app.py

#!/usr/bin/env python3
# MedGenesis AI · CPU-only Streamlit app (OpenAI / Gemini)

import os, pathlib
import asyncio, re
from pathlib import Path

import streamlit as st
import pandas as pd
import plotly.express as px
from fpdf import FPDF
from streamlit_agraph import agraph

from mcp.orchestrator import orchestrate_search, answer_ai_question
from mcp.workspace import get_workspace, save_query
from mcp.knowledge_graph import build_agraph
from mcp.graph_metrics import build_nx, get_top_hubs, get_density
from mcp.alerts import check_alerts

# ── Streamlit telemetry dir fix ───────────────────────────────────────
os.environ["STREAMLIT_DATA_DIR"] = "/tmp/.streamlit"
os.environ["XDG_STATE_HOME"] = "/tmp"
os.environ["STREAMLIT_BROWSER_GATHERUSAGESTATS"] = "false"
pathlib.Path("/tmp/.streamlit").mkdir(parents=True, exist_ok=True)

ROOT = Path(__file__).parent
LOGO = ROOT / "assets" / "logo.png"

def _latin1_safe(txt: str) -> str:
    return txt.encode("latin-1", "replace").decode("latin-1")

def _pdf(papers):
    pdf = FPDF()
    pdf.set_auto_page_break(auto=True, margin=15)
    pdf.add_page()
    pdf.set_font("Helvetica", size=11)
    pdf.cell(200, 8, _latin1_safe("MedGenesis AI – Results"), ln=True, align="C")
    pdf.ln(3)
    for i, p in enumerate(papers, 1):
        pdf.set_font("Helvetica", "B", 11)
        pdf.multi_cell(0, 7, _latin1_safe(f"{i}. {p['title']}"))
        pdf.set_font("Helvetica", "", 9)
        body = f"{p['authors']}\n{p['summary']}\n{p['link']}\n"
        pdf.multi_cell(0, 6, _latin1_safe(body))
        pdf.ln(1)
    return pdf.output(dest="S").encode("latin-1", "replace")

def _workspace_sidebar():
    with st.sidebar:
        st.header("🗂️ Workspace")
        ws = get_workspace()
        if not ws:
            st.info("Run a search then press **Save** to populate this list.")
            return
        for i, item in enumerate(ws, 1):
            with st.expander(f"{i}. {item['query']}"):
                st.write(item["result"]["ai_summary"])

def render_ui():
    st.set_page_config("MedGenesis AI", layout="wide")

    # Initialize session state keys if missing
    if "query_result" not in st.session_state:
        st.session_state.query_result = None
    if "followup_input" not in st.session_state:
        st.session_state.followup_input = ""
    if "followup_response" not in st.session_state:
        st.session_state.followup_response = None
    if "last_query" not in st.session_state:
        st.session_state.last_query = ""
    if "last_llm" not in st.session_state:
        st.session_state.last_llm = ""

    _workspace_sidebar()

    c1, c2 = st.columns([0.15, 0.85])
    with c1:
        if LOGO.exists():
            st.image(str(LOGO), width=105)
    with c2:
        st.markdown("## 🧬 **MedGenesis AI**")
        st.caption("Multi-source biomedical assistant · OpenAI / Gemini")

    llm = st.radio("LLM engine", ["openai", "gemini"], horizontal=True)
    query = st.text_input("Enter biomedical question", placeholder="e.g. CRISPR glioblastoma therapy")

    # Alerts
    if get_workspace():
        try:
            news = asyncio.run(check_alerts([w["query"] for w in get_workspace()]))
            if news:
                with st.sidebar:
                    st.subheader("🔔 New papers")
                    for q, lnks in news.items():
                        st.write(f"**{q}** – {len(lnks)} new")
        except Exception:
            pass

    # Run search button
    if st.button("Run Search 🚀") and query:
        with st.spinner("Collecting literature & biomedical data …"):
            res = asyncio.run(orchestrate_search(query, llm=llm))
        st.success(f"Completed with **{res['llm_used'].title()}**")
        st.session_state.query_result = res
        st.session_state.last_query = query
        st.session_state.last_llm = llm
        st.session_state.followup_input = ""
        st.session_state.followup_response = None

    res = st.session_state.query_result

    if res:
        tabs = st.tabs(["Results", "Genes", "Trials", "Graph", "Metrics", "Visuals"])

        with tabs[0]:
            for i, p in enumerate(res["papers"], 1):
                st.markdown(f"**{i}. [{p['title']}]({p['link']})**  *{p['authors']}*")
                st.write(p["summary"])
            col1, col2 = st.columns(2)
            with col1:
                st.download_button("CSV", pd.DataFrame(res["papers"]).to_csv(index=False),
                                   "papers.csv", "text/csv")
            with col2:
                st.download_button("PDF", _pdf(res["papers"]), "papers.pdf", "application/pdf")
            if st.button("💾 Save"):
                save_query(st.session_state.last_query, res)
                st.success("Saved to workspace")

            st.subheader("UMLS concepts")
            for c in res["umls"]:
                if c.get("cui"):
                    st.write(f"- **{c['name']}** ({c['cui']})")

            st.subheader("OpenFDA safety")
            for d in res["drug_safety"]:
                st.json(d)

            st.subheader("AI summary")
            st.info(res["ai_summary"])

        with tabs[1]:
            st.header("Gene / Variant signals")
            for g in res["genes"]:
                st.write(f"- **{g.get('name', g.get('geneid'))}** {g.get('description','')}")
            if res["gene_disease"]:
                st.markdown("### DisGeNET links")
                st.json(res["gene_disease"][:15])
            if res["mesh_defs"]:
                st.markdown("### MeSH definitions")
                for d in res["mesh_defs"]:
                    if d:
                        st.write("-", d)

        with tabs[2]:
            st.header("Clinical trials")
            if not res["clinical_trials"]:
                st.info("No trials (rate-limited or none found).")
            for t in res["clinical_trials"]:
                st.markdown(f"**{t['NCTId'][0]}** – {t['BriefTitle'][0]}")
                st.write(f"Phase {t.get('Phase',[''])[0]} | Status {t['OverallStatus'][0]}")

        with tabs[3]:
            nodes, edges, cfg = build_agraph(res["papers"], res["umls"], res["drug_safety"])
            hl = st.text_input("Highlight node:", key="hl")
            if hl:
                pat = re.compile(re.escape(hl), re.I)
                for n in nodes:
                    n.color = "#f1c40f" if pat.search(n.label) else "#d3d3d3"
            agraph(nodes, edges, cfg)

        with tabs[4]:
            nodes, edges, _ = build_agraph(res["papers"], res["umls"], res["drug_safety"])
            G = build_nx([n.__dict__ for n in nodes], [e.__dict__ for e in edges])
            st.metric("Density", f"{get_density(G):.3f}")
            st.markdown("**Top hubs**")
            for nid, sc in get_top_hubs(G):
                lab = next((n.label for n in nodes if n.id == nid), nid)
                st.write(f"- {lab}  {sc:.3f}")

        with tabs[5]:
            years = [p["published"] for p in res["papers"] if p.get("published")]
            if years:
                st.plotly_chart(px.histogram(years, nbins=12, title="Publication Year"))

        # Follow-up Q&A block with callback
        st.markdown("---")
        st.text_input("Ask follow‑up question:", key="followup_input")
        def handle_followup():
            follow = st.session_state.followup_input
            if follow.strip():
                ans = asyncio.run(answer_ai_question(
                    follow,
                    context=st.session_state.last_query,
                    llm=st.session_state.last_llm))
                st.session_state.followup_response = ans["answer"]
            else:
                st.session_state.followup_response = None

        st.button("Ask AI", on_click=handle_followup)

        if st.session_state.followup_response:
            st.write(st.session_state.followup_response)

    else:
        st.info("Enter a question and press **Run Search 🚀**")

if __name__ == "__main__":
    render_ui()