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Verified signature# Human-Protein-Language-Model-0.5 ## Overview This repository contains 356 Pfam-level protein language model checkpoints generated for the study “Does domain-specific unsupervised fine-tuning improve protein language model performance?”. The checkpoints were derived from the ESM-2 650M model through unsupervised masked language modeling on sequences associated with human-proteome Pfam families. Protein sequences were clustered at a sequence-identity threshold of 0.5 before model fine-tuning. ## Repository organization Model checkpoints are organized by their corresponding Pfam identifiers. Each directory contains the checkpoint associated with that protein family or clan. ## Intended use These checkpoints are provided for research on protein representation learning, protein language model benchmarking, and the evaluation of domain-specific unsupervised fine-tuning. The models are intended for research use only and have not been validated for clinical or diagnostic applications…5a584c8
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