---
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
---

# dnamfili

Epigenetic frailty risk score (eFRS), a weighted 20-CpG whole-blood DNA-methylation score selected by LASSO from replicated frailty-associated loci.

Model weights retain the original authors' terms; the pyaging software license does not relicense them.

| | |
|---|---|
| **Predicts** | frailty risk |
| **Species** | Homo sapiens |
| **Tissue** | whole blood |
| **Data type** | DNA methylation |
| **Model type** | LASSO regression |
| **Year** | 2022 |

## Use with pyaging

```python
import pyaging as pya

pya.pred.predict_age(adata, ["dnamfili"])
```

Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io).

## Citation

Li, X. et al. Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults. Nature Communications 13, 5269 (2022).

https://doi.org/10.1038/s41467-022-32893-x