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PPR:PPR1320864 | PPR1320864 | PPR | null | null | 10.64898/2026.09.09.750505 | Sex-dimorphic immune trajectories across the canine lifespan and early-life signatures of geroprotective interventions | Canine models are invaluable for translational geroscience, but widespread gonadectomy in companion dogs obscures natural sex-specific aging trajectories. Here, we characterize the age-associated hematologic and serum cytokine profiles of 80 intact laboratory Beagles spanning 1 to 11 years. Contrary to classical linear... | [
"Lai M",
"Xu F",
"Xu Y",
"Mironenkov A",
"Jin Y",
"Zhang S",
"Pan J",
"Li M",
"Deng B",
"Zhu J",
"Lyu Y"
] | Lai M, Xu F, Xu Y, Mironenkov A, Jin Y, Zhang S, Pan J, Li M, Deng B, Zhu J, Lyu Y. | null | 2,026 | 2026-09-15T00:00:00 | [
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PPR:PPR1320229 | PPR1320229 | PPR | null | null | 10.20944/preprints202609.1190.v1 | Longitudinal Changes in Redox-, Immune-, and Neuroendocrine-Related Biomarkers During Low-Intensity Multi-Frequency Bioelectronic Stimulation in Aged Dogs: An Exploratory Pilot Study | Aging is associated with chronic low-grade inflammation, redox imbalance, and altered neuroendocrine regulation. This exploratory pilot study evaluated the feasibility, safety, and longitudinal biomarker changes observed during low-intensity multi-frequency bioelectronic stimulation in six clinically healthy aged dogs ... | [
"Yoo E",
"Choi Y",
"You E"
] | Yoo E, Choi Y, You E. | null | 2,026 | 2026-09-15T00:00:00 | [
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PPR:PPR1301854 | PPR1301854 | PPR | null | null | 10.21203/rs.3.rs-10652184/v1 | Title page: Pharmacokinetics of Cefovecin (Convenia®) After 8 mg/kg Intramuscular Administration in Bottlenose Dolphins (Tursiops truncatus): Age-Related Differences | <title>Abstract</title> <p> · <bold>Background:</bold> Cefovecin is a third-generation cephalosporin approved for use in dogs and cats, characterized by an exceptionally long elimination half-life that in these species allows for a 14-day dosing interval. This pharmacological profile makes it particularly attractiv... | [
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"Morón-Elorza P",
"Rojo-Solís C",
"Álvaro T",
"Valls M",
"Gilabert JA",
"García-Párraga D"
] | Encinas T, Morón-Elorza P, Rojo-Solís C, Álvaro T, Valls M, Gilabert JA, García-Párraga D. | null | 2,026 | 2026-08-20T00:00:00 | [
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PPR:PPR1286822 | PPR1286822 | PPR | null | null | 10.20944/preprints202607.1962.v1 | Magnetic Resonance Imaging as a Diagnostic Marker of CCD: A Review | Alzheimer’s disease (AD) in humans shares several features with canine cognitive dysfunction (CCD), a disease that affects older dogs. Therefore, CCD serves as a natural model for the study of AD. Several studies have documented early pathological changes in both AD and CCD, including widespread damage to the cerebral ... | [
"Garcia MSA",
"Anaya JSH",
"Santoscoy Mejia EC",
"Mendez Aguilar RE"
] | Garcia MSA, Anaya JSH, Santoscoy Mejia EC, Mendez Aguilar RE. | null | 2,026 | 2026-07-28T00:00:00 | [
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PPR:PPR1279057 | PPR1279057 | PPR | null | null | 10.64898/2026.07.11.737944 | A canine brain bank for comparative neuroscience and brain aging research | Companion animal brain banking has been recognized as a valuable approach for translational aging and dementia research. However, realizing the full value of canine brain banks depends on optimizing the methods that are used to collect and preserve the tissue. Whole brain perfusion fixation is one promising approach, b... | [
"Darcy S",
"Beck A",
"Garrood M",
"Slaughter A",
"Parra A",
"Paredes L",
"Farrell K",
"Crary JF",
"McKenzie AT"
] | Darcy S, Beck A, Garrood M, Slaughter A, Parra A, Paredes L, Farrell K, Crary JF, McKenzie AT. | null | 2,026 | 2026-07-14T00:00:00 | [
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PPR:PPR1245910 | PPR1245910 | PPR | null | null | 10.64898/2026.06.03.729926 | An interpretable machine learning framework for dog breed inference and ancestry decomposition | The over 300 currently recognized breeds of domesticated dogs are the culmination of centuries of intense artificial selection and recurrent population bottlenecks. While breed labels are widely used in genetic and veterinary studies, inferring breed identity from genomic data remains challenging due to the high dimens... | [
"Bian Y",
"Bierman R",
"Snyder-Mackler N",
"Promislow D",
"Karlsson E",
"",
"Akey JM"
] | Bian Y, Bierman R, Snyder-Mackler N, Promislow D, Karlsson E, Dog Aging Project Consortium, Akey JM. | null | 2,026 | 2026-06-04T00:00:00 | [
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PPR:PPR1244197 | PPR1244197 | PPR | null | null | 10.64898/2026.06.01.729193 | NECAP antagonizes light-induced Rhodopsin-1 internalization to promote photoreceptor homeostasis | AP-2 is a key mediator of clathrin-mediated endocytosis (CME) that internalizes cargo from the plasma membrane. NECAP proteins physically bind phosphorylated AP-2 during CME, but their roles during endocytosis remain unresolved, with conflicting reports about their function. Here, we report that Drosophila NECAP is di... | [
"Huang H",
"Tyrlik M",
"Huang P",
"Yeo AI",
"Kim A",
"Perrimon N",
"Tseng C",
"Bellen HJ",
"Ryoo HD"
] | Huang H, Tyrlik M, Huang P, Yeo AI, Kim A, Perrimon N, Tseng C, Bellen HJ, Ryoo HD. | null | 2,026 | 2026-06-02T00:00:00 | [
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PPR:PPR1224166 | PPR1224166 | PPR | null | null | 10.64898/2026.02.10.705136 | Thermodynamic scaling of canine aging and reversible clock deceleration by a reverse transcriptase inhibitor | Aging was tracked in a cohort of 99 “retired” sled dogs over four years to characterize the latent dynamics of physiological decline. Animals were randomized to receive either placebo or the reverse transcriptase inhibitor lamivudine for ∼30 months. We employed a variational autoregressive model to integrate longitudin... | [
"Matrenok S",
"Andrianova EL",
"Avchaciov K",
"Fleyshman DI",
"Huson HJ",
"Loftus JP",
"Wakshlag JJ",
"Zhang B",
"Gladyshev VN",
"Gudkov AV",
"Fedichev PO"
] | Matrenok S, Andrianova EL, Avchaciov K, Fleyshman DI, Huson HJ, Loftus JP, Wakshlag JJ, Zhang B, Gladyshev VN, Gudkov AV, Fedichev PO. | null | 2,026 | 2026-02-12T00:00:00 | [
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PPR:PPR1222924 | PPR1222924 | PPR | null | null | 10.64898/2026.02.19.706838 | Beyond dual hubs: Task and aging shape taxonomic and thematic semantic relationships in the human brain | Semantic knowledge about concepts and their relationships is central to human cognition. Taxonomic relationships link concepts belonging to the same category (e.g. dog and bear ), while thematic relationships connect concepts co-occurring in the same events (e.g. dog and leash ). The dual-hub theory proposes that t... | [
"Kuhnke P",
"Martin S",
"Chapman CA",
"Hartwigsen G"
] | Kuhnke P, Martin S, Chapman CA, Hartwigsen G. | null | 2,026 | 2026-02-20T00:00:00 | [
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PPR:PPR1217675 | PPR1217675 | PPR | null | null | 10.64898/2026.03.07.710297 | Blood biomarkers and breed genetics of aging in pet dogs | Pet dogs share human-like environments while aging on a compressed timescale, making them a powerful translational model for aging research. Using genomic and phenotypic data from 7,627 dogs in the Dog Aging Project, including 976 profiled for 159 blood metabolites and clinical analytes, we generated the first GWAS cat... | [
"Sohrab V",
"White ME",
"Harrison BR",
"Bierman R",
"Marye A",
"Morrill Pirovich K",
"Genereux DP",
"Megquier K",
"Li X",
"Kenney B",
"Reichel C",
"",
"Snyder-Mackler N",
"Akey JM",
"Promislow DEL",
"Chen FL",
"Karlsson EK"
] | Sohrab V, White ME, Harrison BR, Bierman R, Marye A, Morrill Pirovich K, Genereux DP, Megquier K, Li X, Kenney B, Reichel C, Dog Aging Project Consortium, Snyder-Mackler N, Akey JM, Promislow DEL, Chen FL, Karlsson EK. | null | 2,026 | 2026-03-10T00:00:00 | [
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PPR:PPR1214553 | PPR1214553 | PPR | null | null | 10.64898/2026.04.14.718346 | Stem Cell Divisions, Driver Mutations, and Carcinogenesis in Purebred Dogs | Most cancers are initiated by mutations that inactivate tumour-suppressor genes or activate oncogenes. Fitting a multistage model of carcinogenesis to the increase in cancer mortality with breed-specific size and lifespan in dogs has predicted that four somatic driver mutations are typically required to initiate cancer... | [
"da Silva J"
] | da Silva J. | null | 2,026 | 2026-04-17T00:00:00 | [
"Preprint"
] | null | [] | [] | [] | false | false | false | false | null | 0 | [
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PPR:PPR1182742 | PPR1182742 | PPR | null | null | 10.21203/rs.3.rs-9360671/v1 | Cognitive Assessment for Neuropsychological Impairments in Dogs (CANID): An Efficient, Repeatable, and Sensitive Evaluation for Age-related Cognitive Dysfunction | <title>Abstract</title> <p>We introduce the Cognitive Assessment for Neuropsychological Impairments in Dogs (CANID), a functional evaluation consisting of three cognitive tasks that measure aspects of memory and executive function. CANID can be implemented in a single ~ 40-minute evaluation, was designed for studies o... | [
"Hargrave SH",
"Bray EE",
"Switzer LR",
"McGrath S",
"Alexander GE",
"Block T",
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"Chao N",
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"Hilyard E",
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"Kennedy BS",
"Kristal E",
"Moreno JA",
"Promislow DEL",
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PPR:PPR1177788 | PPR1177788 | PPR | null | null | 10.20944/preprints202604.0902.v1 | Clinical Course of Severe Perineal Hypospadias with Cryptorchid Testicular Tumors in a Dog: Contextual Reference to Developmental and Endocrine Transcriptomic Pathways | Hypospadias is a congenital malformation of the male external genitalia resulting from incomplete fusion of the urethral folds during embryonic development. The perineal form represents the most severe phenotype and is frequently associated with abnormalities such as cryptorchidism and penile hypoplasia. Although surgi... | [
"Lee N",
"Kwon K",
"Oh A",
"Choi K"
] | Lee N, Kwon K, Oh A, Choi K. | null | 2,026 | 2026-04-14T00:00:00 | [
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PPR:PPR1165397 | PPR1165397 | PPR | null | null | 10.21203/rs.3.rs-8918755/v1 | Senior Dogs have Less Plasma Circulating Exosomes Than Young Dogs, With Altered Sterol and miRNA content | <title>Abstract</title> <p>Increasing life expectancy has been accompanied by a higher prevalence of age-associated conditions, underscoring the need to better understand biological mechanisms of aging and to identify accessible biomarkers. Extracellular vesicles (EVs) are lipid-bilayer vesicles that mediate intercell... | [
"Marina CL",
"Greuel AM",
"Las-Casas LdO",
"Lopes E",
"Ferrari SSdAR",
"Rodrigues ML",
"Reis FCGd",
"Bocca AL",
"Titze-de-Almeida SS",
"Resende FFB",
"de Sant’Anna FJ",
"Titze-de-Almeida R"
] | Marina CL, Greuel AM, Las-Casas LdO, Lopes E, Ferrari SSdAR, Rodrigues ML, Reis FCGd, Bocca AL, Titze-de-Almeida SS, Resende FFB, de Sant’Anna FJ, Titze-de-Almeida R. | null | 2,026 | 2026-03-13T00:00:00 | [
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PPR:PPR1161338 | PPR1161338 | PPR | null | null | 10.21203/rs.3.rs-8994620/v1 | Alzheimer’s Disease Neuropathological characterization of the dog brain and relationship to biofluid biomarkers and cognitive function | <title>Abstract</title> <p>Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and a major global health challenge affecting more than 55 million people worldwide. AD is clinically defined by progressive cognitive decline and neuropathologically characterized by the accumulation of amyloid... | [
"Alsulami A",
"Bogdani M",
"MacLean E",
"Keene CD",
"McGrath S",
"",
"Latimer CS",
"Moreno JA"
] | Alsulami A, Bogdani M, MacLean E, Keene CD, McGrath S, Dog Aging Project Consortium, Latimer CS, Moreno JA. | null | 2,026 | 2026-03-03T00:00:00 | [
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PPR:PPR1160523 | PPR1160523 | PPR | null | null | 10.31234/osf.io/qwb6h_v3 | Rethinking Delay of Gratification: Developmental Changes in Self-Regulation Across Five Countries | <p>The ability to delay gratification (DoG) is widely regarded as a hallmark of self-regulation and has been linked to positive developmental and health outcomes. It remains unclear whether age-related improvements in DoG reflect delay-specific control processes or broader developmental changes in children’s regulation... | [
"Zupan Z",
"Gao Z",
"Ranc P",
"Pascu DS",
"Lorenzato L",
"Machado A",
"Oberschulte J"
] | Zupan Z, Gao Z, Ranc P, Pascu DS, Lorenzato L, Machado A, Oberschulte J. | null | 2,026 | 2026-02-28T00:00:00 | [
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PPR:PPR1158262 | PPR1158262 | PPR | null | null | 10.21203/rs.3.rs-8895010/v1 | Pilot study on calculus removal from orthodontic retainers using different mechanical approaches: an in-vitro investigation of the adhesive strength of fixed retainers | <title>Abstract</title> <p> <bold>Introduction</bold> Orthodontic fixed retainers are often a predilection site for calculus build-up. However, standardized protocol for professional mechanical plaque removal (PMPR) does not yet exist that takes into account the slight weakening of the adhesive bond. <bold>Material... | [
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"Pfaff MS",
"Erber R",
"Roser CJ",
"Awounvo S",
"Zenthöfer A",
"Lux CJ",
"Bartha V"
] | Heberer M, Pfaff MS, Erber R, Roser CJ, Awounvo S, Zenthöfer A, Lux CJ, Bartha V. | null | 2,026 | 2026-02-24T00:00:00 | [
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MED:42816925 | 42816925 | MED | 42816925 | null | 10.1177/13872877261491819 | Clinical and neuropathological aspects of canine cognitive dysfunction syndrome and a translational perspective for Alzheimer's disease. | Canine cognitive dysfunction syndrome (CCDS) shares notable clinical and molecular similarities with Alzheimer's disease (AD), supporting the value of cross-species translational research to enhance diagnostic and therapeutic approaches for both conditions. These disorders are progressive neurological diseases characte... | [
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"Greuel AM",
"Marina CL",
"de Sant'Ana FJF",
"Titze-de-Almeida SS",
"Titze-de-Almeida R"
] | Lopes-Gomes E, Resende FFB, Greuel AM, Marina CL, de Sant'Ana FJF, Titze-de-Almeida SS, Titze-de-Almeida R. | Journal of Alzheimer's disease : JAD | 2,026 | 2026-09-30T00:00:00 | [
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MED:42816321 | 42816321 | MED | 42816321 | null | 10.1292/jvms.26-0189 | Age distribution and regression-associated immunophenotypic features in canine cutaneous histiocytoma. | Canine cutaneous histiocytoma (CCH) is a benign tumor characterized by spontaneous immune-mediated regression. Although common in young dogs, it also occurs in older animals. This retrospective study evaluated histologic and immunohistochemical features of CCH across age groups, focusing on mitotic count, lymphocytic i... | [
"Chen YM",
"Liao ZW",
"Kuo CL",
"Kuo CC",
"Huang WH"
] | Chen YM, Liao ZW, Kuo CL, Kuo CC, Huang WH. | The Journal of veterinary medical science | 2,026 | 2026-10-01T00:00:00 | [
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MED:42808498 | 42808498 | MED | 42808498 | null | 10.1177/13872877261487575 | Aging dogs exhibit heterogeneous cognitive decline trajectories: A longitudinal comparative model. | BackgroundBoth dogs and humans experience substantially variable cognitive decline with age. In humans, this ranges from healthy cognitive aging to early onset Alzheimer's disease. While different rates of cognitive decline have been described in purpose-bred beagles, few studies have examined longitudinal trajectories... | [
"Simon KE",
"Panek WK",
"Fefer G",
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MED:42806282 | 42806282 | MED | 42806282 | PMC13619339 | 10.1093/jvimsj/aalag208 | The relationship between urinalysis abnormalities, soiling behavior, and cognitive decline in aging dogs. | <h4>Background</h4>In elderly people, dementia and urinary tract dysfunction often exacerbate one another. Aging dogs also suffer cognitive decline but the relationship between cognitive decline, soiling behaviors, and urinalysis abnormalities has not been explored.<h4>Hypothesis/objectives</h4>Soiling behavior is asso... | [
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MED:42798654 | 42798654 | MED | 42798654 | PMC13612547 | 10.3389/fvets.2026.1776920 | A neurotrophic withdrawal hypothesis for multisystem adverse events associated with anti-NGF therapy for canine osteoarthritis pain. | Post-marketing reports in dogs treated with <i>bedinvetmab</i> (Librela™, Zoetis), the first anti-nerve growth factor (NGF) monoclonal antibody approved for canine osteoarthritis pain, include musculoskeletal, autonomic, and neurological events. Existing interpretations address these domains separately or focus on the ... | [
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"Elia V",
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] | Federico G, Ilardi A, Elia V, Chieffi S. | Frontiers in veterinary science | 2,026 | 2026-09-11T00:00:00 | [
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MED:42798481 | 42798481 | MED | 42798481 | PMC13612525 | 10.3389/fpubh.2026.1916258 | Temporal changes in allergen-specific IgE sensitization patterns in Xiamen, 2019-2023: a retrospective cross-sectional analysis. | <h4>Background</h4>The COVID-19 pandemic has induced substantial changes in environment, lifestyle, and health behaviors. We observed temporal associations between the pandemic period and declining sIgE positivity rates; however, causality cannot be established due to the retrospective observational design. Distinguish... | [
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"Geng J",
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MED:42797917 | 42797917 | MED | 42797917 | PMC13611981 | 10.3390/vetsci13090881 | Serum Cystatin C and the Urinary NAG Index Identify an Altered Renal Biochemical Phenotype in Clinically Healthy Geriatric Dogs with Normal Serum Creatinine: A Three-Tier Cross-Sectional Study. | Serum creatinine (sCr), blood urea nitrogen (BUN) and symmetric dimethylarginine (SDMA) reflect glomerular filtration only and are subject to non-renal confounders including lean body mass, limiting early detection of renal dysfunction in geriatric dogs. We evaluated serum cystatin C (sCysC) and the urinary N-acetyl-β-... | [
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"Biriș A",
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"Haşaş AD",
"Popovici C",
"Ursache AL",
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MED:42784859 | 42784859 | MED | 42784859 | null | 10.1016/j.cortex.2026.09.006 | Beyond dual hubs: Task and aging shape taxonomic and thematic semantic relationships in the human brain. | Semantic knowledge about concepts and their relationships is central to human cognition. Taxonomic relationships link concepts belonging to the same category (e.g. dog and bear), while thematic relationships connect concepts co-occurring in the same events (e.g. dog and leash). The dual-hub theory proposes that taxonom... | [
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"Martin S",
"Chapman CA",
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] | Kuhnke P, Martin S, Chapman CA, Hartwigsen G. | Cortex; a journal devoted to the study of the nervous system and behavior | 2,026 | 2026-09-10T00:00:00 | [
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MED:42778365 | 42778365 | MED | 42778365 | null | 10.1292/jvms.26-0252 | Computational prescreening of anticancer drugs prior to in vitro validation, primarily in dogs with exploratory cat data, based on cross-species binding conservation. | Advances in veterinary medicine have prolonged the lifespan of companion animals. As a result, the burden of neoplastic diseases has increased. While targeted anticancer drugs are widely used in human oncology, their clinical translation to companion animals remains limited. Therefore, a systematic framework for priori... | [
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"Park JK",
"Jang S",
"Kim C",
"Park S",
"Han JE",
"Kim W",
"Han S",
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] | Lee SW, Kim HY, Choi SK, Lim SG, Ko J, Park J, Baek SM, Park JK, Jang S, Kim C, Park S, Han JE, Kim W, Han S, Kim S. | The Journal of veterinary medical science | 2,026 | 2026-09-22T00:00:00 | [
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MED:42774025 | 42774025 | MED | 42774025 | PMC13593421 | 10.3389/fimmu.2026.1906638 | Multiomic profiling of canine immune and metabolic aging in a cohort of young and senior beagles. | <h4>Introduction</h4>Developing a comprehensive understanding of canine aging requires integration of immune, metabolic, and genetic changes across molecular layers. While high-throughput omics have been widely applied to human aging, canine studies have typically used single modalities or small cohorts, limiting syste... | [
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] | Abood A, Louyakis AS, Jackson M, Eichman R, Hollar R, Panickar KS, Brockman J. | Frontiers in immunology | 2,026 | 2026-09-08T00:00:00 | [
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MED:42766958 | 42766958 | MED | 42766958 | null | 10.1016/j.prevetmed.2026.107021 | Multimorbidity, behaviour and QoL in ageing dogs. | Older dogs frequently develop multiple chronic conditions, accompanied by behavioural and functional changes that may adversely affect their quality of life (QoL). However, the relative contributions of multimorbidity, behavioural manifestations, and functional performance to owner-perceived QoL remain incompletely und... | [
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"Kottferová L",
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"Mezníková S",
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] | Kottferová J, Vajányi D, Kottferová L, Florian M, Mezníková S, Skurková L. | Preventive veterinary medicine | 2,026 | 2026-09-18T00:00:00 | [
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MED:42762824 | 42762824 | MED | 42762824 | null | 10.2460/javma.26.06.0467 | Eight-week postoperative tibial plateau leveling osteotomy radiographs do not change the prescribed management plan for most dogs. | <h4>Objective</h4>To determine how frequently routine 8-week tibial plateau leveling osteotomy (TPLO) radiographs resulted in a change to the prescribed postoperative management plan when evaluated by surgery residents versus senior clinicians, and how often the resident and senior clinician plans differed.<h4>Methods<... | [
"Hancock CL",
"Frederick SW",
"Israel SK"
] | Hancock CL, Frederick SW, Israel SK. | Journal of the American Veterinary Medical Association | 2,026 | 2026-09-18T00:00:00 | [
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MED:42760573 | 42760573 | MED | 42760573 | PMC13587325 | 10.1186/s40575-026-00158-1 | Pedigree structure, inbreeding, and survival analysis in an Irish Wolfhound cohort. | <h4>Background</h4>The Irish Wolfhound (IW) is a giant dog breed characterized by a relatively short lifespan, a high prevalence of heritable disorders, and extensive relatedness among lineages. Despite the recognized importance of inbreeding and population structure in purebred dogs, relatively little is known about h... | [
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"Bernini F",
"Marelli SP",
"Poli M",
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] | Ferrari C, Bernini F, Marelli SP, Poli M, Strillacci MG. | Companion animal health and genetics | 2,026 | 2026-09-18T00:00:00 | [
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MED:42753031 | 42753031 | MED | 42753031 | null | 10.1007/s11357-026-02533-z | Integration of methylome and transcriptome reveals age-associated signatures of stage-specific dynamics and regulatory remodeling in dogs. | Aging in mammals is characterized by widespread yet coordinated epigenetic alterations. However, integrative analyses of DNA methylation and gene expression in dogs remain largely unexplored, particularly within genetically homogeneous single-breed populations. To elucidate the molecular signatures of canine aging, we ... | [
"Kang D",
"Bok EY",
"Hong CY",
"Plassais J",
"Choe YH",
"Lee SL",
"Kim J"
] | Kang D, Bok EY, Hong CY, Plassais J, Choe YH, Lee SL, Kim J. | GeroScience | 2,026 | 2026-09-17T00:00:00 | [
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MED:42751990 | 42751990 | MED | 42751990 | null | 10.1111/jsap.70198 | Age-dependent expression and heritability of owner-reported dermatological symptoms in Labrador retrievers: Implications for breeding strategies. | <h4>Objectives</h4>In decentralised breeding programmes, consistent health monitoring can be challenging, yet accurate phenotyping is essential for informed selection. This study evaluated whether a concise owner-based online survey could capture clinically relevant dermatologic signs in a Belgian assistance-dog breedi... | [
"Deboutte B",
"Lambrecht L",
"Broeckx BJG"
] | Deboutte B, Lambrecht L, Broeckx BJG. | The Journal of small animal practice | 2,026 | 2026-09-17T00:00:00 | [
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MED:42749338 | 42749338 | MED | 42749338 | PMC13581454 | 10.1002/vms3.71213 | Multiple Modelling Methods Suggest That Grain-Free Diets Are Not Predictive of New Owner-Reported Cardiac Diagnoses Over Two Years in the Dog Aging Project, Despite Owner Misclassification of Diet. | <h4>Background</h4>Grain-free diets have been potentially linked to dilated cardiomyopathy (DCM) in several studies in dogs, although the underlying mechanisms for this potential link, if present, are unclear. Additionally, some studies have found no association between grain-free diets and DCM in dogs. Unfortunately, ... | [
"O'Brien J",
"Bishop M",
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"Tolbert MK",
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MED:42748828 | 42748828 | MED | 42748828 | null | 10.1016/j.biopha.2026.119934 | Non-clinical safety evaluation of coenzyme I (NAD⁺): A GLP-compliant systematic study. | Nicotinamide adenine dinucleotide (NAD⁺) is a core coenzyme in cellular energy metabolism and redox homeostasis, with pharmacological effects in cardiovascular and neurodegenerative diseases and in aging. Its non-clinical safety was evaluated through GLP-compliant studies that included safety pharmacology (single intra... | [
"Gu J",
"Xu J",
"Yang S",
"Qiu Y",
"Yin L",
"Xu N"
] | Gu J, Xu J, Yang S, Qiu Y, Yin L, Xu N. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 2,026 | 2026-09-16T00:00:00 | [
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MED:42743987 | 42743987 | MED | 42743987 | null | 10.2460/ajvr.26.03.0102 | Cardiac pacemakers in dogs: programming parameters. | <h4>Objective</h4>To report the behavior of the main parameters used in the evaluation of cardiac pacemakers (PMs) in dogs, associated complications, and survival times.<h4>Methods</h4>This retrospective cohort study evaluated dogs that received PMs (from 2016 through 2023) at a veterinary teaching hospital. Dogs of va... | [
"Oyafuso MK",
"Triches Dornbusch P",
"Moreno JCD",
"Hamamura C",
"Sousa MG"
] | Oyafuso MK, Triches Dornbusch P, Moreno JCD, Hamamura C, Sousa MG. | American journal of veterinary research | 2,026 | 2026-09-15T00:00:00 | [
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MED:42742206 | 42742206 | MED | 42742206 | null | 10.1128/mbio.01951-26 | The canine gut microbiome as a translational model for human health and aging. | The domestic dog is increasingly recognized as a complementary translational model for microbiome research relevant to human health while also offering direct benefits for veterinary medicine. Dogs share environments and dietary exposures with humans and show substantial taxonomic and gene-content similarity to the hum... | [
"Boldogkői Z",
"Tombácz D"
] | Boldogkői Z, Tombácz D. | mBio | 2,026 | 2026-09-15T00:00:00 | [
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MED:42738524 | 42738524 | MED | 42738524 | PMC13565028 | 10.3390/ani16172737 | Concurrent Multidomain Cognitive Assessment and Serum BDNF Level in Aged Dogs: Comparison Between Normal Cognition and Mild Cognitive Impairment. | Early detection of canine cognitive dysfunction syndrome (CDS) is challenged by the limitations of single diagnostic tools, including owner-reported subjectivity and impractical behavioral testing protocols. This study examined a multidomain strategy integrating questionnaires, behavioral testing, and a circulating bio... | [
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MED:42738448 | 42738448 | MED | 42738448 | PMC13564329 | 10.3390/ani16172659 | Investigation of Serum Neurofilament Light Chain as a Surrogate for Cerebrospinal Fluid Neurofilament Light Chain in Canine Cognitive Dysfunction Syndrome. | The serum neurofilament light chain (NfL) is a promising circulating biomarker for canine cognitive dysfunction syndrome (CCDS). This cross-sectional study evaluated serum NfL (sNfL) as a surrogate for cerebrospinal fluid NfL (cNfL) and assessed the effects of physiological factors on its clinical utility. Biofluid NfL... | [
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MED:42733759 | 42733759 | MED | 42733759 | PMC13571938 | 10.1016/j.lansea.2026.100854 | Pre-exposure prophylaxis as a complementary vaccination strategy to reduce rabies in Kerala, India: a cost-effectiveness modelling study. | <h4>Background</h4>Post-exposure prophylaxis (PEP) and dog vaccination continue to be the widely adopted vaccination strategy for rabies control in high-burden countries like India. To determine the public health and economic impacts of childhood pre-exposure prophylaxis (PrEP) relative to existing strategies, we carri... | [
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MED:42728580 | 42728580 | MED | 42728580 | null | 10.1177/1098612x261491120 | EXPRESS: What Goes in the Bowl? Evidence-Based Nutrition for Ageing Domestic Cats. | With the increasing life expectancy of domestic cats, there is a growing imperative to understand and address the unique nutritional needs of senior felines. This review critically examines current knowledge regarding the physiological changes associated with feline ageing, the nutritional requirements of older cats, a... | [
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MED:42721562 | 42721562 | MED | 42721562 | null | 10.1016/j.vetpar.2026.110922 | A nationwide epidemiological update on respiratory and intestinal nematodes in at-risk dogs in Italy. | This study updates current information on the occurrence of Capillaria aerophila, Capillaria boehmi and Angiostrongylus vasorum infections in dogs from Italy, along with the evaluation of the occurrence of intestinal parasites. Fecal samples collected from a total of 2000 dogs living in the majority of the Italian regi... | [
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MED:42718794 | 42718794 | MED | 42718794 | PMC13553473 | 10.3389/fvets.2026.1898326 | Image based three-dimensional kinematic mapping to optimize femoral tunnel placement for intra-articular cranial cruciate ligament reconstruction in dogs. | <h4>Objective</h4>The development of synthetic ligaments (SLs) has sparked renewed interest in intra-articular cranial cruciate ligament (CrCL) reconstruction. In this procedure, minimizing changes in graft length through optimal tunnel placement is essential for long-term function. However, three-dimensional (3D) asse... | [
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MED:42713254 | 42713254 | MED | 42713254 | PMC13552685 | 10.12788/fp.0671 | Whole Health(y) Aging With Gerofit: The Development of a Pilot Wellness Program for Older Veterans. | <h4>Background</h4>The Veterans Health Administration (VHA) serves > 9 million veterans, half of whom are aged ≥ 65 years. Veterans are at higher risk for comorbidities, including obesity and related chronic diseases, which contribute to increased health care costs, mobility disability, poor quality of life, and mortal... | [
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MED:42706237 | 42706237 | MED | 42706237 | PMC13550594 | 10.1038/s41413-026-00581-x | Single-cell multi-omics defines H3K27me3 remodelling in intervertebral disc degeneration with implications for regenerative intervention. | Utilizing key developmental cues and refining their orchestrating role in degeneration represents a promising strategy for understanding and treating intervertebral disc (IVD) degeneration, a major cause of chronic lower back pain. Here, we focus on notochordal cells (NCs), which originate from the embryonic notochord ... | [
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MED:42692161 | 42692161 | MED | 42692161 | null | 10.1016/j.bbabio.2026.149605 | Effects of increases in temperature and genipin on mitochondrial function in primary fibroblast cells of dogs of different sizes and ages. | In homeotherms, heat loss and the need for heat production are increased in small animals compared with large ones, and mitochondria are the primary organelles responsible for heat production in animals. Because of this, in animals of different body sizes, mitochondria may differ in their sensitivity to temperature and... | [
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MED:42689384 | 42689384 | MED | 42689384 | PMC13539535 | 10.1002/vms3.71187 | Severe Hypernatraemia Secondary to Adipsia Associated With a Pituitary Macroadenoma in a Dog: A Case Report. | <h4>Background</h4>Adipsia is a rare disorder characterised by absence of thirst despite hyperosmolality, resulting from dysfunction of the hypothalamic thirst centre. In veterinary medicine, most reported cases of adipsia are associated with congenital forebrain abnormalities, whereas acquired causes in adult dogs are... | [
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MED:42688807 | 42688807 | MED | 42688807 | PMC13535678 | 10.30476/dentjods.2025.107027.2711 | <i>In vitro</i> Evaluation of the Remineralizing Potential and Color Change of Modified Fluoride Varnish with Polyvinylpyrrolidone-Coated Silver Nanoparticles on Incipient Enamel Lesions in Primary Teeth. | <h4>Background</h4>Dental caries is closely associated with biofilms and characterized by cycles of demineralization and remineralization that weaken tooth structure over time. Given the need for effective prevention and enhanced remineralization, developing a more esthetic and efficient approach is essential in improv... | [
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MED:42687149 | 42687149 | MED | 42687149 | PMC13540077 | 10.1186/s12877-026-08157-4 | A mixed-methods feasibility study of dog-assisted exercise therapy in geriatric inpatients. | <h4>Background</h4>Animal-assisted therapy (AAT) is a promising complementary approach in geriatric rehabilitation, but evidence on feasibility and patient experiences remains limited.<h4>Methods</h4>This exploratory, mixed-methods, two-arm randomized controlled parallel-group design (RCT) compared dog-assisted exercis... | [
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MED:42655785 | 42655785 | MED | 42655785 | PMC13517765 | 10.3390/vetsci13080765 | Eicosapentaenoic Acid (EPA) Alleviates Oxidative Stress and Inflammatory Responses in Canine Ileal Epithelial Cells. | Fueled by the rapid growth of the global companion animal industry, the development of nutritional additives for improving canine intestinal health has emerged as a prominent research area in pet nutrition. Excessive reactive oxygen species accumulation triggers severe oxidative stress, inducing intestinal inflammation... | [
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MED:42651919 | 42651919 | MED | 42651919 | PMC13508923 | 10.3390/ani16162515 | Effects of Complementary Feed with Postbiotics Derived from <i>Bacillus subtilis</i> on Nutrient Digestibility, Faecal Characteristics, Gut Microbiota, Metabolic and Immune Responses, and Coat Quality in Healthy Senior Dogs. | The aim of this study was to evaluate the effects of a <i>Bacillus subtilis</i>-derived postbiotic on apparent total tract nutrient digestibility, faecal fermentation characteristics, gut microbiota, immune response, blood biochemistry, hematological parameters, serum trace minerals, and coat quality in healthy senior ... | [
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MED:42645464 | 42645464 | MED | 42645464 | PMC13510857 | 10.3390/dj14080490 | Retentive Force Assessment and Wear Exploration of CAD-CAM Fabricated PEEK, Zirconia, and PMMA Mini Ball Attachments for Tooth-Supported Overdenture: A Laboratory Study. | <b>Background/Objectives</b>: The longevity of tooth-supported overdentures depends on the retentive stability of attachment systems, yet limited evidence exists on the performance of non-metallic CAD-CAM fabricated mini ball attachments. This study aimed to evaluate the retentive force changes and surface wear of CAD-... | [
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MED:42629518 | 42629518 | MED | 42629518 | null | 10.1007/s11357-026-02482-7 | Human-analogue age-related dynamics of dog-human attachment. | Family dogs' human-analogue attachment to the owner has long been recognised; however, how this dog-owner attachment develops and changes with age remains an open question. We examined age-related variation and the effect of training experience on the attachment behaviour in family dogs (N = 222) using the Strange Sit... | [
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MED:42624279 | 42624279 | MED | 42624279 | null | 10.1016/j.tvjl.2026.106841 | Lesion distribution based on oral biopsy and histopathology in dogs: A retrospective study of 338 cases (2015-2025). | The histopathologic spectrum of canine oral lesions can vary significantly by geographic region and breed demographics. This retrospective study aimed to characterize the distribution of 338 biopsy-confirmed canine oral masses in the Republic of Korea, where small-breed dogs predominate. Lesions were categorized into t... | [
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MED:42594946 | 42594946 | MED | 42594946 | null | 10.2460/ajvr.26.06.0245 | Targeted quantitative polymerase chain reaction-based bacterial and fecal metabolite markers show early stability in healthy puppies after 8 weeks of age. | <h4>Objective</h4>To assess longitudinal stability of targeted quantitative PCR (qPCR)-based fecal microbial and metabolomic markers in healthy puppies from 8 weeks to 1 year of age.<h4>Methods</h4>This prospective longitudinal cohort study was conducted at the Clinic for Small Animal Internal Medicine, Vetsuisse Facul... | [
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MED:42572116 | 42572116 | MED | 42572116 | PMC13454156 | 10.1111/vop.70245 | Breed-Specific Relationship Between Rebound Tonometers (TonoVet and TonoVet Plus) in Labrador Retrievers. | <h4>Objective</h4>This study aimed to characterize the relationship between intraocular pressure (IOP) measurements obtained using two rebound tonometers (TonoVet and TonoVet Plus) in Labrador retrievers and to evaluate a regression-based approximation for supporting longitudinal interpretation following device replace... | [
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MED:42571817 | 42571817 | MED | 42571817 | null | 10.1016/j.tvjl.2026.106817 | Sleep-wake disturbance in canine cognitive dysfunction: Guardian-reported patterns and a practical screening tool. | Sleep-wake disturbance is a commonly reported feature of canine cognitive dysfunction (CCD), yet its specific patterns and clinical significance remain poorly characterised. This study aimed to describe guardian-reported sleep disturbances in dogs with CCD, examine their associations with cognitive severity and sensory... | [
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MED:42566137 | 42566137 | MED | 42566137 | PMC13451518 | 10.1007/s11259-026-11425-8 | Advances in biomarker discovery for canine cognitive dysfunction: a comprehensive structured narrative review and future perspectives. | Canine Cognitive Dysfunction (CCD) is a naturally occurring neurodegenerative syndrome in aging dogs that shares clinical and neuropathological parallels with Alzheimer's disease (AD). As the demand for objective diagnostic tools grows, identifying reliable biofluid biomarkers is essential for clinical staging and ther... | [
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MED:42564270 | 42564270 | MED | 42564270 | PMC13442920 | 10.1002/vro2.70047 | Minimally processed, human-grade diet alters canine epigenetic ageing: Results from a pilot study. | <h4>Background</h4>Diet plays a critical role in promoting wellness and longevity in both humans and canines. Epigenetic ageing clocks have emerged as accurate tools for assessing biological ageing and evaluating dietary and lifestyle interventions in humans and mice.<h4>Methods</h4>A dog-specific epigenetic ageing clo... | [
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MED:42561385 | 42561385 | MED | 42561385 | PMC13446794 | 10.2196/86944 | Acceptability and Usability of Telemedicine for Older Veterans in a Pilot Sample: Mixed Methods Study. | <h4>Background</h4>Telemedicine offers promising solutions for improving access to care among older adults with chronic conditions, but there is limited evidence on how older patients navigate and engage with video telehealth in their home environments.<h4>Objective</h4>This study aimed to assess older adults' acceptab... | [
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MED:42553616 | 42553616 | MED | 42553616 | PMC13435256 | 10.1155/crve/3637175 | Synchronous Multiple Primary Tumors in a Dog: A Case Report. | Multiple primary tumors (MPTs) are rare in dogs and challenging to diagnose when distinct lesions coexist. A 9-year-old mixed-breed female presented with mammary and cutaneous masses. Imaging revealed no pulmonary metastasis but metallic foreign bodies. Histopathology identified a low-grade intraductal carcinoma (HER2-... | [
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MED:42549302 | 42549302 | MED | 42549302 | PMC13430713 | 10.3389/fvets.2026.1854150 | Case Report: Modified pulse-dose melphalan therapy for canine colorectal extramedullary plasmacytoma with suspected hepatic dissemination following surgical excision. | A senior male neutered Maltese dog was diagnosed with a solitary rectal extramedullary plasmacytoma that was completely excised with clean margins. 5 months later, multifocal hepatic plasma cell tumors were identified without evidence of multiple myeloma. Systemic chemotherapy was initiated using a pulse-dose melphalan... | [
"Chen Y"
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MED:42549273 | 42549273 | MED | 42549273 | PMC13431295 | 10.7717/peerj.21560 | Dog ownership and healthy brain aging: a pilot study. | <h4>Background</h4>Dog ownership may benefit brain and cognitive health by supporting physical activity and social connectedness, among other mechanisms. Studies that include brain health outcomes (<i>e.g.</i>, neuroimaging outcomes) are lacking. As the population ages, studies investigating whether and how dogs suppor... | [
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MED:42546493 | 42546493 | MED | 42546493 | null | 10.1016/j.jcpa.2026.07.003 | Triple amyloidosis involving fibrinogen Aα-chain, apolipoprotein A-I and EGF-containing fibulin-like matrix protein 1 in an aged dog. | Amyloidosis is a group of disorders characterized by the deposition of misfolded proteins within the body, with disease subtypes classified based on the precursor protein. With the increasing longevity of captive animals, several forms of age-related amyloidosis have been reported in recent years, and attention to this... | [
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MED:42545213 | 42545213 | MED | 42545213 | null | 10.1177/08987564261470574 | Intraoral Radiographic Description of Dental Anatomy and Pathology in the Virginia Opossum (<i>Didelphis virginiana</i>). | While the gross dental anatomy of the Virginia opossum (<i>Didelphis virginiana</i>) has been described, the radiographic appearance of the dentition and the prevalence of dental and oral pathology have not been comprehensively evaluated. The objective of this study was to characterize the intraoral radiographic dental... | [
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"Wright AL",
"Peralta S",
"Vogelnest L",
"Fiani N"
] | Winokur CE, Wright AL, Peralta S, Vogelnest L, Fiani N. | Journal of veterinary dentistry | 2,026 | 2026-08-03T00:00:00 | [
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"Dental Radiography",
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MED:42541965 | 42541965 | MED | 42541965 | null | 10.1016/j.neurobiolaging.2026.07.009 | Amyloid-associated cognitive trajectories in aging dogs mirror early changes in humans. | Amyloid-β (Aβ) accumulation begins many years before the onset of clinical symptoms in Alzheimer's disease (AD). Studies in humans suggest that unimpaired individuals with elevated Aβ exhibit subtle changes in cognitive trajectories over time, particularly in memory. Identifying animal models that recapitulate these ea... | [
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MED:42526497 | 42526497 | MED | 42526497 | null | 10.2460/ajvr.26.05.0193 | Poor quality of life and recent veterinary consultation are associated with increased owner-perceived pain and/or suffering prior to euthanasia in dogs. | <h4>Objective</h4>To examine the influence of age, quality of life, illness, and recent veterinary consultation on an owner's perception of pain and/or suffering and consequently end-of-life decision-making for dogs.<h4>Methods</h4>This retrospective cohort study examined Dog Aging Project end-of-life survey data. Owne... | [
"Mann AM",
"O'Brien J",
"",
"Ruple A",
"Parker RL"
] | Mann AM, O'Brien J, Dog Aging Project Consortium, Ruple A, Parker RL. | American journal of veterinary research | 2,026 | 2026-07-29T00:00:00 | [
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] | eng | [] | [
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"Euthanasia",
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MED:42524431 | 42524431 | MED | 42524431 | PMC13411998 | 10.1590/1984-3143-ar2025-0125 | Exploring behavioral outcomes of gonadectomy in pets: a need for personalized approaches. | Gonadectomy, the surgical removal of reproductive organs-is commonly practiced in canine management and is often associated with responsible pet ownership. Although advised for preventing unwanted litter and specific health hazards, its effects on canine behavior remain contentious and little studied. This article anal... | [
"Guimarães FB",
"Barreto RO",
"Apparício M"
] | Guimarães FB, Barreto RO, Apparício M. | Animal reproduction | 2,026 | 2026-07-06T00:00:00 | [
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MED:42520843 | 42520843 | MED | 42520843 | null | 10.2460/ajvr.26.04.0153 | Service dogs in a matched survey were more physically active and had higher odds of being fed grain-free diets than companion dogs. | <h4>Objective</h4>There is a strong, bidirectional relation between the health outcomes of service dogs and their human handlers. Despite this relation, limited information is available on service dog health. This study assesses differences in health status, diet, and physical activity among service dogs and companion ... | [
"Otero DK",
"Wilson K",
"James TG"
] | Otero DK, Wilson K, James TG. | American journal of veterinary research | 2,026 | 2026-07-28T00:00:00 | [
"Journal Article"
] | eng | [] | [
"Primary Care",
"People With Disabilities",
"One Health",
"Service Dogs",
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MED:42520365 | 42520365 | MED | 42520365 | null | 10.1016/j.vaa.2026.101285 | Transient echocardiographic and cardiovascular changes temporally associated with trazodone administration in a geriatric dog. | A 14-year-old neutered male Toy Poodle was presented for elective bilateral phacoemulsification surgery. After initial physical examination at the hospital, oral trazodone (5 mg kg<sup>-1</sup>) was given approximately 2 hours before anaesthesia to facilitate preoperative handling. Approximately 1 hour after trazodone ... | [
"Sanchez Martinez CB",
"Rioja Garcia E"
] | Sanchez Martinez CB, Rioja Garcia E. | Veterinary anaesthesia and analgesia | 2,026 | 2026-07-08T00:00:00 | [
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{
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{
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MED:42511149 | 42511149 | MED | 42511149 | PMC13403947 | 10.3390/ani16142273 | Computer Simulation of Tooth Wear in Giant Pandas (<i>Ailuropoda melanoleuca</i>): Quantitative Predictions for Captive Health Management. | Tooth wear is a major health and welfare issue for captive giant pandas (<i>Ailuropoda melanoleuca</i>), but quantitative data on wear progression across different tooth types and chewing behaviors are lacking. In this study, a two-dimensional computer simulation (Processing, Java-based) was developed to model wear of ... | [
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"Lin H",
"Xiang J",
"Zhong Z",
"Peng G",
"Zhang K",
"Mo Q",
"Liu H",
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{
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MED:42503570 | 42503570 | MED | 42503570 | PMC13601471 | 10.1007/s11357-026-02429-y | LINE-1 CpG methylation in canine blood and cortical DNA tracks epigenetic changes with age. | Aging is accompanied by progressive epigenetic alterations, including changes in DNA methylation affecting both gene-associated regions and repetitive elements such as LINE-1 retrotransposons. Reduced epigenetic repression of transposable elements has been implicated in age-related genomic instability. Circulating cell... | [
"Jónás D",
"Tátrai K",
"Egyed B",
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] | Jónás D, Tátrai K, Egyed B, Kubinyi E. | GeroScience | 2,026 | 2026-07-27T00:00:00 | [
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},
{
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},
{
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MED:42499304 | 42499304 | MED | 42499304 | PMC13401139 | 10.1002/vms3.71088 | Green Tea Extract, Keratin Hydrolysate and Vitamin C Exert Anti-Ageing Effects Through the Hippo Signalling Pathway in Feline and Canine Mammary Gland Cells. | <h4>Background</h4>Ageing is a progressive decline in organ function and tissue integrity caused by genetic, environmental and physiological factors. With the increasing lifespan of companion animals, effective anti-ageing interventions for elderly felines and canines have attracted growing attention in veterinary medi... | [
"Gao Y",
"Sun X",
"Ma Y",
"Li J",
"Li Y",
"Lv L"
] | Gao Y, Sun X, Ma Y, Li J, Li Y, Lv L. | Veterinary medicine and science | 2,026 | 2026-07-01T00:00:00 | [
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MED:42492061 | 42492061 | MED | 42492061 | PMC13395076 | 10.1093/jvimsj/aalag125 | Effects of cow placenta extract on cognitive function in aged dogs: a randomized controlled trial. | <h4>Background</h4>Cow placenta extract (CPE) has demonstrated beneficial effects in antiaging; however, its effect on age-related cognitive decline remains unclear.<h4>Hypothesis/objectives</h4>To evaluate the potential therapeutic benefits of CPE in improving cognitive function in aged dogs.<h4>Animals</h4>The aged d... | [
"Lu J",
"Lu W",
"Qian XL"
] | Lu J, Lu W, Qian XL. | Journal of veterinary internal medicine | 2,026 | 2026-07-01T00:00:00 | [
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{
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MED:42490906 | 42490906 | MED | 42490906 | PMC13375494 | 10.3389/fvets.2026.1857970 | Case Report: Suspected hereditary spontaneous hydrocephalus in a Beagle pedigree. | <h4>Introduction</h4>Hydrocephalus is one of the most common malformations in dogs and poses considerable treatment challenges in veterinary clinical practice. Ventricular enlargement may represent an early manifestation of hydrocephalus and is commonly quantified by the ventricle-to-brain index (VBI). This report pres... | [
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"Han J",
"Liu Y",
"Xing Y",
"Liu YH",
"Zhang YP"
] | Fu JW, Liu JY, Jin DJ, Huang JJ, Yang S, Deng JK, Gao Y, Han J, Liu Y, Xing Y, Liu YH, Zhang YP. | Frontiers in veterinary science | 2,026 | 2026-07-03T00:00:00 | [
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MED:42485503 | 42485503 | MED | 42485503 | PMC13390968 | 10.1002/vms3.71105 | Targeting the Gut-Brain Axis: Pharmacological Modulation of the Microbiome for Neurological and Behavioural Disorders in Companion Animals. | <h4>Background</h4>The gut-brain axis (GBA) represents a paradigm shift in veterinary neuropharmacology, offering novel approaches for managing neurological and behavioural disorders in companion animals.<h4>Objectives</h4>This review synthesizes current evidence on the bidirectional communication between the gut micro... | [
"Khanamani Falahatipour S",
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MED:42482555 | 42482555 | MED | 42482555 | PMC13399023 | 10.1002/1878-0261.70293 | Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease. | Cachexia, a severe muscle-wasting syndrome, lacks objective biomarkers for early detection. This study aimed to identify circulating microRNA signatures for cachexia and cancer in senior dogs, a comparative oncology model for human disease. Serum microRNA expression was quantified in a cohort of 25 dogs, clinically cla... | [
"Park SS",
"An K",
"Kim G",
"Choi SN",
"Lee HK",
"Hur K",
"Jeong KS"
] | Park SS, An K, Kim G, Choi SN, Lee HK, Hur K, Jeong KS. | Molecular oncology | 2,026 | 2026-07-22T00:00:00 | [
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{
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{
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MED:42477997 | 42477997 | MED | 42477997 | PMC13384962 | 10.1093/gerona/glag163 | The relationship between parity and late-life frailty: companion dogs as a preclinical model for evaluating factors that aggravate or mitigate the frailty cost of reproduction. | Frailty refers to a state of heightened vulnerability to adverse health outcomes. Animal models of frailty provide an opportunity to probe lifetime events and exposures that drive frailty progression and to evaluate intervention strategies that could mitigate frailty development and its consequences in older adults. Th... | [
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"Maras AH",
"Fu R",
"Carrillo AE",
"Chiang EC",
"Suckow CL"
] | Waters DJ, Maras AH, Fu R, Carrillo AE, Chiang EC, Suckow CL. | The journals of gerontology. Series A, Biological sciences and medical sciences | 2,026 | 2026-07-01T00:00:00 | [
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{
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MED:42467133 | 42467133 | MED | 42467133 | PMC13379502 | 10.1007/s11259-026-11407-w | A comparative analysis of gut microbiome in dogs using short- and long-reads of 16S rRNA sequences reveals workflow-dependent biases. | Short-read Illumina sequencing of hypervariable regions of the 16S rRNA gene and long-read Oxford Nanopore Technologies (ONT) sequencing of the full-length 16S gene are increasingly used to profile microbial communities. However, differences in sequencing chemistry, read length, and taxonomic assignment methods raise c... | [
"Polacchini G",
"Stefanon B",
"Mongillo P",
"Licastro D"
] | Polacchini G, Stefanon B, Mongillo P, Licastro D. | Veterinary research communications | 2,026 | 2026-07-17T00:00:00 | [
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MED:42466752 | 42466752 | MED | 42466752 | null | 10.1177/15473287261467226 | Long-Term Survival, Illness Severity, and Time-to-Treatment Analysis in Dogs with Immune-Mediated Hemolytic Anemia Following Intravenous Allogeneic Mesenchymal Stem Cell Therapy: A Multicohort Follow-Up Study. | Steroid-refractory immune-mediated hemolytic anemia (IMHA) in dogs carries high early mortality, and the 15%-30% of cases that fail corticosteroid-based therapy represent a population with few effective options and a narrowing treatment window. In a prior retrospective study, intravenous allogeneic mesenchymal stem cel... | [
"Garner SD",
"Laughrun ED",
"Wharton M"
] | Garner SD, Laughrun ED, Wharton M. | Stem cells and development | 2,026 | 2026-07-17T00:00:00 | [
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MED:42466647 | 42466647 | MED | 42466647 | PMC13535439 | 10.1093/g3journal/jkag195 | Genotypic and phenotypic consequences of domestication in dogs. | Runs of homozygosity (ROH) are genomic regions that arise when identical haplotypes are inherited from a shared ancestor. In this study, we explored ROH across 556 whole-genome sequences from domesticated and non-domesticated dogs. Then, we leveraged ROH from 466 breed dogs, representing 13 breed groups and 13 phenotyp... | [
"Sweetalana",
"Nataneli S",
"Huang S",
"Mooney JA",
"Szpiech ZA"
] | Sweetalana, Nataneli S, Huang S, Mooney JA, Szpiech ZA. | G3 (Bethesda, Md.) | 2,026 | 2026-09-01T00:00:00 | [
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MED:42444957 | 42444957 | MED | 42444957 | PMC13358822 | 10.21037/jtd-2026-1-0216 | Canine radiography and echocardiography sensor fusion for deep learning-based detection and classification of myxomatous mitral valve disease. | <h4>Background</h4>Early recognition of myxomatous mitral valve disease (MMVD) is crucial for extending the lifespan and improving the quality of life in dogs. Timely diagnosis allows clinicians to initiate medical therapy before the onset of congestive heart failure. However, early-stage MMVD is challenging to identif... | [
"Thepsupornkul K",
"Surachetpong SD",
"Kunapinun A",
"Dailey MN"
] | Thepsupornkul K, Surachetpong SD, Kunapinun A, Dailey MN. | Journal of thoracic disease | 2,026 | 2026-06-26T00:00:00 | [
"research-article",
"Journal Article"
] | eng | [] | [
"Dogs",
"Radiography",
"Echocardiography",
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MED:42441848 | 42441848 | MED | 42441848 | null | 10.1073/pnas.2528874123 | Age-associated epigenetic drift trajectory and cross-national disparities in accelerated aging in domestic dogs. | Aging is accompanied by both increasing interindividual heterogeneity and systematic, age-associated alterations in DNA methylation (DNAm). Here, we investigated these complementary dimensions of epigenetic aging in dogs using global and locus-specific measures of epigenetic drift alongside clock-based estimates of bio... | [
"Jang S",
"Kim SJ",
"Kang D",
"Hong CY",
"Bok EY",
"Lee SL",
"Choe YH",
"Kim J"
] | Jang S, Kim SJ, Kang D, Hong CY, Bok EY, Lee SL, Choe YH, Kim J. | Proceedings of the National Academy of Sciences of the United States of America | 2,026 | 2026-07-13T00:00:00 | [
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},
{
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{
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MED:42427973 | 42427973 | MED | 42427973 | PMC13345842 | 10.3389/fvets.2026.1814017 | Thoracic limb stride length is associated with cognitive impairment in aging dogs. | <h4>Introduction</h4>Changes in stride length have been linked to cognitive impairment in humans with dementia. In aging dogs, cognitive decline is accompanied by slower gait speed. However, the relationship between stride length and cognitive decline has not been investigated. This study examined whether height-adjust... | [
"Rafatpanah Baigi S",
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"Yang CC",
"Mondino A",
"Fefer G",
"Panek WK",
"Simon KE",
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"Gruen ME",
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] | Rafatpanah Baigi S, Stywall A, Yang CC, Mondino A, Fefer G, Panek WK, Simon KE, Case BC, Gruen ME, Olby NJ. | Frontiers in veterinary science | 2,026 | 2026-06-25T00:00:00 | [
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MED:42418481 | 42418481 | MED | 42418481 | null | 10.1073/pnas.2537622123 | Inhibition of elastin degradation alleviates joint degeneration in aging mice, dogs, and human models. | Extracellular matrix degradation is a fundamental pathological feature of osteoarthritis, while the roles of degraded matrix remain largely unknown. We previously showed that serum elastin fragments were a systemic aging driver. Here, we found that elastin fragments were upregulated in synovial fluid in dual-center ost... | [
"Yi J",
"Xiao X",
"Zhang H",
"Xu X",
"Chen K",
"Cai X",
"Zhu Y",
"Mo X",
"Xiong S",
"Chen Z",
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"Wu J",
"Xu J",
"Chen X",
"Wu Y",
"Yin Z",
"Cai Y",
"Zhang X",
"Zhou J",
"Liu H",
"Ouyang H"
] | Yi J, Xiao X, Zhang H, Xu X, Chen K, Cai X, Zhu Y, Mo X, Xiong S, Chen Z, Sui H, Wu J, Xu J, Chen X, Wu Y, Yin Z, Cai Y, Zhang X, Zhou J, Liu H, Ouyang H. | Proceedings of the National Academy of Sciences of the United States of America | 2,026 | 2026-07-08T00:00:00 | [
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MED:42416796 | 42416796 | MED | 42416796 | PMC13340192 | 10.1293/tox.2025-0191 | International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and proliferative lesions of fish - Chapter 1. Introduction. | The INHAND Project is a joint initiative of the societies of toxicologic pathology from Europe, the United Kingdom, Japan, and North America to standardize diagnostic nomenclature and criteria used in toxicologic studies. The INHAND initiative includes recommended nomenclature for evaluating histologic specimens from n... | [
"Baumgartner W",
"Bach U",
"Baily J",
"Ruehl-Fehlert C",
"Fossey S",
"Furukawa S",
"Kato Y",
"Laast V",
"Meseck E",
"Schmidt-Posthaus H",
"Segner H",
"Shanmukhappa SK",
"Spitsbergen J",
"Wolf J"
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MED:42405723 | 42405723 | MED | 42405723 | null | 10.1638/2025-0085 | ADRENAL GLAND LESIONS IN AFRICAN PAINTED DOGS (<i>LYCAON PICTUS</i>) OF THE ASSOCIATION OF ZOOS AND AQUARIUMS SPECIES SURVIVAL PLAN<sup>®</sup> POPULATION. | African painted dogs (<i>Lycaon pictus</i>; APD) are an endangered canid species with sophisticated behaviors and social structure. In the United States, there are approximately 160 individuals housed at institutions accredited by the Association of Zoos and Aquariums, where health and disease are monitored, and breedi... | [
"Kane LP",
"Garner MM",
"Vaughan CA",
"Terrell H",
"Kinsel MJ",
"Delaney MA"
] | Kane LP, Garner MM, Vaughan CA, Terrell H, Kinsel MJ, Delaney MA. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians | 2,026 | 2026-06-01T00:00:00 | [
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MED:42405640 | 42405640 | MED | 42405640 | null | 10.1177/10556656261466058 | A Comparison of a Novel Passive Nasoalveolar Molding Technique Versus Traditional Active Molding for Alveolar Cleft Reduction. | ObjectiveWe developed a hybrid technique, termed passive nasoalveolar molding (PNAM). The primary objective of this study is to compare the efficacy of PNAM to the established Grayson technique for nasoalveolar molding (NAM) in reducing the alveolar cleft in patients with clefts involving the lip and primary palate.Des... | [
"Qureshi UA",
"Hallman T",
"Rai P",
"Shah ND",
"Jacobson R",
"Ford J",
"Gosain AK"
] | Qureshi UA, Hallman T, Rai P, Shah ND, Jacobson R, Ford J, Gosain AK. | The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association | 2,026 | 2026-07-06T00:00:00 | [
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MED:42395196 | 42395196 | MED | 42395196 | PMC13326846 | 10.7759/cureus.110121 | Outcomes in the Older Appalachian Trauma Population After Falls Caused by Dogs: Who Let the Dogs Out? | Introduction Falls continue to be among the leading causes of nonfatal injuries in the United States. Falls are common among the older population, and the Appalachian region is considered one with an aging population. Pet ownership is common and has even increased since 2020. Few studies exist on the topic of falls cau... | [
"Burns AG",
"Mannino E",
"Leonard M",
"Collins H",
"Burns B"
] | Burns AG, Mannino E, Leonard M, Collins H, Burns B. | Cureus | 2,026 | 2026-06-02T00:00:00 | [
"research-article",
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"Rural areas",
"Fall Prevention",
"Accidental Falls",
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MED:42389443 | 42389443 | MED | 42389443 | PMC13320194 | 10.3892/etm.2026.13218 | Postbiotic metabolites from <i>Bifidobacterium adolescentis</i> alleviates doxorubicin-induced aging in canine vascular endothelial cells. | Cardiovascular aging represents the initial stage of systemic bodily aging. Endothelial cell (EC) senescence serves a key role in vascular aging. However, therapeutic strategies targeting ECs senescence remain insufficiently explored. The present study aimed to assess the anti-aging effects of metabolites derived from ... | [
"Jin H",
"Bai H",
"Liu T",
"Wang H",
"Li Y",
"Wang Z"
] | Jin H, Bai H, Liu T, Wang H, Li Y, Wang Z. | Experimental and therapeutic medicine | 2,026 | 2026-06-23T00:00:00 | [
"research-article",
"Journal Article"
] | eng | [] | [
"Metabolomics",
"Transcriptomics",
"Bifidobacterium Adolescentis",
"Postbiotic Metabolites",
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MED:42388534 | 42388534 | MED | 42388534 | PMC13319405 | 10.1002/trc2.70281 | Meeting report for the Second International Conference on Unconventional Animal Models of Alzheimer's Disease and Aging (UAMAA 2026). | The Second International Conference on Unconventional Animal Models of Alzheimer's Disease and Aging (UAMAA 2026) was held February 9 through 11, 2026, in Irvine, California. Building upon the inaugural meeting in Santiago, Chile (2023), this conference expanded an international effort to develop, characterize, and rig... | [
"Alshami J",
"Wu G",
"Garduño BM",
"Silva AC",
"Rizzo SJS",
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"Xu X"
] | Alshami J, Wu G, Garduño BM, Silva AC, Rizzo SJS, Cogram P, Xu X. | Alzheimer's & dementia (New York, N. Y.) | 2,026 | 2026-06-30T00:00:00 | [
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"Octodon Degus",
"Non‐human Primates",
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"Naked Mole‐rat"
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MED:42385685 | 42385685 | MED | 42385685 | null | 10.1055/a-2854-5523 | [Radiographic appearance of anatomical variants around the canine stifle joint - a pictorial essay]. | <h4>Abstract</h4>This pictorial review describes and illustrates several anatomical variations in the radiographic appearance of the canine stifle. These variations may involve intra- and extra-articular structures, such as femur, tibia, fibula, and sesamoid bones. They vary in prevalence, are generally asymptomatic, a... | [
"Ludewig E",
"Jopp I"
] | Ludewig E, Jopp I. | Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere | 2,026 | 2026-06-01T00:00:00 | [
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{
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MED:42379387 | 42379387 | MED | 42379387 | null | 10.1016/j.tvjl.2026.106766 | Brain mineral concentrations in canine cognitive dysfunction. | Canine cognitive dysfunction (CCD) is a prevalent age-related neurodegenerative condition in dogs that shares several features with Alzheimer's disease (AD). Although mineral dyshomeostasis has been implicated in the pathogenesis of AD, its role in CCD remains largely unexplored. This retrospective study aimed to inves... | [
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"Insua D",
"Suárez ML",
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] | Larrán B, López-Alonso M, Miranda M, González-Martínez Á, Rosado B, García-Belenguer S, Herrero-Latorre C, Insua D, Suárez ML, Santamarina G, Orjales I. | Veterinary journal (London, England : 1997) | 2,026 | 2026-06-30T00:00:00 | [
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MED:42376422 | 42376422 | MED | 42376422 | PMC13314081 | 10.5455/ovj.2026.v16.i2.55 | Chronic kidney disease in a dog with hematologic and cardiovascular alterations: A case report. | <h4>Background</h4>Chronic kidney disease (CKD) is a common and progressive disorder in dogs characterized by irreversible loss of renal function over time. It is frequently observed in geriatric dogs and may present with nonspecific clinical signs that require careful diagnostic evaluation for confirmation.<h4>Case de... | [
"Wijaya A",
"Yunus M"
] | Wijaya A, Yunus M. | Open veterinary journal | 2,026 | 2026-02-28T00:00:00 | [
"research-article",
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"Case Reports"
] | eng | [
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MED:42365602 | 42365602 | MED | 42365602 | PMC13321205 | 10.1016/j.tjfa.2026.100181 | An OLD DOG teaching us new tricks in ageing biology. | null | [
"Carvalho OMS",
"Abukwaik A",
"Sultan O",
"Koizia LJ",
"Harris BHL"
] | Carvalho OMS, Abukwaik A, Sultan O, Koizia LJ, Harris BHL. | The Journal of frailty & aging | 2,026 | 2026-06-28T00:00:00 | [
"Letter"
] | eng | [] | [
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"One Health",
"Old Dog"
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MED:42348149 | 42348149 | MED | 42348149 | null | 10.1007/s44463-026-00090-9 | Impact of xylose-mediated Maillard reaction on antioxidant capacity and digestibility of alcalase-hydrolyzed porcine liver during simulated canine digestion. | <h4>Purpose</h4>The growing population of aging dogs has stimulated a demand for functional dietary ingredients that can support long-term health and metabolic stability. Antioxidant properties and digestive stability of porcine liver hydrolysates produced by enzymatic hydrolysis and subsequent Maillard reaction were i... | [
"Hwang J",
"Son WY",
"Youn JH",
"Na YJ",
"Jeong EJ",
"Shin EC",
"Kim KS",
"Park KI",
"Chun JL",
"Sringarm K",
"Arjin C",
"Srinual O",
"Kim HW"
] | Hwang J, Son WY, Youn JH, Na YJ, Jeong EJ, Shin EC, Kim KS, Park KI, Chun JL, Sringarm K, Arjin C, Srinual O, Kim HW. | Food science of animal resources | 2,026 | 2026-06-25T00:00:00 | [
"Journal Article"
] | eng | [] | [
"Maillard reaction",
"Enzymatic hydrolysis",
"Pet Food",
"Canine In Vitro Digestion",
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{
"grant_id": "Project No. RS-2023-00231446",
"agency": "Rural Development Administration",
"acronym": null
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] | false | false | false | false | cc by-nc-nd | 0 | [
{
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MED:42347529 | 42347529 | MED | 42347529 | null | 10.3390/tropicalmed11060144 | Zoonotic Spillover of a Canine-like Rotavirus A G3P[3] Strain in a Brazilian Child. | Rotavirus A (RVA) G3P[3] genotype is widely reported in dogs and less frequently in cats, with only sporadic human cases worldwide. All reported human infections have occurred in children, suggesting increased susceptibility likely linked to close contact with pets and age-related hygiene practices. The identification ... | [
"Silva VCM",
"Azevedo LS",
"Guiducci R",
"Luchs A"
] | Silva VCM, Azevedo LS, Guiducci R, Luchs A. | Tropical medicine and infectious disease | 2,026 | 2026-05-26T00:00:00 | [
"Journal Article"
] | eng | [] | [
"Genetic diversity",
"Rotavirus",
"Molecular epidemiology",
"Gastroenteritis",
"Interspecies Transmission"
] | [
{
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{
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"agency": "Special Health Fund for Mass Immunization and Disease Control (FESIMA)",
"acronym": null
},
{
"grant_id"... | false | false | false | false | null | 0 | [
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MED:42344323 | 42344323 | MED | 42344323 | PMC13290352 | 10.14202/vetworld.2026.1838-1849 | <i>Neospora caninum</i> infection and reproductive disorders in Creole goats from southern Peru: A Bayesian mediation analysis across agroecological zones. | <h4>Background and aim</h4>Neosporosis, caused by <i>Neospora caninum</i>, is an important infectious cause of reproductive failure in ruminants, yet its epidemiological role in goats from hyper-arid coastal ecosystems remains poorly understood. In southern Peru, Creole goat production is predominantly extensive, with ... | [
"Soca J",
"Trillo-Salvador M",
"Valdivia-Zevallos J",
"Canchino-Gutierrez J",
"Sessarego EA",
"Mendoza-Alacute E",
"Temoche-Socola V",
"Cruz-Luis J",
"Cruz DJ"
] | Soca J, Trillo-Salvador M, Valdivia-Zevallos J, Canchino-Gutierrez J, Sessarego EA, Mendoza-Alacute E, Temoche-Socola V, Cruz-Luis J, Cruz DJ. | Veterinary world | 2,026 | 2026-05-10T00:00:00 | [
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"risk factors",
"Neospora Caninum",
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"Agroecological Zones",
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MED:42337050 | 42337050 | MED | 42337050 | PMC13503687 | 10.1038/s41598-026-59321-0 | Reliability, repeatability, and age associations of the dogSIT (dog Smell Interaction Test) battery in untrained companion dogs (Canis lupus familiaris). | Current olfactory tests for untrained dogs have limitations due to use of a single odorant, requirement for ambulation, and potential for vision interference. We hypothesized that our new dogSIT odorant test battery measures would be reliable, repeatable, and age-associated in untrained companion dogs. Gently restraine... | [
"Corona AC",
"Harrison H",
"Hopper RG",
"Smith AL",
"Rogers CM",
"Cook CL",
"Salzman MM",
"Peterson KD",
"Hall NJ",
"Mowat FM"
] | Corona AC, Harrison H, Hopper RG, Smith AL, Rogers CM, Cook CL, Salzman MM, Peterson KD, Hall NJ, Mowat FM. | Scientific reports | 2,026 | 2026-06-23T00:00:00 | [
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... | [
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"agency": "NIA NIH HHS",
"acronym": "AG"
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{
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"agency": "National Institute on Aging",
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{
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"agency": "NEI NIH HHS",
"acronym": "EY"
},
{
"grant_id": "D23CA-510",
... | true | true | true | true | cc by-nc-nd | 0 | [
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