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pubmedcausal_28923 | The Northridge earthquake was a significant trigger of sudden death due to cardiac causes, independently of physical exertion. This finding, along with the unusually low incidence of such deaths in the week after the earthquake, suggests that emotional stress may precipitate cardiac events in people who are predisposed... | [
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pubmedcausal_23142 | This analysis demonstrates a possible bidirectional causal connection between the prevalence of particular gut microbiota and the occurrence of influenza infection. The presence of certain gut microbiota may potentially contribute to the development of pneumonia caused by influenza. Additional investigation into the in... | [
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pubmedcausal_12405 | Longitudinal studies have suggested a causal relationship between disability acquisition and mental health, but there is substantial heterogeneity in the magnitude of the effect. Previous studies have provided evidence that socioeconomic characteristics can buffer the effect but have not examined the role of employment... | [
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pubmedcausal_26750 | The findings of this Mendelian randomization assessment provide substantiation for a reciprocal causative association between migraine and VTE within the European population | [
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pubmedcausal_11351 | Psychological practitioners often seek to directly change the form or frequency of clients' maladaptive perfectionist thoughts, because such thoughts predict future depression. Indirect strategies, such as self-compassion interventions, that seek to change clients' relationships to difficult thoughts, rather than tryin... | [
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pubmedcausal_2927 | The paper confirms that Internet use significantly reduces depression, with social interaction and social support playing a mediating role. The results of the study show that strengthening rural Internet infrastructure can promote healthy aging in rural areas | [
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pubmedcausal_16310 | Our findings suggest a causal role of HDL-C, TG, and IGF-I in breast cancer. Observational and MR analyses support an interplay between IGF-I and TG; however, MVMR estimates suggest that TG and IGF-I may act independently to influence breast cancer | [
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pubmedcausal_5678 | The findings demonstrate a positive, causal association between TMD risk and AS, RA, and osteoporosis. Moreover, TMD patients exhibit an increased risk of developing RA | [
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pubmedcausal_13283 | Environmental health indicators determination based on the causal effect model leads to a better understanding of the relationship between the environment and health by simplifying data in an understandable format for public and improves prioritization of policy-making in the environmental health. In this study, enviro... | [
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pubmedcausal_16525 | We define a particular form of bias, collider bias, that is a likely explanation for why studies have found a supposedly protective association of PTSD with suicide. This protective association is interpreted by some researchers as evidence that PTSD reduces the risk of suicide. Collider bias may occur through inapprop... | [
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pubmedcausal_10750 | As compared to sham stimulation, left DLPFC anodal tDCS resulted in increased PD when confronted with negative emotional images, whereas right DLPFC anodal tDCS resulted in decreased PD when confronted with emotional images, irrespective of valence | [
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pubmedcausal_26604 | The causal associations between all eligible traits and CES were largely mediated through AF, while most traits affected AS and AIS independently of AF | [
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pubmedcausal_13105 | Quadriceps weakness is a hallmark of total knee arthroplasty and is driven by reduced voluntary muscle activation following the surgical procedure. The mechanisms underlying postoperative activation deficits are not well established, although nociception has been implicated via both spinal reflex and supraspinal pathwa... | [
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pubmedcausal_21143 | Diaskintest is highly specific and safe, therefore it is a valuable tool as a screening test for early detection of tuberculosis | [
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pubmedcausal_12803 | Complementary MR and RbG causal methodologies, together with a range of sensitivity analyses, suggest that higher BMI is likely to cause worse cardiovascular health, specifically higher BP and LVMI, even in youth. Higher BMI also resulted in increased CO in the RbG study, which appeared to be solely driven by SV, as ne... | [
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pubmedcausal_29357 | The association of ALL risk with paint exposure was strong, consistent with a causal relationship, but further studies are needed to confirm the association of ALL and AML risk with solvent exposure | [
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pubmedcausal_20521 | This MR analysis provides evidence for a causal relationship between whole-body iron status and CHD development. Our study suggests that a high iron status may be associated with a reduced risk of developing CHD | [
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pubmedcausal_4205 | The study revealed that hepatitis B, hepatitis C, and alcohol consumption were the primary contributors to the increasing DALYs from liver cancer, with population growth and ageing as key drivers of these changes. These findings underscore the importance of considering the major factors and demographic dynamics in addr... | [
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pubmedcausal_5046 | Our study revealed a positive causal relationship between genetically predicted MetS and lung cancer, lung squamous cell carcinoma, endometrial cancer, colorectal cancer, hepatic cancer, non-follicular lymphoma cancer, primary lymphoid and hematopoietic malignant neoplasm cancer, and thyroid cancer, and a negative caus... | [
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pubmedcausal_7428 | Crude associations between lipid levels and risk of subsequent LBP in individuals without current LBP are mainly caused by confounding with body mass. However, an association with low HDL levels may still remain in men who are already affected and possibly experience a higher pain intensity | [
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pubmedcausal_7276 | Causality cannot be established due to the cross-sectional nature of the data, and the self-report nature of our data from a volunteer sample may be influenced by measurement bias or social desirability, or both | [
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pubmedcausal_25505 | RA correlates with an elevated prevalence of HF within the US population. Furthermore, genetic evidence derived from European populations underscores a causal link between RA and the risk of HF. However this association was not significant in SRA | [
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pubmedcausal_4610 | Our feedback theory is organized around seven categories: cognitive vulnerabilities, avoidant coping, high-risk behaviors, family conflict, social support, cultural socialization, and ethnic identity. A reinforcing loop of cognitive vulnerabilities, avoidant coping, high-risk behaviors, and family conflict was more com... | [
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pubmedcausal_22742 | Symbolic, cultural, and social factors were evidenced, thereby leading to the underestimation of biomedical treatments and imparting a greater degree of importance to psychogenic or alternative therapies. These therapies will subsequently affect the achievement of therapeutic objectives such as increased survival | [
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pubmedcausal_6605 | Our study demonstrated a causal relationship between immune traits and EM, and the results were verified by clinical samples. The study may provide new biomarkers for the early diagnosis and immunotherapy of EM | [
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pubmedcausal_26756 | This study identified GM and blood metabolites causally associated with PPD. The results of this study may provide a theoretical basis for the discovery of PPD-related biomarkers and the treatment of the disease by regulating the gut microenvironment | [
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pubmedcausal_26815 | This study has unveiled the causal relationship between gut microbiota and SRPs, bestowing significant latent value upon future endeavors in both foundational research and clinical therapy | [
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pubmedcausal_18311 | Multivariable linear regression and IPTW suggested an association between IPVA and higher depressive symptom score in women but not men, but DiD analysis indicated a null effect in both women and men. This suggests the causal origins of higher depressive symptoms in this young adult population are likely to reflect pri... | [
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pubmedcausal_26392 | Previous observational studies have discovered a connection between depression and mineral status. Confirming this potential connection is challenging due to confounding factors and potential reverse causality which is inherent in observational studies | [
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pubmedcausal_18291 | Our findings support a causal effect that a genetic predisposition to systematically higher TB-BMD was associated with the risk of OA. And, TB-BMD likely exerts an effect on the risk of hip OA not knee OA | [] |
pubmedcausal_4993 | This study provides robust evidence supporting a causal relationship between elevated bilirubin and a reduced risk of vitiligo, driven by its antioxidant properties. The identified DEGs and enriched pathways further elucidate the molecular mechanisms of bilirubin in the pathogenesis of vitiligo through oxidative stress... | [
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pubmedcausal_10899 | We used causal directed acyclic graphs to illustrate potential confounding related to previous pregnancies and exposure measurement error due to differences in the interpregnancy interval in pregnancy-based studies that include parous women. We exemplified the potential importance of these issues using data from the Da... | [
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pubmedcausal_10524 | This study demonstrated an inverse dose-response association between levels of physical activity and multimorbidity, however, given the increasing prevalence of multimorbidity over time, there is a need to explore causal associations between physical activity and multimorbidity and its impact as a primary prevention st... | [
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pubmedcausal_14945 | These results suggest that there is some correlation between atrophy of the multifidus and pain intensity. Consequently, focusing on the CSA of the multifidus muscle may help to clarify the causes of LBP in patients with LSS. However, because of the cross-sectional nature of this study, causal relationships could not b... | [
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pubmedcausal_17459 | Due to the cross-sectional study design, the present findings allow only hypothetical assumptions of causality | [
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pubmedcausal_29239 | Intrastent thrombosis, while rare, has a poor prognosis. Strut non-coverage is one causal factor, especially in cases of resistance to or premature discontinuation of dual antiplatelet therapy | [
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pubmedcausal_15958 | Opioid agonist therapy may increase uptake of HIV testing among people who inject drugs, providing further evidence that opioid agonist therapy improves the HIV treatment care cascade | [
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pubmedcausal_16663 | Natural or quasi experiments are appealing for public health research because they enable the evaluation of events or interventions that are difficult or impossible to manipulate experimentally, such as many policy and health system reforms. However, there remains ambiguity in the literature about their definition and ... | [] |
pubmedcausal_26286 | This study offers proof of causality between RA and an increased risk of CI. Our findings highlight the importance of examining RA patients for cognitive ability, which may open up fresh ideas for the prevention of CI | [
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pubmedcausal_27503 | This study has identified a causal association between Actinomycetota, Holdemanella, and PDD through MR analysis. These findings offer significant contributions to the development of personalized treatment approaches for PPD, encompassing interventions such as dietary modifications or microbiome interventions | [
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pubmedcausal_12249 | Based on the first-order structure, our proposed model utilizes non-entity tokens between separated entities as an information transmission medium by applying a label induction method. The model is referred to as precursor-induced CRF because its non-entity state memorizes precursor entity information, and the model's ... | [] |
pubmedcausal_3954 | Diarrheic disease is a common intestinal health problem worldwide, causing great suffering to humans and animals. Precise manipulation strategies based on probiotics to combat diarrheic diseases have not been fully developed | [
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pubmedcausal_24650 | Our findings provide compelling evidence supporting causal relationships between dietary habits and stroke subtypes, while identifying mediators and evaluating the proportions of mediation. Adhering to a low-calorie, nutrient-dense diet enriched with dried fruits, cheese, and cereal, along with reduced salt and poultry... | [
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pubmedcausal_5440 | Genetically predicted ankylosing spondylitis increased the risk of heart failure, and the causality may partly be mediated by increased arterial stiffness | [
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pubmedcausal_4823 | Menopause is a natural process that often leads to physical and emotional symptoms affecting women's quality of life. Nutrition is increasingly recognized as important in managing these symptoms, with certain dietary patterns-particularly those rich in fiber and whole grains-showing potential benefits. In many regions,... | [
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pubmedcausal_1065 | ADRs are common in hospitalized children and children who had undergone a GA had more than six times the risk of developing an ADR. GA agents and opiate analgesics are a significant cause of ADRs and have been underrepresented in previous studies. This is a concern in view of the increasing number of pediatric short-st... | [
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pubmedcausal_8835 | Job stress and emotional exhaustion have been shown to have a negative impact on the helping professional. The development and causal relations of job stress and emotional exhaustion are rather unclear in the chiropractic profession. The objective of this study is to understand the main sources of occupational stress a... | [
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pubmedcausal_29003 | Cigarette smoking is an established causal factor for atherosclerosis. However, the smoking effect on different echogenic components of carotid arterial wall measured by ultrasound is not well elucidated | [
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pubmedcausal_25947 | Our findings confirm the causal relationship between GM and facial skin aging, providing a new perspective on delaying facial aging | [
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pubmedcausal_5134 | The available evidence suggests that clinicians' use of the Naranjo Adverse Drug Reaction Probability Scale to determine the potential of hyperkalemia occurring due to exposure to unfractionated heparin and low-molecular-weight heparin is limited. Clinicians should be encouraged to utilize an objective monitoring tool ... | [
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pubmedcausal_17917 | Our results provide some that genetically determined hypothyroidism decreases the risk of HCC, although the size of the causal estimate is small. Further research is required to comprehend the mechanisms underlying this putative causative association, and follow-up clinical trials need to be conducted to establish whet... | [
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pubmedcausal_26679 | Our analyses provided robust evidence of causal associations between blood metabolites on sciatica or/and lower back pain. However, the underlying mechanisms remain to be further investigated | [
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pubmedcausal_15687 | No significant changes in workplace culture were found over time. However, awareness of caregiver-friendly workplace programs is shown to positively impact the amount of support received, which sequentially improves workplace experience, and ultimately workplace culture. This therefore suggests that the implementation ... | [
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pubmedcausal_3831 | Gut microbiota and blood metabolites are causally linked to VC. These findings provide a theoretical basis for microbiome- and metabolome-based therapeutic strategies for targeting VC and enhances our comprehension of the gut-vascular axis | [
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pubmedcausal_21772 | BMI and insulin both causally decreased serum sOb-R levels. Conversely, intensive exercise and food intake acutely increased sOb-R. Our results suggest that sOb-R is involved in short-term regulation of leptin signaling, either directly or indirectly, and that hyperinsulinemia may reduce leptin signaling | [
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pubmedcausal_26494 | This study established a causal association between specific GM and DN. Our findings contribute to current understanding of the role of GM in the development of DN, offering potential insights for the prevention and treatment strategies for this condition | [
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pubmedcausal_5191 | These findings provided new evidence of the causal relationship between psoriasis and BP. Our MR suggested that psoriasis is potentially causal to BP, which helps us to improve the treatment strategy for patients with psoriasis. The mechanism remains open for further investigation | [
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pubmedcausal_20230 | Two-sample MR analysis showed inverse associations between genetically predicted BMI and BCC risk. Moreover, when exposure and outcome were switched to see if reverse causation was possible, there was no evidence of a cause-and-effect relationship from BCC to BMI. Finally, the meta-analysis also showed a strong negativ... | [] |
pubmedcausal_23434 | Autistic traits are positively associated with the stress of social isolation. Autistic traits affected core self-evaluation first, and psychological inflexibility subsequently, leading to the stress of social isolation. individuals with high autistic traits tended to experience higher levels of stress during pandemic ... | [
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pubmedcausal_5065 | Through MR analysis, this study offers evidence of a causal link between apoA-I with COPD. This further substantiates the potential role of lipid metabolism in COPD, and has significant clinical implications for the prevention and management of COPD | [
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pubmedcausal_26627 | Our study provides new causal evidence for the link between gut microbiota and liver cirrhosis, which may contribute to the discovery of novel strategies to prevent liver cirrhosis | [
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pubmedcausal_18966 | In summary, our study confirmed that the novel CRL signature could effectively evaluate prognosis, tumor immune microenvironment, and immunotherapy response in OS. It may benefit for clinical decision-making and provide new insights for personalized therapeutics | [
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pubmedcausal_26079 | Our study provides robust evidence supporting a causal link between higher birth weight and longer telomere length | [
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pubmedcausal_29457 | Aside from a lower prevalence, depression is very similar in this predominantly urban Sri Lankan sample to higher-income, Western countries, and may be under-identified due to a relatively low cultural appropriateness of the assessment of impairment. Under Sri Lanka's cultural and environmental context, certain aspects... | [
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pubmedcausal_14577 | Cross-sectional and longitudinal studies have consistently reported an association between education and myopia. However, conventional observational studies are at risk of bias due to confounding by factors such as socioeconomic position and parental educational attainment. The current study aimed to estimate the causa... | [
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pubmedcausal_27980 | This study showed positive causal relationships between RA and osteoporotic fracture. These results should be considered in further studies and public health measures on osteoporosis prevention strategies | [
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pubmedcausal_17234 | We found a causal relationship between DLPFC and self-compassion. We also provide evidence to indicate widespread gamma activity and connectivity to correlate with self-compassion as well as the critical role of the DLPFC in modulating theta activity and negative emotions | [
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pubmedcausal_27773 | Our results provide strong evidence that multiple immune cells have a causal effect on the risk of myocardial infarction. This discovery provides a new avenue for the development of therapeutic treatments for myocardial infarction and a new target for drug development | [
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pubmedcausal_3732 | Inflammation is one of the main causes of ovarian cancer. Depression leads to an increase in pro-inflammatory cytokines, which in turn affects the progression and severity of cancer. There is a lack of research on the relationship between depression severity and ovarian cancer. This study aimed to explore the relations... | [
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pubmedcausal_22005 | This study sheds light on the intricate relationship between nurses' job embeddedness, missed care, and polychronicity in the operating theater context. By enhancing job embeddedness and fostering polychronicity among nurses, healthcare organizations can reduce perioperative missed care and ultimately improve patient c... | [
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pubmedcausal_23704 | The results of a path analysis showed that depression had a positive effect and well-being had a negative effect on physical inactivity, which in turn contributed to the likelihood of severe bodily pain, activity limitations, poor self-rated health, and multimorbidity. Depression and well-being contributed to health-re... | [
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pubmedcausal_26562 | The MR analysis results suggested that chronotype is associated with decreased levels of six hormones in HPTGA. Sleep duration was causally associated with decreased levels of free thyroxine and progesterone. Both long and short sleep durations are detrimental to the secretion of prolactin-releasing peptide, somatostat... | [
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pubmedcausal_7713 | Clinical pharmacists working on an admissions ward in a UK hospital identified patients admitted due to suspected MRH. Six different data sources in each patient's medical record, including the discharge summary, were subsequently examined for MRH-related information. Each data source was examined for statements descri... | [
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pubmedcausal_21386 | Various system responses to shocks were identified, including demand promotion measures such as scaling-up community engagement activities and policy changes to reduce the cost of vaccination to service users, and supply side responses including donor funding mobilisation, diversification of service delivery models and... | [
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pubmedcausal_1413 | A major cause of cancer-related deaths is the development of liver metastasis. To better understand the metastatic process, we studied the cotton top tamarin as an animal model, which spontaneously develops colorectal cancer but rarely liver metastasis | [
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pubmedcausal_26923 | The present MR study provides evidence of a causal, protective relationship between non-oily fish intake and reduced epilepsy risk. Additionally, the findings suggest that epilepsy may influence water intake patterns. These results contribute to our understanding of the role of dietary factors in epilepsy and may infor... | [
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pubmedcausal_25218 | These findings support a causal effect of elevated blood pressure on retinal ganglion cell degeneration that does not require intermediary changes in IOP. Targeted blood pressure control may help preserve vision by lowering IOP and, independently, by preventing retinal ganglion cell degeneration, including in individua... | [
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pubmedcausal_28451 | Within the constraints and assumptions of causal modeling, there is evidence that both war trauma and sexual trauma are powerful contributors to the development of posttraumatic stress disorder among female Vietnam veterans | [
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pubmedcausal_28016 | This study found a decrease in the number of OA cases, as well as changes in economic sectors and causal agents associated with OA and OHP, specifically, in the agricultural sector, with MWFs from the industrial manufacturing sector now being the most common aetiological agent | [
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pubmedcausal_8003 | Six main proximal causal factors are identified: a worry thinking style, negative beliefs about the self, interpersonal sensitivity, sleep disturbance, anomalous internal experience, and reasoning biases. Each has plausible mechanistic links to the occurrence of paranoia. These causal factors may be influenced by a num... | [
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pubmedcausal_12555 | DNA methylation has recently been identified as a mediator between in utero famine exposure and a range of metabolic and psychiatric traits. However, genome-wide analyses are scarce and cross-sectional analyses are hampered by many potential confounding factors. Moreover, causal relations are hard to identify due to th... | [
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pubmedcausal_5624 | This MR study provides new evidence on the direct causal effects of thin childhood body size on the risk of mandibular retrognathia, emphasizing the critical role of early childhood nutrition and weight management in craniofacial development | [
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pubmedcausal_26768 | This investigation confirmed that IBD and CD had a causal connection with EN, whereas UC did not. In addition, EN may decrease the likelihood of UC. Further study must be performed to uncover the underlying pathophysiological mechanisms producing that connection | [
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pubmedcausal_21560 | Hospitalised patients are especially vulnerable to malnutrition, which is associated with an increased risk of complications, leading to longer hospital stays, increased healthcare costs, and with a potentially negative effect on the prognosis. Poor oral health may make food intake difficult and contribute to poor nutr... | [
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pubmedcausal_25609 | Our comprehensive MR study demonstrated that depression and lower educational attainment were causal factors for FD at the genetic level | [
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pubmedcausal_11181 | Dyslipidemia is a major risk factor for cardiovascular disease, the leading cause of preventable death worldwide. As a result, a full understanding of the factors influencing dyslipidemia is urgently necessary. Bile acids have been recognized as regulators of lipid metabolism, and neutral sterols may influence serum li... | [
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62
],
[
85,
112
],
[
0,
112
],
[
127,
209
]
] |
pubmedcausal_27687 | This study did not find evidence of a bidirectional causal relationship between genetically predicted insomnia and hyperthyroidism, hypothyroidism, thyroiditis, and thyroid nodules. However, we found that although insomnia does not increase the risk of thyroid cancer, thyroid cancer does increase the risk of insomnia | [
[
253,
267
]
] |
pubmedcausal_17625 | No significant differences were found in age, physical characteristics, and cigarette use between participants who completed all the follow-ups and those who dropped out. Findings indicated that a high level of PSMU significantly increased the level of anxiety and a high level of anxiety significantly increased the lev... | [
[
195,
215
],
[
216,
260
],
[
265,
288
],
[
289,
330
],
[
332,
352
],
[
353,
400
],
[
477,
495
],
[
613,
639
],
[
640,
679
]
] |
pubmedcausal_25244 | The causal loop diagram highlights that prioritization of undernutrition over overnutrition in the policymaking process, due to Peru's historically high levels of undernutrition, may undermine action against the DBM. It also describes potential mechanisms of unintended impacts of undernutrition policies on the DBM in P... | [
[
128,
177
],
[
40,
119
],
[
474,
491
],
[
259,
323
]
] |
pubmedcausal_19099 | The results demonstrated a sequential style of supervision can positively impact student engagement and confidence, and highlighted a need to address student preparation for remote patient examinations. Students found passive observation of remote patient encounters disengaging, and, in addition, reported isolation tha... | [
[
25,
58
],
[
63,
99
],
[
120,
201
],
[
322,
394
],
[
298,
316
]
] |
pubmedcausal_27590 | This study represents the first evidence suggesting a potential causal relationship between childhood obesity, age at menarche, and ovarian dysfunction. Childhood obesity was found to increase the risk of ovarian dysfunction, while a later age at menarche was associated with a reduced risk of ovarian dysfunction | [
[
153,
170
]
] |
pubmedcausal_5219 | This study revealed that BN has a causal effect on WM microstructure, which extends the reports of association to causation for WM and BN. These causal effects may explain the deficits in feeding, taste, vision, and emotion regulation that are often observed in patients with BN. Level of evidence III well-designed coho... | [
[
25,
27
],
[
51,
68
]
] |
pubmedcausal_5839 | Our findings indicate that mood influences alcohol- and nicotine use and vice versa in individuals with BD, although caution should be taken due to the exploratory approach. Larger samples are needed to further disentangle these relationships to provide insight for better prevention and treatment of BD and comorbid sub... | [
[
148,
172
],
[
117,
140
]
] |
pubmedcausal_10615 | The identification of factors related to the development of AP increases our knowledge of its physiopathology. Moreover, identifying antigens that possibly trigger the allergic reaction will have preventive and therapeutic applications in populations at risk of AP | [
[
4,
62
]
] |
pubmedcausal_20224 | A lower BMI might be causally associated with increased risk of TMDs, supporting the importance of weight control for the prevention of TMDs. Clinicians should pay more attention to the low-BMI patients among those seeking medical advice due to temporomandibular joint discomfort | [
[
245,
279
],
[
142,
237
]
] |
pubmedcausal_17276 | The participant derived CLD of factors influencing AMR in the SEA food system demonstrates that AMR is a product of numerous interlinked actions taken across the One Health spectrum and that finding solutions is no simple task. Developing the model enabled the identification of potentially promising leverage points acr... | [
[
706,
720
],
[
734,
784
]
] |
pubmedcausal_2024 | Association between C.pneumoniae infection and CV disease depends on the analytical method adopted, which seems stronger with stroke due to large artery atherosclerosis. Establishing a causal relationship between C.peumoniae infection and CV disease will require more prospective studies with combination of techniques a... | [
[
140,
168
]
] |
pubmedcausal_27285 | Our MR analysis demonstrated a causal relationship between elevated SUA levels and an amplified risk of IAs. Further rigorous investigations are imperative to provide evidence and elucidate the underlying mechanisms | [
[
59,
78
],
[
86,
107
]
] |
pubmedcausal_23698 | Compared with controls, the gut microbiota of CRC patients showed an increase in the abundance of Enterococcus, Fusobacterium and Streptococcus. At the species level, the CRC enriched bacterium including Escherichia coli, Enterococcus faecalis, Fusobacterium nucleatum, Streptococcus gallolyticus, Flavoni fractorplautii... | [
[
46,
49
]
] |
pubmedcausal_3757 | The findings indicate a weak relationship between dental anxiety and neglect, which implies that dental fear can be a potential factor that causes dental care delays among adults in Islamabad. Sociodemographic variables, including gender, income, and insurance status, also determined dental behavior. Future studies on ... | [
[
432,
474
],
[
302,
388
]
] |
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