messages listlengths 2 10 | metadata dict |
|---|---|
[
{
"role": "user",
"content": "Given that CHEMBL543512 shows IC50 of 930.0 nM against L1210, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 930.0 nM against L1210\n\n### P... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL23228 shows IC50 of 19.0 nM against D(2) dopamine receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 19.0 nM against ... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL21222 shows IC50 of 10.0 nM against GABA-A receptor; anion channel, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 10.0 nM ... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL21087 shows IC50 of 160.0 nM against GABA-A receptor; anion channel, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 160.0 n... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL296346 shows IC50 of 3800.0 nM against ADMET, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 3800.0 nM against ADMET\n\n###... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL129 shows IC50 of 4.0 nM against ADMET, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 4.0 nM against ADMET\n\n### Potency ... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL129 shows IC50 of 150.0 nM against ADMET, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 150.0 nM against ADMET\n\n### Pote... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL129 shows IC50 of 6.0 nM against ADMET, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 6.0 nM against ADMET\n\n### Potency ... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL303519 shows IC50 of 9800.0 nM against D(2) dopamine receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 9800.0 nM aga... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL303519 shows IC50 of 5600.0 nM against D(3) dopamine receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 5600.0 nM aga... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL303519 shows IC50 of 20.0 nM against D(4) dopamine receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 20.0 nM against... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL48946 shows IC50 of 41.0 nM against Sterol O-acyltransferase 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 41.0 nM agai... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL415967 shows IC50 of 45.0 nM against Endothelin-converting enzyme 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 45.0 nM... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL415967 shows IC50 of 6.9 nM against Neprilysin, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 6.9 nM against Neprilysin\n\... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL50381 shows IC50 of 5500.0 nM against Sterol O-acyltransferase 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 5500.0 nM ... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL431940 shows IC50 of 3.0 nM against Sterol O-acyltransferase 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 3.0 nM again... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL431940 shows IC50 of 450.0 nM against Sterol O-acyltransferase 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 450.0 nM a... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL140442 shows IC50 of 3.4 nM against Peptidyl-prolyl cis-trans isomerase FKBP1A, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC5... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL140442 shows IC50 of 200.0 nM against Unchecked, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 200.0 nM against Unchecked\... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL117716 shows IC50 of 44.4 nM against Coagulation factor X, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 44.4 nM against C... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL117716 shows IC50 of 1270.0 nM against Prothrombin, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 1270.0 nM against Prothr... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL117716 shows IC50 of 1440.0 nM against Plasminogen, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 1440.0 nM against Plasmi... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL117716 shows IC50 of 59.2 nM against Serine protease 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 59.2 nM against Seri... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL345415 shows IC50 of 181.0 nM against Muscarinic acetylcholine receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 181... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL345415 shows IC50 of 1.07 nM against Muscarinic acetylcholine receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 1.07... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL326085 shows IC50 of 21000.0 nM against Oxytocin receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 21000.0 nM agains... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL54768 shows IC50 of 0.01 ug.mL-1 against Lanosterol 14-alpha demethylase, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 0.... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL340006 shows Ki of 46.0 nM against D(1A) dopamine receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 46.0 nM against D(... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL340006 shows Ki of 265.0 nM against D(2) dopamine receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 265.0 nM against D... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL336532 shows Ki of 7.6 nM against D(1A) dopamine receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 7.6 nM against D(1A... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL336532 shows Ki of 1190.0 nM against D(2) dopamine receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 1190.0 nM against... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL296415 shows IC50 of 0.00086 ug.mL-1 against P388, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 0.00086 ug.mL-1 against P... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL9650 shows IC50 of 30.0 ug.mL-1 against Human immunodeficiency virus type 1 protease, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis ... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL273396 shows IC50 of 93.0 ug.mL-1 against Human immunodeficiency virus type 1 protease, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysi... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL297654 shows Kd of 37.15 nM against Angiotensin II receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Kd = 37.15 nM against ... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL300191 shows Kd of 27.54 nM against Angiotensin II receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Kd = 27.54 nM against ... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL79591 shows IC50 of 5300.0 nM against Tubulin, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 5300.0 nM against Tubulin\n\n... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL86971 shows Ki of 0.8 nM against Human immunodeficiency virus type 1 protease, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki =... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL86971 shows IC50 of 10.9 nM against H9, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 10.9 nM against H9\n\n### Potency As... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL312911 shows IC50 of 20.0 nM against H9, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 20.0 nM against H9\n\n### Potency A... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL78855 shows IC50 of 5200.0 nM against Protein farnesyltransferase, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 5200.0 nM... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL21521 shows Kd of 300.0 nM against Neurotensin receptor type 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Kd = 300.0 nM again... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL15928 shows Ki of 72.0 nM against 5-hydroxytryptamine receptor 1A, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 72.0 nM aga... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL15928 shows Ki of 0.7 nM against 5-hydroxytryptamine receptor 1D, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 0.7 nM again... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL15928 shows Ki of 0.14 nM against 5-hydroxytryptamine receptor 1B, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 0.14 nM aga... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL312763 shows IC50 of 340.0 nM against Oryctolagus cuniculus, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 340.0 nM agains... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL169084 shows Ki of 13.0 nM against Stromelysin-1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 13.0 nM against Stromelysin-... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL169084 shows Ki of 13.0 nM against Interstitial collagenase, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 13.0 nM against I... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL1160562 shows Kd of 6000.0 nM against Phosphoglycerate kinase, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Kd = 6000.0 nM again... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL76526 shows IC50 of 630.0 nM against HL-60, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 630.0 nM against HL-60\n\n### Po... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL302455 shows IC50 of 1.0 nM against Disintegrin and metalloproteinase domain-containing protein 17, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content":... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL302455 shows Ki of 435.0 nM against 72 kDa type IV collagenase, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 435.0 nM again... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL302455 shows IC50 of 9100.0 nM against Disintegrin and metalloproteinase domain-containing protein 17, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"conten... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL60373 shows Ki of 482.0 nM against 72 kDa type IV collagenase, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 482.0 nM agains... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL60373 shows IC50 of 2650.0 nM against Disintegrin and metalloproteinase domain-containing protein 17, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL79902 shows IC50 of 4.0 nM against Phosphodiesterase 4, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 4.0 nM against Phosp... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL79902 shows IC50 of 3.981 nM against Phosphodiesterase 4, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 3.981 nM against P... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL421343 shows IC50 of 30.0 nM against Phosphodiesterase 4, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 30.0 nM against Ph... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL421343 shows IC50 of 30.2 nM against Phosphodiesterase 4, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 30.2 nM against Ph... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL82934 shows IC50 of 36.0 nM against Phosphodiesterase 4, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 36.0 nM against Pho... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL82934 shows IC50 of 36.31 nM against Phosphodiesterase 4, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 36.31 nM against P... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL111217 shows Ki of 7.8 nM against Retinoic acid receptor RXR-alpha, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 7.8 nM aga... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL111217 shows Ki of 11.5 nM against Retinoic acid receptor RXR-beta, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 11.5 nM ag... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL111217 shows Ki of 13.2 nM against Retinoic acid receptor RXR-gamma, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 13.2 nM a... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL111217 shows Ki of 8300.0 nM against Retinoic acid receptor alpha, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 8300.0 nM a... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL111217 shows Ki of 5681.0 nM against Retinoic acid receptor beta, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 5681.0 nM ag... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL111217 shows IC50 of 6.8 nM against Retinoic acid receptor RXR-alpha, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 6.8 nM... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL266628 shows Ki of 4.0 nM against Angiotensin II receptor (AT-1) type-1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 4.0 n... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL266628 shows Ki of 5.0 nM against Endothelin-1 receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 5.0 nM against Endoth... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL285848 shows IC50 of 11900.0 nM against Protein farnesyltransferase, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 11900.0... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL342713 shows IC50 of 110.0 nM against Disintegrin and metalloproteinase domain-containing protein 17, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL68920 shows IC50 of 41.0 nM against Epidermal growth factor receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 41.0 n... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL68920 shows IC50 of 16500.0 nM against Vascular endothelial growth factor receptor 2, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis ... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL68920 shows IC50 of 300.0 nM against Epidermal growth factor receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 300.0... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL68920 shows IC50 of 300.0 nM against Receptor tyrosine-protein kinase erbB-2, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 ... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL68920 shows IC50 of 7820.0 nM against Epidermal growth factor receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 7820... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL68920 shows IC50 of 2500.0 nM against Receptor tyrosine-protein kinase erbB-2, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL69960 shows IC50 of 170.0 nM against Epidermal growth factor receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 170.0... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL69960 shows IC50 of 40.0 nM against Epidermal growth factor receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 40.0 n... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL69960 shows IC50 of 400.0 nM against Receptor tyrosine-protein kinase erbB-2, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 ... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL69960 shows IC50 of 440.0 nM against Epidermal growth factor receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 440.0... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL69960 shows IC50 of 1210.0 nM against Receptor tyrosine-protein kinase erbB-2, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL170061 shows Ki of 9.0 nM against Histamine H3 receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 9.0 nM against Histam... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL172437 shows Ki of 90.0 nM against Histamine H3 receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 90.0 nM against Hist... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL27759 shows IC50 of 5400.0 nM against HCT-116, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 5400.0 nM against HCT-116\n\n... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL300266 shows IC50 of 6000.0 nM against Vascular cell adhesion protein 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 600... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL330643 shows IC50 of 734.0 nM against Proteinase-activated receptor 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 734.0... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL369583 shows Ki of 1.3 nM against Coagulation factor X, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 1.3 nM against Coagula... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL369583 shows Ki of 2670.0 nM against Prothrombin, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 2670.0 nM against Prothrombi... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL369583 shows Ki of 18.0 nM against Serine protease 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 18.0 nM against Serine p... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL176744 shows Ki of 2.0 nM against Coagulation factor X, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 2.0 nM against Coagula... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL176744 shows Ki of 870.0 nM against Prothrombin, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 870.0 nM against Prothrombin\... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL176744 shows Ki of 16.0 nM against Serine protease 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 16.0 nM against Serine p... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL367476 shows Ki of 3.3 nM against Coagulation factor X, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 3.3 nM against Coagula... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL367476 shows Ki of 2300.0 nM against Prothrombin, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 2300.0 nM against Prothrombi... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL367476 shows Ki of 13.0 nM against Serine protease 1, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 13.0 nM against Serine p... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL446612 shows IC50 of 227000.0 nM against Glutathionylspermidine synthase, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of IC50 = 22... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL108417 shows Ki of 1062.0 nM against Nociceptin receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 1062.0 nM against No... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL108417 shows Ki of 10620.0 nM against Mu-type opioid receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 10620.0 nM agai... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
[
{
"role": "user",
"content": "Given that CHEMBL108417 shows Ki of 4099.0 nM against Kappa-type opioid receptor, what does this suggest about its potential as a drug candidate? Discuss selectivity and potency considerations."
},
{
"role": "assistant",
"content": "## Analysis of Ki = 4099.0 nM aga... | {
"pillar": "discovery",
"domain": "ADMET",
"skill_type": "requires-reasoning",
"source": "chembl",
"difficulty": "advanced"
} |
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