xchrom

X-chromosome first-principal-component score used with the Y score to infer X dosage and classify 46,XX, 46,XY, 45,X, and 47,XXY samples. Feature screening and PCA used 450K whole-blood data from 18-year-olds; EPIC data were used for validation.

Model weights retain the original authors' terms; the pyaging software license does not relicense them.

Predicts	X-chromosome dosage
Species	Homo sapiens
Tissue	whole blood
Data type	DNA methylation
Model type	principal component analysis
Year	2021

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["xchrom"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Wang, Y. et al. DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy. BMC Genomics 22, 484 (2021).

https://doi.org/10.1186/s12864-021-07675-2