitable information management system to efficiently manage the data flow produced by whole genome genotyping and to make it available for further analyses. RESULTS: We have developed an information system mainly devoted to the storage and management of SNP genotype data produced by the Illumina platform from the raw outputs of genotyping into a relational database. The relational database can be accessed in order to import any existing data and export user-defined formats compatible with many different genetic analysis programs. After calculating family-based or case-control association study data, the results can be imported in SNPLims. One of the main features is to allow the user to rapidly identify and annotate statistically relevant polymorphisms from the large volume of data analyzed. Results can be easily visualized either graphically or creating ASCII comma separated format output files, which can be used as input to further analyses. CONCLUSIONS: The proposed infrastructure allows to manage a relatively large amount of genotypes for each sample and an arbitrary number of samples and phenotypes. Moreover, it enables the users to control the quality of the data and to perform the most common screening analyses and identify genes that become "candidate" for the disease under consideration.},
affiliation = {Consorzio Interuniversitario Lombardo per l'Elaborazione Automatica, Via Sanzio Raffaello 4, 20090 Segrate (MI), Italy. alessandro.orro@itb.cnr.it},
pages = {S13},
volume = {9 Suppl 2},
year = {2008},
month = {Jan},
language = {eng},
keywords = {Information Storage and Retrieval, Chromosome Mapping, DNA Mutational Analysis, Database Management Systems, Linkage Disequilibrium, Databases: Genetic, Polymorphism: Single Nucleotide, User-Computer Interface},
date-added = {2010-01-03 18:08:24 +0100},
date-modified = {2010-01-03 18:08:24 +0100},
doi = {10.1186/1471-2105-9-S2-S13},
pii = {1471-2105-9-S2-S13},
pmid = {18387201},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Orro-2008-BMC%20Bioinformatics_SNPLims%20a%20data%20mana.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p867},
rating = {0}
}

@article{Potkin:2009p9580,
author = {Steven G Potkin and Guia Guffanti and Anita Lakatos and Jessica A Turner and Frithjof Kruggel and James H Fallon and Andrew J Saykin and Alessandro Orro and Sara Lupoli and Erika Salvi and Michael Weiner and Fabio Macciardi and Alzheimer's Disease Neuroimaging Initiative},
journal = {PLoS ONE},
title = {Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease},
abstract = {BACKGROUND: With the exception of APOE epsilon4 allele, the common genetic risk factors for sporadic Alzheimer's Disease (AD) are unknown. METHODS AND FINDINGS: We completed a genome-wide association study on 381 participants in the ADNI (Alzheimer's Disease Neuroimaging Initiative) study. Samples were genotyped using the Illumina Human610-Quad BeadChip. 516,645 unique Single Nucleotide Polymorphisms (SNPs) were included in the analysis following quality control measures. The genotype data and raw genetic data are freely available for download (LONI, http://www.loni.ucla.edu/ADNI/Data/). Two analyses were completed: a standard case-control analysis, and a novel approach using hippocampal atrophy measured on MRI as an objectively defined, quantitative phenotype. A General Linear Model was applied to identify SNPs for which there was an interaction between the genotype and diagnosis on the quantitative trait. The case-control analysis identified APOE and a new risk gene, TOMM40 (translocase of outer mitochondrial membrane 40), at a genome-wide significance level of < or =10(-6) (10(-11) for a haplotype). TOMM40 risk alleles were approximately twice as frequent in AD subjects as controls. The quantitative trait analysis identified 21 genes or chromosomal areas with at least one SNP with a p-value < or =10(-6), which can be considered potential "new" candidate loci to explore in the etiology of sporadic AD. These candidates included EFNA5, CAND1, MAGI2, ARSB, and PRUNE2, genes involved in the regulation of protein degradation, apoptosis, neuronal loss and neurodevelopment. Thus, we identified common genetic variants associated with the increased risk of developing AD in the ADNI cohort, and present publicly available genome-wide data. Supportive evidence based on case-control studies and biological plausibility by gene annotation is provided. Currently no available sample with both imaging and genetic data is available for replication. CONCLUSIONS: Using hippocampal atrophy as a quantitative phenotype in a genome-wide scan, we have identified candidate risk genes for sporadic Alzheimer's disease that merit further investigation.},
affiliation = {Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA. sgpotkin@uci.edu},
number = {8},
pages = {e6501},
volume = {4},
year = {2009},
month = {Jan},
language = {eng},
keywords = {Quantitative Trait Loci, Genome-Wide Association Study, Hippocampus, Case-Control Studies, Magnetic Resonance Imaging, Genetic Predisposition to Disease, Male, Humans, Polymorphism: Single Nucleotide, Female, Adult, Alzheimer Disease},
date-added = {2010-03-24 22:26:32 +0100},
date-modified = {2010-03-24 22:26:32 +0100},
doi = {10.1371/journal.pone.0006501},
pmid = {19668339},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Potkin-2009-PLoS%20ONE_Hippocampal%20atrophy.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p9580},
rating = {0}
}

@article{Onay:2006p2584,
author = {Ven{\"u}s Ummiye Onay and Laurent Briollais and Julia A Knight and Ellen Shi and Yuanyuan Wang and Sean Wells and Hong Li and Isaac Rajendram and Irene L Andrulis and Hilmi Ozcelik},
journal = {BMC Cancer},
title = {SNP-SNP interactions in breast cancer susceptibility},
abstract = {BACKGROUND: Breast cancer predisposition genes identified to date (e.g., BRCA1 and BRCA2) are responsible for less than 5% of all breast cancer cases. Many studies have shown that the cancer risks associated with individual commonly occurring single nucleotide polymorphisms (SNPs) are incremental. However, polygenic models suggest that multiple commonly occurring low to modestly penetrant SNPs of cancer related genes might have a greater effect on a disease when considered in combination. METHODS: In an attempt to identify the breast cancer risk conferred by SNP interactions, we have studied 19 SNPs from genes involved in major cancer related pathways. All SNPs were genotyped by TaqMan 5'nuclease assay. The association between the case-control status and each individual SNP, measured by the odds ratio and its corresponding 95% confidence interval, was estimated using unconditional logistic regression models. At the second stage, two-way interactions were investigated using multivariate logistic models. The robustness of the interactions, which were observed among SNPs with stronger functional evidence, was assessed using a bootstrap approach, and correction for multiple testing based on the false discovery rate (FDR) principle. RESULTS: None of these SNPs contributed to breast cancer risk individually. However, we have demonstrated evidence for gene-gene (SNP-SNP) interaction among these SNPs, which were associated with increased breast cancer risk. Our study suggests cross talk between the SNPs of the DNA repair and immune system (XPD-[Lys751Gln] and IL10-[G(-1082)A]), cell cycle and estrogen metabolism (CCND1-[Pro241Pro] and COMT-[Met108/158Val]), cell cycle and DNA repair (BARD1-[Pro24Ser] and XPD-[Lys751Gln]), and within carcinogen metabolism (GSTP1-[Ile105Val] and COMT-[Met108/158Val]) pathways. CONCLUSION: The importance of these pathways and their communication in breast cancer predisposition has been emphasized previously, but their biological interactions through SNPs have not been described. The strategy used here has the potential to identify complex biological links among breast cancer genes and processes. This will provide novel biological information, which will ultimately improve breast cancer risk management.},
affiliation = {Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. onay@mshri.on.ca},
pages = {114},
volume = {6},
year = {2006},
month = {Jan},
language = {eng},
keywords = {Breast Neoplasms, Genes: Dominant, Case-Control Studies, Risk Factors, Genotype, Genes: Recessive, Polymorphism: Single Nucleotide, Genetic Predisposition to Disease, Breast Neoplasms: Male, Aged, Logistic Models, Adult, Male, Middle Aged, Female, Humans},
date-added = {2010-01-12 22:28:40 +0100},
date-modified = {2010-01-12 22:28:40 +0100},
doi = {10.1186/1471-2407-6-114},
pii = {1471-2407-6-114},
pmid = {16672066},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2584},
rating = {0}
}

@article{Deary:2009p9085,
author = {Ian J Deary and W Johnson and L M Houlihan},
journal = {Hum Genet},
title = {Genetic foundations of human intelligence},
abstract = {Individual differences in intelligence (cognitive abilities) are a prominent aspect of human psychology, and play a substantial role in influencing important life outcomes. Their phenotypic structure-as described by the science of psychometrics-is well understood and well replicated. Approximately half of the variance in a broad range of cognitive abilities is accounted by a general cognitive factor (g), small proportions of cognitive variance are caused by separable broad domains of mental function, and the substantial remainder is caused by variance that is unique to highly specific cognitive skills. The heritability of g is substantial. It increases from a low value in early childhood of about 30%, to well over 50% in adulthood, which continues into old age. Despite this, there is still almost no replicated evidence concerning the individual genes, which have variants that contribute to intelligence differences. Here, we describe the human intelligence phenotype, summarise the evidence for its heritability, provide an overview of and comment on molecular genetic studies, and comment on future progress in the field.},
affiliation = {Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, Scotland, UK. i.deary@ed.ac.uk},
number = {1},
pages = {215--32},
volume = {126},
year = {2009},
month = {Jul},
language = {eng},
keywords = {Twins: Monozygotic, Intelligence, Twins: Dizygotic, Genome-Wide Association Study, Adolescent, Cognition, Polymorphism: Single Nucleotide, Child, Child Development, Psychometrics, Aging, Twin Studies as Topic, Humans, Linkage (Genetics)},
date-added = {2010-03-22 13:22:41 +0100},
date-modified = {2010-07-29 19:28:44 +0200},
doi = {10.1007/s00439-009-0655-4},
pmid = {19294424},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Deary-2009-Hum%20Genet_Genetic%20foundations.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p9085},
rating = {0}
}

@article{Allik:2004p11622,
author = {J Allik and R R Mccrae},
title = {Toward a geography of personality traits. Patterns of profiles across 36 cultures},
abstract = {It has long been believed that personality traits vary by geographical location, but few studies have examined the worldwide distribution of personality profiles. Using the five-factor model of personality---a compre- hensive and apparently universal trait structure---we conducted secondary analyses of data from 36 cultures. Distance from the equator and mean temperature were not meaningfully related to personality factors. How- ever, cluster analysis showed that geographically proximate cultures often have similar profiles, and multidi- mensional scaling showed a clear contrast of European and American cultures with Asian and African cul- tures. The former were higher in extraversion and openness to experience and lower in agreeableness. A second dimension reflected differences in psychological adjustment. Observed differences between cultures may be the result of differences in gene pools or in features of culture; acculturation studies and the analyses of other natural experiments are needed to understand the origins of geographical differences in personality traits.},
year = {2004},
date-added = {2010-05-11 22:17:24 +0200},
date-modified = {2010-05-11 22:18:27 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Allik-2004-_Toward%20a%20geography%20o.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11622},
rating = {5}
}

@article{Hilt:2007p8955,
author = {Lori M Hilt and Lisa C Sander and Susan Nolen-Hoeksema and Arthur A Simen},
journal = {Neurosci Lett},
title = {The BDNF Val66Met polymorphism predicts rumination and depression differently in young adolescent girls and their mothers},
abstract = {A single nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene Val66Met has been associated with depression. However, the relationship between this SNP and depression has been mixed, especially when comparing studies of child and adult depression. We examined whether Val66Met would predict depression differentially in mothers versus their daughters. We also examined whether rumination, the tendency to brood and repetitively think about negative information, might serve as a mediator in the path between genotype and depressive symptoms. Participants included 200 individuals (100 mother-daughter pairs) from a high-risk population. The BDNF Val66Met polymorphism was examined in DNA samples from the mothers and daughters, and measures of depressive symptoms and rumination were also obtained. Among the young adolescent girls (ages 10-14), the Val/Val genotype was associated with more depressive symptoms and higher rumination scores compared to the Val/Met genotype. Furthermore, rumination mediated the relationship between genotype and depressive symptoms. However, in the mothers with adult-onset depression the Val/Met genotype was associated with more depressive symptoms, and rumination again mediated the relationship between genotype and depression. Rumination may be an endophenotype in the pathway from the BDNF Val66Met polymorphism to depression. Future work should further explore this mechanism and pursue explanations for its effects at different times in development.},
affiliation = {Department of Psychology, Yale University, New Haven, CT 06520-8250, United States. lori.hilt@yale.edu},
number = {1},
pages = {12--6},
volume = {429},
year = {2007},
month = {Dec},
language = {eng},
keywords = {Depression, Gene Frequency, Family Health, Mother-Child Relations, Adult, Brain-Derived Neurotrophic Factor, Feeding and Eating Disorders of Childhood, Adolescent, Polymorphism: Genetic, Methionine, Middle Aged, DNA Mutational Analysis, Valine, Female, Genetic Predisposition to Disease, Humans},
date-added = {2010-03-22 13:09:12 +0100},
date-modified = {2010-07-29 19:41:43 +0200},
doi = {10.1016/j.neulet.2007.09.053},
pii = {S0304-3940(07)01047-6},
pmid = {17959306},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Hilt-2007-Neurosci%20Lett_The%20BDNF%20Val66Met%20po.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8955},
rating = {0}
}

@article{Zhou:2006p3648,
author = {J Zhou and M J Gierl and X Tan},
title = {Evaluating the Performance of SIBTEST and MULTISIB Using Different Matching Criteria},
year = {2006},
date-added = {2010-01-16 19:56:35 +0100},
date-modified = {2010-01-16 19:57:01 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Zhou-2006-_Evaluating%20the%20Perfo.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3648},
rating = {0}
}

@article{Hwang:2002p2725,
author = {H Hwang and Y Takane},
journal = {Psychometrika},
title = {Generalized constrained multiple correspondance analysis},
number = {2},
pages = {211--224},
volume = {67},
year = {2002},
date-added = {2010-01-13 14:15:11 +0100},
date-modified = {2010-01-13 14:15:53 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Hwang-2002-Psychometrika_Generalized%20constrai.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2725},
rating = {0}
}

@article{Inkster:2010p8815,
author = {Becky Inkster and Thomas E Nichols and Philipp G Saemann and Dorothee P Auer and Florian Holsboer and Pierandrea Muglia and Paul M Matthews},
journal = {Neuroimage},
title = {Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression},
abstract = {Several lines of evidence implicate glycogen synthase kinase 3 beta (GSK3beta) in mood disorders. We recently reported associations between GSK3beta polymorphisms and brain structural changes in patients with recurrent major depressive disorder (MDD). Here we provide supporting observations by showing that polymorphisms in additional genes encoding proteins directly related to GSK3beta biological functions are associated with similar regional grey matter (GM) volume changes in MDD patients. We tested specifically for associations with genetic variation in canonical Wnt signaling pathway genes and in genes that encode substrate proteins of GSK3beta. We applied a general linear model with non-stationary cluster-based inference to examine associations between polymorphisms and regional voxel-based morphometry GM volume differences in recurrent MDD patients (n=134) and in age-, gender-, and ethnicity-matched healthy controls (n=144) to test for genotype-by-MDD interactions. We observed associations for polymorphisms in 8/13 canonical Wnt pathway genes and 5/10 GSK3beta substrate genes, predominantly in the temporolateral and medial prefrontal cortices. Similar associations were not found for 100 unrelated polymorphisms tested. This work suggests that identifying SNPs related to genes that encode functionally-interacting proteins that modulate common anatomical regions offers a useful approach to increasing confidence in outcomes from imaging genetics association studies. This is of particular interest when replication datasets are not available. Our observations lend support to the hypothesis that polymorphisms in GSK3beta play a role in MDD susceptibility or expression, in part, by acting via the canonical Wnt signaling pathway and related substrates.},
affiliation = {GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, London, United Kingdom.},
pages = {},
year = {2010},
month = {Feb},
language = {ENG},
date-added = {2010-03-22 12:31:44 +0100},
date-modified = {2010-03-22 12:31:45 +0100},
doi = {10.1016/j.neuroimage.2010.02.065},
pii = {S1053-8119(10)00252-1},
pmid = {20219685},
URL = {http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WNP-4YGHGS4-1&_user=2432700&_coverDate=02%252F26%252F2010&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000057263&_version=1&_urlVersion=0&_userid=2432700&md5=10de92a59697e086edce9bdf415f6a75},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Inkster-2010-Neuroimage_Pathway-based%20approa-1.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8815},
rating = {0}
}

@article{Odent:2010p7676,
author = {Michel Odent},
journal = {Med Hypotheses},
title = {Autism and anorexia nervosa: Two facets of the same disease?},
abstract = {We compiled data included in the Primal Health Research Database (www.primalhealthresearch.com) to test the hypothesis that when two pathological conditions or personality traits share the same critical period for gene-environment interaction, we should expect further similarities, particularly from clinical and pathophysiological perspectives. The keywords 'autism' and 'anorexia nervosa' (but not bulimia nervosa) lead to studies suggesting that for both conditions the perinatal period is critical. We take this example to look at other possible links between these pathological entities. From a clinical perspective, several teams have independently emphasized the importance of autistic traits in anorexia nervosa. Deficits in the processing of oxytocin have been demonstrated in both cases. Autistic groups have significantly lower blood oxytocin levels than normal groups, and oxytocin levels increase with age in the normal group only. In autistic groups there is a high ratio of intermediates of oxytocin synthesis (OX-T) to the nonapeptide oxytocin (OT). On the other hand, it has been reported that the level of oxytocin in the cerebrospinal fluid of anorexic women is significantly lower than the level of oxytocin in bulimic and control subjects. Scanning data reveal similar asymmetric functions with left hemisphere preponderance in autistic spectrum disorders and anorexia. A comparative study of the mirror neurons systems is another promising avenue for research. Such an accumulation of similarities from a great diversity of perspectives suggests that anorexia nervosa might be considered a female variant of the autistic spectrum. A plausible interpretation is that prenatal exposure to male hormones might protect against the expression of this disease: girls who have a twin brother are at low risk for anorexia nervosa, compared with girls who have a twin sister, and with controls; furthermore genetic linkage analyses do not detect change on the X chromosome. From an overview of the database, the perinatal period appears to be critical for all disorders related to the capacity to love (including love of oneself), to the potential for aggression (including self-destructive behaviours), or to sociability. Is the perinatal period critical for the organisation of the oxytocin system? This is an important question at a time when we learn that the widely used synthetic oxytocin can probably diffuse across the placenta. On the other hand, where the genesis of metabolic types is concerned, it is prenatal life that appears to be critical.},
affiliation = {Primal Health Research Centre, 72 Savernake Road, London NW3 2JR, UK.},
pages = {},
year = {2010},
month = {Feb},
language = {ENG},
date-added = {2010-03-15 23:48:20 +0100},
date-modified = {2010-03-15 23:48:20 +0100},
doi = {10.1016/j.mehy.2010.01.039},
pii = {S0306-9877(10)00055-1},
pmid = {20176449},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Odent-2010-Med%20Hypotheses_Autism%20and%20anorexia.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7676},
rating = {0}
}

@article{Ruczinski:2009p2919,
author = {I Ruczinski and Q Li and B Carvalho and M D Fallin and R A Irizarry and T A Louis},
journal = {Johns Hopkins University, Dept. of Biostatistics Working Papers},
title = {Association tests that accomodate genotyping errors},
abstract = {High-throughput SNP arrays provide estimates of genotypes for up to one million loci, often used in genome-wide association studies. While these estimates are typically very accurate, genotyping errors do occur, which can influence in particular the most extreme test statistics and p-values. Estimates for the genotype uncertainties are also available, although typically ignored. In this manuscript, we develop a framework to incorporate these genotype uncertainties in case-control studies for any genetic model. We verify that using the assumption of a ``local alternative'' in the score test is very reasonable for effect sizes typically seen in SNP association studies, and show that the power of the score test is simply a function of the correlation of the genotype probabilities with the true genotypes. We demonstrate that the power to detect a true association can be substantially increased for difficult to call genotypes, resulting in improved inference in asso- ciation studies.},
number = {181},
year = {2009},
date-added = {2010-01-13 21:53:40 +0100},
date-modified = {2010-01-13 21:54:53 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Ruczinski-2009-Johns%20Hopkins%20University%20Dept.%20of%20Biostatistics%20Working%20Papers_Association%20tests%20th.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2919},
rating = {0}
}

@article{Ranucci:2010p8985,
author = {Marco Ranucci and Serenella Castelvecchio and Lorenzo Menicanti and Alessandro Frigiola and Gabriele Pelissero},
journal = {Eur J Cardiothorac Surg},
title = {Accuracy, calibration and clinical performance of the EuroSCORE: can we reduce the number of variables?},
abstract = {BACKGROUND: The European system for cardiac operative risk evaluation (EuroSCORE) is currently used in many institutions and is considered a reference tool in many countries. We hypothesised that too many variables were included in the EuroSCORE using limited patient series. We tested different models using a limited number of variables. METHODS: A total of 11150 adult patients undergoing cardiac operations at our institution (2001-2007) were retrospectively analysed. The 17 risk factors composing the EuroSCORE were separately analysed and ranked for accuracy of prediction of hospital mortality. Seventeen models were created by progressively including one factor at a time. The models were compared for accuracy with a receiver operating characteristics (ROC) analysis and area under the curve (AUC) evaluation. Calibration was tested with Hosmer-Lemeshow statistics. Clinical performance was assessed by comparing the predicted with the observed mortality rates. RESULTS: The best accuracy (AUC 0.76) was obtained using a model including only age, left ventricular ejection fraction, serum creatinine, emergency operation and non-isolated coronary operation. The EuroSCORE AUC (0.75) was not significantly different. Calibration and clinical performance were better in the five-factor model than in the EuroSCORE. Only in high-risk patients were 12 factors needed to achieve a good performance. CONCLUSIONS: Including many factors in multivariable logistic models increases the risk for overfitting, multicollinearity and human error. A five-factor model offers the same level of accuracy but demonstrated better calibration and clinical performance. Models with a limited number of factors may work better than complex models when applied to a limited number of patients.},
affiliation = {Department of Cardiothoracic-Vascular Anesthesia and Intensive Care, IRCCS Policlinico S. Donato, Milan, Italy. cardioanestesia@virgilio.it},
number = {3},
pages = {724--9},
volume = {37},
year = {2010},
month = {Mar},
language = {eng},
date-added = {2010-03-22 13:11:05 +0100},
date-modified = {2010-03-22 13:11:05 +0100},
doi = {10.1016/j.ejcts.2009.08.033},
pii = {S1010-7940(09)00902-6},
pmid = {19819158},
URL = {http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T35-4XDKCC1-3&_user=2432700&_coverDate=03%252F31%252F2010&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000057263&_version=1&_urlVersion=0&_userid=2432700&md5=b00365b61bc49ea6645874f1b9dc807e},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Ranucci-2010-Eur%20J%20Cardiothorac%20Surg_Accuracy%20calibratio.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8985},
rating = {0}
}

@article{Baker:2005p3293,
author = {Stuart G Baker},
journal = {Statistical Applications in Genetics and Molecular Biology},
title = {A simple loglinear model for haplotype effects in a case-control study involving two unphased genotypes},
abstract = {Because haplotypes may parsimoniously summarize the effect of genes on disease, there is great interest in using haplotypes in case-control studies of unphased genotype data. Previous methods for investigating haplotypes effects in case-control studies have not allowed for both of the following two scenarios that could have a large impact on results (i) departures from Hardy-Weinberg equilibrium in controls as well as cases, and (ii) an interactive effect of haplotypes and environmental covariates on the probability of disease. A new method is proposed that generalizes the model of Epstein and Satten to incorporate both (i) and (ii). Computations are relatively simple involving a single loglinear design matrix for parameters modeling the distribution of haplotype frequencies in controls, parameters modeling the effect of haplotypes and covariate-haplotype interactions on disease, and nuisance parameters required for correct inference. Based on simulations with realistic sample sizes, the method is recommended with data from two genotypes, a recessive or dominant model linking haplotypes to disease, and estimates of haplotype effects among haplotypes with a frequency greater than 10%. The methodology is most useful with candidate genotype pairs or for searching through pairs of genotypes when scenarios (i) and (ii) are likely. An example without a covariate illustrates the importance of modeling a departure from Hardy-Weinberg equilibrium in controls.},
affiliation = {National Cancer Institute, USA. sb16i@nih.gov},
pages = {Article14},
volume = {4},
year = {2005},
month = {Jan},
language = {eng},
date-added = {2010-01-14 21:23:40 +0100},
date-modified = {2010-01-14 21:23:40 +0100},
doi = {10.2202/1544-6115.1113},
pmid = {16646831},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3293},
rating = {0}
}

@article{Vonesh:1992p2355,
author = {E F Vonesh and R L Carter},
journal = {Biometrics},
title = {Mixed-effects nonlinear regression for unbalanced repeated measures},
abstract = {Repeated measures data, such as clinical pharmacokinetic data, growth data, and dose-response data, are often inherently nonlinear with respect to a given response function and are frequently incomplete and/or unbalanced. Nonlinear random-effects models together with a variety of estimation procedures have been proposed for the analysis of such data. This paper is concerned with a straightforward procedure for estimating and comparing the parameters of a generalized mixed-effects nonlinear regression model. The asymptotic properties of the proposed estimators are given and large-sample tests of hypothesis provided. The results are applied to in vitro data on the water transport kinetics of hemodialyzers used in the treatment of patients with chronic renal failure.},
affiliation = {Applied Statistics Center, Baxter Healthcare Corp., Round Lake, Illinois 60073.},
number = {1},
pages = {1--17},
volume = {48},
year = {1992},
month = {Mar},
language = {eng},
keywords = {Water, Regression Analysis, Kidney: Artificial, Biometry, Kinetics, Humans, Biological Transport: Active, Models: Statistical},
date-added = {2010-01-10 13:38:40 +0100},
date-modified = {2010-01-10 13:38:40 +0100},
pmid = {1581479},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2355},
rating = {0}
}

@article{Toronen:2004p426,
author = {Petri Toronen},
journal = {BMC Bioinformatics},
title = {Selection of informative clusters from hierarchical cluster tree with gene classes},
abstract = {BACKGROUND: A common clustering method in the analysis of gene expression data has been hierarchical clustering. Usually the analysis involves selection of clusters by cutting the tree at a suitable level and/or analysis of a sorted gene list that is obtained with the tree. Cutting of the hierarchical tree requires the selection of a suitable level and it results in the loss of information on the other level. Sorted gene lists depend on the sorting method of the joined clusters. Author proposes that the clusters should be selected using the gene classifications. RESULTS: This article presents a simple method for searching for clusters with the strongest enrichment of gene classes from a cluster tree. The clusters found are presented in the estimated order of importance. The method is demonstrated with a yeast gene expression data set and with two database classifications. The obtained clusters demonstrated a very strong enrichment of functional classes. The obtained clusters are also able to present similar gene groups to those that were observed from the data set in the original analysis and also many gene groups that were not reported in the original analysis. Visualization of the results on top of a cluster tree shows that the method finds informative clusters from several levels of the cluster tree and indicates that the clusters found could not have been obtained by simply cutting the cluster tree. Results were also used in the comparison of cluster trees from different clustering methods. CONCLUSION: The presented method should facilitate the exploratory analysis of big data sets when the associated categorical data is available.},
affiliation = {A. I. Virtanen Institute for Molecular Sciences, Neulaniementie 2, P.O. Box 1627, FIN-70211 Kuopio, Finland. toronen@hytti.uku.fi},
pages = {32},
volume = {5},
year = {2004},
month = {Mar},
language = {eng},
keywords = {Genes: Fungal, Computational Biology, Gene Expression Profiling, Saccharomyces cerevisiae, Random Allocation, Cluster Analysis, Gene Expression Regulation: Fungal},
date-added = {2010-01-03 12:23:05 +0100},
date-modified = {2010-01-03 12:23:05 +0100},
doi = {10.1186/1471-2105-5-32},
pii = {1471-2105-5-32},
pmid = {15043761},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Toronen-2004-BMC%20Bioinformatics_Selection%20of%20informa.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p426},
rating = {0}
}

@article{Heath:1990p5518,
author = {A C Heath and N G Martin},
journal = {J Pers Soc Psychol},
title = {Psychoticism as a dimension of personality: a multivariate genetic test of Eysenck and Eysenck's psychoticism construct},
abstract = {In this study, we applied multivariate genetic analysis, a generalization of factor analysis and behavior genetic analysis, to responses to items of the Psychoticism scale of the Eysenck Personality Questionnaire by 2,903 adult same-sex Australian twin pairs. Item loadings on genetic, shared environmental, and nonshared environmental common and specific factors were estimated. The genetic factor structure differed considerably from the environmental structures, particularly in men. The genetic correlation between suspiciousness items and items reflecting unconventional or tough-minded attitudes or hostility to others was negative, but the environmental correlation was positive. Thus, conventional behavior genetic studies that have reported significant heritability of psychoticism, on the basis of analyses of scale scores, are misleading as to what trait is being inherited.},
affiliation = {Department of Human Genetics, Medical College of Virginia.},
number = {1},
pages = {111--21},
volume = {58},
year = {1990},
month = {Jan},
language = {eng},
keywords = {Adult, Personality Tests, Phenotype, Twins: Dizygotic, Humans, Social Environment, Models: Genetic, Twins: Monozygotic, Psychotic Disorders, Risk Factors, Psychometrics, Diseases in Twins},
date-added = {2010-02-12 14:59:25 +0100},
date-modified = {2010-07-29 19:35:33 +0200},
pmid = {2308068},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5518},
rating = {4}
}

@article{Luijsterburg:2007p8367,
author = {Jan Luijsterburg and Joop van den Bogaard and Pieter de Vries Robb{\'e}},
journal = {BMC Psychiatry},
title = {Variety in mental health research data: when does more become too much?},
abstract = {BACKGROUND: Institutes for mental health care consider scientific research an important activity. A good way to stimulate research is by simplifying data collection. Creating a minimal data set for research purposes would be one way to achieve this, however, this would only be possible if the researchers use a limited variety of data types. This article will address the question whether or not this is the case. METHODS: Researchers working in Dutch mental health institutes were approached and asked to complete an internet questionnaire on the individual variables they collected for, and measurement instruments used in, their studies. RESULTS: In the 92 studies described by the researchers, 124 different variables were collected, and 223 different instruments were used. A total of 66% of the variables and 73% of the instruments were only used in one study. CONCLUSION: There is little commonality among research data, hence flexibility will be a crucial factor in facilitating data collection for research in mental health institutes. Nevertheless, reducing the variety of variables and instruments used is important to increase the comparability of results.},
affiliation = {Tranzo, Scientific Center for Transformation in Care and Welfare, Tilburg University, PO box 90153, 5000 LE Tilburg, the Netherlands. j.luijsterburg@ggzmb.nl},
pages = {45},
volume = {7},
year = {2007},
month = {Jan},
language = {eng},
keywords = {Research, Humans, Mental Health},
date-added = {2010-03-21 13:00:50 +0100},
date-modified = {2010-03-21 13:00:50 +0100},
doi = {10.1186/1471-244X-7-45},
pii = {1471-244X-7-45},
pmid = {17803813},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Luijsterburg-2007-BMC%20Psychiatry_Variety%20in%20mental%20he.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8367},
rating = {0}
}

@article{Nemoda:2010p11861,
author = {Zsofia Nemoda and Karlen Lyons-Ruth and Anna Szekely and Eszter Bertha and Gabor Faludi and Maria Sasvari-Szekely},
journal = {Behav Brain Funct},
title = {Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients},
abstract = {ABSTRACT: BACKGROUND: In the development of borderline personality disorder (BPD) both genetic and environmental factors have important roles. The characteristic affective disturbance and impulsive aggression are linked to imbalances in the central serotonin system, and most of the genetic association studies focused on serotonergic candidate genes. However, the efficacy of dopamine D2 receptor (DRD2) blocking antipsychotic drugs in BPD treatment also suggests involvement of the dopamine system in the neurobiology of BPD. METHODS: In the present study we tested the dopamine dysfunction hypothesis of impulsive self- and other-damaging behaviors: borderline and antisocial traits were assessed by Structured Clinical Interview for Diagnosis (SCID) for DSM-IV in a community-based US sample of 99 young adults from low-to-moderate income families. For the BPD trait analyses a second, independent group was used consisting of 136 Hungarian patients with bipolar or major depressive disorder filling out self-report SCID-II Screen questionnaire. In the genetic association analyses the previously indicated polymorphisms of the catechol-O-methyl-transferase (COMT Val158Met) and dopamine transporter (DAT1 40 bp VNTR) were studied. In addition, candidate polymorphisms of the DRD2 and DRD4 dopamine receptor genes were selected from the impulsive behavior literature. RESULTS: The DRD2 TaqI B1-allele and A1-allele were associated with borderline traits in the young adult sample (p = 0.001, and p = 0.005, respectively). Also, the DRD4 -616 CC genotype appeared as a risk factor (p = 0.02). With severity of abuse accounted for in the model, genetic effects of the DRD2 and DRD4 polymorphisms were still significant (DRD2 TaqIB: p = 0.001, DRD2 TaqIA: p = 0.008, DRD4 -616 C/G: p = 0.002). Only the DRD4 promoter finding was replicated in the independent sample of psychiatric inpatients (p = 0.007). No association was found with the COMT and DAT1 polymorphisms. CONCLUSIONS: Our results of the two independent samples suggest a possible involvement of the DRD4 -616 C/G promoter variant in the development of BPD traits. In addition, an association of the DRD2 genetic polymorphisms with impulsive self-damaging behaviors was also demonstrated.},
affiliation = {Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary. zsofia.nemoda@eok.sote.hu.},
pages = {4},
volume = {6},
year = {2010},
month = {Jan},
language = {eng},
date-added = {2010-05-23 11:45:12 +0200},
date-modified = {2010-07-29 19:18:41 +0200},
doi = {10.1186/1744-9081-6-4},
pii = {1744-9081-6-4},
pmid = {20205808},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Nemoda-2010-Behav%20Brain%20Funct_Association%20between.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11861},
rating = {0}
}

@article{Polderman:2010p5660,
author = {T J C Polderman and M Bartels and F C Verhulst and A C Huizink and C E M van Beijsterveldt and Dorret I Boomsma},
journal = {J Epidemiol Community Health},
title = {No effect of classroom sharing on educational achievement in twins: a prospective, longitudinal cohort study},
abstract = {BACKGROUND: A returning dilemma for families with multiple births is whether twins should share the same, or a parallel classroom, or in other words, whether they should be separated at school or not. This study investigated the effects of sharing a classroom during primary school on cognitive achievement in twins. METHOD: Subjects were 839 monozygotic and 1164 dizygotic twin pairs who were registered at birth at The Netherlands Twin Register. A prospective, longitudinal study design was used with educational achievement at age 12 years, measured with a standardised test (CITO test), as outcome measure. RESULTS: Most twin pairs (72%) shared a classroom during their schooling, 19% were in separate, but parallel, classes, and 9% "partly" shared a classroom. Twins who were in parallel classrooms had higher CITO scores (mean 539.51; SD 8.12), compared to twins who shared a classroom (537.99; SD 8.52). When controlling for socioeconomic status, and externalising problems before starting primary school (age 3), there was no significant difference in educational achievement between separated and non-separated twin pairs (p = 0.138). In addition, there was no interaction with sex or zygosity of the twins (p = 0.798). CONCLUSION: There is no difference in educational achievement between twins who share a classroom and twins who do not share a classroom during their primary school time. The choice of separation should be made by teachers, parents and their twin children, based on individual characteristics of a twin pair.},
affiliation = {Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands. jc.polderman@psy.vu.nl},
number = {1},
pages = {36--40},
volume = {64},
year = {2010},
month = {Jan},
language = {eng},
date-added = {2010-02-12 20:23:23 +0100},
date-modified = {2010-07-29 20:25:51 +0200},
doi = {10.1136/jech.2009.091629},
pii = {64/01/36},
pmid = {20007633},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Polderman-2010-J%20Epidemiol%20Community%20Health_No%20effect%20of%20classro.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5660},
rating = {0}
}

@article{Kocalevent:2009p7354,
author = {R{\"u}ya-Daniela Kocalevent and Matthias Rose and Janine Becker and Otto B Walter and Herbert Fliege and Jakob B Bjorner and Dieter Kleiber and Burghard F Klapp},
journal = {Journal of Clinical Epidemiology},
title = {An evaluation of patient-reported outcomes found computerized adaptive testing was efficient in assessing stress perception},
abstract = {OBJECTIVES: This study aimed to develop and evaluate a first computerized adaptive test (CAT) for the measurement of stress perception (Stress-CAT), in terms of the two dimensions: exposure to stress and stress reaction. STUDY DESIGN AND SETTING: Item response theory modeling was performed using a two-parameter model (Generalized Partial Credit Model). The evaluation of the Stress-CAT comprised a simulation study and real clinical application. A total of 1,092 psychosomatic patients (N1) were studied. Two hundred simulees (N2) were generated for a simulated response data set. Then the Stress-CAT was given to n=116 inpatients, (N3) together with established stress questionnaires as validity criteria. RESULTS: The final banks included n=38 stress exposure items and n=31 stress reaction items. In the first simulation study, CAT scores could be estimated with a high measurement precision (SE<0.32; rho>0.90) using 7.0+/-2.3 (M+/-SD) stress reaction items and 11.6+/-1.7 stress exposure items. The second simulation study reanalyzed real patients data (N1) and showed an average use of items of 5.6+/-2.1 for the dimension stress reaction and 10.0+/-4.9 for the dimension stress exposure. Convergent validity showed significantly high correlations. CONCLUSIONS: The Stress-CAT is short and precise, potentially lowering the response burden of patients in clinical decision making.},
affiliation = {Clinic for Internal Medicine, Department of Psychosomatic Medicine and Psychotherapy, Charit{\'e} University Medicine Berlin, Berlin, Germany. rueya.kocalevent@fu-berlin.de},
number = {3},
pages = {278-87, 287.e1--3},
volume = {62},
year = {2009},
month = {Mar},
language = {eng},
keywords = {Aged: 80 and over, Confidence Intervals, Quality of Health Care, Questionnaires, Reproducibility of Results, Stress: Psychological, Female, Humans, Adult, Adolescent, Male, Perception, Sickness Impact Profile, Middle Aged, Aged, Treatment Outcome, Diagnosis: Computer-Assisted},
date-added = {2010-03-10 20:25:21 +0100},
date-modified = {2010-03-10 20:25:21 +0100},
doi = {10.1016/j.jclinepi.2008.03.003},
pii = {S0895-4356(08)00090-5},
pmid = {18639439},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Kocalevent-2009-Journal%20of%20Clinical%20Epidemiology_An%20evaluation%20of%20pat.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7354},
rating = {0}
}

@article{Lung:2004p13088,
author = {For-Wey Lung and Yi-Lin Huang and Bih-Ching Shu and Fei-Yin Lee},
journal = {Compr Psychiatry},
title = {Parental rearing style, premorbid personality, mental health, and quality of life in chronic regional pain: A causal analysis},
abstract = {The aim of the current study was to establish the causal model among parental bonding, personality characteristics, mental health, quality of life, and chronic regional pain (CRP). Thirty CRP patients and 56 mental illness patients were compared using the Visual Analogue Scale (VAS), Chinese Health Questionnaire (CHQ), Eysenck Personality Questionnaire (EPQ), World Health Organization Quality of Life-Brief-Tawain Version (WHOQOL-BREF-TW), and Parental Bonding Instrument (PBI). There were significant differences in mental health, personality characteristics, and quality of life between the CRP and mental illness groups. Structural equation modeling showed that parental bonding could directly affect personality characteristics, and, hence, directly impact disease and quality of life. CRP is different from mental illness in many dimensions. In this study, CRP appeared to be caused by actual physical dysfunction rather than mental dysfunction.},
affiliation = {Department of Psychiatry, Military Kaohsiung General Hospital, Kaohsiung City, and Institute of Allied Health Sciences and School of Nursing, National Cheng Kung University, Taiwan City, Taiwan.},
number = {3},
pages = {206--12},
volume = {45},
year = {2004},
month = {Jan},
language = {eng},
keywords = {Questionnaires, Pain Measurement, Mental Disorders, Child: Preschool, Logistic Models, Extraversion (Psychology), Quality of Life, Middle Aged, Child Rearing, Sex Factors, Object Attachment, Case-Control Studies, Taiwan, Mental Health, Models: Psychological, Humans, Parent-Child Relations, Personality Assessment, Chronic Disease, Pain},
date-added = {2010-06-26 10:18:44 +0200},
date-modified = {2010-07-29 19:24:13 +0200},
doi = {10.1016/j.comppsych.2004.02.009},
pii = {S0010440X04000240},
pmid = {15124151},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Lung-2004-Compr%20Psychiatry_Parental%20rearing%20sty.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13088},
rating = {0}
}

@article{GomezBenito:2009p535,
author = {Juana Gomez-Benito and M Dolores Hidalgo and Jose-Luis Padilla},
journal = {Methodology},
title = {Efficacy of Effect Size Measures in Logistic Regression. An Application for Detecting DIF},
abstract = {Statistical techniques based on logistic regression (LR) are adequate for the detection of differential item functioning (DIF) in dichotomous items. Nevertheless, they return more false positives (FPs) than do other DIF detection techniques. This paper compares the efficacy of DIF detection using the LR significance test and the estimation of the effect size that these procedures provide using R2 of Nagelkerke. The variables manipulated were different conditions of sample size, focal and reference group sample size ratio, amount of DIF, test length and percentage of test items with DIF. In addition, examinee responses were generated to simulate both uniform and nonuniform DIF (symmetric and asymmetric). In all cases, dichotomous response tests were used. The results show that the use of R2 as a strategy for detecting DIF obtained lower correct detection percentages than those obtained from significance tests. Moreover, the LR significance test showed adequate control of FP rates, close to the nominal 5%, although the rate was slightly higher than the nominal 5% when the sample size was smaller. However, when the effect size measure was used to detect DIF, the FP rates were lower and <1% for a wide number of conditions. In addition, a statistically significant main effect of the sample size variable was obtained. Thus, the FP percentages were higher when the sample size was small (100/100). The results obtained indicate that the use of R2 as a measure of effect size together with the statistical significance test reduces the rate of FP.},
affiliation = {University of Barcelona, Spain},
number = {1},
pages = {18--25},
volume = {5},
year = {2009},
keywords = {logistic regression analysis, R2 of Nagelkerke, differential item functioning, effect size measure},
date-added = {2010-01-03 13:51:36 +0100},
date-modified = {2010-07-29 20:04:05 +0200},
doi = {10.1027/1614-2241.5.1.18},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Gomez-Benito-2009-Methodology_Efficacy%20of%20Effect%20S.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p535},
rating = {0}
}

@article{McCarthy:2009p5447,
author = {Denis M McCarthy and Sarah L Pedersen and Elizabeth J D'Amico},
journal = {Psychol Assess},
title = {Analysis of item response and differential item functioning of alcohol expectancies in middle school youths},
abstract = {Drinking behavior in preadolescence is a significant predictor of both short- and long-term negative consequences. This study examined the psychometric properties of 1 known risk factor for drinking in this age group, alcohol expectancies, within an item response theory framework. In a sample of middle school youths (N = 1,273), the authors tested differential item functioning (DIF) in positive and negative alcohol expectancies across grade, gender, and ethnicity. Multiple-indicator multiple-cause model analyses tested differences in alcohol use as a potential explanation for observed DIF across groups. Results showed that most expectancy items did not exhibit DIF. For items where DIF was indicated, differences in alcohol use did not explain differences in item parameters. Positive and negative expectancies also systematically differed in the location parameter. Latent variable scale scores of both positive and negative expectancies were associated with drinking behavior cross-sectionally, while only positive expectancies predicted drinking prospectively. Improving the measurement of alcohol expectancies can help researchers better assess this important risk factor for drinking in this population, particularly the identification of those with either very high positive or very low negative alcohol expectancies.},
affiliation = {Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA. mccarthydm@missouri.edu},
number = {3},
pages = {444--9},
volume = {21},
year = {2009},
month = {Sep},
language = {eng},
keywords = {California, Female, Alcohol Drinking, Child Behavior, Cross-Sectional Studies, Factor Analysis: Statistical, Ethnic Groups, Questionnaires, Child, Humans, Risk Factors, Male, Analysis of Variance, Psychometrics},
date-added = {2010-02-12 14:09:17 +0100},
date-modified = {2010-07-29 19:45:39 +0200},
doi = {10.1037/a0016319},
pii = {2009-12887-019},
pmid = {19719355},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5447},
rating = {0}
}

@article{Bottomley:2009p8808,
author = {Andrew Bottomley and Dave Jones and Lily Claassens},
journal = {Eur J Cancer},
title = {Patient-reported outcomes: assessment and current perspectives of the guidelines of the Food and Drug Administration and the reflection paper of the European Medicines Agency},
abstract = {AIMS: Patient-reported outcomes (PROs) have recently gained greater credibility with regulatory bodies aiming to standardise their use and interpretation in RCTs, thereby supporting medicinal product submissions. For this reason, the United States (US) Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) have released guidelines. This review paper provides an overview of the current perspectives and views on these guidelines. METHOD: To evaluate the FDA and EMEA PRO guidelines, 47 expert responses to the FDA guidance were qualitatively reviewed. Two reviewers independently extracted data from these letters and checked these responses to warrant consistency and agreement in the evaluation process. A PubMed literature review was systematically examined to obtain supporting evidence or related articles for both the guidance documents. RESULTS: Generally, there is agreement between regulatory authorities and the research community on the contents of the FDA and EMEA PRO draft guidance. However, disagreements exist on significant philosophical topics (e.g. the FDA focuses more on conceptual models and symptoms than the EMEA) and design topics (e.g. the FDA is more restrictive on issues of recall bias, blinding of oncology trials and degrees of psychometric validation than researchers and the EMEA). This could influence the approval of PRO claims. CONCLUSION: PRO guidance from the EMEA and FDA has been valuable, and has raised the profile and active debate of PROs in oncology. However, our review of the current opinion shows that there are controversial aspects of the guidance. Consequently, greater latitude should be given to how the guidance is interpreted and applied.},
affiliation = {EORTC Quality of Life Department, EORTC Headquarters, Avenue E. Mounierlaan, 83/11, Brussels 1200, Belgium. andrew.bottomley@eortc.be},
number = {3},
pages = {347--53},
volume = {45},
year = {2009},
month = {Feb},
language = {eng},
keywords = {Humans, United States Food and Drug Administration, Quality of Life, Health Status, Drug Approval, Practice Guidelines as Topic, Male, Clinical Trials as Topic, Outcome Assessment (Health Care), Patient Satisfaction, Oncology Service: Hospital, Reproducibility of Results, Female, Europe, United States},
date-added = {2010-03-22 12:09:47 +0100},
date-modified = {2010-03-22 12:09:47 +0100},
doi = {10.1016/j.ejca.2008.09.032},
pii = {S0959-8049(08)00792-2},
pmid = {19013787},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Bottomley-2009-Eur%20J%20Cancer_Patient-reported%20out.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8808},
rating = {0}
}

@article{Streiner:2006p7504,
author = {David L Streiner and Geoffrey R Norman},
journal = {Journal of Clinical Epidemiology},
title = {"Precision" and "accuracy": two terms that are neither},
abstract = {OBJECTIVE: In some publications, the terms "precision" and "accuracy" are used as if they were synonyms for "reliability" and "validity." METHODS AND RESULTS: This article shows that these terms are neither precise nor accurate when used in this way. Scales can demonstrate high test-retest or interrater reliability (i.e., they are "precise") but still be unreliable in certain circumstances; and "imprecise" scales can still show good reliability. Further, "accuracy" as a synonym for validity reflects an outdated conceptualization of validity, which has been superseded by one that emphasizes that validity tells us what conclusions can be drawn about a person based on a test result. CONCLUSION: The article ends with a call for the use of the more traditional terms as better reflecting the process of scale development and the uses to which they are put.},
affiliation = {Baycrest Centre for Geriatric Care, Department of Psychiatry, Kunin-Lunenfeld Applied Research Unit, University of Toronto, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada. dstreiner@klaru-baycrest.on.ca},
number = {4},
pages = {327--30},
volume = {59},
year = {2006},
month = {Apr},
language = {eng},
keywords = {Health Status Indicators, Terminology as Topic, Humans, Reproducibility of Results, Observer Variation},
date-added = {2010-03-10 20:46:08 +0100},
date-modified = {2010-03-10 20:46:14 +0100},
doi = {10.1016/j.jclinepi.2005.09.005},
pii = {S0895-4356(05)00340-9},
pmid = {16549250},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Streiner-2006-Journal%20of%20Clinical%20Epidemiology_%22Precision%22%20and%20%22acc.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7504},
rating = {5}
}

@article{Fidler:2006p8600,
author = {Deborah J Fidler and Susan Hepburn and Sally Rogers},
journal = {Downs Syndr Res Pract},
title = {Early learning and adaptive behaviour in toddlers with Down syndrome: evidence for an emerging behavioural phenotype?},
abstract = {BACKGROUND: Though the Down syndrome behavioural phenotype has been described as involving relative strengths in visuo-spatial processing and sociability, and relative weaknesses in verbal skills and motor planning, the early emergence of this phenotypic pattern of strengths and weaknesses has not yet been fully explored. METHOD: In this study, we compared the performance of eighteen 2 to 3-year-olds with Down syndrome to an MA-matched comparison group of nineteen 2 to 3-year-olds with mixed developmental disabilities, and an MA-matched comparison group of 24 children with typical development on two developmental measures: the Mullen Scales of Early Learning and the Vineland Adaptive Behaviour Scales. RESULTS: While the specificity of the Down syndrome profile was (for the most part) not yet evident, results showed that toddlers with Down syndrome in this study did show emerging areas of relative strength and weakness similar to that which has been described in older children and young adults with Down syndrome. This pattern included relatively stronger social skills, weaker expressive language, and poor motor coordination. When this pattern of strengths and weaknesses was compared to the developmental profiles of the two comparison groups, socialisation strengths differentiated the Down syndrome group from the mixed developmental disabilities group.},
affiliation = {Human Development and Family Studies, Colorado State University, USA. Deborah.Fidler@colostate.edu},
number = {3},
pages = {37--44},
volume = {9},
year = {2006},
month = {Jun},
language = {eng},
keywords = {Socialization, Adaptation: Psychological, Male, Socioeconomic Factors, Phenotype, Social Behavior, Down Syndrome, Visual Perception, Female, Child: Preschool, Child Behavior, Psychological Tests, Longitudinal Studies, Infant, Motor Skills, Humans, Developmental Disabilities, Language Development, Learning},
date-added = {2010-03-22 00:24:28 +0100},
date-modified = {2010-03-22 00:24:28 +0100},
pmid = {16869373},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Fidler-2006-Downs%20Syndr%20Res%20Pract_Early%20learning%20and%20a.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8600},
rating = {0}
}

@article{PsychiatricGWASConsortiumCoordinatingCommittee:2009p816,
author = {Psychiatric GWAS Consortium Coordinating Committee and Sven Cichon and Nick Craddock and Mark Daly and Stephen V Faraone and Pablo V Gejman and John Kelsoe and Thomas Lehner and Douglas F Levinson and Audra Moran and Pamela Sklar and Patrick F Sullivan},
journal = {Am J Psychiatry},
title = {Genomewide association studies: history, rationale, and prospects for psychiatric disorders},
abstract = {OBJECTIVE: The authors conducted a review of the history and empirical basis of genomewide association studies (GWAS), the rationale for GWAS of psychiatric disorders, results to date, limitations, and plans for GWAS meta-analyses. METHOD: A literature review was carried out, power and other issues discussed, and planned studies assessed. RESULTS: Most of the genomic DNA sequence differences between any two people are common (frequency >5%) single nucleotide polymorphisms (SNPs). Because of localized patterns of correlation (linkage disequilibrium), 500,000 to 1,000,000 of these SNPs can test the hypothesis that one or more common variants explain part of the genetic risk for a disease. GWAS technologies can also detect some of the copy number variants (deletions and duplications) in the genome. Systematic study of rare variants will require large-scale resequencing analyses. GWAS methods have detected a remarkable number of robust genetic associations for dozens of common diseases and traits, leading to new pathophysiological hypotheses, although only small proportions of genetic variance have been explained thus far and therapeutic applications will require substantial further effort. Study design issues, power, and limitations are discussed. For psychiatric disorders, there are initial significant findings for common SNPs and for rare copy number variants, and many other studies are in progress. CONCLUSIONS: GWAS of large samples have detected associations of common SNPs and of rare copy number variants with psychiatric disorders. More findings are likely, since larger GWAS samples detect larger numbers of common susceptibility variants, with smaller effects. The Psychiatric GWAS Consortium is conducting GWAS meta-analyses for schizophrenia, bipolar disorder, major depressive disorder, autism, and attention deficit hyperactivity disorder. Based on results for other diseases, larger samples will be required. The contribution of GWAS will depend on the true genetic architecture of each disorder.},
number = {5},
pages = {540--56},
volume = {166},
year = {2009},
month = {May},
language = {eng},
keywords = {Phenotype, Genome, Linkage Disequilibrium, Mental Disorders, History: 21st Century, Linkage (Genetics), Humans, History: 20th Century, Alleles, Polymorphism: Single Nucleotide},
date-added = {2010-01-03 17:25:51 +0100},
date-modified = {2010-01-03 17:25:51 +0100},
doi = {10.1176/appi.ajp.2008.08091354},
pii = {appi.ajp.2008.08091354},
pmid = {19339359},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Psychiatric%20GWAS%20Consortium%20Coordinating%20Committee-2009-Am%20J%20Psychiatry_Genomewide%20associati.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p816},
read = {Yes},
rating = {0}
}

@article{Leveille:2005p3626,
author = {J Leveille and J Leveille},
journal = {SUGI 30},
title = {Sexy SAS/IntrNet{\textregistered}: A Macromedia Flash front-end for SAS{\textregistered} Web Applications},
abstract = {Many of us remember the ``eureka'' effect we experienced the first time we saw a SAS/IntrNet application come to life and connect SAS Software to the web browser. For some of us that was as many as seven years ago. Since that time, the landscape of the Internet has changed drastically. Web applications are everywhere and the capabilities of these applications, as well as the look and feel of their associated web sites, has steadily improved.
The ubiquitous Flash{\textregistered} player from Macromedia{\textregistered} has emerged as a leading technology for developing next generation web sites and application user interfaces. With Flash you can leap beyond the limitations of the web browser and have a fast, dynamic, customizable user interface at your disposal.
This paper demonstrates how you can utilize Flash functionality in order to create a dynamic, platform-independent web application that is configured and driven by SAS Software.},
year = {2005},
date-added = {2010-01-16 18:53:27 +0100},
date-modified = {2010-01-16 18:54:49 +0100},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Leveille-2005-SUGI%2030_Sexy%20SASIntrNet%C2%AE%20A.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3626},
rating = {0}
}

@article{Lopes:2003p13126,
author = {P N Lopes and P Salovey and R Straus},
journal = {Personality and Individual Differences},
title = {Emotional intelligence, personality, and the perceived quality of social relationships},
abstract = {This study explored links between emotional intelligence, measured as a set of abilities, and personality traits, as well as the contribution of both to the perceived quality of one's interpersonal relationships. In a sample of 103 college students, we found that both emotional intelligence and personality traits were associated with concurrent self-reports of satisfaction with social relationships. Individuals scoring highly on the managing emotions subscale of the Mayer, Salovey, and Caruso Emotional Intelligence Test (MSCEIT), were more likely to report positive relations with others, as well as perceived parental support, and less likely to report negative interactions with close friends. These associations remained statistically significant even controlling for significant Big Five personality traits and verbal intelligence. Global satis- faction with one's relationships was associated with extraversion, neuroticism (negatively), and the ability to manage one's emotions, as assessed by the MSCEIT.},
pages = {641--658},
volume = {35},
year = {2003},
date-added = {2010-06-26 10:51:58 +0200},
date-modified = {2010-06-26 10:53:04 +0200},
pii = {S0191-8869(02)00242-8},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Lopes-2003-Personality%20and%20Individual%20Differences_Emotional%20intelligen.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13126},
rating = {0}
}

@article{Morton:2007p3884,
author = {Newton Morton and Nikolas Maniatis and Weihua Zhang and Sarah Ennis and Andrew Collins},
journal = {Am J Hum Genet},
title = {Genome scanning by composite likelihood},
abstract = {Ambitious programs have recently been advocated or launched to create genomewide databases for meta-analysis of association between DNA markers and phenotypes of medical and/or social concern. A necessary but not sufficient condition for success in association mapping is that the data give accurate estimates of both genomic location and its standard error, which are provided for multifactorial phenotypes by composite likelihood. That class includes the Malecot model, which we here apply with an illustrative example. This preliminary analysis leads to five inferences: permutation of cases and controls provides a test of association free of autocorrelation; two hypotheses give similar estimates, but one is consistently more accurate; estimation of the false-discovery rate is extended to causal genes in a small proportion of regions; the minimal data for successful meta-analysis are inferred; and power is robust for all genomic factors except minor-allele frequency. An extension to meta-analysis is proposed. Other approaches to genome scanning and meta-analysis should, if possible, be similarly extended so that their operating characteristics can be compared.},
affiliation = {Human Genetics Division, University of Southampton, Southampton General Hospital, Southampton ,SO16 6YD, UK. nem@soton.ac.uk},
number = {1},
pages = {19--28},
volume = {80},
year = {2007},
month = {Jan},
language = {eng},
keywords = {Meta-Analysis as Topic, Models: Theoretical, Humans, Genome: Human, Genetic Markers, Chromosome Mapping},
date-added = {2010-01-16 21:03:55 +0100},
date-modified = {2010-01-16 21:03:55 +0100},
doi = {10.1086/510401},
pii = {S0002-9297(07)60918-5},
pmid = {17160891},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3884},
rating = {0}
}

@article{Huh:2008p1771,
author = {Jimi Huh and Jo Ann Prause and C David Dooley},
journal = {Journal of immigrant and minority health / Center for Minority Public Health},
title = {The impact of nativity on chronic diseases, self-rated health and comorbidity status of Asian and Hispanic immigrants},
abstract = {This study examines the physical health status of immigrants with specific considerations of Asian and Hispanic populations and explores possible mechanisms through which health outcomes of interest can be explained. Analyses of the National Health Interview Surveys (NHIS) of 2000 and 2001 revealed that foreign-born individuals reported fewer chronic diseases (hypertension, heart disease, asthma, cancer and diabetes) and had lower prevalences of various chronic diseases compared with U.S.-born whites, controlling for possible confounders and mediators. However, U.S-born minority groups did not show the health advantage seen in foreign-born immigrants, reflecting the importance of nativity distinctions in studying immigrant health. Despite having fewer chronic diseases, foreign-born Asians were more likely to rate their health negatively relative to their U.S.-born counterparts and to U.S.-born whites. In addition, our findings provide evidence that failure to consider comorbid status may attenuate the nativity effect on certain chronic diseases.},
affiliation = {Department of Psychology and Social Behavior, University of California at Irvine, 3340 Social Ecology Building II, Irvine, CA 92697-7085, USA. huhj@uci.edu},
number = {2},
pages = {103--18},
volume = {10},
year = {2008},
month = {Apr},
language = {eng},
keywords = {Hispanic Americans, Middle Aged, Asian Americans, Adult, Chronic Disease, Female, Risk Factors, Male, Health Status Disparities, Humans, Health Behavior, Emigrants and Immigrants, Comorbidity, Socioeconomic Factors},
date-added = {2010-01-09 21:31:58 +0100},
date-modified = {2010-01-09 21:31:58 +0100},
doi = {10.1007/s10903-007-9065-7},
pmid = {17546500},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1771},
rating = {0}
}

@article{Box:1980p11754,
author = {G E P Box},
journal = {Journal of the Royal Society, Serie A},
title = {Sampling and Bayes' Inference in Scientific Modelling and Robustness},
number = {4},
pages = {383--430},
volume = {143},
year = {1980},
date-added = {2010-05-23 09:53:46 +0200},
date-modified = {2010-05-23 09:54:54 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Box-1980-Journal%20of%20the%20Royal%20Society%20Serie%20A_Sampling%20and%20Bayes'.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11754},
rating = {0}
}

@article{Mevik:2007p12909,
author = {B H Mevik and R Wehrens},
journal = {Journal of Statistical Software},
title = {The pls Package: Principal Component and Partial Least Squares Regression in R},
abstract = {The pls package implements principal component regression (PCR) and partial least squares regression (PLSR) in R (R Development Core Team 2006b), and is freely available from the Comprehensive R Archive Network (CRAN), licensed under the GNU General Public License (GPL).
The user interface is modelled after the traditional formula interface, as exemplified by lm. This was done so that people used to R would not have to learn yet another interface, and also because we believe the formula interface is a good way of working interactively with models. It thus has methods for generic functions like predict, update and coef. It also has more specialised functions like scores, loadings and RMSEP, and a flexible cross- validation system. Visual inspection and assessment is important in chemometrics, and the pls package has a number of plot functions for plotting scores, loadings, predictions, coefficients and RMSEP estimates.
The package implements PCR and several algorithms for PLSR. The design is modular, so that it should be easy to use the underlying algorithms in other functions. It is our hope that the package will serve well both for interactive data analysis and as a building block for other functions or packages using PLSR or PCR.
We will here describe the package and how it is used for data analysis, as well as how it can be used as a part of other packages. Also included is a section about formulas and data frames, for people not used to the R modelling idioms.},
number = {2},
volume = {18},
year = {2007},
date-added = {2010-06-24 17:38:25 +0200},
date-modified = {2010-06-24 17:39:10 +0200},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Mevik-2007-Journal%20of%20Statistical%20Software_The%20pls%20Package%20Pri.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12909},
rating = {0}
}

@article{Avery:2006p11370,
author = {C L Avery and B I Freedman and A T Kraja and I B Borecki and M B Miller and J S Pankow and D Arnett and C E Lewis and R H Myers and S C Hunt and K E North},
journal = {Diabetologia},
title = {Genotype-by-sex interaction in the aetiology of type 2 diabetes mellitus: support for sex-specific quantitative trait loci in Hypertension Genetic Epidemiology Network participants},
abstract = {AIMS/HYPOTHESIS: While there are sex-related differences in both the prevalence of type 2 diabetes mellitus and disease risk factors, there is only limited research on sex-specific influences on type 2 diabetes aetiology within the same study population. Thus, we assessed genotype-by-sex interaction using a liability threshold model in an attempt to localise sex-specific type 2 diabetes quantitative trait loci (QTLs). SUBJECTS, MATERIALS AND METHODS: Hypertensive siblings and their offspring and/or parents in the Hypertension Genetic Epidemiology Network of the Family Blood Pressure Program were recruited from five field centres. The diabetic phenotype was adjusted for race, study centre, age and non-linear age effects. In total, 567 diabetic individuals were identified in 385 families. Variance component linkage analyses in the combined sample and stratified by sex and race were performed (SOLAR program) using race-specific marker allele frequencies derived from a random sample of participants at each centre. RESULTS: We observed a QTL-specific genotype-by-sex interaction (p=0.009) on chromosome 17 at 31 cM, with females displaying a robust adjusted logarithm of odds (LOD) of 3.0 compared with 0.2 in males and 1.3 in the combined sample. Three additional regions demonstrating suggestive evidence for linkage were detected: chromosomes 2 and 5 in the female sample and chromosome 22 (adjusted LOD=1.9) in the combined sample. CONCLUSIONS/INTERPRETATION: These findings suggest that multiple genes may regulate susceptibility to type 2 diabetes, demonstrating the importance of considering the interaction of genes and environment in the aetiology of common complex traits.},
affiliation = {Department of Epidemiology, CB {\#}8050, The University of North Carolina, Chapel Hill, NC 27514, USA.},
number = {10},
pages = {2329--36},
volume = {49},
year = {2006},
month = {Oct},
language = {eng},
keywords = {Humans, Genotype, Adult, United States, Sex Characteristics, Aged, Hypertension, Female, Nuclear Family, Middle Aged, Risk Factors, Phenotype, Diabetes Mellitus: Type 2, Male, Continental Population Groups, Quantitative Trait Loci, Prevalence},
date-added = {2010-04-26 23:09:00 +0200},
date-modified = {2010-04-26 23:09:01 +0200},
doi = {10.1007/s00125-006-0375-4},
pmid = {16906437},
local-url = {file://localhost/Users/chl/Dropbox/Papers/Avery-2006-Diabetologia_Genotype-by-sex%20inte.pdf},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11370},
rating = {0}
}

@article{Anderson:2008p5437,
author = {Emily R Anderson and Debra A Hope},
journal = {Clin Psychol Rev},
title = {A review of the tripartite model for understanding the link between anxiety and depression in youth},
abstract = {Although research from numerous investigations indicates that there is substantial overlap in anxiety and depressive symptoms and comorbid diagnoses in youth, these constructs can be adequately differentiated. Clark and Watson [Clark, L. A. {\&} Watson, D., (1991). Tripartite model of anxiety and depression: Psychometric evidence and taxonomic implications. Journal of Abnormal Psychology, 100, 316-336] proposed a tripartite model to account for the symptom overlap and diagnostic comorbidity between anxiety and depression. This tripartite model posits that anxiety and depression share a common component of negative affect, but can be differentiated by low positive affect associated with depression and high physiological hyperarousal associated with anxiety. The present article reviews initial research which has supported the utility of the tripartite model for explaining the association between anxiety and depression in adult and youth samples. Following that review, more recent investigations which have called into question the applicability of the tripartite constructs for youth are presented. Finally, the paper reviews evidence suggesting that the tripartite factors may not function similarly across all anxiety and depressive disorders. This article concludes by suggesting that more research is necessary with children and adolescents in order to determine the functioning of tripartite constructs across anxiety disorders in youth.},
affiliation = {University of Nebraska-Lincoln, Department of Psychology, 238 Burnett Hall, Lincoln, NE 68588-0308, United States. anderso3@bigred.unl.edu},
number = {2},
pages = {275--87},
volume = {28},
year = {2008},
month = {Feb},
language = {eng},
keywords = {Models: Psychological, Child, Depressive Disorder, Arousal, Comorbidity, Questionnaires, Humans, Personality Assessment, Male, Anxiety Disorders, Female, Adolescent, Adult},
date-added = {2010-02-11 17:23:52 +0100},
date-modified = {2010-02-11 17:23:52 +0100},
doi = {10.1016/j.cpr.2007.05.004},
pii = {S0272-7358(07)00104-3},
pmid = {17582665},
uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5437},
rating = {0}
}

@article{Simon:2010p9604,
author = {Joe J Simon and Stephan Walther and Christian J Fiebach and Hans-Christoph Friederich and Christoph Stippich and Matthias Weisbrod and Stefan Kaiser},
journal = {Neuroimage},
title = {Neural reward processing is modulated by approach- and avoidance-related personality traits},
abstract = {The neural processing of reward can be differentiated into two sub-components with different functions, "wanting" (i.e., the expectation of a reward which includes appetitive and motivational components) and "liking" (i.e., the hedonic impact experienced during the receipt of a reward), involving distinct neural systems. We hypothesize that variability in neural reward processing previously observed in healthy subjects could reflect inter-individual differences in personality. Therefore, the aim of this study was to investigate how the neural processing during expectation and reception of a reward depends on interpersonal differences in reward sensitivity, more specifically the tendency to approach vs. avoid reward-related situations. We employed event-related functional magnetic resonance imaging during a monetary incentive delay task. Subjects with a high approach motivation showed more activation of the Ventral Striatum (VS) during the receipt of a reward, and more medial orbitofrontal activity during both the receipt and omission of a reward. Subjects with a high behavioral inhibition showed less activation in the VS during the receipt of a reward. These findings indicate that the tendency to approach or avoid reward-related situations exhibits a distinct relation with neural reward processing. Specifically, subjects with high behavioral approach appear to be sensitive mainly to positive outcomes and to a lesser extent to the omissions of rewards, whereas subjects with low behavioral approach as well as those with a high inhibition tendency display a blunted response to rewards.},
affiliation = {Section of Experimental Psychopathology, Department of Psychiatry, University of Heidelberg, Germany. joe.simon@psychologie.uni-heidelberg.de},
note = {genim},
number = {2},
pages = {1868--74},
volume = {49},
year = {2010},
month = {Jan},
language = {eng},
keywords = {Questionnaires, Reaction Time, Executive Function, Male, Psychometrics, Task Performance and Analysis, Brain Mapping, Female, Reward, Magnetic Resonance Imaging, Cues, Humans, Personality Tests, Brain, Neuropsychological Tests, Young Adult, Personality},
date-added = {201

license: MIT

license_type: permissive

branch_name: refs/heads/master

extension: bib