Sync camilloh3k27me3
Browse files- README.md +38 -0
- camilloh3k27me3.pt +3 -0
- config.json +34 -0
README.md
ADDED
|
@@ -0,0 +1,38 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
+
---
|
| 2 |
+
license: bsd-3-clause
|
| 3 |
+
library_name: pyaging
|
| 4 |
+
tags:
|
| 5 |
+
- pyaging
|
| 6 |
+
- aging-clock
|
| 7 |
+
- biology
|
| 8 |
+
- histone-modification
|
| 9 |
+
---
|
| 10 |
+
|
| 11 |
+
# camilloh3k27me3
|
| 12 |
+
|
| 13 |
+
Pan-tissue chronological-age predictor trained on gene-level H3K27me3 ChIP-seq enrichment; ElasticNet feature selection is followed by truncated-SVD PCA and automatic relevance determination regression.
|
| 14 |
+
|
| 15 |
+
| | |
|
| 16 |
+
|---|---|
|
| 17 |
+
| **Predicts** | chronological age |
|
| 18 |
+
| **Species** | Homo sapiens |
|
| 19 |
+
| **Tissue** | multi-tissue |
|
| 20 |
+
| **Data type** | histone modification |
|
| 21 |
+
| **Model type** | PCA + elastic net + ARD regression |
|
| 22 |
+
| **Year** | 2025 |
|
| 23 |
+
|
| 24 |
+
## Use with pyaging
|
| 25 |
+
|
| 26 |
+
```python
|
| 27 |
+
import pyaging as pya
|
| 28 |
+
|
| 29 |
+
pya.pred.predict_age(adata, ["camilloh3k27me3"])
|
| 30 |
+
```
|
| 31 |
+
|
| 32 |
+
Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io).
|
| 33 |
+
|
| 34 |
+
## Citation
|
| 35 |
+
|
| 36 |
+
de Lima Camillo, L. P., Asif, M. H., Horvath, S., Larschan, E., & Singh, R. Histone mark age of human tissues and cell types. Science Advances 11, eadk9373 (2025).
|
| 37 |
+
|
| 38 |
+
https://doi.org/10.1126/sciadv.adk9373
|
camilloh3k27me3.pt
ADDED
|
@@ -0,0 +1,3 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
+
version https://git-lfs.github.com/spec/v1
|
| 2 |
+
oid sha256:9af151ba98cf798f2e4a8e4722f88628f0b1e6f318def93f5d145e734e1d74bf
|
| 3 |
+
size 2169821
|
config.json
ADDED
|
@@ -0,0 +1,34 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
+
{
|
| 2 |
+
"approved_by_author": "\u2705",
|
| 3 |
+
"citation": "de Lima Camillo, L. P., Asif, M. H., Horvath, S., Larschan, E., & Singh, R. Histone mark age of human tissues and cell types. Science Advances 11, eadk9373 (2025).",
|
| 4 |
+
"citations": 4,
|
| 5 |
+
"citations_date": "2026-07-05",
|
| 6 |
+
"clock_name": "camilloh3k27me3",
|
| 7 |
+
"data_type": "histone modification",
|
| 8 |
+
"doi": "https://doi.org/10.1126/sciadv.adk9373",
|
| 9 |
+
"journal": "Science Advances",
|
| 10 |
+
"last_author": "Ritambhara Singh",
|
| 11 |
+
"model_type": "PCA + elastic net + ARD regression",
|
| 12 |
+
"n_features": 922,
|
| 13 |
+
"notes": "Pan-tissue chronological-age predictor trained on gene-level H3K27me3 ChIP-seq enrichment; ElasticNet feature selection is followed by truncated-SVD PCA and automatic relevance determination regression.",
|
| 14 |
+
"platform": [
|
| 15 |
+
"ChIP-seq"
|
| 16 |
+
],
|
| 17 |
+
"population": "all ages",
|
| 18 |
+
"predicts": [
|
| 19 |
+
"chronological age"
|
| 20 |
+
],
|
| 21 |
+
"research_only": null,
|
| 22 |
+
"species": "Homo sapiens",
|
| 23 |
+
"tissue": [
|
| 24 |
+
"multi-tissue"
|
| 25 |
+
],
|
| 26 |
+
"training_target": [
|
| 27 |
+
"chronological age"
|
| 28 |
+
],
|
| 29 |
+
"unit": [
|
| 30 |
+
"years"
|
| 31 |
+
],
|
| 32 |
+
"version": "v0.3.0",
|
| 33 |
+
"year": 2025
|
| 34 |
+
}
|