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pubmedcausal_28110 | Mechanical experiments on cadaveric thoracolumbar spine specimens showed that intervertebral disc degeneration was associated with reduced loading of the anterior vertebral body in upright postures. Reduced load bearing corresponded to locally reduced BMD and inferior trabecular architecture as measured by histomorphom... | [
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pubmedcausal_26585 | MR analysis revealed a causal relationship between the four metabolites and IBS, providing preliminary evidence for the pathogenesis of IBS. Our results provide novel insights into the potential biomarkers of IBS | [
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pubmedcausal_27257 | When estrogen levels drop, it will lead to a later age of menarche, and a later age of menarche may increase the risk of vaginitis, highlighting that the longer the female reproductive tract receives estrogen stimulation, the stronger the defense ability is formed, and the prevalence of vaginitis is reduced. In conclus... | [
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pubmedcausal_10211 | Low muscle mass estimated by low UCr was associated high baPWV in pre-dialysis CKD patients in Korea. Further studies are needed to confirm the causal relationship between UCR and baPWV, and the role of muscle mass in the development of cardiovascular disease in CKD | [
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pubmedcausal_4313 | Internet use increases BMI-for-age z-scores and overweight risks among adolescents, reinforcing the need for targeted interventions to mitigate its negative health impacts. Policies promoting healthier online behaviors and better access to nutritional education are essential to ensuring that adolescents develop healthy... | [
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pubmedcausal_7847 | Osteoarthritis pain has become a leading cause of decreased productivity and work disability in older workers, a major concern in primary care. How osteoarthritis pain leads to decreased productivity at work is unclear; the aim of this study was to elucidate causal mechanisms and thus identify potential opportunities f... | [
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pubmedcausal_29251 | The vast majority of global stillbirths occur in low- and middle-income countries, and in many settings, the majority of stillbirths occur antenatally, prior to the onset of labour. Poor nutritional status, lack of antenatal care and a number of behaviours increase women's risk of stillbirth in many resource-poor setti... | [
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pubmedcausal_29006 | Liver failure following liver surgery is caused by an insufficient functioning remnant cell mass. This can be due to insufficient liver volume and can be aggravated by additional cell death during or after surgery. The aim of this study was to elucidate the causes of hepatocellular injury in patients undergoing liver r... | [
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pubmedcausal_17078 | TMS-EEG measurements are sensitive to movement-induced changes in brain connectivity. These measurements may characterize clinically meaningful changes in circuit dynamics after stroke, thus providing specific targets for trials of TMS in post-stroke rehabilitation | [] |
pubmedcausal_22568 | Genetically proxied fresh fruit intake is causally associated with a reduced risk of the calculus of kidney and ureter | [
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pubmedcausal_5058 | The causal effects of gut microbiota on diverticulosis & diverticulitis was assessed using two-sample Mendelian randomization analysis. The sensitivity analyses were also performed. We then used integrative bioinformatics tools to identify core genes associated with diverticulitis and explore their potential mechanisms... | [
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pubmedcausal_21263 | Our study indicated a causal relationship between NER and EC that may be exploited in disease management | [
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pubmedcausal_7843 | Many common health conditions arise due to a combination of genetic factors and lifestyle-related behaviors. People's understanding of the multifactorial nature of health conditions has implications for their receptivity to health messages regarding genomics and medicine, and may be related to their adoption of protect... | [
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pubmedcausal_16531 | Biologics and ts-drugs can cause IGDs. These events are rare, and the causative effect of a specific drug is hard to establish. When a patient is suspected of having an IGD, the drug should be discontinued, and treatment for the new-onset renal disorder should be promptly started | [
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pubmedcausal_6185 | Elevated RC was linked to a greater risk of developing AAA, with MR analyses confirming a causal relationship. These findings suggest that RC may function as a new biomarker for AAA and could be integral to strategies aimed at preventing AAA | [
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pubmedcausal_9928 | In patients with clozapine-treated refractory schizophrenia, memantine addition significantly improved verbal and visual memory and negative symptoms without serious adverse effects. These results justify further investigations on long-term memantine augmentation to clozapine in treatment-resistant schizophrenia | [] |
pubmedcausal_5142 | Mendelian randomization analysis provides genetic evidence for causal relationships between kidney cancer and inflammatory factors, while excluding direct causal associations between kidney cancer and kidney fibrosis | [
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pubmedcausal_3398 | The causal relationship between cognitive impairment and functional decline seems bidirectional in older adults. This study aimed to determine the moderating effect of handgrip strength on the relationship between cognition and functional independence among Brazilian nonagenarians and centenarians | [
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pubmedcausal_10633 | The propensity score analysis shows that even the normal range of serum phosphorus clearly accelerates CKD progression to ESRD. Our results encourage clinicians to target serum phosphorus to inhibit CKD progression in the manner of 'the lower the better.' | [
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pubmedcausal_24353 | Insufficient sleep can increase the risk of health problems and chronic conditions including cognitive problems, increased inflammation, diabetes and cardiovascular disease, and overall mortality. In this report, insufficient sleep, as a cultural experience, was tracked across the United States according to the America... | [
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pubmedcausal_13482 | This MR analysis shows that high BP, especially SBP, is causally associated with poorer processing speed, verbal memory, and executive function during midlife. These findings emphasize the need for further investigation of the role and mechanisms of BP dysregulation on cognitive health in middle age and perhaps, more b... | [
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pubmedcausal_15077 | The findings highlight the need for regular intensive monitoring of ADRs in psychiatric outpatients by clinical pharmacists for early detection and reduction of risk caused by ADRs associated with antidepressants | [
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pubmedcausal_10166 | Ischemic stroke is a leading cause of death worldwide, despite preventive and therapeutic advances during the last twenty years. Blood-borne biomarkers have been studied in association to short- and long-term outcome, in order to investigate possible modifiable predictors of disability and death. Increased homocysteine... | [
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pubmedcausal_25079 | Our study confirms a causal relationship between dysbiosis of gut microbiota and the occurrence of CD and UC subtypes. Furthermore, it validates etiological distinctions among different subtypes of CD and UC. A novel approach to adjunctive therapy involving distinct UC or CD subtypes may involve the use of probiotics a... | [
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pubmedcausal_1456 | Dentists in the US see an increasing number of patients with systemic conditions. These patients are challenging to care for when the relationship between oral and systemic disease is not well understood. The prevalence of professional isolation exacerbates the problem due to the difficulty in finding expert advice or ... | [
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pubmedcausal_1290 | Despite the decades-long emphasis on withdrawal in leading models of addiction, the causal mechanisms driving smoking withdrawal effects are not well known. This gap in the knowledge base has stalled theory and treatment development for smoking dependence | [
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pubmedcausal_5244 | This study reveals a bidirectional causal connection between metabolic syndrome and ovarian dysfunction via genetic prediction methods. These findings are crucial for advancing our understanding of the interactions between these conditions and developing strategies for prevention and treatment | [
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pubmedcausal_8579 | Compared to medium consumption, both low and high alcohol consumption was associated with increased risk of sick leave. When low level drinkers were compared to medium level drinkers in a discordant twin design, the results were consistent with the association being due to genetic confounding rather than a causal effec... | [
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pubmedcausal_21440 | First, multiple assessment tools should be considered to increase objective assessment. Second, the cross-sectional design limited our ability to make causal inferences. Third, additional diabetes-related variables should be included to explore this relationship. Finally, the pathways of influence and mechanisms of act... | [
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pubmedcausal_26699 | Our study, through genetic means, demonstrates close causal associations between the specific types of immune cells and AD, PD, ALS and MS, providing useful guidance for future clinical researches | [
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pubmedcausal_14299 | The majority of presumptive TB patients attending a rural health facility did not submit sputum for testing, mainly due to the long travel distance to the laboratory. Bridging this gap in the diagnostic cascade may improve case detection | [
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pubmedcausal_1716 | Longitudinal analyses of repeat data suggest that health status improves after statutory and voluntarily retirement, although the improvement seems to attenuate over time. By contrast, the association between retirement due to ill health and subsequent poor health seems to reflect selection rather than causation | [
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pubmedcausal_4262 | Most introductions of the Alpha variant originated from France. As travel restrictions eased, the number of introductions from different countries increased. During the Delta and Omicron waves, the United Kingdom and Germany became important sources of the virus. The highest number of introductions occurred during the ... | [] |
pubmedcausal_26384 | The intricate relationship between migraine and insomnia has been a subject of great interest due to its complex mechanisms. Despite extensive research, understanding the causal link between these conditions remains a challenge | [
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pubmedcausal_26153 | The present findings reveal a causal relationship between obesity and the acceleration of epigenetic aging as well as the reduction of telomere length, offering valuable insights for further scientific investigations aimed at developing strategies to mitigate the aging process in humans | [
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pubmedcausal_701 | The provision of information that the overweight was the result of biological factors and of no causal information yielded more positive attitudes toward the overweight peer compared to those who were provided with environmental information. Information on overweight had no impact on behavioural intentions. A social de... | [
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pubmedcausal_22001 | This study is the first to demonstrate a case of human disease caused by a defect in centrosome reduction. We also uncovered a novel role for RTTN in perinatal cardiac development and identified a potential therapeutic strategy for centrosome-related iDCM. Future study aimed at identifying variants in centrosome compon... | [
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pubmedcausal_23610 | Patients with severe forms of EKC exhibited VD deficiency and higher levels of IgE. Increased TF inflammatory factors demonstrated a disease causal relationship with VD and IgE. Hence, restoring the altered levels of VD and IgE to normal range would be pivotal in the prevention and management of severe conjunctivitis | [
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pubmedcausal_11286 | The absence of teaching programs is a major issue in the lack of knowledge of health professionals regarding disaster preparedness. Thus, emergency and disaster preparedness has to be included in the primary medical school curricula and continuing medical education programs of the health facilities. Long-term formal tr... | [
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pubmedcausal_21098 | This study provides evidence that higher RC levels amplify frailty risk in middle-aged and older adults, implying that the reduction of RC levels may present a promising strategy for frailty prevention and management | [
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pubmedcausal_23675 | Our study demonstrates that MI promotes mammary tumor growth through the NGF-TRKA pathway. Consequently, inhibiting TRKA could represent a therapeutic strategy for breast cancer patients concurrently experiencing heart failure after MI | [
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pubmedcausal_11311 | The "straightforward" causality between oral health-related behavior and the actual OHS must be considered with caution, as well as their impact on the oral health-related quality of life. Further research is needed to investigate the interaction between variables, the strength of the interrelations and the magnitude o... | [
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pubmedcausal_25613 | The study revealed a significant causal association between genetically predicted JIA and POF, indicating that JIA significantly elevates the risk of developing POF. Therefore, it is recommended to implement screening for premature ovarian failure in women diagnosed with JIA | [
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pubmedcausal_26382 | This MR study revealed genetic evidence supporting a causal relationship between MDD and constipation | [
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pubmedcausal_28929 | Although conscripts accepted into military training pass physician-performed examinations as healthy, young adults, LBP hospitalisation causes significant morbidity during military service | [
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pubmedcausal_16376 | Undetermined etiology and DILI are the main causes of ALF in Brazil. However, APAP toxicity and DILI due to HDS are mostly uncommon | [
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pubmedcausal_18124 | In this study, we showed that the liability of gout has a causal effect on hypertension, but the liability of hypertension does not have a causal effect on gout. Adequate management of gout may reduce the risk of developing hypertension | [
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pubmedcausal_1824 | According to rodent models of postoperative cognitive decline, activation of the innate immune response following aseptic surgical trauma results in the elaboration of hippocampal proinflammatory cytokines, which are capable of disrupting long-term potentiation, the neurobiologic correlate of memory. The authors hypoth... | [
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pubmedcausal_27908 | Our MR analysis demonstrated a causal relationship between the gut microbiota and pain, highlighting its potential significance in advancing our understanding of the underlying mechanisms and clinical implications of microbiota-mediated pain | [
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pubmedcausal_5591 | This study contributes to existing knowledge by investigating the causal relationship between antibody-mediated immune responses and respiratory conditions, including COPD, asthma, and lung function, using a two-sample MR design. The key findings can aid in identifying individuals at risk of these conditions and facili... | [
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pubmedcausal_18947 | Thus, the conscious combination of less SMU and more physical activity leads causally to more psychological resilience against negative pandemic impacts and to higher levels of mental health over six months. Prevention programs could improve their effectiveness by integrating the time- and cost-efficient interventions ... | [
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pubmedcausal_24857 | The causal relationship between cathepsin and different subtypes of bipolar affective disorder was explored using bidirectional Mendelian randomization analysis and multivariate analysis | [
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pubmedcausal_29694 | As heat spells may occur in the future in an unpredictable way and because heat is not recognized as a health hazard in the North, more research should be devoted to clarifying the causal mechanisms underlying heat mortality, and pre-emptive measures should be planned | [
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pubmedcausal_8782 | Pain and depressive symptoms are associated in patients with dementia. Because reduced pain is associated with less depressive symptoms, these patients should be assessed regularly for untreated pain. The benefit of analgesic treatment should be weighed carefully against the potential for adverse effects | [
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pubmedcausal_8827 | Similar short-term treatment outcomes are achieved with RFA in HCC patients in the South-East Asian and Northern-European populations. Midterm recurrence and death rates differ between the groups as a result of differences in baseline patient characteristics and patient selection. Our study provides insight relevant to... | [
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pubmedcausal_26068 | FSG showed a linear and causal association with IHD, but not with stroke | [
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pubmedcausal_4914 | Our findings showed that genetically determined cigarette smoking, but not alcohol consumption, was causally associated with the risk of sarcopenia | [
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pubmedcausal_5290 | Blood donor release prior to donation by a physician is mandatory in Germany according to current guidelines. Due to shortage of qualified staff, the German Transfusion Act was modified allowing the use of telemedicine. The aim of the present study was to investigate the feasibility of remote plasma donor release with ... | [
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pubmedcausal_20865 | Critically ill children were frequently affected by hemodynamic alterations. The administration of drugs with potentially adverse effects on hemodynamic parameters is often temporally related to hemodynamic alterations. Hemodynamic alterations are often multifactorial, e.g., due to administering multiple drugs in rapid... | [
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pubmedcausal_20541 | Both our meta-analysis and MR study indicates that there is a causal relationship between the gut microbiome and PCOS, which may contribute to providing novel insights for the development of new preventive and therapeutic strategies for PCOS | [
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pubmedcausal_29868 | Based on these results, the relation between Helicobacter pylori and rosacea is supported, and infection should be investigated in these patients because an appreciable percentage of patients diagnosed with rosacea and Helicobacter pylori infection can benefit from eradication therapy, mainly in the papulopustular subt... | [
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pubmedcausal_8574 | Anxiety disorders, in particular Lifetime Anxiety Disorders, represent the only psychiatric disorder significantly associated with asthma, with a possible bidirectional, anxiety-asthma relationship, each of which can be caused or result from the other | [
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pubmedcausal_10055 | Statins are proposed as a chemoprevention agent for breast cancer due to their anti-inflammatory effect. The effects of lipophilic and hydrophilic statins on breast cancer risk might be different due to their different pharmacologic properties. Therefore, this study aimed to assess a casual-effect of lipophilic and hyd... | [
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pubmedcausal_14179 | Results from neuroimaging studies suggest that disruptions in flexible decision-making functions in substance-dependent individuals are a consequence of drug-induced neural adaptations. In addicted populations, however, the causal relationship between biobehavioral phenotypes of susceptibility and addiction consequence... | [
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pubmedcausal_17870 | A higher TyG index is an independent and causal risk factor for incident HF in the general population | [
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pubmedcausal_29037 | In the absence of clinical folate deficiency, periconceptional supplementation with folic acid reduces a woman's risk of having an infant with a neural-tube defect. Since antiserum to folate receptors induces embryo resorption and malformations in rats, we hypothesized that autoantibodies against folate receptors in wo... | [
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pubmedcausal_21659 | EAT thickness was correlated with inflammation and fibrosis-related circulating biomarkers, cardiac concentric change, myocardial strain impairment, incident HF risk, and overall CVD risk. NT-proBNP and GLS might partially mediate the effect of thickened EAT on the risk of HF. EAT could refine the assessment of CVD ris... | [
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pubmedcausal_16776 | Autoantibodies appear to increase CVD risk; however, the magnitude of the increase and the types of CVD outcomes affected are still unclear. Prospective studies with larger populations are required to further understand and quantify the association, including the causal pathway, between specific risk factors and CVD ou... | [
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pubmedcausal_26834 | By demonstrating a causal link between GM and NHL, this research offers novel ideas to prevent, monitor, and cure NHL later | [
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pubmedcausal_24409 | The association between diuretics and falls in older adult has been reported in previous studies, but discrepancy remains between the different types of diuretics. The association of diuretics with the risk of wrist fractures due to diuretics is also unclear. Therefore, in this study, we determined the association of d... | [
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pubmedcausal_18094 | Our findings reveal that there are beneficial or adverse causal effects of gut microbiome components on CVDs risk and provide novel insights into strategies for the prevention and management of CVDs through the gut microbiome | [
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pubmedcausal_1307 | This experimental model of induced hot flashes demonstrates a causal relationship between hot flashes and poor sleep quality. Objective hot flashes result in worse objective sleep efficiency, whereas subjective hot flashes worsen perceived sleep quality | [
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pubmedcausal_5528 | This study establishes a causal relationship between plasma metabolism and alopecia areata, enhancing our understanding of its underlying mechanisms. These findings also provide valuable references for future screening and prevention strategies | [
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pubmedcausal_17557 | Upward comparison resulted in negative effects for the participant compared to downward and neutral conditions, but downward comparison's impact was only found for human images. The described personality of the image had a more complex impact when using human images, but was still relevant for avatars | [
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pubmedcausal_20569 | All participants included in the GWAS were of European ancestry. Due to database limitations, the MR analysis did not conduct stratified analyses for different countries, ethnicities, or age groups | [
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pubmedcausal_26589 | Pneumonia and lung cancer are both major respiratory diseases, and observational studies have explored the association between their susceptibility. However, due to the presence of potential confounders and reverse causality, the comprehensive causal relationships between pneumonia and lung cancer require further explo... | [
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pubmedcausal_25162 | Our findings suggest that BMI may be considered a protective factor for BMD, while LDL may act as a risk factor. Moreover, LDL appears to play a mediatory role in the causal influence of BMI on BMD | [
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pubmedcausal_13336 | Our data showed that dermatologic examination and education of patients about skin cancer development and sunscreen measures improved the sun-protective habits of solid-organ transplant recipients. Therefore, orderly visits once or twice a year should be strongly advised for this patient population by their medical car... | [
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pubmedcausal_101 | Obesity and metabolic syndrome play causative roles in the increasing prevalence of proteinuria in the general population. However, in young adult women the clinical significance of incidentally discovered proteinuria and its association with metabolic syndrome are unclear. We investigated the prevalence and risk facto... | [
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pubmedcausal_18274 | Study findings proved constructing the causal relationships among personality traits, emotional status, learning strategies, and academic achievements of medical students, thus supporting our hypotheses. Early habits of self-regulated learning are essential for the successful academic achievements of medical students. ... | [
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pubmedcausal_20969 | This study demonstrates that IBD and its subtypes have a causal effect on HS, whereas HS does not affect IBD. Gut-skin axis interactions may help to understand this association. Nevertheless, further studies are needed to clarify the pathophysiology of the causal relationship between IBD and HS | [
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pubmedcausal_21656 | Enhanced management of multimorbidity constitutes a major clinical challenge. Multimorbidity shows well-established causal relationships with the high use of health care resources and, specifically, with unplanned hospital admissions. Enhanced patient stratification is vital for achieving effectiveness through personal... | [
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pubmedcausal_3343 | MR analysis revealed a causal relationship between PC species and FI. Specifically, | [
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pubmedcausal_29701 | Nectar of the two species was mostly sucrose-dominated, but composition varied widely in the field, ranging from sucrose-only to fructose-dominated. Most intra-specific variance was due to differences among nectaries of the same flower, and flowers of the same plant. The high intra-plant variation in sugar composition ... | [
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pubmedcausal_6401 | This past year of genomics research has led to multiple exciting findings involving genes and mechanisms linked to osteoarthritis. Moreover, the comprehensive genome-wide omics datasets generated for diverse osteoarthritis tissues will prove invaluable for future research aimed at elucidating more causal biological mec... | [
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pubmedcausal_5809 | The increased prevalence of physical diseases among individuals with mental illness contributes to their increased risk of mortality. However, the mediating role of specific diseases in the effect of mental illness on mortality is not well understood | [
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pubmedcausal_3026 | Eye care delay results reduced QoL and increased societal costs, yet this is compounded by gains attributable to justified prioritization of more urgent and more severe patients | [
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pubmedcausal_20917 | This MR analysis provides evidence of a causal association between cognitive impairment and CAD. Our findings highlight the importance of screening for coronary heart disease in patients of cognitive impairment, which might provide new insight into the prevention of CAD. Moreover, our study provides clues for risk fact... | [
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pubmedcausal_14729 | Our study provided a strong evidence that raised blood pressure in stroke patients increases the risk of atrial fibrillation and active acute blood pressure lowering can improve the outcome in ischemic stroke patients | [
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]
] |
pubmedcausal_29587 | These findings indicate that Sr accumulation in chronic renal failure rats resulted in the development of osteomalacic lesions, in contrast to the Al group where adynamic bone disease was induced in the present set-up. Further studies are required to define the mechanism by which way Sr causes osteomalacia in chronic r... | [
[
29,
74
],
[
87,
126
],
[
29,
31
],
[
295,
337
]
] |
pubmedcausal_27109 | Sepsis is a life-threatening organ dysfunction resulting from a dysregulated host response to infection, yet the potential causal relationship between the immunophenotype and sepsis remains unclear | [
[
64,
103
],
[
0,
6
]
] |
pubmedcausal_5853 | This study provides a genetic basis for the causal relationship between elevated iron status and increased arterial stiffness, suggesting the important role of micronutrients in the disease process | [
[
72,
92
],
[
97,
125
]
] |
pubmedcausal_151 | The use of a drug adherence monitoring program in the management of sHPT in hemodialysis patients receiving cinacalcet improves drug adherence and iPTH control and allows a reduction in the dose of cinacalcet | [
[
4,
118
],
[
119,
142
],
[
164,
208
]
] |
pubmedcausal_7689 | To review the incidence, microbiological profile, antibiogram, clinical course, treatment, and outcome in patients with microbial keratitis due to Aeromonas species at a tertiary eye care center in Southern India | [
[
147,
212
],
[
106,
139
]
] |
pubmedcausal_27807 | Mendelian randomization studies confirm the causal relationship between genetically predicted PN-related risk and genetically predicted plasma protein abundance. Plasma proteins, as biomarkers associated with PN, can provide potential drug targets for etiological intervention research in PN | [
[
114,
160
],
[
72,
109
],
[
162,
211
]
] |
pubmedcausal_18733 | This comprehensive explanation for the practice of indoor tanning provides the basis for development of complex interventions to reduce the harm caused by using sunbeds. Effective interventions should include promotion of alternatives, such as different methods of relaxing, to satisfy underlying motivations, changing s... | [
[
155,
168
],
[
140,
144
]
] |
pubmedcausal_17332 | Emotion regulation added both direct and indirect experimental explained variance over and above parenting alone. Clinical implications are discussed for the application of online training through pediatric settings | [
[
0,
18
]
] |
pubmedcausal_26711 | Elevated serum LDL-C increases the risk of LBD, while HDL-C and TG have no significant causal effects on LBD | [
[
0,
20
],
[
21,
46
]
] |
pubmedcausal_22837 | There is both a correlation and a causal relationship between frailty and osteoarthritis, and frailty may be a potentially better response than age to osteoarthritis | [
[
62,
69
],
[
74,
88
]
] |
pubmedcausal_12786 | Hyperthermia substantially increased infarct size in animal models of ischaemic stroke, suggesting that the relation between fever and poor outcome observed in patients is at least in part causal. These data provide support to trials testing the effect of the prevention of fever with antipyretic drugs in patients with ... | [
[
0,
12
],
[
27,
86
]
] |
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