{
 "approved_by_author": "\u231b",
 "citation": "Salas, L.A., Koestler, D.C., Butler, R.A. et al. An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray. Genome Biology 19, 64 (2018).",
 "citations": 487,
 "citations_date": "2026-10-02",
 "clock_name": "deconvolutebloodepiccd4tcell",
 "data_type": "DNA methylation",
 "doi": "https://doi.org/10.1186/s13059-018-1448-7",
 "journal": "Genome Biology",
 "last_author": "Brock C. Christensen",
 "model_type": "reference-based constrained deconvolution",
 "n_features": 600,
 "notes": "Reference-based constrained deconvolution returning the CD4+ T cell proportion from EPIC-array blood methylation. Pyaging uses the paper's automatic 600-CpG top-hypermethylated/top-hypomethylated reference, not the paper's preferred 450-CpG EPIC IDOL library.",
 "platform": [
  "Illumina EPIC"
 ],
 "population": "adults",
 "predicts": [
  "CD4+ T cell proportion"
 ],
 "preprocess": "fill_with_reference_means",
 "reference_values": true,
 "research_only": null,
 "species": "Homo sapiens",
 "tissue": [
  "purified blood leukocytes"
 ],
 "training_target": [
  "cell-type-specific methylation contrast"
 ],
 "unit": [
  "proportion"
 ],
 "version": "0.5.7",
 "year": 2018
}