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README.md

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 # 🧬 MVA Syndrome Multi-Dimensional Genomic Studio
 
-A high-performance interactive research studio for exploring the **Rare Disease, Real Kid: MVA Hackathon 2026** dataset.
+A high-performance interactive research studio for exploring the **Rare Disease, Real Kid: MVA Hackathon 2026** dataset across 10 analytical dimensions.
 
-## Dimensions & High-Information-Density Modules
+## 📊 Analytical Dimensions & Deep Infotables
 1. **🏥 Clinical Phenotype & HPO Profile**: Proband clinical history, congenital nephrocalcinosis, rhabdomyosarcoma, severe IUGR, and parental recurrent pregnancy loss.
-2. **🧬 Whole-Genome Chromosome Ideogram & Variant Navigator**: 5.01M WGS variant density, 16 MVA/cancer candidate gene panels (*BUB1B*, *CEP57*, *TRIP13*, *CEP192*, *MAD1L1*, *BUB1*, *BUB3*, *SMC5*, *CENPE*, *CENPF*, *PLK1*, *AURKA*, *TP53*, *WT1*, *DICER1*).
-3. **🔬 Mosaic Somatic Allele Spectrum (VAF Analyzer)**: Identification and prioritization of post-zygotic mosaic mutations (VAF 5% – 38%).
-4. **📊 WGS Sequencing & Flowcell Profiler**: 4-lane Illumina NovaSeq sequencing statistics across 805M reads and 36.2× mean coverage.
-5. **⚙️ Mitotic Checkpoint Pathway**: Protein complexes governing chromosome segregation and spindle-kinetochore attachment.
-6. **⚡ 4D Mitotic Nondisjunction Simulation (7s)**: 60 FPS biophysical simulation of Spindle Assembly Checkpoint (SAC) failure, lagging chromosome entrapment, and micronucleus formation.
-7. **🌳 Clonal Variegation & Tissue Dynamics (8s)**: Embryonic clonal branching model from Zygote to organogenesis, showing mesodermal trapping in skeletal muscle (rhabdomyosarcoma niche) and metanephros (nephrocalcinosis).
-8. **⚛️ Kinetochore Nanomechanics (5s)**: Single-molecule nanomechanics showing CENPE kinesin 8.0 nm stepping, BUBR1 phosphorylation, and TRIP13 AAA+ hexameric ATPase remodeling.
+2. **🧬 Chromosome & Variant Navigator (5.01M WGS)**: Complete catalog of 5,012,204 whole-genome variant calls across 24 human chromosomes with reactive filters.
+3. **📋 Candidate Gene Burden & ACMG Matrix**: 16-gene matrix analyzing OMIM phenotypes, variant burdens, inheritance models, and diagnostic tiers (*BUB1B*, *CEP57*, *TRIP13*, *CEP192*, *MAD1L1*, *MAD2L1*, *BUB1*, *BUB3*, *SMC5*, *CENPE*, *CENPF*, *PLK1*, *AURKA*, *TP53*, *WT1*, *DICER1*).
+4. **🩺 Phenotype Constellation & Differential Matrix**: Cross-referencing observed clinical HPO findings against competing pediatric cancer and primordial growth syndromes.
+5. **⚡ Mosaic Allelic Stratification Table**: Stratification of variants by Variant Allele Frequency (VAF), developmental timing, and inferred tissue lineage penetrance.
+6. **🔬 Mitotic Machinery & Interactome Functional Table**: Biochemical, structural, and macromolecular properties of key mitotic checkpoint and centrosomal proteins.
+7. **🌐 24-Chromosome Karyotype & Instability Matrix**: Genome-wide breakdown of chromosomal physical lengths, variant densities, SNV/Indel ratios, and literature-reported MVA aneuploidy vulnerability rates.
+8. **🔬 Mosaicism & VAF Spectrum**: VAF distribution modeling and somatic mosaicism candidate isolation ($VAF \in [0.05, 0.38]$).
+9. **📊 WGS Sequencing & Flowcell Profiler**: 4-lane Illumina NovaSeq sequencing statistics across 805M reads and 36.2× mean coverage.
+10. **⚙️ Mitotic Checkpoint Pathway Network**: Molecular complex architecture for MCC, Centrosome, Kinetochore, and SAC silencing.