Mixed-source data notice No single blanket licence is asserted for this package. 1. OA2025-derived annotations and supplementary material retain the Creative Commons Attribution 4.0 International licence: https://creativecommons.org/licenses/by/4.0/ Source DOI: https://doi.org/10.1038/s41586-025-08771-z 2. Reference-sequence windows were generated from the UCSC hg38 FASTA and retain the applicable source and assembly terms and attribution. 3. Cembra-specific selection, matching, fold, provenance, and documentation retain the Cembra repository's proprietary / all-rights-reserved boundary. This notice does not grant rights beyond those provided by each upstream source. The package is provided for research reproduction without warranty and is not validated for clinical use.