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Background ========== The relevance of solar power in the renewable energy field is constantly increasing due to its ready availability and to the fact that the available amount exceeds by several orders of magnitude the needs of the human race. The search for new materials with better performances than standard Si-ba...
{ "pile_set_name": "PubMed Central" }
Background ========== *Dicistroviridae* is a recently established family of small, non-enveloped viruses, containing a +ssRNA genome, and is classified under the order *Picornavirales*. This family contains 14 members classified within two genera, *Cripavirus* (type species *Cricket paralysis virus*, CrPV), and *Apara...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Around 7% of malignant neoplasms occur in the kidney; these include Wilms tumor (WT; also known as nephroblastoma), clear cell sarcoma of the kidney, malignant rhabdoid tumor, and renal cell carcinoma \[[@b1-crt-2019-313],[@b2-crt-2019-313]\]. WT is the most common primary kidney tumor in chi...
{ "pile_set_name": "PubMed Central" }
Introduction {#S0001} ============ Psoriatic arthritis (PsA) is a chronic, inflammatory musculoskeletal disease that is characterized by peripheral arthritis, enthesitis, dactylitis, and spondylitis with or without nail and skin lesions.[@CIT0001],[@CIT0002] It is a systemic disease that develops in up to 40% of psori...
{ "pile_set_name": "PubMed Central" }
1. Introduction =============== Meckel diverticulum (MD) is the most common congenital anomaly of the gastrointestinal tract.^\[[@R1]\]^ MD originates from an incomplete obliteration of the omphalomesenteric or vitelline duct, which occurs around the fifth week of gestation.^\[[@R2]\]^ It usually appears as a pouch, 3...
{ "pile_set_name": "PubMed Central" }
Due to restrictions imposed by the Medical Ethics Committee of the Erasmus University Medical Center, requests and inquiries may be sent to the Management Team of the Healthy Ageing and Intellectual Disability Study (<info.gvg@erasmusmc.nl>). Introduction {#sec005} ============ Intellectual disability is a disability...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Ifosfamide is a commonly used alkylating chemotherapeutic agent of the oxaphosphorines family that is often combined with other drugs, such as cisplatin, for the treatment of sarcomas \[[@sfz183-B1], [@sfz183-B2]\], testicular tumours \[[@sfz183-B3]\] and some refractory lymphomas \[[@sfz183-...
{ "pile_set_name": "PubMed Central" }
Background ========== Hypocalcemia is a disorder of mineral metabolism that occurs when PTH is insufficient to act on end organs (kidney, bone, intestine) -hypoparathyroidism, or end organs irresponsiveness in setting of sufficient PTH to normalize serum calcium -- PTH resistance. In the setting of adequately function...
{ "pile_set_name": "PubMed Central" }
Introduction {#cesec10} ============ Incomplete gallbladder surgery, involving leaving a long cystic duct or gallbladder remnant, for example, can occur in both open and laparoscopic procedures ([@bib1]). Incomplete surgery can lead to postcholecystectomy syndrome, which is a recurrence of symptoms similar to those th...
{ "pile_set_name": "PubMed Central" }
Excessive plasma triglyceride and cholesterol levels contribute to the development of several prevalent cardiovascular risk factors, such as hypertriglyceridemia, hypercholesterolemia, obesity and diabetes. Plasma triglyceride concentrations are maintained within a narrow range and exhibit circadian rhythmicity in huma...
{ "pile_set_name": "PubMed Central" }
Related literature {#sec1} ================== For the isostructural chloro analog, see: Sattarzadeh *et al.* (2009[@bb3]). Experimental {#sec2} ============ {#sec2.1} ### Crystal data {#sec2.1.1} (C~10~H~10~NO)\[ZnBr~2~(C~10~H~8~NO)\]·CH~4~O*M* *~r~* = 575.60Monoclinic,*a* = 9.9704 (8) Å*b* = 13.9954 (11) Å*c* = ...
{ "pile_set_name": "PubMed Central" }
###### Strengths and limitations of this study - This is the first study to assess the frequency and types of conflict of interest (COI) disclosed by authors of primary studies of health policy and systems research. - The study used a rigorous methodology that included a search strategy specific to health policy ...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized primarily by motor symptoms of bradykinesia, tremor, rigidity, and gait/postural disturbance. However, growing evidence suggests it may commonly lead to many non-motor psychiatric symptoms as well since at the ...
{ "pile_set_name": "PubMed Central" }
Background ========== Glass ionomer cements (GICs) are a class of biomaterial in widespread use in modern dentistry \[[@B1]\]. They are used for a multitude of applications including for filling cavities caused by tooth decay or wear, as cavity liners, as fissure sealants, and as cements to form an adhesive bond betwe...
{ "pile_set_name": "PubMed Central" }
The whole GCH array dataset is deposited in GEO Database (accession number GSE53440). Introduction {#sec001} ============ The yeast *Saccharomyces cerevisiae* can be found naturally in many niches in the environment, but it is most commonly known for its role as "baker's yeast" in either the traditional or industrial...
{ "pile_set_name": "PubMed Central" }
All relevant data are within the paper and its Supporting Information files. Introduction {#sec005} ============ In clinical practice, computed tomography (CT) has become an essential imaging modality for the diagnosis, sequential follow-up, and assessment of treatment response of intracranial diseases. Particularly,...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== Systemic sclerosis (SSc), also known as scleroderma, is a systemic autoimmune disease characterized by early inflammation and vascular injury followed by fibrosis of the skin and visceral organs \[[@CR1]--[@CR3]\]. Early SSc is dominated by immune cell activation, followed by secreting pr...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Along with surgery and chemotherapy, radiation therapy (RT) is an important modality in cancer treatment, with about half of cancer patients receiving RT as a curative or palliative treatment. However, there are still many challenges to improve its efficiency by minimizing normal tissue...
{ "pile_set_name": "PubMed Central" }
![](edinbmedsurgj71707-0082){#sp1 .73} ![](edinbmedsurgj71707-0083){#sp2 .74} ![](edinbmedsurgj71707-0084){#sp3 .75} ![](edinbmedsurgj71707-0085){#sp4 .76} ![](edinbmedsurgj71707-0086){#sp5 .77} ![](edinbmedsurgj71707-0087){#sp6 .78} ![](edinbmedsurgj71707-0088){#sp7 .79} ![](edinbmedsurgj71707-0089){#sp8 .80} ...
{ "pile_set_name": "PubMed Central" }
**Conflict of interests**: MA, YL, EG, NE, JL, MT, ED are employees of GenomeDx Biosciences. Dr. Lotan has received research funding for other projects from GenomeDx. Other authors declare no potential conflicts of interest. Adeno : prostatic adenocarcinoma ADT : androgen deprivation therapy AUC : area unde...
{ "pile_set_name": "PubMed Central" }
![](indmedgaz72698-0043){#sp1 .325}
{ "pile_set_name": "PubMed Central" }
Like human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2) causes AIDS-defining events, yet immunodeficiency and disease progression is far slower \[[@CIT0001], [@CIT0002]\]. Indeed, based on the definition of long-term nonprogressors used in HIV-1 infection, the proportion of people ...
{ "pile_set_name": "PubMed Central" }
*Vibrio vulnificus* is a highly invasive human pathogen and presents a food safety issue worldwide. Human infections caused by *V. vulnificus* are primarily caused by contaminated seafood consumption or contaminated skin wounds, which can lead to septicemia, wound infections, and high hospitalization and fatality rates...
{ "pile_set_name": "PubMed Central" }
**TO THE EDITOR:** Myelodysplastic syndromes (MDS) are a group of heterogeneous hematological malignancies which demand personalized and risk-adapted clinical management \[[@B1]\]. Current therapeutic approaches are rather limited for patients unsuitable for allogeneic stem cell transplantation (SCT), the only realisti...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Ecological theory suggests that predictions about population dynamics in planktonic systems have limited skill if intraspecific trait variation and heterogeneous resource distributions are ignored. Intraspecific trait variation within microalgal and bacterial populations has been shown ...
{ "pile_set_name": "PubMed Central" }
1. Introduction =============== G protein-coupled receptors (GPCRs) are a class of membrane proteins mediating important cellular signal transductions across the cell membrane. Structural studies for GPCRs have been conducted using X-ray crystallography and NMR spectroscopy \[[@B1-molecules-18-08579],[@B2-molecules-18...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Overexpression of somatostatin receptors on the neuroendocrine tumour cell surface is a very well-known phenomenon, but not all neoplasms demonstrate a high incidence of this receptor subtype. Therefore, there is a need to search for other peptide analogues for diagnostic and therapeu...
{ "pile_set_name": "PubMed Central" }
Introduction {#S0001} ============ Over the past 5 years, single-port techniques, such as laparoendoscopic single-site surgery (LESS), have been applied to perform a wide range of operations, both in adults and in children, including cancer resections and live donor nephrectomies \[[@CIT0001]--[@CIT0003]\]. There are...
{ "pile_set_name": "PubMed Central" }
Image in medicine {#S0001} ================= A 64-year-old woman with past medical history of diabetes mellitus type 1, referred to our dermatology department for a 20-month nonpruritic erythematous ulcerated lesions of the two legs. Upon physical examination, a large oval erythematoviolaceous plaque covering more tha...
{ "pile_set_name": "PubMed Central" }
![](brjcancer00004-0022.tif "scanned-page"){.439} ![](brjcancer00004-0023.tif "scanned-page"){.440} ![](brjcancer00004-0024.tif "scanned-page"){.441} ![](brjcancer00004-0025.tif "scanned-page"){.442} ![](brjcancer00004-0026.tif "scanned-page"){.443} ![](brjcancer00004-0027.tif "scanned-page"){.444} ![](brjcancer0...
{ "pile_set_name": "PubMed Central" }
What Is Known About This Topic {#section1-2333393618816780} ============================== - The practice of homecare nursing is changing due to demographic, health, and political developments. - The concrete practice of homecare nursing is under researched, and we have little knowledge of the details of homecare...
{ "pile_set_name": "PubMed Central" }
Related literature {#sec1} ================== For details of the pharmaceutical uses of the closely related compound ambroxol, systematic name 4-(2-amino-3,5-di­bromo­benzyl­amino)cyclo­hexa­nol, see: Felix *et al.* (2008[@bb3]); Gaida *et al.* (2005[@bb4]); Lee *et al.* (2004[@bb5]). For bond length data, see: Allen ...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ The brain is regarded as the master regulator of homeostasis and metabolism. It has been suggested that bone and energy metabolism require tightly coordinated regulation so that longitudinal growth, or bone remodeling, are in accordance with energy supply and demand [@pone.0065505-Karse...
{ "pile_set_name": "PubMed Central" }
Introduction {#S0001} ============ In February 2017, the World Health Organization (WHO) published a list of "critical" resistant bacterial species, including carbapenem-resistant *Pseudomonas aeruginosa, Acinetobacter baumannii*, and *Escherichia coli*. The same document urged the development of new, alternative trea...
{ "pile_set_name": "PubMed Central" }
![](edinbmedj74802-0079){#sp1 .757}
{ "pile_set_name": "PubMed Central" }
Introduction ============ Antidepressant medications such as selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors (SNRIs) are the first-line treatments for patients with moderate to severe major depressive disorder (MDD).[@b1-ndt-14-1261]--[@b3-ndt-14-1261] In 1993, venlafaxine was ...
{ "pile_set_name": "PubMed Central" }
Introduction ============ A well aligned and flexible spine is important for an active and healthy life. Chronic low back pain (CLBP) is defined as back pain lasting more than 12 weeks \[[@B1]\]. This pain is a common musculoskeletal disorder affecting 80% of people some time in their lives \[[@B2]\]. The majority of ...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#s1} ============ Medulloblastoma is the most frequently diagnosed malignant brain tumor in children, with a peak incidence at the age of 5 years \[[@RRU120C1]\]. Despite being rare, it can also be found in adults, in whom pediatric treatment regimes appear feasible and effective, based upon similar pres...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ The cerebellum is a well-known important subcortical motor structure, ensuring coordination, precision, and accurate timing of movement, and learning motor skills \[[@CR1]--[@CR4]\]. The cerebellar neuronal circuitry, organized elaborately and modularly, receives two major types of af...
{ "pile_set_name": "PubMed Central" }
Introduction {#s0001} ============ Psychosocial ill health in society is growing rapidly. The transition to parenthood is a joyful event for the majority of new mothers and fathers; however, it can include depressive symptoms and parental stress ([@C1]--[@C3]), which can negatively affect themselves, their partner, an...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Breast cancer is a leading cause of morbidity and mortality among female cancer patients worldwide. The disease is categorized according to at least three distinct molecular and clinical subtypes with dramatically different outcome and response to therapeutic agents [@b1],[@b2]. The luminal s...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Ubiquitylation describes the covalent attachment of ubiquitin, a 76 amino acid polypeptide, to proteins which occurs as a multi-step process (reviewed in [@pgen.1002261-Welchman1], [@pgen.1002261-Hicke1]). E1-activating enzymes activate ubiquitin and transfer it to E2-conjugating enzyme...
{ "pile_set_name": "PubMed Central" }
Background ========== As obligate blood-feeding arthropods, ticks feed on terrestrial vertebrates and are one of the most important disease vectors worldwide. Ticks are involved in carrying and transmitting a diverse group of pathogenic bacteria, which exert severely negative impacts on human health, livestock product...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Several parameters of quality have been defined for optimal colonoscopy, such as cecal intubation, adverse event rates, duration of withdrawal, and bowel preparation [@JR059-1] [@JR059-2] [@JR059-3] [@JR059-4] [@BR059-5]. High-quality bowel preparation is noted to be of primary importance for...
{ "pile_set_name": "PubMed Central" }
Introduction ============ One of the main goals of professional soccer clubs and their youth academies is to develop young, talented players into successful professional players ([@B27]). Many clubs and national associations (e.g., Germany, Belgium, Portugal, Netherlands) have created programs for talent identificatio...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ It is well known that medical students, interns, and residents experience higher rates of depression than the general population.^[@R1]^ Mata et al.^[@R2]^ recently conducted a systematic review and meta-analysis and calculated the mean prevalence of depression among residents to be 28.8% (ra...
{ "pile_set_name": "PubMed Central" }
Dobbelstein M, Levine AJ. Mdm2: Open questions. Cancer Sci. 2020;111:2203--2211. 10.1111/cas.14433 1. INTRODUCTION {#cas14433-sec-0001} =============== The Mdm2 oncoprotein and its association with p53 were discovered 30 years ago,[^1^](#cas14433-bib-0001){ref-type="ref"}, [^2^](#cas14433-bib-0002){ref-type="ref"}, [...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== Cigarette and alcohol consumption are major causes of preventable deaths worldwide. Smoking is the cause of approximately six million deaths per year \[[@CR1]\] secondary to the development of different cancers as well as cardiovascular and respiratory diseases \[[@CR2]\]. Alcohol consump...
{ "pile_set_name": "PubMed Central" }
Introduction ============ This paper describes a set of fundamental concepts from causality theory that can be used to critically analyze summary measures of population health. It then uses these concepts to argue that health measures based on hypothetical outcome removal \[[@B1],[@B2]\] are ambiguous and potentially ...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== Constrictive Pericarditis (CP) is a potentially curable cause of diastolic heart failure. Known and common etiologies include previous heart surgery, chest radiation, trauma and infections such as tuberculosis. Conversely, a proportion of the cases may not have well identifiable causes, t...
{ "pile_set_name": "PubMed Central" }
Introduction: Human Hepatocellular Carcinoma {#s1} ============================================ Human hepatocellular carcinoma (HCC) is one of the most frequent and pernicious solid tumors, ranking fifth in incidence and second in lethality worldwide ([@B1]--[@B3]). Albeit the prevalence of HCC is highest in Eastern A...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Streptococcus agalactiae, commonly referred as group B streptococcus (GBS), has been recognized as an emerging infection in nonpregnant adults with underlying medical conditions (mainly malignancy and diabetes mellitus).^[@R4],[@R9],[@R10],[@R17],[@R20],[@R23],[@R24],[@R32],[@R33],[@R37]^ Sev...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Resistance training (RT) is a safe and effective way to improve proxies of physical performance in healthy children and adolescents when appropriately prescribed and supervised.[@R1] Several meta-analyses have shown that RT has the potential to improve muscle strength and motor skills (...
{ "pile_set_name": "PubMed Central" }
Data may be made available upon request as we have not received approval from the Ethics Review Committee, Faculty of Medicine, University of Ruhuna, Sri Lanka, to provide the raw data (legal and ethical reasons), that is the pharmacist survey data, to journals for publication. Therefore, we are unable to release this ...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== *Avena nuda* L., also named naked oats, is originated and widely separated in north and high altitude region in China. It belongs to herb of gramineous plant with annual growing. Naked oats has great value in nutrition and medicine. It contains abundant proteins with 18 kinds of...
{ "pile_set_name": "PubMed Central" }
The authors confirm that, for approved reasons, some access restrictions apply to the data underlying the findings. Data contains identifying information and is available upon request from the authors. Introduction {#s1} ============ In India, chronic conditions are a leading cause of death and disabilities and estim...
{ "pile_set_name": "PubMed Central" }
**ATTENTION** The spread of Covid-19 has had a major effect on the 2020 event schedule. Many events have been postponed, rescheduled or cancelled. Readers are advised to check the websites of individual events for the latest information. 31 August--2 September 2020 Shanghai, China **Aquatech China 2020 -- NEW DATE*...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-molecules-20-19798} =============== The development of renewable energy technologies is pivotal for accommodating the ever increasing energy demands of the modern society. Such technologies are also important for lowering environmental pollution and greenhouse gas emissions. Towards this objecti...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Pancreatic carcinoma is one of the most frequently occurring gastrointestinal malignancies and the incidence rate has shown an upward trend worldwide ([@b1-etm-05-01-0155]). The prognosis for patients with advanced pancreatic carcinoma remains poor with a 5-year survival rate of \<5% ([@b1-et...
{ "pile_set_name": "PubMed Central" }
![](menthealthlond70522-0004){#sp1 .2} ![](menthealthlond70522-0005){#sp2 .3}
{ "pile_set_name": "PubMed Central" }
All data are contained within the paper. Introduction {#sec005} ============ Stroke is a major cause of disability in adults \[[@pone.0149757.ref001]\]. It frequently results in hemiparesis (partial paralysis of one side of the body) which causes slow gait with kinematic anomalies \[[@pone.0149757.ref002]\],\[[@pone....
{ "pile_set_name": "PubMed Central" }
Introduction ============ Grain legumes and pulses in countries such as India, Thailand, Bangladesh, Sri Lanka, and Pakistan are characteristically affected by yellow mosaic disease (YMD) caused by *Mungbean yellow mosaic virus* (MYMV), *Mungbean yellow mosaic India virus* (MYMIV), *Dolichos yellow mosaic virus* and *...
{ "pile_set_name": "PubMed Central" }
Published: February 9, 2017 Results and Discussion {#sec1} ====================== Pharyngeal gills are a defining feature of vertebrate animals and are present as vestiges in our own embryology. However, it has been proposed that the gills of cyclostomes and gnathostomes evolved independently. This "ecto-endobranchia...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Adverse birth outcomes such as low birth weight, preterm birth and low Apgar scores are important predictors of infant survival and of long term health, including neurodevelopmental, emotional, and cognitive functioning and educational outcome \[[@B1]-[@B3]\]. Adverse birth outcomes ha...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== Uterine leiomyomas are benign tumors which affect up to 80% of females in their lifetime \[[@B1]\]. Family history, nulliparity, obesity, and race have been established as risk factors for development of uterine leiomyoma \[[@B2], [@B3]\]. They are more prevalent in women of Afr...
{ "pile_set_name": "PubMed Central" }
Protocol background {#sec1} =================== Proteins are often chemically modified by covalent conjugation to investigate the conformational dynamics, molecular interactions and enzyme kinetics in order to gain insight into their biological functions \[[@B1],[@B2]\]. Many single-molecule *in vitro* biochemical and...
{ "pile_set_name": "PubMed Central" }
Introduction {#sec1} ============ Biliary atresia (BA) is the most common cause of endstage liver disease in infants with poor prognosis and high mortality.[@bib1], [@bib2] The incidence of BA in Europe and the United States is about 1:15,000--19,000 live births, whereas the Asian incidence is much higher, ranging fro...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Cervical cancer is a virus-induced disease that is caused by the integration of a human papilloma virus (HPV) DNA into the host\'s genome.[@B1]-[@B3] Infection with HPV causes disruption of the host\'s E2 gene, resulting in expression of viral oncogenes, E6 and E7. The E6 and E7 products inhi...
{ "pile_set_name": "PubMed Central" }
Plain Language Summary {#S0001} ====================== Screening for cervical cancer combined with vaccination against HPV infection, which is the main cause of cervical cancer, has the potential to eliminate cervical cancer in the future. However, only women accepting both vaccination and screening will gain full pro...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== Multiple Sclerosis (MS) is a chronic autoimmune disease of the Central Nervous System (CNS) causing inflammation and neurodegeneration. The characteristic demyelination of the neurons, followed in many cases by axonal loss and gliosis, results in incapacity progression \[[@B1]\]...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== Headache disorders, including migraine, are extremely common \[[@CR1]\]. From a public-health perspective, they are also among the most disabling at population level: according to the Global Burden of Disease (GBD) study, headache disorders collectively are the third highest cause in the ...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ In large introductory biology classes throughout the United States, multiple-choice (MC) formats typify both formative assessments (e.g., clicker questions, concept inventories) and summative tests (e.g., midterm and final exams; see Wood \[[@B52]\] and Smith *et al.* \[[@B46]\]). While there...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Maize (*Zea mays*), also known as corn, is an important cereal crop grown under varied climatic conditions. China is the second-largest producer of maize after the United States. Maize can be processed into human food, animal feed, and industrial products. It is a high-production crop...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ MRI is considered the gold standard imaging modality for the central nervous system. Although MR images provide high resolution and good sensitivity standard MR sequences still suffer of low specificity especially in the case of brain tumors during or after treatment. Tumor progression,...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== We showed that tracheal intubation with atracurium significantly decreased vocal cord injuries compared with tracheal intubation without muscle relaxants (8% versus 42%) \[[@B1]\]. Tracheal intubation with atracurium at maximum neuromuscular block, however, did not decrease voca...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== NR1I2 (nuclear receptor subfamily 1 group I member 2) was discovered in 1998 and named as PXR (pregnane X receptor) or PAR (the receptor activated by pregnane) based on its activation by endogenous pregnanes 21-carbon steroids. Besides, human PXR is known as SXR (steroid and xen...
{ "pile_set_name": "PubMed Central" }
Acute respiratory infections (ARIs) are the most common infections in humans. ARIs (nonspecific upper respiratory infections, otitis media, sinusitis, pharyngitis, bronchitis, and pneumonia) account for half of acute conditions each year [@bib1], and consistently rank among the top 10 reasons for ambulatory visits in t...
{ "pile_set_name": "PubMed Central" }
![](indmedgaz73266-0001){#sp1 .201} ![](indmedgaz73266-0002){#sp2 .202} ![](indmedgaz73266-0003){#sp3 .203} ![](indmedgaz73266-0002-a){#f1 .202} ![](indmedgaz73266-0003-a){#f2 .203}
{ "pile_set_name": "PubMed Central" }
Introduction {#ss1} ============ Prolonged coughing is a frequent symptom in children and is often associated with respiratory tract infection \[[1](#b1){ref-type="ref"}\]. Although prolonged coughing is a prominent feature of infection with *Bordetella pertussis*, infections with other respiratory tract pathogens may...
{ "pile_set_name": "PubMed Central" }
Xie H., Hu L., Wu F., Chen M., Wu L. (2016). Self‐Templated Synthesis of Ultrathin Nanosheets Constructed TiO~2~ Hollow Spheres with High Electrochemical Properties. Adv. Sci., 3: 1600162. doi: 10.1002/advs.201600162 1. Introduction {#advs194-sec-0010} =============== Hollow hierarchical nanostructures with properly ...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== When an implant is inserted into bone the healing process starts by creating new bone that interlocks with the implant surface, so called osseointegration. It has been found that an implant with a rough surface topography enhances osseointegration and load bearing capacity \[[@CR1], [@CR2...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Parkinson's disease (PD) is the second most common neurodegenerative disease that affects almost 1% of individuals over 60 years of age. First described in 1920,^[@B1]^ the ketogenic diet (KD) comprises fat (80-90%), carbohydrate, and protein and metabolically induces a fasting-like condition...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Stroke remains the leading cause of adult disability worldwide. Recovery following stroke is variable but only a third of patients regain some dexterity in the first 6 months (Kwakkel et al., [@B11]) and the majority of stroke survivors are left with residual motor deficits (Duncan et a...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Psychiatric symptoms, such as anxiety, depression, insomnia, and somatization, are the clinical manifestations of common psychiatric and neurological diseases. Many neurological disorders show these indistinguishable psychological symptoms in the early stages, especially when symptoms s...
{ "pile_set_name": "PubMed Central" }
The authors confirm that all data underlying the findings are fully available without restriction. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium (<http://www.proteomexchange.org>) via the PRIDE partner repository with the dataset identifier PXD000778, DOI:10.6019/PXD001269....
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== There is an ever-growing number of patients requiring aortic valve replacement (AVR) \[[@CR1]\]. The two principal reasons for AVR are aortic regurgitation (AR) and aortic stenosis (AS), the latter being the most common indication. Although the majority of patients is older \[[@CR2]\], yo...
{ "pile_set_name": "PubMed Central" }
Introduction ============ The lack of integration within the public health system is one of the most important problems of dental treatment for patients with special needs. Moreover, the peculiarity of decentralization of Public Health Services in Spain, makes public health patients with special needs coverage, very d...
{ "pile_set_name": "PubMed Central" }
Introduction {#S1} ============ With advancement in minimally invasive surgical interventions, arthroscopic surgery is now one of the most common procedures performed in modern orthopaedics \[[@R1]\]. Unlike open surgery, arthroscopic procedures involve 2-D image projection of a three-dimensional operative field requi...
{ "pile_set_name": "PubMed Central" }
Plain english summary {#Sec1} ===================== The effects of a 14-week DMT intervention on body image and alexithymia were tested in 12 patients with EDs. The DMT group (*n*=7) improved in various aspects of body image after the treatment, while no change occurred in the control group (*n*=5). Both groups contin...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Despite the wide range of currently available strategies for chemotherapeutic treatment, prognosis of many types of cancer remains poor for many patients; therefore, there is a clear need for new therapies that improve outcomes. Some of the most common drawbacks of cancer drugs are related t...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== Skin cancer is the most common cancer in the United States (US). It is estimated that close to 4 million skin cancer diagnoses (including basal cell and squamous cell carcinomas) are made every year \[[@B1]\]. Melanoma (an aggressive form of skin cancer) is diagnosed in more tha...
{ "pile_set_name": "PubMed Central" }
Introduction ============ The quinolone derivative mefloquine is widely used in the treatment and prophylaxis of malaria in travelers to areas with chloroquine-resistant falciparum malaria (Palmer et al., [@B23]). In the Netherlands mefloquine is generally prescribed when traveling for longer than 6 weeks to a malaria...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Ethiopia is a rapidly developing country that is burdened and held back by a high prevalence of communicable disease. Of the so-called 'big three' killer diseases, HIV/AIDs, tuberculosis, and malaria, malaria is the most frequent cause of out-patient presentation and in-patient admissio...
{ "pile_set_name": "PubMed Central" }
The spectrum of pathogenic mutations found in genes related to cancer development can vary depending on the ethnic groups that are being studied. Specific pathogenic mutations associated to particular ethnic groups show a high frequency due to founder effects, or population bottleneck and consequent inbreeding. As a re...
{ "pile_set_name": "PubMed Central" }
An incorrect value for Mosquitoes Natural Mortality rate was given in [Table 1](#tab01){ref-type="table"} of the paper by E. Massad, J. Rocklov and A. Wilder-Smith. \[[@ref1]\] [Table 1](#tab01){ref-type="table"} is republished here with the correct value. Table 1.Model\'s parameters, biological meaning, values and sou...
{ "pile_set_name": "PubMed Central" }
Objectives ========== To compare the accuracy of an integrated fiberoptic monitoring system in measuring blood volume (BV) with standard method using chromium-51-tagged erythrocytes in septic shock. Design ====== Prospective animal laboratory study. Measurement and main results ============================ Twenty ...
{ "pile_set_name": "PubMed Central" }
To the Editor: {#cpt1196-sec-0001} A recent drug--drug interaction (DDI) study reported a 3.89--4.67‐fold increase in exposures of dasabuvir by clopidogrel,[1](#cpt1196-bib-0001){ref-type="ref"} and suggested a discrepancy between observed data and previously published physiologically based pharmacokinetic (PBPK) pr...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-foods-09-00341} =============== Food adulteration is an illegal activity of food production, which may threaten food quality and safety. On one hand, the nutritional value of food is limited because of the reduction of effective components in food. On the other hand, the adulterants may have a d...
{ "pile_set_name": "PubMed Central" }
Introduction {#S0001} ============ Non-small-cell lung cancer (NSCLC) including adenocarcinomas and squamous cell carcinomas, ranks among the top 10 list with high prevalence and mortality worldwide. NSCLC was a highly malignant tumor with severe poor prognosis, distant invasion and migration.[@CIT0001] Although the e...
{ "pile_set_name": "PubMed Central" }
Introduction {#sec1} ============ For the earliest cellular organisms,^[@ref1],[@ref2]^ replication must have occurred through primitive mechanisms without elaborate enzymatic machinery.^[@ref3],[@ref4]^ Template-directed nonenzymatic primer extension^[@ref5]^ is an important experimental model system for the study of...
{ "pile_set_name": "PubMed Central" }