saidutta69/red-pill-drug-discovery-formulation

🔴 RED-PILL

Research Enhanced Dataset for Pharmaceutical Innovation in Learning & Language

The first open instruction-tuning dataset for drug discovery & formulation development.

Built for fine-tuning Heretic-ablated models that won't refuse your pharmaceutical R&D questions.

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⚡ Quick Start

from datasets import load_dataset

# Load the full dataset
ds = load_dataset("saidutta69/red-pill-drug-discovery-formulation", data_files="red-pill-full.jsonl")

# Load gold tier (elite 17 instructions)
ds = load_dataset("saidutta69/red-pill-drug-discovery-formulation", data_files="red-pill-full_gold_tier.jsonl")

# Load top tier (145 grade A+B instructions)
ds = load_dataset("saidutta69/red-pill-drug-discovery-formulation", data_files="red-pill-full_top_tier.jsonl")

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📊 Dataset at a Glance

Split	Instructions	Avg Score	Description
Full	1,047	0.541	Complete dataset across all pillars
Gold Tier 🥇	17	0.757	Elite grade-A instructions
Top Tier 🥈	145	—	Grade A+B instructions

🎯 Quality Distribution

Grade A (≥0.75):  ████░░░░░░░░░░░░░░░░  17 (1.6%)
Grade B (≥0.60):  ████████████░░░░░░░░  128 (12.2%)
Grade C (≥0.45):  ████████████████████  789 (75.3%)
Grade D (≥0.30):  ██░░░░░░░░░░░░░░░░░░  102 (9.7%)
Grade F (<0.30):  ░░░░░░░░░░░░░░░░░░░░  11 (1.1%)

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🧬 The Six Pillars

Pillar	Instructions	Focus
🧪 Drug Discovery	631	Target ID, screening, ADMET, molecular properties
💊 Formulation ⭐	62	Solubility enhancement, dosage forms, excipients, stability
⚗️ Synthesis	16	Retrosynthesis, reaction optimization, process chemistry
📋 Regulatory	109	FDA guidance, clinical trial design, patent analysis
🔗 Integration	4	Cross-pillar reasoning, drug repurposing
📚 Literature	402	Paper analysis, methodology critique, research synthesis

📋 Pillar Details (Click to expand)

🧪 Pillar 1: Drug Discovery & Screening

631 instructions

• Target identification & validation
• Virtual screening workflows
• Molecular property prediction
• ADMET profiling & optimization
• Hit-to-lead optimization
• Structure-activity relationships

Sources: ChEMBL 35, DrugBank, PubChem, Expert Knowledge

💊 Pillar 2: Formulation Development ⭐ Key Differentiator

62 instructions

• Solubility enhancement strategies (ASD, nanosizing, cyclodextrins)
• Dosage form design & selection
• Excipient science & compatibility
• Stability prediction & optimization
• Dissolution modeling & IVIVC
• QbD and Design Space concepts

Sources: FDA Orange Book, FormulationAI, Expert Knowledge

⚗️ Pillar 3: Chemical Synthesis

16 instructions

• Retrosynthetic analysis
• Reaction optimization
• Process chemistry & scale-up
• Crystallization & polymorph control
• Green chemistry principles

Sources: ChEMBL, Process Chemistry Knowledge Base

📋 Pillar 4: Regulatory & Clinical

109 instructions

• FDA guidance interpretation
• Clinical trial design (Phase I-IV)
• Bioequivalence requirements
• Stability testing (ICH Q1A-R2)
• ANDA/NDA filing strategy

Sources: ClinicalTrials.gov, FDA Guidance Documents

🔗 Pillar 5: Cross-cutting Integration

4 instructions

• Drug repurposing scenarios
• Formulation-to-clinic pipelines
• Failure analysis & rescue strategies
• Multi-pillar reasoning exercises

Sources: Integrated Knowledge Base

📚 Pillar 6: Literature Mining

402 instructions

• Paper summary & analysis
• Methodology critique
• Cross-paper synthesis
• Research trend identification
• Computational method assessment

Sources: PubMed (274 papers), arXiv (21 papers)

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📋 Data Format

Each instruction follows the ChatML format with rich metadata:

{
  "messages": [
    {
      "role": "user",
      "content": "I have a BCS Class II compound with solubility 0.5 µg/mL and LogP 4.2..."
    },
    {
      "role": "assistant",
      "content": "## Solubility Enhancement Strategy\n\n### Compound Profile:\n- **Solubility:** 0.5 µg/mL (very poor)\n- **LogP:** 4.2 (lipophilic)\n..."
    }
  ],
  "metadata": {
    "pillar": "formulation",
    "domain": "solubility enhancement",
    "skill_type": "requires-reasoning",
    "source": "formulation_knowledge_base",
    "difficulty": "expert"
  }
}

📊 Metadata Fields

Field	Values	Description
pillar	discovery, formulation, synthesis, regulatory, literature, integration	Primary domain
domain	30+ subdomains	Specific topic area
skill_type	requires-knowledge, requires-calculation, requires-reasoning, requires-decision	Cognitive skill tested
difficulty	basic, intermediate, advanced, expert	Complexity level
source	chembl, pubmed, arxiv, fda_orange_book, formulation_kb, etc.	Data provenance

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🎯 Quality Scoring System

Every instruction is scored across 8 dimensions:

Dimension	Weight	What It Measures
Response Depth	15%	Length, detail, specific numbers, examples
Technical Richness	15%	Domain terminology density, drug names, concentrations
Educational Structure	12%	Headers, lists, bold terms, step-by-step format
Multi-Turn Engagement	12%	Conversation depth, coherence across turns
Practical Applicability	15%	Actionable advice, real-world context, decision-making
Domain Specificity	13%	Pharmaceutical terminology concentration
Reasoning Complexity	8%	Analytical vs. purely factual content
Formulation Depth	10%	Formulation-specific knowledge (key differentiator)

🏆 Grade Scale

Grade	Score	Description
A 🥇	≥0.75	Excellent — deep, structured, technical, actionable
B 🥈	≥0.60	Good — solid content, some structure
C	≥0.45	Average — basic content, limited structure
D	≥0.30	Below average — thin content
F	<0.30	Poor — not useful for fine-tuning

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🔬 Evaluation Benchmarks

The dataset includes 32 evaluation questions across 5 categories:

Category	Questions	Difficulty
Knowledge Recall	5	Intermediate-Advanced
Reasoning	3	Expert
Formulation Design	3	Expert
Decision Making	2	Expert
Molecular Analysis	2	Advanced-Expert
Gold Tier (auto)	17	Expert

Run Evaluation

# Download benchmark
python -c "
from datasets import load_dataset
ds = load_dataset('saidutta69/red-pill-drug-discovery-formulation', data_files='benchmarks/benchmark_suite.json')
ds['train'].to_json('benchmark_suite.json')
"

# Run evaluation (after generating model responses)
python benchmarks/evaluate.py \
    --responses your_model_responses.jsonl \
    --benchmark benchmark_suite.json

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🚀 Recommended Fine-Tuning Setup

Base Model

Any Heretic-ablated model works:

Model	Parameters	License
p-e-w/llama-3-8b-it-heretic	8B	Llama 3
p-e-w/mistral-7b-instruct-v0.3-heretic	7B	Apache 2.0
p-e-w/qwen2-7b-instruct-heretic	7B	Apache 2.0

Training Configuration

from transformers import TrainingArguments
from peft import LoraConfig

# LoRA config (recommended for Heretic models)
lora_config = LoraConfig(
    r=16,
    lora_alpha=32,
    target_modules=["q_proj", "v_proj", "k_proj", "o_proj"],
    lora_dropout=0.05,
    bias="none",
    task_type="CAUSAL_LM",
)

# Training args
training_args = TrainingArguments(
    output_dir="./red-pill-heretic",
    num_train_epochs=3,
    per_device_train_batch_size=4,
    gradient_accumulation_steps=8,
    learning_rate=2e-5,
    weight_decay=0.01,
    warmup_ratio=0.1,
    lr_scheduler_type="cosine",
    fp16=True,
    logging_steps=10,
    save_strategy="epoch",
)

⏱️ Expected Training Time

Dataset	Time (Single GPU)
Gold tier (17 examples)	~5 minutes
Top tier (145 examples)	~30 minutes
Full dataset (1,047 examples)	~3 hours

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📈 Data Sources & Provenance

Source	Records	Access
ChEMBL 35	498 drugs, 1,000 bioactivities	Open API
PubMed	274 papers	Open API
arXiv	21 papers (filtered from 83)	Open API
ClinicalTrials.gov	109 trial records	Open API
FDA Orange Book	Formulation compositions	Open CSV
Formulation Knowledge Base	Expert-generated	Synthetic
Drug Discovery Knowledge Base	Expert-generated	Synthetic

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⚠️ Disclaimer

This dataset is for research purposes only. It should not be used as the sole basis for pharmaceutical decisions. Always consult qualified professionals for drug development activities.

The knowledge contained in this dataset reflects publicly available information and expert opinions. It may not represent the current state of the art in all areas.

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📚 Citation

@dataset{red_pill_2025,
  title={RED-PILL: Research Enhanced Dataset for Pharmaceutical Innovation in Learning and Language},
  author={Saidutta Abhishek Dash},
  year={2025},
  publisher={Hugging Face},
  url={https://huggingface.co/datasets/saidutta69/red-pill-drug-discovery-formulation},
  description={Instruction-tuning dataset for drug discovery and formulation development.}
}

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📄 License

Apache License 2.0

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Built with 🔴 by Saidutta

Fine-tune models that won't refuse your pharmaceutical R&D questions.