data/pathway_network.json

{
  "name": "Mitotic Spindle Assembly Checkpoint (SAC) & Centrosome Network",
  "description": "Functional protein-protein interaction architecture governing chromosome segregation and spindle-kinetochore attachment.",
  "complexes": [
    {
      "id": "MCC",
      "name": "Mitotic Checkpoint Complex (MCC)",
      "components": [
        "BUBR1 (BUB1B)",
        "BUB3",
        "MAD2L1",
        "CDC20"
      ],
      "role": "Inhibits Anaphase Promoting Complex/Cyclosome (APC/C) until all kinetochores are bioriented."
    },
    {
      "id": "Centrosome",
      "name": "Centriole & Centrosomal Scaffold",
      "components": [
        "CEP57",
        "CEP192",
        "AURKA",
        "PLK1"
      ],
      "role": "Organizes bipolar spindle pole nucleation, centrosome duplication, and spindle anchor integrity."
    },
    {
      "id": "Kinetochore_Motor",
      "name": "Outer Kinetochore & Corona",
      "components": [
        "CENPE",
        "CENPF",
        "MAD1L1",
        "BUB1"
      ],
      "role": "Mediates microtubule capture and tension sensing at the centromeric kinetochore."
    },
    {
      "id": "Disassembly_Regulator",
      "name": "Checkpoint Silencing AAA+ ATPase",
      "components": [
        "TRIP13",
        "p31comet (MAD2L1BP)"
      ],
      "role": "Catalyzes conversion of active closed-MAD2 to open-MAD2, enabling mitotic exit once chromosomes align."
    }
  ]
}