messages listlengths 2 10 | metadata dict |
|---|---|
[
{
"role": "user",
"content": "What drugs target Endothelin receptor type B? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Endothelin receptor type B\n\nThe following approved drugs are known to interact with En... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Zone of skin? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Zone of skin\n\nThe following approved drugs are known to interact with Zone of skin:\n\n - **BARBITA... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target D(4) dopamine receptor? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting D(4) dopamine receptor\n\nThe following approved drugs are known to interact with D(4) dopam... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Sigma non-opioid intracellular receptor 1? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Sigma non-opioid intracellular receptor 1\n\nThe following approved drugs... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Phospholipidosis? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Phospholipidosis\n\nThe following approved drugs are known to interact with Phospholipidosis:\n\n ... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Trypanothione reductase? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Trypanothione reductase\n\nThe following approved drugs are known to interact with Trypanot... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Glutathione reductase, mitochondrial? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Glutathione reductase, mitochondrial\n\nThe following approved drugs are known... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Prothrombin? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Prothrombin\n\nThe following approved drugs are known to interact with Prothrombin:\n\n - **MELAGATRAN... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Translocator protein? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Translocator protein\n\nThe following approved drugs are known to interact with Translocator p... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Survival motor neuron protein? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Survival motor neuron protein\n\nThe following approved drugs are known to interact w... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Prelamin-A/C? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Prelamin-A/C\n\nThe following approved drugs are known to interact with Prelamin-A/C:\n\n - **SULFAME... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Pasteurella multocida? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Pasteurella multocida\n\nThe following approved drugs are known to interact with Pasteurella ... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target P388? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting P388\n\nThe following approved drugs are known to interact with P388:\n\n - **AMSACRINE** (ChEMBL: CHEMBL43):... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target L1210? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting L1210\n\nThe following approved drugs are known to interact with L1210:\n\n - **AMSACRINE** (ChEMBL: CHEMBL4... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target DNA topoisomerase II? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting DNA topoisomerase II\n\nThe following approved drugs are known to interact with DNA topoisomer... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Felis catus? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Felis catus\n\nThe following approved drugs are known to interact with Felis catus:\n\n - **ETHACRYNIC... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Chymotrypsin-C? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Chymotrypsin-C\n\nThe following approved drugs are known to interact with Chymotrypsin-C:\n\n - **G... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Cricetinae gen. sp.? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Cricetinae gen. sp.\n\nThe following approved drugs are known to interact with Cricetinae gen. ... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Melatonin receptor type 1B? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Melatonin receptor type 1B\n\nThe following approved drugs are known to interact with Me... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Melatonin receptor? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Melatonin receptor\n\nThe following approved drugs are known to interact with Melatonin receptor... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Melatonin receptor type 1A? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Melatonin receptor type 1A\n\nThe following approved drugs are known to interact with Me... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Serotonin 2 (5-HT2) receptor? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Serotonin 2 (5-HT2) receptor\n\nThe following approved drugs are known to interact wit... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target 5-hydroxytryptamine receptor 2A? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting 5-hydroxytryptamine receptor 2A\n\nThe following approved drugs are known to intera... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Adrenergic receptor alpha-1? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Adrenergic receptor alpha-1\n\nThe following approved drugs are known to interact with ... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Histamine H1 receptor? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Histamine H1 receptor\n\nThe following approved drugs are known to interact with Histamine H1... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target 5-hydroxytryptamine receptor 1B? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting 5-hydroxytryptamine receptor 1B\n\nThe following approved drugs are known to intera... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target D(1A) dopamine receptor? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting D(1A) dopamine receptor\n\nThe following approved drugs are known to interact with D(1A) do... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Adrenergic receptor alpha? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Adrenergic receptor alpha\n\nThe following approved drugs are known to interact with Adre... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Trypanosoma brucei? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Trypanosoma brucei\n\nThe following approved drugs are known to interact with Trypanosoma brucei... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target ATP-binding cassette sub-family C member 2? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting ATP-binding cassette sub-family C member 2\n\nThe following approved dru... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Cellular retinoic acid-binding protein 1? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Cellular retinoic acid-binding protein 1\n\nThe following approved drugs a... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Human immunodeficiency virus 1? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Human immunodeficiency virus 1\n\nThe following approved drugs are known to interact... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target MT4? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting MT4\n\nThe following approved drugs are known to interact with MT4:\n\n - **NEVIRAPINE** (ChEMBL: CHEMBL57): S... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Human immunodeficiency virus type 1 reverse transcriptase? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Human immunodeficiency virus type 1 reverse transcriptase... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target HT-29? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting HT-29\n\nThe following approved drugs are known to interact with HT-29:\n\n - **MITOXANTRONE** (ChEMBL: CHEM... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target B16? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting B16\n\nThe following approved drugs are known to interact with B16:\n\n - **MITOXANTRONE** (ChEMBL: CHEMBL58):... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Human immunodeficiency virus type 1 integrase? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Human immunodeficiency virus type 1 integrase\n\nThe following approv... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Tubulin? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Tubulin\n\nThe following approved drugs are known to interact with Tubulin:\n\n - **PODOFILOX** (ChEMBL: C... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Tetrahymena pyriformis? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Tetrahymena pyriformis\n\nThe following approved drugs are known to interact with Tetrahymen... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target KB? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting KB\n\nThe following approved drugs are known to interact with KB:\n\n - **PODOFILOX** (ChEMBL: CHEMBL61): SMILE... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Mycobacterium avium? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Mycobacterium avium\n\nThe following approved drugs are known to interact with Mycobacterium av... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Vero? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Vero\n\nThe following approved drugs are known to interact with Vero:\n\n - **ISONIAZID** (ChEMBL: CHEMBL64):... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target PBMC? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting PBMC\n\nThe following approved drugs are known to interact with PBMC:\n\n - **THALIDOMIDE** (ChEMBL: CHEMBL46... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target CCRF-CEM? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting CCRF-CEM\n\nThe following approved drugs are known to interact with CCRF-CEM:\n\n - **ADENOSINE** (ChEMBL... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Adenosine receptor A1? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Adenosine receptor A1\n\nThe following approved drugs are known to interact with Adenosine re... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Opioid receptors; mu/kappa/delta? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Opioid receptors; mu/kappa/delta\n\nThe following approved drugs are known to inte... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Mu-type opioid receptor? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Mu-type opioid receptor\n\nThe following approved drugs are known to interact with Mu-type ... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Opioid receptor? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Opioid receptor\n\nThe following approved drugs are known to interact with Opioid receptor:\n\n - ... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "What drugs target Monkey? Compare their molecular structures and discuss their mechanism of action."
},
{
"role": "assistant",
"content": "## Drugs Targeting Monkey\n\nThe following approved drugs are known to interact with Monkey:\n\n - **CODEINE** (ChEMBL: CHEMBL... | {
"pillar": "discovery",
"domain": "drug-target interaction",
"skill_type": "requires-knowledge",
"source": "chembl",
"difficulty": "intermediate"
} |
[
{
"role": "user",
"content": "Given that CHEMBL324340 shows IC50 of 2500.0 nM against Heparanase, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 2500.0 nM against Heparan... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL109600 shows IC50 of 9000.0 nM against Heparanase, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 9000.0 nM against Heparan... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL357278 shows IC50 of 4000.0 nM against Peroxisomal acyl-coenzyme A oxidase 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 ... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL357119 shows IC50 of 17000.0 nM against Peroxisomal acyl-coenzyme A oxidase 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL152968 shows IC50 of 180.0 nM against Peroxisomal acyl-coenzyme A oxidase 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 =... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL152968 shows IC50 of 6000.0 nM against Cytochrome P450 1A2, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 6000.0 nM agains... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL152968 shows IC50 of 37000.0 nM against Cytochrome P450 3A4, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 37000.0 nM agai... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL152968 shows IC50 of 24000.0 nM against Cytochrome P450 2C9, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 24000.0 nM agai... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL268177 shows Ki of 6000.0 nM against Carbonic anhydrase 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 6000.0 nM against C... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL268177 shows Ki of 70.0 nM against Carbonic anhydrase 2, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 70.0 nM against Carbo... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL268177 shows Ki of 285.0 nM against Carbonic anhydrase 9, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 285.0 nM against Car... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL268177 shows Ki of 50.0 nM against Carbonic anhydrase 13, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 50.0 nM against Carb... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL268439 shows Ki of 6.0 nM against Carbonic anhydrase 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 6.0 nM against Carboni... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL268439 shows Ki of 2.0 nM against Carbonic anhydrase 2, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 2.0 nM against Carboni... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL268439 shows Ki of 38.0 nM against Carbonic anhydrase 9, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 38.0 nM against Carbo... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL268439 shows Ki of 2.0 nM against Carbonic anhydrase 13, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 2.0 nM against Carbon... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL54530 shows Ki of 19010.78 nM against DNA topoisomerase 3, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 19010.78 nM against... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL54530 shows Ki of 158124.8 nM against DNA topoisomerase 3, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 158124.8 nM against... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL302907 shows Kd of 25.12 nM against Histamine H2 receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Kd = 25.12 nM against Hi... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL302907 shows Kd of 125892.54 nM against Histamine H1 receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Kd = 125892.54 nM ag... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL302907 shows Kd of 398107.17 nM against Unchecked, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Kd = 398107.17 nM against Unchec... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL302907 shows Kd of 50118.72 nM against Adrenergic receptor beta, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Kd = 50118.72 nM a... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL429345 shows IC50 of 0.009 ug.mL-1 against Enterococcus faecium, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 0.009 ug.mL... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL429345 shows IC50 of 0.056 ug.mL-1 against Lacticaseibacillus casei, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 0.056 u... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL429345 shows IC50 of 0.064 ug.mL-1 against Lacticaseibacillus casei, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 0.064 u... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL415997 shows IC50 of 2.9 ug.mL-1 against Cavia porcellus, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 2.9 ug.mL-1 agains... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL13299 shows Kd of 7.943 nM against Cavia porcellus, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Kd = 7.943 nM against Cavia por... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL13299 shows Kd of 199.53 nM against Cavia porcellus, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Kd = 199.53 nM against Cavia p... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL305153 shows Kd of 37.15 nM against Beta-1 adrenergic receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Kd = 37.15 nM again... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL305153 shows Kd of 16.98 nM against Beta-2 adrenergic receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Kd = 16.98 nM again... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL305153 shows IC50 of 29.4 nM against Beta-1 adrenergic receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 29.4 nM aga... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL305153 shows IC50 of 30.8 nM against Beta-2 adrenergic receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 30.8 nM aga... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL156707 shows IC50 of 1584.89 nM against Malate dehydrogenase, mitochondrial, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 =... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL13228 shows Kd of 0.3981 nM against Cavia porcellus, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Kd = 0.3981 nM against Cavia p... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL13228 shows Kd of 0.7943 nM against Cavia porcellus, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Kd = 0.7943 nM against Cavia p... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL279087 shows IC50 of 120.0 nM against GABA-A receptor; anion channel, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 120.0 ... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL279969 shows IC50 of 1850.0 nM against GABA-A receptor; anion channel, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 1850.... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL20214 shows IC50 of 34.0 nM against GABA-A receptor; anion channel, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 34.0 nM ... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL277617 shows IC50 of 107.0 nM against GABA-A receptor; anion channel, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 107.0 ... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL408689 shows Kd of 5011.87 nM against Rattus norvegicus, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Kd = 5011.87 nM against Ra... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL3350133 shows IC50 of 22.0 nM against Opioid receptors; mu & kappa, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 22.0 nM ... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL3350133 shows Ki of 44.0 nM against Mu-type opioid receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 44.0 nM against M... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL3350133 shows Ki of 590.0 nM against Kappa-type opioid receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 590.0 nM agai... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL3350133 shows Ki of 110.0 nM against Delta-type opioid receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 110.0 nM agai... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL15886 shows IC50 of 100000.0 nM against Acetylcholinesterase, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 100000.0 nM ag... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL15886 shows IC50 of 170000.0 nM against Acetylcholinesterase, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 170000.0 nM ag... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL63484 shows Ki of 1400000.0 nM against Pancreatic elastase, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 1400000.0 nM again... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL294543 shows Ki of 2410000.0 nM against Pancreatic elastase, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 2410000.0 nM agai... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL1202755 shows IC50 of 8000.0 nM against Cavia porcellus, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 8000.0 nM against C... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL1202755 shows IC50 of 1000.0 nM against Thromboxane-A synthase, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 1000.0 nM ag... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL542565 shows IC50 of 870.0 nM against L1210, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 870.0 nM against L1210\n\n### P... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
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