scvi-tools
/

tabula-sapiens-skin-scvi

@@ -6,8 +6,8 @@ tags:
 - genomics
 - single-cell
 - model_cls_name:SCVI
-- scvi_version:1.2.0
-- anndata_version:0.11.1
 - modality:rna
 - tissue:various
 - annotated:True
@@ -20,7 +20,7 @@ The learned low-dimensional latent representation of the data can be used for vi
 clustering.
 scVI takes as input a scRNA-seq gene expression matrix with cells and genes.
-We provide an extensive [user guide](https://docs.scvi-tools.org/en/1.2.0/user_guide/models/scvi.html).
 - See our original manuscript for further details of the model:
 [scVI manuscript](https://www.nature.com/articles/s41592-018-0229-2).
@@ -28,7 +28,7 @@ We provide an extensive [user guide](https://docs.scvi-tools.org/en/1.2.0/user_g
 to leverage pre-trained models.
 This model can be used for fine tuning on new data using our Arches framework:
-[Arches tutorial](https://docs.scvi-tools.org/en/1.0.0/tutorials/notebooks/scarches_scvi_tools.html).
 # Model Description
@@ -49,24 +49,14 @@ space might still be useful for analysis.
 **Cell-wise Coefficient of Variation**:
-| Metric                  | Training Value | Validation Value |
-|-------------------------|----------------|------------------|
-| Mean Absolute Error | 2.29  | 2.37           |
-| Pearson Correlation | 0.63  | 0.61  |
-| Spearman Correlation | 0.61 | 0.59  |
-| R² (R-Squared) | 0.11  | 0.02      |
 The gene-wise coefficient of variation summarizes how well variation between different genes is
 preserved by the generated model expression. This value is usually quite high.
 **Gene-wise Coefficient of Variation**:
-| Metric                  | Training Value |
-|-------------------------|----------------|
-| Mean Absolute Error | 14.99   |
-| Pearson Correlation | 0.53  |
-| Spearman Correlation | 0.58 |
-| R² (R-Squared) | -2.17  |
 </details>
@@ -81,29 +71,7 @@ cell-type.
 **Differential expression**:
-| Index | gene_f1 | lfc_mae | lfc_pearson | lfc_spearman | roc_auc | pr_auc | n_cells |
-| --- | --- | --- | --- | --- | --- | --- | --- |
-| stromal cell | 0.89 | 1.25 | 0.70 | 0.96 | 0.45 | 0.90 | 2943.00 |
-| endothelial cell | 0.83 | 1.60 | 0.68 | 0.91 | 0.37 | 0.85 | 1309.00 |
-| CD8-positive, alpha-beta memory T cell | 0.88 | 3.56 | 0.60 | 0.77 | 0.23 | 0.76 | 857.00 |
-| macrophage | 0.84 | 2.57 | 0.59 | 0.83 | 0.29 | 0.84 | 846.00 |
-| mast cell | 0.88 | 3.38 | 0.60 | 0.77 | 0.21 | 0.76 | 645.00 |
-| mature NK T cell | 0.86 | 3.82 | 0.59 | 0.74 | 0.24 | 0.74 | 605.00 |
-| T cell | 0.87 | 4.38 | 0.57 | 0.70 | 0.22 | 0.73 | 519.00 |
-| muscle cell | 0.90 | 3.41 | 0.61 | 0.78 | 0.36 | 0.79 | 437.00 |
-| CD4-positive, alpha-beta memory T cell | 0.86 | 4.72 | 0.57 | 0.66 | 0.24 | 0.72 | 339.00 |
-| CD1c-positive myeloid dendritic cell | 0.76 | 4.81 | 0.58 | 0.70 | 0.30 | 0.82 | 165.00 |
-| CD8-positive, alpha-beta cytotoxic T cell | 0.82 | 5.51 | 0.54 | 0.56 | 0.29 | 0.71 | 129.00 |
-| regulatory T cell | 0.83 | 5.05 | 0.60 | 0.63 | 0.29 | 0.77 | 126.00 |
-| epithelial cell | 0.71 | 4.65 | 0.59 | 0.71 | 0.36 | 0.71 | 106.00 |
-| naive thymus-derived CD8-positive, alpha-beta T cell | 0.80 | 5.71 | 0.55 | 0.54 | 0.29 | 0.75 | 88.00 |
-| naive thymus-derived CD4-positive, alpha-beta T cell | 0.71 | 5.43 | 0.55 | 0.55 | 0.30 | 0.72 | 71.00 |
-| melanocyte | 0.69 | 6.64 | 0.49 | 0.53 | 0.39 | 0.73 | 64.00 |
-| CD4-positive helper T cell | 0.77 | 5.76 | 0.52 | 0.52 | 0.32 | 0.74 | 59.00 |
-| Langerhans cell | 0.73 | 6.23 | 0.52 | 0.54 | 0.38 | 0.76 | 36.00 |
-| plasma cell | 0.51 | 7.20 | 0.43 | 0.40 | 0.36 | 0.75 | 24.00 |
-| CD141-positive myeloid dendritic cell | 0.67 | 6.38 | 0.54 | 0.54 | 0.27 | 0.75 | 17.00 |
-| smooth muscle cell | 0.55 | 6.17 | 0.50 | 0.48 | 0.38 | 0.69 | 13.00 |
 </details>
@@ -123,6 +91,7 @@ These provide the settings to setup the original model:
     "dropout_rate": 0.05,
     "dispersion": "gene",
     "gene_likelihood": "nb",
     "latent_distribution": "normal",
     "use_batch_norm": "none",
     "use_layer_norm": "both",
@@ -138,9 +107,9 @@ These provide the settings to setup the original model:
 Arguments passed to setup_anndata of the original model:
 ```json
 {
-    "layer": null,
     "batch_key": "donor_assay",
-    "labels_key": "cell_ontology_class",
     "size_factor_key": null,
     "categorical_covariate_keys": null,
     "continuous_covariate_keys": null
@@ -153,15 +122,15 @@ Arguments passed to setup_anndata of the original model:
 <summary><strong>Data Registry</strong></summary>
 Registry elements for AnnData manager:
-|   Registry Key    |         scvi-tools Location          |
-|-------------------|--------------------------------------|
-|         X         |               adata.X                |
-|       batch       |       adata.obs['_scvi_batch']       |
-|      labels       |      adata.obs['_scvi_labels']       |
-|    latent_qzm     |    adata.obsm['scvi_latent_qzm']     |
-|    latent_qzv     |    adata.obsm['scvi_latent_qzv']     |
-|    minify_type    | adata.uns['_scvi_adata_minify_type'] |
-| observed_lib_size |    adata.obs['observed_lib_size']    |
 - **Data is Minified**: False
@@ -170,16 +139,16 @@ Registry elements for AnnData manager:
 <details>
 <summary><strong>Summary Statistics</strong></summary>
-|     Summary Stat Key     | Value |
 |--------------------------|-------|
-|         n_batch          |   3   |
-|         n_cells          | 9398  |
-| n_extra_categorical_covs |   0   |
-| n_extra_continuous_covs  |   0   |
-|         n_labels         |  21   |
-|       n_latent_qzm       |  20   |
-|       n_latent_qzv       |  20   |
-|          n_vars          | 3000  |
 </details>

 - genomics
 - single-cell
 - model_cls_name:SCVI
+- scvi_version:1.4.2
+- anndata_version:0.12.7
 - modality:rna
 - tissue:various
 - annotated:True
 clustering.
 scVI takes as input a scRNA-seq gene expression matrix with cells and genes.
+We provide an extensive [user guide](https://docs.scvi-tools.org/en/stable/user_guide/models/scvi.html).
 - See our original manuscript for further details of the model:
 [scVI manuscript](https://www.nature.com/articles/s41592-018-0229-2).
 to leverage pre-trained models.
 This model can be used for fine tuning on new data using our Arches framework:
+[Arches tutorial](https://docs.scvi-tools.org/en/stable/tutorials/notebooks/scrna/scarches_scvi_tools.html).
 # Model Description
 **Cell-wise Coefficient of Variation**:
+Not provided by uploader
 The gene-wise coefficient of variation summarizes how well variation between different genes is
 preserved by the generated model expression. This value is usually quite high.
 **Gene-wise Coefficient of Variation**:
+Not provided by uploader
 </details>
 **Differential expression**:
+Not provided by uploader
 </details>
     "dropout_rate": 0.05,
     "dispersion": "gene",
     "gene_likelihood": "nb",
+    "use_observed_lib_size": true,
     "latent_distribution": "normal",
     "use_batch_norm": "none",
     "use_layer_norm": "both",
 Arguments passed to setup_anndata of the original model:
 ```json
 {
+    "layer": "counts",
     "batch_key": "donor_assay",
+    "labels_key": "cell_type",
     "size_factor_key": null,
     "categorical_covariate_keys": null,
     "continuous_covariate_keys": null
 <summary><strong>Data Registry</strong></summary>
 Registry elements for AnnData manager:
+| Registry Key             | scvi-tools Location                  |
+|--------------------------|--------------------------------------|
+| X                         | adata.layers['counts']               |
+| batch                     | adata.obs['_scvi_batch']             |
+| labels                    | adata.obs['_scvi_labels']            |
+| latent_qzm                | adata.obsm['scvi_latent_qzm']        |
+| latent_qzv                | adata.obsm['scvi_latent_qzv']        |
+| minify_type               | adata.uns['_scvi_adata_minify_type'] |
+| observed_lib_size         | adata.obs['observed_lib_size']       |
 - **Data is Minified**: False
 <details>
 <summary><strong>Summary Statistics</strong></summary>
+| Summary Stat Key          | Value |
 |--------------------------|-------|
+| n_batch                   | 7 |
+| n_cells                   | 17786 |
+| n_extra_categorical_covs  | 0 |
+| n_extra_continuous_covs   | 0 |
+| n_labels                  | 25 |
+| n_latent_qzm              | 20 |
+| n_latent_qzv              | 20 |
+| n_vars                    | 3000 |
 </details>