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pubmedcausal_15804 | Obesity is widespread and linked to various co-morbidities. Bariatric surgery has been identified as the only effective treatment, promoting sustained weight loss and the remission of co-morbidities | [
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pubmedcausal_12080 | In pediatric onset UC, the HLA explains almost the entire genetic associations. In addition, the HLA association is approximately twice as strong in pediatric UC compared with adults, due to a combination of novel and shared effects. We speculate the paramount importance of antigenic stimulation either by infectious or... | [
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pubmedcausal_14406 | The identified master regulator genes of asthma provide a novel path forward to further uncovering asthma mechanisms and therapy | [
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pubmedcausal_26118 | Recent advancements in information technology and wearable devices have revolutionized healthcare through health data analysis. Identifying significant relationships in complex health data enhances healthcare and public health strategies. In health analytics, causal graphs are important for investigating the relationsh... | [
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pubmedcausal_14414 | Controlling unobserved confounding still remains a great challenge in observational studies, and a series of strict assumptions of the existing methods usually may be violated in practice. Therefore, it is urgent to put forward a novel method | [
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pubmedcausal_10731 | There were few radiation oncology significant adverse events, but analysis has led to the identification of several specific opportunities for improvement in pediatric anesthesia for radiation oncology | [
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pubmedcausal_26393 | In summary, a higher zinc concentration is causally associated with a reduced depression risk. This MR outcome may assist clinicians in the regulation of specific mineral intake, particularly for high-risk patients with serum zinc deficiencies | [
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pubmedcausal_27037 | Observational analyses showed a robust association of VAT mass with the risk of gout. Meanwhile, MR analyses also provided evidence of a causal relationship between them. In summary, our findings suggested that targeted interventions for VAT mass may be beneficial to prevent gout | [
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pubmedcausal_28398 | This study points to a potentially increased risk of skin cancer, bladder cancer, and endocrine-mediated tumors in Rhineland-Palatinate winegrowing communities. However, due to the explorative ecologic study design and the problem of multiple testing, these findings are not conclusve for a causal relationship | [
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pubmedcausal_14790 | The popularity of dengue can be inferred from Google Trends that summarizes Google searches of related topics. Both the disease and its Google Trends have a similar source of causation in the dengue virus, leading us to hypothesize that dengue incidence and Google Trends results have a long-run equilibrium | [
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pubmedcausal_25009 | Road traffic injuries stands as a major concern globally, as they result in significant loss of life, economic impact, and erode trust in government and societal safety. The influence of weather on road traffic safety is undeniable, impacting road conditions, individuals, and vehicles. However, the specific influence o... | [
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pubmedcausal_27190 | This study provides MR evidence supporting causal association of thyrotoxicosis with knee OA in European population, whereas OA may have no causal effects on thyrotoxicosis | [
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pubmedcausal_1655 | Optic neuritis is an acute, demyelinating neuropathy of the optic nerve often representing the first appreciable symptom of multiple sclerosis. Wallerian degeneration of irreversibly damaged optic nerve axons leads to death of retinal ganglion cells, which is the cause of permanent visual impairment. Although the speci... | [
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pubmedcausal_5161 | Through genetic analyses, our study has unveiled profound causal connections between specific types of immune cells and PVFS, offering valuable guidance for forthcoming clinical investigations | [
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pubmedcausal_5193 | This MR study supported a causal effect of ECG parameters, including ST duration and QRS duration, on BrS development | [
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pubmedcausal_5098 | This study supports the causal relationship between OA and specific circulating inflammatory proteins and develops potential OA-related inflammatory biomarkers | [
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pubmedcausal_10262 | While occupational exposure to respirable silica is known to lead to lung disease, most notably silicosis, its association with chronic kidney disease is unclear | [
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pubmedcausal_17375 | Long-term higher exposure to retinol metabolite is causally associated with longevity in the general population. Future MR analyses could assess the current findings further by utilizing additional genetic variants and greater samples from large-scale GWASs | [
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pubmedcausal_13164 | RHF is a complex syndrome including diverse causes, pathways, and pathological processes. In this scientific statement, we review the causes and epidemiology of RV dysfunction and the pathophysiology of acute and chronic RHF and provide guidance for the management of the associated conditions leading to and caused by R... | [
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pubmedcausal_5442 | In conclusion, this study establishes a causal connection between gut microbiota and hypertension, along with common associated complications. The findings unveil potential targets and evidence for future hypertension and complication treatment through gut microbiota interventions, offering a novel avenue for therapeut... | [
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pubmedcausal_24681 | This study provides evidence for a causal relationship between stroke and FI and offers new insights into the genetic study of FI | [
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pubmedcausal_20453 | This data-driven MR analysis revealed that gut microbiota was causally associated with lung diseases, providing genetic evidence for further mechanistic and clinical studies to understand the crosstalk between gut microbiota and lung diseases | [
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pubmedcausal_24974 | Depression is a susceptibility factor for non-alcoholic fatty liver disease, and the causal effect of genetic susceptibility to depression on non-alcoholic fatty liver disease is mediated by waist-hip ratio, hypertension, and daytime nap | [
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pubmedcausal_24611 | Our finding has revealed the underlying mechanism by which increased selenium level lead to deterioration of renal function, effectively guiding the prevention of chronic kidney disease and paving the way for future studies | [
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pubmedcausal_51 | Repeat hepatectomy and prolonged surgery were identified as risk factors for bile leakage after liver resection for HCC. Bile leakage and repeat hepatectomy increased the risk of organ/space SSI | [
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pubmedcausal_13524 | Interoceptive dysfunction is emerging as an important biomarker for mental illnesses, such as depression which is a leading cause of disability and death worldwide. Little empirical research explains the relationship between interoception and depression | [
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pubmedcausal_17042 | This was the first study in a busy community setting that examined ED visits over a short postpartum period. Patient education on pain management and wound care can reduce the rate of early postpartum ED visits | [
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pubmedcausal_28194 | The national morbidity and mortality associated with falls from a height is incompletely described. The authors estimated the rates of injury, hospitalization, and mortality due to these falls for subgroups of the U.S. population | [
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pubmedcausal_2371 | One third of the variance in liability of PTSD symptoms is due to familial factors, and of this, approximately one fifth overlaps with the familial liability for trauma exposure while the other four fifths of the variance is specific to the risk of PTSD symptoms following exposure. The hypothesis that PTSD is etiologic... | [
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pubmedcausal_4821 | Adolescence is a critical development transition period that increases vulnerability to poor mental health outcomes. Recent evidence suggests that adolescents in Uganda experience high rates of behavioral and emotional disorders. We examined the factors associated with emotional and behavioral health outcomes among sch... | [
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pubmedcausal_24805 | Compared with sham stimulation, multitarget and two single-target tDCS over the rDLPFC or rMT improved posttest performance and accelerated learning during the early period. However, multitarget tDCS and two single-target tDCS led to equivalent benefits for VPL. Additionally, these beneficial effects were absent when a... | [
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pubmedcausal_6523 | Glaucoma is the leading cause of irreversible blindness. However, the current available treatment methods are still unsatisfactory. Therefore, the exploration of new drug targets for the treatment of glaucoma is of paramount importance | [
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pubmedcausal_23167 | SAT, but not VAT, increased the risk of AKI among abdominal trauma patients. Measurement of SAT might help identify patients at higher risk of AKI | [
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pubmedcausal_15313 | Through a screening approach, we identified a deep intronic variant causal for FH. This finding indicates that filtering intronic variants in FH- patients for the absence in FH + patients might enrich for true FH-causing variants and suggests that intronic regions of LDLR need to be considered for sequencing in FH- pat... | [
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pubmedcausal_152 | Vaginal douching is a prevalent practice in Egypt and has traditional and religious roots within the community. There are many misbeliefs around this habit in Egypt. Vaginal douching increases certain reproductive health hazards especially preterm labor and PID. Much effort and awareness campaigns are needed to increas... | [
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pubmedcausal_26695 | Previous observational studies have established the high prevalence of bacterial pneumonia in diabetic patients, which in turn leads to increased mortality. However, the presence of a causal connection between bacterial pneumonia and diabetes remains unobserved | [
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pubmedcausal_29182 | Our findings provide evidence that exposure to POPs commonly present in food chains leads to insulin resistance and associated metabolic disorders | [
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pubmedcausal_27122 | Cheese intake is causally negatively correlated with the occurrence of DR, and cheese intake could reduce the risk of DR | [
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pubmedcausal_22343 | PDC, DHC, and QDC are the main constitution types of patients with HUA, while PDC and QDC may be the risk factors for HUA. DHC, PDC, and BSC are the main constitution types of patients with gout, and they may be the risk factors for gout. In clinical and scientific research, more attention should be paid to the relatio... | [
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pubmedcausal_20674 | Through MR analysis, we established a causal link between Actinobacteria and the incidence of IgAN. Moreover, clinical validation using fecal samples indicated that Actinobacteria might be associated with the onset and poorer prognosis of IgAN. This finding could provide valuable biomarkers for early, noninvasive detec... | [
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pubmedcausal_25736 | We demonstrated a causal relationship between TSAT and LV remodeling and function in a preserved ejection fraction population | [
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pubmedcausal_5957 | Both observational meta-analysis and MR analysis based on genetic variation provide robust evidence indicat that folate supplementation decreases the risk of melanoma, suggesting that interventions targeting folate supplementation may contribute to the primary prevention of melanoma. Further studies are needed to explo... | [
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pubmedcausal_17406 | Due to use of cross-sectional self-report data, the present findings could not establish causality between variables, and provide probable, rather than clinical, diagnoses | [
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pubmedcausal_20276 | In this MR study, we demonstrated a causal relationship between blood metabolites and the risk of developing sepsis, pneumonia, and UTI. However, there was no evidence of a causal connection between blood metabolites and the risk of URTI or SSTI, indicating a need for larger-scale studies to further investigate suscept... | [
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pubmedcausal_27758 | This study offers the initial evidence of a genetic causal link between cathepsins and BPDs. Our findings revealed that cathepsin O was beneficial in preventing BPH, whereas cathepsin X posed a potential threat to prostatitis. Additionally, prostatitis negatively affected cathepsin V level. These three cathepsins could... | [
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pubmedcausal_22536 | Basic medical insurance has a significant health effect, that is, basic medical insurance has a significant positive impact on individual self-rated health. Participating in basic medical insurance can significantly improve the ability of families to face risk shocks, promote the accumulation of health capital in famil... | [
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pubmedcausal_6272 | The RI-CLPM analyses revealed that neuroticism and problematic gaming significantly predict each other. Extraversion acts as a protective factor against adolescent problematic gaming, whereas problematic gaming leads to a decrease in extraversion levels. Additionally, the longitudinal relations between neuroticism and ... | [
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pubmedcausal_19209 | The dementias are long-term, chronic conditions caused by progressive neurological degeneration. Current literature suggests that cardiovascular disease risk factors may contribute to the onset of dementia; however, evidence of these associations is inconsistent | [
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pubmedcausal_14510 | The findings provide support for a causal role of negative self-imagery in adolescent social anxiety and point to the potential clinical value of techniques targeting imagery to treat the disorder | [
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pubmedcausal_19997 | DILI was the predominant cause of severe liver damage, followed by hepatitis virus co-infection. For patients with alcohol consumption and thrombocytopenia, frequent monitoring of liver function tests should be considered | [
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pubmedcausal_17151 | Our study strongly suggests that, within the time frame of just a single year, Timothy's Law significantly increased inpatient mental healthcare utilization in NY. Our study raises the possibility that similar laws in other locations could have similar effects | [
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pubmedcausal_5573 | This review highlights a causal association between DM and TB, emphasizing the need for integrated screening and management of DM within TB control programs, particularly in high-burden regions. Future MR studies should include diverse populations to enhance generalizability and explore genetic mechanisms underlying th... | [
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pubmedcausal_11173 | The influence of the Warburg phenomenon on chemotherapy response is unknown. Saccharomyces cerevisiae mimics the Warburg effect, repressing respiration in the presence of adequate glucose. Yeast phenomic experiments were conducted to assess potential influences of Warburg metabolism on gene-drug interaction underlying ... | [
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pubmedcausal_9941 | Greater arterial stiffness is associated with more depressive symptoms; this association is partly accounted for by white matter hyperintensity volume and subcortical infarcts. This study supports the hypothesis that arterial stiffness leads to depression in part via cerebral small vessel disease | [
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pubmedcausal_17155 | Exotic snakebite is a rare occurrence in Switzerland but has led to medically relevant morbidity, sometimes requiring antivenom treatment. Over half of the envenomed patients required symptomatic or specific treatment. No fatalities or bites in children were reported | [
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pubmedcausal_17952 | Heart transplant volume is no longer skewed toward patients with private insurance, suggesting expanding public insurance increased access to heart transplantation, according to the Organ Procurement and Transplantation Network database. Through a national DiD model, ME increased heart transplant volume for Medicaid be... | [
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pubmedcausal_16508 | Access to electricity, female education rate, public health expenditure, economic growth, and immunization rate, all have a positive effect on female life expectancy at birth, and a negative effect on the female adult mortality rate. The urbanization rate has a significantly positive impact on female life expectancy at... | [
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pubmedcausal_21033 | The findings of this research found evidence of a causal relationship between MD and ED. However, we did not find a causal relationship between BD and ED in European populations | [
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pubmedcausal_28040 | The treatment of burns remains a challenge due to the associated high morbidity and mortality. Besides the administration of physiologic saline, local disinfection, and symptomatic medications, no causal therapy is known to reduce the tissue damage and accelerate wound healing. The aim of the study was to develop a rel... | [
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pubmedcausal_2970 | Increased oscillatory responses in EDS may reflect a need for greater cognitive resources due to disrupted communication in fronto-temporo-limbic circuits encoding conflict. Our results highlight a role of these circuits in conflict encoding and can inform interventions for improving cognitive control in these populati... | [
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pubmedcausal_26916 | Peripheral arteriosclerosis is caused by any atherosclerosis outside the heart and brain. However, the underlying biological mechanisms are not fully understood. This study aims to explore the causal relationship between blood metabolites and peripheral arteriosclerosis | [
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pubmedcausal_7266 | Road traffic injuries are among the leading causes of death in the world and Iran | [
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pubmedcausal_16882 | Our findings highlight the importance for healthcare providers in Switzerland to pay special attention to possible drug-induced liver injuries because of their high mortality rate. The analysis of real-world data confirms the previous assumption that hepatitis is the most frequent hepatic adverse event for checkpoint i... | [
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pubmedcausal_10402 | Either MMU or self-medication with marijuana was common, mainly due to pain management. Additional research is needed to evaluate temporal and causal associations of non-medical marijuana use with MMU | [
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pubmedcausal_18475 | Deletion carriers exhibited decreased theta- and gamma-band responses to visual stimuli, while alpha/beta desynchronization was preserved. Overall, the lack of age-related changes in deletion carriers implicates developmental impairments in circuit mechanisms underlying neural oscillations. The dissociation between the... | [
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pubmedcausal_3344 | This study provides novel evidence that supports the causal association between PC species and frailty, with the immune system playing a crucial role in this pathway. These findings offer new insights into potential targets for the intervention of frailty in the elderly population | [
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pubmedcausal_11770 | Tobacco and overweight/obesity remain the top contributors of attributable cancer cases. Tobacco smoking has the highest PAF because it greatly increases cancer risk and has a large number of cancer types associated with it. Overweight/obesity has the second-highest PAF because it affects a high proportion of the UK po... | [
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pubmedcausal_5774 | The number of hospital visits, per capita health expenditures, and per capita GDP all positively contribute to the development of the pharmacist workforce. Per capita health expenditures lead to an increase in the number of pharmacists in the short term. Among the selected indicators, the primary drivers of pharmacist ... | [
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pubmedcausal_454 | On placebo, there was no learning either within training sessions or between days, except for a fast, rapidly saturating, improvement early on each testing day. However, testosterone caused "off-line" learning, with no learning seen within training sessions, but a marked performance improvement over the days between se... | [
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pubmedcausal_14916 | Observational and genetic analyses demonstrate a concordant, positive and potentially causal relationship of lymphocyte count with systolic BP and diastolic BP | [
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pubmedcausal_26790 | Both plasma lipidome and circulating inflammatory proteins demonstrate a causal relationship with PD. Additionally, circulating inflammatory proteins may serve as mediators in the pathway from plasma lipidome to PD. These findings may contribute to the prediction and diagnosis of PD and potentially pave the way for tar... | [
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pubmedcausal_27506 | This study establishes a causal link between immune cell phenotype and the pathogenesis of PD, identifying several specific immune cell characteristics associated with PD. This could inspire researchers to delve into the pathogenesis of PD at the cellular subtype level, and aid in the identification of potential pharma... | [
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pubmedcausal_23575 | ANA positivity is strongly correlated with thyroid autoimmunity. Further study is warranted to clarify the causal relationship between thyroid autoimmunity and ANA in pregnant women.This research is essential to evaluate and predict the risk of co-existing autoimmune disorders,leading to improved care for pregnancy and... | [
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pubmedcausal_14443 | Several studies have argued a causal relationship between diabetes and depression, while others have highlighted that their association is a result of common risk factors. Because Mexico is a country with a high prevalence of diabetes, and diabetes and depression are a frequent comorbidity, we chose this country to inv... | [
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pubmedcausal_468 | People often face decisions that pit self-interested behavior aimed at maximizing personal reward against normative behavior such as acting cooperatively, which benefits others. The threat of social sanctions for defying the fairness norm prevents people from behaving overly selfish. Thus, normative behavior is influen... | [
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pubmedcausal_15248 | Obesity is one of the leading preventable causes of cancer that has a causal relationship with cancers of esophagus, breast and colon. Paradoxically, there are studies demonstrating that obesity is associated with improved survival in cancer patients. The aim of our study was to investigate the association of obesity a... | [
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pubmedcausal_23072 | Myopia is a common eye disorder that results from gene-environment interactions. The prevalence of myopia varies across populations, and exposure to bright sunlight may prevent its development. We hypothesize that local adaptation to light environments during human migration played a role in shaping the genetic basis o... | [
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pubmedcausal_25135 | This study revealed a causal relationship between lipid metabolites and ADs, providing novel insights into the mechanism of AD development mediated by serum metabolites and possible biomarkers for early diagnosis | [
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pubmedcausal_15564 | Variables in which a causality was found with type A or B virus were: admission to the PICU, month of diagnosis, and cough. However, influenza B clinical behavior continues to be unpredictable | [
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pubmedcausal_26867 | Our study establishes a causal association between higher genetically determined levels of serum indirect bilirubin and reduced risk of ischemic stroke in an Asian population. Future research should include more in-depth analysis of shared genetic variants between indirect bilirubin and ischemic stroke | [
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pubmedcausal_9982 | Cytisine increases the chances of quitting, although absolute quit rates were modest in two recent trials. Varenicline at standard dose increased the chances of successful long-term smoking cessation between two- and three-fold compared with pharmacologically unassisted quit attempts. Lower dose regimens also conferred... | [
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pubmedcausal_12678 | In this first MR study of BMI and back pain, we found a significant causal effect of BMI on both back pain and chronic back pain. These slides can be retrieved under Electronic Supplementary Material | [
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pubmedcausal_20498 | Our MR study provides evidence for a causal relationship between focal epilepsy-documented HS and AD | [
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pubmedcausal_19734 | Altogether, our genetic findings indicate that mtDNA-CN is a complex biomarker reflecting specific MT processes related to mtDNA regulation, and that these processes are causally related to human diseases | [
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pubmedcausal_8194 | Measurements in the neurosciences are afflicted with observational noise. Granger-causality inference typically does not take this effect into account. We demonstrate that this leads to false positives conclusions and spurious causalities | [
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pubmedcausal_24654 | This study reveals a causal relationship between specific microorganisms and periodontitis in the Asian population, shedding light on the influence of gut microbiota on periodontitis | [
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pubmedcausal_27259 | This study provides compelling evidence of the gut microbiota's nominal causal influence on rosacea, shedding light on the gut-skin axis's intricacies and offering potential avenues for therapeutic interventions in rosacea management. Further research is warranted to validate these findings and explore their clinical i... | [
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pubmedcausal_18142 | These results provide evidence for a BMI-independent causal effect of eBMD on OA. Despite evidence of bidirectional effects, the effect of BMD on OA did not appear to be fully explained by shared genetic aetiology, suggesting a direct action of bone on joint deterioration | [
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pubmedcausal_19274 | Evidence supports a causal relationship between circadian disturbance and impaired glucose homeostasis | [
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pubmedcausal_5948 | Psychological stress, particularly financial difficulties, can increase the risk of ED, while the absence of such stressors appears to be protective. Consequently, it is imperative to enhance medical education and awareness among economically disadvantaged populations and to address the detrimental effects of adverse l... | [
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pubmedcausal_13565 | In conclusion, the present study provides further evidence of a causal association between PFAS and serum lipids, especially for PFHxS | [
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91,
95
],
[
100,
112
]
] |
pubmedcausal_26123 | We present the first elucidation of the causal influence of microbiota and metabolites on DLBCL using MR methods, providing novel insights for potential targeting of specific microbiota or metabolites to prevent, assist in diagnosis, and treat DLBCL | [
[
60,
70
],
[
90,
95
],
[
75,
86
]
] |
pubmedcausal_21131 | Six species of apicomplexan parasites of the genus Babesia, namely B. microti, B. divergens, B. duncani, B. motasi, B. crassa-like and B. venatorum, are considered to be the primary causal agents of human babesiosis in endemic areas. These six species possess variable degrees of virulence for their primary hosts. There... | [
[
67,
77
],
[
199,
232
],
[
330,
437
],
[
79,
91
],
[
93,
103
],
[
105,
114
],
[
116,
130
],
[
135,
147
]
] |
pubmedcausal_17919 | Our findings suggest a causal role of cytokines in the pathogenesis of Alzheimer's disease and fluid intelligence | [
[
38,
47
],
[
95,
113
],
[
55,
90
]
] |
pubmedcausal_21542 | Most antihypertensives can induce dermal photosensitivity, which may increase melanoma risk. However, corroborating evidence is limited. We examined the associations between use of antihypertensives and melanoma risk | [
[
0,
22
],
[
27,
57
]
] |
pubmedcausal_4806 | Overweight and obesity greatly increase the risk of preeclampsia. There is a need to better risk-stratify these women in pregnancy and channel resources to those who can benefit most | [
[
0,
10
]
] |
pubmedcausal_29191 | Each approach faces different challenges with respect to the likely sources of confounding and the ability to control for that confounding because of differences in the type, availability, and quality of information required. Thoughtful consideration of these differences should help investigators select the analytic ap... | [
[
150,
173
],
[
0,
90
]
] |
pubmedcausal_23752 | Granular inspection of identity dimensions was infeasible due to sample size and causal inferences cannot be drawn given cross-sectional nature of the data used | [
[
65,
76
],
[
0,
57
]
] |
pubmedcausal_27187 | By combining GWAS and transcriptome data, this study demonstrated the causal role of CRD behavior in AD, identified the potential target genes in shift work-induced AD, and generated CDL to characterize CRD status, which provided evidence and prospects for disease prevention and future therapeutic interventions | [
[
85,
97
],
[
101,
103
]
] |
pubmedcausal_28495 | Aviation accidents have been reduced substantially by training pilots to avoid high-risk behaviors caused by cognitive errors. To determine whether similar cognitive cause factors or errors are involved in medical malpractice cases, and to evaluate the reliability of identifying such factors, physicians reviewed state ... | [
[
54,
98
],
[
0,
50
],
[
109,
125
],
[
79,
98
]
] |
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