gliasin

Glia-Sin is a glia semi-intrinsic chronological-age clock: elastic-net regression was restricted to glia age-DMCTs but fitted to methylation values not adjusted for brain cell fractions. Coefficients were fitted in the 450K Jaffe cortex cohort; the regularization penalty was selected on the EPIC Pihlstrom cohort.

Model weights retain the original authors' terms; the pyaging software license does not relicense them.

Predicts	chronological age
Species	Homo sapiens
Tissue	brain cortex
Data type	DNA methylation
Model type	elastic net regression
Year	2024

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["gliasin"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Tong, Huige, et al. "Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution." Aging 16 (2024): 14204–14237.

https://doi.org/10.18632/aging.206184