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data/pathway_network.json

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+{
+  "name": "Mitotic Spindle Assembly Checkpoint (SAC) & Centrosome Network",
+  "description": "Functional protein-protein interaction architecture governing chromosome segregation and spindle-kinetochore attachment.",
+  "complexes": [
+    {
+      "id": "MCC",
+      "name": "Mitotic Checkpoint Complex (MCC)",
+      "components": [
+        "BUBR1 (BUB1B)",
+        "BUB3",
+        "MAD2L1",
+        "CDC20"
+      ],
+      "role": "Inhibits Anaphase Promoting Complex/Cyclosome (APC/C) until all kinetochores are bioriented."
+    },
+    {
+      "id": "Centrosome",
+      "name": "Centriole & Centrosomal Scaffold",
+      "components": [
+        "CEP57",
+        "CEP192",
+        "AURKA",
+        "PLK1"
+      ],
+      "role": "Organizes bipolar spindle pole nucleation, centrosome duplication, and spindle anchor integrity."
+    },
+    {
+      "id": "Kinetochore_Motor",
+      "name": "Outer Kinetochore & Corona",
+      "components": [
+        "CENPE",
+        "CENPF",
+        "MAD1L1",
+        "BUB1"
+      ],
+      "role": "Mediates microtubule capture and tension sensing at the centromeric kinetochore."
+    },
+    {
+      "id": "Disassembly_Regulator",
+      "name": "Checkpoint Silencing AAA+ ATPase",
+      "components": [
+        "TRIP13",
+        "p31comet (MAD2L1BP)"
+      ],
+      "role": "Catalyzes conversion of active closed-MAD2 to open-MAD2, enabling mitotic exit once chromosomes align."
+    }
+  ]
+}