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pubmedcausal_24585 | Our findings support a causal link between increased residential greenness exposure and a reduced risk of CVD mortality in South China with marked heterogenous effects, which has public health implications for cultivating greener urban environments to mitigate the impact of CVD within the context of rapid urbanization | [
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pubmedcausal_1522 | Vision and HL are highly prevalent among older adults and their co-occurrence may compound their respective impacts on health, functioning, and activity engagement, thereby exerting strong effects on the mental health and wellbeing of those affected. There is therefore a need for rehabilitation programs to be sensitive... | [
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pubmedcausal_14713 | According to WHO's statistical evidence, accidental falls are the second leading causes of death worldwide. This systematic literature review and meta-analysis aims to provide a holistic view of risk factors and unfold the missing or less addressed but crucial factors that lead to accidental falls of the older adults. ... | [
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pubmedcausal_27487 | People with schizophrenia have a higher risk of mortality compared to the general population, which has not improved over time. The majority of premature deaths are due to comorbid physical diseases, driven by interrelated factors operating at the individual level, through health systems and influenced by social determ... | [
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pubmedcausal_17698 | Suicide is a major public health problem and a cause of premature mortality. With a view to prevention, a great deal of research has been devoted to the determinants of suicide, focusing mostly on individual risk factors, particularly depression. In addition to causes intrinsic to the individual, the social environment... | [
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pubmedcausal_12923 | Incidence of ADRs with fondaparinux was lower than with heparin, hence emphasizing its better safety profile. The study also highlights the need for nurses and other caretakers in the coronary care unit to enquire for and report ADRs, particularly with high-potency medicines that are associated with an equally high pot... | [] |
pubmedcausal_11076 | Our data suggest that variation in physiological stress parameters and poor decision-making abilities increase risk of stress-induced alcohol consumption. This may provide a useful translational framework through which we can further study early predictive markers for the shift between controlled recreational drinking ... | [
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pubmedcausal_14048 | Our results are consistent with a causal relationship between hepatic fat and HCC. PRS improved the accuracy of HCC detection and may help stratify HCC risk in individuals with dysmetabolism, including those without severe liver fibrosis. Further studies are needed to validate our findings | [
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pubmedcausal_5148 | This study identifies specific causal relationships between dietary antioxidants and ED, providing a foundation for understanding the pathogenesis of ED, guiding the development of dietary intervention strategies, and informing clinical treatment approaches | [
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pubmedcausal_10370 | Inverse associations between urinary arsenic concentration with BMI and waist-to-height ratio were observed when either creatinine or osmolality were used to standardize or as covariates. Not adjusting for dilution, standardizing or adjusting for urinary flow rate, and using covariate-adjusted standardization resulted ... | [
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pubmedcausal_16308 | We identified specific pathogenic bacteria features that were causally associated with the risk of IBD, thus offering new insights into the prevention and diagnosis of IBD | [
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pubmedcausal_27728 | The study reveals that genetically predicted insomnia significantly increases the risk of unspecified pain, chest pain, gum pain, upper abdominal pain, and lower abdominal pain occurrence. Daytime napping is associated with a moderate reduction in the likelihood of joint pain but may concomitantly elevate the risk of c... | [
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pubmedcausal_6557 | There is a robust causal association between obesity and NICM, and with abnormalities in myocardial structure and function. HTN emerges as a pivotal mediator in the obesity-NICM pathway, underscoring the critical role of managing obesity and HTN in preventing NICM progression | [
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pubmedcausal_3070 | Ligament damage emerged as the most impactful iatrogenic factor promoting ASDeg and ASDis development. Similarly, muscle damage had a significant impact on long-term musculoskeletal health, with muscle-sparing approaches potentially reducing ASDis rates. Immobilization led to compensatory increased motion at adjacent s... | [
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pubmedcausal_23959 | This comprehensive investigation of SNPs in DEGs and DEPs identified a significant number of SNPs and genes related to skeletal muscle development during the prenatal stage. These findings not only shed light on potential causal genes for muscle divergence between the TIBP and LWP breeds but also offer valuable insight... | [
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pubmedcausal_4069 | Twin gestation, regardless of known risk factors, increases the risk of placenta accreta and adverse perinatal outcomes compared to singleton pregnancies. Antenatal interventions and delivery risk management are essential for twin pregnancies with placenta accreta | [
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pubmedcausal_16644 | The current study investigates the efficacy of communications focused on two primary causes of obesity: genes and environment | [
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pubmedcausal_25901 | This study provides novel evidence of the causal relationships between specific brain morphometries and KOA, suggesting that neuroanatomical variations might contribute to the risk and development of KOA. These findings pave the way for further research into the neurobiological mechanisms underlying KOA and may eventua... | [
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pubmedcausal_21558 | The present study is based on cross-sectional data, which limits the ability to infer causal relationships | [
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pubmedcausal_8342 | Motherhood care of disabled children is a unique phenomenon which is due to attachment of mother-child situation. Nevertheless, these mothers are vulnerable and marginalized people who need more attention and social supports provided by related governmental institutions and also NGOs actors | [
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pubmedcausal_20155 | In this study, we prove that hypothyroidism is significantly causally associated with increased RA risk, which has not been shown in previous studies. Furthermore, we pinpoint the potential causal variants in RA | [
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pubmedcausal_19049 | The research illustrates that the managers of start-ups can improve employees' affective commitment by giving full play to entrepreneurial leadership and combining the career growth opportunities provided by the organization. Employees' tacit knowledge sharing behavior is stimulated, providing guiding value for knowled... | [
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pubmedcausal_1950 | This paper is motivated by the theory that developmental idealism has been disseminated globally and has become an international force for family and demographic change. Developmental idealism is a set of cultural beliefs and values about development and how development relates to family and demographic behavior. It ho... | [
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pubmedcausal_12035 | Bodybuilding supplements can cause a profound cholestatic syndrome | [
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pubmedcausal_29178 | Warfarin affects the synthesis and function of the matrix Gla-protein, a vitamin K-dependent protein, which is a potent inhibitor of tissue calcification | [
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pubmedcausal_1571 | Study data was cross-sectional and obtained through self-report, thus limiting causal explanations of results | [
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pubmedcausal_1558 | Offspring of parents with bipolar disorder are at increased risk for a range of psychopathology, including bipolar disorder. It is not clear if they also have impairments in their psychosocial functioning | [
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pubmedcausal_27053 | The present study determined the causal effect between waist circumference and TB by two-sample MR analysis and found both to be likely to be potential risk factors | [
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pubmedcausal_8407 | While the number of deceased donors is higher than the number of living donors, opt-out consent leads to a relative increase in the total number of livers and kidneys transplanted | [
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pubmedcausal_17680 | An acute change of serotonin levels can increase insight into the reliability of inferences made from cardiac interoceptive sensations | [
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pubmedcausal_16865 | The source of "background knowledge" should be evaluated with care. Knowledge generated on preceding studies can cause misspecification | [
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pubmedcausal_6551 | This study demonstrated a causal relationship between eight fatty acid metabolisms and PE. Follow-up in-depth randomized controlled trials are needed to reveal the promotional or protective effects of fatty acid metabolism on PE | [
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pubmedcausal_11071 | Motor vehicle crashes remain the leading cause of teen deaths in spite of preventive efforts. Prevention strategies could be advanced through new analytic approaches that allow us to better conceptualize the complex processes underlying teen crash risk. This may help policymakers design appropriate interventions and ev... | [
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pubmedcausal_27472 | Our research reveals that increasing Lachnospiraceae abundance in the gut can directly enhance limb muscle mass and concurrently suppress AOPEP, consequently mitigating limb muscle loss. This supports the potential therapeutic modulation of gut microbiota for sarcopenia. Interventions such as drug treatments or microbi... | [
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pubmedcausal_12863 | News claims-even headlines-can become better aligned with evidence. Cautious claims and explicit caveats about correlational findings may penetrate into news without harming news interest. Findings from AT analysis are correlational and may not imply cause, although here the linking mechanism between press releases and... | [
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pubmedcausal_27536 | According to the bidirectional MR investigation shows a significant causal relationship among obesity and CRC in the Mets component but no causal relationship in the opposite direction | [
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pubmedcausal_27347 | Our MR analysis provides robust evidence of the causal role of ADHD in increasing the risk of ASD and schizophrenia. However, ADHD is not associated with the risk of Tic Disorder, Mental Retardation, Mood Disorders and Anxiety Disorder. This suggests the need for increased attention to the co-occurrence of ADHD-ASD or ... | [
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pubmedcausal_209 | Opioid switching has been found to improve opioid responsiveness in different conditions. However, data on opioid switching performed at home are almost nonexistent, despite the fact that most patients are followed at home | [
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pubmedcausal_20043 | Long working hours have been reported to cause various health problems, but are currently practiced in many countries. Building upon a previous cross-sectional study, the authors aimed to elucidate the causal relationship between long working hours and hypothyroidism through a longitudinal study | [
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pubmedcausal_24548 | This study reveals how city shrinkage disrupts health service provision and equity, establishing a causal relationship between city shrinkage/expansion and health resource allocation, emphasizing the imbalance caused by urban population changes. City expansion intensifies competition for health resources, while shrinki... | [
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pubmedcausal_4490 | The natural distributions of ambient air pollutants are often correlated. Existing studies have found that exposures to various air pollutants are associated with elevated risks of asthma symptoms among children. However, most studies applied single-pollutant models, which cannot distinguish between causal effects and ... | [
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pubmedcausal_9030 | In conclusion, the observed high prevalence of the two metacestodes larval stages leads to high condemnation rates of edible offals and raises significant public health concerns. This underscores for the need to undertake more extensive epidemiological investigations to better determine the causal factors, economic imp... | [
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pubmedcausal_9596 | Our review supports a possible dose-response type of association between chronic pain and cardiovascular disease, supported by a range of observational studies originating from different countries. Such research has so far failed to satisfactorily rule out that the association is due to confounding variables. What is n... | [
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pubmedcausal_21653 | Despite low global genetic correlation, the current results provide evidence for polygenic overlap between AD and MS. The shared loci between AD and MS were enriched in pathways involved in inflammation and neurodegeneration, highlighting new opportunities for future investigation | [
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pubmedcausal_24609 | This study identified a causal relationship between the daily dietary intake of sugars and fats, as well as the magnesium and vitamin D levels in serum, and the occurrence of CA. However, further in-depth research is warranted to elucidate the specific mechanisms underlying these associations | [
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pubmedcausal_16993 | The reduction in ischemic heart disease in epilepsy is a novel and highly significant finding, which reflects widespread implementation of cardiovascular risk-factor reduction and treatment in the United States. Reductions in epilepsy-related deaths are an exciting development which requires further investigation into ... | [
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pubmedcausal_20685 | Testosterone is an essential sex hormone that plays a vital role in the overall health and development of males. It is well known that obesity decreases testosterone levels, but it is difficult to determine the causal relationship between body composition and testosterone | [
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pubmedcausal_16429 | A low level of education is a causal risk factor in the development of breast cancer as it is associated with poor lipid profile, obesity, smoking, and types of physical activity | [
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pubmedcausal_27715 | The findings revealed strong genetic evidence for causal links between SLE and neuroimaging phenotypes. Our results provide a promising method for the daily assessment and monitoring of SLE patients | [
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pubmedcausal_4408 | The findings suggest a differential association between the severity of periodontitis and the type of CAC. Unilateral CAC may be more strongly linked to advanced periodontal inflammation, possibly reflecting an earlier, inflammation-dominant phase of atherosclerosis. Due to the cross-sectional design and use of panoram... | [
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pubmedcausal_23429 | These findings supported that maintaining stable SBP in late life helped lower the risk of AD, partially by modulating amyloid pathology, cerebral metabolism, and cerebrovascular health | [
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pubmedcausal_26511 | Anxiety disorders were causally associated with greater risk of CHD, MI, and HF but not AF among individuals of European descent. Further research on mediating mechanisms and in diverse populations is warranted | [
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pubmedcausal_27348 | Glaucoma, a leading cause of global blindness, is characterized by optic nerve damage and visual field loss. Previous studies have suggested a potential association between glaucoma and anxiety disorders. However, the causal relationship between these two conditions remains unclear | [
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pubmedcausal_25959 | Our study provided genetic evidence on the causal relationship between periodontitis and endometriosis of the pelvic peritoneum. More studies are necessary to explore the underlying mechanisms | [
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pubmedcausal_7020 | The associations between active commuting to school and cognitive performance and academic achievement are weak and might be moderated by sex, while the greatest benefits on cognition due to active commuting to school might be with regard to executive functioning. Future studies might make use of experimental designs, ... | [
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pubmedcausal_4791 | Most AW&RS were IDSR and cohort-based surveillance. Climate changes have resulted in observed trends in diseases such as malaria and RVF, but further studies are needed to determine causal links. Insufficient funding hinders the effective implementation of AW&RS. Future research should assess the cost drivers influenci... | [
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pubmedcausal_14235 | In this research, healthy volunteers from three different human populations were phenotyped with the Geneva cocktail. Four adverse events were observed, confirming the safety of this cocktail that is given at lower than clinically relevant doses and therefore results in concentrations lower than those reported to cause... | [
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pubmedcausal_11857 | A comprehensive iterative approach is presented by combining the elements of the MRC Framework development phase with essential elements from existing guidance including: problem identification, the systematic identification of evidence, identification or development of theory, determination of needs, the examination o... | [
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pubmedcausal_27050 | The evidence from observational studies indicates a positive correlation between HUA and the onset of DN. And the causal effects of HUA on DN were supported by the MR analysis | [
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pubmedcausal_5096 | The study highlights causal associations between MMPs and cervical lesions, suggesting their potential as therapeutic targets and biomarkers for early detection. Future research should further explore the mechanisms involved | [
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pubmedcausal_5026 | This study provides compelling evidence from MR supporting a unidirectional causal link between SUA levels and increased hypertension risk. Unlike prior observational studies, our genetic approach effectively mitigates confounding and reverse causation, offering novel insights into the etiology of hypertension. These f... | [
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pubmedcausal_27971 | Based on this MR analysis, we found a causal relationship between certain gut microbial communities and PPD. Future clinical studies can further explore the treatment of PPD through the combined use of microorganisms. This not only offers insights into the pathogenesis of PPD but also lays the foundation for utilizing ... | [
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pubmedcausal_7191 | Possible adverse drug events led to hospitalization in a high-complexity hospital, mainly in polymedicated patients. The clinical outcomes of adverse drug events are nonspecific, which delays treatment, hinders causality analysis, and contributes to the underreporting of cases | [
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pubmedcausal_29627 | After controlling for these confounding factors, results of cross-lagged effects modelling showed that adoption of a Diversion coping strategy decreased caregiver burnout, while increases in burnout decreased caregiver Positive Acceptance of Caregiving Role | [
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pubmedcausal_4172 | Our study found a non-linear dose correlation between physical activities and depressive symptoms. The dose-response connection between different physical activity types and depressive symptoms varies between rural and urban areas. Recreational physical activity is recommended for urban and reasonable amounts of nonrec... | [
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pubmedcausal_560 | Multiple case series, mostly highly selected, have demonstrated a very high mortality following acute basilar artery occlusion. The more widespread availability and use of non-invasive vascular imaging over recent years has increased the rate of ABAO diagnosis | [
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pubmedcausal_14838 | While obesity confers an increased risk of death in the general population, numerous studies have reported an association between obesity and improved survival among critically ill patients. This contrary finding has been referred to as the obesity paradox. In this retrospective study, two causal inference approaches w... | [
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pubmedcausal_24131 | Three and seven kinds of codes in the domains of "body functions" and "activities and participation", respectively, were identified on the care recipients' side; whereas on the caregivers' side, one and five kinds of codes in the domains of "body functions" and "activities and participation", respectively, were found. ... | [
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pubmedcausal_20627 | Our study provides evidence of a causal relationship between hyperthyroidism and the risk of prostate cancer, rectal cancer, and leukemia. Further research is needed to clarify the associations between hyperthyroidism and other cancers | [
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pubmedcausal_28400 | Because published data have typically focused on specific patient populations, diagnoses, or procedures, there are few data regarding surgical deaths and complications in institutional or regional studies. Specifically, surgical adverse events and errors are generally not studied comprehensively. This limits the overal... | [
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pubmedcausal_8368 | In smokers with exertional dyspnea and/or a nonproductive cough, SR-ILDs must be considered in the differential diagnosis. If an SR-ILD is suspected, the patient should be referred to a pulmonary specialist. Early treatment and smoking cessation can improve clinical outcomes, particularly in the acute and chronically p... | [
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pubmedcausal_4468 | Exposure to arsenic increases the risk of hypertension. Indeed, a high level of arsenic in human serum, a reliable biomarker of arsenic exposure, was shown to be linked to increased prevalence of hypertension among a study of Japanese residents. However, no beneficial food that decreases the risk of arsenic-mediated hy... | [
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pubmedcausal_25066 | Our study provides evidence of the bidirectional causal association between gut microbiota and PCOS from a genetic perspective | [
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pubmedcausal_12559 | Remediating visual timing deficits in the dorsal stream revealed the causal role of visual movement discrimination training in improving high-level cognitive functions such as focusing and switching attention, working memory, processing speed, and reading. This study found that movement-discrimination training was very... | [
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pubmedcausal_26278 | This study offers MR evidence supporting a bidirectional causal relationship between depression and hemorrhoidal disease | [
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pubmedcausal_19403 | Tackling problematic polypharmacy requires tailoring the use of medicines to individual circumstances and may involve the process of deprescribing. Deprescribing can cause anxiety and concern for clinicians and patients. Tailoring medication decisions often entails beyond protocol decision-making, a complex process inv... | [
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pubmedcausal_24911 | Extensive causal associations were found between GM and diabetic complications, which may provide new insights into the mechanisms of microbiome-mediated complications of diabetes | [
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pubmedcausal_17957 | Simulations: Regular regression analyses without a negative control variable worked poorly in the presence of unobserved confounding. Including a negative control variable improved result substantially. The latent variable approach provided unbiased results in several situations where the other analysis models worked p... | [
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pubmedcausal_17723 | Bayesian combination of modeled exposure and measured biomarker concentrations can reduce exposure measurement error compared to modeled exposure | [
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pubmedcausal_27392 | Through the application of MR, this study provides practical insights into the potential causal association between plasma metabolites and ASD. These findings offer perspectives for the discovery of diagnostic or predictive biomarkers to support clinical practice in treating ASD | [
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pubmedcausal_23662 | Our analysis highlights a strong causal association between Lachnospiraceae and irAEs, along with some other gut microbial taxa. These findings provide potential modifiable targets for managing irAEs and warrant further investigation | [
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pubmedcausal_22668 | Although causality cannot be inferred due to the research design, the findings in this study suggest potential complementary effects of mindfulness meditation and psychedelic use on leadership, which could inspire new approaches in leadership development | [
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pubmedcausal_5661 | There was a positive causal association between PCOS and PIH, whereas there was no causal association with PEC and GDM, and no heterogeneity or pleiotropy was detected | [
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pubmedcausal_18501 | DBP has a causal effect on neuroticism. Appropriate management of blood pressure may reduce neuroticism, neuroticism-inducing mood disorders and cardiovascular diseases | [
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pubmedcausal_15870 | Bearing and rearing a child decreases blood pressure among mothers in India | [
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pubmedcausal_8859 | Keeping girls in school results in a number of benefits for young women; however, protects against lifetime experience of sexual violence only in Uganda. It is possible that overall higher grade attainment, particularly at secondary school levels is driving this effect in Uganda. More research on this relationship is n... | [
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pubmedcausal_27541 | Our study provides strong evidence that hypothyroidism is a causal determinant of ARC risk | [
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pubmedcausal_12596 | Treatment approaches for patients with psychosis need major improvement. Our approach to improvement is twofold: target putative causal mechanisms for psychotic experiences that are treatable and also that patients wish treated. This leads to greater treatment engagement and clinical benefit. To inform mental health se... | [
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pubmedcausal_17082 | Psychological health factors had the most substantial causal effect on health-related quality of life, which was larger than the causal effects of physical and environmental health-related factors. Developing and providing comprehensive interventions are necessary to assess and manage psychological, physical, and envir... | [
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pubmedcausal_17120 | Psychological adjustment during lockdown mediated the relationship between confinement levels and most sexual functioning domains in men but not in women. Also, while confinement levels were not directly related with most sexual functioning domains, psychological adjustment during lockdown did predict lower sexual func... | [
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pubmedcausal_25196 | This study provides MR evidence to support the causal relationship between a broad range of dietary intake and GERD, providing new insights for the treatment and prevention of GERD | [
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pubmedcausal_26314 | Blood metabolites from different metabolism pathways were causally related to the components of sarcopenia. These findings might benefit the understanding of the biological mechanisms of sarcopenia and targeted drugs development for muscle health | [
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pubmedcausal_25836 | This study provides robust genetic evidence supporting bidirectional causal relationships between PE-HTPs and specific plasma fatty acids, underscoring the critical role of fatty acid metabolism in maternal hypertensive disorders | [
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pubmedcausal_26959 | A significant causal association was found between serum uric acid levels and lung cancer in East Asian and European populations. Further sublayer analysis revealed a significant causal association between uric acid and small cell lung cancer, while no potential association was observed between uric acid and non-small ... | [
[
51,
73
],
[
78,
128
],
[
57,
66
],
[
220,
242
]
] |
pubmedcausal_7993 | We show that on average, subjects respond to an increase in the 'noise' of target motion by increasing sensory precision in their models of the target trajectory. In other words, they attend more to the sensory attributes of a noisier stimulus. Conversely, subjects only change kinetic parameters in their model but not ... | [
[
48,
88
],
[
346,
368
],
[
257,
329
]
] |
pubmedcausal_10521 | Vitamin D deficiency modestly increases the risk of AF. Further studies are needed to determine the if there is a direct causal relationship between vitamin D levels and AF and whether vitamin D supplements will prevent new-onset AF | [
[
0,
20
]
] |
pubmedcausal_20351 | We provide consistent evidence for the causal effect of genetic liability to depression on hypertension, which highlights the importance of blood pressure measurement and monitoring in patients with depression | [
[
56,
87
],
[
91,
103
]
] |
pubmedcausal_18109 | Both and general- and central obesity yield total causal effects on PCOS. Findings also indicated potential direct causal effects of normal weight-central obesity and more complex causal mechanisms when both central- and general obesity are present. Results underscore the importance of addressing both central- and gene... | [
[
221,
236
],
[
68,
72
],
[
22,
37
]
] |
pubmedcausal_24389 | Missingness is caused by an overlapping set of complex factors, including patients not identifying a need for an appointment or feeling it is 'for them'; appointments as sites of poor communication, power imbalance and relational threat; patients being exposed to competing demands, priorities and urgencies; issues of t... | [
[
28,
62
],
[
0,
11
]
] |
pubmedcausal_1280 | In this study stillbirth rate seems to be unacceptably high, though less than those reported in other settings. The causal factors associated with it were identified as nulliparity, unexplained intrauterine foetal deaths, hypertensive disease, and placenta abruptio. Because of the high rate of stillbirths reported in t... | [
[
282,
329
],
[
169,
180
],
[
182,
220
],
[
222,
242
]
] |
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